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https://www.readbyqxmd.com/read/29457968/in-vitro-and-in-vivo-effects-of-mk2206-and-chloroquine-combination-therapy-on-endometriosis-autophagy-may-be-required-for-regrowth-of-endometriosis
#1
Sachiko Matsuzaki, Jean-Luc Pouly, Michel Canis
BACKGROUND AND PURPOSE: A high recurrence rate after medical treatment is a major clinical problem for patients with endometriosis. In the present study, we evaluated the in vitro effects of combined treatment with MK2206 (an AKT inhibitor) + chloroquine on cell growth and regrowth of endometriotic stromal cells, and the in vivo effects on endometriotic implants in a mouse xenograft model of endometriosis. EXPERIMENTAL APPROACH: We evaluated the effects of autophagy inhibition by knockdown of the ATG13, Beclin-1, and ATG12 genes and pharmacologic agents (chloroquine, bafilomycin A1, or 3-methyalanine) individually and in combination with MK2206 on cell growth and/or cell regrowth of endometriotic stromal cells in vitro...
February 19, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29457934/early-placement-of-dental-implants-in-maxillary-sinus-grafted-with-leukocyte-and-platelet-rich-fibrin-l-prf-and-deproteinized-bovine-bone-mineral
#2
Elton Carlos Pichotano, Rafael Scaf de Molon, Luiz Guilherme Freitas de Paula, Ricardo Violante de Souza, Elcio Marcantonio, Daniela Leal Zandim-Barcelos
This case report aimed to describe the effects of leukocyte and platelet-rich fibrin (L-PRF) associated with deproteinized bovine bone mineral (DBBM) and absorbable collagen membrane (CM) on bone regeneration in maxillary sinus augmentation. A 59-year-old male patient was referred to the Department of Periodontology for implant rehabilitation of his edentulous upper jaw. The treatment plan involved maxillary sinus augmentation followed by implants installation. A split-mouth design was employed, in which the right maxillary sinus was filled using L-PRF, DBBM, and CM; the left side was filled with DBBM and CM...
February 19, 2018: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29457589/short-term-efficacy-of-pipeline-embolization-device-for-treating-complex-intracranial-aneurysms
#3
NiZaMiDingJiang ReXiaTi, ReXiDan AiKeReMu, KaHeErMan KaDeEr, Yan-Dong Fan, Zhao-Hai Feng, Kai Wang, TeWuErBaTi SuErTanNiYa, Tao-Tao Dou, Hai-Qiang Wu, MaiMaiTiLi AiSha, Xiao-Jiang Cheng
OBJECTIVE: To observe the short-term efficacy of Pipeline embolization divice (PED) for the treatment of complex intracranial aneurysms. METHODS: The clinical data of 29 consecutive patients with 32 intracranial aneurysms treated with PED between April 2015 to September 2016 were analyzed retrospectively. There were 3 small aneurysm, 15 large aneurysms, 8 giant aneurysms, 5 fusiform ayneurysms and 1 recidivation. The vessels include 25 anterior circulation and 4 posterior circulation...
2018: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/29457564/investigating-speech-recognition-and-listening-effort-with-different-device-configurations-in-adult-cochlear-implant-users
#4
Douglas P Sladen, Yingjiu Nie, Katelyn Berg
OBJECTIVES: The purpose of this study was to investigate speech recognition in noise and listening effort among a group of adults with cochlear implants (CIs). Two main research questions were addressed. First, what are the effects of omni versus directional microphone configuration on speech recognition and listening effort for noisy conditions? Second, what is the effect of unilateral versus bimodal or bilateral CI listening on speech recognition and listening effort in noisy conditions? DESIGN: Sixteen adults (mean age 58 years) with CIs participated...
May 2018: Cochlear Implants International
https://www.readbyqxmd.com/read/29457562/quality-of-life-outcomes-in-cochlear-implantation-of-children-with-profound-and-multiple-learning-disability
#5
Richard Benjamin Speaker, Jennifer Roberston, Cristina Simoes-Franklin, Fergal Glynn, Peter Walshe, Laura Viani
This study was performed to investigate the effect of cochlear implantation on the Quality of Life (QoL) of children with profound and multiple learning disability (PMLD). This cohort of children has been viewed historically as poor candidates for cochlear implantation as they generally have poor speech and hearing outcomes. The Irish National Cochlear Implant Program's prospectively maintained database was examined for all children implanted from July 1996 to July 2015. All charts of the 381 children implanted during this time were reviewed retrospectively; 16 children met criteria for being PMLD...
May 2018: Cochlear Implants International
https://www.readbyqxmd.com/read/29457288/injury-to-the-perineal-branch-of-the-pudendal-nerve-in-men-outcomes-from-surgical-resection-of-the-perineal-branches
#6
Eric L Wan, A Lee Dellon
OBJECTIVE: The objective is to report the outcome of an anterior surgical approach to treat neuroma of the perineal branch of the pudendal nerve (PBPN). PATIENTS AND METHODS: An IRB-approved prospective study enrolled 14 consecutive male patients from 2011 through 2015 who had symptoms of perineal/scrotal pain. Each patient had a successful, diagnostic, pudendal nerve block. The surgical procedure was resection of the PBPN and implantation of the nerve into the obturator internus muscle...
February 2018: Microsurgery
https://www.readbyqxmd.com/read/29456760/guided-growth-preliminary-results-of-a-multinational-study-of-967-physes-in-537-patients
#7
B Danino, R Rödl, J E Herzenberg, L Shabtai, F Grill, U Narayanan, E Segev, S Wientroub
Background: Guided growth by tension band plating is commonly used to correct coronal plane deformity. The purpose of this study was to measure the effect and further define parameters that influence results in coronal plane deformity around the knee. Methods: The retrospective multicentre study included data on 967 physes in 537 patients, with an average follow-up of 16 months after plate insertion. Alignment analysis was compared preoperatively and in at least two measurements postoperatively, as well as with parameters that influence the rate and amount of correction...
February 1, 2018: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29456704/optimal-method-of-gold-nanoparticle-administration-in-melanoma-bearing-mice
#8
Tetsuya Komatsu, Katsumasa Nakamura, Yasuhiro Okumura, Kenta Konishi
The present study assessed different methods of administering gold nanoparticles (GNPs) using different formulations to determine which of the methods achieved optimal radiosensitization. Cells from the B16F10 mouse melanoma cell line were implanted in the femoral area of mice, assigned to one of the eight following groups: i) Control; ii) intravenous (IV) injection of polyethylene glycol (PEG)-binding GNPs (Peg-GNPs) alone; iii) direct intratumoral (IT) injection of Peg-GNPs alone; iv) radiotherapy (RT)-alone; v) Peg-GNP IV + RT; vi) Peg-GNP IT + RT; vii) naked GNP (N-GNPs) IV + RT; and viii) N-GNP IT + RT...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456635/clinical-effect-of-platelet-rich-fibrin-on-the-preservation-of-the-alveolar-ridge-following-tooth-extraction
#9
Yingdi Zhang, Zheng Ruan, Minhua Shen, Luanjun Tan, Weiqin Huang, Lei Wang, Yuanliang Huang
The aim of the present study was to evaluate the clinical efficacy of platelet-rich fibrin (PRF) in preserving the alveolar ridge following human tooth extraction. A total of 28 patients were divided into two groups: The experimental and control groups (n=14 each). Following tooth extraction, the experimental group was implanted with PRF membrane, whereas the control group was not. The gingival healing effect was assessed at 7 days, 1 and 3 months later. Cone-beam computed tomography was performed immediately and at 3 months following tooth extraction...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456339/retrospective-analysis-of-arthrodesis-from-various-options-after-anterior-cervical-discectomy
#10
Vinaysagar Sharma, Shashwat Kumar Singh
Introduction: Anterior cervical discectomy is a surgical procedure performed to treat a herniated/degenerated disc in the cervical region. There have been various studies comparing arthrodesis rates among various procedures. Our patients belonged to varied socioeconomic background and underwent anterior cervical microdiscectomy without/with instrumentation. Aim: The present study was performed to study and compare the arthrodesis rates in the patients operated for anterior cervical microdiscectomy with and without fusion/instrumentation procedures at our institution...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29456260/rf-safety-evaluation-of-a-breast-tissue-expander-device-for-mri-numerical-simulation-and-experiment
#11
Bu S Park, Amir Razjouyan, Leonardo M Angelone, Brent McCright, Sunder S Rajan
This study describes the MRI-related radio frequency (RF) safety evaluation of breast tissue expander devices to establish safety criteria. Numerical simulations and experimental measurements were performed at 64 MHz with a gel phantom containing a breast expander. Additionally, computational modeling was performed (64 and 128 MHz) with an adult female model, containing a virtually implanted breast tissue expander device for four imaging landmark positions. The presence of the breast tissue expander device led to significant alterations in specific absorption rate (SAR) and|B1 + |distributions...
October 2017: IEEE Transactions on Electromagnetic Compatibility
https://www.readbyqxmd.com/read/29455763/low-major-adverse-cardiac-event-rates-following-bioresorbable-vascular-scaffold-implantation-impact-of-implantation-technique-on-treatment-outcomes
#12
Anne Venkata Ganeshkumar, Rushikesh Sambhaji Patil, Irfan Khan Hamid
BACKGROUND AND OBJECTIVE: Studies conducted across the world have reported that the rates of major adverse cardiac events (MACE) following the use of bioresorbable vascular scaffolds (BVS) are comparable to that noted with traditional drug eluting stents (DES). However, there is limited data on the immediate and medium-term clinical outcomes following the use of the Absorb BVS (Abbott Vascular, Santa Clara, SA) in the Indian context. This study was conducted to determine real-world evidence on the immediate and medium-term clinical outcomes in all patients undergoing percutaneous coronary intervention (PCI) with the Absorb BVS...
January 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29455621/optimization-of-endometrial-decidualization-in-the-menstruating-mouse-model-for-preclinical-endometriosis-research
#13
Daniëlle Peterse, Katrien De Clercq, Chloë Goossens, M Mercedes Binda, F O Dorien, Philippa Saunders, Joris Vriens, Amelie Fassbender, Thomas M D'Hooghe
BACKGROUND: To induce endometrial decidualization in rodents, an intrauterine oil stimulus can be delivered via the nontraumatic vagina or via the traumatic laparotomy. However, there is considerable variation in amount of decidualization using these inducing methods. Therefore, we studied which oil delivery route could achieve the highest rate of endometrial decidualization along the full length of both uterine horns. METHODS: To induce decidualization, ovariectomized C57Bl/6J mice were injected with estrogen (100 ng/day; 3 days)...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29455110/nipple-sparing-bilateral-prophylactic-mastectomy-and-immediate-reconstruction-with-tiloop-%C3%A2-bra-mesh-in-brca1-2-mutation-carriers-a-prospective-study-of-long-term-and-patient-reported-outcomes-using-the-breast-q
#14
D Casella, G Di Taranto, M Marcasciano, S Sordi, A Kothari, T Kovacs, F Lo Torto, E Cigna, D Ribuffo, C Calabrese
BACKGROUND: Although demand for prophylactic mastectomy is increasing over time among women at a high risk for breast cancer, there is a paucity of studies on long term patient-reported outcomes after this procedure. METHODS: Between January 2011 and January 2015, 46 patients documented BRCA1/2 mutation carriers, eligible for prophylactic nipple-sparing mastectomy (NSM) and immediate breast prosthetic reconstruction were registered at our institutions. Patients underwent NSM and subcutaneous reconstruction with implant covered by a titanium-coated polypropylene mesh (TiLoop® )...
February 15, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29455069/photo-crosslinkable-injectable-sericin-hydrogel-as-3d-biomimetic-extracellular-matrix-for-minimally-invasive-repairing-cartilage
#15
Chao Qi, Jia Liu, Yang Jin, Luming Xu, Guobin Wang, Zheng Wang, Lin Wang
Millions of patients worldwide suffer from cartilage injury and age/disease-related cartilage degeneration. However, cartilage, such as articular cartilage, is poor at self-regeneration. Current treatments are often invasive with limited efficacy. Developing minimal invasive strategies for effective cartilage repair is highly desired. Here, we report an injectable, photo-crosslinkable sericin hydrogel as a biomimetic extracellular matrix for minimal invasively repairing cartilage. Sericin was functionalized to be sericin methacryloyl (SerMA), which formed an in situ hydrogel upon UV light irradiation via photo-crosslinking...
February 9, 2018: Biomaterials
https://www.readbyqxmd.com/read/29455038/mechanical-and-degradation-property-improvement-in-a-biocompatible-mg-ca-sr-alloy-by-thermomechanical-processing
#16
Hunter B Henderson, Vidhya Ramaswamy, Alexander E Wilson-Heid, Michael S Kesler, Josephine B Allen, Michele V Manuel
Magnesium-based alloys have attracted interest as a potential material to comprise biomedical implants that are simultaneously high-strength and temporary, able to provide stabilization before degrading safely and able to be excreted by the human body. Many alloy systems have been evaluated, but this work reports on improved properties through hot extrusion of one promising alloy: Mg-1.0 wt% Ca-0.5 wt%Sr. This alloy has previously demonstrated promising toxicity and degradation properties in the as-cast and rolled conditions...
February 3, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29454973/comparison-of-dual-mobility-total-hip-arthroplasty-and-bipolar-arthroplasty-for-femoral-neck-fractures-a-retrospective-case-control-study-of-199-hips
#17
B Boukebous, P Boutroux, R Zahi, C Azmy, P Guillon
BACKGROUND: The choice between performing total hip arthroplasty (THA) or hemiarthroplasty (HA) is not straightforward in older patients with femoral neck fracture, particularly when co-morbidities are factored in. This led us to carry out a case-control study to determine 1) the rate of mechanical complications for these two types of implants, and 2) the rate of medical complications and mortality. HYPOTHESIS: THA with dual mobility cup (DM) will result in fewer mechanical complications than HA...
February 15, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29454531/orbital-atherectomy-for-the-treatment-of-small-2-5mm-severely-calcified-coronary-lesions-orbit-ii-sub-analysis
#18
Michael S Lee, Richard A Shlofmitz, Evan Shlofmitz, Pratyaksh K Srivastava, Jeremy Kong, Cindy Grines, George Revytak, Jeffrey W Chambers
OBJECTIVES: We assessed the safety and efficacy of orbital atherectomy to modify severely calcified coronary plaque prior to stent implantation in patients with small vessel (2.5mm) disease. BACKGROUND: Severe coronary artery calcification increases the risk of adverse clinical events during percutaneous coronary intervention (PCI). Patients who undergo PCI of small vessels have worse clinical outcomes including higher rates of perforation and dissection. The outcomes of orbital atherectomy of small diameter vessels (2...
October 3, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29454487/a-cost-utility-analysis-of-transcatheter-versus-surgical-aortic-valve-replacement-for-the-treatment-of-aortic-stenosis-in-the-population-with-intermediate-surgical-risk
#19
Derrick Y Tam, Avery Hughes, Stephen E Fremes, Saerom Youn, Rebecca L Hancock-Howard, Peter C Coyte, Harindra C Wijeysundera
OBJECTIVE: Although transcatheter aortic valve implantation has been shown to be noninferior to surgical aortic valve replacement in patients with severe aortic stenosis at intermediate surgical risk, the cost-effectiveness of this strategy in this population is unknown. Our objective was to conduct a cost-utility analysis comparing transcatheter aortic valve implantation with surgical aortic valve replacement in the population with intermediate risk severe aortic stenosis. METHODS: A fully probabilistic Markov model with 30-day cycles was constructed from the Canadian third-party payer's perspective to estimate the difference in cost and effectiveness (measured as quality-adjusted life years) of transcatheter aortic valve implantation versus surgical aortic valve replacement for intermediate-risk patients over a lifetime time horizon, discounted at 1...
February 2, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29454380/quality-of-life-satisfaction-and-outcomes-after-ministernotomy-versus-full-sternotomy-isolated-aortic-valve-replacement-quality-avr-study-protocol-for-a-randomised-controlled-trial
#20
Emiliano A Rodríguez-Caulo, Ana Guijarro-Contreras, Juan Otero-Forero, María José Mataró, Gemma Sánchez-Espín, Arantza Guzón, Carlos Porras, Miguel Such, Antonio Ordóñez, José María Melero-Tejedor, Manuel Jiménez-Navarro
BACKGROUND: During the last decade, the use of ministernotomy in cardiac surgery has increased. Quality of life and patient satisfaction after ministernotomy have never been compared to conventional full sternotomy in randomised trials. The aim of the study is to determine if this minimally invasive approach improves quality of life, satisfaction and clinical morbimortality outcomes. METHODS/DESIGN: The QUALITY-AVR trial is a single-blind, single-centre, independent, and pragmatic randomised clinical trial comparing ministernotomy ("J" shaped upper hemisternotomy toward right 4th intercostal space) to full sternotomy in patients with isolated severe aortic stenosis scheduled for elective aortic valve replacement...
February 17, 2018: Trials
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