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OSA and endothelial function

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https://www.readbyqxmd.com/read/28327146/association-between-obstructive-sleep-apnea-severity-and-endothelial-dysfunction-in-patients-with-type-2-diabetes
#1
Vanessa Bironneau, François Goupil, Pierre Henri Ducluzeau, Marc Le Vaillant, Pierre Abraham, Samir Henni, Séverine Dubois, Audrey Paris, Pascaline Priou, Nicole Meslier, Claire Sanguin, Wojciech Trzépizur, Ramaroson Andriantsitohaina, Maria Carmen Martinez, Frédéric Gagnadoux
BACKGROUND: Obstructive sleep apnea (OSA) and type 2 diabetes (T2D) are associated with endothelial dysfunction a main predictor of late cardiovascular (CV) events. Despite the high prevalence of OSA in patients with T2D, the impact of OSA severity on endothelial function has not been clearly elucidated. The aim of this cross-sectional study was to determine whether increasing OSA severity is associated with poorer endothelial function in patients with T2D. METHODS: 140 patients with T2D and no overt CV disease underwent polysomnography, peripheral arterial tonometry, clinic blood pressure (BP) measurement, biological assessment for CV risk factors, daytime sleepiness and health related quality of life (HRQL) questionnaires...
March 21, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28183716/endothelial-dysfunction-in-children-with-obstructive-sleep-apnea-is-associated-with-elevated-lipoprotein-associated-phospholipase-a2-plasma-activity-levels
#2
Leila Kheirandish-Gozal, Mona F Philby, Zhuanghong Qiao, Abdelnaby Khalyfa, David Gozal
BACKGROUND: Obstructive sleep apnea (OSA) is a highly prevalent condition, especially in obese children, and has been associated with increased risk for endothelial dysfunction and dislipidemia, which are precursors of atherosclerosis. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is recognized as an independent risk factor for cardiovascular risk and atheromatous plaque activity. We hypothesized that Lp-PLA2 levels would be elevated in children with OSA, particularly among obese children who also manifest evidence of endothelial dysfunction...
February 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28144275/serum-of-obstructive-sleep-apnea-patients-impairs-human-coronary-endothelial-cell-migration
#3
Michał Hoffmann, Jacek Wolf, Anna Szyndler, Prachi Singh, Virend K Somers, Krzysztof Narkiewicz
INTRODUCTION: Endothelial cell migration and proliferation play an important role in the growth and development of new blood vessels and endothelium healing. This process occurs in response to injury, inflammation and immune reactions. Dysfunction of the endothelium may play a significant role in development and progression of cardiovascular disease related to sleep-disordered breathing. The aim of our study was to evaluate the chemo-attractant activity of serum from obstructive sleep apnea (OSA) and normal subjects on coronary artery endothelial cell migration...
February 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28141659/altered-plasma-fibrin-clot-properties-in-hypertensive-patients-with-obstructive-sleep-apnoea-are-improved-by-continuous-positive-airway-pressure-treatment
#4
Katarzyna Jóźwik-Plebanek, Aleksander Prejbisz, Ewa Wypasek, Barbara Pręgowska-Chwała, Katarzyna Hanus, Anna M Kaszuba, Magdalena Januszewicz, Przemysław Bieleń, Marek Kabat, Mariusz Kruk, Piotr Dobrowolski, Anna Klisiewicz, Paweł Śliwiński, Andrzej Januszewicz, Anetta Undas
AIM: We investigated plasma fibrin clot properties in high-risk hypertensive patients with obstructive sleep apnoea (OSA) and assessed the impact of continuous positive airway pressure (CPAP) treatment on clot phenotype. METHODS: We studied 50 hypertensive patients with clinically significant OSA (age 50.0 ± 8.8 years, 39 M, 11 F). In total, 38 hypertensive patients without OSA balanced for age, sex, blood pressure, cardiovascular risk factors, and metabolic status served as controls...
January 30, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28128967/impact-of-mandibular-advancement-therapy-on-endothelial-function-in-severe-obstructive-sleep-apnea
#5
Frédéric Gagnadoux, Jean-Louis Pépin, Bruno Vielle, Vanessa Bironneau, Frédérique Chouet-Girard, Sandrine Launois, Nicole Meslier, Jean-Claude Meurice, Xuan-Lan Nguyen, Audrey Paris, Pascaline Priou, Renaud Tamisier, Wojciech Trzepizur, François Goupil, Bernard Fleury
RATIONALE: Endothelial dysfunction, a major predictor of late cardiovascular events, is linked to the severity of obstructive sleep apnea (OSA). OBJECTIVES: To determine whether treatment with mandibular advancement device, the main alternative to continuous positive airway pressure, improves endothelial function in patients with severe OSA. METHODS: In this trial, we randomized patients with severe OSA and no overt cardiovascular disease to receive 2 months of treatment with either effective mandibular advancement device or a sham device...
January 27, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28117120/critical-review-cpap-and-weight-management-of-obstructive-sleep-apnea-cardiovascular-co-morbidities
#6
REVIEW
David W Hudgel
The cardiovascular co-morbidities of obstructive sleep apnea (OSA) are similar to those of obesity. Cardiovascular co-morbidities often are the cause of adverse outcomes in overweight/obese OSA patients. Continuous positive airway pressure (CPAP) therapy resolves the symptoms of OSA, but may, or may not lead to improvement of a given cardiovascular co-morbidity. The impact of CPAP on cardiovascular risk variables, adverse cardiovascular events in overweight/obese OSA patients has been evaluated primarily in prospective, uncontrolled cohort studies...
December 18, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28065687/restless-legs-syndrome-and-cardiovascular-disease-a-research-roadmap
#7
REVIEW
Daniel J Gottlieb, Virend K Somers, Naresh M Punjabi, John W Winkelman
In this paper, we first critically appraise the epidemiologic literature examining the association of restless legs syndrome (RLS) with cardiovascular disease (CVD) and then consider whether lessons learned from the study of cardiovascular consequences of other sleep disorders might inform a research agenda to examine the potential mechanisms of cardiovascular morbidity of RLS. Cross-sectional and longitudinal studies are both mixed as to whether there is a meaningful association of RLS and CVD. On the other hand, numerous cross-sectional and longitudinal observational studies have shown a strong association of obstructive sleep apnea (OSA) with CVD risk...
March 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28057852/endothelin-1-and-et-receptors-impair-left-ventricular-function-by-mediated-coronary-arteries-dysfunction-in-chronic-intermittent-hypoxia-rats
#8
Jin-Wei Wang, Ai-Ying Li, Qiu-Hong Guo, Ya-Jing Guo, James W Weiss, En-Sheng Ji
Obstructive sleep apnea (OSA) results in cardiac dysfunction and vascular endothelium injury. Chronic intermittent hypoxia (CIH), the main characteristic of OSAS, is considered to be mainly responsible for cardiovascular system impairment. This study is aimed to evaluate the role of endothelin-1(ET-1) system in coronary injury and cardiac dysfunction in CIH rats. In our study, Sprague-Dawley rats were exposed to CIH (FiO2 9% for 1.5 min, repeated every 3 min for 8 h/d, 7 days/week for 3 weeks). After 3 weeks, the left ventricular developed pressure (LVDP) and coronary resistance (CR) were measured with the langendorff mode in isolated hearts...
January 2017: Physiological Reports
https://www.readbyqxmd.com/read/27860068/effect-of-osa-on-hypoxic-and-inflammatory-markers-during-cpap-withdrawal-further-evidence-from-three-randomized-control-trials
#9
Chris D Turnbull, Valentina A Rossi, Peter Santer, Esther I Schwarz, John R Stradling, Nayia Petousi, Malcolm Kohler
BACKGROUND AND OBJECTIVE: Obstructive sleep apnoea (OSA) is associated with cardiovascular disease. Intermittent hypoxia, endothelial dysfunction and adipose tissue-mediated inflammation have all been linked to cardiovascular disease in OSA. We therefore explored the effect of OSA on relevant associated blood markers: adrenomedullin (ADM), endocan, endothelin-1 (ET-1), resistin and vascular endothelial growth factor (VEGF). METHODS: Patients with OSA, established on and compliant with continuous positive airways pressure (CPAP) therapy for >1 year were included from three randomized controlled trials, conducted at two centres...
November 18, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27843708/prospective-preliminary-in-vitro-investigation-of-a-magnetic-iron-oxide-nanoparticle-conjugated-with-ligand-cd80-and-vegf-antibody-as-a-targeted-drug-delivery-system-for-the-induction-of-cell-death-in-rodent-osteosarcoma-cells
#10
AnneMarie Kay Kovach, Jen M Gambino, Vina Nguyen, Zach Nelson, Taylor Szasz, Jun Liao, Lakiesha Williams, Sandra Bulla, Raj Prabhu
Target drug deliveries using nanotechnology are a novel consideration in the treatment of cancer. We present herein an in vitro mouse model for the preliminary investigation of the efficacy of an iron oxide nanoparticle complex conjugated to vascular endothelial growth factor (VEGF) antibody and ligand cluster of differentiation 80 (CD80) for the purpose of eventual translational applications in the treatment of human osteosarcoma (OSA). The 35 nm diameter iron oxide magnetic nanoparticles are functionalized with an n-hydroxysuccinimide biocompatible coating and are conjugated on the surface to proteins VEGF antibody and ligand CD80...
2016: BioResearch Open Access
https://www.readbyqxmd.com/read/27823723/chitinase-3-like-protein-1-ykl-40-as-a-marker-of-endothelial-dysfunction-in-obstructive-sleep-apnea
#11
Behrouz Jafari, Vahid Mohsenin
BACKGROUND: Obstructive sleep apnea (OSA) is a highly prevalent disorder affecting 15-24% of adults and triples the risk for hypertension independent of other risk factors. The exact mechanisms of endothelial dysfunction and variable susceptibility to hypertension in OSA are not entirely clear. No biomarker to date has been found to be associated with hypertension in OSA. Chitinase-3-like protein-1(YKL-40) is a circulating moiety with roles in injury, repair and angiogenesis that is dysregulated in atherosclerosis and correlates with increased cardiovascular morbidity and mortality...
September 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27817148/cpap-therapy-for-patients-with-sleep-apnea-and-type-2-diabetes-mellitus-improves-control-of-blood-pressure
#12
Jamie Chung Mei Lam, Agnes Yuen Kwan Lai, Terence Chi Chun Tam, Michele Mae Ann Yuen, Karen Siu Ling Lam, Mary Sau Man Ip
PURPOSE: Obstructive sleep apnea (OSA) is highly associated with type 2 diabetes mellitus (DM), and treatment of OSA may have a positive impact on cardiometabolic profile. This study investigates the effects of continuous positive airway pressure (CPAP) treatment on glycemic control and cardiometabolic parameters in patients with diabetes. METHODS: Diabetic patients, who were newly diagnosed of OSA with an apnea hypopnea index (AHI) ≥15 and HbA1c ≥7%, were randomly assigned to either CPAP treatment or no treatment (control) for 3 months...
November 5, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27693879/serum-from-obstructive-sleep-apnea-patients-induces-inflammatory-responses-in-coronary-artery-endothelial-cells
#13
Katherine E Zychowski, Bethany Sanchez, Rodrigo P Pedrosa, Geraldo Lorenzi-Filho, Luciano F Drager, Vsevolod Y Polotsky, Matthew J Campen
BACKGROUND AND AIMS: Obstructive sleep apnea (OSA) is characterized by intermittent airway obstruction and systemic hypoxia during sleep, which can contribute to an increase in reactive oxygen species, vascular remodeling, vasoconstriction and ultimately cardiovascular disease. Continuous positive airway pressure (CPAP) is a clinical therapy that maintains airway patency and mitigates several symptoms of OSA. However, it is currently unknown whether CPAP therapy also reduces the overall inflammatory potential in the circulation; to address this in an unbiased manner, we applied a novel endothelial biosensor approach, the serum cumulative inflammatory potential (SCIP) assay...
November 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27634792/effect-on-intermittent-hypoxia-on-plasma-exosomal-micro-rna-signature-and-endothelial-function-in-healthy-adults
#14
Abdelnaby Khalyfa, Chunling Zhang, Ahamed A Khalyfa, Glen E Foster, Andrew E Beaudin, Jorge Andrade, Patrick J Hanly, Marc J Poulin, David Gozal
STUDY OBJECTIVE: Intermittent hypoxia (IH) is associated with increased risk of cardiovascular disease. Exosomes are secreted by most cell types and released in biological fluids, including plasma, and play a role in modifying the functional phenotype of target cells. Using an experimental human model of IH, we investigated potential exosome-derived biomarkers of IH-induced vascular dysfunction. METHODS: Ten male volunteers were exposed to room air (D0), IH (6 h/day) for 4 days (D4) and allowed to recover for 4 days (D8)...
December 1, 2016: Sleep
https://www.readbyqxmd.com/read/27419627/circulating-exosomes-potentiate-tumor-malignant-properties-in-a-mouse-model-of-chronic-sleep-fragmentation
#15
Abdelnaby Khalyfa, Isaac Almendros, Alex Gileles-Hillel, Mahzad Akbarpour, Wojciech Trzepizur, Babak Mokhlesi, Lei Huang, Jorge Andrade, Ramon Farré, David Gozal
BACKGROUND: Chronic sleep fragmentation (SF) increases cancer aggressiveness in mice. Exosomes exhibit pleiotropic biological functions, including immune regulatory functions, antigen presentation, intracellular communication and inter-cellular transfer of RNA and proteins. We hypothesized that SF-induced alterations in biosynthesis and cargo of plasma exosomes may affect tumor cell properties. RESULTS: SF-derived exosomes increased tumor cell proliferation (~13%), migration (~2...
August 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27344563/endothelial-function-and-carotid-intima-media-thickness-in-obstructive-sleep-apnea-without-comorbidity
#16
Faraz A Farooqui, Surendra K Sharma, Atin Kumar, Manish Soneja, Kalaivani Mani, Ragesh Radhakrishnan, Nida Farooqui
PURPOSE: The objective of this study was to evaluate endothelial function and carotid intima media thickness (CIMT) in moderate to severe obstructive sleep apnea (OSA) without comorbidities. METHODS: It is an observational case control study in which endothelial function was assessed using flow-mediated dilatation (FMD) and peripheral arterial tonometry (PAT), and carotid artery ultrasound was used to measure CIMT in study group subjects that included 20 normotensive, non-diabetic, treatment naïve, and moderate to severe OSA patients, and 20 normotensive, non-diabetic, and non-OSA subjects served as a control group...
June 25, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27256793/8-isoprostanes-and-resistin-as-markers-of-vascular-damage-in-non-hypersomnolent-obstructive-sleep-apnoea-patients
#17
Radostina Vlaeva Cherneva, Zheina Vlaeva Cherneva, Ognian Borisov Georgiev, Daniela Stoichkova Petrova, Julia Ivanova Petrova
BACKGROUND: Oxidative stress and inflammation are assumed as the main pathological triggers for vascular damage in hypersomnolent obstructive sleep apnoea (OSA) patients, whereas their exact role in less symptomatic population is currently unknown. AIM: To determine whether oxidative stress (urinary 8-isoprostane concentration) and inflammation (plasma resistin levels) are associated with vascular damage in non-hypersomnolent (Epworth Sleep Score <11) OSA patients...
June 3, 2016: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/27163713/circulating-plasma-extracellular-microvesicle-microrna-cargo-and-endothelial-dysfunction-in-children-with-obstructive-sleep-apnea
#18
Abdelnaby Khalyfa, Leila Kheirandish-Gozal, Ahamed A Khalyfa, Mona F Philby, María Luz Alonso-Álvarez, Meelad Mohammadi, Rakesh Bhattacharjee, Joaquin Terán-Santos, Lei Huang, Jorge Andrade, David Gozal
RATIONALE: Obese children are at increased risk for developing obstructive sleep apnea (OSA), and both of these conditions are associated with an increased risk for endothelial dysfunction (ED) in children, an early risk factor for atherosclerosis and cardiovascular disease. Although weight loss and treatment of OSA by adenotonsillectomy improve endothelial function, not every obese child or child with OSA develops ED. Exosomes are circulating extracellular vesicles containing functional mRNA and microRNA (miRNA) that can be delivered to other cells, such as endothelial cells...
November 1, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27139243/obstructive-sleep-apnea-is-linked-to-depression-and-cognitive-impairment-evidence-and-potential-mechanisms
#19
Nancy A Kerner, Steven P Roose
Obstructive sleep apnea (OSA) is highly prevalent but very frequently undiagnosed. OSA is an independent risk factor for depression and cognitive impairment/dementia. Herein the authors review studies in the literature pertinent to the effects of OSA on the cerebral microvascular and neurovascular systems and present a model to describe the key pathophysiologic mechanisms that may underlie the associations, including hypoperfusion, endothelial dysfunction, and neuroinflammation. Intermittent hypoxia plays a critical role in initiating and amplifying these pathologic processes...
June 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27116287/endocan-a-novel-pred%C3%A4-ctor-of-endothel%C3%A4-al-dysfunct%C3%A4-on-%C3%A4-n-obstruct%C3%A4-ve-sleep-apnea-syndrome
#20
Asiye Kanbay, Erkan Ceylan, Handan İnönü Köseoğlu, Mustafa Çalışkan, Mumtaz Takir, Selcan Tulu, Ozge Telci Çaklılı, Osman Köstek, Aybala Erek, Baris Afsar
BACKGROUND AND AIM: Obstructive sleep apnea syndrome (OSA) is an independent risk factor for endothelial dysfunction and cardiometabolic diseases. Plasma endocan levels are elevated in a large number of diseases, and is a novel surrogate endothelial cell dysfunction marker. We aimed to assess the role of serum endocan level as a potential mechanism of endothelial dysfunction in OSA patients. MATERIALS AND METHODS: This was a cohort study in which patients who had undergone a sleep study for diagnosis of OSA were recruited...
April 26, 2016: Clinical Respiratory Journal
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