Fenqing Shang, Shen-Chih Wang, Brendan Gongol, So Yun Han, Yoshitake Cho, Cara R Schiavon, Lili Chen, Yuanming Xing, Yingshuai Zhao, Ming'an Ning, Xuan Guo, Fangzhou He, Yuyang Lei, Liuyi Wang, Uri Manor, Traci Marin, Kun-Ta Chou, Ming He, Po-Hsun Huang, John Y-J Shyy, Atul Malhotra
RATIONALE: Obstructive sleep apnea (OSA)-induced endothelial cell (EC) dysfunction contributes to OSA-related cardiovascular sequelae. The mechanistic basis of endothelial impairment by OSA is unclear. OBJECTIVES: The goals of this study were to identify the mechanism of OSA-induced EC dysfunction and explore the potential therapies for OSA-accelerated cardiovascular disease. METHODS: The experimental methods include data mining, bioinformatics, EC functional analyses, OSA mouse models, and assessment of OSA human subjects...
October 3, 2022: American Journal of Respiratory and Critical Care Medicine