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https://www.readbyqxmd.com/read/29736249/activation-of-disease-resistance-against-botryosphaeria-dothidea-by-downregulating-the-expression-of-mdsyp121-in-apple
#1
Xiaowen He, Yanhong Huo, Xiuxia Liu, Qianqian Zhou, Shouqian Feng, Xiang Shen, Baohua Li, Shujing Wu, Xuesen Chen
In plants, the vesicle fusion process plays a vital role in pathogen defence. However, the importance of the vesicle fusion process in apple ring rot has not been studied. Here, we isolated and characterised the apple syntaxin gene MdSYP121 . Silencing the MdSYP121 gene in transgenic apple calli increased tolerance to Botryosphaeria dothidea infection; this increased tolerance was correlated with salicylic acid (SA) synthesis-related and signalling-related gene transcription. In contrast, overexpressing MdSYP121 in apple calli resulted in the opposite phenotypes...
2018: Horticulture Research
https://www.readbyqxmd.com/read/29734491/oxygenation-sensitive-cardiovascular-magnetic-resonance-in-hypertensive-heart-disease-with-left-ventricular-myocardial-hypertrophy-and-non-left-ventricular-myocardial-hypertrophy-insight-from-altered-mechanics-and-cardiac-bold-imaging
#2
Bing-Hua Chen, Rui Wu, Dong-Aolei An, Ruo-Yang Shi, Qiu-Ying Yao, Qing Lu, Jiani Hu, Meng Jiang, James Deen, Ankush Chandra, Jian-Rong Xu, Lian-Ming Wu
BACKGROUND: BOLD (blood oxygen level dependent) MRI can detect regional condition of myocardial oxygen supply and demand by means of paramagnetic properties. PURPOSE: Noninvasive assessment of myocardial oxygenation by BOLD MRI in hypertensive patients with hypertension (HTN) left ventricular myocardial hypertrophy (LVMH) and HTN non-LVMH and its correlation with myocardial mechanics were performed. STUDY TYPE: Prospective. POPULATION: Twenty patients with HTN LVMH, 21 patients with HTN non-LVMH, and 23 normotensive controls were enrolled...
May 7, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29704517/duoxa1-mediated-ros-production-promotes-cisplatin-resistance-by-activating-atr-chk1-pathway-in-ovarian-cancer
#3
Yunxiao Meng, Chi-Wei Chen, Mingo M H Yung, Wei Sun, Jing Sun, Zhuqing Li, Jing Li, Zongzhu Li, Wei Zhou, Stephanie S Liu, Annie N Y Cheung, Hextan Y S Ngan, John C Braisted, Yan Kai, Weiqun Peng, Alexandros Tzatsos, Yiliang Li, Zhijun Dai, Wei Zheng, David W Chan, Wenge Zhu
The acquisition of resistance is a major obstacle to the clinical use of platinum drugs for ovarian cancer treatment. Increase of DNA damage response is one of major mechanisms contributing to platinum-resistance. However, how DNA damage response is regulated in platinum-resistant ovarian cancer cells remains unclear. Using quantitative high throughput combinational screen (qHTCS) and RNA-sequencing (RNA-seq), we show that dual oxidase maturation factor 1 (DUOXA1) is overexpressed in platinum-resistant ovarian cancer cells, resulting in over production of reactive oxygen species (ROS)...
April 25, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29695812/skeletal-muscle-phosphatidylcholine-and-phosphatidylethanolamine-respond-to-exercise-and-influence-insulin-sensitivity-in-men
#4
Sindre Lee, Frode Norheim, Hanne L Gulseth, Torgrim M Langleite, Andreas Aker, Thomas E Gundersen, Torgeir Holen, Kåre I Birkeland, Christian A Drevon
Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) composition in skeletal muscle have been linked to insulin sensitivity. We evaluated the relationships between skeletal muscle PC:PE, physical exercise and insulin sensitivity. We performed lipidomics and measured PC and PE in m. vastus lateralis biopsies obtained from 13 normoglycemic normal weight men and 13 dysglycemic overweight men at rest, immediately after 45 min of cycling at 70% maximum oxygen uptake, and 2 h post-exercise, before as well as after 12 weeks of combined endurance- and strength-exercise intervention...
April 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29693300/adaptive-population-divergence-and-directional-gene-flow-across-steep-elevational-gradients-in-a-climate-sensitive-mammal
#5
Matthew D Waterhouse, Liesl P Erb, Erik A Beever, Michael A Russello
The ecological effects of climate change have been shown in most major taxonomic groups; however, the evolutionary consequences are less well-documented. Adaptation to new climatic conditions offers a potential long-term mechanism for species to maintain viability in rapidly changing environments, but mammalian examples remain scarce. The American pika (Ochotona princeps) has been impacted by recent climate-associated extirpations and range-wide reductions in population sizes, establishing it as a sentinel mammalian species for climate change...
April 25, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29679757/molecular-characterization-of-cu-zn-sod-gene-in-asian-clam-corbicula-fluminea-and-mrna-expression-and-enzymatic-activity-modulation-induced-by-metals
#6
Xie Yanhai, Chen Hongbing, Zheng Shuangyan, Zhang Xiali, Mu Songniu
The copper/zinc superoxide dismutase (Cu/Zn SOD) could effectively eliminate reactive oxygen species (ROS). In this study, the cDNA sequence of Cu/Zn SOD from Corbicula fluminea (designated as CfCu/Zn SOD) was cloned by the rapid amplification of cDNA ends (RACE) approaches. The full-length cDNA of CfCu/Zn SOD was of 1288 bp, including a 465 bp ORF encoding a protein of 154 amino acids. Two SOD family signatures were identified in CfCu/Zn SOD amino acids sequence. Multiple sequence alignments indicated that CfCu/Zn SOD amino acid sequences exhibited high similarities to those of other species...
April 18, 2018: Gene
https://www.readbyqxmd.com/read/29662499/nad-kinases-metabolic-targets-controlling-redox-co-enzymes-and-reducing-power-partitioning-in-plant-stress-and-development
#7
REVIEW
Bin-Bin Li, Xiang Wang, Li Tai, Tian-Tian Ma, Abdullah Shalmani, Wen-Ting Liu, Wen-Qiang Li, Kun-Ming Chen
NAD(H) and NADP(H) are essential co-enzymes which dominantly control a number of fundamental biological processes by acting as reducing power and maintaining the intracellular redox balance of all life kingdoms. As the only enzymes that catalyze NAD(H) and ATP to synthesize NADP(H), NAD Kinases (NADKs) participate in many essential metabolic reactions, redox sensitive regulation, photosynthetic performance and also reactive oxygen species (ROS) homeostasis of cells and therefore, play crucial roles in both development and stress responses of plants...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29649874/structural-dynamics-of-the-oxygen-evolving-complex-of-photosystem-ii-in-water-splitting-action
#8
Andrew J Wilson, Prashant K Jain
Oxygenic photosynthesis in nature occurs via water splitting catalyzed by the oxygen evolving complex (OEC) of photo-system II. To split water, the OEC cycles through a sequence of oxidation states (Si , i = 0-4), the structural mechanism of which is not fully understood under physiological conditions. We monitored the OEC in visible light-driven water-splitting action by using in-situ, aqueous-environment surface-enhanced Raman scattering (SERS). In the unexplored low-frequency region of SERS, we found dynamic vibrational signatures of water binding and splitting...
April 12, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29599910/developing-a-genetic-signature-to-predict-drug-response-in-ovarian-cancer
#9
Stephen Hyter, Jeff Hirst, Harsh Pathak, Ziyan Y Pessetto, Devin C Koestler, Rama Raghavan, Dong Pei, Andrew K Godwin
There is a lack of personalized treatment options for women with recurrent platinum-resistant ovarian cancer. Outside of bevacizumab and a group of poly ADP-ribose polymerase inhibitors, few options are available to women that relapse. We propose that efficacious drug combinations can be determined via molecular characterization of ovarian tumors along with pre-established pharmacogenomic profiles of repurposed compounds. To that end, we selectively performed multiple two-drug combination treatments in ovarian cancer cell lines that included reactive oxygen species inducers and HSP90 inhibitors...
March 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29565279/overexpression-of-a-sbp-box-gene-vpsbp16-from-chinese-wild-vitis-species-in-arabidopsis-improves-salinity-and-drought-stress-tolerance
#10
Hongmin Hou, Hui Jia, Qin Yan, Xiping Wang
Salinity and drought are two major abiotic stresses that limit grape productivity. Responses to stress in grape are known to be regulated by several families of transcription factors. However, little is known about the role of grape Squamosa promoter binding protein (SBP)-box transcription factor genes in response to abiotic stress. To better understand the functions of the grape SBP-box genes in abiotic stress tolerance, a full-length complementary DNA (cDNA) sequence of the putative SBP-box transcription factor gene, VpSBP16 was amplified from Chinese wild grapevine Vitis pseudoreticulata clone "Baihe-35-1"...
March 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29535165/endoplasmic-reticulum-protein-txndc5-augments-myocardial-fibrosis-by-facilitating-extracellular-matrix-protein-folding-and-redox-sensitive-cardiac-fibroblast-activation
#11
Ying-Chun Shih, Chao-Ling Chen, Yan Zhang, Rebecca L Mellor, Evelyn M Kanter, Yun Fang, Hua-Chi Wang, Chen-Ting Hung, Jing-Yi Nong, Hui-Ju Chen, Tzu-Han Lee, Yi-Shuan Tseng, Chiung-Nien Chen, Chau-Chung Wu, Shuei-Liong Lin, Kathryn A Yamada, Jeanne M Nerbonne, Kai-Chien Yang
RATIONALE: Cardiac fibrosis plays a critical role in the pathogenesis of heart failure. Excessive accumulation of extracellular matrix (ECM) resulting from cardiac fibrosis impairs cardiac contractile function and increases arrhythmogenicity. Current treatment options for cardiac fibrosis, however, are limited, and there is a clear need to identify novel mediators of cardiac fibrosis to facilitate the development of better therapeutics. Exploiting coexpression gene network analysis on RNA sequencing data from failing human heart, we identified TXNDC5 (thioredoxin domain containing 5), a cardiac fibroblast (CF)-enriched endoplasmic reticulum protein, as a potential novel mediator of cardiac fibrosis, and we completed experiments to test this hypothesis directly...
April 13, 2018: Circulation Research
https://www.readbyqxmd.com/read/29517835/consistency-of-multiple-renal-functional-mri-measurements-over-18-months
#12
Lu-Ping Li, Jon Thacker, Wei Li, Huan Tan, Chi Wang, Orly Kohn, Stuart Sprague, Pottumarthi Prasad
BACKGROUND: Identification of patients with progressive chronic kidney disease (CKD) and those likely to respond to candidate therapeutics is urgently needed. Functional MRI measurements have shown promise. However, knowledge about the consistency of the measurements is essential to conduct longitudinal studies. PURPOSE/HYPOTHESIS: To investigate the consistency of repeated functional MRI measurements in healthy subjects. STUDY TYPE: Prospective, longitudinal study...
March 8, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29486301/haplogroup-j-mitogenomes-are-the-most-sensitive-to-the-pesticide-rotenone-relevance-for-human-diseases
#13
Daniela Strobbe, Leonardo Caporali, Luisa Iommarini, Alessandra Maresca, Monica Montopoli, Andrea Martinuzzi, Alessandro Achilli, Anna Olivieri, Antonio Torroni, Valerio Carelli, Anna Ghelli
There is growing evidence that the sequence variation of mitochondrial DNA (mtDNA), which clusters in population- and/or geographic-specific haplogroups, may result in functional effects that, in turn, become relevant in disease predisposition or protection, interaction with environmental factors and ultimately in modulating longevity. To unravel functional differences between mtDNA haplogroups we here employed transmitochondrial cytoplasmic hybrid cells (cybrids) grown in galactose medium, a culture condition that forces oxidative phosphorylation, and in the presence of rotenone, the classic inhibitor of respiratory Complex I...
June 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29479359/a-rice-cpyc-type-glutaredoxin-osgrx20-in-protection-against-bacterial-blight-methyl-viologen-and-salt-stresses
#14
Xi Ning, Yao Sun, Changchun Wang, Weilin Zhang, Meihao Sun, Haitao Hu, Jianzhong Liu, Ling Yang
Glutaredoxins (GRXs) belong to the antioxidants involved in the cellular stress responses. In spite of the identification 48 GRX genes in rice genomes, the biological functions of most of them remain unknown. Especially, the biological roles of members of GRX family in disease resistance are still lacking. Our proteomic analysis found that OsGRX20 increased by 2.7-fold after infection by bacterial blight. In this study, we isolated and characterized the full-length nucleotide sequences of the rice OsGRX20 gene, which encodes a GRX family protein with CPFC active site of CPYC-type class...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29437791/a-phase-i-study-of-cpi-613-in-combination-with-high-dose-cytarabine-and-mitoxantrone-for-relapsed-or-refractory-acute-myeloid-leukemia
#15
Timothy S Pardee, Rebecca G Anderson, Kristin M Pladna, Scott Isom, Lais P Ghiraldeli, Lance D Miller, Jeff W Chou, Guangxu Jin, Wei Zhang, Leslie R Ellis, Dmitriy Berenzon, Dianna S Howard, David D Hurd, Megan Manuel, Sarah Dralle, Susan Lyerly, Bayard L Powell
Purpose: CPI-613, a lipoate analogue that inhibits pyruvate dehydrogenase (PDH) and α-ketogluterate dehydrogenase (KGDH), has activity in patients with myeloid malignancies. This study explored the role of mitochondrial metabolism in chemotherapy response and determined the MTD, efficacy, and safety of CPI-613 combined with high-dose cytarabine and mitoxantrone in patients with relapsed or refractory acute myeloid leukemia. Experimental Design: The role of mitochondrial response to chemotherapy was assessed in cell lines and animal models...
May 1, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29402501/hoxa4-hoxb3-gene-expression-signature-as-a-biomarker-of-recurrence-in-patients-with-high-grade-serous-ovarian-cancer-following-primary-cytoreductive-surgery-and-first-line-adjuvant-chemotherapy
#16
Katherine R Miller, Jai N Patel, Qing Zhang, Eric J Norris, James Symanowski, Chad Michener, Jalid Sehouli, Ioana Braicu, Darla D Destephanis, Ashley P Sutker, Wendell Jones, Chad A Livasy, Charles Biscotti, Ram N Ganapathi, David L Tait, Mahrukh K Ganapathi
OBJECTIVES: Aberrant homeobox (HOX) gene expression is reported in high-grade serous ovarian carcinoma (HGSOC), however, its prognostic significance remains unclear. METHODS: HOX genes associated with progression-free survival (PFS) in a discovery cohort of primary HGSOC samples with RNA sequencing data, and those previously reported to be associated with clinical outcomes, were selected for qPCR testing in an independent training cohort of primary HGSOC samples (n=71)...
April 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29389985/multiband-multi-echo-simultaneous-asl-bold-for-task-induced-functional-mri
#17
Alexander D Cohen, Andrew S Nencka, Yang Wang
Typical simultaneous blood oxygenation-level dependent (BOLD) and arterial spin labeling (ASL) sequences acquire two echoes, one perfusion-sensitive and one BOLD-sensitive. However, for ASL, spatial resolution and brain coverage are limited due to the T1 decay of the labeled blood. This study applies a sequence combining a multiband acquisition with four echoes for simultaneous BOLD and pseudo-continuous ASL (pCASL) echo planar imaging (MBME ASL/BOLD) for block-design task-fMRI. A multiband acceleration of four was employed to increase brain coverage and reduce slice-timing effects on the ASL signal...
2018: PloS One
https://www.readbyqxmd.com/read/29373572/intraspecific-variation-in-oxidative-stress-tolerance-in-a-model-cnidarian-differences-in-peroxide-sensitivity-between-and-within-populations-of-nematostella-vectensis
#18
Lauren E Friedman, Thomas D Gilmore, John R Finnerty
Nematostella vectensis is a member of the phylum Cnidaria, a lineage that includes anemones, corals, hydras, and jellyfishes. This estuarine anemone is an excellent model system for investigating the evolution of stress tolerance because it is easy to collect in its natural habitat and to culture in the laboratory, and it has a sequenced genome. Additionally, there is evidence of local adaptation to environmental stress in different N. vectensis populations, and abundant protein-coding polymorphisms have been identified, including polymorphisms in proteins that are implicated in stress responses...
2018: PloS One
https://www.readbyqxmd.com/read/29369415/cross-vendor-harmonization-of-t2-relaxation-under-spin-tagging-trust-mri-for-the-assessment-of-cerebral-venous-oxygenation
#19
Dengrong Jiang, Peiying Liu, Yang Li, Deng Mao, Cuimei Xu, Hanzhang Lu
PURPOSE: Cerebral venous oxygenation (Yv ) is an important physiological parameter and has potential clinical application in many brain diseases. T2 -relaxation-under-spin-tagging (TRUST) is a commonly used MRI method to measure Yv . Harmonization of this technique across MRI vendors is important for dissemination and multicenter studies of brain oxygenation and metabolism as a disease biomarker. METHODS: TRUST pulse sequence components and imaging parameters were carefully matched between two major MRI vendors, Philips and Siemens...
January 25, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29357200/improved-detection-of-fmri-activation-in-the-cerebellum-at-7t-with-dielectric-pads-extending-the-imaging-region-of-a-commercial-head-coil
#20
Manushka V Vaidya, Mariana Lazar, Cem M Deniz, Gillian G Haemer, Gang Chen, Mary Bruno, Daniel K Sodickson, Riccardo Lattanzi, Christopher M Collins
BACKGROUND: There is growing interest in detecting cerebro-cerebellar circuits, which requires adequate blood oxygenation level dependent contrast and signal-to-noise ratio (SNR) throughout the brain. Although 7T scanners offer increased SNR, coverage of commercial head coils is currently limited to the cerebrum. PURPOSE: To improve cerebellar functional MRI (fMRI) at 7T with high permittivity material (HPM) pads extending the sensitivity of a commercial coil. STUDY TYPE: Simulations were used to determine HPM pad configuration and assess radiofrequency (RF) safety...
January 21, 2018: Journal of Magnetic Resonance Imaging: JMRI
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