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https://www.readbyqxmd.com/read/27921170/effect-of-photon-initiated-photoacoustic-streaming-passive-ultrasonic-and-sonic-irrigation-techniques-on-dentinal-tubule-penetration-of-irrigation-solution-a-confocal-microscopic-study
#1
Merve Akcay, Hakan Arslan, Merve Mese, Nazlı Durmus, Ismail Davut Capar
OBJECTIVES: The aim of this in vitro study was to evaluate the efficacy of different irrigation techniques including laser-activated irrigation using an erbium:yttrium-aluminum-garnet (Er:YAG) laser with a novel tip design (photon-induced photoacoustic streaming (PIPS)), Er:YAG laser with Preciso tip, sonic activation, and passive ultrasonic activation on the final irrigation solution penetration into dentinal tubules by using a laser scanning confocal microscope. MATERIAL AND METHODS: In this study, 65 extracted single-rooted human mandibular premolars were instrumented up to size 40 and randomly divided into 5 groups (n = 13) based on the activation technique of the final irrigation solution as follows: conventional irrigation (control group), sonic activation, passive ultrasonic activation, Er:YAG-PIPS tip activation, and Er:YAG-Preciso tip activation...
December 5, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27921093/evaluation-of-a-novel-semi-automated-ultrasound-system-for-the-detection-of-synovitis-a-prospective-study-involving-45-patients-with-rheumatoid-arthritis
#2
M Witt, J Frielinghausen, R Mueller, F Mueller, F Proft, H Schulze-Koops, M Grunke, D-A Clevert
Background: Arthrosonography has proven to be more sensitive and reliable for the detection of synovitis than clinical examination, but a comprehensive examination of small joints is time-consuming. The automated breast volume scanner (ABVS) has been developed to allow automatic and reproducible series of consecutive B-mode pictures of the female breast. Objectives: To analyze the comparability of ABVS and conventional manual ultrasonography (mUS) for the detection of synovitis in hands and feet of patients with rheumatoid arthritis (RA)...
November 2016: Ultrasound International Open
https://www.readbyqxmd.com/read/27921071/validation-of-automatic-joint-space-width-measurements-in-hand-radiographs-in-rheumatoid-arthritis
#3
Olga Schenk, Yinghe Huo, Koen L Vincken, Mart A van de Laar, Ina H H Kuper, Kees C H Slump, Floris P J G Lafeber, Hein J Bernelot Moens
Computerized methods promise quick, objective, and sensitive tools to quantify progression of radiological damage in rheumatoid arthritis (RA). Measurement of joint space width (JSW) in finger and wrist joints with these systems performed comparable to the Sharp-van der Heijde score (SHS). A next step toward clinical use, validation of precision and accuracy in hand joints with minimal damage, is described with a close scrutiny of sources of error. A recently developed system to measure metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints was validated in consecutive hand images of RA patients...
October 2016: Journal of Medical Imaging
https://www.readbyqxmd.com/read/27920046/resuscitation-of-infants-with-congenital-diaphragmatic-hernia
#4
Anthony O'Rourke-Potocki, Kamal Ali, Vadivelam Murthy, Anthony Milner, Anne Greenough
OBJECTIVE: To determine whether the respiratory response to resuscitation in infants with congenital diaphragmatic hernia (CDH) as measured by a respiratory function monitor differed between those who did and did not survive. DESIGN: Observational study. SETTING: Tertiary perinatal centre. PATIENTS: Thirty-eight infants born at 34 weeks of gestation or greater and diagnosed antenatally with a CDH. INTERVENTIONS: Expiratory tidal volume (VTe), peak inflation pressure (PIP) and end-tidal carbon dioxide level (ETCO2) were simultaneously recorded during resuscitation using a respiratory function monitor...
December 5, 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/27906959/pcna-dependent-cleavage-and-degradation-of-sde2-regulates-response-to-replication-stress
#5
Ukhyun Jo, Winson Cai, Jingming Wang, Yoojin Kwon, Alan D D'Andrea, Hyungjin Kim
Maintaining genomic integrity during DNA replication is essential for cellular survival and for preventing tumorigenesis. Proliferating cell nuclear antigen (PCNA) functions as a processivity factor for DNA replication, and posttranslational modification of PCNA plays a key role in coordinating DNA repair against replication-blocking lesions by providing a platform to recruit factors required for DNA repair and cell cycle control. Here, we identify human SDE2 as a new genome surveillance factor regulated by PCNA interaction...
December 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27897158/iqgap1-makes-pi-3-k-signalling-as-easy-as-pip-pip2-pip3
#6
Lucia E Rameh, Ashley M Mackey
Despite being one of the most studied signalling pathways, precisely how phospholipid synthesis is regulated in the phosphoinositide signalling cascade remains unclear. The scaffold protein IQGAP1 is now shown to orchestrate the assembly of a multi-enzyme complex that streamlines PtdIns(3,4,5)P3 synthesis to facilitate Akt activation in response to extracellular stimuli.
November 29, 2016: Nature Cell Biology
https://www.readbyqxmd.com/read/27882569/selective-reduction-in-the-expression-of-ugts-and-sults-a-novel-mechanism-by-which-piperine-enhances-the-bioavailability-of-curcumin-in-rat
#7
Xiaohui Zeng, Dake Cai, Qiaohuang Zeng, Zhao Chen, Guoping Zhong, Juncheng Zhuo, Haining Gan, Xuejun Huang, Ziming Zhao, Nan Yao, Dane Huang, Chengzhe Zhang, Dongmei Sun, Yuxing Chen
Curcumin (CUR) is known to exert numerous health-promoting effects in pharmacological studies, but its low-bioavailability hinders the development of CUR as a feasible therapeutic agent. Piperine (PIP) has been reported to enhance the bioavailability of CUR, but the underlying mechanism remains poorly understood. In an attempt to find the mechanism by which PIP enhances the bioavailability of CUR, dosage ratio (CUR: PIP) and PIP pre-treatment are hypothesized as key factors for bioavailability improvement in this combination...
November 23, 2016: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/27877186/selection-of-reference-genes-for-rt-qpcr-analysis-in-coccinella-septempunctata-to-assess-un-intended-effects-of-rnai-transgenic-plants
#8
Chunxiao Yang, Evan L Preisser, Hongjun Zhang, Yong Liu, Liangying Dai, Huipeng Pan, Xuguo Zhou
The development of genetically engineered plants that employ RNA interference (RNAi) to suppress invertebrate pests opens up new avenues for insect control. While this biotechnology shows tremendous promise, the potential for both non-target and off-target impacts, which likely manifest via altered mRNA expression in the exposed organisms, remains a major concern. One powerful tool for the analysis of these un-intended effects is reverse transcriptase-quantitative polymerase chain reaction, a technique for quantifying gene expression using a suite of reference genes for normalization...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27865999/approaches-to-improve-metabolic-stability-of-a-statine-based-grp-receptor-antagonist
#9
Ilinca Popp, Luigi Del Pozzo, Beatrice Waser, Jean Claude Reubi, Philipp T Meyer, Helmut R Maecke, Eleni Gourni
: The bombesin receptor family, in particular the gastrin-releasing peptide receptor (GRPr), is an attractive target in the field of nuclear oncology due to the high density of these receptors on the cell surface of several human tumors. The successful clinical implementation of (64)Cu-CB-TE2A-AR06, (68)Ga-RM2 and (68)Ga-NODAGA-MJ9, prompted us to continue the development of GRPr-antagonists. The aim of the present study was to assess if N-terminal modulations of the statine-based GRPr-antagonist influence the binding affinity, the pharmacokinetic performance and the in vivo metabolic stability...
November 4, 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/27859220/farmland-biodiversity-and-agricultural-management-on-237-farms-in-13-european-and-two-african-regions
#10
Gisela Lüscher, Youssef Ammari, Aljona Andriets, Siyka Angelova, Michaela Arndorfer, Debra Bailey, Katalin Balázs, Marion Bogers, Robert G H Bunce, Jean-Philippe Choisis, Peter Dennis, Mario Díaz, Tetyana Dyman, Sebastian Eiter, Wendy Fjellstad, Mariecia Fraser, Jürgen K Friedel, Salah Garchi, Ilse R Geijzendorffer, Tiziano Gomiero, Guillermo González-Bornay, Yana Guteva, Felix Herzog, Philippe Jeanneret, Rob H G Jongman, Max Kainz, Norman Kwikiriza, María Lourdes López Díaz, Gerardo Moreno, Pip Nicholas-Davies, Charles Nkwiine, Julius Opio, Maurizio G Paoletti, László Podmaniczky, Philippe Pointereau, Fernando Pulido, Jean-Pierre Sarthou, Manuel K Schneider, Tahar Sghaier, Norman Siebrecht, Siyka Stoyanova, Sebastian Wolfrum, Sergiy Yashchenko, Harald Albrecht, András Báldi, Márta Belényesi, Jacinto Benhadi-Marin, Theo Blick, Serge Buholzer, Csaba Centeri, Norma Choisis, Gérard Cuendet, Hendrika J De Lange, Sylvain Déjean, Christo Deltshev, Darío J Díaz Cosín, Wenche Dramstad, Zoltán Elek, Gunnar Engan, Konstantin Evtushenko, Eszter Falusi, Oliver-D Finch, Thomas Frank, Federico Gavinelli, David Genoud, Phillipa K Gillingham, Viktor Grónás, Mónica Gutiérrez, Werner Häusler, Xaver Heer, Thomas Hübner, Marco Isaia, Gergely Jerkovich, Juan B Jesus, Esezah Kakudidi, Eszter Kelemen, Nóra Koncz, Eszter Kovacs, Anikó Kovács-Hostyánszki, Luisa Last, Toshko Ljubomirov, Klaus Mandery, Josef Mayr, Atle Mjelde, Christoph Muster, Juri Nascimbene, Johann Neumayer, Frode Ødegaard, Francisco Javier Ortiz Sánchez, Marie-Louise Oschatz, Susanne Papaja-Hülsbergen, Mauro Paschetta, Mark Pavett, Céline Pelosi, Károly Penksza, Reidun Pommeresche, Victor Popov, Volodymyr Radchenko, Nina Richner, Susanne Riedel, John Scullion, Daniele Sommaggio, Ottó Szalkovszki, Erich Szerencsits, Dolores Trigo, Jim Vale, Ruud van Kats, Angel Vasilev, Andrew E Whittington, Jerylee Wilkes-Allemann, Tommaso Zanetti
Farmland is a major land cover type in Europe and Africa and provides habitat for numerous species. The severe decline in farmland biodiversity of the last decades has been attributed to changes in farming practices, and organic and low-input farming are assumed to mitigate detrimental effects of agricultural intensification on biodiversity. Since the farm enterprise is the primary unit of agricultural decision making, management-related effects at the field scale need to be assessed at the farm level. Therefore, in this study, data were collected on habitat characteristics, vascular plant, earthworm, spider, and bee communities and on the corresponding agricultural management in 237 farms in 13 European and two African regions...
June 2016: Ecology
https://www.readbyqxmd.com/read/27846749/synovitis-of-sternoclavicular-and-peripheral-joints-can-be-detected-by-ultrasound-in-patients-with-sapho-syndrome
#11
Masataka Umeda, Shin-Ya Kawashiri, Ayako Nishino, Tomohiro Koga, Kunihiro Ichinose, Toru Michitsuji, Toshimasa Shimizu, Shoichi Fukui, Yoshikazu Nakashima, Yasuko Hirai, Naoki Iwamoto, Toshiyuki Aramaki, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Yukitaka Ueki, Atsushi Kawakami
OBJECTIVES: To determine the prevalence of ultrasonographic abnormalities of sternoclavicular joints (SCJ) and peripheral joints (PJ) in patients with synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome. METHODS: Thirteen patients with SAPHO syndrome who fulfilled diagnostic criteria proposed by Kahn for SAPHO syndrome 2003 and 13 healthy individuals age- and sex-matched were enrolled. Synovitis, defined by synovial hypertrophy with power Doppler (PD) signals, of the SCJ and the PJ including wrist, MCP, PIP and the other symptomatic joints were evaluated by ultrasound (US)...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27836926/new-horizons-the-management-of-hypertension-in-people-with-dementia
#12
REVIEW
Jennifer Kirsty Harrison, Veronika Van Der Wardt, Simon Paul Conroy, David J Stott, Tom Dening, Adam Lee Gordon, Pip Logan, Tomas James Welsh, Jaspal Taggar, Rowan Harwood, John R F Gladman
The optimal management of hypertension in people with dementia is uncertain. This review explores if people with dementia experience greater adverse effects from antihypertensive medications, if cognitive function is protected or worsened by controlling blood pressure (BP) and if there are subgroups of people with dementia for whom antihypertensive therapy is more likely to be harmful. Robust evidence is scant, trials of antihypertensive medications have generally excluded those with dementia. Observational data show changes in risk association over the life course, with high BP being a risk factor for cognitive decline in mid-life, while low BP is predictive in later life...
November 2016: Age and Ageing
https://www.readbyqxmd.com/read/27836388/plastic-in-patient-study-prospective-audit-of-adherence-to-peripheral-intravenous-cannula-monitoring-and-documentation-guidelines-with-the-aim-of-reducing-future-rates-of-intravenous-cannula-related-complications
#13
Lokesh Yagnik, Angela Graves, Ken Thong
BACKGROUND: Peripheral intravenous cannula (PIVC) insertion is a universal intervention for inpatients and is associated with multiple complications. Effective, simple, reproducible interventions specific to PIVC complication prevention are few and often extrapolated from central venous catheter complication prevention strategies. The objective of this study is to improve compliance with documentation and monitoring PIVC guidelines in the medical ward of a secondary care center. METHODS: This study is a prospective run-in audit of adherence to PIVC documentation and monitoring guidelines between the dates of August 30-November 14, 2014, with data recollection from December 25, 2014-January 30, 2015, after intervention implementation...
November 8, 2016: American Journal of Infection Control
https://www.readbyqxmd.com/read/27826050/structural-basis-of-phosphatidyl-myo-inositol-mannosides-biosynthesis-in-mycobacteria
#14
REVIEW
Enea Sancho-Vaello, David Albesa-Jové, Ane Rodrigo-Unzueta, Marcelo E Guerin
Phosphatidyl-myo-inositol mannosides (PIMs) are glycolipids of unique chemical structure found in the inner and outer membranes of the cell envelope of all Mycobacterium species. The PIM family of glycolipids comprises phosphatidyl-myo-inositol mono-, di-, tri-, tetra-, penta-, and hexamannosides with different degrees of acylation. PIMs are considered not only essential structural components of the cell envelope but also the precursors of lipomannan and lipoarabinomannan, two major lipoglycans implicated in host-pathogen interactions...
November 5, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27825603/experimental-study-of-the-optimal-angle-for-arthrodesis-of-fingers-based-on-kinematic-analysis-with-tip-pinch-manipulation
#15
Paul Arauz, Sue Ann Sisto, Imin Kao
To evaluate the appropriate angle for arthrodesis of the index finger proximal interphalangeal (PIP) joint, the functional range of motion (ROM) of the joints and manipulabilities at three selected tip-pinch manipulation postures of the finger were studied experimentally under imposed PIP joint arthrodesis angles. A kinematic model of the index finger was used in experiments which involved three postures. Experiments were conducted using seven healthy subjects in tip-pinch manipulation tasks to obtain the measurements of finger motions under imposed angles of joint constraint, including the functional ROM of the joints and the three criteria of kinematic manipulability...
November 3, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27821437/curcumin-piperine-and-capsaicin-a-comparative-study-of-spice-mediated-inhibition-of-human-cytochrome-p450-isozyme-activities
#16
Suhaili Shamsi, Huong Tran, Renee Siok Jin Tan, Zee Jian Tan, Lee Yong Lim
Inhibition of the cytochrome P450 (CYP) enzymes has been shown to enhance the metabolism of drugs that are CYP substrates, and to consequently alter their pharmacokinetic profiles. Curcumin (CUR), piperine (PIP) and capsaicin (CAP) are spice components (SC) that inhibit the activities of a range of CYP enzymes, but the selection of which SC to be prioritised for further development as adjuvant will depend on the ranking order of inhibitory potential of the SCs on specific CYP isozymes. This paper aimed to utilise common human recombinant enzyme platforms to provide a comparative evaluation of the inhibitory activities of CUR, PIP and CAP on the principal drug-metabolising CYP enzymes...
November 7, 2016: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/27819060/the-hidden-conundrum-of-phosphoinositide-signaling-in-cancer
#17
Narendra Thapa, Xiaojun Tan, Suyong Choi, Paul F Lambert, Alan C Rapraeger, Richard A Anderson
Phosphoinositide 3-kinase (PI3K) generation of PI(3,4,5)P3 from PI(4,5)P2 and the subsequent activation of Akt and its downstream signaling cascades (e.g. mTORC1) dominates the landscape of phosphoinositide signaling axis in cancer research. However, PI(4,5)P2 is breaking its boundary as merely a substrate for PI3K and phospholipase C (PLC), and is now an established lipid messenger pivotal for different cellular events in cancer. Here, we review the phosphoinositide signaling axis in cancer, giving due weight to PI(4,5)P2 and its generating enzymes, the phosphatidylinositol phosphate (PIP) kinases (PIPKs)...
July 2016: Trends in Cancer
https://www.readbyqxmd.com/read/27810868/introducing-the-postsecondary-instructional-practices-survey-pips-a-concise-interdisciplinary-and-easy-to-score-survey
#18
Emily M Walter, Charles R Henderson, Andrea L Beach, Cody T Williams
Researchers, administrators, and policy makers need valid and reliable information about teaching practices. The Postsecondary Instructional Practices Survey (PIPS) is designed to measure the instructional practices of postsecondary instructors from any discipline. The PIPS has 24 instructional practice statements and nine demographic questions. Users calculate PIPS scores by an intuitive proportion-based scoring convention. Factor analyses from 72 departments at four institutions (N = 891) support a 2- or 5-factor solution for the PIPS; both models include all 24 instructional practice items and have good model fit statistics...
2016: CBE Life Sciences Education
https://www.readbyqxmd.com/read/27810594/synthesis-of-coumaperine-derivatives-their-nf-%C3%AE%C2%BAb-inhibitory-effect-inhibition-of-cell-migration-and-their-cytotoxic-activity
#19
Natarajan Nandakumar, Subramani Muthuraman, Pushparathinam Gopinath, Pattusamy Nithya, Jacob Gopas, Rajendran Saravana Kumar
Coumaperine (an amide alkaloid, present in white piper) and its derivatives were synthesized and investigated for their cytotoxicity against L428 and A549 cells and their NF-κB inhibitory activity. It was found that the coumaperine derivatives CP-9 and CP-38 suppress NF-κB subunits p50 and p65 in nuclear fractions by western blot and by NF-κB luciferase reporter gene assay in a dose dependent manner. Confirmation of these results was obtained by confocal microscopy. CP-9, CP-32 and CP-38 also exhibited dose dependent cell cytotoxicity in a L428 cells expressing constitutively active NF-κB and in A549 cells, with an IC50 value of 43...
October 22, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27808307/calculations-of-the-active-mode-and-energetic-barrier-to-electron-attachment-to-cf3-and-comparison-with-kinetic-modeling-of-experimental-results
#20
Huixian Han, Benjamin Alday, Nicholas S Shuman, Justin P Wiens, Jürgen Troe, Albert A Viggiano, Hua Guo
To provide a deeper understanding of the kinetics of electron attachment to CF3, the six-dimensional potential energy surfaces of both CF3 and CF3(-) were developed by fitting ∼3000 ab initio points per surface at the AE-CCSD(T)-F12a/AVTZ level using the permutation invariant polynomial-neural network (PIP-NN) approach. The fitted potential energy surfaces for CF3 and CF3(-) had root mean square fitting errors relative to the ab initio calculations of 1.2 and 1.8 cm(-1), respectively. The main active mode for the crossing between the two potential energy surfaces was identified as the umbrella bending mode of CF3 in C3v symmetry...
November 16, 2016: Physical Chemistry Chemical Physics: PCCP
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