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https://www.readbyqxmd.com/read/28532109/lactoferrin-modified-graphene-oxide-iron-oxide-nanocomposite-for-glioma-targeted-drug-delivery
#1
Meng-Meng Song, Huai-Liang Xu, Jun-Xing Liang, Hui-Hui Xiang, Rui Liu, Yu-Xian Shen
Targeting delivery of drugs in a specific manner represents a potential powerful technology in gliomas. Herein, we prepared a multifunctional targeted delivery system based on graphene oxide (GO) that contains a molecular bio-targeting ligand and superparamagnetic iron oxide nanoparticles on the surface of GO for magnetic targeting. Superparamagnetic Fe3O4 nanoparticles was loaded on the surface of GO via chemical precipitation method to form GO@Fe3O4 nanocomposites. Lactoferrin (Lf), an iron-transporting serum glycoprotein that binds to receptors overexpressed at the surface of glioma cells and vascular endothelial cell of the blood brain barrier, was chosen as the targeted ligand to construct the targeted delivery system Lf@GO@Fe3O4 through EDC/NHS chemistry...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28408882/targeted-nanotechnology-in-glioblastoma-multiforme
#2
REVIEW
Talita Glaser, Inbo Han, Liquan Wu, Xiang Zeng
Gliomas, and in particular glioblastoma multiforme, are aggressive brain tumors characterized by a poor prognosis and high rates of recurrence. Current treatment strategies are based on open surgery, chemotherapy (temozolomide) and radiotherapy. However, none of these treatments, alone or in combination, are considered effective in managing this devastating disease, resulting in a median survival time of less than 15 months. The efficiency of chemotherapy is mainly compromised by the blood-brain barrier (BBB) that selectively inhibits drugs from infiltrating into the tumor mass...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28356945/evaluation-of-nano-magnetic-fluid-on-malignant-glioma-cells
#3
Hongsheng Xu, Hailiang Zong, Chong Ma, Xing Ming, Ming Shang, Kai Li, Xiaoguang He, Lei Cao
The temperature variation rule of nano-magnetic fluid in the specific magnetic field and the effect on the treatment of malignant glioma were examined. The temperature variation of nano-magnetic fluid in the specific magnetic field was investigated by heating in vitro, and cell morphology was observed through optical microscopy and electron microscopy. MTT detection also was used to detect the effect of Fe3O4 nanometer magnetic fluid hyperthermia (MFH) on the proliferation of human U251 glioma cell line. The Fe3O4 nano MFH experiment was used to detect the inhibition rate of the tumor volume in nude mice with tumors...
February 2017: Oncology Letters
https://www.readbyqxmd.com/read/28281182/evaluation-of-magnetonanoparticles-conjugated-with-new-angiogenesis-peptides-in-intracranial-glioma-tumors-by-mri
#4
Erica Aparecida de Oliveira, Jelena Lazovic, Lea Guo, Horacio Soto, Bluma Linkowski Faintuch, Massoud Akhtari, Whitney Pope
Angiogenesis plays a critical role in progression of malignant gliomas. The development of glioma-specific labeling molecules that can aid detection and visualization of angiogenesis can help surgical planning and improve treatment outcome. The aim of this study was to evaluate if two peptides (GX1 and RGD-GX1) linked to angiogenesis can be used as an MR-imaging markers of angiogenesis. MR imaging was performed in U87 glioblastoma-bearing NOD-SCID mice at different time points between 15 and 120 min post-injection to visualize particle distribution...
March 9, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28247036/ferritin-heavy-chain-as-a-molecular-imaging-reporter-gene-in-glioma-xenografts
#5
Sen Cheng, Ruifang Mi, Yu Xu, Guishan Jin, Junwen Zhang, Yiqiang Zhou, Zhengguang Chen, Fusheng Liu
PURPOSE: The development of glioma therapy in clinical practice (e.g., gene therapy) calls for efficiently visualizing and tracking glioma cells in vivo. Human ferritin heavy chain is a novel gene reporter in magnetic resonance imaging. This study proposes hFTH as a reporter gene for MR molecular imaging in glioma xenografts. METHODS: Rat C6 glioma cells were infected by packaged lentivirus carrying hFTH and EGFP genes and obtained by fluorescence-activated cell sorting...
February 28, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28169355/enhancement-of-5-aminolevulinic-acid-based-fluorescence-detection-of-side-population-defined-glioma-stem-cells-by-iron-chelation
#6
Wenqian Wang, Kouichi Tabu, Yuichiro Hagiya, Yuta Sugiyama, Yasuhiro Kokubu, Yoshitaka Murota, Shun-Ichiro Ogura, Tetsuya Taga
Cancer stem cells (CSCs) are dominantly responsible for tumor progression and chemo/radio-resistance, resulting in tumor recurrence. 5-aminolevulinic acid (ALA) is metabolized to fluorescent protoporphyrin IX (PpIX) specifically in tumor cells, and therefore clinically used as a reagent for photodynamic diagnosis (PDD) and therapy (PDT) of cancers including gliomas. However, it remains to be clarified whether this method could be effective for CSC detection. Here, using flow cytometry-based analysis, we show that side population (SP)-defined C6 glioma CSCs (GSCs) displayed much less 5-ALA-derived PpIX fluorescence than non-GSCs...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28024568/study-and-evaluation-of-nucleolin-targeted-delivery-of-magnetic-plga-peg-nanospheres-loaded-with-doxorubicin-to-c6-glioma-cells-compared-with-low-nucleolin-expressing-l929-cells
#7
Jafar Mosafer, Manouchehr Teymouri, Khalil Abnous, Mohsen Tafaghodi, Mohammad Ramezani
Magnetic nanoparticulate systems based on polymeric materials such as poly (lactic-co-glycolic acid) (PLGA(1)) are being studied for their potential applications in targeted therapy and imaging of malignant tumors. In the current study, superparamagnetic iron oxide nanocrystals (SPIONs(2)) and doxorubicin (Dox(3)) were entrapped in the PLGA-based nanoparticles via a modified multiple emulsion solvent evaporation method. Furthermore, SPIO/Dox-NPs(4) were conjugated to anti-nucleolin AS1411 aptamer (Apt(5)) and their targeting ability was investigated in high nucleolin-expressing C6 glioma cells compared to low nucleolin-expressing L929 cells...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27959443/an-epirubicin-peptide-conjugate-with-anticancer-activity-is-dependent-upon-the-expression-level-of-the-surface-transferrin-receptor
#8
Jiadan Yang, Qiyu Yang, Lu Xu, Jie Lou, Zhi Dong
Epirubicin (EPI) is one of the most widely used anticarcinogens; however, serious side effects, including cardiomyopathy and congestive heart failure, limit its long‑term administration. To overcome this problem, the HAIYPRH peptide ligand was used with EPI in the synthesis of a HAIYPRH‑EPI conjugate. The anticancer activity and cellular uptake of the conjugate were measured and evaluated. The results of the present study indicated that the cytotoxicity of HAIYPRH‑EPI was correlated with the expression of the cell surface transferrin receptor (TfR)...
January 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27898674/aberrations-in-the-iron-regulatory-gene-signature-are-associated-with-decreased-survival-in-diffuse-infiltrating-gliomas
#9
Cody Weston, Joe Klobusicky, Jennifer Weston, James Connor, Steven A Toms, Nicholas F Marko
Iron is a tightly regulated micronutrient with no physiologic means of elimination and is necessary for cell division in normal tissue. Recent evidence suggests that dysregulation of iron regulatory proteins may play a role in cancer pathophysiology. We use public data from The Cancer Genome Atlas (TCGA) to study the association between survival and expression levels of 61 genes coding for iron regulatory proteins in patients with World Health Organization Grade II-III gliomas. Using a feature selection algorithm we identified a novel, optimized subset of eight iron regulatory genes (STEAP3, HFE, TMPRSS6, SFXN1, TFRC, UROS, SLC11A2, and STEAP4) whose differential expression defines two phenotypic groups with median survival differences of 52...
2016: PloS One
https://www.readbyqxmd.com/read/27845960/meat-and-haem-iron-intake-in-relation-to-glioma-in-the-european-prospective-investigation-into-cancer-and-nutrition-study
#10
Heather A Ward, Alicia Gayle, Paula Jakszyn, Melissa Merritt, Beatrice Melin, Heinz Freisling, Elisabete Weiderpass, Anne Tjonneland, Anja Olsen, Christina C Dahm, Kim Overvad, Verena Katzke, Tilman Kühn, Heiner Boeing, Antonia Trichopoulou, Pagona Lagiou, Andreas Kyrozis, Domenico Palli, Vittorio Krogh, Rosario Tumino, Fulvio Ricceri, Amalia Mattiello, Bas Bueno-de-Mesquita, Petra H Peeters, José Ramón Quirós, Antonio Agudo, Miguel Rodriguez-Barranco, Nerea Larrañaga, José M Huerta, Aurelio Barricarte, Emily Sonestedt, Isabel Drake, Maria Sandström, Ruth C Travis, Pietro Ferrari, Elio Riboli, Amanda J Cross
Diets high in red or processed meat have been associated positively with some cancers, and several possible underlying mechanisms have been proposed, including iron-related pathways. However, the role of meat intake in adult glioma risk has yielded conflicting findings because of small sample sizes and heterogeneous tumour classifications. The aim of this study was to examine red meat, processed meat and iron intake in relation to glioma risk in the European Prospective Investigation into Cancer and Nutrition study...
November 11, 2016: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/27785017/recombinant-epidermal-growth-factor-like-domain-1-from-coagulation-factor-vii-functionalized-iron-oxide-nanoparticles-for-targeted-glioma-magnetic-resonance-imaging
#11
Heng Liu, Xiao Chen, Wei Xue, Chengchao Chu, Yu Liu, Haipeng Tong, Xuesong Du, Tian Xie, Gang Liu, Weiguo Zhang
The highly infiltrative and invasive nature of glioma cells often leads to blurred tumor margins, resulting in incomplete tumor resection and tumor recurrence. Accurate detection and precise delineation of glioma help in preoperative delineation, surgical planning and survival prediction. In this study, recombinant epidermal growth factor-like domain-1, derived from human coagulation factor VII, was conjugated to iron oxide nanoparticles (IONPs) for targeted glioma magnetic resonance (MR) imaging. The synthesized EGF1-EGFP-IONPs exhibited excellent targeting ability toward tissue factor (TF)-positive U87MG cells and human umbilical vein endothelial cells in vitro, and demonstrated persistent and efficient MR contrast enhancement up to 12 h for preclinical glioma models with high targeting specificity in vivo...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27768402/deferiprone-enhances-temozolomide-cytotoxicity-in-glioma-cells
#12
George A Alexiou, Paraskevi Gerogianni, Evrysthenis Vartholomatos, Athanasios P Kyritsis
Glioblastoma is the most malignant primary brain tumor with a median survival of 15 months. Temozolomide (TMZ) is the standard of care for these patients. Iron chelators have been shown to have anti-tumor activity; however, deferiprone (DFP), an orally administered iron chelator, has not been previously evaluated in gliomas. In the present study, we found that combination treatment in glioma cells with TMZ and DFP significantly reduced cell viability, produced cell cycle arrest at G2/M phase, and enhanced apoptosis...
November 25, 2016: Cancer Investigation
https://www.readbyqxmd.com/read/27723161/difference-in-the-intratumoral-distributions-of-extracellular-fluid-and-intravascular-mr-contrast-agents-in-glioblastoma-growth
#13
Jin Hee Kim, Ji-Yeon Suh, Dong-Cheol Woo, Yu Sub Sung, Woo-Chan Son, Yoon Seok Choi, Sang Joon Pae, Jeong Kon Kim
Contrast enhancement by an extracellular-fluid contrast agent (CA) (Gd-DOTA) depends primarily on the blood-brain-barrier permeability (bp), and transverse-relaxation change caused by intravascular T2 CA (superparamagnetic iron oxide nanoparticles, SPIONs) is closely associated with the blood volume (BV). Pharmacokinetic (PK) vascular characterization based on single-CA-using dynamic contrast-enhanced MRI (DCE-MRI) has shown significant measurement variation according to the molecular size of the CA. Based on this recognition, this study used a dual injection of Gd-DOTA and SPIONs for tracing the changes of bp and BV in C6 glioma growth (Days 1 and 7 after the tumor volume reached 2 mL)...
October 10, 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27671990/investigating-intracranial-tumour-growth-patterns-with-multiparametric-mri-incorporating-gd-dtpa-and-uspio-enhanced-imaging
#14
Jessica K R Boult, Marco Borri, Alexa Jury, Sergey Popov, Gary Box, Lara Perryman, Suzanne A Eccles, Chris Jones, Simon P Robinson
High grade and metastatic brain tumours exhibit considerable spatial variations in proliferation, angiogenesis, invasion, necrosis and oedema. Vascular heterogeneity arising from vascular co-option in regions of invasive growth (in which the blood-brain barrier remains intact) and neoangiogenesis is a major challenge faced in the assessment of brain tumours by conventional MRI. A multiparametric MRI approach, incorporating native measurements and both Gd-DTPA (Magnevist) and ultrasmall superparamagnetic iron oxide (P904)-enhanced imaging, was used in combination with histogram and unsupervised cluster analysis using a k-means algorithm to examine the spatial distribution of vascular parameters, water diffusion characteristics and invasion in intracranially propagated rat RG2 gliomas and human MDA-MB-231 LM2-4 breast adenocarcinomas in mice...
September 27, 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27523645/synthesis-of-tumor-targeted-folate-conjugated-fluorescent-magnetic-albumin-nanoparticles-for-enhanced-intracellular-dual-modal-imaging-into-human-brain-tumor-cells
#15
Xueqin Wang, Miaomiao Tu, Baoming Tian, Yanjie Yi, ZhenZhen Wei, Fang Wei
Superparamagnetic iron oxide nanoparticles (SPIO NPs), utilized as carriers are attractive materials widely applied in biomedical fields, but target-specific SPIO NPs with lower toxicity and excellent biocompatibility are still lacking for intracellular visualization in human brain tumor diagnosis and therapy. Herein, bovine serum albumin (BSA) coated superparamagnetic iron oxide, i.e. γ-Fe2O3 nanoparticles (BSA-SPIO NPs), are synthesized. Tumor-specific ligand folic acid (FA) is then conjugated onto BSA-SPIO NPs to fabricate tumor-targeted NPs, FA-BSA-SPIO NPs as a contrast agent for MRI imaging...
November 1, 2016: Analytical Biochemistry
https://www.readbyqxmd.com/read/27513597/antioxidative-theranostic-iron-oxide-nanoparticles-toward-brain-tumors-imaging-and-ros-production
#16
Sophie Richard, Ana Saric, Marianne Boucher, Christian Slomianny, Françoise Geffroy, Sébastien Mériaux, Yoann Lalatonne, Patrice X Petit, Laurence Motte
Gliomas are the most common primary brain tumor in humans. To date, the only treatment of care consists of surgical removal of the tumor bulk, irradiation, and chemotherapy, finally resulting in a very poor prognosis due to the lack of efficiency in diagnostics. In this context, nanomedicine combining both diagnostic and magnetic resonance imaging (MRI) and therapeutic applications is a relevant strategy referred to theranostic. Magnetic nanoparticles (NP) are excellent MRI contrast agents because of their large magnetic moment, which induces high transverse relaxivity (r2) characteristic and increased susceptibility effect (T2*)...
October 21, 2016: ACS Chemical Biology
https://www.readbyqxmd.com/read/27471565/magnetofection-based-on-superparamagnetic-iron-oxide-nanoparticles-weakens-glioma-stem-cell-proliferation-and-invasion-by-mediating-high-expression-of-microrna-374a
#17
Zhiguang Pan, Zhifeng Shi, Hua Wei, Fengyan Sun, Jianping Song, Yongyi Huang, Te Liu, Ying Mao
Glioma stem cells belong to a special subpopulation of glioma cells that are characterized by strong proliferation, invasion and drug resistance capabilities. Magnetic nanoparticles are nanoscale biological materials with magnetic properties. In this study, CD133(+) primary glioma stem cells were isolated from patients and cultured. Then, magnetic nanoparticles were used to mediate the transfection and expression of a microRNA-374a overexpression plasmid in the glioma stem cells. Transmission electron microscopy detected the presence of significant magnetic nanoparticle substances within the CD133(+) glioma stem cells after transfection...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27455648/2-deoxy-d-glucose-modified-magnetic-nanoparticles-with-dual-functional-properties-nanothermotherapy-and-magnetic-resonance-imaging
#18
Lingyun Zhao, Yajing Zheng, Hao Yan, WenSheng Xie, Xiaodan Sun, Ning Li, Jintian Tang
Superparamagnetic iron oxide nanoparticles (SPIONs) with appropriate surface chemistry have attracted wild attention in medical and biological application because of their current and potential usefulness such as magnetic resonance imaging (MRI) contrast enhancement, magnetic mediated hyperthermia (MMH), immunoassay, and in drug delivery, etc. In this study, we investigated the MRI contrast agents and MMH mediators properties of the novel 2-deoxy-D-glucose (2-DG) modified SPIONs. As a non-metabolizable glucose analogue, 2-DG can block glycolysis and inhibits protein glycosylation...
March 2016: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/27446489/ultrasound-magnetic-targeting-with-spio-dox-microbubble-complex-for-image-guided-drug-delivery-in-brain-tumors
#19
Ching-Hsiang Fan, Yu-Hang Cheng, Chien-Yu Ting, Yi-Ju Ho, Po-Hung Hsu, Hao-Li Liu, Chih-Kuang Yeh
One of the greatest challenges in the deployment of chemotherapeutic drugs against brain tumors is ensuring that sufficient drug concentrations reach the tumor, while minimizing drug accumulation at undesired sites. Recently, injection of therapeutic agents following blood-brain barrier (BBB) opening by focused ultrasound (FUS) with microbubbles (MBs) has been shown to enhance drug delivery in targeted brain regions. Nevertheless, the distribution and quantitative deposition of agents delivered to the brain are still hard to estimate...
2016: Theranostics
https://www.readbyqxmd.com/read/27427385/cancer-associated-isocitrate-dehydrogenase-mutations-induce-mitochondrial-dna-instability
#20
Joanne M Kingsbury, Nachiketha Shamaprasad, R Blake Billmyre, Joseph Heitman, Maria E Cardenas
A major advance in understanding the progression and prognostic outcome of certain cancers, such as low-grade gliomas, acute myeloid leukaemia, and chondrosarcomas, has been the identification of early-occurring mutations in the NADP(+)-dependent isocitrate dehydrogenase genes IDH1 and IDH2 These mutations result in the production of the onco-metabolite D-2-hydroxyglutarate (2HG), thought to contribute to disease progression. To better understand the mechanisms of 2HG pathophysiology, we introduced the analogous glioma-associated mutations into the NADP(+ )isocitrate dehydrogenase genes (IDP1, IDP2, IDP3) in Saccharomyces cerevisiae Intriguingly, expression of the mitochondrial IDP1(R148H) mutant allele results in high levels of 2HG production as well as extensive mtDNA loss and respiration defects...
August 15, 2016: Human Molecular Genetics
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