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https://www.readbyqxmd.com/read/28160323/recipient-vessels-for-microsurgical-flaps-to-the-abdomen-a-systematic-review
#1
REVIEW
Raffi Gurunluoglu, Michael J Rosen
BACKGROUND: Large soft tissue defects of the abdominal wall resulting from various reasons may require free tissue transfer. METHODS: A literature search of PubMed and Cochrane electronic databases was conducted to identify articles involving abdominal wall reconstruction (AWR) with microsurgical flap. Number of cases, etiology, and reconstruction site, type of microsurgical flap and recipient vessels were analyzed. RESULTS: Thirty-eight articles published between 1983 and 2016 reported on 149 patients undergoing free flap AWR...
February 4, 2017: Microsurgery
https://www.readbyqxmd.com/read/28110086/different-mechanisms-in-learning-different-second-languages-evidence-from-english-speakers-learning-chinese-and-spanish
#2
Fan Cao, Bethany L Sussman, Valeria Rios, Xin Yan, Zhao Wang, Gregory J Spray, Ryan M Mack
Word reading has been found to be associated with different neural networks in different languages, with greater involvement of the lexical pathway for opaque languages and greater invovlement of the sub-lexical pathway for transparent langauges. However, we do not know whether this language divergence can be demonstrated in second langauge learners, how learner's metalinguistic ability would modulate the langauge divergence, or whether learning method would interact with the language divergence. In this study, we attempted to answer these questions by comparing brain activations of Chinese and Spanish word reading in native English-speaking adults who learned Chinese and Spanish over a 2 week period under three learning conditions: phonological, handwriting, and passive viewing...
January 19, 2017: NeuroImage
https://www.readbyqxmd.com/read/28102927/complex-abdominal-wall-reconstruction-in-the-setting-of-active-infection-and-contamination-a-systematic-review-of-hernia-and-fistula-recurrence-rates
#3
REVIEW
Jonathan D Hodgkinson, Yasuko Maeda, Cosimo A Leo, Janindra Warusavitarne, Carolynne J Vaizey
INTRODUCTION: Minimal evidence exists to guide the surgeon on the risk of complications when performing abdominal wall reconstruction (AWR) in the presence of active infection, contamination or enterocutaneous fistula. This study aims to establish the outcomes of contaminated complex AWR. METHODS: Analysis was conducted according to PRISMA guidelines. Systematic search of the MEDLINE, EMBASE and Pubmed databases was performed. Studies reporting exclusively on single-staged repair of contaminated complex AWR were included...
January 19, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28045949/influence-of-volatile-anesthesia-on-the-release-of-glutamate-and-other-amino-acids-in-the-nucleus-accumbens-in-a-rat-model-of-alcohol-withdrawal-a-pilot-study
#4
Thomas Seidemann, Claudia Spies, Rudolf Morgenstern, Klaus-Dieter Wernecke, Nicolai Netzhammer
BACKGROUND: Alcohol withdrawal syndrome is a potentially life-threatening condition, which can occur when patients with alcohol use disorders undergo general anesthesia. Excitatory amino acids, such as glutamate, act as neurotransmitters and are known to play a key role in alcohol withdrawal syndrome. To understand this process better, we investigated the influence of isoflurane, sevoflurane, and desflurane anesthesia on the profile of excitatory and inhibitory amino acids in the nucleus accumbens (NAcc) of alcohol-withdrawn rats (AWR)...
2017: PloS One
https://www.readbyqxmd.com/read/27993696/long-term-outcomes-after-abdominal-wall-reconstruction-with-acellular-dermal-matrix
#5
Patrick B Garvey, Salvatore A Giordano, Donald P Baumann, Jun Liu, Charles E Butler
BACKGROUND: Long-term outcomes data for hernia recurrence rates after abdominal wall reconstruction (AWR) with acellular dermal matrix (ADM) are lacking. The aim of this study was to assess the long-term durability of AWR using ADM. STUDY DESIGN: We studied patients who underwent AWR with ADM at a single center in 2005 to 2015 with a minimum follow-up of 36 months. Hernia recurrence was the primary end point and surgical site occurrence (SSO) was a secondary end point...
December 18, 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27965133/abdominal-wall-reconstruction-with-concomitant-ostomy-associated-hernia-repair-outcomes-and-propensity-score-analysis
#6
Alexander F Mericli, Patrick B Garvey, Salvatore Giordano, Jun Liu, Donald P Baumann, Charles E Butler
BACKGROUND: The optimal strategy for abdominal wall reconstruction in the presence of a stomal-site hernia is unclear. We hypothesized that the rate of ventral hernia recurrence in patients undergoing a combined ventral hernia repair and stomal-site herniorraphy would not differ clinically from the ventral hernia recurrence rate in patients undergoing an isolated ventral hernia repair. We also hypothesized that bridged ventral hernia repairs result in worse outcomes compared to reinforced repairs regardless of stomal hernia...
December 10, 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27939763/advanced-age-does-not-affect-abdominal-wall-reconstruction-outcomes-using-acellular-dermal-matrix-a-comparative-study-using-propensity-score-analysis
#7
Salvatore Giordano, Mark Schaverien, Patrick B Garvey, Donald P Baumann, Jun Liu, Charles E Butler
BACKGROUND: We hypothesized that elderly patients (≥65 years) experience worse outcomes following abdominal wall reconstruction (AWR) for hernia or oncologic resection. METHODS: We included all consecutive patients who underwent complex AWR using acellular dermal matrix (ADM) between 2005 and 2015. Propensity score analysis was performed for risk adjustment in multivariable analysis and for one-to-one matching. The primary outcome was hernia recurrence; the secondary outcomes included surgical site occurrence (SSO) and bulging...
November 30, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27800587/evaluation-of-antibiotic-pressurized-pulse-lavage-for-contaminated-retromuscular-abdominal-wall-reconstruction
#8
Arnab Majumder, Heidi J Miller, Parita Patel, Yuhsin V Wu, Heidi L Elliott, Yuri W Novitsky
BACKGROUND: Despite patient risk factors such as diabetes and obesity, contamination during surgery remains a significant cause of infections and subsequent wound morbidity. Pressurized pulse lavage (PPL) has been utilized as a method to reduce bacterial bioburden with promising results in many fields. Although existing methods of lavage have been utilized during abdominal operations, no studies have examined the use of PPL during complex hernia repair. METHODS: Patients undergoing abdominal wall reconstruction (AWR) in clean-contaminated or contaminated fields with antibiotic PPL, from January 2012 to May 2013, were prospectively evaluated...
October 31, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27781340/p2x3-receptor-mediated-visceral-hyperalgesia-and-neuronal-sensitization-following-exposure-to-ptsd-like-stress-in-the-dorsal-root-ganglia-of-rats
#9
Y-Q He, X-Q Lang, L Lin, L Ji, X-Y Yuan, Q Chen, Y-M Ran, H-S Chen, L Li, J-M Wang, Z-G Wang, H Gregersen, D-W Zou, H-P Liang, M Yang
BACKGROUND: Patients with posttraumatic stress disorder (PTSD) often share co-morbidity with chronic pain conditions. Recent studies suggest a role of P2X3 receptors and ATP signaling in pain conditions. However, the underlying mechanisms of visceral hyperalgesia following exposure to PTSD-like stress conditions remain unclarified. METHODS: The behavior and hormones relevant for PTSD were studied. Visceromotor responses (VMR) and the abdominal withdrawal reflexes (AWR) to colorectal distention (CRD) were recorded to determine P2X3-receptor-mediated alteration of hyperalgesia following single-prolonged stress (SPS) exposure...
October 25, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27754767/synthetic-versus-biologic-mesh-in-single-stage-repair-of-complex-abdominal-wall-defects-in-a-contaminated-field
#10
Jad Chamieh, Wen Hui Tan, Ricardo Ramirez, Eden Nohra, Chukwuma Apakama, William Symons
BACKGROUND: Synthetic meshes have been used with varying rates of success in a contaminated setting, although their use is not widely accepted because of concerns for infection. A biologic mesh (BM) is assumed to be more resistant to infection than a synthetic mesh; however, sparse clinical data support this theory. The hypothesis for this study: Uncoated polypropylene synthetic mesh (USM) can be used to obtain a durable repair in the setting of a contaminated abdominal wall reconstruction (AWR) in a single-stage procedure with comparable infectious outcomes to a biologic mesh repair...
February 2017: Surgical Infections
https://www.readbyqxmd.com/read/27738447/comparison-of-electroacupuncture-and-moxibustion-for-relieving-visceral-hypersensitivity-in-rats-with-constipation-predominant-irritable-bowel-syndrome
#11
Ji-Meng Zhao, Liu Chen, Ci-Li Zhou, Yin Shi, Yu-Wei Li, Hai-Xia Shang, Lu-Yi Wu, Chun-Hui Bao, Chuan-Zi Dou, Huan-Gan Wu
Aim. To compare whether there is different effect between electroacupuncture (EA) and moxibustion (Mox) on visceral hypersensitivity (their analgesic effects) in constipation-predominant irritable bowel syndrome (C-IBS). Methods. EA at 1 mA and 3 mA and Mox at 43°C and 46°C were applied to the Shangjuxu (ST37, bilateral) acupoint in rats with C-IBS and normal rats. An abdominal withdrawal reflex (AWR) score was used to assess visceral hypersensitivity. Toluidine blue staining was used to assess mast cell (MC) activity in colon of rats...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27712718/a-comprehensive-algorithm-for-approval-of-health-technologies-with-without-or-only-in-research-the-key-principles-for-informing-coverage-decisions
#12
Karl Claxton, Stephen Palmer, Louise Longworth, Laura Bojke, Susan Griffin, Marta Soares, Eldon Spackman, Claire Rothery
BACKGROUND: The value of evidence about the performance of a technology and the value of access to a technology are central to policy decisions regarding coverage with, without, or only in research and managed entry (or risk-sharing) agreements. OBJECTIVES: We aim to outline the key principles of what assessments are needed to inform "only in research" (OIR) or "approval with research" (AWR) recommendations, in addition to approval or rejection. METHODS: We developed a comprehensive algorithm to inform the sequence of assessments and judgments that lead to different types of guidance: OIR, AWR, Approve, or Reject...
September 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27696169/prior-radiotherapy-does-not-affect-abdominal-wall-reconstruction-outcomes-evidence-from-propensity-score-analysis
#13
Salvatore Giordano, Patrick B Garvey, Donald P Baumann, Jun Liu, Charles E Butler
BACKGROUND: Prior abdominal wall radiotherapy (XRT) adversely affects wound healing, but data are limited on how prior XRT may affect abdominal wall reconstruction (AWR) outcomes. The purpose of this study was to determine whether prior abdominal wall radiotherapy is associated with a higher incidence of complications following AWR for a hernia or oncologic resection defect. METHODS: We performed a retrospective study of consecutive patients who underwent complex AWR using acellular dermal matrix (ADM) at a single center...
September 30, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27686629/a-high-throughput-arbitrary-waveform-mpi-spectrometer-and-relaxometer-for-comprehensive-magnetic-particle-optimization-and-characterization
#14
Zhi Wei Tay, Patrick W Goodwill, Daniel W Hensley, Laura A Taylor, Bo Zheng, Steven M Conolly
Magnetic Particle Imaging (MPI) is a promising new tracer modality with zero attenuation deep in tissue, high contrast and sensitivity, and an excellent safety profile. However, the spatial resolution of MPI is limited to around 1 mm currently and urgently needs to be improved for clinical applications such as angiography and brain perfusion. Although MPI resolution is highly dependent on tracer characteristics and the drive waveforms, optimization is limited to a small subset of possible excitation strategies by current MPI hardware that only does sinusoidal drive waveforms at very few frequencies...
September 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27647937/serelaxin-improves-the-therapeutic-efficacy-of-rxfp1-expressing-human-amnion-epithelial-cells-in-experimental-allergic-airways-disease
#15
Simon G Royce, Anna M Tominaga, Matthew Shen, Krupesh P Patel, Brooke M Huuskes, Rebecca Lim, Sharon D Ricardo, Chrishan S Samuel
Current asthma therapies primarily target airway inflammation (AI) and suppress episodes of airway hyperresponsiveness (AHR) but fail to treat airway remodelling (AWR), which can develop independently of AI and contribute to irreversible airway obstruction. This study compared the anti-remodelling and therapeutic efficacy of human bone marrow-derived mesenchymal stem cells (MSCs) to that of human amnion epithelial stem cells (AECs) in the setting of chronic allergic airways disease (AAD), in the absence or presence of an anti-fibrotic (serelaxin; RLX)...
September 19, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27477797/preoperative-steroid-in-abdominal-wall-reconstruction-protocol-for-a-randomised-trial
#16
RANDOMIZED CONTROLLED TRIAL
Kristian Kiim Jensen, Tina Lee Brøndum, Bo Belhage, Margaret Hensler, Regnar Bøge Arnesen, Henrik Kehlet, Lars Nannestad Jørgensen
INTRODUCTION: Preoperative administration of high-dose glucocorticoid leads to improved recovery and decreased length of stay after abdominal surgery. Even so, studies on administration of glucocorticoids for patients undergoing abdominal wall reconstruction (AWR) for giant ventral hernia repair are lacking, perhaps due to a fear of impaired wound healing. We hypothesised that patients undergoing AWR would benefit from preoperative glucocorticoids and aimed at examining this in a randomised controlled trial...
August 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27421887/early-clinical-outcomes-of-a-novel-antibiotic-coated-non-crosslinked-porcine-acellular-dermal-graft-after-complex-abdominal-wall-reconstruction
#17
Erin H Baker, Darren Lepere, Megan P Lundgren, Patrick J Greaney, David A Ehrlich, Steven E Copit, Allison L Murphree, Anthony J Canfield, Glenn Parker, David A Iannitti
BACKGROUND: Non-crosslinked porcine acellular dermal grafts (NCPADG) are currently the mainstay biomaterial for abdominal wall reconstruction (AWR) in complex hernia patients. We report early clinical outcomes using a novel rifampin/minocycline-coated NCPADG for AWR. STUDY DESIGN: A multi-institutional retrospective review was performed of patients who underwent ventral hernia repair using XenMatrix AB Surgical Graft (CR Bard, Inc [Davol]). Patient demographics, hernia and procedure characteristics, and surgical site occurrences/postoperative complications were reviewed up to 6 months after AWR...
October 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27380730/nesfatin-1-nucb2-in-the-amygdala-influences-visceral-sensitivity-via-glucocorticoid-and-mineralocorticoid-receptors-in-male-maternal-separation-rats
#18
X-P Zhou, J Sha, L Huang, T-N Li, R-R Zhang, M-D Tang, L Lin, X-L Li
BACKGROUND: Nesfatin-1, a recently identified satiety molecule derived from nucleobindin 2 (NUCB2), is associated with visceral hypersensitivity in rats and is expressed in the amygdala. We tested the hypothesis that nesfatin-1 expression in the amygdala is involved in the pathogenesis of irritable bowel syndrome (IBS) visceral hypersensitivity. METHODS: An animal model of IBS-like visceral hypersensitivity was established using maternal separation (MS) during postnatal days 2-16...
October 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27370939/electroacupuncture-analgesia-with-different-frequencies-is-mediated-via-different-opioid-pathways-in-acute-visceral-hyperalgesia-rats
#19
Debo Qi, Shuqin Wu, Yuhua Zhang, Weimin Li
AIMS: To investigate the efficacy of electroacupuncture (EA) alleviation of acute visceral hyperalgesia, the frequency dependence of this efficacy, and the difference in endogenous opioid pathways as underlying mechanism explaining the frequency dependence. MAIN METHODS: A visceral hyperalgesia model was established by colorectal instillation of 2% acetic acid (AA) in adult rats. EA treatment at 2Hz, 100Hz, 2/100Hz and sham EA were performed at two bilateral acupoints, ST-36 and ST-37, in the hind-limbs...
September 1, 2016: Life Sciences
https://www.readbyqxmd.com/read/27356126/colonic-mucosal-n-methyl-d-aspartate-receptor-mediated-visceral-hypersensitivity-in-a-mouse-model-of-irritable-bowel-syndrome
#20
Qing Qing Qi, Fei Xue Chen, Dong Yan Zhao, Li Xiang Li, Peng Wang, Yan Qing Li, Xiu Li Zuo
OBJECTIVE: The aim of this study was to investigate whether colonic mucosal N-methyl-D-aspartate receptor (NMDAR) participates in visceral hypersensitivity in irritable bowel syndrome (IBS). METHODS: C57BL/6 mice were administered intrarectally with trinitrobenzenesulfonic acid (TNBS) for the establishment of an IBS-like visceral hypersensitivity model. Those received an equivalent volume of 50% ethanol were regarded as the controls. Abdominal withdrawal reflex (AWR) scores in response to colorectal distention (CRD) were used to assess visceral sensitivity...
July 2016: Journal of Digestive Diseases
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