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https://www.readbyqxmd.com/read/28437660/an-experimental-analysis-of-shell-failure-in-breast-implants
#1
N G Ramião, P S Martins, M L Barroso, D C Santos, A A Fernandes
Breast implant durability and the mechanisms of rupture are important topics in the medical community, for patients, manufactures and regulatory medical agencies. After concerns about the Poly Implant Prosthesis (PIP) implants, the need for understanding the adverse outcomes and the failure mode to improve the breast implants increased. The objective of this research is to analyze and describe the rupture characteristics of failed explanted PIP implants to study the modes and causes of rupture. Eleven explanted PIP implants were analyzed by visual inspection and scanning electron microscopy (SEM)...
April 6, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28437194/comparison-of-three-final-irrigation-activation-techniques-effects-on-canal-cleanness-smear-layer-removal-and-dentinal-tubule-penetration-of-two-root-canal-sealers
#2
Elmas Turkel, Emel Olga Onay, Mete Ungor
OBJECTIVE: The aim of this study was to compare three final irrigation activation techniques with respect to their effects on debridement efficacy, smear layer removal, and dentinal tubule penetration of two different root canal sealers. BACKGROUND DATA: Different applications to improve the delivery of irrigating solutions within the root canal system are currently being investigated, as not all of the mechanisms and effects of these techniques have been clearly identified...
February 22, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28432471/differentiating-middle-ear-and-medial-olivocochlear-effects-on-transient-evoked-otoacoustic-emissions
#3
Kendra L Marks, Jonathan H Siegel
The response of the inner ear is modulated by the middle ear muscle (MEM) and olivocochlear (OC) efferent systems. Both systems can be activated reflexively by acoustic stimuli delivered to one or both ears. The acoustic middle ear muscle reflex (MEMR) controls the transmission of acoustic signals through the middle ear, while reflex activation of the medial component of the olivocochlear system (the MOCR) modulates cochlear mechanics. The relative prominence of the two efferent systems varies widely between species...
April 21, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28431157/agreement-between-renal-prescribing-references-and-determination-of-prescribing-appropriateness-in-hospitalised-patients-with-chronic-kidney-disease
#4
Michelle O'Shaughnessy, Niamh Allen, John O'Regan, Edwina Payne-Danson, Lise Mentre, Dawn Davin, Peter Lavin, Tamasine Grimes
Background: Chronic kidney disease (CKD) is a risk factor for adverse drug events. The clinical significance of discordance between renal prescribing references is unknown. Aim: We determined the prevalence of potentially inappropriate prescribing (PIP) in CKD, measured agreement between two prescribing references, and assessed potential for harm consequent to PIP. Design: Single-centre observational study. Methods: A random sample of hospitalised patients with CKD were grouped according to baseline CKD stage (3, 4, or 5)...
April 18, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28431141/grade-and-location-of-power-doppler-are-predictive-of-damage-progression-in-rheumatoid-arthritis-patients-in-clinical-remission-by-anti-tumour-necrosis-factor-%C3%AE
#5
Bernd Raffeiner, Enrico Grisan, Costantino Botsios, Roberto Stramare, Gaia Rizzo, Livio Bernardi, Leonardo Punzi, Francesca Ometto, Andrea Doria
Objectives.: To investigate power Doppler (PD) signal, grade and location and their association with radiographic progression in RA patients in remission. Methods: . A prospective observational study was conducted in 125 consecutive RA patients in stable 28-joint DAS (DAS28) remission (⩾6 months) achieved on anti-TNF-α. At baseline, patients in stable remission underwent radiographic and US examination of the wrists and MCP, PIP and MTP joints. Semi-quantitative PD scoring (0-3) was recorded...
April 20, 2017: Rheumatology
https://www.readbyqxmd.com/read/28427883/born-not-breathing-a-randomised-trial-comparing-two-self-inflating-bag-masks-during-newborn-resuscitation-in-tanzania
#6
Monica Thallinger, Hege Langli Ersdal, Fortunata Francis, Anita Yeconia, Estomih Mduma, Hussein Kidanto, Jørgen Erland Linde, Joar Eilevstjønn, Nina Gunnes, Ketil Størdal
AIMS: Effective ventilation is crucial to save non-breathing newborns. We compared standard equipment for newborn resuscitation to a new Upright bag, in an area with high neonatal mortality. METHODS: Newborns requiring resuscitation at Haydom Lutheran Hospital, Tanzania, were ventilated with 230ml standard or 320ml Upright bag-mask by weekly non-blinded block randomization. A Laerdal Newborn Resuscitation Monitor collected ventilation data through a flow sensor between mask and bag and heart rate with electrocardiography electrodes...
April 17, 2017: Resuscitation
https://www.readbyqxmd.com/read/28420608/the-molecular-mechanisms-of-plant-plasma-membrane-intrinsic-proteins-trafficking-and-stress-response
#7
Wang Xing, Zhang Jilong, Feng Xiuxiu, Li Hongjie, Zhang Genfa
Plasma membrane intrinsic proteins (PIPs) are plant channel proteins located on the plasma membrane. PIPs transfer water, CO2 and small uncharged solutes through the plasma membrane. PIPs have high selectivity to substrates, suggestive of a central role in maintaining cellular water balance. The expression, activity and localization of PIPs are regulated at the transcriptional and post-translational levels, and also affected by environmental factors. Numerous studies indicate that the expression patterns and localizations of PIPs can change in response to abiotic stresses...
April 20, 2017: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/28414008/implementation-utilization-and-influence-of-a-community-based-participatory-nutrition-promotion-programme-in-rural-ethiopia-programme-impact-pathway-analysis
#8
Yunhee Kang, Seungman Cha, Sarah Yeo, Parul Christian
OBJECTIVE: A community-based participatory nutrition promotion (CPNP) programme, involving a 2-week group nutrition session, attempted to improve child feeding and hygiene. The implementation, utilization and influence of the CPNP programme were examined by programme impact pathway (PIP) analysis. DESIGN: Five CPNP programme components were evaluated: (i) degree of implementation; (ii) participants' perception of the nutrition sessions; (iii) participants' message recall; (iv) utilization of feeding and hygiene practices at early programme stage; and (v) participants' engagement in other programmes...
April 17, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28411410/spatio-temporal-patterns-of-event-related-potentials-related-to-audiovisual-synchrony-judgments-in-older-adults
#9
Yu Man Chan, Michael Julian Pianta, Stefan Bode, Allison Maree McKendrick
Older adults have altered perception of the relative timing between auditory and visual stimuli, even when stimuli are scaled to equate detectability. To help understand why, this study investigated the neural correlates of audiovisual synchrony judgments in older adults using electroencephalography (EEG). Fourteen younger (18-32 year old) and 16 older (61-74 year old) adults performed an audiovisual synchrony judgment task on flash-pip stimuli while EEG was recorded. All participants were assessed to have healthy vision and hearing for their age...
March 18, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28403594/the-effect-of-surgical-technique-on-hemodynamics-arterial-oxygenation-and-pulmonary-mechanics-in-radical-prostatectomy-operations
#10
Yucel Yuce, Kutlu Hakan Erkal, Cemal Goktas, Bilal Eryildirim, Kemal Sarica
OBJECTIVE: The effects of surgical technique on respiratory mechanics, arterial oxygenation and hemodynamics in radical prostatectomy operation were investigated. METHODS: The study was planned on ASA II-III, 40-65 years old, fourty patients scheduled for radical prostatectomy under general anesthesia. They were divided into two groups: perineal and suprapubic (Group P, n = 20; Group S, n = 20). Heart rate, mean arterial blood pressure, arterial oxygen saturation (SpO2), partial pressure of end-tidal carbon dioxide (PEtCO2), Peak inspiratory pressure (PIP), plato pressure (Pplato), partial pressure of oxygen in arterial blood (PaO2), partial pressure of carbon dioxide in arterial blood (PaCO2) values were evaluated at 10 minutes after induction...
March 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28401820/-a-man-with-a-curved-deformity-of-the-hand
#11
E M van Soest, G J de Jong, L Korswagen
A 63-year-old male was seen at the rheumatology outpatient clinic because of a curved deformity of his left hand, with fixed flexion of the MCP joints and hyperextension of the PIP and DIP joints. This so-called striatal hand, a feature of Parkinson's disease, can easily be confused with rheumatoid arthritis or Dupuytren's contracture.
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28399930/radiographic-damage-in-hands-and-wrists-of-patients-with-juvenile-idiopathic-arthritis-after-29%C3%A2-years-of-disease-duration
#12
Anne M Selvaag, Eva Kirkhus, Lena Törnqvist, Vibke Lilleby, Hanne A Aulie, Berit Flatø
BACKGROUND: There are few studies on radiographic outcome after long-term disease duration in juvenile idiopathic arthritis (JIA). We wanted to evaluate 29-year radiographic outcome in hands/wrists and predictors of damage in patients with long-term active JIA. METHODS: Patients diagnosed from 1980 to 1985, who had active disease at 15-, 23- or 29-year follow-up and arthritis in the wrists during the disease course, were reexamined with radiographs of hands/wrists...
April 11, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28399118/feasibility-and-physiological-effects-of-non-invasive-neurally-adjusted-ventilatory-assist-niv-nava-in-preterm-infants
#13
Christopher Gibu, Phillip Cheng, Raymond J Ward, Benjamin Castro, Gregory P Heldt
BACKGROUND: Non-invasive Neurally Adjusted Ventilator Assist (NIV-NAVA) was introduced to our clinical practice via a pilot and a randomized observational study to assess its safety, feasibility, and short term physiological effects. METHODS: The pilot protocol applied NIV-NAVA to 11 infants on nasal CPAP, high-flow nasal cannula (HFNC), or nasal IMV (NIMV), in multiple 2-4 h periods of NIV-NAVA for comparison. This provided the necessary data to design a randomized, controlled observational cross-over study in 8 additional infants to compare the physiological effects of NIV-NAVA to NIMV during 2-hour steady state conditions...
April 11, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28398408/-uno-studio-sul-processo-di-riconciliazione-terapeutica-del-paziente-in-un-ospedale-oncologico
#14
Frida Gorreja, Vera Damuzzo, Umberto Gallo, Alberto Russi, Francesco Lo Re, Susanna Ciampalini, Lucia Guidotti, Marta Serena, Angelo Claudio Palozzo
Riassunto. Obiettivi. Lo scopo di questo studio è stato valutare l'impatto della riconciliazione terapeutica nella pratica clinica dal punto di vista del farmacista ospedaliero. Metodi. È stata condotta un'indagine riguardante i trattamenti farmacologici assunti dai pazienti al momento dell'ammissione e della dimissione in un ospedale oncologico. Il farmacista ha inserito i dati raccolti in un supporto informatico che, impiegando i criteri di STOPP (Screening Tool of Older Persons' Potentially Inappropriate Prescriptions) e il database Micromedex™, utile per valutare le interazioni farmacologiche, ha prodotto automaticamente un report che indicava le possibili incongruenze farmacologiche...
March 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28397086/structure-activity-relationship-of-piperine-and-its-synthetic-amide-analogs-for-therapeutic-potential-to-prevent-experimentally-induced-er-stress-in-vitro
#15
Ayat S Hammad, Sreenithya Ravindran, Ashraf Khalil, Shankar Munusamy
Endoplasmic reticulum (ER) is the key organelle involved in protein folding and maturation. Emerging studies implicate the role of ER stress in the development of chronic kidney disease. Thus, there is an urgent need for compounds that could ameliorate ER stress and prevent CKD. Piperine and its analogs have been reported to exhibit multiple pharmacological activities; however, their efficacy against ER stress in kidney cells has not been studied yet. Hence, the goal of this study was to synthesize amide-substituted piperine analogs and screen them for pharmacological activity to relieve ER stress using an in vitro model of tunicamycin-induced ER stress using normal rat kidney (NRK-52E) cells...
April 10, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28396315/peaches-and-cream-in-a-multi-ethnic-society
#16
Pip Fisher
No abstract text is available yet for this article.
April 10, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28396208/efficacy-of-a-high-potency-o1-manisa-foot-and-mouth-disease-vaccine-in-cattle-against-heterologous-challenge-with-a-field-virus-from-the-o-me-sa-ind-2001-lineage-collected-in-north-africa
#17
Emma Fishbourne, Anna B Ludi, Ginette Wilsden, Pip Hamblin, Bob Statham, Abdelghani Bin-Tarif, Emiliana Brocchi, Santina Grazioli, Aldo Dekker, Phaedra Eblé, Donald P King
Outbreaks of foot-and-mouth disease (FMD) in North Africa (2013) and the Gulf States (2013) of the Middle East have been caused by a FMD viral lineage (O/ME-SA/Ind-2001) that was before 2013 restricted to the Indian Sub-continent. This study was undertaken to assess the in vivo efficacy of a FMD virus emergency vaccine type O1 Manisa against heterologous challenge with a representative field virus (O/ALG/3/2014) from this emerging lineage. This widely available vaccine was selected since in vitro vaccine-matching results gave inconclusive results as to whether or not it would be protective...
May 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28390777/on-the-role-of-ephrina2-in-auditory-function
#18
Neil J Ingham, Karen P Steel, Uwe Drescher
Recent findings suggest that the manipulation of the EphA/ephrinA system can improve hearing threshold sensitivity in the auditory system (Yates et al., 2014). These results appear to open-up the possibility that pharmacological manipulation of this system could lead to the development of treatments to cure some types of hearing loss. As a first step towards this goal, we have performed a further series of auditory brainstem evoked potential recordings on ephrinA2 homozygous knockout mice and their wildtype littermates in order to replicate the previously reported findings...
April 5, 2017: Hearing Research
https://www.readbyqxmd.com/read/28390076/sugar-and-hexokinase-suppress-expression-of-pip-aquaporins-and-reduce-leaf-hydraulics-that-preserves-leaf-water-potential
#19
Gilor Kelly, Nir Sade, Adi Doron-Faigenboim, Stephen Lerner, Arava Shatil-Cohen, Yelena Yeselson, Aiman Egbaria, Jayaram Kottapalli, Arthur A Schaffer, Menachem Moshelion, David Granot
Sugars affect central aspects of plant physiology, including photosynthesis, stomatal behavior and the loss of water through the stomata. Yet, the potential effects of sugars on plant aquaporins (AQPs) and water conductance have not been examined. We used database and transcriptional analyses, as well as cellular and whole-plant functional techniques to examine the link between sugar-related genes and AQPs. Database analyses revealed a high level of correlation between the expression of AQPs and that of sugar-related genes, including the Arabidopsis hexokinases 1 (AtHXK1)...
April 8, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28389081/the-use-of-residual-collagenase-for-single-digits-with-multiple-joint-dupuytren-contractures
#20
Louis C Grandizio, Anil Akoon, Janice Heimbach, Jove Graham, Joel C Klena
PURPOSE: Standard 0.58 mg (0.25 mL) collagenase Clostridium histolyticum (CCH) preparations result in unused CCH that is often discarded. Our purpose was to assess the results on Dupuytren contractures affecting both the metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints in the same digit utilizing an injection containing the maximum CCH volume that can be withdrawn from a single vial. METHODS: A consecutive series of patients with MCP and PIP cords in the same digit received a single treatment with 2 injections totaling 0...
April 4, 2017: Journal of Hand Surgery
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