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https://www.readbyqxmd.com/read/29343419/successful-use-of-non-invasive-positive-pressure-ventilation-in-a-patient-with-the-severe-form-of-x-linked-myotubular-myopathy
#1
Kenji Inoue, Tomohiro Kumada, Ikuko Hiejima, Tatsuya Fujii
The severity of X-linked myotubular myopathy (XLMTM) ranges from mild to severe, depending on the level of ventilatory support required. Patients with the severe form of XLMTM usually die within the first year of life due to respiratory failure. Most survivors need tracheostomies, and there has only been one report about the use of non-invasive positive pressure ventilation (NPPV) in patients with the severe form of XLMTM because of the severity of the associated respiratory failure. We successfully applied NPPV with high-span positive inspiratory pressure (PIP) in a patient with the severe form of XLMTM, who also had secondary pectus excavatum...
January 14, 2018: Brain & Development
https://www.readbyqxmd.com/read/29340166/withdrawal-of-antihypertensive-therapy-in-people-with-dementia-feasibility-study
#2
Veronika van der Wardt, Jennifer K Burton, Simon Conroy, Tomas Welsh, Pip Logan, Jaspal Taggar, Lukasz Tanajewski, John Gladman
Background: This study explored the feasibility of a randomised controlled withdrawal trial of antihypertensive medication in normotensive people with dementia. Feasibility aspects included response, recruitment, exclusion and drop-out rates, suitability of outcome measures, acceptability of study procedures and an indicative economic evaluation for a randomised controlled trial. Methods: A cohort study attempting the withdrawal of antihypertensive drugs where appropriate and a feasibility study of home-based blood pressure monitoring, in people with dementia treated for hypertension, was undertaken...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29338771/regulation-of-aquaporins-in-plants-under-stress
#3
REVIEW
Ranganathan Kapilan, Maryam Vaziri, Janusz J Zwiazek
Aquaporins (AQP) are channel proteins belonging to the Major Intrinsic Protein (MIP) superfamily that play an important role in plant water relations. The main role of aquaporins in plants is transport of water and other small neutral molecules across cellular biological membranes. AQPs have remarkable features to provide an efficient and often, specific water flow and enable them to transport water into and out of the cells along the water potential gradient. Plant AQPs are classified into five main subfamilies including the plasma membrane intrinsic proteins (PIPs), tonoplast intrinsic proteins (TIPs), nodulin 26 like intrinsic proteins (NIPs), small basic intrinsic proteins (SIPs) and X intrinsic proteins (XIPs)...
January 16, 2018: Biological Research
https://www.readbyqxmd.com/read/29337869/aquaporin-expression-and-water-transport-pathways-inside-leaves-are-affected-by-nitrogen-supply-through-transpiration-in-rice-plants
#4
Lei Ding, Yingrui Li, Limin Gao, Zhifeng Lu, Min Wang, Ning Ling, Qirong Shen, Shiwei Guo
The photosynthetic rate increases under high-N supply, resulting in a large CO₂ transport conductance in mesophyll cells. It is less known that water movement is affected by nitrogen supply in leaves. This study investigated whether the expression of aquaporin and water transport were affected by low-N (0.7 mM) and high-N (7 mM) concentrations in the hydroponic culture of four rice varieties: (1) Shanyou 63 (SY63), a hybrid variant of the indica species; (2) Yangdao 6 (YD6), a variant of indica species; (3) Zhendao 11 (ZD11), a hybrid variant of japonica species; and (4) Jiuyou 418 (JY418), another hybrid of the japonica species...
January 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29335788/over-expression-of-a-grafting-responsive-gene-from-hickory-increases-abiotic-stress-tolerance-in-arabidopsis
#5
R M Saravana Kumar, Guocun Ji, Haipeng Guo, Liang Zhao, Bingsong Zheng
A grafting response gene CcPIP1;2 was cloned from hickory plant, further functional characterization of the gene for water transport activity and abiotic stress tolerances were carried out through heterologous expression in Xenopus and Arabidopsis. Plasma membrane intrinsic proteins (PIPs) are multifunctional channel proteins belonging to the membrane intrinsic protein (MIP) family. In this study, a grafting-responsive gene from hickory (CcPIP1;2) was cloned and functionally characterized. Application of non-selective water inhibitors (HgCl2 and phloretin) led to the death of grafted hickory plants at 30 days after grafting (DAG)...
January 15, 2018: Plant Cell Reports
https://www.readbyqxmd.com/read/29324820/incidence-and-prevalence-of-patellofemoral-pain-a-systematic-review-and-meta-analysis
#6
Benjamin E Smith, James Selfe, Damian Thacker, Paul Hendrick, Marcus Bateman, Fiona Moffatt, Michael Skovdal Rathleff, Toby O Smith, Pip Logan
BACKGROUND: Patellofemoral pain is considered one of the most common forms of knee pain, affecting adults, adolescents, and physically active populations. Inconsistencies in reported incidence and prevalence exist and in relation to the allocation of healthcare and research funding, there is a clear need to accurately understand the epidemiology of patellofemoral pain. METHODS: An electronic database search was conducted, as well as grey literature databases, from inception to June 2017...
2018: PloS One
https://www.readbyqxmd.com/read/29310373/a-rare-case-of-nonresterilized-reinforced-ett-obstruction-caused-by-a-structural-defect-a-case-report
#7
Sang Ho Kim, A Yeon Park, Ho Bum Cho, Jae Hwa Yoo, Sun Young Park, Ji Won Chung, Mun Gyu Kim
RATIONALE: Various factors can cause ventilatory failure after endotracheal tube (ETT) intubation, which is associated with increased patient morbidity and mortality. PATIENT CONCERNS: A 76-year-old woman who was diagnosed with a hemopericardium and suspicion of a major-vessel injury due to dislocation of the clavicular fracture fixation screw. DIAGNOSIS: Non-resterilized reinforced ETT obstruction caused by a structural defect. INTERVENTION: Endotracheal tube was exchanged...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29304952/clinical-effectiveness-of-a-systematic-pill-in-the-pocket-approach-for-the-management-of-paroxysmal-atrial-fibrillation
#8
Jason G Andrade, Jenny MacGillivray, Laurent Macle, Ren Jie Robert Yao, Matthew Bennett, Christopher B Fordyce, Nathaniel Hawkins, Andrew Krahn, John Jue, Krishnan Ramanathan, Teresa Tsang, Ken Gin, Marc W Deyell
BACKGROUND: For patients with symptomatic, sustained atrial fibrillation (AF), a "pill-in-the-pocket" antiarrhythmic drug (PIP-AAD) strategy has been proposed to reduce emergency department (ED) use. OBJECTIVE: To assess the clinical utility of a protocolled PIP-AAD approach within contemporary practice. METHODS: Consecutive patients who hemodynamically tolerated symptomatic, sustained AF were prospectively managed with the PIP-AAD strategy...
January 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29299872/coping-strategies-stress-and-support-needs-in-caregivers-of-children-with-mucopolysaccharidosis
#9
Amy Schadewald, Ericka Kimball, Li Ou
The mucopolysaccharidoses are a set of rare, inherited conditions that can have a catastrophic impact on those affected and their families. Because of the rarity of these disorders, little is known regarding the challenges faced by families of those affected and what coping mechanisms are commonly used. Coping is a way to manage demands that occur in one's environment or within oneself. Medical social workers historically have facilitated this process while providing support to patients who are responding to pressures of their diagnosis and the system...
January 4, 2018: JIMD Reports
https://www.readbyqxmd.com/read/29289433/comparison-between-several-ultrasound-hand-joint-scores-and-conventional-radiography-in-diagnosing-hand-osteoarthritis
#10
Priyanka Sivakumaran, Sidra Hussain, Coziana Ciurtin
This is the first study to investigate the usefulness of a standardized ultrasound (US) examination protocol in diagnosing hand osteoarthritis (OA). We conducted a cross-sectional study including 62 patients, ultimately diagnosed with hand OA based on imaging evidence of osteoarthritic changes with the particular distribution required for fulfilment of American College of Radiology diagnosis criteria. We compared a 32-joint US score (wrists, metacarpophalangeal [MCP], proximal interphalangeal [PIP] or distal interphalangeal [DIP] and carpometacarpal [CMC]-1 joints), with smaller, predefined joint scores, assessing 22 joints (wrists, MCPs and PIPs or PIPs, DIPs and CMC-1), 10 joints (MCP 2-3, PIP 2-3 and CMC-1 or PIP 2-3, DIP 2-3 and CMC-1) and 6 joints (DIP 2-3, CMC-1), respectively...
December 27, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29284286/10-years-eu-regulation-of-pediatric-medicines-impact-on-cardiovascular-drug-formulations
#11
Yasmin Thabet, Marta Slavkova, Jörg Breitkreutz
Child-appropriate drug formulations are mandatory for an efficient and safe drug therapy in children. Since the implementation of supportive legislations development of novel drug formulations has significantly been enforced despite the fact that children are a heterogeneous group of patients with varying needs according to age, maturation and disease. Areas covered: In this review, recent advances and current strategies are evaluated how to overcome the specific hurdles in pediatric drug development. For cardiovascular diseases as an example, EMA's decisions on pediatric investigation plans (PIPs) have been evaluated...
December 28, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/29282397/swan-neck-deformity-mimicking-claw-hand-caused-by-arthritis-in-leprosy
#12
Hendra Gunawan, Nia Srie Haryati, Oki Suwarsa
Swan neck deformity is a hyperextension of the proximal interphalangeal (PIP) joints and flexion of the distal interphalangeal (DIP) joints. Claw hand is a hyperextension of the metacarpal joints and flexion of the PIP joints, accompanied by reduced motor strength. A 23-year-old female, who was released from leprosy treatment, presented with a bend of the second to fifth fingers of both hands. There was hyperextension of the PIP joints and flexion of the DIP joints from the second to fifth fingers of both hands, thickening of the ulnar nerves, and hypoesthesia without motor impairment of the fourth and fifth fingers of both hands...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29281621/the-translesion-dna-polymerases-pol-%C3%AE-and-rev1-are-activated-independently-of-pcna-ubiquitination-upon-uv-radiation-in-mutants-of-dna-polymerase-%C3%AE
#13
Carine Tellier-Lebegue, Eléa Dizet, Emilie Ma, Xavier Veaute, Eric Coïc, Jean-Baptiste Charbonnier, Laurent Maloisel
Replicative DNA polymerases cannot insert efficiently nucleotides at sites of base lesions. This function is taken over by specialized translesion DNA synthesis (TLS) polymerases to allow DNA replication completion in the presence of DNA damage. In eukaryotes, Rad6- and Rad18-mediated PCNA ubiquitination at lysine 164 promotes recruitment of TLS polymerases, allowing cells to efficiently cope with DNA damage. However, several studies showed that TLS polymerases can be recruited also in the absence of PCNA ubiquitination...
December 27, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29281041/patterns-of-multi-morbidity-and-prediction-of-hospitalisation-and-all-cause-mortality-in-advanced-age
#14
Ruth O Teh, Oliver H Menzies, Martin J Connolly, Rob N Doughty, Tim J Wilkinson, Avinesh Pillai, Thomas Lumley, Cristin Ryan, Anna Rolleston, Joanna B Broad, Ngaire Kerse
Background: multi-morbidity is associated with poor outcomes and increased healthcare utilisation. We aim to identify multi-morbidity patterns and associations with potentially inappropriate prescribing (PIP), subsequent hospitalisation and mortality in octogenarians. Methods: life and Living in Advanced Age; a Cohort Study in New Zealand (LiLACS NZ) examined health outcomes of 421 Māori (indigenous to New Zealand), aged 80-90 and 516 non-Māori, aged 85 years in 2010...
December 21, 2017: Age and Ageing
https://www.readbyqxmd.com/read/29279728/a-comparison-of-er-yag-laser-with-photon-initiated-photoacoustic-streaming-nd-yag-laser-and-conventional-irrigation-on-the-eradication-of-root-dentinal-tubule-infection-by-enterococcus-faecalis-biofilms-a-scanning-electron-microscopy-study
#15
Burcu Ozses Ozkaya, Kamran Gulsahi, Mete Ungor, Julide Sedef Gocmen
This study evaluated the antimicrobial efficacy of Er:YAG laser activation with photon-initiated photoacoustic streaming (PIPS), Nd:YAG laser disinfection, and conventional irrigation on Enterococcus faecalis biofilms using scanning electron microscopy (SEM). Biofilms were grown on 110 root halves and divided into the following: Groups 1 and 2 (saline and 1% NaOCl with apical position of PIPS, resp.), Groups 3 and 4 (saline and 1% NaOCl with coronal position of PIPS, resp.), Groups 5 and 6 (Nd:YAG laser after saline and 1% NaOCl irrigation, resp...
2017: Scanning
https://www.readbyqxmd.com/read/29278770/identification-of-the-aqp-members-involved-in-abiotic-stress-responses-from-arabidopsis
#16
Zhi-Juan Feng, Sheng-Chun Xu, Na Liu, Gu-Wen Zhang, Qi-Zan Hu, Zhao-Shi Xu, Ya-Ming Gong
Aquaporins (AQPs) constitute a highly diverse family of water channel proteins that play crucial biological functions in plant growth and development and stress physiology. In Arabidopsis, 35 AQPs are classified into four subfamilies (PIPs, TIPs, NIPs and SIPs). However, knowledge about the roles of different subfamily AQPs remains limited. Here, we explored the chromosomal location, gene structure and expression patterns of all AQPs in different tissues or under different abiotic stresses based on available microarray data...
December 23, 2017: Gene
https://www.readbyqxmd.com/read/29276053/inter-observer-agreement-of-standard-joint-count-examination-and-disease-global-assessment-in-a-cohort-of-egyptian-rheumatoid-arthritis-patients
#17
Khaled El-Hadidi, Sherif M Gamal, Sahar Saad
OBJECTIVES: To assess the inter-observer agreement of standard joint count between experienced Rheumatology professor (Prof) and young Rheumatology fellow (candidate), and to compare disease global assessment between professor, young candidate and patients. METHODS: This study included one hundred rheumatoid arthritis patients. For all patients independent clinical evaluation was done by two rheumatologists (professor and candidate) for detection of tenderness in 28 joints and swelling in 26 joints...
December 21, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29274823/change-in-the-temporal-coordination-of-the-finger-joints-with-ulnar-nerve-block-during-different-power-grips-analyzed-with-a-sensor-glove
#18
N J Wachter, M Mentzel, C Häderer, G D Krischak, J Gülke
Ulnar nerve injuries can cause deficient hand movement patterns. Their assessment is important for diagnosis and rehabilitation in hand surgery cases. The purpose of this study was to quantify the changes in temporal coordination of the finger joints during different power grips with an ulnar nerve block by means of a sensor glove. In 21 healthy subjects, the onset and end of the active flexion of the 14 finger joints when gripping objects of different diameters was recorded by a sensor glove. The measurement was repeated after an ulnar nerve block was applied in a standardized setting...
December 20, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/29274418/extraction-purification-and-characterization-of-low-molecular-weight-proline-iminopeptidase-from-probiotic-l-plantarum-for-meat-tenderization
#19
Preeti Chanalia, Dimpi Gandhi, Pooja Attri, Suman Dhanda
Membrane bound proline iminopeptidase (PIP) from lactic acid bacteria (LAB) L. plantarum was extracted and purified using CM-sephadex, Sephadex G-100 and Q-sepharose column chromatography. PIP was purified with purification fold 7.13 and 33.5% yield. SDS-PAGE and MALDI-TOF revealed it as homodimer with molecular weight of 37.9 kDa and subunit of mass 18.9 kDa. Purified enzyme exhibited maximum activity at 45 °C and pH 7.0. Km and Vmax of purified PIP were 65 μM and 25.9 nm/min/ml respectively. Inhibition by PMSF confirmed it a serine protease...
December 20, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29273202/modes-of-interaction-of-pleckstrin-homology-domains-with-membranes-towards-a-computational-biochemistry-of-membrane-recognition
#20
Fiona B Naughton, Antreas C Kalli, Mark S P Sansom
Pleckstrin homology (PH) domains mediate protein-membrane interactions by binding to phosphatidylinositol phosphate (PIP) molecules. The structural and energetic basis of selective PH-PIP interactions is central to understanding many cellular processes, yet the molecular complexities of the PH-PIP interactions are largely unknown. Molecular dynamics (MD) simulations using a coarse-grained model enables estimation of free energy landscapes for the interactions of 12 different PH domains with membranes containing PIP2 or PIP3, allowing us to obtain a detailed molecular energetic understanding of the complexities of the interactions of the PH domains with PIP molecules in membranes...
December 19, 2017: Journal of Molecular Biology
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