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Matthew T Koroscil, Andrew Skabelund
Introduction: Blastomyces dermatitidis is a dimorphic fungus endemic to the Mississippi River valley. We describe a rare case of chronic pulmonary blastomycosis complicated by large pulmonary cavitation in a young service member who was misdiagnosed with active pulmonary tuberculosis. Case Presentation: A 25-year-old active duty male presented to his primary care provider with complaints of hemoptysis, fatigue, weight loss, and fever. Computed tomography chest with contrast identified a large cavitary lesion in the right upper lobe (RUL)...
March 14, 2018: Military Medicine
H-L Lei, L-H Li, W-S Chen, W-N Song, Y He, F-Y Hu, X-J Chen, W-P Cai, X-P Tang
Talaromyces marneffei (T. marneffei) can cause talaromycosis, a fatal systemic mycosis, in patients with AIDS. With the increasing number of talaromycosis cases in Guangdong, China, we aimed to investigate the susceptibility of 189 T. marneffei clinical strains to eight antifungal agents, including three echinocandins (anidulafungin, micafungin, and caspofungin), four azoles (posaconazole, itraconazole, voriconazole, and fluconazole), and amphotericin B, with determining minimal inhibition concentrations (MIC) by Sensititre YeastOne™ YO10 assay in the yeast phase...
March 13, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Scott A Weisenberg
A 78-year-old man developed right knee pain and swelling without other systemic symptoms. He had travelled frequently to the Central Valley of California. He was diagnosed with coccidioidomycosis based on joint fluid culture. Coccidioidal complement fixation antibody titres were extremely elevated. Arthroscopic debridement and fluconazole therapy did not lead to satisfactory improvement. Subsequent open debridement and change to itraconazole was followed by resolution of clinical signs of infection.
March 13, 2018: BMJ Case Reports
Sergio Álvarez-Pérez, Marta E García, José L Blanco
Combination therapy has become popular in clinical practice, but limited data on the effects of combinations of antifungal agents is still available for most fungal pathogens. We studied the in vitro response of 30 genetically diverse clinical strains of the basidiomycetous lipophilic yeast Malassezia pachydermatis obtained from cases of canine otitis to several amphotericin B (AMB)-azole combinations. Broth microdilution checkerboard tests revealed that AMB antagonized the effects of itraconazole (ITC) and voriconazole (VRC) in 50% and 6...
March 8, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Shivaprakash M Rudramurthy, Shamanth A Shankarnarayan, Sunil Dogra, Dipika Shaw, Khurram Mushtaq, Raees A Paul, Tarun Narang, Arunaloke Chakrabarti
Dermatophytosis, the commonest superficial fungal infection, has gained recent attention due to its change of epidemiology and treatment failures. Despite availability of several effective antifungal agents against dermatophytes, the incidence of chronic infection, re-infection and treatment failures are on the rise. Trichophyton rubrum and Trichophyton interdigitale are the two frequent clinical isolates in India. Consecutive patients (n=195) with suspected dermatophytosis during second half of 2014 were included in this study...
March 12, 2018: Antimicrobial Agents and Chemotherapy
Ali Rezaei-Matehkolaei, Sadegh Khodavaisy, Mohamad Mahdi Alshahni, Takashi Tamura, Kazuo Satoh, Mahdi Abastabar, Gholam Reza Shokoohi, Bahram Ahmadi, Mohammad Kord, Simin Taghipour, Koichi Makimura, Hamid Badali
The objective was to assess the in vitro activity of the novel triazole antifungal drug, efinaconazole, and five comparators (luliconazole, lanoconazole, terbinafine, itraconazole and fluconazole) against a large collection of Trichophyton interdigitale and Trichophyton rubrum clinical isolates. The geometric mean MICs were the lowest for luliconazole (0.0005 μg/mL), followed by lanoconazole (0.002 μg/mL), efinaconazole (0.007 μg/mL), terbinafine (0.011 μg/mL), itraconazole (0.095 μg/mL) and fluconazole (12...
March 12, 2018: Antimicrobial Agents and Chemotherapy
Mahdi Abastabar, Abdullah M S Al-Hatmi, Mohammad Vafaei Moghaddam, G Sybren de Hoog, Iman Haghani, Seyed Reza Aghili, Tahereh Shokohi, Mohammad Taghi Hedayati, Roshanak Daie Ghazvini, Reza Kachuei, Ali Rezaei-Matehkolaei, Koichi Makimura, Jacques F Meis, Hamid Badali
A collection of clinical (n=47) and environmental (n=79) Fusarium isolates were tested against 10 antifungal drugs, including two novel imidazoles. Luliconazole and lanoconazole demonstrated very low GM MIC values of 0.005 μg/ml and 0.013 μg/ml, respectively, in comparison with 0.51 μg/ml for micafungin, 0.85 μg/ml for efinaconazole, 1.12 μg/ml for natamycin, 1.18 μg/ml for anidulafungin, 1.31 μg/ml for voriconazole, 1.35 μg/ml for caspofungin, 1.9 μg/ml for amphotericin B and 4.08 μg/ml for itraconazole...
March 12, 2018: Antimicrobial Agents and Chemotherapy
P Kooshki, A Rezaei-Matehkolaei, A Z Mahmoudabadi
OBJECTIVE: Usually, 7-20% of preterm neonates colonized by Candida species present invasive candidiasis. Candida albicans, and several non-albicans species cause invasive infection with C. albicans being the most dominant agent. In the last two decades, infection due to non-albicans have been increased dramatically due to their low sensitivity to antifungal drugs such as fluconazole. The aim of present study was to evaluate Candida colonization pattern and antifungal susceptibility among preterm neonates from Khorramabad, South west of Iran...
March 9, 2018: Journal de Mycologie Médicale
Ju-Hyun Kim, Won-Gu Choi, Ju-Yeon Moon, Joo Young Lee, Sangkyu Lee, Hye Suk Lee
Itraconazole (ITZ) is a first-generation triazole-containing antifungal agent that effectively treats various fungal infections. As ITZ has a better safety profile than that of ketoconazole (KCZ), ITZ has been used worldwide for over 25 years. However, few reports have explored the metabolic profile of ITZ, and the underlying mechanism of ITZ-induced liver injury is not clearly understood. In the present study, we revisited ITZ metabolism in humans, using a non-targeted metabolomics approach, and identified several novel metabolic pathways including O-dearylation, piperazine oxidation, and piperazine-N,N'-deethylation...
March 7, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
N Fakhfakh, R Abdelmlak, S Aissa, A Kallel, Y Boudawara, S Bel Hadj, N Ben Romdhane, H Touiri Ben Aissa, K Kallel
Histoplasmosis is a fungal infection caused by a dimorphic fungus, Histoplasma capsulatum. We report a first case of disseminated histoplasmosis in a 34-year-old woman, infected with human immunodeficiency virus (HIV), originating from Ivory Coast and living in Tunisia for 4 years. She was complaining from fever, chronic diarrhoea and pancytopenia. The Histoplasma capsulatum var. capsulatum was identified by direct microscopic examination of the bone marrow. She was treated by Amphotericin B, relayed by itraconazole...
March 5, 2018: Journal de Mycologie Médicale
Kenneth Crombie, Zandile Spengane, Michael Locketz, Sipho Dlamini, Rannakoe Lehloenya, Sean Wasserman, Tsidiso G Maphanga, Nelesh P Govender, Chris Kenyon, Ilan S Schwartz
No abstract text is available yet for this article.
March 2018: PLoS Neglected Tropical Diseases
Raimunda Sâmia Nogueira Brilhante, Edmilson Emanuel Monteiro Correia, Glaucia Morgana de Melo Guedes, Jonathas Sales de Oliveira, Débora de Souza Collares Maia Castelo-Branco, Rossana de Aguiar Cordeiro, Adriana de Queiroz Pinheiro, Lúcio Jackson Queiroz Chaves, Waldemiro de Aquino Pereira Neto, José Júlio Costa Sidrim, Marcos Fábio Gadelha Rocha
BACKGROUND: As shown by recent researches, most of the clinically relevant fungi, including dermatophytes, form biofilms in vitro and in vivo, which may present antimicrobial tolerance favoring recurrent infections. OBJECTIVES: The aim of this study was to determine the minimum inhibitory concentrations (MICs) of itraconazole (ITC), voriconazole (VCZ) and griseofulvin (GRI) against Trichophyton rubrum, Trichophyton tonsurans, Trichophyton mentagrophytes, Microsporum canis and Microsporum gypseum, in planktonic and biofilm growth...
March 8, 2018: Mycoses
Gregorio J Petrirena, Julien Masliah-Planchon, Quentin Sala, Bertrand Pourroy, Didier Frappaz, Emeline Tabouret, Thomas Graillon, Jean-Claude Gentet, Olivier Delattre, Olivier Chinot, Laetitia Padovani
Background: Response to targeting and non-targeting agents is variable and molecular information remains poorly described in patients with recurrent sonic-hedgehog-driven medulloblastoma (SHH-MB). Materials and Methods: Clinical and PET/CT findings during treatment with successive hedgehog antagonists and temozolomide monotherapies are described in a heavily pre-treated patient with recurrent extraneural metastases from PTCH1 mutated/ wild type smoothened ( SMO ) CNS SHH-MB...
February 9, 2018: Oncotarget
Franco Pattarino, Greg Piepel, Maurizio Rinaldi
A paper by Foglio Bonda et al. published previously in this journal (2016, Vol. 83, pp. 175-183) discussed the use of mixture experiment design and modeling methods to study how the proportions of three components in an extemporaneous oral suspension affected the mean diameter of drug particles (Zave ). The three components were itraconazole (ITZ), Tween 20 (TW20), and Methocel® E5 (E5). This commentary addresses some errors and other issues in the previous paper, and also discusses an improved model relating proportions of ITZ, TW20, and E5 to Zave ...
March 3, 2018: European Journal of Pharmaceutical Sciences
Susana Córdoba, Guillermina Isla, Wanda Szusz, Walter Vivot, Alejandra Hevia, Graciela Davel, Cristina E Canteros
We studied 23 clinical and environmental strains of Sporothrix schenckii sensu lato collected from 1984 to 2017 in Argentina. The molecular identification (partial sequencing of a fragment of the calmodulin gene) of the strains was performed. For the yeast and mycelial phases, the in vitro susceptibility testing by a microdilution reference method was determined against eight antifungal drugs. Strains studied were identified as S. schenckii sensu stricto 13 (56.5%), S. brasiliensis 8 (34.7%) and S. globosa 2 (8...
March 3, 2018: Mycoses
A R Khosravi, P Mansouri, Z Saffarian, G Vahedi, D Nikaein
Chronic mucocutaneous candidiasis (CMC) is a clinically heterogeneous disease. Some immunologic and hormonal abnormalities have been associated with CMC. The factors that predispose host to CMC infection could be autosomal or acquisitive. The disease usually occurs in childhood. Here, we reviewed the published literature on chronic mucocutaneous candidiasis and a four years old girl is presented with CMC. She had a history of recurrent thrush and otomycosis since the age of one. Candida albicans was detected in skin scraping and biopsy samples...
February 27, 2018: Journal de Mycologie Médicale
A Vaezi, H Fakhim, J Javidnia, S Khodavaisy, Z Abtahian, M Vojoodi, F Nourbakhsh, H Badali
Tricyclazole as a common fungicide wildly used to control rice blast disease in the Asian country may induce azole resistance in Aspergillus fumigatus isolates. The main reason of the acquired azole resistance is probably environmental exposure through wide fungicide use in agriculture. The present study was conducted with the aim of investigating the current status of the azole-resistant A. fumigatus obtained from the paddy fields with exposure to tricyclazole. A total of 108 soil samples were collected from four different locations of paddy fields in Mazandaran Province, Iran...
February 26, 2018: Journal de Mycologie Médicale
Francisco Márquez, Isabel Iturrieta, Mario Calvo, Milton Urrutia, Patricio Godoy-Martínez
BACKGROUND: Candidemia disease in Chile is not very known, despite being a very common and serious disease. AIM: To analyze incidence and susceptibility profile of species from the genus Candida in Hospital Base Valdivia. MATERIAL AND METHODS: All candidemia cases presented between March 2009 and August 2011 in our institution were identified. Species distribution and susceptibility were studied through the disk diffusion method. RESULTS: Twenty-seven candidemia episodes were studied...
October 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Parisa Badiee, Maral Choopanizadeh, Abdolkarim Ghadimi Moghadam, Ali Hossaini Nasab, Hadis Jafarian, Ahmad Shamsizadeh, Jafar Soltani
Background and Objectives: Colonization of Candida species is common in pediatric patients admitted to hematology-oncology wards. The aim of this study was to identify colonized Candida species and their susceptibility patterns in hematologic pediatric patients. Materials and Methods: Samples were collected from mouth, nose, urine and stool of the patients admitted to five university hospitals and cultured on sabouraud dextrose agar. The isolates were identified by API 20 C AUX system and their susceptibility patterns were evaluated by CLSI M27-A3 and S4...
December 2017: Iranian Journal of Microbiology
Arthur J Morris, Karen Rogers, Wendy P McKinney, Sally A Roberts, Joshua T Freeman
OBJECTIVES: We have reviewed the susceptibility results of local yeast isolates performed 2001-2015 to record the impact of recently updated interpretive criteria, and epidemiological cutoff values (ECVs), for yeast species. METHODS: Testing was performed using Sensititre® YeastOne® and results interpreted following CLSI criteria or YeastOne derived ECVs. RESULTS: 2345 isolates were tested; 62% were from sterile body sites or tissue. Application of the new CLSI interpretative criteria for fluconazole increased the proportion of non-susceptible isolates of C...
February 24, 2018: Journal of Global Antimicrobial Resistance
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