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https://www.readbyqxmd.com/read/28343853/factors-influencing-functional-outcome-of-proximal-interphalangeal-joint-collateral-ligament-injury-when-treated-with-buddy-strapping-and-exercise
#1
Young Hak Roh, Young Do Koh, Jae Yun Go, Jung Ho Noh, Hyun Sik Gong, Goo Hyun Baek
STUDY DESIGN: Prospective cohort. INTRODUCTION AND PURPOSE: This study evaluates the factors influencing treatment outcomes of proximal interphalangeal (PIP) joint collateral ligament injuries when treated with buddy strapping. METHODS: Sixty-seven patients treated with buddy strapping for a PIP joint injury were enrolled. The finger range of motion (ROM), grip strength, and a Quick Disability of the Arm, Shoulder, and Hand (QuickDASH) score were assessed at 3 and 6 months after the initial injury...
March 23, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28341088/the-latest-treatment-strategy-for-the-rheumatoid-hand-deformity
#2
Hajime Ishikawa
With a remarkable improvement in the pharmacotherapy of rheumatoid arthritis (RA), severely handicapped patients are very rare to see. Healing, repair and drug-free, and toward radical cure are coming to be possible. In the clinical practice, more than 50% of the patients are in remission. However, some patients are still difficult to reach remission due to comorbidities and economic burden. In the patient with clinical remission, smoldering synovitis so called "silent destructor" is often detected by ultrasonograpy or by synovial histology in the small joints of the hand...
March 22, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28340066/diagnostic-test-accuracy-of-ultrasound-for-synovitis-in-rheumatoid-arthritis-systematic-review-and-meta-analysis
#3
Kaoru Takase-Minegishi, Nobuyuki Horita, Kouji Kobayashi, Ryusuke Yoshimi, Yohei Kirino, Shigeru Ohno, Takeshi Kaneko, Hideaki Nakajima, Richard J Wakefield, Paul Emery
Objective.: To evaluate diagnostic test accuracy of US compared with MRI for the detection of synovitis in RA patients. Methods.: A systematic literature search was performed in the PubMed, EMBASE, Cochrane Library and Web of Science Core Collection databases. Studies evaluating the diagnostic test accuracy of US for synovitis detected by MRI as the reference standard for wrist, MCP, PIP and knee joints were included. To assess the overall accuracy, we calculated the diagnostic odds ratio using a DerSimonian-Laird random effects model and the area under the curve (AUC) for the hierarchical summary receiver operating characteristics using Holling's proportional hazards models...
March 3, 2017: Rheumatology
https://www.readbyqxmd.com/read/28338524/chronic-boutonniere-deformities-supple-or-stiff-a-new-surgical-technique-with-early-mobilization-in-11-cases
#4
Elodie Dubois, Frederic Teboul, Thomas Bihel, Jean-N Goubier
Injuries to the central slip of the extensor mechanism can lead to a Boutonniere deformity with important functional consequences. We report a series of 11 patients treated by lengthening-dorsalizing the lateral bands and tightening the central slip with early mobilization. The average age of the patients was 42 years (14;52). The extension defect of the proximal interphalangeal (PIP) joint was 64 degrees (80;55) and the hyperextension of the distal interphalangeal joint was 10 degrees (15;5). The surgery was performed with peripheral nerve block (sensitive), allowing dynamic adjustment of the tendinous sutures...
March 23, 2017: Techniques in Hand & Upper Extremity Surgery
https://www.readbyqxmd.com/read/28330936/biochemical-principles-and-functional-aspects-of-pipecolic-acid-biosynthesis-in-immunity
#5
Michael Hartmann, Denis Kim, Friederike Bernsdorff, Ziba Ajami-Rashidi, Nicola Scholten, Stefan Schreiber, Tatyana Zeier, Stefan Schuck, Vanessa Reichel-Deland, Jürgen Zeier
The non-protein amino acid pipecolic acid (Pip) regulates plant systemic acquired resistance (SAR) and basal immunity to bacterial pathogen infection. In Arabidopsis thaliana, the Lys aminotransferase AGD2-LIKE DEFENSE RESPONSE PROTEIN1 (ALD1) mediates the pathogen-induced accumulation of Pip in inoculated and distal leaf tissue. Here we show that ALD1 transfers the alpha-amino group of L-Lys to acceptor oxoacids. Combined mass spectrometric and infrared spectroscopic analyses of in vitro assays and plant extracts indicate that the final product of the ALD1-catalysed reaction is enaminic 2,3-dehydropipecolic acid (2,3-DP), whose formation involves consecutive transamination, cyclization and isomerization steps...
March 22, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28329506/n%C3%A3-dulos-subcut%C3%A3-neos-faciales-de-3-meses-de-evoluci%C3%A3-n
#6
Antonio Martinez-Lopez, Israel Pérez-Lopez, Daniel Sánchez-Cano, Ricardo Ruiz-Villaverde
Siliconomas are subcutaneous nodules that usuallyappear as a consequence of the migration of freesilicon implanted in other locations. They are morefrequent in women with abnormal breast implants,such as poly implant prostheses (PIP), but they may alsoappear after illegal injection of free silicone. We reporta 57-year-old woman who attended our Dermatologyclinic complaining of relapsing facial panniculitis ofunknown origin. After a thorough work-up, thesenodules were determined to be the consequence ofdermal filler made with fluid silicone, which had beeninjected 20 years prior...
February 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28327711/a-global-coupled-cluster-potential-energy-surface-for-hcl-oh-%C3%A2-cl-h2o
#7
Junxiang Zuo, Bin Zhao, Hua Guo, Daiqian Xie
A new and more accurate full-dimensional global potential energy surface (PES) for the ground electronic state of the ClH2O system is developed by fitting 15 777 points obtained using an explicitly correlated unrestricted coupled-cluster method with single, double, and perturbative triple excitations (UCCSD(T)-F12b). The fitting is carried out using the permutation invariant polynomial-neural network (PIP-NN) method and has an error of 6.9 meV. The new PES has a slightly lower barrier for the atmospherically important HCl + OH → Cl + H2O reaction than the previous PES based on multi-reference configuration interaction (MRCI) calculations...
March 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28325427/surgical-management-of-closed-isolated-proximal-phalanx-fractures-in-the-long-fingers-functional-outcomes-and-complications-of-87-fractures
#8
A-S Desaldeleer-Le Sant, A Le Sant, V Beauthier-Landauer, N Kerfant, D Le Nen
Finger fractures are the most common skeletal injuries of the upper limbs. The purpose of this study was to evaluate the functional outcomes and complications after surgical management of isolated, closed fractures of the proximal phalanx (PP) of the hand (thumb excluded). Surgical management was indicated in 87 PP fractures. Fractures were reduced and fixed with pins, screws or a plate. Functional outcomes were assessed through the range of motion (ROM) in flexion-extension, hand and finger strength, and the QuickDASH and PRWHE scores...
April 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28318893/design-and-characterization-of-opioid-ligands-based-on-cycle-in-macrocycle-scaffold
#9
Anna Adamska-Bartłomiejczyk, Rossella De Marco, Luca Gentilucci, Alicja Kluczyk, Anna Janecka
The study reports on a series of novel cyclopeptides based on the structure Tyr-[d-Lys-Phe-Phe-Asp]NH2, a mixed mu and kappa opioid receptor agonist with low nanomolar affinity, in which Phe(4) residue was substituted by cyclic amino acids, such as Pro or its six-membered surrogates, piperidine-2-, 3- or 4-carboxylic acids (Pip, Nip and Inp, respectively). All derivatives exhibited high mu- and moderate delta-opioid receptor affinity, and almost no binding to the kappa-opioid receptor. Conformational analysis suggested that the cis conformation of the peptide bond Phe(3)-Xaa(4) influences receptor selectivity through the control of the position of Phe(3) side chain...
February 28, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28315116/evaluating-the-prevalence-of-potentially-inappropriate-prescribing-in-older-adults-in-intermediate-care-facilities-a-cross-sectional-observational-study
#10
Anna Millar, Carmel Hughes, Cristín Ryan
Background Potentially inappropriate prescribing (PIP) [encompassing potentially inappropriate medicines (PIMs) and potential prescribing omissions (PPOs)], is prevalent amongst older adults in primary and secondary care. However, PIP prevalence in intermediate care (IC) is unknown. Objective To determine the prevalence of PIMs/PPOs and associated patient factors. Setting Three IC facilities in Northern Ireland. Method The Screening Tool of Older People's Prescriptions and the Screening Tool to Alert doctors to Right Treatment were used to identify PIP over 8 weeks...
March 17, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28298784/ventilation-of-nonparalyzed-patients-under-anesthesia-with-laryngeal-mask-airway-comparison-of-three-modes-of-ventilation-volume-controlled-ventilation-pressure-controlled-ventilation-and-pressure-controlled-ventilation-volume-guarantee
#11
Maroun Badwi Ghabach, Elie M El Hajj, Rouba D El Dib, Jeanette M Rkaiby, May S Matta, May R Helou
BACKGROUND: Pressure controlled ventilation (PCV) is the preferable mode of ventilation of nonparalyzed patients undergoing anesthesia with laryngeal mask airway (LMA) as compared to volume controlled ventilation (VCV) and spontaneously breathing patient. In this study, we compared the PC-volume guarantee (PC-VG) mode of ventilation with VCV and PCV modes. MATERIALS AND METHODS: A total of 30 patients, American Society of Anesthesiologists (ASA) physical status Classes I and II, scheduled for elective surgery under general anesthesia with a classic LMA were ventilated, subsequently, with the three modes of ventilation: VCV, PCV, and PC-VG for 10 min each mode...
January 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28298365/collagenase-injections-for-dupuytren-s-disease-prospective-cohort-study-assessing-2-year-treatment-effect-durability
#12
Anna Lauritzson, Isam Atroshi
OBJECTIVES: To assess 2-year durability of joint contracture correction following collagenase injections for Dupuytren's disease. DESIGN: Prospective cohort study. SETTING: Orthopaedic Department in Sweden. PARTICIPANTS: Patients with palpable Dupuytren's cord and active extension deficit (AED) ≥30° in the metacarpophalangeal (MCP) and/or proximal interphalangeal (PIP) joint. A surgeon injected 0.80 mg collagenase into multiple cord parts and performed finger manipulation under local anaesthesia after 24-48 hours...
March 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28285299/the-pips-probiotics-in-preterm-infants-study-trial-controlling-the-confounding-factor-of-cross-contamination-unveils-significant-benefits
#13
G Karthikeyan, B Vishnu Bhat
No abstract text is available yet for this article.
February 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28284189/changes-in-intraocular-pressure-and-optic-nerve-sheath-diameter-in-patients-undergoing-robotic-assisted-laparoscopic-prostatectomy-in-steep-45%C3%A2-trendelenburg-position
#14
Sebastian Blecha, Marion Harth, Felix Schlachetzki, Florian Zeman, Christiane Blecha, Pierre Flora, Maximilian Burger, Stefan Denzinger, Bernhard M Graf, Horst Helbig, Michael T Pawlik
BACKGROUND: To evaluate changes in intraocular pressure (IOP) and intracerebral pressure (ICP) reflected by the optic nerve sheath diameter (ONSD) in patients undergoing robotic-assisted laparoscopic prostatectomy (RALP) in permanent 45° steep Trendelenburg position (STP). METHODS: Fifty-one patients undergoing RALP under a standardised anaesthesia. IOP was perioperatively measured in awake patients (T0) and IOP and ONSD 20 min after induction of anaesthesia (T1), after insufflation of the abdomen in supine position (T2), after 30 min in STP (T3), when controlling Santorini's plexus in STP (T4) and before awakening while supine (T5)...
March 11, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28277466/early-results-of-surgical-management-of-camptodactyly
#15
Brady T Evans, Peter M Waters, Donald S Bae
BACKGROUND: We hypothesize that surgery for moderate-to-severe camptodactyly (>50 degrees) results in modest gains in range of motion and improved digital position. METHODS: A retrospective analysis of patients undergoing surgery for camptodactyly at a tertiary children's hospital between 2000 and 2014 was performed. Surgery was indicated for patients with persistent, functionally limiting flexion contractures despite observation, therapy, and splinting. Data were collected on demographics, clinical history and presentation, nonoperative management, surgery, and clinical follow-up, focusing on range of motion at the involved joint...
March 8, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28275279/influence-of-laser-activated-irrigation-with-two-erbium-lasers-on-bond-strength-of-inidividually-formed-fiber-reinforced-composite-posts-to-root-canal-dentin
#16
Ivana Parčina, Amižić, Ivana Miletić, Andrei C Ionescu, Eugenio Brambilla, Dragana Gabrić, Anja Baraba
OBJECTIVE: The aim of this in vitro study was to investigate the effect of laser activated irrigation (LAI) using two erbium lasers on bond strength of individually formed fiber-reinforced composite (FRC) posts to root canal dentin. MATERIALS AND METHODS: Twenty-seven single-rooted human teeth were endodontically treated and after post space preparation divided into three groups (n=9 per group), according to the pre-treatment of post space preparation: 1) Conventional syringe irrigation (CSI) and saline; 2) Er...
December 2016: Acta Stomatologica Croatica
https://www.readbyqxmd.com/read/28274214/the-impact-of-integrated-prevention-and-treatment-on-child-malnutrition-and-health-the-promis-project-a-randomized-control-trial-in-burkina-faso-and-mali
#17
Lieven Huybregts, Elodie Becquey, Amanda Zongrone, Agnes Le Port, Regina Khassanova, Lazare Coulibaly, Jef L Leroy, Rahul Rawat, Marie T Ruel
BACKGROUND: Evidence suggests that both preventive and curative nutrition interventions are needed to tackle child acute malnutrition (AM) in developing countries. In addition to reducing the incidence of AM, providing preventive interventions may also help increase attendance (and coverage) of AM screening, a major constraint in the community-based management of child acute malnutrition (CMAM) model. There is a paucity of evidence-based strategies to deliver integrated preventive and curative interventions effectively and affordably at scale...
March 9, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28272226/different-characteristics-of-ventilator-application-between-tracheostomy-and-noninvasive-positive-pressure-ventilation-patients-with-amyotrophic-lateral-sclerosis
#18
Donghwi Park, Goo Joo Lee, Ha Young Kim, Ju Seok Ryu
The aim of the study was to investigate the appropriate home ventilator settings for patients with amyotrophic lateral sclerosis (ALS).In total, 71 patients with ALS, who had received either a noninvasive positive pressure ventilation (NIPPV) or tracheostomy positive pressure ventilation (TPPV), were included. Accordingly, patients were divided into 2 groups (the TPPV and NIPPV groups). We retrospectively evaluated the values used in home ventilators for patients with ALS, who had maintained a stable level of CO2 on both the arterial blood gas analysis (ABGA) and transcutaneous blood gas monitoring...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28269541/estimation-of-joint-center-and-measurement-of-finger-motion-by-inertial-sensors
#19
Keisuke Kitano, Akihito Ito, Nobutaka Tsujiuchi, Shigeru Wakida
The authors developed a wearable finger motion measurement system using inertial and geomagnetic sensors. Using this system, motion and posture of the hands and fingers can be measured. However, the joint center and segment axis cannot be accurately measured in a previous study using the sensors. Therefore, the authors proposed a method of estimating the joint center and segment lengths. This method utilizes the fact that the calculation formula of the rotational acceleration in the sensor's coordinate system is the vector product...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28263416/the-effect-of-reward-expectation-on-the-time-course-of-perceptual-decisions
#20
Annalisa Tosoni, Giorgia Committeri, Cinzia Calluso, Gaspare Galati
Perceptual discriminations can be strongly biased by the expected reward for a correct decision but the neural mechanisms underlying this influence are still partially unclear. Using functional magnetic resonance imaging (fMRI) during a task requiring to arbitrarily associate a visual stimulus with a specific action, we have recently shown that perceptual decisions are encoded within the same sensorimotor regions responsible for planning and executing specific motor actions. Here we examined whether these regions additionally encode the amount of expected reward for a perceptual decision...
March 6, 2017: European Journal of Neuroscience
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