Yuanyuan Wei, Yimeng Fan, Sijuan Huang, Jianyu Lv, Yannan Zhang, Zhihui Hao
BACKGROUND: Diarrhea-predominant irritable bowel syndrome (IBS-D) is a common functional gastrointestinal disease. Besides, baizhu shaoyao decoction (BSD) is an effective treatment for IBS-D; however, its mechanism of action remains unclear. PURPOSE: This study aims to assess the ability of BSD to therapy IBS-D and to elucidate the underlying mechanism. METHODS: First, comprehensive analyses, including ADME (absorption, distribution, metabolism, excretion) screening, Venn analysis, Gene Ontology (GO) analysis, and network construction, were performed to characterize IBS-D-related pathways and explore the synergistic effects of BSD active compounds...
October 26, 2023: Phytomedicine