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https://www.readbyqxmd.com/read/28343169/a-bayesian-semiparametric-factor-analysis-model-for-subtype-identification
#1
Jiehuan Sun, Joshua L Warren, Hongyu Zhao
Disease subtype identification (clustering) is an important problem in biomedical research. Gene expression profiles are commonly utilized to infer disease subtypes, which often lead to biologically meaningful insights into disease. Despite many successes, existing clustering methods may not perform well when genes are highly correlated and many uninformative genes are included for clustering due to the high dimensionality. In this article, we introduce a novel subtype identification method in the Bayesian setting based on gene expression profiles...
March 25, 2017: Statistical Applications in Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28343143/impact-of-rivaroxaban-on-point-of-care-assays
#2
Pierre Fontana, Lorenzo Alberio, Anne Angelillo-Scherrer, Lars M Asmis, Wolfgang Korte, Adriana Mendez, Pirmin Schmid, Hans Stricker, Jan-Dirk Studt, Dimitrios A Tsakiris, Walter A Wuillemin, Michael Nagler
BACKGROUND: Point-of-care testing (POCT) is regularly used to assess haemostasis in various clinical settings. The impact of rivaroxaban on those POCT is still elusive. We aimed to study the effects of rivaroxaban on most commonly used POCT assays. METHODS: Blood samples were taken before, 3h, and 24h after administration of 20mg rivaroxaban to 20 healthy volunteers as part of a prospective, multicenter validation study (clinicaltrials.govNCT01710267). Blood samples were analysed with thromboelastometry (ROTEM®), two platelet function assays (INNOVANCE® PFA-200 and Multiplate®), and the CoaguChek® XS...
March 21, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28342917/science-of-health-care-delivery-as-a-first-step-to-advance-undergraduate-medical-education-a-multi-institutional-collaboration
#3
Stephanie R Starr, Darcy A Reed, Alison Essary, William Hueston, C Daniel Johnson, Natalie Landman, John Meurer, Bonnie Miller, Greg Ogrinc, Elizabeth M Petty, John Raymond, William Riley, Sherine Gabriel, Cheryl Maurana
Physicians must possess knowledge and skills to address the gaps facing the US health care system. Educators advocate for reform in undergraduate medical education (UME) to align competencies with the Triple Aim. In 2014, five medical schools and one state university began collaborating on these curricular gaps. The authors report a framework for the Science of Health Care Delivery (SHCD) using six domains and highlight curricular examples from each school. They describe three challenges and strategies for success in implementing SHCD curricula...
March 22, 2017: Healthcare
https://www.readbyqxmd.com/read/28342675/the-digital-heart-manual-a-pilot-study-of-an-innovative-cardiac-rehabilitation-programme-developed-for-and-with-users
#4
C Deighan, L Michalova, C Pagliari, J Elliott, L Taylor, H Ranaldi
OBJECTIVE: Patients are seeking greater choice and flexibility in how they engage with self-management programmes. While digital innovations offer opportunities to deliver supportive interventions to patients undergoing cardiac rehabilitation little is known about how accessible, useful and acceptable they are for this group. This project developed a digital version of a leading evidenced cardiac rehabilitation programme, the Heart Manual (HM). The prototype was developed and evaluated iteratively in collaboration with end users...
March 10, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28342472/-the-room-of-errors-a-fun-learning-tool
#5
Émilie Estival, Justine Sinoquet, Franck Cluzel
Simulation in health care, a source of innovative pedagogical developments, is particularly well-suited to the training of nursing teams. It enables them to acquire or reinforce their knowledge, without any risk for the patients, in a calm and reassuring environment. In psychiatry in particular, the use of a room of errors constitutes a useful learning tool for professionals.
March 2017: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/28342350/challenges-for-tree-officers-to-enhance-the-provision-of-regulating-ecosystem-services-from-urban-forests
#6
Helen J Davies, Kieron J Doick, Malcolm D Hudson, Kate Schreckenberg
Urbanisation and a changing climate are leading to more frequent and severe flood, heat and air pollution episodes in Britain's cities. Interest in nature-based solutions to these urban problems is growing, with urban forests potentially able to provide a range of regulating ecosystem services such as stormwater attenuation, heat amelioration and air purification. The extent to which these benefits are realized is largely dependent on urban forest management objectives, the availability of funding, and the understanding of ecosystem service concepts within local governments, the primary delivery agents of urban forests...
March 21, 2017: Environmental Research
https://www.readbyqxmd.com/read/28342320/mitigating-hypoxic-stress-on-pancreatic-islets-via-in-situ-oxygen-generating-biomaterial
#7
Maria M Coronel, Ryan Geusz, Cherie L Stabler
A major obstacle in the survival and efficacy of tissue engineered transplants is inadequate oxygenation, whereby unsupportive oxygen tensions result in significant cellular dysfunction and death within the implant. In a previous report, we developed an innovative oxygen generating biomaterial, termed OxySite, to provide supportive in situ oxygenation to cells and prevent hypoxia-induced damage. Herein, we explored the capacity of this biomaterial to mitigate hypoxic stress in both rat and nonhuman primate pancreatic islets by decreasing cell death, supporting metabolic activity, sustaining aerobic metabolism, preserving glucose responsiveness, and decreasing the generation of inflammatory cytokines...
March 18, 2017: Biomaterials
https://www.readbyqxmd.com/read/28340349/structure-reveals-mechanisms-of-viral-suppressors-that-intercept-a-crispr-rna-guided-surveillance-complex
#8
Saikat Chowdhury, Joshua Carter, MaryClare F Rollins, Sarah M Golden, Ryan N Jackson, Connor Hoffmann, Lyn'Al Nosaka, Joseph Bondy-Denomy, Karen L Maxwell, Alan R Davidson, Elizabeth R Fischer, Gabriel C Lander, Blake Wiedenheft
Genetic conflict between viruses and their hosts drives evolution and genetic innovation. Prokaryotes evolved CRISPR-mediated adaptive immune systems for protection from viral infection, and viruses have evolved diverse anti-CRISPR (Acr) proteins that subvert these immune systems. The adaptive immune system in Pseudomonas aeruginosa (type I-F) relies on a 350 kDa CRISPR RNA (crRNA)-guided surveillance complex (Csy complex) to bind foreign DNA and recruit a trans-acting nuclease for target degradation. Here, we report the cryo-electron microscopy (cryo-EM) structure of the Csy complex bound to two different Acr proteins, AcrF1 and AcrF2, at an average resolution of 3...
March 23, 2017: Cell
https://www.readbyqxmd.com/read/28340317/opportunities-for-crash-and-injury-reduction-a-multi-harm-approach-for-crash-data-analysis
#9
Ann Mallory, Allison Kender, Kevin Moorhouse
OBJECTIVE: A multi-harm approach for analyzing crash and injury data was developed for the ultimate purpose of getting a richer picture of motor vehicle crash outcomes identifying research opportunities in crash safety. METHODS: Methods were illustrated using a retrospective analysis of 69,597 occupant cases from NASS CDS (National Automotive Sampling System Crashworthiness Data System) from 2005 to 2015. Occupant cases were analyzed by frequency and severity of outcome: fatality, injury by AIS (Abbreviated Injury Scale), number of cases, attributable fatality, disability, and injury costs...
March 24, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28340128/crossing-the-health-it-chasm-considerations-and-policy-recommendations-to-overcome-current-challenges-and-enable-value-based-care
#10
Julia Adler-Milstein, Peter J Embi, Blackford Middleton, Indra Neil Sarkar, Jeff Smith
While great progress has been made in digitizing the US health care system, today's health information technology (IT) infrastructure remains largely a collection of systems that are not designed to support a transition to value-based care. In addition, the pursuit of value-based care, in which we deliver better care with better outcomes at lower cost, places new demands on the health care system that our IT infrastructure needs to be able to support. Provider organizations pursuing new models of health care delivery and payment are finding that their electronic systems lack the capabilities needed to succeed...
March 15, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28340092/community-based-effectiveness-trials-as-a-means-to-disseminate-evidence-based-and-culturally-responsive-behavioral-health-interventions
#11
Flavio F Marsiglia, Patricia Dustman, Mary Harthun, Chelsea Coyne Ritland, Adriana Umaña-Taylor
This article adds to the existing knowledge about innovative community-based approaches used to reduce and eliminate behavioral health disparities. Special attention is given to culturally appropriate interventions that increase access to care and that improve the quality of behavioral health services across different geographic regions and communities. Effectiveness trials are presented as appropriate tools to translate existing efficacious interventions into real-world settings. This article describes how to transition from efficacy to effectiveness, including factors essential to consider from the perspectives of university-based research teams and community-based organizations (CBOs)...
March 14, 2017: Health & Social Work
https://www.readbyqxmd.com/read/28339775/mining-non-lattice-subgraphs-for-detecting-missing-hierarchical-relations-and-concepts-in-snomed-ct
#12
Licong Cui, Wei Zhu, Shiqiang Tao, James T Case, Olivier Bodenreider, Guo-Qiang Zhang
Objective: Quality assurance of large ontological systems such as SNOMED CT is an indispensable part of the terminology management lifecycle. We introduce a hybrid structural-lexical method for scalable and systematic discovery of missing hierarchical relations and concepts in SNOMED CT. Material and Methods: All non-lattice subgraphs (the structural part) in SNOMED CT are exhaustively extracted using a scalable MapReduce algorithm. Four lexical patterns (the lexical part) are identified among the extracted non-lattice subgraphs...
February 19, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28339216/embarking-on-a-chemical-space-odyssey
#13
Shiao Y Chow, Adam Nelson
The chemical space explored in drug discovery programs is restricted by a narrow reaction toolkit and the frequent failure of even these reactions with polar and functionalized substrates. Recently, high-throughput reaction optimization has been integrated into discovery workflows, thereby increasing the value of specific reaction classes in the toolkit. It is likely that high-throughput experimentation will enable expansion of the synthetic chemistry that is widely exploited in discovery, thereby increasing innovation in medicinal chemistry...
March 24, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28339207/innovation-s-mean-free-path
#14
John R Yates
No abstract text is available yet for this article.
March 24, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28339193/3d-printing-techniques-in-environmental-science-and-engineering-will-bring-new-innovation
#15
Ligang Hu, Guibin Jiang
No abstract text is available yet for this article.
March 24, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28338852/the-growth-of-biostatistics-and-estimation-of-cancer-risk-estimates-past-current-and-future-challenges
#16
Dale L Preston, Daniel O Stram
There has been a long process of growth and development of statistical approaches to the analysis of cancer incidence and mortality data obtained from the follow-up of radiation exposed populations. The challenges of radiation risk analysis provided impetus for innovative statistical methods, including, the inception and continued improvement of hazard rate regression methods. Key statistical contributions that improved cancer risk estimation include statistical advances pertaining to the measurement error problem...
March 2, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28338586/towards-microsurgical-correction-of-cleft-lip-ex-utero-via-restoration-of-craniofacial-developmental-programs
#17
Xue Dong, Wilmina N Landford, James Hart, Maurizio Risolino, Omer Kaymakcalan, Julia Jin, Yoshiko Toyoda, Elisabetta Ferretti, Licia Selleri, Jason A Spector
BACKGROUND: Cleft Lip with or without Palate (CL/P) is present in approximately 1 in 500-700 live births, representing the most common congenital craniofacial anomaly. Previously, we developed a unique murine model with compound Pbx deficiency that exhibits fully penetrant CL/P. To investigate the possibility of tissue repair at an early gestational stage, we designed a minimally invasive surgical approach suitable for intrauterine repair using Wnt9b-soaked collagen microspheres to restore craniofacial developmental programs for cleft correction...
March 3, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28338498/challenge-of-progressive-multiple-sclerosis-therapy
#18
Alan J Thompson
PURPOSE OF REVIEW: Understanding the mechanisms underlying progression in multiple sclerosis (MS) and identifying appropriate therapeutic targets is a key challenge facing the MS community. This challenge has been championed internationally by organizations such as the Progressive MS Alliance, which has raised the profile of progressive MS and identified the key obstacles to treatment. This review will outline the considerable progress against these challenges. RECENT FINDINGS: New insights into mechanisms underlying progression have opened up potential therapeutic opportunities...
March 23, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28338345/challenges-and-driving-forces-for-business-plans-in-biobanking
#19
Tanja Macheiner, Berthold Huppertz, Michaela Bayer, Karine Sargsyan
BACKGROUND: Due to increased utilization of biospecimens for research and emergence of new technologies, the availability and quality of biospecimens and their collection are coming more and more into focus. However, the long-term economic situation of biobanks is still mostly unclear. Also, the common sustainable utilization of various international biobanks is challenging due to local differences in sample processing, law and ethics. AIM: This article discusses possible strategies to achieve a sustainable utilization of biospecimens as part of the business plan of biobanks...
March 24, 2017: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/28337847/efficacy-of-environmental-and-acceptance-based-enhancements-to-behavioral-weight-loss-treatment-the-enact-trial
#20
Meghan L Butryn, Evan M Forman, Michael R Lowe, Amy A Gorin, Fengqing Zhang, Katherine Schaumberg
OBJECTIVE: This study was designed to compare weight loss through a traditional behavioral treatment (BT) approach that integrated skills for managing the obesogenic food environment (BT + E) with an approach that integrated environmental and acceptance-based skills (BT + EA). Moderators were examined as an exploratory aim. METHODS: Adults (N = 283) were randomly assigned to treatment condition and provided with 26 group-based sessions over the course of 12 months...
March 23, 2017: Obesity
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