keyword
https://read.qxmd.com/read/38547097/piperine-alleviates-nonalcoholic-steatohepatitis-by-inhibiting-nf-%C3%AE%C2%BAb-mediated-hepatocyte-pyroptosis
#1
JOURNAL ARTICLE
Suye Ran, Lingyu Song, Hong Yang, Jiangnan Yu, Yunhuan Zhen, Qi Liu
PURPOSE: Nonalcoholic steatohepatitis (NASH) is the progressive form of nonalcoholic fatty liver disease (NAFLD), which has a high risk of cirrhosis, liver failure, and hepatocellular carcinoma. Piperine (Pip) is an extract of plants with powerful anti-inflammatory effects, however, the function of Pip in NASH remains elusive. Here, we aim to explore the role of Pip in NASH and to find the possible mechanisms. METHODS: Methionine and choline-deficient (MCD) diets were used to induce steatohepatitis, methionine- and choline-sufficient (MCS) diets were used as the control...
2024: PloS One
https://read.qxmd.com/read/38542408/the-molfa1-protein-regulates-fungal-development-and-septin-ring-formation-in-magnaporthe-oryzae
#2
JOURNAL ARTICLE
Jia-Qi Wu, Xue-Ming Zhu, Jian-Dong Bao, Jiao-Yu Wang, Xiao-Ping Yu, Fu-Cheng Lin, Lin Li
Septins play a key regulatory role in cell division, cytokinesis, and cell polar growth of the rice blast fungus ( Magnaporthe oryzae ). We found that the organization of the septin ring, which is essential for appressorium-mediated infection in M. oryzae , requires long-chain fatty acids (LCFAs), which act as mediators of septin organization at membrane interfaces. However, it is unclear how septin ring formation and LCFAs regulate the pathogenicity of the rice blast fungus. In this study, a novel protein was named MoLfa1 because of its role in LCFAs utilization...
March 19, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38535401/-wolbachia-infection-through-hybridization-to-enhance-an-incompatible-insect-technique-based-suppression-of-aedes-albopictus-in-eastern-spain
#3
JOURNAL ARTICLE
Maria Cholvi, María Trelis, Rubén Bueno-Marí, Messaoud Khoubbane, Rosario Gil, Antonio Marcilla, Riccardo Moretti
The emergence of insecticide resistance in arbovirus vectors is putting the focus on the development of new strategies for control. In this regard, the exploitation of Wolbachia endosymbionts is receiving increasing attention due to its demonstrated effectiveness in reducing the vectorial capacity of Aedes mosquitoes. Here, we describe the establishment of a naïve Wolbachia infection in a wild Aedes albopictus population of eastern Spain through a hybridization approach to obtain males capable of sterilizing wild females...
March 20, 2024: Insects
https://read.qxmd.com/read/38534836/anatomically-inspired-robotic-finger-with-sma-tendon-actuation-for-enhanced-biomimetic-functionality
#4
JOURNAL ARTICLE
Renke Liu, Huakai Zheng, Maroš Hliboký, Hiroki Endo, Shuyao Zhang, Yusuke Baba, Hideyuki Sawada
This research introduces an advanced robotic finger designed for future generalist robots, closely mimicking the natural structure of the human finger. The incorporation of rarely discussed anatomical structures, including tendon sheath, ligaments, and palmar plates, combined with the usage of anatomically proven 3D models of the finger, give rise to the highly accurate replication of human-like soft mechanical fingers. Benefiting from the accurate anatomy of muscle insertions with the utilization of Shape Memory Alloy (SMA) wires' muscle-like actuation properties, the bonding in-between the flexor tendons and extensor tendons allows for the realization of the central and lateral band of the finger anatomy...
March 1, 2024: Biomimetics
https://read.qxmd.com/read/38534718/one-hundred-explicit-definitions-of-potentially-inappropriate-prescriptions-of-antibiotics-in-hospitalized-older-patients-the-results-of-an-expert-consensus-study
#5
JOURNAL ARTICLE
Nicolas Baclet, Emmanuel Forestier, Gaëtan Gavazzi, Claire Roubaud-Baudron, Vincent Hiernard, Rozenn Hequette-Ruz, Serge Alfandari, Hugues Aumaître, Elisabeth Botelho-Nevers, Pauline Caraux-Paz, Alexandre Charmillon, Sylvain Diamantis, Thibaut Fraisse, Pierre Gazeau, Maxime Hentzien, Jean-Philippe Lanoix, Marc Paccalin, Alain Putot, Yvon Ruch, Eric Senneville, Jean-Baptiste Beuscart
BACKGROUND: In geriatrics, explicit criteria for potentially inappropriate prescriptions (PIPs) are useful for optimizing drug use. OBJECTIVE: To produce an expert consensus on explicit definitions of antibiotic-PIPs for hospitalized older patients. METHODS: We conducted a Delphi survey involving French experts on antibiotic stewardship in hospital settings. During the survey's rounds, the experts gave their opinion on each explicit definition, and could suggest new definitions...
March 20, 2024: Antibiotics
https://read.qxmd.com/read/38529329/recent-advances-of-myotubularin-related-mtmr-protein-family-in-cardiovascular-diseases
#6
REVIEW
Jia Wang, Wei Guo, Qiang Wang, Yongjian Yang, Xiongshan Sun
Belonging to a lipid phosphatase family containing 16 members, myotubularin-related proteins (MTMRs) are widely expressed in a variety of tissues and organs. MTMRs preferentially hydrolyzes phosphatidylinositol 3-monophosphate and phosphatidylinositol (3,5) bis-phosphate to generate phosphatidylinositol and phosphatidylinositol 5-monophosphate, respectively. These phosphoinositides (PIPs) promote membrane degradation during autophagosome-lysosomal fusion and are also involved in various regulatory signal transduction...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38529266/phybers-a-package-for-brain-tractography-analysis
#7
JOURNAL ARTICLE
Lazara Liset González Rodríguez, Ignacio Osorio, Alejandro Cofre G, Hernan Hernandez Larzabal, Claudio Román, Cyril Poupon, Jean-François Mangin, Cecilia Hernández, Pamela Guevara
We present a Python library (Phybers) for analyzing brain tractography data. Tractography datasets contain streamlines (also called fibers) composed of 3D points representing the main white matter pathways. Several algorithms have been proposed to analyze this data, including clustering, segmentation, and visualization methods. The manipulation of tractography data is not straightforward due to the geometrical complexity of the streamlines, the file format, and the size of the datasets, which may contain millions of fibers...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38528700/piperine-mitigates-oxidative-stress-inflammation-and-apoptosis-in-the-testicular-damage-induced-by-cyclophosphamide-in-mice
#8
JOURNAL ARTICLE
Fatemeh Fani, Seyed Jalal Hosseinimehr, Mehryar Zargari, Mansoureh Mirzaei, Abbasali Karimpour Malekshah, Fereshteh Talebpour Amiri
Although cyclophosphamide (CP) has been approved as an anticancer drug, its toxic effect on most organs, especially the testis, has been established. Piperine (PIP) is an alkaloid that has antioxidant, antiapoptotic, and anti-inflammatory activities. This study was investigated the protective effects of PIP on CP-induced testicular toxicity in the mice. In this experimental study, 48 adult male BALB/c mice (30-35 g) were divided into six groups (n = 8), receiving normal saline (C), 5 mg/kg of PIP (PIP5), 10 mg/kg of PIP (PIP10), 200 mg/kg of CP, 200 mg/kg of CP + PIP5, and 200 mg/kg of CP + PIP10...
April 2024: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/38528450/the-effect-of-early-mobilisation-%C3%A2-14%C3%A2-days-on-pathophysiological-and-functional-outcomes-in-animals-with-induced-spinal-cord-injury-a-systematic-review-with-meta-analysis
#9
JOURNAL ARTICLE
Natalie Gray, Junaid Shaikh, Alison Cowley, Vicky Goosey-Tolfrey, Pip Logan, Nasir Quraishi, Vicky Booth
INTRODUCTION: The optimum time to mobilise (standing, walking) following spinal cord injury (SCI) is unknown but may have implications for patient outcomes. There are no high-quality experimental studies that examine this issue, with a paucity of guidance for clinicians. Pre-clinical studies lead research in this field and can contribute to knowledge and support future clinical practice. OBJECTIVE: to evaluate the effect of early compared to no mobilisation on pathophysiological and functional outcomes in animals with induced SCI...
March 25, 2024: BMC Neuroscience
https://read.qxmd.com/read/38527619/surgical-treatment-of-trigger-finger-a-comparative-study-of-a1-pulley-opening-versus-ulnar-superficialis-slip-resection
#10
JOURNAL ARTICLE
Taha Mouhib, Jerome Jeudy, Yann Saint Cast, Fabrice Rabarin, Nicolas Bigorre
Trigger finger is a common condition. Surgery most frequently involves opening the A0 and A1 pulleys. However, this shows limited effectiveness in correcting proximal interphalangeal joint fixed flexion deformity. The present study aimed to compare clinical outcomes between two surgical techniques for trigger finger treatment. This retrospective study included 127 patients, 72 of whom underwent resection of the ulnar slip of the flexor superficialis, and 55 underwent opening of the pulleys. Study data comprised patient characteristics, range of motion, proximal interphalangeal fixed flexion deformity measurement, Quick-DASH and PRWE scores, and overall satisfaction...
March 23, 2024: Hand Surgery and Rehabilitation
https://read.qxmd.com/read/38527344/industry-sponsorship-bias-in-collagenase-clinical-trials-for-dupuytren-disease-a-meta-analysis
#11
JOURNAL ARTICLE
Kelsey M Gray, Priyenka Khatiwada, Anthony E Capito
BACKGROUND: Collagenase clostridium histolyticum (collagenase) was introduced in 2010 creating a nonoperative treatment option for Dupuytren disease with promising results in sponsored clinical trials. A meta-analysis was performed to investigate industry sponsorship bias. METHODS: A systematic review of collagenase treatment of Dupuytren contracture was conducted. Articles containing mesh terms including "microbial collagenase" and "Dupuytren's contracture" were searched and limited to only clinical trials with similar protocols for inclusion...
April 1, 2024: Annals of Plastic Surgery
https://read.qxmd.com/read/38526528/global-potential-energy-surfaces-by-compressed-state-multistate-pair-density-functional-theory-for-hyperthermal-collisions-in-the-o2-o2-system
#12
JOURNAL ARTICLE
Jie Jiang, Jiawei Yang, Qizhen Hong, Quanhua Sun, Jun Li
Interactions between oxygen molecules play an important role in atmospheric chemistry and hypersonic flow chemistry in atmospheric entries. Recently, high-quality ab initio potential energy surface (PES) of the quintet O4 was reported by Paukku et al. [J. Chem. Phys. 147, 034301 (2017)]. 10543 configurations were sampled and calculated at the level of MS-CASPT2/maug-cc-pVTZ with scaled external correlation. The PES was fitted to a many-body (MB) form with the many-body part described by the permutationally invariant polynomial approach (MB-PIP)...
March 25, 2024: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://read.qxmd.com/read/38525159/nir-ii-emissive-donor-acceptor-donor-fluorophores-for-dual-fluorescence-bioimaging-and-photothermal-therapy-applications
#13
JOURNAL ARTICLE
Nicholas E Sparks, Cameron Smith, Terrence Stahl, Dhanush L Amarasekara, Christine Hamadani, Ethan Lambert, Sheng Wei Tang, Anuja Kulkarni, Blaine M Derbigny, Gaya S Dasanayake, George Taylor, Maryam Ghazala, Nathan I Hammer, Alexander Y Sokolov, Nicholas C Fitzkee, Eden E L Tanner, Davita L Watkins
Fluorescence bioimaging with near-infrared II (NIR-II) emissive organic fluorophores has proven to be a viable noninvasive diagnostic technique. However, there is still the need for the development of fluorophores that possess increased stability as well as functionalities that impart stimuli responsiveness. Through strategic design, we can synthesize fluorophores that possess not only NIR-II optical profiles but also pH-sensitivity and the ability to generate heat upon irradiation. In this work, we employ a donor-acceptor-donor (D-A-D) design to synthesize a series of NIR-II fluorophores...
March 21, 2024: Journal of Materials Chemistry. C, Materials for Optical and Electronic Devices
https://read.qxmd.com/read/38523877/effect-of-dexmedetomidine-on-oxygen-and-intrapulmonary-shunt-qs-qt-during-one-lung-ventilation-in-pediatric-surgery-a-randomized-controlled-trial
#14
JOURNAL ARTICLE
Ayham Khddam, Faten Rostom, Mohammad Y Hajeer
Background One-lung ventilation (OLV) is a common ventilation technique used during thoracic surgery. It can cause serious complications in children, and hypoxic pulmonary vasoconstriction (HPV) is a protective mechanism against the resulting hypoxia. Dexmedetomidine does not affect HPV, so we will investigate its impact on the partial pressure of oxygen in arterial blood (PaO2) and pulmonary shunt fraction (Qs/Qt). Methods Children who underwent OLV were divided into two equal groups. The Dex group received 0...
March 2024: Curēus
https://read.qxmd.com/read/38519117/economic-evaluation-of-a-trial-exploring-the-effects-of-a-web-based-support-tool-for-parents-of-children-with-juvenile-idiopathic-arthritis
#15
JOURNAL ARTICLE
Chris Flood, Shashivadan P Hirani, Kathleen Mulligan, Jo Taylor, Sally Harris, Lucy R Wedderburn, Stanton P Newman
OBJECTIVE: To explore the cost-effectiveness of a web-based support tool for parents of children with Juvenile Idiopathic Arthritis. METHODS: A multi-centred randomised controlled trial was conducted in paediatric rheumatology centres in England. The WebParC intervention consisted of online information about JIA and its treatment and a toolkit using cognitive-behavioural therapy principles to support parents manage their child's JIA. An economic evaluation was performed alongside the trial involving 220 parents...
March 22, 2024: Rheumatology
https://read.qxmd.com/read/38518386/reduction-of-haemoglobin-is-related-to-metal-mixtures-exposure-in-chinese-preschoolers-joint-effect-models
#16
JOURNAL ARTICLE
Ye Fu, Minghui He, Yang Liu, Mingzhu Li, Meiqin Zhu, Yan Wang, Wei Lin, Lili Yu, Liting Yang, Yao Zhang, Yanli Liu, Hongxian Ji, Hongcheng Ding, Jing Wang
Heavy metal exposure is a known risk factor for hematologic disorders in children, yet the impact of co-exposure to multiple metals remains underexplored. This cross-sectional study investigates the relationship between urinary levels of 23 metals and haemoglobin (Hb) in 1460 Chinese preschoolers. The concentrations of the 23 urinary metals were quantified using an inductively coupled plasma mass spectrometer, while Hb levels were assessed through finger prick blood samples. To evaluate the co-exposure effects, we employed three approaches: Generalized linear regression model, joint effect models including Quantile g-Computation and Bayesian Kernel Machine Regression (BKMR)...
March 5, 2024: Journal of Trace Elements in Medicine and Biology
https://read.qxmd.com/read/38511664/dft-investigation-of-coupling-constant-anomalies-in-substituted-%C3%AE-lactams
#17
JOURNAL ARTICLE
Emily B Crull, Alexei V Buevich, Gary E Martin, Rohit Mahar, Bo Qu, Chris H Senanayake, Tadeusz F Molinski, R Thomas Williamson
β-lactams are a chemically diverse group of molecules with a wide range of biological activities. Having recently observed curious trends in 2 JHH coupling values in studies on this structural class, we sought to obtain a more comprehensive understanding of these diagnostic NMR parameters, specifically interrogating 1 JCH , 2 JCH , and 2 JHH , to differentiate 3- and 4-monosubstituted β-lactams. Further investigation using computational chemistry methods was employed to explore the geometric and electronic origins for the observed and calculated differences between the two substitution patterns...
March 21, 2024: Magnetic Resonance in Chemistry: MRC
https://read.qxmd.com/read/38510867/ganglion-cysts-in-the-hallux-a-report-of-two-cases
#18
Hirotaka Fukushima, Tadashi Kimura, Mitsuru Saito, Makoto Kubota
We experienced two cases of intractable hallux ganglion. Case 1 was a 70-year-old woman with a recurrent ganglion and severe pain on the plantar aspect of the hallux. The continuity between the mass and the distal flexor hallucis longus (FHL) tendon sheath was confirmed. The ganglion was resected along with part of the tendon sheath, and the tendon sheath was incised as proximally as possible. Case 2 was a 69-year-old woman with a ganglion on the dorsal aspect of the interphalangeal joint that repeatedly ruptured due to thinning of the skin...
February 2024: Curēus
https://read.qxmd.com/read/38509107/structure-of-an-open-k-atp-channel-reveals-tandem-pip-2-binding-sites-mediating-the-kir6-2-and-sur1-regulatory-interface
#19
JOURNAL ARTICLE
Camden M Driggers, Yi-Ying Kuo, Phillip Zhu, Assmaa ElSheikh, Show-Ling Shyng
ATP-sensitive potassium (KATP ) channels, composed of four pore-lining Kir6.2 subunits and four regulatory sulfonylurea receptor 1 (SUR1) subunits, control insulin secretion in pancreatic β-cells. KATP channel opening is stimulated by PIP2 and inhibited by ATP. Mutations that increase channel opening by PIP2 reduce ATP inhibition and cause neonatal diabetes. Although considerable evidence has implicated a role for PIP2 in KATP channel function, previously solved open-channel structures have lacked bound PIP2 , and mechanisms by which PIP2 regulates KATP channels remain unresolved...
March 20, 2024: Nature Communications
https://read.qxmd.com/read/38509082/extreme-li-mg-selectivity-via-precise-ion-size-differentiation-of-polyamide-membrane
#20
JOURNAL ARTICLE
Quan Peng, Ruoyu Wang, Zilin Zhao, Shihong Lin, Ying Liu, Dianyu Dong, Zheng Wang, Yiman He, Yuzhang Zhu, Jian Jin, Lei Jiang
Achieving high selectivity of Li+ and Mg2+ is of paramount importance for effective lithium extraction from brines, and nanofiltration (NF) membrane plays a critical role in this process. The key to achieving high selectivity lies in the on-demand design of NF membrane pores in accordance with the size difference between Li+ and Mg2+ ions, but this poses a huge challenge for traditional NF membranes and difficult to be realized. In this work, we report the fabrication of polyamide (PA) NF membranes with ultra-high Li+ /Mg2+ selectivity by modifying the interfacial polymerization (IP) process between piperazine (PIP) and trimesoyl chloride (TMC) with an oil-soluble surfactant that forms a monolayer at oil/water interface, referred to as OSARIP...
March 20, 2024: Nature Communications
keyword
keyword
83188
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.