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https://www.readbyqxmd.com/read/29298856/persistent-pulmonary-hypertension-of-the-newborn-in-extremely-preterm-infants-a-japanese-cohort-study
#1
Hidehiko Nakanishi, Hideyo Suenaga, Atsushi Uchiyama, Satoshi Kusuda
OBJECTIVE: To investigate the characteristics of persistent pulmonary hypertension of the newborn (PPHN) in extremely preterm infants and its impact on neurodevelopmental outcomes at 3 years of age. DESIGN: A retrospective multicentre cohort study. SETTINGS: 202 tertiary perinatal centres registered in the Neonatal Research Network of Japan (NRNJ). PATIENTS: Infants born at <28 weeks of gestational age (GA), between 2003 and 2012, were extracted from tertiary perinatal centres participating in NRNJ...
January 3, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29297352/tackling-the-hard-problems-implementation-experience-and-lessons-learned-in-newborn-health-from-the-african-health-initiative
#2
Hema Magge, Roma Chilengi, Elizabeth F Jackson, Bradley H Wagenaar, Almamy Malick Kante
BACKGROUND: The Doris Duke Charitable Foundation's African Health Initiative supported the implementation of Population Health Implementation and Training (PHIT) Partnership health system strengthening interventions in designated areas of five countries: Ghana, Mozambique, Rwanda, Tanzania, and Zambia. All PHIT programs included health system strengthening interventions with child health outcomes from the outset, but all increasingly recognized the need to increase focus to improve health and outcomes in the first month of life...
December 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29282018/why-gone-too-soon-examining-social-determinants-of-neonatal-deaths-in-northwest-ethiopia-using-the-three-delay-model-approach
#3
Tariku Nigatu Bogale, Abebaw Gebeyehu Worku, Gashaw Andargie Bikis, Zemene Tigabu Kebede
BACKGROUND: Without improving the survival of newborns, meaningful reduction in under-five mortality is difficult. Most neonatal deaths are preventable when appropriate and timely care is sought. In Ethiopia, there is lack of evidence on the type and contribution of delays in treatment seeking to neonatal deaths. METHODS: A community based social autopsy (SA) of 39 neonatal deaths was conducted from March 16 to 24, 2016 in Dabat Health and Demographic Surveillance System (HDSS) in northwest Ethiopia...
December 28, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/29242645/retinal-angiogenesis-regulates-astrocytic-differentiation-in-neonatal-mouse-retinas-by-oxygen-dependent-mechanisms
#4
Li-Juan Duan, Sarah J Pan, Thomas N Sato, Guo-Hua Fong
In mice, retinal vascular and astrocyte networks begin to develop at birth, expanding radially from the optic nerve head (ONH) towards the retinal periphery. The retinal vasculature grows towards the periphery ahead of differentiated astrocytes, but behind astrocytic progenitor cells (APCs) and immature astrocytes. Endothelial cell specific Vegfr-2 disruption in newborn mice not only blocked retinal vascular development but also suppressed astrocytic differentiation, reducing the abundance of differentiated astrocytes while causing the accumulation of precursors...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29208666/epidemiology-of-uk-neonatal-infections-the-neonin-infection-surveillance-network
#5
Benjamin Cailes, Christina Kortsalioudaki, Jim Buttery, Santosh Pattnayak, Anne Greenough, Jean Matthes, Alison Bedford Russell, Nigel Kennea, Paul T Heath
OBJECTIVE: To describe the epidemiology of neonatal infection over the past decade in UK neonatal units. DESIGN: Retrospective analysis of prospectively collected infection surveillance network data from 2005 to 2014. SETTING: 30 neonatal units in the UK. PATIENTS: Newborns on participating neonatal units who had a positive blood, cerebrospinal fluid or urine culture and were treated with at least 5 days of appropriate antibiotics...
December 5, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29202729/changes-in-prevalence-and-perinatal-outcomes-of-congenital-hydrocephalus-among-chinese-newborns-a-retrospective-analysis-based-on-the-hospital-based-birth-defects-surveillance-system
#6
Ling Yi, Chaomin Wan, Changfei Deng, Xiaohong Li, Kui Deng, Yi Mu, Jun Zhu, Qi Li, Yanping Wang, Li Dai
BACKGROUND: Little is known about the epidemiology of congenital hydrocephalus (CH) in China. This study aimed to depict recent changes in CH prevalence and perinatal outcomes of the affected newborns. METHODS: Data were obtained from the Chinese Birth Defects Monitoring Network (CBDMN), which collects demographic information on all newborns above 28 weeks of gestation, and clinical information on neonates with congenital anomalies. CH cases delivered during 2005-2012 were analyzed...
December 4, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29183399/evaluating-progestogens-for-prevention-of-preterm-birth-international-collaborative-epppic-individual-participant-data-ipd-meta-analysis-protocol
#7
Lesley A Stewart, Mark Simmonds, Lelia Duley, Kristina Charlotte Dietz, Melissa Harden, Alex Hodkinson, Alexis Llewellyn, Sahar Sharif, Ruth Walker, Kath Wright
BACKGROUND: Preterm birth is the most common cause of death and harm to newborn babies. Babies that are born early may have difficulties at birth and experience health problems during early childhood. Despite extensive study, there is still uncertainty about the effectiveness of progestogen (medications that are similar to the natural hormone progesterone) in preventing or delaying preterm birth, and in improving birth outcomes. The Evaluating Progestogen for Prevention of Preterm birth International Collaborative (EPPPIC) project aims to reduce uncertainty about the specific conditions in which progestogen may (or may not) be effective in preventing or delaying preterm birth and improving birth outcomes...
November 28, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29183229/prevalence-of-sickle-cell-disease-among-grenadian-newborns
#8
Magdalene Antoine, Ketty Lee, Tyhiesia Donald, Yonni Belfon, Ali Drigo, Sharon Polson, Francis Martin, George Mitchell, Maryse Etienne-Julan, Marie-Dominique Hardy-Dessources
Objective To establish the birth prevalence of sickle cell disease in Grenada, with a view to assess the requirement for a population-based neonatal screening programme. Methods A two-year pilot neonatal screening programme, involving the Ministry of Health of Grenada, the Sickle Cell Association of Grenada, and the diagnostic laboratory of hemoglobinopathies of the University Hospital of Guadeloupe, was implemented in 2014-2015 under the auspices of the Caribbean Network of Researchers on Sickle Cell Disease and Thalassemia...
January 1, 2017: Journal of Medical Screening
https://www.readbyqxmd.com/read/29106509/fmri-based-neuronal-response-to-new-odorants-in-the-newborn-brain
#9
Alexandra Adam-Darque, Frédéric Grouiller, Lana Vasung, Russia Ha-Vinh Leuchter, Philippe Pollien, François Lazeyras, Petra S Hüppi
The sense of smell is one of the oldest and the most primitive senses mammals possess, it helps to evaluate the surrounding environment. From birth, smell is an important sensory modality, highly relevant for neonatal behavioral adaptation. Even though human newborns seem to be able to perceive and react to olfactory stimuli, there is still a lack of knowledge about the ontogeny of smell and the underlying central processing involved in odor perception in newborns. Brain networks involved in chemosensory perception of odorants are well described in adults, however in newborns there is no evidence that central olfaction is functional given the largely unmyelinated neonatal central nervous system...
July 6, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29074716/antimicrobial-resistance-in-uk-neonatal-units-neonin-infection-surveillance-network
#10
Benjamin Cailes, Christina Kortsalioudaki, Jim Buttery, Santosh Pattnayak, Anne Greenough, Jean Matthes, Alison Bedford Russell, Nigel Kennea, Paul T Heath
OBJECTIVE: To define the susceptibilities of the common causative pathogens of neonatal sepsis in the UK. DESIGN: Retrospective analysis of the prospectively collected neonIN infection surveillance network data between 2005 and 2014. SETTING: 30 neonatal units in the UK. PATIENTS: Newborns admitted to participating neonatal units who return a positive blood, cerebrospinal fluid or urine culture and are treated with at least 5 days of appropriate antibiotics...
October 26, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29069076/childhood-stunting-in-relation-to-the-pre-and-postnatal-environment-during-the-first-2-years-of-life-the-mal-ed-longitudinal-birth-cohort-study
#11
(no author information available yet)
BACKGROUND: Stunting is the most prevalent manifestation of childhood malnutrition. To characterize factors that contribute to stunting in resource-poor settings, we studied a priori selected biological and social factors collected longitudinally in a cohort of newborns. METHODS AND FINDINGS: We enrolled 1,868 children across 7 resource-poor settings in Bangladesh, Brazil, India, Nepal, Peru, South Africa, and Tanzania shortly after birth and followed them for 24 months between 2 November 2009 and 28 February 2014...
October 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29067428/effect-of-therapeutic-hypothermia-initiated-after-6-hours-of-age-on-death-or-disability-among-newborns-with-hypoxic-ischemic-encephalopathy-a-randomized-clinical-trial
#12
RANDOMIZED CONTROLLED TRIAL
Abbot R Laptook, Seetha Shankaran, Jon E Tyson, Breda Munoz, Edward F Bell, Ronald N Goldberg, Nehal A Parikh, Namasivayam Ambalavanan, Claudia Pedroza, Athina Pappas, Abhik Das, Aasma S Chaudhary, Richard A Ehrenkranz, Angelita M Hensman, Krisa P Van Meurs, Lina F Chalak, Shannon E G Hamrick, Gregory M Sokol, Michele C Walsh, Brenda B Poindexter, Roger G Faix, Kristi L Watterberg, Ivan D Frantz, Ronnie Guillet, Uday Devaskar, William E Truog, Valerie Y Chock, Myra H Wyckoff, Elisabeth C McGowan, David P Carlton, Heidi M Harmon, Jane E Brumbaugh, C Michael Cotten, Pablo J Sánchez, Anna Maria Hibbs, Rosemary D Higgins
Importance: Hypothermia initiated at less than 6 hours after birth reduces death or disability for infants with hypoxic-ischemic encephalopathy at 36 weeks' or later gestation. To our knowledge, hypothermia trials have not been performed in infants presenting after 6 hours. Objective: To estimate the probability that hypothermia initiated at 6 to 24 hours after birth reduces the risk of death or disability at 18 months among infants with hypoxic-ischemic encephalopathy...
October 24, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29058455/newborn-neurons-are-damaged-in-vitro-by-a-low-concentration-of-silver-nanoparticles-through-the-inflammatory-oxidative-stress-pathway
#13
Xiaoyuan Guo, Guilong Zhang, Lukui Chen, Ahsan Ali Khan, Bin Gu, Bingqian Li
With increasing applications of nanomaterials, including silver nanoparticles (AgNPs), unknown potential risks are present against humans and the environment, especially to the fetus and neonates, which are more sensitive to the cytotoxicity of such agents. This study focused on the effects of AgNP exposure on newborn neurons differentiated from neural stem cells (NSCs) in vitro. We isolated NSCs from fetal rat hippocampus and incubated them in neural differentiation medium for 3-7 days to form newborn neurons and networks...
December 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/29034164/aberrant-brain-functional-connectivity-in-newborns-with-congenital-heart-disease-before-cardiac-surgery
#14
Josepheen De Asis-Cruz, Mary T Donofrio, Gilbert Vezina, Catherine Limperopoulos
Newborns with congenital heart disease (CHD) requiring open heart surgery are at increased risk for neurodevelopmental disabilities. Recent quantitative MRI studies have reported disrupted growth, microstructure, and metabolism in fetuses and newborns with complex CHD. To date, no study has examined whether functional brain connectivity is altered in this high-risk population after birth, before surgery. Our objective was to compare whole-brain functional connectivity of resting state networks in healthy, term newborns (n = 82) and in term neonates with CHD before surgery (n = 30) using graph theory and network-based statistics...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28981766/overview-methods-and-results-of-multi-country-community-based-maternal-and-newborn-care-economic-analysis
#15
Emmanuelle Daviaud, Helen Owen, Catherine Pitt, Kate Kerber, Fiorella Bianchi Jassir, Diana Barger, Fatuma Manzi, Elizabeth Ekipara-Kiracho, Giulia Greco, Peter Waiswa, Joy E Lawn
Home visits for pregnancy and postnatal care were endorsed by the WHO and partners as a complementary strategy to facility-based care to reduce newborn and maternal mortality. This article aims to synthesise findings and implications from the economic analyses of community-based maternal and newborn care (CBMNC) evaluations in seven countries. The evaluations included five cluster randomized trials (Ethiopia, Ghana, South Africa, Tanzania, Uganda) and programmatic before/after assessments (Bolivia, Malawi)...
October 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28971246/transfer-of-maternal-immunity-and-programming-of-the-newborn-immune-system
#16
REVIEW
Madeleine F Jennewein, Bahaa Abu-Raya, Yiwei Jiang, Galit Alter, Arnaud Marchant
As placental mammals, the pregnant women and the fetus have intense and prolonged interactions during gestation. There is increasing evidence that multiple molecular as well as cellular components originating in pregnant women are transferred to the fetus. The transfer of maternal antibodies has long been recognized as a central component of newborn immunity against pathogens. More recent studies indicate that inflammatory mediators, micronutrients, microbial products and maternal cells are transferred in utero and influence the fetal immune system...
November 2017: Seminars in Immunopathology
https://www.readbyqxmd.com/read/28937832/aberrant-plasticity-in-the-hippocampus-after-neonatal-seizures
#17
Xiaoqian Zhang, Huiling Qu, Ying Wang, Shanshan Zhao, Ting Xiao, Chuansheng Zhao, Weiyu Teng
Neonatal seizures are the most frequent type of neurological disorder and those newborn babies that experience seizures carry an increased risk of epileptogenesis and other long-term morbidities. The newly generated dentate granule cells (DGCs) integrate functionally into the mature hippocampal network by continuously forming connections with their targets but this process of adult neurogenesis can be influenced by seizures. When compared to adult seizures, neonatal seizures may exert different effects on neurogenesis due to the high resistance of the newborn's neurons to cell death combined with the inherent high sensitivity to seizures in the immature brain...
September 22, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28927277/benchmark-dose-modeling-estimates-of-the-concentrations-of-inorganic-arsenic-that-induce-changes-to-the-neonatal-transcriptome-proteome-and-epigenome-in-a-pregnancy-cohort
#18
Julia E Rager, Scott S Auerbach, Grace A Chappell, Elizabeth Martin, Chad M Thompson, Rebecca C Fry
Prenatal inorganic arsenic (iAs) exposure influences the expression of critical genes and proteins associated with adverse outcomes in newborns, in part through epigenetic mediators. The doses at which these genomic and epigenomic changes occur have yet to be evaluated in the context of dose-response modeling. The goal of the present study was to estimate iAs doses that correspond to changes in transcriptomic, proteomic, epigenomic, and integrated multi-omic signatures in human cord blood through benchmark dose (BMD) modeling...
October 16, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28799450/comparing-performance-of-methods-used-to-identify-pregnant-women-pregnancy-outcomes-and-child-mortality-in-the-iganga-mayuge-health-and-demographic-surveillance-site-uganda
#19
Daniel Kadobera, Peter Waiswa, Stefan Peterson, Hannah Blencowe, Joy Lawn, Kate Kerber, Nazarius Mbona Tumwesigye
BACKGROUND: In most low and middle-income countries vital events registration for births and child deaths is poor, with reporting of pregnancy outcomes highly inadequate or non-existent. Health and Demographic Surveillance System (HDSS) sites and periodic population-based household-level surveys can be used to identify pregnancies and retrospectively capture pregnancy outcomes to provide data for decision making. However, little is known about the performance of different methods in identifying pregnancy and pregnancy outcomes, yet this is critical in assessing improvements in reducing maternal and newborn mortality and stillbirths...
2017: Global Health Action
https://www.readbyqxmd.com/read/28782073/predictors-of-treatment-warranted-retinopathy-of-prematurity-in-the-sundrop-cohort-influence-of-photographic-features
#20
Cassie A Ludwig, Margaret A Greven, Darius M Moshfeghi
PURPOSE: The Stanford University Network for the Diagnosis of Retinopathy of Prematurity (SUNDROP) initiative-an ongoing telemedicine-based initiative for in-hospital screening of high-risk infants for treatment-warranted ROP (TW-ROP)-has been shown to be a safe, reliable, and cost-effective supplement to the efforts of ROP specialists. We utilized data collected in the SUNDROP initiative to determine demographic (birth weight, sex, multiplicity), weight gain, and ocular imaging (media haze, peripapillary atrophy, fundus pigmentation) predictors of TW-ROP...
October 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
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