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Andrea Tovar-Garza, Mayela Meza-Resendiz, Elizabeth Guevara-Gutiérrez, Juan Gabriel Barrientos-García, Alberto Tlacuilo-Parra
BACKGROUND: Psoriasis in children and adolescents has not been well studied in Mexico. OBJECTIVE: To study the epidemiological characteristics of psoriasis in this age group. METHODS: This is a retrospective study in an academic, tertiary care dermatology center from January 1999 to December 2014. We included patients ≤ 18 years of age, with clinical and histopathological diagnosis of psoriasis. We recorded the following information: gender, age, disease duration, clinical variant, nail involvement, treatment, and family history...
January 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
Alejandra León, Mayela Del-Ángel, José Luis Ávila, Guillermo Delgado
Phthalides are a relatively small group of natural compounds confined to several plant families and some genera of fungi and liverworts. They are divided into two structural groups, the monomeric and dimeric phthalides, and known mainly as bioactive constituents of different plant species used traditionally for medicinal purposes in Asia, Europe, and North America.The first reports on the chemistry of phthalides appeared at the end of the nineteenth century, in which they were identified as the odor constituents of the essential oil of celery (Apium graveolens) by Ciamician and Silber (1897)...
2017: Progress in the Chemistry of Organic Natural Products
Mayela Cepeda-Vázquez, David Blumenthal, Valérie Camel, Barbara Rega
Furan, a possibly carcinogenic compound to humans, and furfural, a naturally occurring volatile contributing to aroma, can be both found in thermally treated foods. These process-induced compounds, formed by close reaction pathways, play an important role as markers of food safety and quality. A method capable of simultaneously quantifying both molecules is thus highly relevant for developing mitigation strategies and preserving the sensory properties of food at the same time. We have developed a unique reliable and sensitive headspace trap (HS trap) extraction method coupled to GC-MS for the simultaneous quantification of furan and furfural in a solid processed food (sponge cake)...
March 1, 2017: Talanta
Miguel Ángel Gómez-Sámano, Mariana Grajales-Gómez, Julia María Zuarth-Vázquez, Ma Fernanda Navarro-Flores, Mayela Martínez-Saavedra, Óscar Alfredo Juárez-León, Mariana G Morales-García, Víctor Manuel Enríquez-Estrada, Francisco J Gómez-Pérez, Daniel Cuevas-Ramos
Fibroblast growth factor 21 (FGF21) is an endocrine-member of the FGF family. It is synthesized mainly in the liver, but it is also expressed in adipose tissue, skeletal muscle, and many other organs. It has a key role in glucose and lipid metabolism, as well as in energy balance. FGF21 concentration in plasma is increased in patients with obesity, insulin resistance, and metabolic syndrome. Recent findings suggest that such increment protects tissue from an increased oxidative stress environment. Different types of physical stress, such as strenuous exercising, lactation, diabetic nephropathy, cardiovascular disease, and critical illnesses, also increase FGF21 circulating concentration...
April 2017: Redox Biology
Teresa Corona, Amin Cervantes-Arriaga, Leora Velásquez-Pérez, Mayela Rodríguez-Violante
BACKGROUND: Outpatient clinics for movement disorders provide specialized diagnosis and treatment services for the specific needs of this patient population. OBJECTIVE: Describe the impact of implementing a Movement Disorder Clinic on the trends of consultations per year and hospitalizations of subjects with Parkinson's disease at a tertiary referral center. METHODS: A retrospective study was carried out. We collected data from the Clinical File Archive and the Epidemiology Department at the National Institute of Neurology and Neurosurgery in Mexico...
July 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
Ana María Salinas-Martínez, Jimena Estefanía Gaspar-Rivera, Oscar Juárez-Pérez, José Roberto Montañez-Sauceda, Georgina Mayela Núñez-Rocha, Francisco Javier Guzmán-de-la-Garza, Álvaro Mathiew-Quirós
Failures in repeat mammography decrease the potential benefits of screening; however, it is notable that the recent use of mammography is more frequently studied than repeat use. We estimated the prevalence and analyzed determinants for repeat mammography among women from Mexico, a developing country of Latin America. It was a two-stage study with an initial cross-sectional design (n = 1045) and a final case-control design that involved women of at least 45 years of age with no history of breast, ovarian, or uterine cancer...
April 2017: Journal of Community Health
Laura Mayela Montes-Rincón, Lucio Galaviz-Silva, Francisco Ernesto González-Bravo, Zinnia Judith Molina-Garza
Chagas disease is caused by an infection with the protozoan hemoflagellate Trypanosoma cruzi, and it is a major endemic health problem in Latin America. The congenital route is one of the main non-vectorial pathways of transmission, which can arise either in the chronic or acute phase of maternal infection. Serological screening of T. cruzi infection was performed in 520 pregnant women and newborns at the Hospital General Regional de León, Guanajuato, Mexico, between 2014 and 2015. Anti-T. cruzi antibodies were detected in 20 mothers (4%) by ELISA and HIA with four PCR-positive newborn cases...
December 2016: Acta Tropica
Valmore Bermudez, Juan Salazar, María Sofía Martínez, Mervin Chávez-Castillo, Luis Carlos Olivar, María José Calvo, Jim Palmar, Jordan Bautista, Eduardo Ramos, Mayela Cabrera, Freddy Pachano, Joselyn Rojas
Background and Aim. Insulin resistance (IR) is a prominent pathophysiologic component in a myriad of metabolic disorders, including obesity, prediabetes, and type 2 diabetes mellitus, which are common in our locality. The objective of this study was to determine the prevalence of IR and factors associated with this condition in an adult population from Maracaibo city, Venezuela. Methodology. A cross-sectional, descriptive study with multistaged randomized sampling was carried out in 2026 adults. IR was defined as HOMA2-IR ≥ 2...
2016: Advances in Preventive Medicine
Sara Isais-Millán, Dan Piña-Fuentes, Christian Guzmán-Astorga, Amin Cervantes-Arriaga, Mayela Rodríguez-Violante
INTRODUCTION: Parkinson's disease is characterized by a broad spectrum of neuropsychiatric manifestations. Its pathophysiology has been associated with the disease itself as well as with the dopaminergic treatment. MATERIAL AND METHODS: A cross-sectional study was conducted in drug-naive patients with early Parkinson's disease. All participants were evaluated through a set of scales for specific neuropsychiatric symptoms including: cognition, depression, anxiety, apathy, psychosis, and impulse control disorder...
May 2016: Gaceta Médica de México
Valmore Bermúdez, Juan Salazar, Joselyn Rojas, María Calvo, Milagros Rojas, Mervin Chávez-Castillo, Roberto Añez, Mayela Cabrera
To determine the predictive power of various anthropometric indices for the identification of dysglycemic states in Maracaibo, Venezuela. A cross-sectional study with randomized, multi-staged sampling was realized in 2230 adult subjects of both genders who had their body mass index (BMI), waist circumference (WC) and waist-height ratio (WHR) determined. Diagnoses of type 2 diabetes mellitus (DM2) and impaired fasting glucose (IFG) were made following ADA 2015 criteria. ROC curves were used to evaluate the predictive power of each anthropometric parameter...
June 17, 2016: Journal of Community Health
Ildefonso Rodríguez-Leyva, Erika G Chi-Ahumada, Juan Carrizales, Mayela Rodríguez-Violante, Salvador Velázquez-Osuna, Verónica Medina-Mier, María G Martel-Gallegos, Sergio Zarazúa, Lourdes Enríquez-Macías, Adriana Castro, Ana Laura Calderón-Garcidueñas, María E Jiménez-Capdeville
OBJECTIVE: This study characterizes the expression of tau (p-tau) and α-synuclein (α-syn) by immunohistochemistry in the skin of three different populations: healthy control (HC), Parkinson disease (PD), and progressive supranuclear paralysis (PSP) subjects, with the purpose of finding a biomarker that could differentiate between subjects with PD and PSP. MATERIAL AND METHODS: We evaluated the presence of p-tau and α-syn in a pilot study in the skin of three distinct groups of patients: 17 healthy subjects, 17 patients with PD, and 10 patients with PSP...
March 2016: Annals of Clinical and Translational Neurology
Mayela Leal, Chetan Dhoble, Julie Lee, Deinymar Lopez, Laura Simonne Menéndez
Kearns-Sayre syndrome (KSS) was first described in 1958 as 'a rare neuromuscular disorder defined by a characteristic triad of progressive external ophthalmoplegia, pigmentary retinopathy, atrioventricular block and cerebellar ataxia'. The prevalence rate of KSS is ∼1-3 per 100 000 individuals. Here, we report a rare case of a 17-year-old Venezuelan male with KSS.
March 2016: Oxford Medical Case Reports
Leire Ambrosio, Mari Carmen Portillo, Carmen Rodriguez-Blazquez, Juan Carlos Martínez-Castrillo, Mayela Rodriguez-Violante, Marcos Serrano-Dueñas, Víctor Campos-Arillo, Nelida Susana Garretto, Tomoko Arakaki, Mario Álvarez, Ivonne Pedroso-Ibáñez, Ana Carvajal, Pablo Martinez-Martin
INTRODUCTION: To explore the psychometric attributes of a new Satisfaction with Life Scale (SLS-6) in a wide Spanish-speaking population with Parkinson's disease (PD). METHODS: This was an international, cross-sectional study. Several rater-based and patient-reported outcomes measures for evaluation of PD (e.g., Scales for Outcomes in Parkinson's Disease-Motor) and other constructs (e.g., Duke-UNC Functional Social Support Questionnaire, Scale for Living with Chronic Illness) were applied together with the SLS-6...
April 2016: Parkinsonism & related Disorders
Mayela Govea-Salas, Ana Maria Rivas-Estilla, Raul Rodríguez-Herrera, Sonia A Lozano-Sepúlveda, Cristobal N Aguilar-Gonzalez, Alejandro Zugasti-Cruz, Tanya B Salas-Villalobos, Jesus Antonio Morlett-Chávez
Gallic acid (GA) is a natural phenolic compound that possesses various biological effects, including antioxidant, anti-inflammatory, antibiotic, anticancer, antiviral and cardiovascular protection activities. In addition, numerous studies have reported that antioxidants possess antiviral activities. Hepatitis C virus (HCV) is one of the most important causes of chronic liver diseases worldwide, but until recently, only a small number of antiviral agents had been developed against HCV. Therefore, the present study investigated whether GA exhibits an anti-HCV activity...
February 2016: Experimental and Therapeutic Medicine
Amin Cervantes-Arriaga, Mayela Rodríguez-Violante, Hugo Morales-Briceño, Gabriel Neri-Nani, Roxanna Millán-Cepeda, Salvador Velázquez-Osuna
OBJECTIVE: To assess the frequency of postural and striatal deformities in patients with Parkinson's disease. PATIENTS AND METHODS: A total of 416 consecutive patients with Parkinson's disease were evaluated for musculoskeletal deformities using a standardized criteria. Data including disease history, motor complications and antiparkinsonic treatment were collected. RESULTS: The overall frequency of musculoskeletal deformities was 19.7%. Striatal deformities were the most frequent deformities (9...
March 2016: Clinical Neurology and Neurosurgery
Maribel Márquez-Cruz, Juan Pablo Díaz-Martínez, Herman Soto-Molina, Adib Jorge De Saráchaga, Amin Cervantes-Arriaga, Rodrigo Llorens-Arenas, Mayela Rodríguez-Violante
Parkinson's disease (PD) is the second most common neurodegenerative disease. There are no clinical trials comparing all available pharmacological therapies for the treatment of early PD. The objective of this review is to indirectly analyze the efficacy of antiparkinson drugs currently available in Latin America. A systematic review was performed exploring only placebo-controlled randomized trials comparing antiparkinson monotherapy (levodopa, pramipexole, rasagiline, or selegiline) in patients with PD on Hoehn and Yahr stages I through III published from January 1994 to May 2014...
2016: Expert Review of Pharmacoeconomics & Outcomes Research
Mayela Rodríguez-Violante, Adib Jorge de Saráchaga, Amin Cervantes-Arriaga, Roxanna Millán-Cepeda, Roberto Leal-Ortega, Ingrid Estrada-Bellmann, Carlos Zuñiga-Ramírez
BACKGROUND: Parkinson's disease is characterized by motor and non-motor clinical features. The latter may present as pre-motor symptoms several years before the motor onset. OBJECTIVE: To analyze the association between pre-motor symptoms load and its lead-time in relation to the motor onset and time to diagnosis. METHODS: A cross-sectional study was carried including subjects with Parkinson's disease from five different movement disorders clinics in Mexico...
2016: Journal of Parkinson's Disease
Mayela Rodríguez-Violante, Amin Cervantes-Arriaga, Paulina González-Latapí, Pablo León-Ortiz, Camilo de la Fuente-Sandoval, Teresa Corona
BACKGROUND: Psychosis prevalence in Parkinson's disease is estimated at 8-30%. Proton magnetic resonance spectroscopy measures specific metabolites as markers of cell functioning. OBJECTIVE: To study N-acetyl-aspartate and glutamate levels in the caudate and putamen nuclei in subjects with Parkinson's disease with and without psychosis. METHODS: We included 20 non-demented Parkinson's disease patients with psychosis and 20 Parkinson's disease patients without psychosis matched for age, sex, disease duration, and levodopa equivalent daily dose, all attended at an academic medical center...
July 2015: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
Alonso Alvarado-Bolaños, Amin Cervantes-Arriaga, Mayela Rodríguez-Violante, Rodrigo Llorens-Arenas, Humberto Calderón-Fajardo, Roxanna Millán-Cepeda, Roberto Leal-Ortega, Ingrid Estrada-Bellmann, Carlos Zuñiga-Ramírez
BACKGROUND: Neuropsychiatric symptoms in Parkinson's disease (PD) are frequent. Impact of neuropsychiatric symptoms on quality of life has recently become a relevant topic of research due to its potential to develop targeted therapies to improve quality of life. OBJECTIVE: To determine the impact of neuropsychiatric symptoms in patients with PD using the Parkinson's Disease Questionnaire Short Form (PDQ-8). METHODS: Consecutive patients with PD were evaluated with the Scale for Evaluation of Neuropsychiatric Disorders in Parkinson's disease (SEND-PD) and PDQ-8 scales separately...
2015: Journal of Parkinson's Disease
Adib Jorge de Saráchaga, Amin Cervantes-Arriaga, Rodrigo Llorens-Arenas, Humberto Calderón-Fajardo, Mayela Rodríguez-Violante
Background. Parkinson's disease (PD) is a chronic and progressive disorder. Rates of change in motor symptoms have been more studied compared to nonmotor symptoms. The objective was to describe these changes in a real-life cohort of subjects with PD. Methods. A cohort study was carried out from 2011 to 2013. Consecutive patients with PD were recruited from a movement disorders clinic. MDS-UPDRS, PDQ-8, and NMSS were applied to all subjects at an initial evaluation and a subsequent visit (21 ± 3 months). Disease severity was categorized using a recent classification of MDS-UPDRS severity...
2015: Neuroscience Journal
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