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https://www.readbyqxmd.com/read/28777324/regional-assessment-of-human-fecal-contamination-in-southern-california-coastal-drainages
#1
Yiping Cao, Meredith R Raith, Paul D Smith, John F Griffith, Stephen B Weisberg, Alexander Schriewer, Andrew Sheldon, Chris Crompton, Geremew G Amenu, Jason Gregory, Joe Guzman, Kelly D Goodwin, Laila Othman, Mayela Manasjan, Samuel Choi, Shana Rapoport, Syreeta Steele, Tommy Nguyen, Xueyuan Yu
Host-associated genetic markers that allow for fecal source identification have been used extensively as a diagnostic tool to determine fecal sources within watersheds, but have not been used in routine monitoring to prioritize remediation actions among watersheds. Here, we present a regional assessment of human marker prevalence among drainages that discharge to the U.S. southern California coast. Approximately 50 samples were analyzed for the HF183 human marker from each of 22 southern California coastal drainages under summer dry weather conditions, and another 50 samples were targeted from each of 23 drainages during wet weather...
August 4, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28716280/association-of-polymorphisms-and-reduced-expression-levels-of-the-nr4a2-gene-with-parkinson-s-disease-in-a-mexican-population
#2
Elizabeth Ruiz-Sánchez, Petra Yescas, Mayela Rodríguez-Violante, Nancy Martínez-Rodríguez, Jesica N Díaz-López, Adriana Ochoa, Sergio S Valdes-Rojas, Daniel Magos-Rodríguez, Julio C Rojas-Castañeda, Amin Cervantes-Arriaga, Samuel Canizales-Quinteros, Patricia Rojas
INTRODUCTION: The NR4A2 transcription factor is important in the development, survival and phenotype of dopaminergic neurons and it is postulated as a possible biomarker for Parkinson's disease (PD). Therefore, our aim was to analyze in a sample of a Mexican population with idiopathic PD, mutations (in two hotspot mutation regions) and two polymorphisms (rs34884856 in promotor and rs35479735 intronic regions) of the NR4A2 gene. We also evaluate the levels of NR4A2 gene expression in peripheral blood for a Mexican population, and identify whether they are associated with NR4A2 gene polymorphisms...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28644969/premotor-symptoms-and-the-risk-of-parkinson-s-disease-a-case-control-study-in-mexican-population
#3
Mayela Rodríguez-Violante, Adib Jorge de Saráchaga, Amin Cervantes-Arriaga, Ned Merari Davila-Avila, Edith Carreón-Bautista, Ingrid Estrada-Bellmann, Guillermo Parra-López, Diego Cruz-Fino, Francisco Pascasio-Astudillo
OBJECTIVES: To assess the prevalence of pre-motor symptoms and estimate the risk for developing Parkinson's disease in Mexican population. PATIENTS AND METHODS: A case-control study was carried out with consecutive subjects with Parkinson's disease from two different referral centers in Mexico. Gender- and age-matched controls were randomly selected from the participating hospitals. All subjects were assessed using a structured questionnaire for the assessment of pre-motor symptoms (hyposmia, depression, anxiety, constipation, and sleep disorders)...
September 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28612325/stages-of-change-for-mammography-among-mexican-women-and-a-decisional-balance-comparison-across-countries
#4
Ana María Salinas-Martínez, David Emmanuel Castañeda-Vásquez, Norma Guadalupe García-Morales, Norma Edith Oliva-Sosa, Laura Hermila de-la-Garza-Salinas, Georgina Mayela Núñez-Rocha, José Manuel Ramírez-Aranda
An analysis of the adoption of secondary preventive behaviors is significant in regions with disparities in mammography use and breast cancer survival. Therefore, we determined the cognitive factors and the degree to which they differentiate stages of change in mammography among Mexican women. We also compared the decisional balance performance at Mexico, Switzerland, South Korea, and the USA. A cross-sectional study was designed for women in the stages of precontemplation (n = 240), contemplation (n = 243), action (n = 205), maintenance (n = 311), and relapse (n = 348)...
June 14, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28466265/ips-cell-cultures-from-a-gerstmann-str%C3%A3-ussler-scheinker-patient-with-the-y218n-prnp-mutation-recapitulate-tau-pathology
#5
Andreu Matamoros-Angles, Lucía Mayela Gayosso, Yvonne Richaud-Patin, Angelique di Domenico, Cristina Vergara, Arnau Hervera, Amaya Sousa, Natalia Fernández-Borges, Antonella Consiglio, Rosalina Gavín, Rakel López de Maturana, Isidro Ferrer, Adolfo López de Munain, Ángel Raya, Joaquín Castilla, Rosario Sánchez-Pernaute, José Antonio Del Río
Gerstmann-Sträussler-Scheinker (GSS) syndrome is a fatal autosomal dominant neurodegenerative prionopathy clinically characterized by ataxia, spastic paraparesis, extrapyramidal signs and dementia. In some GSS familiar cases carrying point mutations in the PRNP gene, patients also showed comorbid tauopathy leading to mixed pathologies. In this study we developed an induced pluripotent stem (iPS) cell model derived from fibroblasts of a GSS patient harboring the Y218N PRNP mutation, as well as an age-matched healthy control...
May 2, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28445180/activation-of-the-cxcr4-chemokine-receptor-enhances-biological-functions-associated-with-b16-melanoma-liver-metastasis
#6
Mayela Mendt, Jose E Cardier
The CXCR4 chemokine receptor plays an essential role in the homing of cells to organs expressing its ligand, CXCL12. CXCR4 expressed on tumor cells might regulate their traffic during metastasis. Here, we investigated whether the activation of CXCR4 on B16 murine melanoma cells regulates biological functions associated with metastasis, in vitro and in vivo. Flow cytometry and PCR analysis showed that B16 constitutively expresses high levels of CXCR4 (CXCR4-B16). Biological assays showed that the activation of CXCR4, by its ligand CXCL12, increases the migration, invasion, and proliferation of CXCR4-B16...
August 2017: Melanoma Research
https://www.readbyqxmd.com/read/28239182/psoriasis-in-children-and-adolescents-epidemiological-study-of-280-patients-from-mexico
#7
Andrea Tovar-Garza, Mayela Meza-Resendiz, Elizabeth Guevara-Gutiérrez, Juan Gabriel Barrientos-García, Alberto Tlacuilo-Parra
BACKGROUND: Psoriasis in children and adolescents has not been well studied in Mexico. OBJECTIVE: To study the epidemiological characteristics of psoriasis in this age group. METHODS: This is a retrospective study in an academic, tertiary care dermatology center from January 1999 to December 2014. We included patients ≤ 18 years of age, with clinical and histopathological diagnosis of psoriasis. We recorded the following information: gender, age, disease duration, clinical variant, nail involvement, treatment, and family history...
January 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28160212/phthalides-distribution-in-nature-chemical-reactivity-synthesis-and-biological-activity
#8
REVIEW
Alejandra León, Mayela Del-Ángel, José Luis Ávila, Guillermo Delgado
Phthalides are a relatively small group of natural compounds confined to several plant families and some genera of fungi and liverworts. They are divided into two structural groups, the monomeric and dimeric phthalides, and known mainly as bioactive constituents of different plant species used traditionally for medicinal purposes in Asia, Europe, and North America.The first reports on the chemistry of phthalides appeared at the end of the nineteenth century, in which they were identified as the odor constituents of the essential oil of celery (Apium graveolens) by Ciamician and Silber (1897)...
2017: Progress in the Chemistry of Organic Natural Products
https://www.readbyqxmd.com/read/28107995/multivariate-optimization-of-headspace-trap-for-furan-and-furfural-simultaneous-determination-in-sponge-cake
#9
Mayela Cepeda-Vázquez, David Blumenthal, Valérie Camel, Barbara Rega
Furan, a possibly carcinogenic compound to humans, and furfural, a naturally occurring volatile contributing to aroma, can be both found in thermally treated foods. These process-induced compounds, formed by close reaction pathways, play an important role as markers of food safety and quality. A method capable of simultaneously quantifying both molecules is thus highly relevant for developing mitigation strategies and preserving the sensory properties of food at the same time. We have developed a unique reliable and sensitive headspace trap (HS trap) extraction method coupled to GC-MS for the simultaneous quantification of furan and furfural in a solid processed food (sponge cake)...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28039838/fibroblast-growth-factor-21-and-its-novel-association-with-oxidative-stress
#10
REVIEW
Miguel Ángel Gómez-Sámano, Mariana Grajales-Gómez, Julia María Zuarth-Vázquez, Ma Fernanda Navarro-Flores, Mayela Martínez-Saavedra, Óscar Alfredo Juárez-León, Mariana G Morales-García, Víctor Manuel Enríquez-Estrada, Francisco J Gómez-Pérez, Daniel Cuevas-Ramos
Fibroblast growth factor 21 (FGF21) is an endocrine-member of the FGF family. It is synthesized mainly in the liver, but it is also expressed in adipose tissue, skeletal muscle, and many other organs. It has a key role in glucose and lipid metabolism, as well as in energy balance. FGF21 concentration in plasma is increased in patients with obesity, insulin resistance, and metabolic syndrome. Recent findings suggest that such increment protects tissue from an increased oxidative stress environment. Different types of physical stress, such as strenuous exercising, lactation, diabetic nephropathy, cardiovascular disease, and critical illnesses, also increase FGF21 circulating concentration...
April 2017: Redox Biology
https://www.readbyqxmd.com/read/27623035/impact-of-a-movement-disorders-clinic-on-the-trends-of-parkinson-s-disease-consultations-at-a-tertiary-referral-center
#11
Teresa Corona, Amin Cervantes-Arriaga, Leora Velásquez-Pérez, Mayela Rodríguez-Violante
BACKGROUND: Outpatient clinics for movement disorders provide specialized diagnosis and treatment services for the specific needs of this patient population. OBJECTIVE: Describe the impact of implementing a Movement Disorder Clinic on the trends of consultations per year and hospitalizations of subjects with Parkinson's disease at a tertiary referral center. METHODS: A retrospective study was carried out. We collected data from the Clinical File Archive and the Epidemiology Department at the National Institute of Neurology and Neurosurgery in Mexico...
July 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/27613738/prevalence-and-determinants-of-repeat-mammography-among-women-from-a-developing-country
#12
Ana María Salinas-Martínez, Jimena Estefanía Gaspar-Rivera, Oscar Juárez-Pérez, José Roberto Montañez-Sauceda, Georgina Mayela Núñez-Rocha, Francisco Javier Guzmán-de-la-Garza, Álvaro Mathiew-Quirós
Failures in repeat mammography decrease the potential benefits of screening; however, it is notable that the recent use of mammography is more frequently studied than repeat use. We estimated the prevalence and analyzed determinants for repeat mammography among women from Mexico, a developing country of Latin America. It was a two-stage study with an initial cross-sectional design (n = 1045) and a final case-control design that involved women of at least 45 years of age with no history of breast, ovarian, or uterine cancer...
April 2017: Journal of Community Health
https://www.readbyqxmd.com/read/27596439/trypanosoma-cruzi-seroprevalence-in-pregnant-women-and-screening-by-pcr-and-microhaematocrit-in-newborns-from-guanajuato-mexico
#13
Laura Mayela Montes-Rincón, Lucio Galaviz-Silva, Francisco Ernesto González-Bravo, Zinnia Judith Molina-Garza
Chagas disease is caused by an infection with the protozoan hemoflagellate Trypanosoma cruzi, and it is a major endemic health problem in Latin America. The congenital route is one of the main non-vectorial pathways of transmission, which can arise either in the chronic or acute phase of maternal infection. Serological screening of T. cruzi infection was performed in 520 pregnant women and newborns at the Hospital General Regional de León, Guanajuato, Mexico, between 2014 and 2015. Anti-T. cruzi antibodies were detected in 20 mothers (4%) by ELISA and HIA with four PCR-positive newborn cases...
December 2016: Acta Tropica
https://www.readbyqxmd.com/read/27579182/prevalence-and-associated-factors-of-insulin-resistance-in-adults-from-maracaibo-city-venezuela
#14
Valmore Bermudez, Juan Salazar, María Sofía Martínez, Mervin Chávez-Castillo, Luis Carlos Olivar, María José Calvo, Jim Palmar, Jordan Bautista, Eduardo Ramos, Mayela Cabrera, Freddy Pachano, Joselyn Rojas
Background and Aim. Insulin resistance (IR) is a prominent pathophysiologic component in a myriad of metabolic disorders, including obesity, prediabetes, and type 2 diabetes mellitus, which are common in our locality. The objective of this study was to determine the prevalence of IR and factors associated with this condition in an adult population from Maracaibo city, Venezuela. Methodology. A cross-sectional, descriptive study with multistaged randomized sampling was carried out in 2026 adults. IR was defined as HOMA2-IR ≥ 2...
2016: Advances in Preventive Medicine
https://www.readbyqxmd.com/read/27335192/-prevalence-of-neuropsychiatric-disorders-in-drug-naive-subjects-with-parkinson-s-disease-pd
#15
Sara Isais-Millán, Dan Piña-Fuentes, Christian Guzmán-Astorga, Amin Cervantes-Arriaga, Mayela Rodríguez-Violante
INTRODUCTION: Parkinson's disease is characterized by a broad spectrum of neuropsychiatric manifestations. Its pathophysiology has been associated with the disease itself as well as with the dopaminergic treatment. MATERIAL AND METHODS: A cross-sectional study was conducted in drug-naive patients with early Parkinson's disease. All participants were evaluated through a set of scales for specific neuropsychiatric symptoms including: cognition, depression, anxiety, apathy, psychosis, and impulse control disorder...
May 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27315803/diabetes-and-impaired-fasting-glucose-prediction-using-anthropometric-indices-in-adults-from-maracaibo-city-venezuela
#16
Valmore Bermúdez, Juan Salazar, Joselyn Rojas, María Calvo, Milagros Rojas, Mervin Chávez-Castillo, Roberto Añez, Mayela Cabrera
To determine the predictive power of various anthropometric indices for the identification of dysglycemic states in Maracaibo, Venezuela. A cross-sectional study with randomized, multi-staged sampling was realized in 2230 adult subjects of both genders who had their body mass index (BMI), waist circumference (WC) and waist-height ratio (WHR) determined. Diagnoses of type 2 diabetes mellitus (DM2) and impaired fasting glucose (IFG) were made following ADA 2015 criteria. ROC curves were used to evaluate the predictive power of each anthropometric parameter...
June 17, 2016: Journal of Community Health
https://www.readbyqxmd.com/read/27042679/parkinson-disease-and-progressive-supranuclear-palsy-protein-expression-in-skin
#17
Ildefonso Rodríguez-Leyva, Erika G Chi-Ahumada, Juan Carrizales, Mayela Rodríguez-Violante, Salvador Velázquez-Osuna, Verónica Medina-Mier, María G Martel-Gallegos, Sergio Zarazúa, Lourdes Enríquez-Macías, Adriana Castro, Ana Laura Calderón-Garcidueñas, María E Jiménez-Capdeville
OBJECTIVE: This study characterizes the expression of tau (p-tau) and α-synuclein (α-syn) by immunohistochemistry in the skin of three different populations: healthy control (HC), Parkinson disease (PD), and progressive supranuclear paralysis (PSP) subjects, with the purpose of finding a biomarker that could differentiate between subjects with PD and PSP. MATERIAL AND METHODS: We evaluated the presence of p-tau and α-syn in a pilot study in the skin of three distinct groups of patients: 17 healthy subjects, 17 patients with PD, and 10 patients with PSP...
March 2016: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/26949540/a-rare-case-of-kearns-sayre-syndrome-in-a-17-year-old-venezuelan-male-with-bilateral-ptosis-as-the-initial-presentation
#18
Mayela Leal, Chetan Dhoble, Julie Lee, Deinymar Lopez, Laura Simonne Menéndez
Kearns-Sayre syndrome (KSS) was first described in 1958 as 'a rare neuromuscular disorder defined by a characteristic triad of progressive external ophthalmoplegia, pigmentary retinopathy, atrioventricular block and cerebellar ataxia'. The prevalence rate of KSS is ∼1-3 per 100 000 individuals. Here, we report a rare case of a 17-year-old Venezuelan male with KSS.
March 2016: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/26905015/satisfaction-with-life-scale-sls-6-first-validation-study-in-parkinson-s-disease-population
#19
MULTICENTER STUDY
Leire Ambrosio, Mari Carmen Portillo, Carmen Rodriguez-Blazquez, Juan Carlos Martínez-Castrillo, Mayela Rodriguez-Violante, Marcos Serrano-Dueñas, Víctor Campos-Arillo, Nelida Susana Garretto, Tomoko Arakaki, Mario Álvarez, Ivonne Pedroso-Ibáñez, Ana Carvajal, Pablo Martinez-Martin
INTRODUCTION: To explore the psychometric attributes of a new Satisfaction with Life Scale (SLS-6) in a wide Spanish-speaking population with Parkinson's disease (PD). METHODS: This was an international, cross-sectional study. Several rater-based and patient-reported outcomes measures for evaluation of PD (e.g., Scales for Outcomes in Parkinson's Disease-Motor) and other constructs (e.g., Duke-UNC Functional Social Support Questionnaire, Scale for Living with Chronic Illness) were applied together with the SLS-6...
April 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/26893656/gallic-acid-decreases-hepatitis-c-virus-expression-through-its-antioxidant-capacity
#20
Mayela Govea-Salas, Ana Maria Rivas-Estilla, Raul Rodríguez-Herrera, Sonia A Lozano-Sepúlveda, Cristobal N Aguilar-Gonzalez, Alejandro Zugasti-Cruz, Tanya B Salas-Villalobos, Jesus Antonio Morlett-Chávez
Gallic acid (GA) is a natural phenolic compound that possesses various biological effects, including antioxidant, anti-inflammatory, antibiotic, anticancer, antiviral and cardiovascular protection activities. In addition, numerous studies have reported that antioxidants possess antiviral activities. Hepatitis C virus (HCV) is one of the most important causes of chronic liver diseases worldwide, but until recently, only a small number of antiviral agents had been developed against HCV. Therefore, the present study investigated whether GA exhibits an anti-HCV activity...
February 2016: Experimental and Therapeutic Medicine
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