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https://www.readbyqxmd.com/read/28720057/use-of-integra-in-the-management-of-complex-hand-wounds-from-cancer-resection-and-nonburn-trauma
#1
Michael Reynolds, David A Kelly, Nicholas J Walker, Clayton Crantford, Anthony J Defranzo
BACKGROUND: Despite extensive use of Integra in burn reconstruction, little has been published regarding its utility in complex hand wounds from nonburn trauma or cancer resection. This study aimed to review outcomes following Integra use for hand reconstruction following cancer resection or nonburn trauma with exposed bone, joints, and/or tendons. METHODS: Retrospective review was performed of patients undergoing hand reconstruction with Integra for exposed bones, joints, or tendons over a 6-year period at a single institution...
February 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28720009/the-effect-of-isolated-finger-stiffness-on-adjacent-digit-function
#2
Rasha Baaqeel, Kitty Wu, Shrikant J Chinchalkar, Douglas C Ross
BACKGROUND: Isolated stiffness in a single finger can affect the function of adjacent digits and decrease overall hand function due to the quadriga phenomenon. This study objectively quantifies the dysfunctional impact of each individual stiff finger upon the remaining digits. METHODS: Twenty-five individuals (10 men and 15 women) with a mean age of 31 years (range, 18-58 years) without any upper limb pathology, neuropathy, or systemic illness were recruited. Volar-based finger splints were used to hold individual digits of the dominant hand (24 right and 1 left) sequentially in full extension at the metacarpophalangeal (MCP), proximal interphalangeal (PIP), and distal interphalangeal (DIP) joints...
March 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28713408/transcriptome-analyses-shed-new-insights-into-primary-metabolism-and-regulation-of-blumeria-graminis-f-sp-tritici-during-conidiation
#3
Fan-Song Zeng, Fabrizio Menardo, Min-Feng Xue, Xue-Jiang Zhang, Shuang-Jun Gong, Li-Jun Yang, Wen-Qi Shi, Da-Zhao Yu
Conidia of the obligate biotrophic fungal pathogen Blumeria graminis f. sp. tritici (Bgt) play a vital role in its survival and rapid dispersal. However, little is known about the genetic basis for its asexual reproduction. To uncover the primary metabolic and regulatory events during conidiation, we sequenced the transcriptome of Bgt epiphytic structures at 3 (vegetative hyphae growth), 4 (foot cells initiation), and 5 (conidiophore erection) days post-inoculation (dpi). RNA-seq analyses identified 556 and 404 (combined 685) differentially expressed genes (DEGs) at 4 and 5 dpi compared with their expression levels at 3 dpi, respectively...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28712012/development-of-an-mr-compatible-hand-exoskeleton-that-is-capable-of-providing-interactive-robotic-rehabilitation-during-fmri-imaging
#4
Sangjoon J Kim, Yeongjin Kim, Hyosang Lee, Pouya Ghasemlou, Jung Kim
Following advances in robotic rehabilitation, there have been many efforts to investigate the recovery process and effectiveness of robotic rehabilitation procedures through monitoring the activation status of the brain. This work presents the development of a two degree-of-freedom (DoF) magnetic resonance (MR)-compatible hand device that can perform robotic rehabilitation procedures inside an fMRI scanner. The device is capable of providing real-time monitoring of the joint angle, angular velocity, and joint force produced by the metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints of four fingers...
July 15, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28708514/feeding-rosemary-leaves-powder-ameliorates-rooster-age-related-subfertility
#5
Seyyed Mohsen Borghei-Rad, Saeed Zeinoaldini, Mahdi Zhandi, Hossein Moravej, Mahdi Ansari
Having a high proportion of polyunsaturated fatty acids avian spermatozoa predispose to lipoperoxidation which results in fertility reduction. In the current study, rosemary leaves powder (RLP) was fed to senescent breeder roosters to improve their reproductive performance. Twenty four 70-week-old roosters were randomly divided into four groups and received following treatments including 0 (RLP-0), 2.5 (RLP-2.5), 5 (RLP-5) or 7.5 (RLP-7.5) g of RLP/kg of diet for eight consecutive weeks. Semen characteristics were evaluated weekly...
June 16, 2017: Theriogenology
https://www.readbyqxmd.com/read/28708251/efficacy-of-photon-initiated-photoacoustic-streaming-on-apically-extruded-debris-with-different-preparation-systems-in-curved-canals
#6
D Arslan, A Kustarci
AIM: To determine the effect of photon-initiated photoacoustic streaming (PIPS) on the extrusion of debris using multiple-file (ProTaper Next-PTN) and single-file (One Shape-OS) continuous rotary systems in curved canals in human molar teeth. METHODOLOGY: Sixty extracted maxillary first molar teeth with curved mesial roots, mature apices and of similar lengths were selected. Teeth with apical diameters larger than size 15 were discarded. The teeth were randomly divided into 4 experimental groups (n=15 teeth per group) according to the file used and irrigation systems: (1) OS with PIPS with a 2940 nm Er:YAG laser (0...
July 14, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28707598/protein-tagging-destruction-and-infection
#7
Chetana Bhaskarla, Manoj Bhosale, Pip Banerjee, Nagasuma Chandra, Dipankar Nandi
Cells possess protein quality control mechanisms to maintain proper cellular homeostasis. In eukaryotes, the roles of the ubiquitination and proteasome-mediated degradation of cellular proteins is well established. Recent studies have elucidated protein tagging mechanisms in prokaryotes, involving transfer messenger RNA (tmRNA) and pupylation. In this review, newer insights and bioinformatics analysis of two distinct bacterial protein tagging machineries are discussed. The machinery for tmRNA-mediated tagging is present in several eubacterial representatives, e...
July 13, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28694230/pharmacokinetics-of-piperacillin-tazobactam-in-plasma-peritoneal-fluid-and-peritoneum-of-surgery-patients-and-dosing-considerations-based-on-site-specific-pharmacodynamic-target-attainment
#8
Naoki Murao, Hiroki Ohge, Kazuro Ikawa, Yusuke Watadani, Shinnosuke Uegami, Norifumi Shigemoto, Norimitsu Shimada, Raita Yano, Toshiki Kajihara, Kenichiro Uemura, Yoshiaki Murakami, Norifumi Morikawa, Taijiro Sueda
Piperacillin-tazobactam (PIP-TAZ) is commonly used to treat intraabdominal infections; however, its penetration into abdominal sites is unclear. A pharmacokinetic analysis of plasma, peritoneal fluid, and peritoneum drug concentrations was conducted to simulate dosing regimens needed to attain the pharmacodynamic target in abdominal sites. PIP-TAZ (4 g-0.5 g) was intravenously administered to 10 patients before abdominal surgery for inflammatory bowel disease. Blood, peritoneal fluid, and peritoneum samples were obtained at the end of infusion (0...
July 7, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28687492/molecular-characterization-of-the-hydroxylase-hmtn-at-1-3%C3%A2-%C3%A3-resolution
#9
Huaidong Zhang, Jie Chen, Houjin Zhang
Himastatin is a novel antibiotic with antitumor and antibacterial activity. In the himastatin biosynthesis pathway, HmtN is responsible for the hydroxylation of the piperazic acid (Pip) motif. Herein, we present the crystal structures of HmtN (1.3 Å), which is the first structure for a cytochrome P450 involved in the hydroxylation of cyclohexadepsipeptide during himastatin biosynthesis. Structure analysis indicated that almost all the surface of HmtN has negative electrostatic potential, only small patches of positive electrostatic potential can be found...
July 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28681572/exploring-perceptions-of-a-rheumatoid-arthritis-specific-smoking-cessation-programme
#10
Pip Aimer, Lisa K Stamp, Simon Stebbings, Vicky Cameron, Sandra Kirby, Gareth J Treharne
AIM: Smoking cessation is an important consideration in the management of rheumatoid arthritis (RA). The aim of the present study was to determine which aspects of a novel three-month smoking cessation intervention were most useful for people with RA, and to identify areas for improvement. METHOD: Thirty-eight current smokers with RA (19 intervention and 19 control) enrolled in a previous randomized controlled trial (RCT) of smoking cessation and two arthritis educators who had provided the intervention were interviewed...
July 6, 2017: Musculoskeletal Care
https://www.readbyqxmd.com/read/28676916/-correction-of-flexible-lesser-toe-deformity-transfer-of-the-flexor-digitorum-longus-tendon
#11
D Arbab, D Frank, B Bouillon, C Lüring
OBJECTIVE: Realignment and pain relief of toes 2-5 by flexor-to-extensor tendon transfer of the flexor digitorum longus (FDL) muscle. INDICATIONS: As an isolated procedure in flexible proximal interphalangeal (PIP) joint flexion and/or flexible metatarsophalangeal (MTP) joint extension (hammer toe). In combination with a metatarsal osteotomy or PIP joint arthrodesis in case of flexible MTP joint extension. CONTRAINDICATIONS: General medical contraindications to surgical interventions...
July 4, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28675548/neopuff-t-piece-resuscitator-mask-ventilation-does-mask-leak-vary-with-different-peak-inspiratory-pressures-in-a-manikin-model
#12
Rajesh Maheshwari, Mark Tracy, Murray Hinder, Audrey Wright
AIM: The aim of this study was to compare mask leak with three different peak inspiratory pressure (PIP) settings during T-piece resuscitator (TPR; Neopuff) mask ventilation on a neonatal manikin model. METHODS: Participants were neonatal unit staff members. They were instructed to provide mask ventilation with a TPR with three PIP settings (20, 30, 40 cm H2 O) chosen in a random order. Each episode was for 2 min with 2-min rest period. Flow rate and positive end-expiratory pressure (PEEP) were kept constant...
July 4, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28673625/current-european-practice-in-the-treatment-of-proximal-interphalangeal-joint-arthritis
#13
REVIEW
Daniel B Herren
There are increasing numbers of proximal interphalangeal (PIP) arthroplasties performed in Europe. Meanwhile, most surgeons prefer arthroplasty over arthrodesis. Silastic arthroplasties remain the most widely used implants. The main disadvantage of the Silastic implants is the limited stability they provide. Correction of pre-existing deformation is difficult. Soft tissue handling and postoperative scarring have an influence on the results of PIP arthroplasty. Different surgical approaches are possible. The most popular approach in Europe is dorsal...
August 2017: Hand Clinics
https://www.readbyqxmd.com/read/28672755/pregnancy-outcomes-among-patients-with-recurrent-pregnancy-loss-and-chromosomal-aberration-ca-without-pgd
#14
Maor Kabessa, Avi Harlev, Michael Friger, Ruslan Sergienko, Baila Litwak, Arie Koifman, Naama Steiner, Asher Bashiri
BACKGROUND: Recurrent pregnancy loss (RPL) is defined by two or more failed clinical pregnancies. Three to four percent of the couples with RPL have chromosomal aberrations (CA) in at least one partner. The parent's structural chromosomal abnormalities may cause an unbalanced karyotype in the conceptus which could lead to implantation failure, early or late pregnancy loss, or delivery of a child with severe physical and/or mental disabilities. OBJECTIVE: To compare live birth rates of couples with CA to couples with normal karyotypes and to investigate medical and obstetric characteristics and pregnancy outcomes of couples with CA and RPL who attend an RPL clinic at a tertiary hospital...
June 26, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28670309/prevalence-of-antibiotic-resistant-escherichia-coli-in-drinking-water-sources-in-hangzhou-city
#15
Zhaojun Chen, Daojun Yu, Songzhe He, Hui Ye, Lei Zhang, Yanping Wen, Wenhui Zhang, Liping Shu, Shuchang Chen
This study investigated the distribution of antibiotic resistant Escherichia coli (E. coli) and examined the possible relationship between water quality parameters and antibiotic resistance from two different drinking water sources (the Qiantang River and the Dongtiao Stream) in Hangzhou city of China. E. coli isolates were tested for their susceptibility to 18 antibiotics. Most of the isolates were resistant to tetracycline (TE), followed by ampicillin (AM), piperacillin (PIP), trimethoprim/sulfamethoxazole (SXT), and chloramphenicol (C)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28666817/what-supports-hospital-pharmacist-prescribing-in-scotland-a-mixed-methods-exploratory-sequential-study
#16
J Fisher, M Kinnear, F Reid, C Souter, D Stewart
While approximately half of all qualified hospital pharmacist independent prescribers (PIPs) in Scotland are active prescribers, there are major differences in prescribing activity across geographical areas. This study aimed to explore, through focus groups, interviews and a questionnaire, hospital PIPs' perceptions of factors associated with prescribing activity and to investigate the infrastructure required to better support active prescribing by PIPs. Findings reinforced the perceived positive impact of supportive pharmacy leadership within the organisation, recognition that prescribing is integral to the clinical pharmacist role and a work environment conducive to prescribing...
June 17, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28666314/gpu-powered-model-analysis-with-pysb-cupsoda
#17
Leonard A Harris, Marco S Nobile, James C Pino, Alexander L R Lubbock, Daniela Besozzi, Giancarlo Mauri, Paolo Cazzaniga, Carlos F Lopez
Summary: A major barrier to the practical utilization of large, complex models of biochemical systems is the lack of open-source computational tools to evaluate model behaviors over high-dimensional parameter spaces. This is due to the high computational expense of performing thousands to millions of model simulations required for statistical analysis. To address this need, we have implemented a user-friendly interface between cupSODA, a GPU-powered kinetic simulator, and PySB, a Python-based modeling and simulation framework...
June 28, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28655184/characterization-of-a-coupled-dna-replication-and-translesion-synthesis-polymerase-supraholoenzyme-from-archaea
#18
Matthew T Cranford, Aurea M Chu, Joshua K Baguley, Robert J Bauer, Michael A Trakselis
The ability of the replisome to seamlessly coordinate both high fidelity and translesion DNA synthesis requires a means to regulate recruitment and binding of enzymes from solution. Co-occupancy of multiple DNA polymerases within the replisome has been observed primarily in bacteria and is regulated by posttranslational modifications in eukaryotes, and both cases are coordinated by the processivity clamp. Because of the heterotrimeric nature of the PCNA clamp in some archaea, there is potential to occupy and regulate specific polymerases at defined subunits...
June 26, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28653714/quasi-classical-trajectory-studies-on-the-full-dimensional-accurate-potential-energy-surface-for-the-oh-h2o-h2o-oh-reaction
#19
Mengna Bai, Dandan Lu, Jun Li
For the symmetric reaction OH + H2O → H2O + OH, ∼48 000 data points are sampled and calculated at the level of the explicitly correlated unrestricted coupled cluster method with single, double, and perturbative triple excitations with the augmented correlation-consistent polarized triple zeta basis set (CCSD(T)-F12a/AVTZ). The data set is then employed to fit the full dimensional accurate potential energy surface (PES) by using the permutation invariant polynomial-neural network (PIP-NN) method, resulting in a total root mean square error (RMSE) of 0...
July 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28645150/gfapy-a-flexible-and-extensible-software-library-for-handling-sequence-graphs-in-python
#20
Giorgio Gonnella, Stefan Kurtz
Summary: GFA 1 and GFA 2 are recently defined formats for representing sequence graphs, such as assembly, variation or splicing graphs. The formats are adopted by several software tools. Availability and Implementation: GfaPy is available open source at https://github.com/ggonnella/gfapy and installable via pip. Contact: gonnella@zbh.uni-hamburg.de. Supplementary information: Supplementary data are available at Bioinformatics online...
June 22, 2017: Bioinformatics
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