keyword
MENU ▼
Read by QxMD icon Read
search

vascular cognitive impairment

keyword
https://www.readbyqxmd.com/read/29332036/relationships-between-lower-olfaction-and-brain-white-matter-lesions-in-elderly-subjects-with-mild-cognitive-impairment
#1
Juliette Heinrich, Jean-Sébastien Vidal, Axelle Simon, Anne-Sophie Rigaud, Olivier Hanon, Jacques Epelbaum, Cecile Viollet, Emmanuelle Duron
BACKGROUND: Olfactory impairment is reported in mild cognitive impairment (MCI) and Alzheimer's disease (AD) and is associated with hippocampal atrophy. In elderly people, dementia with AD neuropathology and white matter lesions (WML) is common. In this context, olfactory impairment could also depend on the presence of WML. OBJECTIVE: To assess the cross-sectional relationship between olfaction and WML in elderly subjects with MCI. METHODS: Consecutive subjects, >65 years old, diagnosed as MCI after a comprehensive neuropsychological assessment in an expert memory center, with a brain MRI performed within a year and without major depressive state, were included...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29328980/consequence-of-intraventricular-hemorrhage-on-neurovascular-coupling-evoked-by-speech-syllables-in-preterm-neonates
#2
Mahdi Mahmoudzadeh, Ghislaine Dehaene-Lambertz, Guy Kongolo, Marc Fournier, Sabrina Goudjil, Fabrice Wallois
Intraventricular Hemorrhage (IVH) is the leading cause of neurological and cognitive impairment in preterm neonates with an incidence that increases with increasing prematurity. In the present study, we tested how preterm neonates with IVH react to external stimulation (i.e. speech syllables). We compared their neural responses measured by electroencephalography (EEG), and hemodynamic responses measured by functional near-infrared spectroscopy (fNIRS), with those of healthy preterms. A neural response to syllables was observed in these infants, but did not induce a vascular response in contrast with healthy neonates...
January 5, 2018: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29326289/prevalence-of-hippocampal-enlarged-perivascular-spaces-in-a-sample-of-patients-with-hypertension-and-their-relation-with-vascular-risk-factors-and-cognitive-function
#3
Joan Jiménez-Balado, Iolanda Riba-Llena, Edurne Garde, Marta Valor, Belen Gutiérrez, Francesc Pujadas, Pilar Delgado
OBJECTIVES: The clinical importance of hippocampal enlarged perivascular spaces (H-EPVS) remains uncertain. We aimed to study their association with vascular risk factors, cognitive function and mild cognitive impairment (MCI). METHODS: Data were obtained from the ISSYS (Investigating Silent Strokes in hYpertensives, a magnetic resonance imaging Study) cohort, which is a prospective study of patients with hypertension aged 50-70 with no prior stroke or dementia...
January 11, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29322980/neurology-of-renal-disorders
#4
Pushpendra N Renjen, Dinesh Chaudhari, Gaurav Sagar, Sanjiv Jasuja
Chronic kidney disease (CKD) is a critical and rapidly growing global health problem. Neurological complications occur in almost all patients with severe CKD, potentially affecting all levels of the nervous system, from the central nervous system (CNS) through to the peripheral nervous system (PNS). Patients with CKD exhibit a high incidence of symptomatic and occult cerebrovascular diseases, associated tremendously high levels of inflammatory factors and homocysteine, as well as anemia, hypertension, and diabetes...
January 2018: Neurology India
https://www.readbyqxmd.com/read/29320772/a-perfect-storm-the-role-of-the-mammalian-target-of-rapamycin-mtor-in-cerebrovascular-dysfunction-of-alzheimer-s-disease-a-mini-review
#5
Candice E Van Skike, Veronica Galvan
Cerebrovascular dysfunction is detected prior to the onset of cognitive and histopathological changes in Alzheimer's disease (AD). Increasing evidence indicates a critical role of cerebrovascular dysfunction in the initiation and progression of AD. Recent studies identified the mechanistic/mammalian target of rapamycin (mTOR) as a critical effector of cerebrovascular dysfunction in AD. mTOR has a key role in the regulation of metabolism, but some mTOR-dependent mechanisms are uniquely specific to the regulation of cerebrovascular function...
January 11, 2018: Gerontology
https://www.readbyqxmd.com/read/29318973/relevance-of-follow-up-in-patients-with-core-clinical-criteria-for-alzheimer-disease-and-normal-csf-biomarkers
#6
Olivier Vercruysse, Claire Paquet, Audrey Gabelle, Xavier Delbeuck, Frederic Blanc, David Wallon, Julien Dumurgier, Eloi Magnin, Olivier Martinaud, Barbara Jung, Olivier Bousiges, Sylvain Lehmann, Constance Delaby, Muriel Quillard-Murain, Katell Peoc'h, Jean-Louis Laplanche, Elodie Bouaziz-Amar, Didier Hannequin, Bernard Sablonniere, Luc Buee, Jacques Hugon, Susanna Schraen, Florence Pasquier, Stephanie Bombois
BACKGROUND: Few patients with a normal cerebrospinal fluid (CSF) biomarker profile fulfill the clinical criteria for Alzheimer disease (AD). OBJECTIVE: The aim of this study was to test the hypothesis of misdiagnoses for these patients. METHOD: Patients from the e-PLM centers fulfilling the core clinical criteria for probable AD dementia or mild cognitive impairment due to AD (AD-MCI), with normal CSF A1-42, T-tau and P-tau biomarkers and clinical follow-up, were included...
January 9, 2018: Current Alzheimer Research
https://www.readbyqxmd.com/read/29310988/an-updated-diagnostic-approach-to-subtype-definition-of-vascular-parkinsonism-recommendations-from-an-expert-working-group
#7
REVIEW
Ivan Rektor, Nicolaas I Bohnen, Amos D Korczyn, Viktoria Gryb, Hrishikesh Kumar, Milica G Kramberger, Frank-Erik de Leeuw, Zvezdan Pirtošek, Irena Rektorová, Ilana Schlesinger, Jaroslaw Slawek, Peter Valkovič, Branislav Veselý
This expert working group report proposes an updated approach to subtype definition of vascular parkinsonism (VaP) based on a review of the existing literature. The persistent lack of consensus on clear terminology and inconsistent conceptual definition of VaP formed the impetus for the current expert recommendation report. The updated diagnostic approach intends to provide a comprehensive tool for clinical practice. The preamble for this initiative is that VaP can be diagnosed in individual patients with possible prognostic and therapeutic consequences and therefore should be recognized as a clinical entity...
December 29, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29301779/what-have-we-learned-from-mr-imaging-in-multiple-sclerosis
#8
REVIEW
E Lapointe, D K B Li, A L Traboulsee, A Rauscher
Using MR imaging, perfusion can be assessed either by dynamic susceptibility contrast MR imaging or arterial spin-labeling. Alterations of cerebral perfusion have repeatedly been described in multiple sclerosis compared with healthy controls. Acute lesions exhibit relative hyperperfusion in comparison with normal-appearing white matter, a finding mostly attributed to inflammation in this stage of lesion development. In contrast, normal-appearing white and gray matter of patients with MS has been mostly found to be hypoperfused compared with controls, and correlations with cognitive impairment as well as fatigue in multiple sclerosis have been described...
January 4, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29299616/increased-variability-of-watershed-areas-in-patients-with-high-grade-carotid-stenosis
#9
Stephan Kaczmarz, Vanessa Griese, Christine Preibisch, Michael Kallmayer, Michael Helle, Isabel Wustrow, Esben Thade Petersen, Hans-Henning Eckstein, Claus Zimmer, Christian Sorg, Jens Göttler
PURPOSE: Watershed areas (WSAs) of the brain are most susceptible to acute hypoperfusion due to their peripheral location between vascular territories. Additionally, chronic WSA-related vascular processes underlie cognitive decline especially in patients with cerebral hemodynamic compromise. Despite of high relevance for both clinical diagnostics and research, individual in vivo WSA definition is fairly limited to date. Thus, this study proposes a standardized segmentation approach to delineate individual WSAs by use of time-to-peak (TTP) maps and investigates spatial variability of individual WSAs...
January 3, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29296213/suppression-of-microrna-9-5p-rescues-learning-and-memory-in-chronic-cerebral-hypoperfusion-rats-model
#10
Na Wei, Kai Zheng, Rui Xue, Sheng-Li Ma, Hua-Yan Ren, Hui-Fen Huang, Wei-Wei Wang, Jing-Jing Xu, Kui-Sheng Chen
Chronic cerebral hypoperfusion has been associated with cognitive impairment in dementias, such as Alzheimer's disease (AD) and vascular disease (VaD), the two most common neurodegenerative diseases in aged people. However, the effective therapeutic approaches for both AD and VaD are still missing. MicroRNAs (miRNAs) are small non-coding RNAs that play important roles in the epigenetic regulation in many neurological disorders; the critical roles of miRNAderegulation had been implicated in both AD and VaD. In the current study, we reported that miR-9-5p is elevated in the serum and cerebrospinalfluid of patientswith VaD...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29285346/subject-specific-multi-poroelastic-model-for-exploring-the-risk-factors-associated-with-the-early-stages-of-alzheimer-s-disease
#11
Liwei Guo, John C Vardakis, Toni Lassila, Micaela Mitolo, Nishant Ravikumar, Dean Chou, Matthias Lange, Ali Sarrami-Foroushani, Brett J Tully, Zeike A Taylor, Susheel Varma, Annalena Venneri, Alejandro F Frangi, Yiannis Ventikos
There is emerging evidence suggesting that Alzheimer's disease is a vascular disorder, caused by impaired cerebral perfusion, which may be promoted by cardiovascular risk factors that are strongly influenced by lifestyle. In order to develop an understanding of the exact nature of such a hypothesis, a biomechanical understanding of the influence of lifestyle factors is pursued. An extended poroelastic model of perfused parenchymal tissue coupled with separate workflows concerning subject-specific meshes, permeability tensor maps and cerebral blood flow variability is used...
February 6, 2018: Interface Focus
https://www.readbyqxmd.com/read/29283444/vasodilator-dysfunction-and-oligodendrocyte-dysmaturation-in-aging-white-matter
#12
Zsolt Bagi, Dieter D Brandner, Phuong Le, David W McNeal, Xi Gong, Huijuan Dou, David J Fulton, Allison Beller, Thuan Ngyuen, Eric B Larson, Thomas J Montine, C Dirk Keene, Stephen A Back
OBJECTIVE: Microvascular brain injury (mVBI) is a common pathologic correlate of vascular contributions to cognitive impairment and dementia (VCID) that leads to white matter injury (WMI). VCID appears to arise from chronic recurrent white matter ischemia that triggers oxidative stress and an increase in total oligodendrocyte lineage cells. We hypothesized that mVBI involves vasodilator dysfunction of white matter penetrating arterioles and aberrant oligodendrocyte progenitor cell (OPC) responses to WMI...
December 28, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29275589/-characteristics-of-cognitive-impairment-and-the-resting-state-functional-mri-in-patients-with-leukoaraiosis
#13
Q Li, L Q Zhao, F Y Hu
Objective: To investigate the features of cognitive impairment and potential physiopathologic mechanism using neuropsychological assessment and resting state functional magnetic resonance imaging (rs-fMRI) in patients with leukoaraiosis (LA). Methods: A total of 13 patients with LA (LA group) and 13 healthy controls (NC group) from Shanxi Provincial People's Hospital between January and June 2016 were recruited. The two groups were matched for age, sex, education, and vascular risk factors. All the subjects underwent neuropsychological assessment and the scan of rs-fMRI...
December 5, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29273521/the-pathology-and-pathophysiology-of-vascular-dementia
#14
REVIEW
Raj N Kalaria
Vascular dementia (VaD) is widely recognised as the second most common type of dementia. Consensus and accurate diagnosis of clinically suspected VaD relies on wide-ranging clinical, neuropsychological and neuroimaging measures in life but more importantly pathological confirmation. Factors defining subtypes of VaD include the nature and extent of vascular pathologies, degree of involvement of extra and intracranial vessels and the anatomical location of tissue changes as well as time after the initial vascular event...
December 19, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29261519/diabetic-retinopathy-and-dementia-in-type-1-diabetes
#15
Liora G Rodill, Lieza G Exalto, Paola Gilsanz, Geert Jan Biessels, Charles P Quesenberry, Rachel A Whitmer
OBJECTIVE: Retinopathy impacts over one-third of those with diabetes mellitus and is associated with impaired cognitive performance and cerebrovascular lesions in middle-aged adults with type 1 diabetes. However, the association between diabetic retinopathy (DR) and risk of dementia in type 1 diabetes is unknown. We investigated the association between DR and incident dementia in a large, elderly population with type 1 diabetes. METHODS: A cohort of 3742 patients with type 1 diabetes aged 50 years and above was followed from January 1, 1996 to September 30, 2015 for incident dementia...
December 19, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29260027/does-cerebral-large-artery-disease-contribute-to-cognitive-impairment
#16
Satoshi Kimura, Toshiyasu Ogata, Junko Watanabe, Tooru Inoue, Yoshio Tsuboi
Purpose: Although many patients with cerebral large-artery disease (CLAD) show impaired cognitive performance, the risk factors remain unclear in this population. The objective of this study was to evaluate cognitive impairment and its risk factors in patients with CLAD. Methods: We recruited non-demented patients with CLAD from our hospital. CLAD was defined as occlusion or stenosis of over 50% in the carotid artery or middle cerebral artery. We collected patients' biographical data and vascular lesion and imaging data, including periventricular hyperintensity (PVH) and cerebral perfusion...
September 2017: ENeurologicalSci
https://www.readbyqxmd.com/read/29248560/vegf-attenuates-2-vo-induced-cognitive-impairment-and-neuronal-injury-associated-with-the-activation-of-pi3k-akt-and-notch1-pathway
#17
Ling Wang, Faqi Wang, Shuang Liu, Xuening Yang, Jiajia Yang, Dong Ming
Vascular endothelial growth factor (VEGF) has been identified as a potential treatment for effectively improving cognitive function in several neuropathological conditions. However, the underlying mechanism and the relevant downstream protective pathways that are activated in neurons by VEGF remain elusive, especially in chronic global cerebral ischemia. In this study, we intended to investigate the signaling mechanisms of VEGF in cognitive protection and anti-apoptosis in a rat model of chronic global cerebral ischemia induced by permanent bilateral common carotid artery occlusion (2-VO)...
December 14, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29247390/cognitive-impairment-in-celiac-disease-and-non-celiac-gluten-sensitivity-review-of-literature-on-the-main-cognitive-impairments-the-imaging-and-the-effect-of-gluten-free-diet
#18
REVIEW
Sinda Makhlouf, Mariem Messelmani, Jamel Zaouali, Ridha Mrissa
Celiac disease (CD) and non celiac gluten sensitivity (NCGS) can be responsible for neurological complications such as ataxia and peripheral neuropathies but also cognitive impairment. This cognitive involvement is variable in its expression, its duration and its prognosis ranging from transient and reversible subtle involvement to dementia itself. Through this article, we tried to achieve a review of the literature to better understand this topic. Several mechanisms were proposed to explain the deleterious influence of gluten-related pathologies on cognitive functions: nutritional deficiencies, elevation of circulating cytokine levels due to systemic inflammation, low brain serotonin levels… Several types of dementia such as Alzheimer dementia, vascular dementia, frontotemporal dementia were reported in association with CD...
December 15, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29244126/silent-cerebral-small-vessel-disease-twice-as-prevalent-in-middle-aged-well-controlled-cart-treated-hiv-infected-individuals-than-hiv-uninfected-individuals
#19
Antoine Moulignier, Julien Savatovsky, Lambert Assoumou, François-Xavier Lescure, Cédric Lamirel, Ophelia Godin, Nadia Valin, Roland Tubiana, Ana Canestri, Pascal Roux, Jean-Claude Sadik, Laurence Salomon, Marie Abrivard, Christine Katlama, Yazdan Yazdanpanah, Gilles Pialoux, Pierre-Marie Girard, Dominique Costagliola
Background: Silent cerebral small-vessel disease (CSVD) is defined as white matter hyperintensities, silent brain infarction or microbleeds. CSVD is responsible for future vascular events, cognitive impairment, frailty and shorter survival. CSVD prevalence among middle-aged persons living with well-controlled HIV infection (PLHIVs) is unknown. Methods: ANRS EP51 MicroBREAK (NCT02082574) is a cross-sectional study with prospective enrollment of treated PLHIVs, ≥50 years old with viral load controlled for ≥12 months, and frequency age- and sex-matched HIV-uninfected controls (HUCs)...
December 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29241675/effect-of-telmisartan-on-preventing-learning-and-memory-deficits-via-peroxisome-proliferator-activated-receptor-%C3%AE-in-vascular-dementia-spontaneously-hypertensive-rats
#20
Yuan Gao, Wei Li, Yali Liu, Yan Wang, Jianchao Zhang, Miao Li, Mengsen Bu
BACKGROUND: This study aimed to explore the effect of telmisartan (TEL), as a partial peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, in vascular dementia (VaD) rats induced by middle cerebral artery occlusion (MCAO). METHODS: Spontaneously hypertensive rats were divided into 6 groups: the sham group, model group, TEL-treated groups (1, 5, and 10 mg/kg), and TEL + GW9662 (10 mg/kg + 1 mg/kg). Using the MCAO method established the VaD rat model...
December 11, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
keyword
keyword
83214
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"