Erin L Glynn, Lucy W Piner, Kim M Huffman, Cris A Slentz, Lorraine Elliot-Penry, Hiba AbouAssi, Phillip J White, James R Bain, Michael J Muehlbauer, Olga R Ilkayeva, Robert D Stevens, Kathryn N Porter Starr, Connie W Bales, Elena Volpi, M Julia Brosnan, Jeff K Trimmer, Timothy P Rolph, Christopher B Newgard, William E Kraus
AIMS/HYPOTHESES: Obesity is associated with decreased insulin sensitivity (IS) and elevated plasma branched-chain amino acids (BCAAs). The purpose of this study was to investigate the relationship between BCAA metabolism and IS in overweight (OW) individuals during exercise intervention. METHODS: Whole-body leucine turnover, IS by hyperinsulinaemic-euglycaemic clamp, and circulating and skeletal muscle amino acids, branched-chain α-keto acids and acylcarnitines were measured in ten healthy controls (Control) and nine OW, untrained, insulin-resistant individuals (OW-Untrained)...
October 2015: Diabetologia