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Glioma AND exosome

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https://www.readbyqxmd.com/read/29713056/immunosuppressive-effects-of-hypoxia-induced-glioma-exosomes-through-myeloid-derived-suppressor-cells-via-the-mir-10a-rora-and-mir-21-pten-pathways
#1
Xiaofan Guo, Wei Qiu, Qinglin Liu, Mingyu Qian, Shaobo Wang, Zongpu Zhang, Xiao Gao, Zihang Chen, Hao Xue, Gang Li
While immunosuppressive environments mediated by myeloid-derived suppressor cells (MDSCs) have been well documented in glioma patients, the mechanisms of MDSC development and activation have not been clearly defined. Here, we elucidated a role for glioma-derived exosomes (GDEs) in potentiating an MDSC pathway. We isolated normoxia-stimulated and hypoxia-stimulated GDEs and studied their MDSC induction abilities in vivo and in vitro. Analyses of spleen and bone marrow MDSC proportions (flow cytometry) and reactive oxygen species (ROS), arginase activity, nitric oxide (NO), T-cell proliferation and immunosuppressive cytokine (IL-10 and TGF-β, ELISA) levels were used to assess MDSC expansion and functional capacity...
May 1, 2018: Oncogene
https://www.readbyqxmd.com/read/29642503/migration-invasion-of-malignant-gliomas-and-implications-for-therapeutic-treatment
#2
REVIEW
Ching-Ann Liu, Chia-Yu Chang, Kuo-Wei Hsueh, Hong-Lin Su, Tzyy-Wen Chiou, Shinn-Zong Lin, Horng-Jyh Harn
Malignant tumors of the central nervous system (CNS) are among cancers with the poorest prognosis, indicated by their association with tumors of high-level morbidity and mortality. Gliomas, the most common primary CNS tumors that arise from neuroglial stem or progenitor cells, have estimated annual incidence of 6.6 per 100,000 individuals in the USA, and 3.5 per 100,000 individuals in Taiwan. Tumor invasion and metastasis are the major contributors to the deaths in cancer patients. Therapeutic goals including cancer stem cells (CSC), phenotypic shifts, EZH2/AXL/TGF-β axis activation, miRNAs and exosomes are relevant to GBM metastasis to develop novel targeted therapeutics for GBM and other brain cancers...
April 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29556340/the-role-of-ptrf-cavin1-as-a-biomarker-in-both-glioma-and-serum-exosomes
#3
Kai Huang, Chuan Fang, Kaikai Yi, Xing Liu, Hongzhao Qi, Yanli Tan, Junhu Zhou, Ying Li, Mingyang Liu, Yuqing Zhang, Jingxuan Yang, Jianning Zhang, Min Li, Chunsheng Kang
Exosomes play critical roles in intercellular communication in both nearby and distant cells in individuals and organs. Polymerase I and transcript release factor (PTRF), also known as Cavin1, has previously been described as a critical factor in caveola formation, and aberrant PTRF expression has been reported in various malignancies. However, the function of PTRF in tumor progression remains controversial, and its role in glioma is poorly understood. In this study, we report that PTRF is associated with malignancy grade and poor prognosis in glioma patients...
2018: Theranostics
https://www.readbyqxmd.com/read/29540489/survivin-monoclonal-antibodies-detect-survivin-cell-surface-expression-and-inhibit-tumor-growth-in-vivo
#4
Robert A Fenstermaker, Sheila A Figel, Jing-Xin Qiu, Tara A Barone, Sanam Sahjram Dharma, Evan K Winograd, Phillip M Galbo, Laura M Wiltsie, Michael J Ciesielski
PURPOSE: Survivin is an inhibitor of apoptosis protein (IAP) that is highly expressed in many cancers and represents an attractive molecule for targeted cancer therapy. Although primarily regarded as an intracellular protein with diverse actions, survivin has also been identified in association with circulating tumor exosomes. EXPERIMENTAL DESIGN: We have reported that active specific vaccination with a long peptide surviving immunogen leads to the development of survivin-specific CD8-mediated tumor cell lysis and prolongation of survival in tumor-bearing mice...
March 14, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29460831/-isolation-of-extracellular-micro-vesicles-from-cell-culture-medium-comparative-evaluation-of-methods
#5
T A Shtam, R A Samsonov, A V Volnitskiy, R A Kamyshinsky, N A Verlov, M S Kniazeva, E A Korobkina, A S Orehov, A L Vasiliev, A L Konevega, A V Malek
Extracellular vesicles (EV) are secreted by cells of multicellular organisms. EV mediate specific mode of intercellular communication by "horizontal" exchange of substances and information. This phenomenon seems to have an essential biological significance and became a subject of intensive research. Biogenesis, structural and functional features of the EV is being commonly studies in in vitro condition. Several methods of EV isolation from cell culture medium are established, however selection of method might influence on obtained results...
January 2018: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/29415469/circsmarca5-inhibits-migration-of-glioblastoma-multiforme-cells-by-regulating-a-molecular-axis-involving-splicing-factors-srsf1-srsf3-ptb
#6
Davide Barbagallo, Angela Caponnetto, Matilde Cirnigliaro, Duilia Brex, Cristina Barbagallo, Floriana D'Angeli, Antonio Morrone, Rosario Caltabiano, Giuseppe Maria Barbagallo, Marco Ragusa, Cinzia Di Pietro, Thomas Birkballe Hansen, Michele Purrello
Circular RNAs (circRNAs) have recently emerged as a new class of RNAs, highly enriched in the brain and very stable within cells, exosomes and body fluids. To analyze their involvement in glioblastoma multiforme (GBM) pathogenesis, we assayed the expression of twelve circRNAs, physiologically enriched in several regions of the brain, through real-time PCR in a cohort of fifty-six GBM patient biopsies and seven normal brain parenchymas. We focused on hsa_circ_0001445 (circSMARCA5): it was significantly downregulated in GBM biopsies as compared to normal brain tissues ( p -value < 0...
February 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29383115/circulating-cd9-gfap-survivin-exosomes-in-malignant-glioma-patients-following-survivin-vaccination
#7
Phillip M Galbo, Michael J Ciesielski, Sheila Figel, Orla Maguire, Jingxin Qiu, Laura Wiltsie, Hans Minderman, Robert A Fenstermaker
Glioma cells release exosomes in culture and into the extracellular matrix in vivo . These nanobodies transport an array of biomolecules and are capable of mediating cell-cell communication. Circulating exosomes in cancer patients may be indicative of disease status and response to therapy. The inhibitor of apoptosis protein (IAP) survivin (SVN) promotes cancer cell proliferation, local immune suppression and resistance to chemotherapy and it is a potential cancer biomarker. We used imaging flow cytometry to perform quantitative measurements of circulating SVN+ exosomes in the serum of malignant glioma patients undergoing investigational treatment with an anti-survivin vaccine (SurVaxM)...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29327816/brain-cortex-microglia-derived-exosomes-nanoparticles-for-glioma-therapy
#8
Adriana-Natalia Murgoci, Dasa Cizkova, Petra Majerova, Eva Petrovova, Lubomir Medvecky, Isabelle Fournier, Michel Salzet
The function and integrity of the nervous system require interactive exchanges among neurons and glial cells. Exosomes and other extracellular vesicles (EVs) are emerging as a key mediator of intercellular communication, capable of transferring nucleic acids, proteins and lipids influencing numerous functional and pathological aspects of both donor and recipient cells. The immune response mediated by microglia-derived exosomes is most prominently involved in the spread of neuroinflammation, neurodegenerative disorders, and brain cancer...
January 12, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29163818/pediatric-brain-tumor-cells-release-exosomes-with-a-mirna-repertoire-that-differs-from-exosomes-secreted-by-normal-cells
#9
Ágota Tűzesi, Teresia Kling, Anna Wenger, Taral R Lunavat, Su Chul Jang, Bertil Rydenhag, Jan Lötvall, Steven M Pollard, Anna Danielsson, Helena Carén
High-grade gliomas (HGGs) are very aggressive brain tumors with a cancer stem cell component. Cells, including cancer stem cells, release vesicles called exosomes which contain small non-coding RNAs such as microRNAs (miRNAs). These are thought to play an important role in cell-cell communication. However, we have limited knowledge of the types of exosomal miRNAs released by pediatric HGG stem cells; a prerequisite for exploring their potential roles in HGG biology. Here we isolated exosomes released by pediatric glioma stem cells (GSCs) and compared their repertoire of miRNAs to genetically normal neural stem cells (NSCs) exosomes, as well as their respective cellular miRNA content...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29076027/serum-exosomal-mir-301a-as-a-potential-diagnostic-and-prognostic-biomarker-for-human-glioma
#10
Fengming Lan, Qin Qing, Qiang Pan, Man Hu, Huiming Yu, Xiao Yue
PURPOSE: Exosomal miRNAs that play an important role in cell-cell communication have attracted major attention as potential diagnostic and prognostic biomarkers for various cancers. The aim of this study was to determine the diagnostic/prognostic significance of serum exosomal miR-301a in glioma patients. METHODS: Quantitative real-time PCR was used to determine the serum exosomal expression levels of miR-301a. Kaplan-Meier survival analyses, Cox regression analyses and ROC working curve analyses were applied to assess the diagnostic and prognostic values of miR-301a in glioma patients...
February 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29076001/a-microrna-signature-from-serum-exosomes-of-patients-with-glioma-as-complementary-diagnostic-biomarker
#11
Alessandra Santangelo, Pietro Imbrucè, Beatrice Gardenghi, Laura Belli, Rina Agushi, Anna Tamanini, Silvia Munari, Alessandra Maria Bossi, Ilaria Scambi, Donatella Benati, Raffaella Mariotti, Gianfranco Di Gennaro, Andrea Sbarbati, Albino Eccher, Giuseppe Kenneth Ricciardi, Elisa Maria Ciceri, Francesco Sala, Giampietro Pinna, Giuseppe Lippi, Giulio Cabrini, Maria Cristina Dechecchi
Malignant gliomas, the most frequent primary brain tumors, are characterized by a dismal prognosis. Reliable biomarkers complementary to neuroradiology in the differential diagnosis of gliomas and monitoring for post-surgical progression are unmet needs. Altered expression of several microRNAs in tumour tissues from patients with gliomas compared to normal brain tissue have been described, thus supporting the rationale of using microRNA-based biomarkers. Although different circulating microRNAs were proposed in association with gliomas, they have not been introduced into clinical practice so far...
January 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29074968/coding-and-noncoding-landscape-of-extracellular-rna-released-by-human-glioma-stem-cells
#12
Zhiyun Wei, Arsen O Batagov, Sergio Schinelli, Jintu Wang, Yang Wang, Rachid El Fatimy, Rosalia Rabinovsky, Leonora Balaj, Clark C Chen, Fred Hochberg, Bob Carter, Xandra O Breakefield, Anna M Krichevsky
Tumor-released RNA may mediate intercellular communication and serve as biomarkers. Here we develop a protocol enabling quantitative, minimally biased analysis of extracellular RNAs (exRNAs) associated with microvesicles, exosomes (collectively called EVs), and ribonucleoproteins (RNPs). The exRNA complexes isolated from patient-derived glioma stem-like cultures exhibit distinct compositions, with microvesicles most closely reflecting cellular transcriptome. exRNA is enriched in small ncRNAs, such as miRNAs in exosomes, and precisely processed tRNA and Y RNA fragments in EVs and exRNPs...
October 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/29050084/-recent-progress-in-application-of-exosome-in-diagnosis-and-treatment-of-gliomas
#13
W W Xu, L M Wang, L H Teng
No abstract text is available yet for this article.
October 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29016925/divergent-evolution-of-temozolomide-resistance-in-glioblastoma-stem-cells-is-reflected-in-extracellular-vesicles-and-coupled-with-radiosensitization
#14
Delphine Garnier, Brian Meehan, Thomas Kislinger, Paul Daniel, Ankit Sinha, Bassam Abdulkarim, Ichiro Nakano, Janusz Rak
Background: Glioblastoma (GBM) is almost invariably fatal due to failure of standard therapy. The relapse of GBM following surgery, radiation, and systemic temozolomide (TMZ) is attributed to the ability of glioma stem cells (GSCs) to survive, evolve, and repopulate the tumor mass, events on which therapy exerts a poorly understood influence. Methods: Here we explore the molecular and cellular evolution of TMZ resistance as it emerges in vivo (xenograft models) in a series of human GSCs with either proneural (PN) or mesenchymal (MES) molecular characteristics...
January 22, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29016843/mesenchymal-stem-cells-as-natural-biofactories-for-exosomes-carrying-mir-124a-in-the-treatment-of-gliomas
#15
Frederick M Lang, Anwar Hossain, Joy Gumin, Eric N Momin, Yuzaburo Shimizu, Dan Ledbetter, Tal Shahar, Shinji Yamashita, Brittany Parker Kerrigan, Juan Fueyo, Raymond Sawaya, Frederick F Lang
Background: MicroRNAs (miRs) are promising new therapeutics for glioblastoma. However, which miRs are most effective against glioblastomas and how these miRs should be delivered are major unanswered problems. Methods: To identify potent antiglioma miRs, we selected 8 miRs based on a literature search and screened them against a panel of glioma stem cell (GSC) lines, representing all of the glioblastoma subtypes defined by The Cancer Genome Atlas. To address delivery, we tested the hypothesis that ex vivo cultured bone marrow-derived mesenchymal stem cells (MSCs) can package miRs into exosomes and that these engineered exosomes can systemically deliver antiglioma miRs to glioblastomas...
February 19, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/28948499/cd133-positive-u87-glioblastoma-cells-derived-exosomal-micrornas-in-hypoxia-versus-normoxia-microenviroment
#16
Guobin Zhang, Yunsheng Zhang, Sen Cheng, Zhen Wu, Fusheng Liu, Junting Zhang
Hypoxia is a major regulator of glioma development and aggressiveness. However, how CD133 positive U87 glioblastoma cells adapt to hypoxia and communicate with their surrounding microenvironment during tumor development remain important questions. Communication with host cells and stroma via exosomes represents one pathway by which tumors can modify their surroundings to achieve a tumor-permissive environment. MicroRNAs are thought to be essential actors of tumorigenesis as they are able to control the expression of numerous genes...
October 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28855213/exosomes-from-glioma-associated-mesenchymal-stem-cells-increase-the-tumorigenicity-of-glioma-stem-like-cells-via-transfer-of-mir-1587
#17
Javier Figueroa, Lynette M Phillips, Tal Shahar, Anwar Hossain, Joy Gumin, Hoon Kim, Andrew J Bean, George A Calin, Juan Fueyo, Edgar T Walters, Raghu Kalluri, Roel G Verhaak, Frederick F Lang
Tumor-stromal communications impact tumorigenesis in ways that are incompletely understood. Here, we show that glioma-associated human mesenchymal stem cells (GA-hMSC), a newly identified stromal component of glioblastoma, release exosomes that increase the proliferation and clonogenicity of tumor-initiating glioma stem-like cells (GSC). This event leads to a significantly greater tumor burden and decreased host survival compared with untreated GSCs in orthotopic xenografts. Analysis of the exosomal content identified miR-1587 as a mediator of the exosomal effects on GSCs, in part via downregulation of the tumor-suppressive nuclear receptor corepressor NCOR1...
November 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28844885/glioma-progression-through-the-prism-of-heat-shock-protein-mediated-extracellular-matrix-remodeling-and-epithelial-to-mesenchymal-transition
#18
REVIEW
Y Rajesh, Angana Biswas, Mahitosh Mandal
Glial tumor is one of the intrinsic brain tumors with high migratory and infiltrative potential. This essentially contributes to the overall poor prognosis by circumvention of conventional treatment regimen in glioma. The underlying mechanism in gliomagenesis is bestowed by two processes- Extracellular matrix (ECM) Remodeling and Epithelial to mesenchymal transition (EMT). Heat Shock Family of proteins (HSPs), commonly known as "molecular chaperons" are documented to be upregulated in glioma. A positive correlation also exists between elevated expression of HSPs and invasive capacity of glial tumor...
October 15, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28687495/extracellular-vesicles-novel-promising-delivery-systems-for-therapy-of-brain-diseases
#19
REVIEW
David Rufino-Ramos, Patrícia R Albuquerque, Vitor Carmona, Rita Perfeito, Rui Jorge Nobre, Luis Pereira de Almeida
Extracellular vesicles (EVs) are cell-derived membrane vesicles virtually secreted by all cells, including brain cells. EVs are a major term that includes apoptotic bodies, microvesicles and exosomes. The release of EVs has been recognized as an important modulator in cross-talking between neurons, astrocytes, microglia and oligodendrocytes, not only in central nervous system (CNS) physiology but also in neurodegenerative and neuroinflammatory disease states as well as in brain tumors, such as glioma. EVs are able to cross the blood brain barrier (BBB), spread to body fluids and reach distant tissues...
September 28, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28656228/glioma-cells-enhance-angiogenesis-and-inhibit-endothelial-cell-apoptosis-through-the-release-of-exosomes-that-contain-long-non-coding-rna-ccat2
#20
Hai-Li Lang, Guo-Wen Hu, Bo Zhang, Wei Kuang, Yong Chen, Lei Wu, Guo-Hai Xu
Angiogenesis is a key event in the progression of gliomas. Exosomes, as signaling extracellular organelles, modulate the tumor microenvironment and promote angiogenesis and tumor progression. We previously demonstrated that long intergenic non-coding RNA CCAT2 (linc-CCAT2) was overexpressed in glioma tissues and functioned to promote glioma progression. Therefore, this study aimed to explore an underlying mechanism of glioma cell-affected angiogenesis. First, qRT-PCR was used to determine the expression level of linc-CCAT2 in 4 glioma cell lines and 293T cells, and the results revealed that the U87-MG cells exhibited the highest expression level...
August 2017: Oncology Reports
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