Shivendra Singh, Jie Fang, Hongjian Jin, Lee-Ann Van de Velde, Qiong Wu, Andrew Cortes, Christopher L Morton, Mary A Woolard, Waise Quarni, Jacob A Steele, Jon P Connelly, Liusheng He, Rebecca Thorne, Gregory Turner, Thomas Confer, Melissa Johnson, William V Caufield, Burgess B Freeman, Timothy Lockey, Shondra M Pruett-Miller, Ruoning Wang, Andrew M Davidoff, Paul G Thomas, Jun Yang
The cellular plasticity of neuroblastoma is defined by a mixture of two major cell states, adrenergic (ADRN) and mesenchymal (MES), which may contribute to therapy resistance. However, how neuroblastoma cells switch cellular states during therapy remains largely unknown and how to eradicate neuroblastoma regardless of their cell states is a clinical challenge. To better understand the lineage switch of neuroblastoma in chemoresistance, we comprehensively defined the transcriptomic and epigenetic map of ADRN and MES types of neuroblastomas using human and murine models treated with indisulam, a selective RBM39 degrader...
March 25, 2024: bioRxiv