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Glioma AND iron

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https://www.readbyqxmd.com/read/29730475/six-transmembrane-epithelial-antigen-of-prostate-3-predicts-poor-prognosis-and-promotes-glioblastoma-growth-and-invasion
#1
Mingzhi Han, Ran Xu, Shuai Wang, Ning Yang, Shilei Ni, Qing Zhang, Yangyang Xu, Xin Zhang, Chao Zhang, Yuzhen Wei, Jianxiong Ji, Bin Huang, Di Zhang, Anjing Chen, Wenjie Li, Rolf Bjerkvig, Xingang Li, Jian Wang
Recent evidence suggests that dysregulation of iron regulatory factors may play essential roles in cancer pathophysiology. Six-transmembrane epithelial antigen of prostate 3 (STEAP3) is a metalloreductase, which is vital for cellular iron uptake and homeostasis. However, the clinical significance and function of STEAP3 in the development of human gliomas remain unclear. Through analysis of publicly available databases, we found that STEAP3 was highly expressed in malignant gliomas, especially in the mesenchymal glioma molecular subtype and isocitrate dehydrogenase 1/2 (IDH1/2) wild-type gliomas...
May 3, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29702192/pseudolaric-acid-b-triggers-ferroptosis-in-glioma-cells-via-activation-of-nox4-and-inhibition-of-xct
#2
Zongqi Wang, Ye Ding, Xuanzhong Wang, Shan Lu, Chongcheng Wang, Chuan He, Lei Wang, Meihua Piao, Guangfan Chi, Yinan Luo, Pengfei Ge
Ferroptosis is a form of programmed cell death decided by iron-dependent lipid peroxidation, but its role in glioma cell death remains unclear. In this study, we found Pseudolaric acid B (PAB) inhibited the viabilities of glioma cells in vitro and in vivo, which was accompanied by abnormal increases of intracellular ferrous iron, H2 O2 and lipid peroxidation, as well as depletion of GSH and cysteine. In vitro studies revealed that the lipid peroxidation and the cell death caused by PAB were both inhibited by iron chelator deferoxamine, but exacerbated by supplement of ferric ammonium citrate...
April 24, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29599614/interaction-of-poly-l-lysine-coating-and-heparan-sulfate-proteoglycan-on-magnetic-nanoparticle-uptake-by-tumor-cells
#3
Wei Xiong Siow, Yi-Ting Chang, Michal Babič, Yi-Ching Lu, Daniel Horák, Yunn-Hwa Ma
Background: Poly-l-lysine (PLL) enhances nanoparticle (NP) uptake, but the molecular mechanism remains unresolved. We asked whether PLL may interact with negatively charged glycoconjugates on the cell surface and facilitate uptake of magnetic NPs (MNPs) by tumor cells. Methods: PLL-coated MNPs (PLL-MNPs) with positive and negative ζ-potential were prepared and characterized. Confocal and transmission electron microscopy was used to analyze cellular internalization of MNPs...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29559776/targeting-experimental-orthotopic-glioblastoma-with-chitosan-based-superparamagnetic-iron-oxide-nanoparticles-cs-dx-spions
#4
Maxim Shevtsov, Boris Nikolaev, Yaroslav Marchenko, Ludmila Yakovleva, Nikita Skvortsov, Anton Mazur, Peter Tolstoy, Vyacheslav Ryzhov, Gabriele Multhoff
Background: Glioblastoma is the most devastating primary brain tumor of the central nervous system in adults. Magnetic nanocarriers may help not only for a targeted delivery of chemotherapeutic agents into the tumor site but also provide contrast enhancing properties for diagnostics using magnetic resonance imaging (MRI). Methods: Synthesized hybrid chitosan-dextran superparamagnetic nanoparticles (CS-DX-SPIONs) were characterized using transmission electron microscopy (TEM) and relaxometry studies...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29438105/magnetic-resonance-and-photoacoustic-imaging-of-brain-tumor-mediated-by-mesenchymal-stem-cell-labeled-with-multifunctional-nanoparticle-introduced-via-carotid-artery-injection
#5
Yang Qiao, Joy Gumin, Christopher J MacLellan, Feng Gao, Richard Bouchard, Frederick F Lang, R Jason Stafford, Marites P Melancon
OBJECTIVE: To evaluate the feasibility of visualizing bone marrow-derived human mesenchymal stem cells (MSCs) labeled with a gold-coated magnetic resonance (MR)-active multifunctional nanoparticle and injected via the carotid artery for assessing the extent of MSC homing in glioma-bearing mice. MATERIALS AND METHODS: Nanoparticles containing superparamagnetic iron oxide coated with gold (SPIO@Au) with a diameter of ∼82 nm and maximum absorbance in the near infrared region were synthesized...
April 20, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29350498/glioma-targeted-delivery-of-a-theranostic-liposome-integrated-with-quantum-dots-superparamagnetic-iron-oxide-and-cilengitide-for-dual-imaging-guiding-cancer-surgery
#6
He-Lin Xu, Jing-Jing Yang, De-Li ZhuGe, Meng-Ting Lin, Qun-Yan Zhu, Bing-Hui Jin, Meng-Qi Tong, Bi-Xin Shen, Jian Xiao, Ying-Zheng Zhao
Herein, a theranostic liposome (QSC-Lip) integrated with superparamagnetic iron oxide nanoparticles (SPIONs) and quantum dots (QDs) and cilengitide (CGT) into one platform is constructed to target glioma under magnetic targeting (MT) for guiding surgical resection of glioma. Transmission electron microscopy and X-ray photoelectron spectroscopy confirm the complete coencapsulation of SPIONs and QDs in liposome. Besides, CGT is also effectively encapsulated into the liposome with an encapsulation efficiency of ∼88...
January 19, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29350351/convection-enhanced-delivery-of-cetuximab-conjugated-iron-oxide-nanoparticles-for-treatment-of-spontaneous-canine-intracranial-gliomas
#7
A Courtenay Freeman, Simon R Platt, Shannon Holmes, M Kent, Kelsey Robinson, Elizabeth Howerth, Joe Eagleson, Alexandros Bouras, Milota Kaluzova, Constantinos G Hadjipanayis
Cetuximab conjugated iron-oxide nanoparticles (cetuximab-IONPs) have shown both in-vitro and in-vivo anti-tumor efficacy against gliomas. The purpose of this pilot study was to evaluate the safety and potential efficacy of cetuximab-IONPs for treatment of spontaneously occurring intracranial gliomas in canines after convection-enhanced delivery (CED). The use of CED allowed for direct infusion of the cetuximab-IONPs both intratumorally and peritumorally avoiding the blood brain barrier (BBB) and limiting systemic effects...
January 19, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29158849/enhanced-antitumor-efficacy-of-biocompatible-magnetosomes-for-the-magnetic-hyperthermia-treatment-of-glioblastoma
#8
Raphaël Le Fèvre, Mickaël Durand-Dubief, Imène Chebbi, Chalani Mandawala, France Lagroix, Jean-Pierre Valet, Ahmed Idbaih, Clovis Adam, Jean-Yves Delattre, Charlotte Schmitt, Caroline Maake, François Guyot, Edouard Alphandéry
In this study, biologically synthesized iron oxide nanoparticles, called magnetosomes, are made fully biocompatible by removing potentially toxic organic bacterial residues such as endotoxins at magnetosome mineral core surfaces and by coating such surface with poly-L-lysine, leading to magnetosomes-poly-L-lysine (M-PLL). M-PLL antitumor efficacy is compared with that of chemically synthesized iron oxide nanoparticles (IONPs) currently used for magnetic hyperthermia. M-PLL and IONPs are tested for the treatment of glioblastoma, a dreadful cancer, in which intratumor nanoparticle administration is clinically relevant, using a mouse allograft model of murine glioma (GL-261 cell line)...
2017: Theranostics
https://www.readbyqxmd.com/read/29059872/nanoparticle-based-delivery-of-an-anti-proliferative-metal-chelator-to-tumor-cells
#9
Y J Kang, C-F Kuo, S Majd
This paper describes the preparation and characterization of polymeric nanoparticles loaded with a potent anti-tumor metal chelator, Di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT) for delivery to cancer cells. Metal chelators have been increasingly studied for their anti-cancer properties that rely on the high demand of neoplastic cells for iron. Dp44mT has previously shown great antiproliferative characteristics in several cancers including breast cancer and melanoma. To further expand the application of this highly cytotoxic agent for cancer treatment and to enable its specific delivery to malignant cells, here we apply nano-scale particles (NPs) of biodegradable poly(lactic-co-glycolide) (PLGA) for encapsulation of Dp44mT and evaluate its effectiveness in vitro...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28983596/cisd2-promotes-the-proliferation-of-glioma-cells-via-suppressing-beclin%C3%A2-1%C3%A2-mediated-autophagy-and-is-targeted-by-microrna%C3%A2-449a
#10
Ai-Gang Sun, Fan-Guo Meng, Ming-Guang Wang
CDGSH iron sulfur domain 2 (CISD2) has been found to be important in carcinogenesis. However, the role of CISD2 in glioma remains to be elucidated. The present study aimed to investigate the role of CISD2 in glioma using the reverse transcription‑quantitative polymerase chain reaction, western blotting, co‑immunoprecipitation assay, immunofluorescence staining and other methods. The results demonstrated that the mRNA and protein levels of CISD2 were found to be upregulated in glioma tissues, compared with the levels in matched normal tissues...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28841833/lifetime-occupational-exposure-to-metals-and-welding-fumes-and-risk-of-glioma-a-7-country-population-based-case-control-study
#11
Marie-Elise Parent, Michelle C Turner, Jérôme Lavoué, Hugues Richard, Jordi Figuerola, Laurel Kincl, Lesley Richardson, Geza Benke, Maria Blettner, Sarah Fleming, Martine Hours, Daniel Krewski, David McLean, Siegal Sadetzki, Klaus Schlaefer, Brigitte Schlehofer, Joachim Schüz, Jack Siemiatycki, Martie van Tongeren, Elisabeth Cardis
BACKGROUND: Brain tumor etiology is poorly understood. Based on their ability to pass through the blood-brain barrier, it has been hypothesized that exposure to metals may increase the risk of brain cancer. Results from the few epidemiological studies on this issue are limited and inconsistent. METHODS: We investigated the relationship between glioma risk and occupational exposure to five metals - lead, cadmium, nickel, chromium and iron- as well as to welding fumes, using data from the seven-country INTEROCC study...
August 25, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28675230/one-pot-synthesis-of-nanochain-particles-for-targeting-brain-tumors
#12
V S Perera, G Covarrubias, M Lorkowski, P Atukorale, A Rao, S Raghunathan, R Gopalakrishnan, B O Erokwu, Y Liu, D Dixit, S M Brady-Kalnay, D Wilson, C Flask, J Rich, P M Peiris, E Karathanasis
To synthesize multi-component nanochains, we developed a simple 'one-pot' synthesis, which exhibited high yield and consistency. The nanochains particles consist of parent nanospheres chemically linked into a higher-order, chain-like assembly. The one-pot synthesis is based on the addition of two types of parent nanospheres in terms of their surface chemical functionality (e.g., decorated with PEG-NH2 or PEG-COOH). By reacting the two types of parent nanospheres at a specific ratio (∼2 : 1) for a short period of time (∼30 min) under rigorous stirring, nanochains were formed...
July 13, 2017: Nanoscale
https://www.readbyqxmd.com/read/28532109/lactoferrin-modified-graphene-oxide-iron-oxide-nanocomposite-for-glioma-targeted-drug-delivery
#13
Meng-Meng Song, Huai-Liang Xu, Jun-Xing Liang, Hui-Hui Xiang, Rui Liu, Yu-Xian Shen
Targeting delivery of drugs in a specific manner represents a potential powerful technology in gliomas. Herein, we prepared a multifunctional targeted delivery system based on graphene oxide (GO) that contains a molecular bio-targeting ligand and superparamagnetic iron oxide nanoparticles on the surface of GO for magnetic targeting. Superparamagnetic Fe3 O4 nanoparticles was loaded on the surface of GO via chemical precipitation method to form GO@Fe3 O4 nanocomposites. Lactoferrin (Lf), an iron-transporting serum glycoprotein that binds to receptors overexpressed at the surface of glioma cells and vascular endothelial cell of the blood brain barrier, was chosen as the targeted ligand to construct the targeted delivery system Lf@GO@Fe3 O4 through EDC/NHS chemistry...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28408882/targeted-nanotechnology-in-glioblastoma-multiforme
#14
REVIEW
Talita Glaser, Inbo Han, Liquan Wu, Xiang Zeng
Gliomas, and in particular glioblastoma multiforme, are aggressive brain tumors characterized by a poor prognosis and high rates of recurrence. Current treatment strategies are based on open surgery, chemotherapy (temozolomide) and radiotherapy. However, none of these treatments, alone or in combination, are considered effective in managing this devastating disease, resulting in a median survival time of less than 15 months. The efficiency of chemotherapy is mainly compromised by the blood-brain barrier (BBB) that selectively inhibits drugs from infiltrating into the tumor mass...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28356945/evaluation-of-nano-magnetic-fluid-on-malignant-glioma-cells
#15
Hongsheng Xu, Hailiang Zong, Chong Ma, Xing Ming, Ming Shang, Kai Li, Xiaoguang He, Lei Cao
The temperature variation rule of nano-magnetic fluid in the specific magnetic field and the effect on the treatment of malignant glioma were examined. The temperature variation of nano-magnetic fluid in the specific magnetic field was investigated by heating in vitro, and cell morphology was observed through optical microscopy and electron microscopy. MTT detection also was used to detect the effect of Fe3O4 nanometer magnetic fluid hyperthermia (MFH) on the proliferation of human U251 glioma cell line. The Fe3O4 nano MFH experiment was used to detect the inhibition rate of the tumor volume in nude mice with tumors...
February 2017: Oncology Letters
https://www.readbyqxmd.com/read/28281182/evaluation-of-magnetonanoparticles-conjugated-with-new-angiogenesis-peptides-in-intracranial-glioma-tumors-by-mri
#16
Erica Aparecida de Oliveira, Jelena Lazovic, Lea Guo, Horacio Soto, Bluma Linkowski Faintuch, Massoud Akhtari, Whitney Pope
Angiogenesis plays a critical role in progression of malignant gliomas. The development of glioma-specific labeling molecules that can aid detection and visualization of angiogenesis can help surgical planning and improve treatment outcome. The aim of this study was to evaluate if two peptides (GX1 and RGD-GX1) linked to angiogenesis can be used as an MR-imaging markers of angiogenesis. MR imaging was performed in U87 glioblastoma-bearing NOD-SCID mice at different time points between 15 and 120 min post-injection to visualize particle distribution...
September 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28247036/ferritin-heavy-chain-as-a-molecular-imaging-reporter-gene-in-glioma-xenografts
#17
Sen Cheng, Ruifang Mi, Yu Xu, Guishan Jin, Junwen Zhang, Yiqiang Zhou, Zhengguang Chen, Fusheng Liu
PURPOSE: The development of glioma therapy in clinical practice (e.g., gene therapy) calls for efficiently visualizing and tracking glioma cells in vivo. Human ferritin heavy chain is a novel gene reporter in magnetic resonance imaging. This study proposes hFTH as a reporter gene for MR molecular imaging in glioma xenografts. METHODS: Rat C6 glioma cells were infected by packaged lentivirus carrying hFTH and EGFP genes and obtained by fluorescence-activated cell sorting...
June 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28169355/enhancement-of-5-aminolevulinic-acid-based-fluorescence-detection-of-side-population-defined-glioma-stem-cells-by-iron-chelation
#18
Wenqian Wang, Kouichi Tabu, Yuichiro Hagiya, Yuta Sugiyama, Yasuhiro Kokubu, Yoshitaka Murota, Shun-Ichiro Ogura, Tetsuya Taga
Cancer stem cells (CSCs) are dominantly responsible for tumor progression and chemo/radio-resistance, resulting in tumor recurrence. 5-aminolevulinic acid (ALA) is metabolized to fluorescent protoporphyrin IX (PpIX) specifically in tumor cells, and therefore clinically used as a reagent for photodynamic diagnosis (PDD) and therapy (PDT) of cancers including gliomas. However, it remains to be clarified whether this method could be effective for CSC detection. Here, using flow cytometry-based analysis, we show that side population (SP)-defined C6 glioma CSCs (GSCs) displayed much less 5-ALA-derived PpIX fluorescence than non-GSCs...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28024568/study-and-evaluation-of-nucleolin-targeted-delivery-of-magnetic-plga-peg-nanospheres-loaded-with-doxorubicin-to-c6-glioma-cells-compared-with-low-nucleolin-expressing-l929-cells
#19
Jafar Mosafer, Manouchehr Teymouri, Khalil Abnous, Mohsen Tafaghodi, Mohammad Ramezani
Magnetic nanoparticulate systems based on polymeric materials such as poly (lactic-co-glycolic acid) (PLGA1 ) are being studied for their potential applications in targeted therapy and imaging of malignant tumors. In the current study, superparamagnetic iron oxide nanocrystals (SPIONs2 ) and doxorubicin (Dox3 ) were entrapped in the PLGA-based nanoparticles via a modified multiple emulsion solvent evaporation method. Furthermore, SPIO/Dox-NPs4 were conjugated to anti-nucleolin AS1411 aptamer (Apt5 ) and their targeting ability was investigated in high nucleolin-expressing C6 glioma cells compared to low nucleolin-expressing L929 cells...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27959443/an-epirubicin-peptide-conjugate-with-anticancer-activity-is-dependent-upon-the-expression-level-of-the-surface-transferrin-receptor
#20
Jiadan Yang, Qiyu Yang, Lu Xu, Jie Lou, Zhi Dong
Epirubicin (EPI) is one of the most widely used anticarcinogens; however, serious side effects, including cardiomyopathy and congestive heart failure, limit its long‑term administration. To overcome this problem, the HAIYPRH peptide ligand was used with EPI in the synthesis of a HAIYPRH‑EPI conjugate. The anticancer activity and cellular uptake of the conjugate were measured and evaluated. The results of the present study indicated that the cytotoxicity of HAIYPRH‑EPI was correlated with the expression of the cell surface transferrin receptor (TfR)...
January 2017: Molecular Medicine Reports
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