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https://www.readbyqxmd.com/read/29169189/lifelong-voluntary-exercise-modulates-age-related-changes-in-oxidative-stress
#1
Mohamed Amine Bouzid, Edith Filaire, Régis Matran, Sophie Robin, Claudine Fabre
The hypothesis that aging and regular physical activity could influence oxidative stress has been studied by comparing antioxidant activities (superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione reductase (GR), ascorbic acid and α-Tocopherol) and malondialdehyde level (MDA) in four groups: young sedentary (n=15; age: 20.3±2.8 years; YS), young active (n=16; age: 21.4±1.9 years; YA), old sedentary (n=15; age: 65.1±3.5 years; OS) and old active (n=17; age: 67.2±4.8 years; OA). Antioxidant activities and MDA level were assessed at rest and after an incremental exercise...
November 23, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29169152/knockdown-of-caveolin-1-sensitizes-human-basal-like-triple-negative-breast-cancer-cells-to-radiation
#2
Man Zou, Yanhui Li, Shu Xia, Qian Chu, Xiaoguang Xiao, Hong Qiu, Yu Chen, Zu'an Zheng, Fei Liu, Liang Zhuang, Shiying Yu
BACKGROUND/AIMS: Triple-negative breast cancer (TNBC) is a high-risk breast cancer phenotype without specific targeted therapy options and is significantly associated with increased local recurrence in patients treated with radiotherapy. CAVEOLIN-1 (CAV-1)-mediated epidermal growth factor receptor (EGFR) nuclear translocation following irradiation promotes DNA repair and thus induces radiation resistance. In this study, we aimed to determine whether knockdown of CAV-1 enhances the radiosensitivity of basal-like TNBC cell lines and to explore the possible mechanisms...
November 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29169122/ptsd-with-and-without-dissociation-in-young-children-exposed-to-interpersonal-trauma
#3
Melissa J Hagan, Miya Gentry, Chandra Ghosh Ippen, Alicia F Lieberman
BACKGROUND: A Dissociative Subtype of Posttraumatic Stress Disorder (PTSD) was added to the DSM-5, but little is known about this symptom pattern in young children exposed to trauma. Tailoring treatment to traumatized young children requires understanding the different patterns of trauma-related symptomatology and important correlates. The current study tested the hypothesis that type and number of child traumatic events, caregiver trauma exposure, and caregiver symptomatology would predict whether traumatized young children presented with PTSD, PTSD with clinical dissociation, or non-clinical trauma symptoms...
November 14, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29169103/impact-of-roadway-geometric-features-on-crash-severity-on-rural-two-lane-highways
#4
Nima Haghighi, Xiaoyue Cathy Liu, Guohui Zhang, Richard J Porter
This study examines the impact of a wide range of roadway geometric features on the severity outcomes of crashes occurred on rural two-lane highways. We argue that crash data have a hierarchical structure which needs to be addressed in modeling procedure. Moreover, most of previous studies ignored the impact of geometric features on crash types when developing crash severity models. We hypothesis that geometric features are more likely to determine crash type, and crash type together with other occupant, environmental and vehicle characteristics determine crash severity outcome...
November 20, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29169032/altering-movement-parameters-disrupts-metacognitive-accuracy
#5
E R Palser, A Fotopoulou, J M Kilner
Correctly estimating the confidence we should have in our decisions has traditionally been viewed as a perceptual judgement based solely on the strength or quality of sensory information. However, accumulating evidence has demonstrated that the motor system contributes to judgements of perceptual confidence. Here, we manipulated the speed at which participants' moved using a behavioural priming task and showed that increasing movement speed above participants' baseline measures disrupts their ability to form accurate confidence judgements about their performance...
November 20, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/29169013/body-mass-index-and-risk-of-dementia-analysis-of-individual-level-data-from-1-3-million-individuals
#6
Mika Kivimäki, Ritva Luukkonen, G David Batty, Jane E Ferrie, Jaana Pentti, Solja T Nyberg, Martin J Shipley, Lars Alfredsson, Eleonor I Fransson, Marcel Goldberg, Anders Knutsson, Markku Koskenvuo, Eeva Kuosma, Maria Nordin, Sakari B Suominen, Töres Theorell, Eero Vuoksimaa, Peter Westerholm, Hugo Westerlund, Maria Zins, Miia Kivipelto, Jussi Vahtera, Jaakko Kaprio, Archana Singh-Manoux, Markus Jokela
INTRODUCTION: Higher midlife body mass index (BMI) is suggested to increase the risk of dementia, but weight loss during the preclinical dementia phase may mask such effects. METHODS: We examined this hypothesis in 1,349,857 dementia-free participants from 39 cohort studies. BMI was assessed at baseline. Dementia was ascertained at follow-up using linkage to electronic health records (N = 6894). We assumed BMI is little affected by preclinical dementia when assessed decades before dementia onset and much affected when assessed nearer diagnosis...
November 20, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29168895/epigenetics-as-a-driver-of-developmental-origins-of-health-and-disease-did-we-forget-the-fathers
#7
REVIEW
Adelheid Soubry
What are the effects of our environment on human development and the next generation? Numerous studies have provided ample evidence that a healthy environment and lifestyle of the mother is important for her offspring. Biological mechanisms underlying these environmental influences have been proposed to involve alterations in the epigenome. Is there enough evidence to suggest a similar contribution from the part of the father? Animal models provide proof of a transgenerational epigenetic effect through the paternal germ line, but can this be translated to humans? To date, literature on fathers is scarce...
November 23, 2017: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/29168890/toward-improved-analysis-of-concentration-data-embracing-nondetects
#8
REVIEW
Niloofar Shoari, Jean-Sébastien Dubé
Various statistical tests on concentration data serve to support decision-making regarding characterization and monitoring of contaminated media, assessing exposure to a chemical, and quantifying the associated risks. However, the routine statistical protocols cannot be directly applied because of challenges arising from nondetects or left-censored observations that are concentration measurements below detection limit of measuring instruments. Despite the existence of techniques based on survival analysis that can adjust for nondetects, these are seldom taken into account properly...
November 23, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29168787/fred-exergame-to-prevent-dependence-and-functional-deterioration-associated-with-ageing-a-pilot-three-week-randomized-controlled-clinical-trial
#9
Iranzu Mugueta-Aguinaga, Begonya Garcia-Zapirain
Introduction: Frailty syndrome and advanced age may decrease the acceptance of illness and quality of life, and worsen patients' existing health conditions, as well as leading to an increase in health care expenses. Purpose: The purpose of this study is to reduce frailty risk via the use of a FRED game which has been expressly designed and put together for the study. Materials and methods: A total of 40 frail volunteers with a score of <10 points in the short physical performance battery (SPPB) took part in a feasibility study in order to validate the FRED game...
November 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29168593/respiratory-regulation-by-steroids-in-newborn-rats-a-sex-specific-balance-between-allopregnanolone-and-progesterone-receptors
#10
Vincent Joseph, NagaPraveena Uppari, Hayet Kouchi, Celia De Bruyn, Ryma Boukari, Aida Bairam
We tested the hypothesis that the effects of progesterone on apnoea frequency in newborn rats are the result of a balance between its neuroactive metabolite allopregnanolone (GABAa receptor modulator) and progesterone receptors. We used male and female rats between 10 and 12 days of age and recorded respiratory and metabolic parameters (whole-body plethysmography), and assessed the frequency and duration of apnoeas under normoxia. We tested the effects of a single injection of progesterone (4 mg kg(-1) , i...
November 23, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/29168401/the-clinical-benefit-of-hyperthermia-in-pancreatic-cancer-a-systematic-review
#11
Astrid van der Horst, Eva Versteijne, Marc G H Besselink, Joost G Daams, Esther B Bulle, Maarten F Bijlsma, Johanna W Wilmink, Otto M van Delden, Jeanin E van Hooft, Nicolaas A P Franken, Hanneke W M van Laarhoven, Johannes Crezee, Geertjan van Tienhoven
OBJECTIVE: In pancreatic cancer, which is therapy resistant due to its hypoxic microenvironment, hyperthermia may enhance the effect of radio(chemo)therapy. The aim of this systematic review is to investigate the validity of the hypothesis that hyperthermia added to radiotherapy and/or chemotherapy improves treatment outcome for pancreatic cancer patients. METHODS AND MATERIALS: We searched MEDLINE and Embase, supplemented by handsearching, for clinical studies involving hyperthermia in pancreatic cancer patients...
November 23, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29168286/comparative-proteomic-profiling-reveals-a-role-for-cisd2-in-skeletal-muscle-aging
#12
Yi-Long Huang, Zhao-Qing Shen, Chia-Yu Wu, Yuan-Chi Teng, Chen-Chung Liao, Cheng-Heng Kao, Liang-Kung Chen, Chao-Hsiung Lin, Ting-Fen Tsai
Skeletal muscle has emerged as one of the most important tissues involved in regulating systemic metabolism. The gastrocnemius is a powerful skeletal muscle composed of predominantly glycolytic fast-twitch fibers that are preferentially lost among old age. This decrease in gastrocnemius muscle mass is remarkable during aging; however, the underlying molecular mechanism is not fully understood. Strikingly, there is a ~70% decrease in Cisd2 protein, a key regulator of lifespan in mice and the disease gene for Wolfram syndrome 2 in humans, within the gastrocnemius after middle age among mice...
November 23, 2017: Aging Cell
https://www.readbyqxmd.com/read/29168281/a-review-of-urban-impacts-on-avian-life-history-evolution-does-city-living-lead-to-slower-pace-of-life
#13
REVIEW
Tuul Sepp, Kevin J McGraw, Ants Kaasik, Mathieu Giraudeau
The concept of a pace-of-life syndrome describes inter- and intraspecific variation in several life-history traits along a slow-to-fast pace-of-life continuum, with long lifespans, low reproductive and metabolic rates, and elevated somatic defences at the slow end of the continuum and the opposite traits at the fast end. Pace-of-life can vary in relation to local environmental conditions (e.g. latitude, altitude), and here we propose that this variation may also occur along an anthropogenically modified environmental gradient...
November 23, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29168200/the-moderating-role-of-job-resources-in-the-relationship-between-job-demands-and-interleukin-6-in-an-italian-healthcare-organization
#14
Alessandra Falco, Laura Dal Corso, Damiano Girardi, Alessandro De Carlo, Manola Comar
In this study we examined the association between job demands (JD), job resources (JR), and serum levels of a possible biomarker of stress, the pro-inflammatory cytokine interleukin-6 (IL-6). According to the buffer hypothesis of the Job Demands-Resources (JD-R) model, we expected that job resources-defined as job autonomy and social support from supervisor-might buffer the relationship between job demands, defined as emotional demands and interpersonal conflict with colleagues, and IL-6. Data from 119 employees in an Italian public healthcare organization (acute care hospital) were analyzed using multiple regression...
November 23, 2017: Research in Nursing & Health
https://www.readbyqxmd.com/read/29168172/extracellular-adenosine-induced-rac1-activation-in-pulmonary-endothelium-molecular-mechanisms-and-barrier-protective-role
#15
Anita Kovacs-Kasa, Kyung Mi Kim, Mary Cherian-Shaw, Stephen M Black, David J Fulton, Alexander D Verin
We have previously shown that Gs-coupled adenosine receptors (A2a) are primarily involved in adenosine-induced human pulmonary artery endothelial cell (HPAEC) barrier enhancement. However, the downstream events that mediate the strengthening of the endothelial cell (EC) barrier via adenosine signaling are largely unknown. In the current study we tested the overall hypothesis that adenosine-induced Rac1 activation and EC barrier enhancement is mediated by Gs-dependent stimulation of cAMP-dependent Epac1-mediated signaling cascades...
November 23, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29168126/do-alerting-signals-increase-the-size-of-the-attentional-focus
#16
Verena C Seibold
Previous research has shown that the presentation of an auditory alerting signal before a visual target increases the interference from flanking distractors. Recently, it has been suggested that this increase in interference may be due to an expansion of the spatial focus of attention. In five experiments, this hypothesis was tested by using a probe technique dedicated to measuring variations in the size of the attentional focus: In the majority of trials, participants performed a letter discrimination task in which their attention was focused on a central target letter...
November 22, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/29167982/successional-changes-in-trophic-interactions-support-a-mechanistic-model-of-post-fire-population-dynamics
#17
Annabel L Smith
Models based on functional traits have limited power in predicting how animal populations respond to disturbance because they do not capture the range of demographic and biological factors that drive population dynamics, including variation in trophic interactions. I tested the hypothesis that successional changes in vegetation structure, which affected invertebrate abundance, would influence growth rates and body condition in the early-successional, insectivorous gecko Nephrurus stellatus. I captured geckos at 17 woodland sites spanning a succession gradient from 2 to 48 years post-fire...
November 22, 2017: Oecologia
https://www.readbyqxmd.com/read/29167874/hair-repigmentation-with-anti-pd-1-and-anti-pd-l1-immunotherapy-a-novel-hypothesis
#18
Deshan Frank Sebaratnam, Ana Isabel Rodríguez Bandera, Patricia Margaret Lowe
No abstract text is available yet for this article.
November 22, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29167872/hair-repigmentation-with-anti-pd-1-and-anti-pd-l1-immunotherapy-a-novel-hypothesis-reply
#19
Noelia Rivera, Aram Boada, Carlos Ferrándiz
No abstract text is available yet for this article.
November 22, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29167871/hair-repigmentation-with-anti-pd-1-and-anti-pd-l1-immunotherapy-a-novel-hypothesis
#20
Guillaume Manson, Aurélien Marabelle, Roch Houot
No abstract text is available yet for this article.
November 22, 2017: JAMA Dermatology
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