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https://www.readbyqxmd.com/read/29147805/can-clinical-practice-indicator-relating-to-long-acting-benzodiazepine-use-in-the-elderly-be-easily-generated-in-a-hospital-setting
#1
Badria Kadri, Antonio Teixeira, Christelle Duteil, Annabelle Tan, Hélène Barreteau, Christophe Segouin, Pénélope Troude
BACKGROUND: To improve the appropriate use of long-acting benzodiazepine (la.bzd) prescriptions in the elderly, the Haute Autorité de Santé (HAS) has developed clinical practice indicators (CPI). The alert indicator (AI) evaluates the prevalence of la.bzd prescription among older people. The mastering indicator (MI) corresponds to the prevalence of elderly with a justified, i.e., appropriate, la.bzd prescription among all the elderly with la.bzd prescriptions. OBJECTIVE: The objective of this study was to test the feasibility of routine generation of CPI regarding la...
November 16, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29146864/acute-hypoxia-reoxygenation-and-vascular-oxygen-sensing-in-the-chicken-embryo
#2
Riazuddin Mohammed, Carlos E Salinas, Dino A Giussani, Carlos E Blanco, Angel L Cogolludo, Eduardo Villamor
Fetal/perinatal hypoxia is one of the most common causes of perinatal morbidity and mortality and is frequently accompannied by vascular dysfunction. However, the mechanisms involved have not been fully delineated. We hypothesized that exposure to acute hypoxia-reoxygenation induces alterations in vascular O2 sensing/signaling as well as in endothelial function in the chicken embryo pulmonary artery (PA), mesenteric artery (MA), femoral artery (FA), and ductus arteriosus (DA). Noninternally pipped 19-day embryos were exposed to 10% O2 for 30 min followed by reoxygenation with 21% O2 or 80% O2 Another group was constantly maintained at 21% O2 or at 21% O2 for 30 min and then exposed to 80% O2 Following treatment, responses of isolated blood vessels to hypoxia as well as endothelium-dependent (acetylcholine) and -independent (sodium nitroprusside and forskolin) relaxation were investigated in a wire myograph...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29145919/potentially-inappropriate-prescription-of-antidepressants-in-old-people-characteristics-associated-factors-and-impact-on-mortality
#3
Anne Hiance-Delahaye, Florence Muller de Schongor, Laurent Lechowski, Laurent Teillet, Jean-Jacques Arvieu, Jean-Marie Robine, Joël Ankri, Marie Herr
BACKGROUND: The increasing use of antidepressants (ADs) has raised concerns about their inappropriate use in old people. OBJECTIVE: To examine the prevalence of potentially inappropriate prescribing (PIP) of ADs, their associated factors, and their impact on mortality in a sample of old people in France. METHODS: The analysis used data from the SIPAF study, a cross-sectional study consisting of 2,350 people aged ≥ 70 years. Trained nurses interviewed participants at home between 2008 and 2010...
November 17, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29140987/dating-the-beginning-of-the-roman-viticultural-model-in-the-western-mediterranean-the-case-study-of-chianti-central-italy
#4
Riccardo Aversano, Boris Basile, Mauro Paolo Buonincontri, Francesca Carucci, Domenico Carputo, Luigi Frusciante, Gaetano Di Pasquale
Although domestication of the grapevine (Vitis vinifera L.) has been extensively documented, the history of genotype selection and evolution of vineyard management remain relatively neglected fields of study. The find of 454 waterlogged grapevine pips from a well-dated Etrusco-Roman site in the Chianti district (Tuscany, Central Italy) is an extraordinary chance to gain insights into the progress of viticulture occurring in a key historical period in one of the world's most famous wine regions. The molecular and geometrical analyses of grape seeds showed (a) the presence in the site of different grapevine individuals and (b) a sudden increase in pip size, occurring at around 200 BC, whic explainable by the selection and introduction of new varieties...
2017: PloS One
https://www.readbyqxmd.com/read/29133958/reductions-in-root-hydraulic-conductivity-in-response-to-clay-soil-and-treated-waste-water-are-related-to-pips-down-regulation-in-citrus
#5
Indira Paudel, Shabtai Cohen, Lyudmila Shlizerman, Amit K Jaiswal, Avi Shaviv, Avi Sadka
Citrus hydraulic physiology and PIP transcript levels were characterized in heavy (clay) and light (sandy loam) soils with and without treated waste water (TWW) irrigation after a summer irrigation season and at the end of a winter rainy season recovery period. Consistent reductions in clay soils compared to sandy loam were found for fresh water (FW) and TWW irrigation, respectively, in root water uptake, as well as in hydraulic conductivity of whole plant (Ks plant), stem (Ks stem) and root (Ks root). Transcript levels of most PIPs down-regulated following TWW irrigation in both soils, but relative gene expression of three PIPs was significantly higher in summer for sandy soil and FW than for clay soil and TWW; their mRNA levels was significantly correlated to Ks root...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29133241/in-silico-comparisons-between-natural-inhibitors-of-abcb1-p-glycoprotein-to-overcome-doxorubicin-resistance-in-the-nci-adr-res-cell-line
#6
Mohamed A Morsy, Azza A K El-Sheikh, Ahmed R N Ibrahim, Mohammed A Khedr, Abdulla Y Al-Taher
To investigate compound-protein binding mode and molecular dynamic simulation of P-glycoprotein (P-gp), in silico studies were performed to compare 12 naturally occurring compounds using two softwares. The net results showed that piperine (PIP) had the best binding affinity. In vitro studies on DOX-resistant NCI/ADR-RES cells, known to express P-gp, showed that, dose-dependently, PIP significantly increased intracellular accumulation of rhodamine-123 and had cytotoxic effects accessed by MTT assay. In addition, PIP at 25 and 50μM significantly potentiated DOX-induced cytotoxicity on the same cell line...
November 10, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29127515/correction-to-insertion-of-the-ascension-pyrocarbon-pip-total-joint-in-152-human-cadaver-fingers-analysis-of-implant-positions-and-malpositions
#7
Bernd Hohendorff, W Zhang, K J Burkhart, L P Müller, C Ries
In the experimental study the distal component of the Ascension PyroCarbon proximal interphalangeal total joint prosthesis was implanted 180° rotated. Figures 2-5 show the implant malpositions. The methods, results, and conclusion of the study were not affected by this.
November 10, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29123641/systematically-linking-transmart-galaxy-and-ega-for-reusing-human-translational-research-data
#8
Chao Zhang, Jochem Bijlard, Christine Staiger, Serena Scollen, David van Enckevort, Youri Hoogstrate, Alexander Senf, Saskia Hiltemann, Susanna Repo, Wibo Pipping, Mariska Bierkens, Stefan Payralbe, Bas Stringer, Jaap Heringa, Andrew Stubbs, Luiz Olavo Bonino Da Silva Santos, Jeroen Belien, Ward Weistra, Rita Azevedo, Kees van Bochove, Gerrit Meijer, Jan-Willem Boiten, Jordi Rambla, Remond Fijneman, J Dylan Spalding, Sanne Abeln
The availability of high-throughput molecular profiling techniques has provided more accurate and informative data for regular clinical studies. Nevertheless, complex computational workflows are required to interpret these data. Over the past years, the data volume has been growing explosively, requiring robust human data management to organise and integrate the data efficiently. For this reason, we set up an ELIXIR implementation study, together with the Translational research IT (TraIT) programme, to design a data ecosystem that is able to link raw and interpreted data...
2017: F1000Research
https://www.readbyqxmd.com/read/29121165/perf-an-exhaustive-algorithm-for-ultra-fast-and-efficient-identification-of-microsatellites-from-large-dna-sequences
#9
Akshay Kumar Avvaru, Divya Tej Sowpati, Rakesh Kumar Mishra
Motivation: Microsatellites or Simple Sequence Repeats (SSRs) are short tandem repeats of DNA motifs present in all genomes. They have long been used for a variety of purposes in the areas of population genetics, genotyping, marker-assisted selection, and forensics. Numerous studies have highlighted their functional roles in genome organization and gene regulation. Though several tools are currently available to identify SSRs from genomic sequences, they have significant limitations. Results: We present a novel algorithm called PERF for extremely fast and comprehensive identification of microsatellites from DNA sequences of any size...
November 7, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29119492/a-numerical-study-on-the-effect-of-various-combustion-bowl-parameters-on-the-performance-combustion-and-emission-behavior-on-a-single-cylinder-diesel-engine
#10
Dhinesh Balasubramanian, Sabari Rajan Sokkalingam Arumugam, Lingesan Subramani, Isaac JoshuaRamesh Lalvani Joshua Stephen Chellakumar, Annamalai Mani
A numerical study was carried out to study the effect of various combustion bowl parameters on the performance behavior, combustion characteristics, and emission magnitude on a single cylinder diesel engine. A base combustion bowl and 11 different combustion bowls were created by varying the aspect ratio, reentrancy ratio, and bore to bowl ratio. The study was carried out at engine rated speed and a full throttle performance condition, without altering the compression ratio. The results revealed that the combustion bowl parameters could have a huge impact on the performance behavior, combustion characteristics, and emission magnitude of the engine...
November 8, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29117832/prevalence-of-absence-of-palmaris-longus-and-its-association-with-gender-hand-dominance-and-absence-of-fds-tendon-to-little-finger-among-malay-population
#11
Mei Wen Yong, Nabihah Yusof, Lekhraj Rampal, Manohar Arumugam
BACKGROUND: Palmaris Longus is being widely used in reconstructive, plastic and cosmetic surgeries due to its long tendon. It is the most readily available source for tendon grafting. The objective of this study was to determine the prevalence of absence of Palmaris Longus and its association with gender, hand dominance and absence of FDS (flexor digitorum superficialis) tendon to little finger among Malay population. METHODS: An analytical cross sectional study design was used and a self-administered proforma was distributed for data collection...
December 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/29116449/comparative-pulvinar-organization-across-different-primate-species
#12
Ricardo Gattass, Juliana G M Soares, Bruss Lima
In this chapter, we compare the pattern of pulvinar immunohistochemical staining for the calcium-binding proteins calbindin and parvalbumin and for the neurofilament protein SMI-32 in macaque, capuchin, and squirrel monkeys. This group of New and Old World primates shares five similar pulvinar subdivisions: PIP, PIM, PIC, PIL, and PILS. In the Old World macaque monkey, the inferior-lateral pulvinar can be subdivided into the P1 and P2 fields based on its connectivity with visual area V1. On the other hand, only the P1 field and no P2 was found in the New World capuchin monkey...
2018: Advances in Anatomy, Embryology, and Cell Biology
https://www.readbyqxmd.com/read/29112820/daedophamide-a-cytotoxic-cyclodepsipeptide-from-a-daedalopelta-sp-sponge-collected-in-indonesia
#13
Carlos Urda, Rogelio Fernández, Jaime Rodríguez, Marta Pérez, Carlos Jiménez, Carmen Cuevas
A new cyclodepsipeptide, daedophamide (1), has been isolated from a Daedalopelta sp. marine sponge collected from Alor Island (Indonesia). The planar structure of 1 was assigned on the basis of extensive 1D and 2D NMR spectroscopy and mass spectrometry. Daedophamide (1) contains 11 amino acid residues and an amide-linked 3-hydroxy-2,4,6,8-tetramethylnonanoic acid (Htemna). The amino acid constituents were identified as l-Leu, N-Me-l-Gln, d-Arg, d-Asp, d-allo-Thr, l-Pip, d-Ala, d-Ser, 3,4-dimethyl-Gln, O-MeThr, and 4-amino-7-guanidino-2,3-dihydroxyheptanoic acid (Agdha)...
November 7, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29109758/antitumor-and-immunomodulating-activities-of-six-phellinus-igniarius-polysaccharides-of-different-origins
#14
Wenwen Gao, Wangdi Wang, Wenjian Sun, Mingfang Wang, Na Zhang, Shuwen Yu
The aim of the current study was to compare the antitumor efficiency of Phellinus igniarius polysaccharides (PIP) from six different origins and preliminarily investigate its potential mechanisms. PIP was extracted using the microwave extraction method. The corresponding in vivo antitumor efficacy was assessed in Kunming mice bearing H22 tumors and Gansu PIP (GPIP) was identified to have a significantly higher antitumor efficacy compared with the control group (P<0.05), while no significant difference was observed following treatment with PIP from different origins (P>0...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29108665/evaluation-of-a-polyvalent-foot-and-mouth-disease-virus-vaccine-containing-a-saudi-95-against-field-challenge-on-large-scale-dairy-farms-in-saudi-arabia-with-the-emerging-a-asia-g-vii-viral-lineage
#15
Nicholas A Lyons, Anna B Ludi, Ginette Wilsden, Pip Hamblin, Ibrahim Ahmed Qasim, Simon Gubbins, Donald P King
In 2015, foot-and-mouth disease (FMD) viruses of the A/ASIA/G-VII lineage emerged from the Indian sub-continent to cause outbreaks in the Middle and Near East. A factor which has been proposed to have contributed to the rapid spread of this lineage is the poor in vitro vaccine-match of field isolates to vaccine strains that are commonly used in the region. This study used data from outbreaks on four large-scale dairy farms using routine vaccination in Saudi Arabia, to evaluate the impact of vaccination and learn how to manage outbreaks more effectively in this setting...
November 3, 2017: Vaccine
https://www.readbyqxmd.com/read/29107890/potentially-inappropriate-prescribing-according-to-stopp-2-criteria-among-patients-discharged-from-internal-medicine-prevalence-involved-drugs-and-economic-cost
#16
Alfredo José Pardo-Cabello, Victoria Manzano-Gamero, Mónica Zamora-Pasadas, Francisco Gutiérrez-Cabello, David Esteva-Fernández, Juan de Dios Luna-Del Castillo, Juan Jiménez-Alonso
AIM: This study aims to determine the prevalence of potentially inappropriate prescribing (PIP) among patients discharged from Internal Medicine, the drugs and factors associated and economic cost of PIP. METHODS: This retrospective cross-sectional, single-center study included participants aged ≥65 years consecutively discharged from the Internal Medicine Unit in a tertiary hospital of Southern Spain. PIP was defined by the Screening Tool for Older Persons Prescriptions (STOPP-2) criteria version 2 (2015 update)...
November 2, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29105590/swan-neck-deformity-due-to-chronic-radial-collateral-ligament-injury-of-the-little-finger-proximal-interphalangeal-joint
#17
Yoshitaka Hamada, Hiroaki Takai, Ryousuke Satoh, Naohito Hibino, Yukiko Ueda, Yoshitaka Minamikawa
We present seven cases of a relatively rare swan neck deformity resulting from chronic radial collateral ligament (RCL) injury of the proximal interphalangeal (PIP) joint in the little finger. All patients were middle-aged women (mean 51 years old, range 42-55), and the duration between the initial injury and surgery was 20 years (range 5-40). The chief complaint was painful snapping of the PIP joint. All patients had hyperextension and ulnar deviation of the PIP joint with mobile swan neck deformities that had not improved with conservative treatment...
January 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29105400/effects-of-klf4-and-c-myc-knockdown-on-pluripotency-maintenance-in-porcine-induced-pluripotent-stem-cell
#18
Yu-Jing Liao, Yi-Shiou Chen, Ja-Xin Lee, Lih-Ren Chen, Jenn-Rong Yang
OBJECTIVES: The importance of Oct4 and Sox2 in maintaining pluripotency and self-renewal is well-understood, but the functions of Klf4 and c-Myc has not been fully investigated. In the present study, we attempted to determine the roles of Klf4 and c-Myc on pluripotency maintenance of porcine induced pluripotent stem (piPS) cells. MATERIALS AND METHODS: In this experimental study, we performed short hairpin RNA (shRNA) to knock down the Klf4 and c-Myc functions of piPS cells and examined pluripotency markers and teratoma formation to evaluate piPS cell pluripotency...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29100049/pip-ing-lipids-on-membranes-pten-takes-the-cake
#19
Archna Ravi, Brooke M Emerling
In this issue of Molecular Cell, Malek et al. (2017) describe a novel HPLC-MS method permitting separation of PI(3,4)P2 and PI(4,5)P2, a technical issue hindering the phosphoinositide signaling field. They use this method to uncover a new target and critical role for PTEN in cancer.
November 2, 2017: Molecular Cell
https://www.readbyqxmd.com/read/29097029/conformational-properties-of-ascydiacyclamide-analogues-with-cyclic-%C3%AE-amino-acids-instead-of-oxazoline-residues
#20
Akiko Asano, Shohei Numata, Takeshi Yamada, Katsuhiko Minoura, Mitsunobu Doi
Ascidiacyclamide [ASC, cyclo(-Ile-oxazoline-d-Val-thiazole-)2] is a cyclic octapeptide isolated from tunicates. We designed ASC analogues [cyclo(-Ile-Xxx-d-Val-thiazole-)2] in which Pro or a homologue was substituted for oxazoline: [Pro]ASC (Xxx: proline), [Aze]ASC (Xxx: (S)-Azetidine-2-carboxylic acid), [Pip]ASC (Xxx: (S)-Piperidine-2-carboxylic acid) and [ΔPro]ASC (Xxx: (S)-3-pyrroline-2-carboxylic acid) to explore their potential to serve as substitutes for the oxazoline ring. The conformations of these analogues were examined using X-ray diffraction, (1)H NMR and CD spectroscopy...
October 26, 2017: Bioorganic & Medicinal Chemistry
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