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Biomaterials

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https://www.readbyqxmd.com/read/27932701/synthesis-and-characterization-of-fluorescein-grafted-polyurethane-for-potential-application-in-biomedical-tracing
#1
Boyuan Yang, Qin Zou, Lili Lin, Limei Li, Yi Zuo, Yubao Li
Redesigned multifunctional biopolymers represent a novel building bridge for interdisciplinary collaborations in biomaterials development. We prepared fluorescein-grafted polyurethane scaffolds (PU-C1, PU-C5, and PU-B1) to meet both clinical needs and biological safety evaluations, using different contents of calcein and different synthesis procedures for potential biomedical tracing. X-ray diffraction, infrared, X-ray photoelectron spectroscopy, nuclear magnetic resonance, scanning electron microscopy, and light microscopy were used to analyze the composition and structure of polyurethanes, as well as to observe their morphology with and without biomarkers...
December 8, 2016: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/27931176/in-vitro-evaluation-of-electrospun-silk-fibroin-nano-hydroxyapatite-bmp-2-scaffolds-for-bone-regeneration
#2
Bingjie Niu, Bin Li, Yong Gu, Xiaofeng Shen, Yong Liu, Liang Chen
Bone tissue engineering by using osteoinductive scaffolds seeded with stem cells to promote bone extracellular matrix (ECM) production and remodeling has evolved into a promising approach for bone repair and regeneration. In order to mimic the ECM of bone tissue structurally and compositionally, nanofibrous silk fibroin (SF) scaffolds containing hydroxyapatite (HAP) nanoparticles and bone morphogenetic protein 2 (BMP-2) were fabricated in this study using electrospinning technique. The microstructure, mechanical property, biocompatibility, and osteogenic characteristics were examined...
December 9, 2016: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/27930404/sandwich-osteotomies-to-treat-vertical-defects-of-the-alveolar-ridge
#3
Claudio Ferreira Nóia, Rafael Ortega-Lopes, Leandro Eduardo Kluppel, Bruno Costa Martins de Sá
PURPOSE: To evaluate the vertical bone gain after osteotomy sandwich. MATERIALS AND METHODS: Fourteen patients (mean age, 41 years) underwent 17 procedures of osteotomy sandwich. Of these 17 procedures, 15 involved reconstructive surgery and 2 involved the repositioning of implants. The patients were submitted to computed tomography before the surgical procedure and 4 months after the completion of the graft, with measurements taken to assess the vertical gain that had been achieved...
December 7, 2016: Implant Dentistry
https://www.readbyqxmd.com/read/27929801/preparation-of-native-cellulose-agcl-fiber-with-antimicrobial-activity-through-one-step-electrospinning
#4
Shaojun Wang, Xiaomin Zhang, Ting Luo, Jin Zhu, Shengpei Su
The native Cellulose-AgCl fiber have been firstly fabricated by one-step electrospinning of cellulose solution with poly(vinyl pyrrolidone) (PVP) and AgNO3. X-ray diffraction (XRD), Scanning electron microscopy (SEM), Energy dispersive spectrometer (EDS), Thermo-gravimetric analysis (TGA) and Fourier transform infrared (FT-IR) are used to characterize the crystal structure, morphology and composition of cellulose-AgCl nanocomposites. The results of SEM indicate that the size of AgCl in cellulose fiber matrix is able to be adjusted by the addition of Polyvinylpyrrolidone(PVP)...
December 8, 2016: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/27929692/osteoporotic-animal-models-of-bone-healing-advantages-and-pitfalls
#5
Elena Calciolari, Nikolaos Donos, Nikos Mardas
The aim of this review was to summarize the advantages and pitfalls of the available osteoporotic animal models of bone healing. A thorough literature search was performed in MEDLINE via OVID and EMBASE to identify animal studies investigating the effect of experimental osteoporosis on bone healing and bone regeneration. The osteotomy model in the proximal tibia is the most popular osseous defect model to study the bone healing process in osteoporotic-like conditions, although other well-characterized models, such as the post-extraction model, might be taken into consideration by future studies...
December 8, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/27929027/vascular-diseases-shear-thinning-biomaterial-for-endovascular-embolization
#6
Karina Huynh
No abstract text is available yet for this article.
December 8, 2016: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/27925678/two-dimensional-and-three-dimensional-ultrasound-of-artificial-skin
#7
Ximena Wortsman, Nelson Navarrete
Wound healing may be a difficult problem, and variable types of artificial skin prototypes have been developed for supporting this process. Using ultrasound, we studied 4 cellulose-derived artificial skin prototypes and assessed their two-dimensional and three-dimensional morphology. These prototypes were identified on ultrasound both on in vitro and in vivo studies. They allowed the sonographic observation of deeper layers on different types of surfaces of the body with good definition on the in vivo examinations performed on healthy skin and cutaneous ulcers...
November 30, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27925461/in-it-for-the-long-haul-the-cytocompatibility-of-aged-graphene-oxide-and-its-degradation-products
#8
Brian D Holt, Anne M Arnold, Stefanie A Sydlik
Synthetic biomaterials are poised to transform medicine; however, current synthetic options have yet to ideally recapitulate the desirable properties of native tissue. Thus, the development of new synthetic biomaterials remains an active challenge. Due to its excellent properties, including electrical conductivity, water dispersibility, and capacity for functionalization, graphene oxide (GO) holds potential for myriads of applications, including biological devices. While many studies have evaluated the compatibility of freshly prepared GO, understanding the compatibility of GO as it ages in an aqueous environment is crucial for its safe implementation in long-term biological applications...
December 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27924840/atmospheric-pressure-non-equilibrium-plasma-as-a-green-tool-to-crosslink-gelatin-nanofibers
#9
Anna Liguori, Adriana Bigi, Vittorio Colombo, Maria Letizia Focarete, Matteo Gherardi, Chiara Gualandi, Maria Chiara Oleari, Silvia Panzavolta
Electrospun gelatin nanofibers attract great interest as a natural biomaterial for cartilage and tendon repair despite their high solubility in aqueous solution, which makes them also difficult to crosslink by means of chemical agents. In this work, we explore the efficiency of non-equilibrium atmospheric pressure plasma in stabilizing gelatin nanofibers. We demonstrate that plasma represents an innovative, easy and environmentally friendly approach to successfully crosslink gelatin electrospun mats directly in the solid state...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27924445/growth-arrest-of-vascular-smooth-muscle-cells-in-suspension-culture-using-low-acyl-gellan-gum
#10
Tomomi Natori, Masachika Fujiyoshi, Masashi Uchida, Natsuki Abe, Tatsuro Kanaki, Yasunori Fukumoto, Itsuko Ishii
The proliferation of vascular smooth muscle cells (SMCs) causes restenosis in biomaterial vascular grafts. The purposes of this study were to establish a suspension culture system for SMCs by using a novel substrate, low-acyl gellan gum (GG) and to maintain SMCs in a state of growth inhibition. When SMCs were cultured in suspension with GG, their proliferation was inhibited. Their viability was 70% at day 2, which was maintained at more than 50% until day 5. In contrast, the viability of cells cultured in suspension without GG was 5...
December 6, 2016: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/27919809/effect-of-novel-bioactive-edible-coatings-based-on-jujube-gum-and-nettle-oil-loaded-nanoemulsions-on-the-shelf-life-of-beluga-sturgeon-fillets
#11
Seyed Mohammad Taghi Gharibzahedi, Sara Mohammadnabi
Effect of jujube gum (JG; 4, 8 and 12% wt)-based nanoemulsions (NEs) containing nettle essential oil (NEO; 2, 3.5 and 5% wt) as new edible coatings was investigated to preserve Beluga sturgeon fillets (BSFs) during 15 day-refrigerated storage at 4°C. Physical (weight loss, cooking loss, color and texture), chemical (pH, FFA, PV, TBARS and TVB-N), microbiological (total and psychrotrophic bacterial counts), and sensorial characteristics of BSFs were kinetically analyzed. Preliminary studies showed that the NEs formulated with NEO lower than 5% at all JG concentrations were able to form stable coating solutions owing to the highest short-term stability (>90%) and entrapment efficiency (94...
December 2, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27919386/donor-s-support-tool-enabling-informed-secondary-use-of-patient-s-biomaterial-and-personal-data
#12
Haridimos Kondylakis, Lefteris Koumakis, Stephanie Hänold, Iheanyi Nwankwo, Nikolaus Forgó, Kostas Marias, Manolis Tsiknakis, Norbert Graf
PURPOSE: Biomedical research is being catalyzed by the vast amount of data rapidly collected through the application of information technologies (IT). Despite IT advances, the methods for involving patients and citizens in biomedical research remain static, paper-based and organized around national boundaries and anachronistic legal frameworks. The purpose of this paper is to study the current practices for obtaining consent for biobanking and the legal requirements for reusing the available biomaterial and data in EU and finally to present a novel tool to this direction enabling the secondary use of data and biomaterial...
January 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27919214/hydrogel-based-drug-delivery-systems-a-review-with-special-emphasis-on-challenges-associated-with-decontamination-of-hydrogels-and-biomaterials
#13
Irene Satiko Kikuchi, Raquel Galante, Kamal Dua, Daniela Dal Molim Ghisleni, Terezinha de Jesus Andreoli Pinto, Venkata Ramana Malipeddi, Rajendra Awasthi
Many researches involving the development of new techniques and biomaterials to formulate a suitable drug delivery systems and tissue engineering have been conducted. The majority of published literature from these researches emphasizes the production and materials characterization. However there is very limited information regarding their sterilization methods. The present review article has summarized various different literatures that encompasses the difficulties encountered with sterilization methods in the preparations of hydrogels for biological applications...
December 5, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27919066/designed-proteins-induce-the-formation-of-nanocage-containing-extracellular-vesicles
#14
Jörg Votteler, Cassandra Ogohara, Sue Yi, Yang Hsia, Una Nattermann, David M Belnap, Neil P King, Wesley I Sundquist
Complex biological processes are often performed by self-organizing nanostructures comprising multiple classes of macromolecules, such as ribosomes (proteins and RNA) or enveloped viruses (proteins, nucleic acids and lipids). Approaches have been developed for designing self-assembling structures consisting of either nucleic acids or proteins, but strategies for engineering hybrid biological materials are only beginning to emerge. Here we describe the design of self-assembling protein nanocages that direct their own release from human cells inside small vesicles in a manner that resembles some viruses...
November 30, 2016: Nature
https://www.readbyqxmd.com/read/27918986/hybrid-chitosan-polyaniline-polypyrrole-biomaterial-for-enhanced-adsorption-and-antimicrobial-activity
#15
Rajeev Kumar, Mohammad Oves, Talla Ameelbi, Naief H Al-Makishah, M A Barakat
In this work, chitosan (CS) functionalized polyaniline-polypyrrole (Pani-Ppy) copolymer (CS/Pani-Ppy) was synthesized applying a facile one pot method for the enhanced adsorption of Zn(II) and antimicrobial activity for E. coli and E. agglomerans. The synthesized materials were characterized using scanning electron microscopy, energy dispersive X-ray spectroscopy, Fourier transform inferred spectroscopy and X-ray photoelectron spectroscopy. The adsorption of the Zn(II) on the synthesized materials was highly dependent on the pH of the solution, the initial metal ion concentration, and temperature...
November 24, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27918936/promoting-angiogenesis-with-mesoporous-microcarriers-through-a-synergistic-action-of-delivered-silicon-ion-and-vegf
#16
Khandmaa Dashnyam, Guang-Zhen Jin, Joong-Hyun Kim, Roman Perez, Jun-Hyeog Jang, Hae-Won Kim
Angiogenic capacity of biomaterials is a key asset to drive vascular ingrowth during tissue repair and regeneration. Here we design a unique angiogenic microcarrier based on sol-gel derived mesoporous silica. The microspheres offer a potential angiogenic stimulator, Si ion, 'intrinsically' within the chemical structure. Furthermore, the highly mesoporous nature allows the loading and release of angiogenic growth factor 'extrinsically'. The Si ion is released from the microcarriers at therapeutic ranges (over a few ppm per day), which indeed up-regulates the expression of hypoxia inducing factor 1α (HIF1α) and stabilizes it by blocking HIF-prolyl hydroxylase 2 (PHD2) in HUVECs...
November 28, 2016: Biomaterials
https://www.readbyqxmd.com/read/27918020/effects-of-ovalbumin-protein-nanoparticle-vaccine-size-and-coating-on-dendritic-cell-processing
#17
Timothy Z Chang, Samantha S Stadmiller, Erika Staskevicius, Julie A Champion
Nanoparticle vaccine delivery platforms are a promising technology for enhancing vaccine immunogenicity. Protein nanoparticles (PNPs), made entirely from antigen, have been shown to induce protective immune responses against influenza. However, the fundamental mechanisms by which PNPs enhance component protein immunogenicity are not understood. Here, we investigate the role of size and coating of model ovalbumin (OVA) PNPs on particle uptake and trafficking, as well as on inflammation and maturation factor expression in dendritic cells (DCs) in vitro...
December 5, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27917703/principles-of-the-kenzan-method-for-robotic-cell-spheroid-based-3d-bioprinting
#18
Nicanor I Moldovan, Narutoshi Hibino, Koichi Nakayama
Bioprinting is a technology with the prospect to change the way many diseases are treated, by replacing the damaged tissues with live, de novo created bio-similar constructs. However, after more than a decade of incubation and many proofs-of-concept, the field is still in its infancy. The current stagnation is the consequence of its early success: the first bioprinters, and most of those which followed, were modified versions of the 3D printers used in additive manufacturing, redesigned for layer-by-layer dispersion of biomaterials...
December 4, 2016: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27917250/in-plane-microvortices-micromixer-based-ac-electrothermal-for-testing-drug-induced-death-of-tumor-cells
#19
Qi Lang, Yukun Ren, Divia Hobson, Ye Tao, Likai Hou, Yankai Jia, Qingming Hu, Jiangwei Liu, Xin Zhao, Hongyuan Jiang
Herein, we first describe a perfusion chip integrated with an AC electrothermal (ACET) micromixer to supply a uniform drug concentration to tumor cells. The in-plane fluid microvortices for mixing were generated by six pairs of reconstructed novel ACET asymmetric electrodes. To enhance the mixing efficiency, the novel ACET electrodes with rotating angles of 0°, 30°, and 60° were investigated. The asymmetric electrodes with a rotating angle of 60° exhibited the highest mixing efficiency by both simulated and experimental results...
November 2016: Biomicrofluidics
https://www.readbyqxmd.com/read/27917179/evaluation-of-relationships-between-growth-rate-tree-size-lignocellulose-composition-and-enzymatic-saccharification-in-interspecific-corymbia-hybrids-and-parental-taxa
#20
Adam L Healey, David J Lee, Jason S Lupoi, Gabriella Papa, Joel M Guenther, Luca Corno, Fabrizio Adani, Seema Singh, Blake A Simmons, Robert J Henry
In order for a lignocellulosic bioenergy feedstock to be considered sustainable, it must possess a high rate of growth to supply biomass for conversion. Despite the desirability of a fast growth rate for industrial application, it is unclear what effect growth rate has on biomass composition or saccharification. We characterized Klason lignin, glucan, and xylan content with response to growth in Corymbia interspecific F1 hybrid families (HF) and parental species Corymbia torelliana and C. citriodora subspecies variegata and measured the effects on enzymatic hydrolysis from hydrothermally pretreated biomass...
2016: Frontiers in Plant Science
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