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Neelaveni Thangavel, Mohammad Al Bratty, Sadique Akhtar Javed, Waquar Ahsan, Hassan Al Hazmi
Design of novel PPAR-γ modulators with better binding efficiency and fewer side effects to treat type 2 diabetes is still a challenge for medicinal chemists. Cost and time efficient computational methods have presently become an integral part of research in nuclear receptors and their ligands, enabling hit to lead identification and lead optimization. This review will focus on cutting-edge technologies used in most recent studies on the design of PPAR- γ agonists and will discuss the chemistry of a few molecules which emerged successful...
February 27, 2018: Current Drug Discovery Technologies
Erlantz Fernández de Gorostiza, Jorge Berzosa, Jon Mabe, Roberto Cortiñas
Industrial wireless applications often share the communication channel with other wireless technologies and communication protocols. This coexistence produces interferences and transmission errors which require appropriate mechanisms to manage retransmissions. Nevertheless, these mechanisms increase the network latency and overhead due to the retransmissions. Thus, the loss of data packets and the measures to handle them produce an undesirable drop in the QoS and hinder the overall robustness and energy efficiency of the network...
February 23, 2018: Sensors
Uta Wille, Joses Nathanael, Luke Gamon, Meike Cordes, Paul Rablen, Thomas Bally, Katharina Fromm, Bernd Giese
Nature uses proteins as medium for long-distance electron transfer (ET) to carry out redox reactions in distant compartments. This ET occurs either by a single-step superexchange or through a multi-step charge hopping process, which uses side chains of amino acids as stepping stones. In this study we demonstrate that Phe can act as a relay amino acid for long-distance electron hole transfer through peptides. The considerably increased susceptibility of the aromatic ring to oxidation is caused by the lone pairs of neighbouring amide carbonyl groups, which stabilize the Phe radical cation...
February 19, 2018: Chembiochem: a European Journal of Chemical Biology
Divya Srinivasan, Eva Tengman, Charlotte K Häger
BACKGROUND: Recent studies highlight the need for understanding movement control of adjacent joints when evaluating knee function following anterior cruciate ligament (ACL) injury. However, while short-term adaptations to lower-extremity joint coupling have been studied, little is known about any potential long-term adaptations in neuromuscular control displayed by ACL-injured individuals. The aim of our study was to determine whether coordination variability of the hip-knee joint couplings during the one-leg hop is altered about 20 years after injury in two ACL-injured groups compared to healthy knee controls...
February 6, 2018: Clinical Biomechanics
J Chris Coetzee, J Kent Ellington, James A Ronan, Rebecca M Stone
BACKGROUND: The Broström procedure is the most commonly used lateral ligament repair for chronic instability, but there is concern about the strength of the repair and the risk of reinjury. Currently, the InternalBraceTM ligament augmentation repair is an accepted augmentation method for management of a Broström procedure. Our hypothesis was that augmentation of the Broström repair with an InternalBraceTM would allow accelerated rehabilitation and return to activity and would aid in stability of the repair without a tendency to stretch...
February 1, 2018: Foot & Ankle International
Eric Hamrin Senorski, Eleonor Svantesson, Susanne Beischer, Christoffer Thomeé, Alberto Grassi, Ferid Krupic, Roland Thomeé, Jón Karlsson, Kristian Samuelsson
PURPOSE: A better understanding of patient characteristics and the way common concomitant injuries affect the recovery of muscle function after surgery should help providers to treat patients with anterior cruciate ligament (ACL) injuries. The aim of this study was to determine whether patient characteristics, concomitant injuries and graft choice at ACL reconstruction were associated with symmetrical knee muscle function at one year. The hypothesis was that the presence of concomitant injuries would negatively influence the opportunity to achieve symmetrical knee function at the one-year follow-up...
February 5, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Daniel R Kohn, Przemyslaw Gawel, Yaoyao Xiong, Kirsten E Christensen, Harry L Anderson
Extended triisopropylsilyl end-capped polyynes have been prepared from the corresponding tetracobalt complexes by removing the complexed dicobalt tetracarbonyldiphenylphosphinomethane (Co2(CO)4dppm) moieties. Unmasking of this 'masked alkyne equivalent' was achieved under mild conditions with elemental iodine at room temperature, making it possible to obtain fragile polyynes with up to 20 contiguous sp-hybridized carbon atoms. The Co2(CO)4dppm moiety has a strong geometric and steric effect on the polyyne, but does not have a marked electronic effect on the terminal alkyne, as indicated by NMR and IR spectroscopy, density functional theory calculations and X-ray crystallography...
January 23, 2018: Journal of Organic Chemistry
Mikko Vihtakari, Jorg Welcker, Børge Moe, Olivier Chastel, Sabrina Tartu, Haakon Hop, Claus Bech, Sébastien Descamps, Geir Wing Gabrielsen
Climate warming is rapidly altering marine ecosystems towards a more temperate state on the European side of the Arctic. However, this "Atlantification" has rarely been confirmed, as long-term datasets on Arctic marine organisms are scarce. We present a 19-year time series (1982-2016) of diet samples from black-legged kittiwakes as an indicator of the changes in a high Arctic marine ecosystem (Kongsfjorden, Svalbard). Our results highlight a shift from Arctic prey dominance until 2006 to a more mixed diet with high contribution of Atlantic fishes...
January 19, 2018: Scientific Reports
Thiago Jambo Alves Lopes, Milena Simic, Daniel de Souza Alves, Priscila Dos Santos Bunn, Allan Inoue Rodrigues, Bruno de Souza Terra, Maicom da Silva Lima, Fabrício Miranda Ribeiro, Patrick Vilão, Evangelos Pappas
The objectives were to provide normative data on commonly used physical performance tests that may be associated with musculoskeletal injuries in Navy cadets, and assess for sex and limb dominance differences. A large cohort of Navy cadets were assessed for physical performance tests of flexibility (ankle dorsiflexion range of motion and sit and reach), isometric hip strength, lower limb power (single leg hop), and trunk endurance (plank and side plank tests). Besides providing normative data tables, sex and limb dominance differences were assessed by a two-way mixed ANOVA...
January 17, 2018: Journal of Strength and Conditioning Research
M Hopping, A F Merry, J J Pandit
We conducted an online survey to assess the career experiences of wrong side blocks, the practice of Stop-Before-You-Block, the recently described method of Mock-Before-You-Block and attitudes to these. Respondents were 208 anaesthetists across nine hospitals (173 consultants or Staff and Associate Specialist doctors'), representing 3623 years of collective anaesthetic practice. There had been a total of 62 wrong side blocks (by 51 anaesthetists and one current trainee). Predisposing factors for this were commonly ascribed to distractions (35 (69%), for example due to rushing or teaching), patient positioning (9 (18%)) or miscommunication (6 (12%))...
December 27, 2017: Anaesthesia
Adam B Rosen, Alan R Needle, Jupil Ko
OBJECTIVE: The purpose of this systematic review with meta-analysis was to determine the effectiveness of functional performance tests (FPTs) in differentiating between individuals with chronic ankle instability (CAI) and healthy controls. DATA SOURCES: The National Library of Medicine Catalog (PubMed), the Cumulative Index for Nursing and Allied Health Literature (CINAHL), and the SPORTDiscus, from inception to June 2017 were searched. Search terms consisted of: "Functional Performance Test*" OR "Dynamic Balance Test*" OR "Postural Stability Test*" OR "Star Excursion Balance Test*" OR "Hop Test*" AND "Ankle Instability" OR "Ankle Sprain...
December 22, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
Zhengbang Wang, Cong Liang, Haolin Tang, Sylvain Grosjean, Artak Shahnas, Joerg Lahann, Stefan Bräse, Christof Wöll
Achieving high values for proton conductivity in a material critically depends on providing hopping sites arranged in a regular fashion. Record values reported for regular, molecular crystals cannot yet be reached by technologically relevant systems, and the best values measured for polymer membranes suited for integration into devices are almost two orders of magnitude lower. Here, an alternative polymer membrane synthesis strategy based on the chemical modification of surface-mounted, monolithic, crystalline metal-organic framework thin films is demonstrated...
December 18, 2017: Macromolecular Rapid Communications
Ainsley Rossi, Sara Blaustein, Joshua Brown, Kari Dieffenderfer, Elaine Ervin, Steven Griffin, Elizabeth Frierson, Kathleen Geist, Marie Johanson
Background: In addition to established interventions, dry needling may reduce impairments leading to greater functional abilities for individuals following ankle sprain. Hypothesis/Purpose: The purpose of this study was to compare effects of spinal and peripheral dry needling (DN) with peripheral DN alone on impairments and functional performance among individuals with a history of lateral ankle sprain. Study Design: Randomized controlled trial...
December 2017: International Journal of Sports Physical Therapy
S Chaudhuri, P A Bhobe, A K Nigam
The investigation of the magnetotransport properties on [Formula: see text] [Formula: see text]Sbx with 0 [Formula: see text] 0.6 are presented in this paper. The substitution of Sb in place of Sn decreases the anti-site disorder as evident from x-ray diffraction patterns as well as from transport properties measurement. The much-disputed upturn in low temperature electrical resistivity of [Formula: see text]TiSn has been demonstrated to be a result of weak localization induced by anti-site disorder. With increased Sb substitution (⩾25%) the metallic transport behavior of [Formula: see text]TiSn changes to semiconductor-like...
December 6, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Braidy C Shambaugh, Joshua R Olsen, Edward Lacerte, Ethan Kellum, Suzanne L Miller
Background: The early repair of acute proximal hamstring ruptures provides better clinical results than delayed repair. However, it is unclear how nonoperative treatment compares with the operative treatment of these injuries. Purpose: To compare the clinical results of the nonoperative and operative treatment of acute proximal hamstring ruptures. Study Design: Cohort study; Level of evidence, 3. Methods: A total of 25 patients with complete, retracted proximal hamstring ruptures presenting to 1 institution were retrospectively reviewed...
November 2017: Orthopaedic Journal of Sports Medicine
Karen Savage, Joseph Firth, Con Stough, Jerome Sarris
Anxiety disorders are chronic and functionally disabling conditions with high psychological stress, characterised by cognitive symptoms of excessive worry and focus difficulties and physiological symptoms such as muscle tension and insomnia. Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter within the central nervous system and is a key target of pharmacotherapies in the treatment of anxiety. Although current pharmaceutical treatments are often efficacious, they may cause undesirable side effects including cognitive decrements and withdrawal symptoms...
November 23, 2017: Phytotherapy Research: PTR
Sayan Chaudhuri, P A Bhobe, Arun Kumar Nigam
Investigation of magnetotransport properties on Fe<sub>2</sub>TiSn<sub>1-x</sub>Sb<sub>x</sub> with 0 ≤ x ≤ 0.6 are presented in this paper. The substitution of Sb in place of Sn decreases the antisite disorder as evident from X ray diffraction patterns as well as from transport properties measurement. The much-disputed upturn in low temperature electrical resistivity of Fe<sub>2</sub>TiSn has been demonstrated to be a result of weak localization induced by antisite disorder...
November 21, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Ravi Gupta, Munish Sood, Anubhav Malhotra, Gladson David Masih, Anil Kapoor, Mukta Raghav, Mehar Dhillon
PURPOSE: To compare the results of bone-patellar tendon-bone graft (BPTB), semitendinosus-gracilis graft with preserved insertions (STGPI) and semitendinosus-gracilis-free graft (STGF) in terms of graft failure, objective mechanical stability, functional outcome, and return to sports in elite and recreational sports persons. It was hypothesized that the STGPI graft provided superior outcome as compared to the other two grafts. METHODS: Two hundred and forty-nine elite and recreational players who underwent ACL reconstruction surgery, with BPTB graft (N = 80), STGPI graft (N = 85), and STGF graft (N = 84) with a minimum follow-up of 2 years, were assessed using clinical tests, knee arthrometer (KT 1000™), single-leg hop test, Lysholm knee score, Tegner's activity scale, and return to sports...
November 14, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Wen-Qing Jia, Zhi Jing, Xin Liu, Xiao-Yan Feng, Ya-Ya Liu, Shu-Qing Wang, Wei-Ren Xu, Jian-Wen Liu, Xian-Chao Cheng
The thiazolidinedione class PPARγ agonists as antidiabetic agents are restricted in clinical use because of the side effects such as edema, weight gain, and heart failure. The single and selective agonism of PPARγ is the main cause of side effects. The multi-target cooperative PPARα/γ dual agonist development is a hot topic in the antidiabetic medicinal chemistry field. Saroglitazar is the first approved PPARα/γ dual agonist, available in India for the treatment of diabetic dyslipidemia. It got rid of these side effects...
October 28, 2017: Journal of Biomolecular Structure & Dynamics
Annelie Brorsson, Karin Grävare Silbernagel, Nicklas Olsson, Katarina Nilsson Helander
BACKGROUND: Optimizing calf muscle performance seems to play an important role in minimizing impairments and symptoms after an Achilles tendon rupture (ATR). The literature lacks long-term follow-up studies after ATR that describe calf muscle performance over time. PURPOSE: The primary aim was to evaluate calf muscle performance and patient-reported outcomes at a mean of 7 years after ATR in patients included in a prospective, randomized controlled trial. A secondary aim was to evaluate whether improvement in calf muscle performance continued after the 2-year follow-up...
February 2018: American Journal of Sports Medicine
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