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https://www.readbyqxmd.com/read/29785921/case-report-successful-treatment-of-chromoblastomycosis-caused-by-fonsecaea-monophora-in-a-patient-with-psoriasis-using-itraconazole-and-acitretin
#1
Fangfang Bao, Qihua Wang, Changping Yu, Panpan Shang, Lele Sun, Guizhi Zhou, Mei Wu, Furen Zhang
Chromoblastomycosis is a worldwide chronic subcutaneous infection caused by dematiaceous fungi and clinically characterized by verrucous lesions. Herein, we report a rare case of chromoblastomycosis caused by Fonsecaea monophora in a 60-year-old male carpenter with a 40-year history of psoriasis from Shandong in northern China. A fungal infection coexisting with psoriasis presents a management dilemma. Our patient responded well to combined itraconazole and acitretin therapy and the lesions resolved completely after 1 month of treatment...
May 21, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29785613/neuroinfections-caused-by-fungi
#2
REVIEW
Katarzyna Góralska, Joanna Blaszkowska, Magdalena Dzikowiec
BACKGROUND: Fungal infections of the central nervous system (FIs-CNS) have become significantly more common over the past 2 decades. Invasion of the CNS largely depends on the immune status of the host and the virulence of the fungal strain. Infections with fungi cause a significant morbidity in immunocompromised hosts, and the involvement of the CNS may lead to fatal consequences. METHODS: One hundred and thirty-five articles on fungal neuroinfection in PubMed, Google Scholar, and Cochrane databases were selected for review using the following search words: "fungi and CNS mycoses", CNS fungal infections", "fungal brain infections", " fungal cerebritis", fungal meningitis", "diagnostics of fungal infections", and "treatment of CNS fungal infections"...
May 21, 2018: Infection
https://www.readbyqxmd.com/read/29784842/eucast-determination-of-olorofim-f901318-susceptibility-of-mould-species-method-validation-and-mics
#3
Karin Meinike Jørgensen, Karen M T Astvad, Rasmus Krøger Hare, Maiken Cavling Arendrup
Olorofim is a novel antifungal agent with in vitro activity against Aspergillus and some other moulds. Here we addressed technical aspects for EUCAST olorofim testing and generated contemporary MIC data.EUCAST E.Def 9.3.1 testing was performed comparing two plate preparation methods (serial-dilution in medium (serial-plates) versus pre-dilution in DMSO (ISO-plates)), two lots of olorofim, visual (visual-MIC) versus spectrophotometer (spec-MIC) reading and four polystyrene plates using 34-53 Aspergillus isolates from five genera...
May 21, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29778564/simultaneous-quantification-of-systemic-azoles-and-their-major-metabolites-in-human-serum-by-hplc-pda-role-of-azole-metabolic-rate
#4
Alicia Gomez-Lopez, Laura Alcazar-Fuoli, Leticia Bernal-Martínez
We describe the development and validation of a novel liquid chromatography assay (HPLC/PDA) for simultaneous quantification of voriconazole, itraconazole, and posaconazole, as well as some of their major metabolites, voriconazole N-oxide and hydroxy-itraconazole, in human serum. Analytes were detected using a PDA system that allows the characterization of the specific UV spectra of each compound. The assay exhibited linearity between 0.25-16 mg/L for all the compounds tested. The accuracy and within- and between-day precision of the assay were in acceptable ranges...
April 14, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29777022/further-studies-to-support-the-use-of-coproporphyrin-i-and-iii-as-novel-clinical-biomarkers-for-evaluating-the-potential-for-organic-anion-transporting-polypeptide-oatp-1b1-and-oatp1b3-inhibition
#5
Hong Shen, Lisa Christopher, Yurong Lai, Jiachang Gong, Hamza Kandoussi, Samira Garonzik, Vidya Perera, Tushar Garimella, W Griffith Humphreys
In a recent study, limited to South Asian Indian subjects (n=12), coproporphyrin I and III (CPI and CPIII) demonstrated properties appropriate for an OATP1B endogenous probe (Lai et al., 2016). The current studies were conducted in healthy volunteers of mixed ethnicities, including black, white, and Hispanic subjects to better understand the utility of these biomarkers in broader populations. After oral administration with 600 mg rifampin, AUC(0-24h) values were 2.8-, 3.7- and 3.6-fold higher than predose levels for CPI and 2...
May 18, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29770723/the-impact-of-azole-antifungal-drugs-on-imatinib-metabolism-in-human-liver-microsomes
#6
Xingxian Luo, Taifeng Li, Ze Yu, Xuecai Xue, Haiyang Zhao, Na Li, Liping Ma, Changqing Yang, Lin Huanglin, Wangyu Feng
1. Imatinib is widely used for the treatment of hematologic malignancies. It is common that imatinib is clinically co-prescribed with azole antifungal agents since these patients are more prone to invasive antifungal infection. The present study was to investigate the effects of azole antifungal drugs, including ketoconazole, fluconazole, voriconazole, itraconazole and posaconazole on imatinib metabolism. 2. The main metabolites, 1-OH midazolam and N-desmethyl imatinib, were determined in the absence and in the presence of various levels of ketoconazole, fluconazole, voriconazole, itraconazole and posaconazole...
May 17, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29768236/rapid-synthesis-of-bi-2-o-3-nano-needles-via-green-route-and-evaluation-of-its-anti-fungal-activity
#7
Abhishek R Indurkar, Viraj D Sangoi, Prashant B Patil, Mansingraj S Nimbalkar
Here, the authors report a rapid, simple, and eco-friendly process for synthesis of Bi2 O3 nano-needles. Dioscorea alata tuber extract was used as both reducing and capping agent for the first time. These nanoparticles were characterised by X-ray diffraction, field emission scanning electron microscope, and Fourier transform infrared (FTIR) spectrometry, the nano-structured Bi2 O3 needles have an average diameter of 158 nm with the lengths in the range of 1-3 μm. CLSI M27-A2 standard was followed for evaluation of anti-fungal activity...
June 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29767317/successful-sequential-treatment-with-itraconazole-and-ala-pdt-for-cutaneous-granuloma-by-candida-albicans-a-case-report-and-literature-review
#8
Qing Cai, Lian-Juan Yang, Jia Chen, Hong Yang, Zhi-Qin Gao, Xiu-Li Wang
Photodynamic therapy (PDT) is a process that combines a photosensitizing drug and light and promotes phototoxic responses in target cells, mainly via oxidative damage. Antifungal photodynamic therapy has been successfully employed against Candida species, dermatophytes, and deep mycoses. We present a case of a cutaneous granuloma caused by C. albicans treated with 5-aminolevulinic acid (ALA)-PDT. A 64-year-old man presented with two plaques on his right hand and wrist for 2 years. The diagnosis was made based on histopathology, mycology, and molecular identification of paraffin-embedded tissues...
May 16, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29766657/drug-drug-interaction-and-doping-effect-of-non-prohibited-drugs-on-the-urinary-excretion-profile-of-methandienone
#9
Monica Mazzarino, Franziska L Khevenhüller-Metsch, Ilaria Fiacco, Maria Kristina Parr, Xavier de la Torre, Francesco Botrè
The potential consequences of drug-drug interactions on the excretion profile of the anabolic androgenic steroid methandienone (17β-hydroxy-17α-methylandrosta-1,4-dien-3-one) are discussed here. More specifically, we have evaluated by in vitro and in vivo experiments the effects of seven non-prohibited drugs (fluconazole, ketoconazole, itraconazole, miconazole, fluoxetine, paroxetine and nefazodone) on the main metabolic pathways of methandienone. These are selected among those most commonly used by the athletes...
May 15, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29761326/fusariosis-in-a-captive-south-american-sea-lion-otaria-flavescens-a-case-report
#10
Laura Reisfeld, Carlos Sacristán, Paloma Canedo, Bruna Schwarz, Ana Carolina Ewbank, Fernando Esperón, José Luiz Catão-Dias
Superficial mycoses are commonly reported in captive pinnipeds, usually maintained in wet and warm environments, favorable to fungal growth. Most superficial mycoses in pinnipeds have been described as difficult to treat; however, the majority of the reports come from past decades. Cutaneous lesions associated with opportunistic Fusarium sp. infections have been previously recognized in this taxon. We described the clinical signs, associated lesions and diagnosis (thermography, imprint cytology, histopathology, culture, electron microscopy, PCR) of a fusariosis case by Fusarium sp...
May 14, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29757665/comparison-of-compounded-generic-and-innovator-formulated-itraconazole-in-dogs-and-cats
#11
Janelle Renschler, Amanda Albers, Hanna Sinclair-Mackling, Lawrence Joseph Wheat
The triazole antifungal itraconazole may be cost prohibitive in brand name form; therefore, compounded and generic products are often used as alternatives. Itraconazole blood concentrations have not been studied in clinical patients receiving these formulations. Itraconazole bioassay was performed on serum/plasma from 95 dogs and 20 cats receiving itraconazole (compounded from bulk powder, generic pelletized, or brand name) for systemic mycosis treatment. Mean itraconazole concentration was lower in the compounded group (n = 42) as compared with the generic (n = 40) or brand name (n = 33) groups (0...
May 14, 2018: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/29747356/-research-on-the-surgery-treatment-and-etiology-of-fungal-endophthalmitis
#12
H Y Zhou, J J Ye, Y Y Chen, F T Dong
Objective: To evaluate the efficacy of vitrectomy and etiological diagnosis in the treatment of fungal endophthalmitis. Methods: A retrospective survey was done on the clinical manifestation, etiological diagnosis and treatment efficacy of 15 patients (15 eyes) who had been diagnosed with fungal endophthalmitis at the inpatient department of Peking Union Medical College Hospital during 2002-2015. A total of 15 eyes of 15 patients, 3 male and 12 female patients, were included in this study. The mean age of the patients was (45...
April 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29746162/antifungal-activity-of-essential-oils-against-azole-resistant-and-azole-susceptible-i-i-candida-glabrata-i-i-strains-vaginal-isolates
#13
Nadia Massa, Simone Cantamessa, Giorgia Novello, Elia Ranzato, Simona Martinotti, Matteo Pavan, Andrea Rocchetti, Graziella Berta, Elisa Gamalero, Elisa Bona
<i></i>Candida glabrata<i></i> is an opportunistic pathogen, associated with endocarditis, meningitis and disseminated disease and also with complicated vaginitis. Essential oils derived from aromatic plants are known in traditional medicine as antimicrobial agents and have antifungal properties. The aim of this work was to evaluate whether the twelve tested essential oils (tea tree, laurel, anise, basil, bergamot, lavender, mint, oregano, grapefruit, rosemary, winter savory and ginger) could have a transverse effect on <i></i>C...
May 10, 2018: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/29738315/diagnosis-and-treatment-of-histoplasmosis-in-solid-organ-transplant-patients
#14
Kiran Gajurel, Reshika Dhakal, Stan Deresinski
PURPOSE OF REVIEW: Unlike immunocompetent hosts, solid organ transplant (SOT) recipients with posttransplant histoplasmosis (PTH) often present with disseminated disease and have an attributable mortality of approximately 10%. In this review, we discuss currently available diagnostic tests and treatment strategies in PTH. RECENT FINDINGS: None of the available tests have a 100% diagnostic accuracy. Histoplasma antigen assays are the most sensitive commercially available tests...
May 5, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29735845/a-first-line-antiretroviral-therapy-resistant-hiv-patient-with-rhinoentomophthoromycosis
#15
Rachita Dhurat, Rajendra J Kothavade, Anand Kumar
The Conidiobolus coronatus-related rhinoentomophthoromycosis in immunocompetent and immunocompromised (HIV negative) individuals has been treated successfully with antifungal drugs. However, C. coronatus infections in first-line antiretroviral therapy (ART)-resistant (HIV infected) individuals particularly with rhinoentomophthoromycosis have not been reported previously. Here, we describe a case of itraconazole non-responding rhinoentomophthoromycosis in an HIV-infected patient with first-line antiretroviral (ART) drug resistance which was successfully managed through systematic diagnostic and therapeutic approaches in dermatologic setting...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29735828/histoplasmosis-in-non-endemic-north-western-part-of-india
#16
Atul K Patel, Ketan K Patel, Harsh Toshniwal, Swati Gohel, Arunaloke Chakrabarti
Purpose of Study: The western and North-Western parts of India are usually considered non-endemic for histoplasmosis. On the contrary, we observe histoplasmosis cases with relatively higher frequency from this region although the awareness and laboratory facility to diagnose the disease are not adequate. Hence, we planned the present retrospective study to compile the cases and to analyse different clinical parameters. Materials and Methods: Medical records of the patients diagnosed with histoplasmosis during January 2012-August 2017 at two infectious disease clinics of Ahmedabad were included in this study...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29735569/isavuconazole-concentration-in-real-world-practice-consistency-with-results-from-clinical-trials
#17
David Andes, Laura Kovanda, A Desai, Theresa Kitt, M Zhao, Thomas J Walsh
Clinical use of voriconazole, posaconazole, and itraconazole revealed the need for therapeutic drug monitoring (TDM) of plasma concentrations of these antifungal agents. This need for TDM was not evident from clinical trials of these drugs. In order to establish if this requirement also applies to isavuconazole, we examined the plasma concentrations of 283 samples receiving isavuconazole in clinical practice and compared the values to those from clinical trials. The concentration distributions from real-world use and clinical trials were nearly identical (>1 μg/mL in 90% of patients)...
May 7, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29724221/use-of-pinus-sylvestris-l-pinaceae-origanum-vulgare-l-lamiaceae-and-thymus-vulgaris-l-lamiaceae-essential-oils-and-their-main-components-to-enhance-itraconazole-activity-against-azole-susceptible-not-susceptible-cryptococcus-neoformans-strains
#18
Daniela Scalas, Narcisa Mandras, Janira Roana, Roberta Tardugno, Anna Maria Cuffini, Valeria Ghisetti, Stefania Benvenuti, Vivian Tullio
BACKGROUND: Cryptococcal infections, besides being a problem for immunocompromised patients, are occasionally being a problem for immunocompetent patients. In addition, the lower susceptibility of this yeast to azoles is a growing problem in health care. To date, there are very few molecules with any activity towards Cryptococcus neoformans, leading to heightened interest in finding new alternatives or adjuvants to conventional drugs for the treatment of mycosis caused by this yeast. Since the essential oils (EOs) are considered as a potential rich source of bioactive antimicrobial compounds, we evaluated the antifungal activity of Origanum vulgare (oregano), Pinus sylvestris (pine), and Thymus vulgaris (thyme red) EOs, and their components (α-pinene, carvacrol, thymol) compared with fluconazole, itraconazole, and voriconazole, against C...
May 3, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29723380/lobomycosis-a-therapeutic-challenge
#19
Marcelo Grossi Araújo, Nathalie Silva Cirilo, Soraya Neves Marques Barbosa Dos Santos, Claudemir Roberto Aguilar, Antonio Carlos Martins Guedes
Lobomycosis or lacaziosis is a chronic granulomatous fungal infection caused by Lacazia loboi. Most cases are restricted to tropical regions. Transmission is believed to occur through traumatic inoculation in the skin, mainly in exposed areas. It is characterized by keloid-like nodules. There are only a few hundred cases reported. The differential diagnoses include many skin conditions, and treatment is difficult. The reported case, initially diagnosed as keloid, proved to be refractory to surgical treatment alone...
March 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29707670/morphological-changes-and-induction-of-antifungal-resistance-in-aspergillus-fumigatus-due-to-different-co2-levels
#20
Sima Darabian, Sayed Jamal Hashemi, Sadegh Khodavaisy, Somayeh Sharifynia, Mohammad Kord, Maryam Akbari Dana, Farzad Aala, Sassan Rezaie
Background and Purpose: Aspergillosis is one of the most common opportunistic fungal infections in immunocompromised and neutropenic patients. Aspergillus fumigatus ( A. fumigatus ) is the most common causative agent of this infection. Due to variable CO2 concentrations that pathogens are exposed to during the infection process and to understand the role of CO2 , we examined the effects of various CO2 concentrations as one of the environmental factors on morphological changes and induction of antifungal resistance in A...
September 2017: Advances in Medical Mycology (Iran)
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