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https://www.readbyqxmd.com/read/28428033/a-critical-analysis-of-limb-symmetry-indices-of-hop-tests-in-athletes-after-anterior-cruciate-ligament-reconstruction-a-case-control-study
#1
Alli Gokeler, Wouter Welling, Anne Benjaminse, Koen Lemmink, Romain Seil, Stefano Zaffagnini
BACKGROUND: Hop tests are frequently used to determine return to sports (RTS) after anterior cruciate ligament reconstruction (ACLR). Given that bilateral deficits are present after ACLR, this may result in a falsely high limb symmetry index (LSI), since LSI is calculated as a ratio between the values of the limbs. HYPOTHESIS: Athletes after ACLR would achieve LSI > 90% for the hop test. Secondly, athletes after ACLR demonstrate decreased jump distance on the single hop for distance (SLH) and triple leg hop for distance (TLH) and decreased number of hops for the side hop (SH) for both involved and uninvolved limbs compared to normative data of sex, age and type of sports matched healthy athletes...
April 17, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28370430/reversible-folding-of-a-%C3%AE-hairpin-peptide-containing-a-metal-chelating-amino-acid
#2
Jan Reutzel, Timm Marian Diogo, Armin Geyer
5-(1-Hydroxy-pyridin-2(1H)-onyl) L-alanine (Hop) is a N-hydroxy-1,2-pyridone functionalized α-amino acid with the desired metal chelating properties of DOPA but without its unwanted redox activity. The Fmoc-protected amino acid Fmoc-L-Hop(tBu)-OH (11) was synthesized from glycine phosphonate followed by enzymatic hydrolysis of the methyl ester yielding the Hop L-isomer in 96% ee. The amino acid 11 is used in automated peptide synthesis for the assembly of a 14mer β-hairpin peptide with the sequence [dsb1,14]H-CHXETGKHGHKLVC-OH (X = W, L-Hop)...
April 3, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28361285/evaluation-of-lower-limb-kinetics-during-gait-sprint-and-hop-tests-before-and-after-anterior-cruciate-ligament-reconstruction
#3
Joaquín Moya-Angeler, Javier Vaquero, Francisco Forriol
BACKGROUND: The purpose of this study was to evaluate the functional status prior to and at different times after anterior cruciate ligament reconstruction (ACLR), and to analyze the changes in the kinetic patterns of the involved and uninvolved lower limb during gait, sprint and three hop tests. MATERIALS AND METHODS: Seventy-four male patients with an ACL injury were included in the study. All patients performed a standardized kinetic protocol including gait, sprint and three hop tests (single-leg hop, drop vertical jump and vertical jump tests), preoperatively and at 3, 6, and 12 months after ACLR with a semitendinosus gracilis tendon autograft...
March 30, 2017: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/28301433/a-comparison-of-bilateral-muscular-imbalance-ratio-calculations-using-functional-tests
#4
Theodoros M Bampouras, Susan Dewhurst
Bilateral muscular imbalance can increase the risk of injury and negatively impact sporting performance. Bilateral muscular imbalances are typically calculated as ((side 1-side 2)/reference value) x 100, to provide a percentage value of the difference between limbs. Using different numerator (right-left or strong-weak) or reference values (left, right, strong, weak, average of the two) could mask or inflate the true difference value. The present study aimed to compare the bilateral muscular imbalance ratio calculations, using the absolute difference between limbs as the numerator and the five different options as reference values...
March 13, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28270021/tropomyosin-receptor-kinase-inhibitors-an-updated-patent-review-for-2010-2016-part-ii
#5
Justin J Bailey, Ralf Schirrmacher, Kristen Farrell, Vadim Bernard-Gauthier
TrkA/B/C receptor activation supports growth, survival, and differentiation of discrete neuronal populations during development, adult life, and ageing but also plays numerous roles in human disease onset and progression. Trk-specific inhibitors have therapeutic applications in cancer and pain and thus constitute a growing area of interest in oncology and neurology. There has been substantial growth in the number of structural classes of Trk inhibitors and the number of industrial entrants to the Trk inhibitor field over the past six years...
March 8, 2017: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/28245409/-abnormal-notch-hes-signaling-pathways-and-acute-leukemia-review
#6
Zhen-Yang Gu, Li Wang, Chun-Ji Gao
The abnormal activation of Notch signaling is closely related to the development of acute leukemia (AL). The core elements of the Notch signaling system include Notch receptors, Notch ligands, CSL DNA-binding proteins, and effectors like target genes. Any factors, which affect ligands, receptors, signal transducers and effectors, can influence the signal transduction of Notch signaling greatly. Based on the role of Notch signaling in AL, several targeted drugs against Notch upstream signaling have been developed...
February 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28192831/training-effects-of-the-fifa-11-and-harmoknee-on-several-neuromuscular-parameters-of-physical-performance-measures
#7
RANDOMIZED CONTROLLED TRIAL
Francisco Ayala, Carlos Pomares-Noguera, Francisco Javier Robles-Palazón, Maria Del Pilar García-Vaquero, Ignacio Ruiz-Pérez, Sergio Hernández-Sánchez, Mark De Ste Croix
The main purpose of this study was to analyse the training effects of the FIFA 11+ and Harmoknee on several parameters of physical performance measures in youth amateur football players. 41 adolescent players were randomised within each team into 2 groups (team 1: control vs. FIFA 11+; team 2: control vs. Harmoknee). The FIFA 11+ and Harmoknee groups performed the program 3 times a week for 4 weeks; the control groups completed their usual warm-up routines. 13 physical performance measures (joint range of motion, dynamic postural control, single legged hop limb symmetry, sprint time, jumping height and agility) were assessed...
April 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28186834/elevated-knee-joint-kinetics-and-reduced-ankle-kinetics-are-present-during-jogging-and-hopping-after-achilles-tendon-ruptures
#8
Richard W Willy, Annelie Brorsson, Hayley C Powell, John D Willson, Roy Tranberg, Karin Grävare Silbernagel
BACKGROUND: Deficits in plantarflexor function are common after an Achilles tendon rupture. These deficits may result in an altered distribution of joint loads during lower extremity tasks. HYPOTHESIS: We hypothesized that, regardless of treatment, the Achilles tendon-ruptured limb would exhibit deficits in ankle kinematics and joint power while exhibiting elevated knee joint power and patellofemoral joint loads during walking, jogging, and hopping. We further hypothesized that this loading pattern would be most evident during jogging and hopping...
April 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28146394/functional-performance-among-active-female-soccer-players-after-unilateral-primary-anterior-cruciate-ligament-reconstruction-compared-with-knee-healthy-controls
#9
Anne Fältström, Martin Hägglund, Joanna Kvist
BACKGROUND: Good functional performance with limb symmetry is believed to be important to minimize the risk of injury after a return to pivoting and contact sports after anterior cruciate ligament reconstruction (ACLR). PURPOSE: This study aimed to investigate any side-to-side limb differences in functional performance and movement asymmetries in female soccer players with a primary unilateral anterior cruciate ligament (ACL)-reconstructed knee and to compare these players with knee-healthy controls from the same soccer teams...
February 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28054115/-risk-and-benefit-of-nutritional-supplements-for-the-treatment-of-postmenopausal-complaints
#10
Patrick Diel, Anne Kurrat, Christina Oden, Lars Hanke
Menopause is for many females associated with an occurrence of a variety of health complaints and a decrease in quality in life. Hot flashes, sleep disturbances and a variety of other symptoms result in a strong psychological strain. Hormone replacement therapy for treatment of climacteric complaints is discussed controversially regarding associated side effects. This is a major reason to propose treatment with plant derived extracts and compounds as an alternative. Such compounds are available either as drugs but mostly as nutritional supplements...
January 4, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28045144/adsorbate-interactions-on-the-gan-0001-surface-and-their-effect-on-diffusion-barriers-and-growth-morphology
#11
Manjusha Chugh, Madhav Ranganathan
Studying the adsorbate interactions on a surface helps in understanding the growing surface morphologies and calculating the effective surface diffusion barriers. We study the interaction between Ga-Ga, N-N and Ga-N adatom pairs on the polar GaN(0001) surface using ab initio calculations based on density functional theory. The interaction energy between two adatoms on the surface does not seem to follow definite trends with increasing distance between the adatoms. The presence of a number of possible reconstructions on clean GaN(0001) and periodic effects due to the finite size complicate the analysis of the interactions...
January 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28038341/standing-balance-and-inter-limb-balance-asymmetry-at-one-year-post-primary-anterior-cruciate-ligament-reconstruction-sex-differences-in-a-cohort-study-of-414-patients
#12
Ross A Clark, Stuart W Bell, Julian A Feller, Timothy S Whitehead, Kate E Webster
BACKGROUND: Static standing balance can be safely assessed early following anterior cruciate ligament reconstruction (ACLR), and deficits may have important implications for long-term outcomes. This study includes a large cohort of people post-ACLR and has the primary aim of establishing whether inter-limb and sex differences exist, with a secondary aim of assessing the association between static balance variables and other outcome measures. METHODS: A total of 414 patients with a primary ACLR performed a 30-s static single leg balance test...
February 2017: Gait & Posture
https://www.readbyqxmd.com/read/28036030/xanthohumol-a-prenylated-chalcone-from-hops-inhibits-the-viability-and-stemness-of-doxorubicin-resistant-mcf-7-adr-cells
#13
Ming Liu, Hua Yin, Xiaokun Qian, Jianjun Dong, Zhonghua Qian, Jinlai Miao
Xanthohumol is a unique prenylated flavonoid in hops (Humulus lupulus L.) and beer. Xanthohumol has been shown to possess a variety of pharmacological activities. There is little research on its effect on doxorubicin-resistant breast cancer cells (MCF-7/ADR) and the cancer stem-like cells exiting in this cell line. In the present study, we investigate the effect of xanthohumol on the viability and stemness of MCF-7/ADR cells. Xanthohumol inhibits viability, induces apoptosis, and arrests the cell cycle of MCF-7/ADR cells in a dose-dependent manner; in addition, xanthohumol sensitizes the inhibition effect of doxorubicin on MCF-7/ADR cells...
December 28, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27998667/validity-and-reliability-of-a-novel-instrumented-one-legged-hop-test-in-patients-with-knee-injuries
#14
Karin Mani, William F Brechue, Bernd Friesenbichler, Nicola A Maffiuletti
BACKGROUND: Conventional one-legged hop tests simply evaluate the total hop distance, thus neglecting important temporal and spatial parameters related to the strategy of execution, such as foot contact time. AIM: To examine the validity and reliability of an instrumented one-legged hop test, the "four hops, three contacts" (4H3C) test, in patients with knee injuries. METHODS: The 4H3C test consists of four consecutive one-legged hops, of which individual hop distance and foot contact time are recorded by a validated floor-based photocell system...
December 17, 2016: Knee
https://www.readbyqxmd.com/read/27904796/functional-hop-tests-and-tuck-jump-assessment-scores-between-female-division-i-collegiate-athletes-participating-in-high-versus-low-acl-injury-prone-sports-a-cross-sectional-analysis
#15
Philipp Hoog, Meghan Warren, Craig A Smith, Nicole J Chimera
BACKGROUND: Although functional tests including the single leg hop (SLH), triple hop (TH), cross over hop (COH) for distance, and the tuck jump assessment (TJA) are used for return to play (RTP) criteria for post anterior cruciate ligament (ACL) injury, sport-specific baseline measurements are limited. PURPOSE: The purpose of this study was to examine differences in SLH, TH, and COH distance and limb symmetry index (LSI), as well as total scores, number of jumps, and individual flaws of the TJA in 97 injury-free Division I (DI) collegiate female student athletes participating in ACL injury prone vs...
December 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27893474/hypertrophy-and-explosive-reactive-functioning-in-sedentary-men-following-10-weeks-of-whole-body-vibration
#16
Jens Ebing, Ulf Gast, Christoph Hauptmann, Dieter Felsenberg, Daniel L Belavý
The objective of this study was to determine the impact of vertical (Power-plate; POW) and side-alternating (Galileo; GAL) whole-body vibration exercise on muscle mass and lower-limb neuromuscular function. Forty-three sedentary male subjects (18-30yr) randomized into three groups underwent two upper-body exercise sessions per week for 10 weeks. Two groups of subjects underwent additional squat exercises on the GAL (N=15) or POW (N=14) devices. The third group was control. On magnetic resonance imaging, volume of the thigh muscles was measured...
November 16, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27869529/low-fundamental-movement-skill-proficiency-is-associated-with-high-bmi-and-body-fatness-in-girls-but-not-boys-aged-6-11-years-old
#17
Michael J Duncan, Elizabeth Bryant, David Stodden
This study examined differences in children's body mass index (BMI) and body fatness (BF%) as a function of gender and fundamental movement skill (FMS) proficiency. Following ethics approval and parental consent, 248, 6-11 year-old children (112 boys, 136 girls) underwent assessment of 7 FMS: sprint run, side gallop, hop, kick, catch, throw and vertical jump. FMS tertiles ("high", "medium" or "low" FMS) were created based on the summed components of the FMS. Skinfold measures were used to calculate BF%. Physical activity (PA) was assessed using pedometry and maturation predicted using anthropometry...
November 21, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27837221/femoral-avulsion-fracture-of-acl-proximal-attachment-in-male-scuba-diver-case-report-and-review-of-the-literature
#18
Sebastian Zabierek, Krzysztof Nowak, Marcin Domzalski
Femoral ACL avulsion fractures were not well described in the literature, and there were only several reports describing mostly immature patients. A case of 50-year-old man with ACL femoral attachment avulsion fracture after pivoting knee injury during skiing was presented. The bony attachment was reduced and fixed arthroscopically with screws. Four months after surgery, patient was allowed to return to full sport activity with full range of motion. He was able to perform a one-leg-hop test without limitation, and the strength of quadriceps muscle was comparable to contralateral side...
November 11, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27834590/clinical-effects-of-dry-needling-among-asymptomatic-individuals-with-hamstring-tightness-a-randomized-controlled-trial
#19
Kathleen Geist, Claire Bradley, Alan Hofman, Rob Koester, Fenella Roche, Annalise Shields, Elizabeth Frierson, Ainsley Rossi, Marie Johanson
STUDY DESIGN: Randomized controlled trial. OBJECTIVES: The aim of this study was to determine the effects of dry needling on hamstring extensibility and functional performance tests among asymptomatic individuals with hamstring muscle tightness. BACKGROUND: Dry needling has been shown to increase range of motion in the upper quarter and may have similar effects in the lower quarter. METHODS: Twenty-seven subjects with hamstring extensibility deficits were randomly assigned to side of treatment (dominant or non-dominant) and group (blunt needling or dry needling)...
November 11, 2016: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/27821609/structure-and-mechanism-of-the-atp-synthase-membrane-motor-inferred-from-quantitative-integrative-modeling
#20
Vanessa Leone, José D Faraldo-Gómez
Two subunits within the transmembrane domain of the ATP synthase-the c-ring and subunit a-energize the production of 90% of cellular ATP by transducing an electrochemical gradient of H(+) or Na(+) into rotational motion. The nature of this turbine-like energy conversion mechanism has been elusive for decades, owing to the lack of definitive structural information on subunit a or its c-ring interface. In a recent breakthrough, several structures of this complex were resolved by cryo-electron microscopy (cryo-EM), but the modest resolution of the data has led to divergent interpretations...
December 2016: Journal of General Physiology
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