Sonia Melgar-Locatelli, M Carmen Mañas-Padilla, Ana L Gavito, Patricia Rivera, Celia Rodríguez-Pérez, Estela Castilla-Ortega, Adriana Castro-Zavala
Sex differences in declarative memory are described in humans, revealing a female or a male advantage depending on the task. Specifically, spatial memory (i.e., spatial navigation) is typically most efficient in men. This sexual dimorphism has been replicated in male rats but not clearly in mice. In this study, sex differences in spatial memory were assessed in thirty-six C57BL/6J mice (Janvier Labs; i.e., C57BL/6JRj mice), a widely used mouse substrain. Both male and female mice (12 weeks-old) were subjected to standard behavioral paradigms: the elevated plus maze, the open field test, the novel object and place tests, the forced swimming test, and the water maze test for spatial navigation...
December 10, 2023: Behavioural Brain Research