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Biomaterials

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https://www.readbyqxmd.com/read/29160793/a-gal-m%C3%A2%C2%B5s-device-to-evaluate-cell-migratory-response-to-combined-galvano-chemotactic-fields
#1
Shawn Mishra, Maribel Vazquez
Electric fields have been studied extensively in biomedical engineering (BME) for numerous regenerative therapies. Recent studies have begun to examine the biological effects of electric fields in combination with other environmental cues, such as tissue-engineered extracellular matrices (ECM), chemical gradient profiles, and time-dependent temperature gradients. In the nervous system, cell migration driven by electrical fields, or galvanotaxis, has been most recently studied in transcranial direct stimulation (TCDS), spinal cord repair and tumor treating fields (TTF)...
November 21, 2017: Biosensors
https://www.readbyqxmd.com/read/29160706/synthesis-and-characterization-of-ultralow-fouling-poly-n-acryloyl-glycinamide-brushes
#2
Fengyu Yang, Yonglan Liu, Yanxian Zhang, Baiping Ren, Jianxiong Xu, Jie Zheng
Rational design of biomaterials with antifouling properties still remains a challenge, but is important for many bench-to-bedside applications for biomedical implants, drug delivery carriers, and marine coatings. Herein we synthesized and characterized poly(N-acryloylglycinamide) (polyNAGA) and then grafted poly(NAGA) onto Au substrate to form polymer brushes with well controlled film stability, wettability and thickness using the surface-initiated atom transfer radical polymerization (SI-ATRP). The NAGA monomer integrates two hydrophilic amides on the side chain to enhance surface hydration, which is thought as a critical contributor to antifouling property...
November 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29160686/human-hair-keratin-for-biocompatible-flexible-and-transient-electronic-devices
#3
Jieun Ko, Luong Thi Hieun Nguyen, Abhijith Surendran, Bee Yi Tan, Kee Woei Ng, Wei Lin Leong
Biomaterials have been attracting attention as a useful building block for biocompatible and bioresorbable electronics due to its non-toxic property and solution processabillity. In this work, we report the integration of biocompatible keratin from human hair as dielectric layer for organic thin-film transistors (TFTs), with high performance, flexibility and transient property. The keratin dielectric layer exhibited a high capacitance value above 1.27 μF/cm2 at 20 Hz due to the formation of electrical double layer...
November 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29160638/tissue-repair-in-neonatal-and-pediatric-surgery-analysis-on-infections-in-surgically-implanted-natural-biomaterials
#4
Amulya K Saxena, Piotr Soltysiak
INTRODUCTION: Over the past 4 decades commercially available natural and synthetic biomaterials have been employed for various reconstructive procedures in the pediatric population. The aim of this study was to identify the types of commercially available natural biomaterials and their areas of application in the pediatric age group. Furthermore, to perform an analysis to identify areas of application and types of biomaterials those have increased susceptibility to infections in the pediatric population...
November 21, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/29160149/in-vitro-and-in-vivo-evaluation-of-silk-fibroin-functionalized-with-gaba-and-allopregnanolone-for-schwann-cell-and-neuron-survival
#5
Chiara Gm Gennari, Francesco Cilurzo, Nico Mitro, Donatella Caruso, Paola Minghetti, Valerio Magnaghi
AIM: This in vitro and in vivo study reports on silk fibroin (SF) scaffold, functionalized for in situ delivery of GABA and/or allopregnanolone (ALLO), as biomaterial for potential application in tissue engineering and nerve regeneration. MATERIALS & METHODS: We evaluated the feasibility to design 2D scaffolds (films) made of regenerated Bombyx mori SF, functionalized with GABA and/or ALLO to enhance in vitro biological functions, health, survival and growth of Schwann cells and sensitive neurons of the dorsal root ganglia...
November 21, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/29159895/proliferation-and-differentiation-of-mesenchymal-stem-cells-on-scaffolds-containing-chitosan-calcium-polyphosphate-and-pigeonite-for-bone-tissue-engineering
#6
S Dhivya, A Keshav Narayan, R Logith Kumar, S Viji Chandran, M Vairamani, N Selvamurugan
OBJECTIVES: Treatment of critical-sized bone defects with cells and biomaterials offers an efficient alternative to traditional bone grafts. Chitosan (CS) is a natural biopolymer that acts as a scaffold in bone tissue engineering (BTE). Polyphosphate (PolyP), recently identified as an inorganic polymer, acts as a potential bone morphogenetic material, whereas pigeonite (Pg) is a novel iron-containing ceramic. In this study, we prepared and characterized scaffolds containing CS, calcium polyphosphate (CaPP) and Pg particles for bone formation in vitro and in vivo...
November 21, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/29159831/design-and-development-of-low-cost-polyurethane-biopolymer-based-on-castor-oil-and-glycerol-for-biomedical-applications
#7
A C W Tan, B J Polo-Cambronell, E Provaggi, C Ardila-Suárez, G E Ramirez-Caballero, V G Baldovino-Medrano, D M Kalaskar
In the current study, we present the synthesis of novel low cost bio-polyurethane compositions with variable mechanical properties based on castor oil and glycerol for biomedical applications. A detailed investigation of the physicochemical properties of the polymer was carried out by using mechanical testing, ATR-FTIR, and X-ray photoelectron spectroscopy (XPS). Polymers were also tested in short term in-vitro cell culture with human mesenchymal stem cells to evaluate their biocompatibility for potential applications as biomaterial...
November 21, 2017: Biopolymers
https://www.readbyqxmd.com/read/29159587/teaching-an-old-pet-new-tricks-tuning-of-inclusion-body-formation-and-properties-by-a-mixed-feed-system-in-e-coli
#8
David J Wurm, Julian Quehenberger, Julia Mildner, Britta Eggenreich, Christoph Slouka, Andreas Schwaighofer, Karin Wieland, Bernhard Lendl, Vignesh Rajamanickam, Christoph Herwig, Oliver Spadiut
Against the outdated belief that inclusion bodies (IBs) in Escherichia coli are only inactive aggregates of misfolded protein, and thus should be avoided during recombinant protein production, numerous biopharmaceutically important proteins are currently produced as IBs. To obtain correctly folded, soluble product, IBs have to be processed, namely, harvested, solubilized, and refolded. Several years ago, it was discovered that, depending on cultivation conditions and protein properties, IBs contain partially correctly folded protein structures, which makes IB processing more efficient...
November 20, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29159332/a-biomaterial-screening-approach-reveals-microenvironmental-mechanisms-of-drug-resistance
#9
Alyssa D Schwartz, Lauren E Barney, Lauren E Jansen, Thuy V Nguyen, Christopher L Hall, Aaron S Meyer, Shelly R Peyton
Traditional drug screening methods lack features of the tumor microenvironment that contribute to resistance. Most studies examine cell response in a single biomaterial platform in depth, leaving a gap in understanding how extracellular signals such as stiffness, dimensionality, and cell-cell contacts act independently or are integrated within a cell to affect either drug sensitivity or resistance. This is critically important, as adaptive resistance is mediated, at least in part, by the extracellular matrix (ECM) of the tumor microenvironment...
November 21, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/29159178/zinc-containing-hydroxyapatite-enhances-cold-light-activated-tooth-bleaching-treatment-in-vitro
#10
Yi Li, Xinchang Shi, Wei Li
Cold-light bleaching treatment has grown to be a popular tooth whitening procedure in recent years, but its side effect of dental enamel demineralization is a widespread problem. The aim of this study was to synthesize zinc-substituted hydroxyapatite as an effective biomaterial to inhibit demineralization or increase remineralization. We synthesized zinc-substituted hydroxyapatite containing different zinc concentrations and analysed the product using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and energy dispersive spectrometer (EDS)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29158995/the-role-of-biomaterials-in-the-treatment-of-meniscal-tears
#11
Crystal O Kean, Robert J Brown, James Chapman
Extensive investigations over the recent decades have established the anatomical, biomechanical and functional importance of the meniscus in the knee joint. As a functioning part of the joint, it serves to prevent the deterioration of articular cartilage and subsequent osteoarthritis. To this end, meniscus repair and regeneration is of particular interest from the biomaterial, bioengineering and orthopaedic research community. Even though meniscal research is previously of a considerable volume, the research community with evolving material science, biology and medical advances are all pushing toward emerging novel solutions and approaches to the successful treatment of meniscal difficulties...
2017: PeerJ
https://www.readbyqxmd.com/read/29157911/enhanced-activity-and-stability-of-industrial-lipases-immobilized-onto-spherelike-bacterial-cellulose
#12
Qingqing Cai, Chengbo Hu, Na Yang, Qingshan Wang, Jianying Wang, Haobo Pan, Yang Hu, Changshun Ruan
This study focused on improving activity and stability of industrial lipases by means of enzymatic immobilization onto spherelike bacterial cellulose (SBC) newly synthesized by a particular bacterial strain (Gluconacetobacter xylinus, JCM 9730). The results revealed that immobilizing lipases onto aldehyde-modified SBC with a size of 6.10±0.50mm could lead to two optimal hydrolytic activities of lipases under both acidic (pH 5) and alkaline conditions (pH 8), which was superior to free lipases that only exhibited an alkaline activity at pH 9...
November 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29157289/vitamin-c-plus-hydrogel-facilitates-bone-marrow-stromal-cell-mediated-endometrium-regeneration-in-rats
#13
Huan Yang, Su Wu, Ran Feng, Junjiu Huang, Lixiang Liu, Feng Liu, Yuqing Chen
BACKGROUND: Intrauterine adhesion (IUA) is a common uterine cavity disease which can be caused by mechanical damage that may eventually lead to infertility and pregnancy abnormalities. Since the effect of therapeutic drugs appears disappointing, cell therapy has emerged as an alternative choice for endometrium regeneration. The aim of this study is to investigate whether the combination of hydrogel Pluronic F-127 (PF-127), Vitamin C (Vc), and a bone marrow stromal cell (BMSC) mixture could be a feasible strategy to improve the endometrial regeneration in a mechanical damage model of IUA in rats...
November 21, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29156809/adipose-derived-stem-cells-seeded-bladder-acellular-matrix-graft-silk-fibroin-enhances-bladder-reconstruction-in-a-rat-model
#14
Dongdong Xiao, Qiong Wang, Hao Yan, Xiangguo Lv, Yang Zhao, Zhe Zhou, Ming Zhang, Qian Sun, Kang Sun, Wei Li, Mujun Lu
The unfavourable clinical outcomes of host cell-seeded scaffolds for bladder augmentation warrant improved bioactive biomaterials. This study aimed to examine the feasibility of adipose-derived stem cells (ASCs)-seeded bilayer bladder acellular matrix graft (BAMG)-silk fibroin (SF) scaffold in enhancing bladder reconstruction. Sprague Dawley rats were randomly divided into three groups: the BAMG-SF-ASCs group, the acellular BAMG-SF group and the cystotomy group. The BAMG-SF-ASCs group was sampled at 2, 4 and 12 weeks, and compared with the other groups at 12 weeks...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156629/reconstruction-of-craniomaxillofacial-bone-defects-using-tissue-engineering-strategies-with-injectable-and-non-injectable-scaffolds
#15
REVIEW
Bipin Gaihre, Suren Uswatta, Ambalangodage C Jayasuriya
Engineering craniofacial bone tissues is challenging due to their complex structures. Current standard autografts and allografts have many drawbacks for craniofacial bone tissue reconstruction; including donor site morbidity and the ability to reinstate the aesthetic characteristics of the host tissue. To overcome these problems; tissue engineering and regenerative medicine strategies have been developed as a potential way to reconstruct damaged bone tissue. Different types of new biomaterials; including natural polymers; synthetic polymers and bioceramics; have emerged to treat these damaged craniofacial bone tissues in the form of injectable and non-injectable scaffolds; which are examined in this review...
November 20, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29156291/engineering-the-next-generation-tin-containing-%C3%AE-titanium-alloys-with-high-strength-and-low-modulus-for-orthopedic-applications
#16
Sumit Bahl, Suvam Das, Satyam Suwas, Kaushik Chatterjee
Metastable β Ti alloys are the new emerging class of biomaterial for load bearing orthopedic applications. However, these alloys in the single β phase microstructure have insufficient strength for use in load bearing applications. It is imperative to strengthen these alloys by carefully designed thermo-mechanical processing routes that typically involve aging treatment. In this investigation two newly designed Sn based β Ti alloys of composition Ti-32Nb-(2, 4) Sn are evaluated. The effects of Sn content on the mechanical properties and biological performance of these alloys processed through designed thermo-mechanical processing route are investigated...
November 11, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29156290/understanding-hydration-effects-on-mechanical-and-impacting-properties-of-turtle-shell
#17
Xu Zhang, Zhen-Bing Cai, Wei Li, Min-Hao Zhu
Study of the properties of natural biomaterials provides a reliable experimental basis for the design of biomimetic materials. The mechanical properties and impact wear behaviors of turtle shell with different soaking time were investigated on a micro-amplitude impact wear tester. The damage behavior of turtle shells with different soaking time and impact cycles were systematically analyzed, also the impact dynamics behavior was inspected during the impact wear progress. The results showed that the energy absorption and impact contact force were significantly different with varied soaking time...
November 10, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29155557/wearable-nanoplasmonic-patch-detecting-sun-uv-exposure
#18
Jessica G Barajas-Carmona, Leydi Francisco-Aldana, Eden Morales-Narváez
Sun exposure is known to yield beneficial health outcomes, including synthesis of adequate levels of vitamin D, beneficial modulation of blood pressure and is a valuable factor in mental health care. However, the increasing incidence of sun/UV exposure-related illness, such as skin cancer, is seriously concerning public health authorities as well as the scientific community. Consequently, moderate sun/UV exposure is strongly recommended. A wearable nanoplasmonic patch whose original color changes upon sun exposure due to its UV-responsive capabilities that are visually detectable has been engineered...
November 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29155409/biomaterial-strategies-for-limiting-the-impact-of-secondary-events-following-spinal-cord-injury
#19
Trevor R Ham, Nic D Leipzig
The nature of traumatic spinal cord injury (SCI) often involves limited recovery and long-term quality of life complications. The initial injury sets off a variety of secondary cascades, which result in an expanded lesion area. Ultimately, the native tissue fails to regenerate. As treatments are developed in the laboratory, the management of this secondary cascade is an important first step in achieving recovery of normal function. Current literature identifies four broad targets for intervention: inflammation, oxidative stress, disruption of the blood-spinal cord barrier, and formation of an inhibitory glial scar...
November 20, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/29155396/biomimetic-synthesis-of-silver-nanoparticles-from-streptomyces-atrovirens-and-their-potential-anticancer-activity-against-human-breast-cancer-cells
#20
Ramasamy Subbaiya, Muthupandian Saravanan, Andavar Raja Priya, Konathala Ravi Shankar, Masilamani Selvam, Muhammad Ovais, Ramachandran Balajee, Hamed Barabadi
Silver nanoparticles (AgNPs) have been undeniable for its antimicrobial activity while its antitumour potential is still limited. Therefore, the present study focused on determining cytotoxic effects of AgNPs on Michigan cancer foundation-7 (MCF-7) breast cancer cells and its corresponding mechanism of cell death. Herein, the authors developed a bio-reduction method for AgNPs synthesis using actinomycetes isolated from marine soil sample. The isolated strain was identified by 16s ribotyping method and it was found to be Streptomyces atrovirens...
December 2017: IET Nanobiotechnology
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