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https://www.readbyqxmd.com/read/28595538/immune-cells-act-as-promising-targets-for-the-treatment-of-bone-metastasis
#1
Guojing Luo, Yuedong He, Qian Zhao, Xijie Yu
BACKGROUND: Bone metastasis is a common complication of certain types of cancer, and unfortunately, it is still incurable to date. Immune system is a major defence against tumor cells and bone metastasis. However, the immunodeficient mouse models are widely used in most researches of bone metastasis, thereby excluding the regulatory roles of the immune system in bone metastasis. OBJECTIVE: To provide a comprehensive overview on the cellular and molecular mechanisms by which immune cells interact with tumor cells and bone cells, as well as recent related patents...
June 6, 2017: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/28535661/-blastic-plasmacytoid-dentritic-cell-neoplasm-a-cases-report
#2
L H Dong, W J Wang, J L Chen, Y J Li, Y P Song, X D Wei, Y F Li
No abstract text is available yet for this article.
May 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28395455/-blastic-plasmacytoid-dentritic-cell-neoplasm-with-myeloproliferative-neoplasms-a-case-report
#3
J Han, Y Li, P J Wang, C L Shi, B Ding, L Wang
No abstract text is available yet for this article.
March 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28362548/immune-infiltration-of-tumor-microenvironment-following-immunotherapy-for-glioblastoma-multiforme
#4
Giannis Sokratous, Stavros Polyzoidis, Keyoumars Ashkan
BACKGROUND: Autologous dentritic cell immunotherapy has been proven effective in treating tumors outside the central nervous system. Current evidence from phase I and II trials suggest a similar efficacy for central nervous system tumors as well and that an active immune response against these tumors can be generated. OBJECTIVE: We aim to review the literature to identify the types of immune responses against gliomas found to be generated by dendritic cell vaccinations and the types of immune cells subsequently infiltrating the glioma microenvironment...
March 31, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27910914/in-vivo-stepwise-immunomodulation-using-chitosan-nanoparticles-as-a-platform-nanotechnology-for-cancer-immunotherapy
#5
Hee Dong Han, Yeongseon Byeon, Jong-Hwa Jang, Hat Nim Jeon, Ga Hee Kim, Min Gi Kim, Chan-Gi Pack, Tae Heung Kang, In Duk Jung, Yong Taik Lim, Young Joo Lee, Jeong-Won Lee, Byung Cheol Shin, Hyung Jun Ahn, Anil K Sood, Yeong-Min Park
Dentritic cell (DC)-based cancer immunotherapy faces challenges in both efficacy and practicality. However, DC-based vaccination requires multiple injections and elaborates ex vivo manipulation, which substantially limits their use. Therefore, we sought to develop a chitosan nanoparticle (CH-NP)-based platform for the next generation of vaccines to bypass the ex vivo manipulation and induce immune responses via active delivery of polyinosinic-polycytidylic acid sodium salt (poly I:C) to target Toll-like receptor 3 (TLR3) in endosomes...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27865391/modulation-of-dendritic-cell-and-monocyte-subsets-in-tuberculosis-diabetes-co-morbidity-upon-standard-tuberculosis-treatment
#6
Nathella Pavan Kumar, Kadar Moideen, Shanmugam Sivakumar, Pradeep A Menon, Vijay Viswanathan, Hardy Kornfeld, Subash Babu
Type 2 diabetes mellitus (DM) is a major risk factor for the development of active pulmonary tuberculosis (PTB), with development of DM pandemic in countries where tuberculosis (TB) is also endemic. However, the effect of anti-TB treatment on the changes in dentritic cell (DC) and monocyte subset phenotype in TB-DM co-morbidity is not well understood. In this study, we characterized the frequency of DC and monocyte subsets in individuals with PTB with (PTB-DM) or without coincident diabetes mellitus (PTB-NDM) before, during and after completion of anti-TB treatment...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27713136/the-role-of-extracellular-vesicles-in-mediating-progression-metastasis-and-potential-treatment-of-hepatocellular-carcinoma
#7
REVIEW
Naibin Yang, Shanshan Li, Guoxiang Li, Shengguo Zhang, Xinyue Tang, Shunlan Ni, Xiaomin Jian, Cunlai Xu, Jiayin Zhu, Mingqin Lu
Hepatocellular carcinoma (HCC) is a major cause of cancer-related death worldwide. As vectors for intercellular information exchange, the potential role of extracellular vesicles (EVs) in HCC formation, progression and therapy has been widely investigated. In this review, we explore the current status of the researches in this field. Altogether there is undeniable evidence that EVs play a crucial role in HCC development, metastasis. Moreover, EVs have shown great potential as drug delivery systems (DDSs) for the treatment of HCC...
January 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/27401056/metastasis-suppressor-1-regulates-neurite-outgrowth-in-primary-neuron-cultures
#8
Juan Yu, Shuyun Lin, Mei Wang, Lijun Liang, Zijiao Zou, Xinfeng Zhou, Meichi Wang, Ping Chen, Ying Wang
Metastasis suppressor 1 (MTSS1) or missing in metastasis (MIM) is an actin- and membrane-binding protein with tumor suppressor functions. MTSS1 is important for cell morphology, motility, metastasis. The role of MTSS1 in cell morphology has been widely investigated in non-neuronal tissues; however the role of MTSS1 in neurite outgrowth remains unclear. Here we investigated the effect of MTSS1 on neurite outgrowth in primary cerebellar granule and hippocampal neurons of mouse. We found that overexpression of MTSS1 in cerebellar granule neurons significantly enhanced dendrite elaboration but inhibited axon elongation...
October 1, 2016: Neuroscience
https://www.readbyqxmd.com/read/27125983/human-plasmacytoid-dentritic-cells-elicit-a-type-i-interferon-response-by-sensing-dna-via-the-cgas-sting-signaling-pathway
#9
Christian Bode, Mario Fox, Poonam Tewary, Almut Steinhagen, Richard K Ellerkmann, Dennis Klinman, Georg Baumgarten, Veit Hornung, Folkert Steinhagen
Plasmacytoid dendritic cells (pDCs) are a major source of type I interferon (IFN) and are important for host defense by sensing microbial DNA via TLR9. pDCs also play a critical role in the pathogenesis of IFN-driven autoimmune diseases. Yet, this autoimmune reaction is caused by the recognition of self-DNA and has been linked to TLR9-independent pathways. Increasing evidence suggests that the cytosolic DNA receptor cyclic GMP-AMP (cGAMP) synthase (cGAS) is a critical component in the detection of pathogens and contributes to autoimmune diseases...
July 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27121009/rod-shaped-and-fluorine-substituted-hydroxyapatite-free-of-molecular-immunopotentiators-stimulates-anti-cancer-immunity-in-vivo
#10
Xiupeng Wang, Xia Li, Atsuo Ito, Yohei Watanabe, Noriko M Tsuji
Herein, rod-shaped and fluorine-substituted hydroxyapatite nanoparticles (FHA) were synthesized using a facile hydrothermal method. The rod-shaped FHA significantly increased the cellular uptake of a model antigen by bone marrow dentritic cells in vitro, improved antigen presentation in vivo, stimulated immune-related cytokine secretion in vitro and ex vivo, and enhanced the anti-cancer immunity in vivo.
June 4, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/26818188/crispr-cas9-mediated-efficient-pd-1-disruption-on-human-primary-t-cells-from-cancer-patients
#11
Shu Su, Bian Hu, Jie Shao, Bin Shen, Juan Du, Yinan Du, Jiankui Zhou, Lixia Yu, Lianru Zhang, Fangjun Chen, Huizi Sha, Lei Cheng, Fanyan Meng, Zhengyun Zou, Xingxu Huang, Baorui Liu
Strategies that enhance the function of T cells are critical for immunotherapy. One negative regulator of T-cell activity is ligand PD-L1, which is expressed on dentritic cells (DCs) or some tumor cells, and functions through binding of programmed death-1 (PD-1) receptor on activated T cells. Here we described for the first time a non-viral mediated approach to reprogram primary human T cells by disruption of PD-1. We showed that the gene knockout of PD-1 by electroporation of plasmids encoding sgRNA and Cas9 was technically feasible...
January 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26796363/characterisation-and-functional-implications-of-the-two-new-hla-g-alleles-found-in-amerindian-and-caribbean-populations
#12
Antonio Arnaiz-Villena, Mercedes Enriquez-de-Salamanca, Jose Palacio-Grüber, Cristina Campos, Alejandro Camacho, Jose Manuel Martin-Villa, Narcisa Martinez-Quiles, Eduardo Gomez-Casado, Ester Muñiz
HLA-G polymorphism has been found to be relatively low in all world populations. In the present paper two new HLA-G molecules are described in ancient American natives. A new HLA-G molecule from a Ecuador Amerindian individual (male) showed four codon changes with respect to HLA-G*01:01:01. Silent changes at α1 domain (residue 57, Pro, CCG→CCA) and α2 domain (residue 93, His, CAC→CAT and residue 100, Gly, GGC→GGT) and one productive change in α3 domain (residue 219 changed from Arg to Trp). This α3 change may dramatically alter HLA-G interactions with beta-2 microglobulin, CD8, ILT-2 and ILT-4 ligands present in subsets of T, B, NK, monocytes, macrophages and dentritic cells...
September 2016: Human Immunology
https://www.readbyqxmd.com/read/26734458/a2b-adenosine-receptor-activation-switches-differentiation-of-bone-marrow-cells-to-a-cd11c-gr-1-dendritic-cell-subset-that-promotes-the-th17-response
#13
Dongchun Liang, Aijun Zuo, Hui Shao, Mingjiazi Chen, Henry J Kaplan, Deming Sun
Adenosine is one of the major molecules associated with inflammation. We have previously reported that an adenosine receptor (AR) agonist has an enhancing effect on Th17 autoimmune responses, even though it suppressed Th1 responses. To determine the mechanism involved, we have examined the effect of AR agonists on mouse bone marrow dendritic cell (BMDC) differentiation and function. We show that mouse bone marrow cells (BMCs) differentiated into CD11c(+)Gr-1(+) dentritic cells (DCs) when cultured in granulocyte macrophage colony-stimulating factor (GM-CSF)-containing medium containing an AR agonist...
December 2015: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/26700228/rod-shaped-and-substituted-hydroxyapatite-nanoparticles-stimulating-type-1-and-2-cytokine-secretion
#14
Xiupeng Wang, Xia Li, Atsuo Ito, Yohei Watanabe, Yu Sogo, Motohiro Hirose, Tadao Ohno, Noriko M Tsuji
A Th1 immune response is required for modern vaccines as the most commonly used alum adjuvant has weak capacity for inducing Th1 immune response. Herein, rod-shaped hydroxyapatite (HA), magnesium-substituted HA (MgHA) and zinc-substituted HA (ZnHA) nanoparticles with irregular nanopores were synthesized and used as immunoadjuvants. Magnesium and zinc substitution in HA showed no influence on morphology, particle size, zeta potential and surface area of the nanoparticles. The rod-shaped MgHA and ZnHA nanoparticles promoted the cellular uptake of a molecular immunopotentiator, stimulated both type 1 and 2 cytokine secretion in vitro that relate to Th1 and Th2 immunity of bone marrow dentritic cells, respectively...
March 1, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/26647852/synthetic-innate-defense-regulator-peptide-combination-using-cpg-odn-as-a-novel-adjuvant-induces-long%C3%A2-lasting-and-balanced-immune-responses
#15
Chao-Heng Yu, Zi-Chao Luo, Meng Li, Lian Lu, Zhan Li, Xiao-Zhe Wu, Ying-Zi Fan, Hai-Long Zhang, Bai-Ling Zhou, Yang Wan, Ke Men, Yao-Mei Tian, Shuang Chen, Feng-Jiao Yuan, Rong Xiang, Li Yang
Vaccines are critical tools for the prevention and treatment of several diseases. Adjuvants have been traditionally used to enhance immunity to vaccines and experimental antigens. In the present study, the adjuvant combination of CpG oligodeoxynucleotides (CpG ODN) and the innate defense regulator (IDR) peptide, IDR‑HH2, was evaluated for its ability to enhance and modulate the immune response when formulated with alum and the recombinant hepatitis B surface antigen (HBsAg). The CpG‑HH2 complex enhanced the secretions of tumor necrosis factor‑α, monocyte chemotactic protein 1 and interferon‑γ by human peripheral blood mononuclear cells and promoted murine bone marrow dentritic cell maturation...
January 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/26472466/improving-immunological-tumor-microenvironment-using-electro-hyperthermia-followed-by-dendritic-cell-immunotherapy
#16
Yuk-Wah Tsang, Cheng-Chung Huang, Kai-Lin Yang, Mau-Shin Chi, Hsin-Chien Chiang, Yu-Shan Wang, Gabor Andocs, Andras Szasz, Wen-Tyng Li, Kwan-Hwa Chi
BACKGROUND: The treatment of intratumoral dentritic cells (DCs) commonly fails because it cannot evoke immunity in a poor tumor microenvironment (TME). Modulated electro-hyperthermia (mEHT, trade-name: oncothermia) represents a significant technological advancement in the hyperthermia field, allowing the autofocusing of electromagnetic power on a cell membrane to generate massive apoptosis. This approach turns local immunogenic cancer cell death (apoptosis) into a systemic anti-tumor immune response and may be implemented by treatment with intratumoral DCs...
2015: BMC Cancer
https://www.readbyqxmd.com/read/26363053/phosphatase-pp4-negatively-regulates-type-i-ifn-production-and-antiviral-innate-immunity-by-dephosphorylating-and-deactivating-tbk1
#17
Zhenzhen Zhan, Hao Cao, Xuefeng Xie, Linshan Yang, Peng Zhang, Yihan Chen, Huimin Fan, Zhongmin Liu, Xingguang Liu
The effective recognition of viral infection and subsequent type I IFN production is essential for the host antiviral innate immune responses. The phosphorylation and activation of kinase TANK-binding kinase 1 (TBK1) plays crucial roles in the production of type I IFN mediated by TLR and retinoic acid-inducible gene I-like receptors. Type I IFN expression must be tightly regulated to prevent the development of immunopathological disorders. However, how the activated TBK1 is negatively regulated by phosphatases remains poorly understood...
October 15, 2015: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/26321956/adrenergic-regulation-of-innate-immunity-a-review
#18
REVIEW
Angela Scanzano, Marco Cosentino
The sympathetic nervous system has a major role in the brain-immune cross-talk, but few information exist on the sympathoadrenergic regulation of innate immune system. The aim of this review is to summarize available knowledge regarding the sympathetic modulation of the innate immune response, providing a rational background for the possible repurposing of adrenergic drugs as immunomodulating agents. The cells of immune system express adrenoceptors (AR), which represent the target for noradrenaline and adrenaline...
2015: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/26320318/-role-of-dentritic-epidermal-t-lymphocytes-in-immune-rejection-of-skin-allograft-in-mice-and-its-mechanism
#19
Hua Huang, Rongshuai Yan, Meisi Liu, Junyi Zhou, Jianglin Tan, Xiaorong Zhang, Xiao-hong Hu, Yong Huang, Weifeng He, Jun Wu, Gaoxing Luo
To explore the role of dentritic epidermal T lymphocytes ( DETCs) in immune rejection of skin allograft in mice and its related mechanism. Methods (1) Full-thickness skin was harvested from back of one male wild type (WT) C57BL/6 mouse. Epithelial cells were isolated for detection of the expression of DETCs and their phenotype with flow cytometer. Another male WT C57BL/6 mouse was used to harvest full-thickness skin from the back. Epidermis was isolated for observation of the morphological characteristics of DETCs with immunofluorescence technology...
April 2015: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/26214786/differential-roles-of-porphyromonas-gingivalis-lipopolysaccharide-and-escherichia-coli-lipopolysaccharide-in-maturation-and-antigen-presenting-functions-of-dentritic-cells
#20
H Su, X Yan, Z Dong, W Chen, Z-T Lin, Q-G Hu
OBJECTIVE: The aim of this research is to study the roles of Porphyromonas gingivalis-lipopolysaccharide (P. gingivalis-LPS) and Escherichia coli-lipopolysaccharide (E. coli-LPS) on maturation and antigen-presenting functions of dendritic cells (DCs), and to provide experimental evidences to explore the possible mechanism of DCs in periodontitis. MATERIALS AND METHODS: Flow cytometry was used to detect CD11c, MHC-II, CD80, CD86 and CD40 expression on DCs which were stimulated by P...
July 2015: European Review for Medical and Pharmacological Sciences
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