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https://www.readbyqxmd.com/read/29779297/cardiac-rhythm-management-devices
#1
Irene Stevenson, Alex Voskoboinik
BACKGROUND: The last decade has seen ongoing evolution and use of cardiac rhythm management devices, including pacemakers, cardiac resynchronisation therapy, implantable cardioverter defibrillators and loop recorders. General practitioners are increasingly involved in follow-up and management of patients with these devices. OBJECTIVE: The aim of this article is to provide an overview of different cardiac rhythm management devices, including their role, implant procedure, post-procedural care, potential complications and follow‑up...
May 2018: Australian journal of general practice
https://www.readbyqxmd.com/read/29779194/patient-accident-fracture-paf-classification-of-acute-distal-radius-fractures-in-adults
#2
G Herzberg, T Galissard, M Burnier
There is not enough evidence in the literature to support the use of any classification system for distal radius fractures (DRF) in adults. However, there is a need for identification of more homogeneous groups of patients with DRF so that the extent of preoperative workup and sophistication of treatment would best match the needs of the patient. The authors propose an innovative method to analyse and stratify acute DRF in adults. A one-page chart includes criteria related to the patient (P), the energy of the accident (A) and the pathology of the fracture (F)...
May 19, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29779065/digital-technologies-in-the-treatment-of-anxiety-recent-innovations-and-future-directions
#3
REVIEW
Joseph Firth, John Torous, Rebekah Carney, Jill Newby, Theodore D Cosco, Helen Christensen, Jerome Sarris
PURPOSE OF REVIEW: This review aims to provide a comprehensive overview of the efficacy, limitations, and future of e-health treatments for anxiety. Within this, we provide detail on "first-generation" e-health approaches, such as computerized therapies. Additionally, we assess the emergence and early efficacy of newer methods of treatment delivery, including smartphone apps and virtual reality interventions, discussing the potential and pitfalls for each. RECENT FINDINGS: There is now substantial clinical research demonstrating the efficacy of internet-delivered cognitive behavioral therapy in the treatment of anxiety...
May 19, 2018: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29778791/evolutionary-transitions-in-controls-reconcile-adaptation-with-continuity-of-evolution
#4
REVIEW
Alexander V Badyaev
Evolution proceeds by accumulating functional solutions, necessarily forming an uninterrupted lineage from past solutions of ancestors to the current design of extant forms. At the population level, this process requires an organismal architecture in which the maintenance of local adaptation does not preclude the ability to innovate in the same traits and their continuous evolution. Representing complex traits as networks enables us to visualize a fundamental principle that resolves tension between adaptation and continuous evolution: phenotypic states encompassing adaptations traverse the continuous multi-layered landscape of past physical, developmental and functional associations among traits...
May 17, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29778663/glp-1-receptor-agonists-and-reduction-of-cardiometabolic-risk-potential-underlying-mechanisms
#5
REVIEW
Manfredi Rizzo, Dragana Nikolic, Angelo Maria Patti, Carlo Mannina, Giuseppe Montalto, Brooke S McAdams, Ali A Rizvi, Francesco Cosentino
Type 2 diabetes mellitus (T2DM) is a metabolic condition with an elevated impact on cardiovascular (CV) risk. The innovative therapeutic approaches for T2DM - incretin-based therapies (IBTs), including glucagon-like peptide 1 (GLP-1) receptor agonists, have become popular and more widely used in recent years. The available scientific data from clinical studies and clinical practice highlights their beyond glucose-lowering effects, which is achieved without any increase in hypoglycaemia. The former effects include reduction in body weight, lipids, blood pressure, inflammatory markers, oxidative stress, endothelial dysfunction, and subclinical atherosclerosis, thus reducing and potentially preventing CV events...
May 17, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29778530/exploiting-bacteriophage-proteomes-the-hidden-biotechnological-potential
#6
REVIEW
Sílvio B Santos, Ana Rita Costa, Carla Carvalho, Franklin L Nóbrega, Joana Azeredo
Bacteriophages encode many distinct proteins for the successful infection of a bacterial host. Each protein plays a specific role in the phage replication cycle, from host recognition, through takeover of the host machinery, and up to cell lysis for progeny release. As the roles of these proteins are being revealed, more biotechnological applications can be anticipated. Phage-encoded proteins are now being explored for the control, detection, and typing of bacteria; as vehicles for drug delivery; and for vaccine development...
May 16, 2018: Trends in Biotechnology
https://www.readbyqxmd.com/read/29778518/an-innovative-medical-school-curriculum-to-address-human-papillomavirus-vaccine-hesitancy
#7
Abigail M Schnaith, Erica M Evans, Caleb Vogt, Andrea M Tinsay, Thomas E Schmidt, Katelyn M Tessier, Britt K Erickson
BACKGROUND: Vaccination rates against Human Papillomavirus (HPV) in the US remain alarmingly low. Physicians can significantly influence a parent's decision to vaccinate their children. However, medical education often lacks training on specific strategies for communicating with vaccine hesitant parents. METHODS: We created an innovative curriculum designed to teach medical students how to address HPV vaccine hesitancy. The curriculum consisted of (1) a presentation on the epidemiology, biology, and disease morbidity associated with HPV, (2) a video that teaches specific communication strategies and (3) role-playing simulations...
May 16, 2018: Vaccine
https://www.readbyqxmd.com/read/29778490/the-molecular-allergology-of-subtropical-grass-pollen
#8
Thina Kailaivasan, Janet M Davies
Grass pollens are amongst the most important aeroallergen sources world-wide triggering allergic rhinoconjunctivitis and asthma in sensitised patients. Much of what we know about the allergen components of grasses is informed by research on pollen of temperate (Pooideae) species that are abundant in the temperate climate zones. However, climate changes are altering the biogeographical distribution as well as timing and allergenicity of grass pollens. This provides an impetus for better understanding of the contribution of subtropical subfamilies of grasses to pollen allergy globally...
May 16, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29778410/paleo-oncology-taking-stock-and-moving-forward
#9
Casey L Kirkpatrick, Roselyn A Campbell, Kathryn J Hunt
This article serves as an introduction to the International Journal of Paleopathology's special issue, Paleo-oncology: Taking Stock and Moving Forward. Reflecting the goals of the special issue, this paper has been designed to provide an overview of the current state of paleo-oncology, to introduce new and innovative paleo-oncological research and ideas, and to serve as a catalyst for future discussions and progress. This paper begins with an overview of the paleo-oncological evidence that can be found in ancient remains, followed by a summary of significant paleo-oncological findings and methodological advances to date...
February 12, 2018: International Journal of Paleopathology
https://www.readbyqxmd.com/read/29778396/how-effective-are-approaches-to-migrant-screening-for-infectious-diseases-in-europe-a-systematic-review
#10
REVIEW
Farah Seedat, Sally Hargreaves, Laura B Nellums, Jing Ouyang, Michael Brown, Jon S Friedland
Rates of migration to Europe, and within Europe, have increased in recent years, with considerable implications for health systems. Migrants in Europe face a disproportionate burden of tuberculosis, HIV, and hepatitis B and C, yet experience a large number of barriers to accessing statutory health care on arrival. A better understanding of how to deliver effective and cost-effective screening, vaccination, and health services to this group is now crucial. We did a systematic review to document and assess the effectiveness and cost-effectiveness of approaches used for infectious diseases screening, and to explore facilitators and barriers experienced by migrants to accessing screening programmes...
May 16, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29778326/new-jbi-policy-emphasizes-substantive-practical-methodological-innovations-for-biomedical-privacy-and-security-papers
#11
EDITORIAL
William A Yasnoff, Edward H Shortliffe
No abstract text is available yet for this article.
May 17, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29778278/new-evidence-of-a-rhythmic-priming-effect-that-enhances-grammaticality-judgments-in-children
#12
Alexander Chern, Barbara Tillmann, Chloe Vaughan, Reyna L Gordon
Musical rhythm and the grammatical structure of language share a surprising number of characteristics that may be intrinsically related in child development. The current study aimed to understand the potential influence of musical rhythmic priming on subsequent spoken grammar task performance in children with typical development who were native speakers of English. Participants (ages 5-8 years) listened to rhythmically regular and irregular musical sequences (within-participants design) followed by blocks of grammatically correct and incorrect sentences upon which they were asked to perform a grammaticality judgment task...
May 16, 2018: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29778267/the-road-to-hepatitis-c-virus-cure-practical-considerations-from-a-health-system-s-perspective
#13
REVIEW
M Cabell Jonas, Bernadette Loftus, Michael A Horberg
Hepatitis C virus infection remains a significant global health problem. Many individuals are unaware of their infection or disease stage. Innovations in care that promote rapid and easy identification of at-risk populations for screening, comprehensive diagnostic screening, and triage to curative direct-acting antiviral medications will accelerate efforts to eradicate hepatitis C.
June 2018: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/29778264/hepatitis-c-virus-diagnosis-and-the-holy-grail
#14
REVIEW
Tanya L Applegate, Emmanuel Fajardo, Jilian A Sacks
The world has embraced the call for global elimination of hepatitis C virus by 2030. The unprecedented speed of therapeutic development and increased access to direct-acting antivirals has made elimination a possibility. We must screen hundreds of millions of people to diagnose and treat those currently infected. Global access to hepatitis C virus diagnostics will be a keystone to success. Key challenges must be overcome and systems optimized to ensure widespread access to existing diagnostics. Although promising technologies may soon transform the landscape, innovative strategies are needed to stimulate investment and accelerate the development of point-of-care hepatitis C virus diagnostics...
June 2018: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/29778256/hepatitis-c-care-in-the-department-of-veterans-affairs-building-a-foundation-for-success
#15
REVIEW
Pamela S Belperio, Maggie Chartier, Rachel I Gonzalez, Angela M Park, David B Ross, Tim R Morgan, Lisa I Backus
The Department of Veterans Affairs (VA) has made significant progress in treating hepatitis C virus, experiencing more than a 75% reduction in veterans remaining to be treated since the availability of oral direct-acting antivirals. Hepatitis C Innovation Teams use lean process improvement and system redesign, resulting in practice models that address gaps in care. The key to success is creative improvements in veteran access to providers, including expanded use of nonphysician providers, video telehealth, and electronic technologies...
June 2018: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/29778175/an-innovative-approach-to-minimize-excess-sludge-production-in-sewage-treatment-using-integrated-bioreactors
#16
Mahesh Mannacharaju, Prabhakaran Natarajan, Arivizhivendhan Kannan Villalan, Madasamy Jothieswari, Swarnalatha Somasundaram, Sekaran Ganesan
The present investigation deals with an application of integrated sequential oxic and anoxic bioreactor (SOABR) and fluidized immobilized cell carbon oxidation (FICCO) reactor for the treatment of domestic wastewater with minimum sludge generation. The performance of integrated SOABR-FICCO system was evaluated on treating the domestic wastewater at hydraulic retention time (HRT) of 3hr and 6hr for 120days at organic loading rate (OLR) of 191±31mg/(L·hr). The influent wastewater was characterized by chemical oxygen demand (COD) 573±93mg/L; biochemical oxygen demand (BOD5 ) 197±35mg/L and total suspended solids (TSS) 450±136mg/L...
May 2018: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29778171/combined-zero-valent-iron-and-hydrogen-peroxide-conditioning-significantly-enhances-the-dewaterability-of-anaerobic-digestate
#17
Qilin Wang, Jing Sun, Kang Song, Xu Zhou, Wei Wei, Dongbo Wang, Guo-Jun Xie, Yanyan Gong, Beibei Zhou
The importance of enhancing sludge dewaterability is increasing due to the considerable impact of excess sludge volume on disposal costs and on overall sludge management. This study presents an innovative approach to enhance dewaterability of anaerobic digestate (AD) harvested from a wastewater treatment plant. The combination of zero valent iron (ZVI, 0-4.0g/g total solids (TS)) and hydrogen peroxide (HP, 0-90mg/g TS) under pH3.0 significantly enhanced the AD dewaterability. The largest enhancement of AD dewaterability was achieved at 18mg HP/g TS and 2...
May 2018: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29778124/paraprosthetic-complications-after-endoprosthesis-replacement-of-pelvis-joint-with-implants
#18
Shalginbay A Baimagambetov, Serik S Balgazarov, Zhanatay K Ramazanov, Yelena A Belan, Ruslan S Abilov, Alexey A Dolgov, Amangol S Balgazarov
PURPOSE: The purpose of the paper is shaping of ideas about possible ways of decreasing complications of the analyzed types of operations and identification of opportunities of the impact on the socio-economic environment among the Afro-American population of USA. The paper demonstrates that the issue of coxofemoral prosthesis is not only a purely medical but also a social problem. In particular, availability of timely aid, as well as insurance in the form of surgery, refer to relevance of the range of problems...
June 2018: Journal of the National Medical Association
https://www.readbyqxmd.com/read/29778095/establishing-an-innovative-carbohydrate-metabolic-pathway-for-efficient-production-of-2-keto-l-gulonic-acid-in-ketogulonicigenium-robustum-initiated-by-intronic-promoters
#19
Cai-Yun Wang, Ye Li, Zi-Wei Gao, Li-Cheng Liu, Meng-Yue Zhang, Tian-Yuan Zhang, Chun-Fu Wu, Yi-Xuan Zhang
BACKGROUND: 2-Keto-L-gulonic acid (2-KGA), the precursor of vitamin C, is currently produced by two-step fermentation. In the second step, L-sorbose is transformed into 2-KGA by the symbiosis system composed of Ketogulonicigenium vulgare and Bacillus megaterium. Due to the different nutrient requirements and the uncertain ratio of the two strains, the symbiosis system significantly limits strain improvement and fermentation optimization. RESULTS: In this study, Ketogulonicigenium robustum SPU_B003 was reported for its capability to grow well independently and to produce more 2-KGA than that of K...
May 19, 2018: Microbial Cell Factories
https://www.readbyqxmd.com/read/29778022/low-cost-composited-accelerants-for-anaerobic-digestion-of-dairy-manure-focusing-on-methane-yield-digestate-utilization-and-energy-evaluation
#20
Chen Zhang, Sining Yun, Xue Li, Ziqi Wang, Hongfei Xu, Tingting Du
To improve the methane yield and digestate utilization of anaerobic digestion (AD), low-cost composited accelerants consisting of urea (0.2-0.5%), bentonite (0.5-0.8%), active carbon (0.6-0.9%), and plant ash (0.01-0.3%) were designed and tested in batch experiments. Total biogas yield (485.7-681.9 mL/g VS) and methane content (63.0-66.6%) were remarkably enhanced in AD systems by adding accelerants compared to those of control group (361.9 mL/g VS, 59.4%). Composited accelerant addition led to the highest methane yield (454...
May 11, 2018: Bioresource Technology
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