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https://www.readbyqxmd.com/read/28930586/drug-repurposing-approaches-to-fight-dengue-virus-infection-and-related-diseases
#1
Lorenzo Botta, Mirko Rivara, Valentina Zuliani, Marco Radi
Dengue is a mosquito-borne viral disease caused by four antigenically distinct serotypes of Dengue Virus (DENV), namely DENV1-4 and is currently considered the most important arthropod-born viral disease in the world. An effective antiviral therapy to treat Dengue Virus infection is still missing and a number of replicative cycle inhibitors are currently under study. Considering the rapid spreading of DENV and the common timeframe required for bringing a new drug on the market, the repurposing of approved drugs used for different diseases to identify novel inhibitors of this pathogen represents an attractive approach for a rapid therapeutic intervention...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930536/reca-a-universal-drug-target-in-pathogenic-bacteria
#2
Athanasia Pavlopoulou
The spread of bacterial infectious diseases due to the development of resistance to antibiotic drugs in pathogenic bacteria is an emerging global concern. Therefore, the efficacious management and prevention of bacterial infections are major public health challenges. RecA is a pleiotropic recombinase protein that has been demonstrated to be implicated strongly in the bacterial drug resistance, survival and pathogenicity. In this minireview, RecA's role in the development of antibiotic resistance and its potential as an antimicrobial drug target are discussed...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930088/comparison-of-pcr-methods-for-the-detection-of-genetic-variants-of-carp-edema-virus
#3
Mikolaj Adamek, Marek Matras, Verena Jung-Schroers, Felix Teitge, Max Heling, Sven M Bergmann, Michal Reichert, Keith Way, David M Stone, Dieter Steinhagen
The infection of common carp and its ornamental variety, koi, with the carp edema virus (CEV) is often associated with the occurrence of a clinical disease called 'koi sleepy disease'. The disease may lead to high mortality in both koi and common carp populations. To prevent further spread of the infection and the disease, a reliable detection method for this virus is required. However, the high genetic variability of the CEV p4a gene used for PCR-based diagnostics could be a serious obstacle for successful and reliable detection of virus infection in field samples...
September 20, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28930087/detection-of-amphibian-chytrid-fungus-on-waterfowl-integument-in-natural-settings
#4
Shane M Hanlon, Jerad R Henson, Jacob L Kerby
The chytrid fungus Batrachochytrium dendrobatidis (Bd), the causal agent of the amphibian disease chytridiomycosis, has spread at an alarming rate since its discovery. Bd was initially thought to only infect keratinizing epithelial cells in amphibians, a core component of amphibian skin. However, recent studies have detected Bd on the integument of non-amphibian hosts. We conducted a survey of 3 duck species (gadwalls, green-winged teals, and mallards) to determine whether Bd DNA could be found on their feet...
September 20, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28930085/importation-of-cyhv-2-infected-goldfish-into-the-netherlands
#5
Takafumi Ito, Jun Kurita, Olga L M Haenen
Cyprinid herpesvirus 2 (CyHV-2) is known as the causative agent of herpesviral haematopoietic necrosis in goldfish Carassius auratus auratus. However, the virus has also been detected in Prussian carp C. gibelio and crucian carp C. carassius from European and Asian countries. To prevent spread of the causative virus to other areas, investigation of the risk factors of spread of this virus is important. In this study, 8 batches of goldfish imported into the Netherlands by airfreight from Asia and the Middle East were investigated for the presence of the virus...
September 20, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28929056/clinico-pathological-profile-of-deep-neck-space-infection-a-prospective-study
#6
Rumpa Das, Gorakh Nath, Anupam Mishra
Deep neck space infections (DNI) has been a common and serious disease, involving several spaces created by planes of greater and lesser resistance between the fascial layers of the neck. Infection of deep neck space has been dangerous due to its potential ease of spread from one space to other space, associated sepsis and upper airway obstruction. This prospective study was done in 45 patients of DNI over a period of 1 year. Patients with age of 1 month to 80 years of both the sexes were included. Patient's particular, clinical presentation and associated co-morbid conditions, physical examination, routine laboratory investigations and radiological investigations were analyzed...
September 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28928941/computational-design-of-molecular-motors-as-nanocircuits-in-leishmaniasis
#7
Dipali Kosey, Shailza Singh
Cutaneous leishmaniasis is the most common form of lesihmaniasis, caused by Leishmania major and is spread by the bite of a sandfly .This species infects the macrophages and dendritic cells Due to multi-drug resistance, there is a need for a new therapeutic technique. Recently, a novel molecular motor of Leishmania, Myosin XXI, was classified and characterized. In addition, the drug resistance in this organism has been linked with the overexpression of ABC transporters. Systems biology aims to study the simulation and modeling of natural biological systems whereas synthetic biology deals with building novel and artificial biological parts and devices  Together they have contributed enormously to drug discovery, vaccine design and development, infectious disease detection and diagnostics...
2017: F1000Research
https://www.readbyqxmd.com/read/28928720/potential-risk-areas-of-aedes-albopictus-in-south-eastern-iran-a-vector-of-dengue-fever-zika-and-chikungunya
#8
Jalil Nejati, Rubén Bueno-Marí, Francisco Collantes, Ahmad A Hanafi-Bojd, Hassan Vatandoost, Zabihollah Charrahy, Seyed M Tabatabaei, Mohammad R Yaghoobi-Ershadi, Abdolghafar Hasanzehi, Mohammad R Shirzadi, Seyed H Moosa-Kazemi, Mohammad M Sedaghat
The possibility of the rapid and global spread of Zika, chikungunya, yellow fever, and dengue fever by Aedes albopictus is well documented and may be facilitated by changes in climate. To avert and manage health risks, climatic and topographic information can be used to model and forecast which areas may be most prone to the establishment of Ae. albopictus. We aimed to weigh and prioritize the predictive value of various meteorological and climatic variables on distributions of Ae. albopictus in south-eastern Iran using the Analytical Hierarchy Process...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28928416/zika-virus-infection-confers-protection-against-west-nile-virus-challenge-in-mice
#9
Ángela Vázquez-Calvo, Ana-Belén Blázquez, Estela Escribano-Romero, Teresa Merino-Ramos, Juan-Carlos Saiz, Miguel A Martín-Acebes, Nereida Jiménez de Oya
Flaviviruses are RNA viruses that constitute a worrisome threat to global human and animal health. Zika virus (ZIKV), which was initially reported to cause a mild disease, recently spread in the Americas, infecting millions of people. During this recent epidemic, ZIKV infection has been linked to serious neurological diseases and birth defects, specifically Guillain-Barrè syndrome (GBS) and microcephaly. Because information about ZIKV immunity remains scarce, we assessed the humoral response of immunocompetent mice to infection with three viral strains of diverse geographical origin (Africa, Asia and America)...
September 20, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28927743/does-a-mandibular-access-osteotomy-improve-survival-in-pt2-oral-tongue-cancers-retrospective-study-at-a-single-institution
#10
H S Ong, S Gokavarapu, Z Tian, J Li, W Cao, C P Zhang
The surgical approach to the resection of oral tongue cancers can involve transoral resection (TOR) or a temporary mandibulotomy access (TMA). There are no relevant guidelines, and the oncological safety of TOR needs consideration. The objective of this study was to investigate TMA and TOR in pT2 oral tongue cancer surgery with regard to cancer outcomes. Demographic, surgical, and histology data from primary pT2 tongue cancers were recorded and evaluated through multivariate Cox regression for local recurrence (LR), disease-free survival (DFS), and overall survival (OS)...
September 15, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28927433/modelling-the-current-distribution-and-predicted-spread-of-the-flea-species-ctenocephalides-felis-infesting-outdoor-dogs-in-spain
#11
Rosa Gálvez, Vicenzo Musella, Miguel A Descalzo, Ana Montoya, Rocío Checa, Valentina Marino, Oihane Martín, Giuseppe Cringoli, Laura Rinaldi, Guadalupe Miró
BACKGROUND: The cat flea, Ctenocephalides felis, is the most prevalent flea species detected on dogs and cats in Europe and other world regions. The status of flea infestation today is an evident public health concern because of their cosmopolitan distribution and the flea-borne diseases transmission. This study determines the spatial distribution of the cat flea C. felis infesting dogs in Spain. Using geospatial tools, models were constructed based on entomological data collected from dogs during the period 2013-2015...
September 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28927006/emerging-roles-of-heparanase-in-viral-pathogenesis
#12
REVIEW
Neel Thakkar, Tejabhiram Yadavalli, Dinesh Jaishankar, Deepak Shukla
Heparan sulfate (HS) is ubiquitously expressed on mammalian cells. It is a polysaccharide that binds growth factors, cytokines, and chemokines, and thereby controls several important physiological functions. Ironically, many human pathogens including viruses interact with it for adherence to host cells. HS functions can be regulated by selective modifications and/or selective cleavage of the sugar chains from the cell surface. In mammals, heparanase (HPSE) is the only known enzyme capable of regulating HS functions via a selective endoglycosidase activity that cleaves polymeric HS chains at internal sites...
September 18, 2017: Pathogens
https://www.readbyqxmd.com/read/28926722/innovation-in-care-for-individuals-with-cognitive-impairment-can-reimbursement-policy-spread-best-practices
#13
Soo Borson, Joshua Chodosh, Cyndy Cordell, Beth Kallmyer, Malaz Boustani, Anna Chodos, Jatin K Dave, Lisa Gwyther, Susan Reed, David B Reuben, Stephen Stabile, Monica Willis-Parker, William Thies
There is now an unprecedented opportunity to improve the care of the over 5 million people who are living with Alzheimer's disease and related dementias and many more with cognitive impairment due to brain injury, systemic diseases, and other causes. The introduction of a new Medicare care planning benefit-long sought openly by advocacy organizations and clinicians and badly needed by patients and families-could greatly improve health care quality, but only if widely and fully implemented. We describe the components of this new benefit and its promise of better clinical care, as well as its potential to create a new platform for clinical and health outcomes research...
September 16, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28926025/animal-health-and-price-transmission-along-livestock-supply-chains
#14
M Aragrande, M Canali
Animal health diseases can severely affect the food supply chain by causing variations in prices and market demand. Price transmission analysis reveals in what ways price variations are transmitted along the supply chain, and how supply chains of substitute products and different regional markets are also affected. In perfect markets, a price variation would be completely and instantaneously transmitted across the different levels of the supply chain: producers, the processing industry, retailers and consumers...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28926023/the-political-economy-of-bovine-tuberculosis-in-great-britain
#15
R M Bennett
A brief history of bovine tuberculosis (bTB) and its control in Great Britain (GB) is presented. Numerous diverse policies to control the disease in humans, cattle and wildlife have been pursued over the last 100 years and many millions of pounds have been spent. After notable success in reducing the incidence and prevalence of bTB in cattle in GB from the 1950s to the mid-1980s, the geographical spread of the disease and the number of cattle slaughtered have increased continually since that time, with a high point of bTB incidence in 2008...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28926015/an-economic-assessment-of-foot-and-mouth-disease-in-japan
#16
Y Hayama, Y Osada, D Oushiki, T Tsutsui
A large-scale foot and mouth disease (FMD) epidemic in Japan in 2010 caused severe economic losses for livestock and related industries. In this paper, the authors develop a clear and usable framework to estimate the economic impact of this FMD outbreak. An economic analysis is then conducted by combining this framework with an epidemiological model. The framework estimates the direct and indirect costs to livestock and related industries by applying an input-output model, as well as by addressing expenditure on disease control...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28926013/insights-for-the-assessment-of-the-economic-impact-of-endemic-diseases-specific-adaptation-of-economic-frameworks-using-the-case-of-bovine-viral-diarrhoea
#17
A W Stott, G J Gunn
Generic frameworks for the economic analysis of farm animal disease are now well established. The paper, therefore, uses bovine viral diarrhoea (BVD) as an example to explore how these frameworks need to be adapted to fit the characteristics of a particular disease and the specific objectives of the analysis. In the case of BVD, given the relative strength of tests available to correctly identify virus-positive animals, thus enabling them to be culled, the emphasis has been on cost-benefit analysis of regional and national certification/eradication schemes...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28925970/current-status-of-rift-valley-fever-vaccine-development
#18
REVIEW
Bonto Faburay, Angelle Desiree LaBeaud, D Scott McVey, William C Wilson, Juergen A Richt
Rift Valley Fever (RVF) is a mosquito-borne zoonotic disease that presents a substantial threat to human and public health. It is caused by Rift Valley fever phlebovirus (RVFV), which belongs to the genus Phlebovirus and the family Phenuiviridae within the order Bunyavirales. The wide distribution of competent vectors in non-endemic areas coupled with global climate change poses a significant threat of the transboundary spread of RVFV. In the last decade, an improved understanding of the molecular biology of RVFV has facilitated significant progress in the development of novel vaccines, including DIVA (differentiating infected from vaccinated animals) vaccines...
September 19, 2017: Vaccines
https://www.readbyqxmd.com/read/28925885/spreading-depolarization-waves-in-neurological-diseases-a-short-review-about-its-pathophysiology-and-clinical-relevance
#19
Yağmur Çetin Taş, İhsan Solaroğlu, Yasemin Gürsoy-Özdemir
Lesion growth following acutely injured brain tissue after stroke, subarachnoid hemorrhage and traumatic brain injury is an important issue and a new target area for promising therapeutic interventions. Spreading depolarization or peri-lesion depolarization waves were demonstrated as one of the significant contributors of continued lesion growth. In this short review, we discuss the pathophysiology for SD forming events and try to list findings detected in neurological disorders like migraine, stroke, subarachnoid hemorrhage and traumatic brain injury in both human as well as experimental studies...
September 15, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28925418/mhealth-application-areas-and-technology-combinations-a-comparison-of-literature-from-high-and-low-middle-income-countries
#20
Haitham Abaza, Michael Marschollek
BACKGROUND: With the continuous and enormous spread of mobile technologies, mHealth has evolved as a new subfield of eHealth. While eHealth is broadly focused on information and communication technologies, mHealth seeks to explore more into mobile devices and wireless communication. Since mobile phone penetration has exceeded other infrastructure in low and middle-income countries (LMICs), mHealth is seen as a promising component to provide pervasive and patient-centered care. OBJECTIVES: The aim of our research work for this paper is to examine the mHealth literature to identify application areas, target diseases, and mHealth service and technology types that are most appropriate for LMICs...
August 8, 2017: Methods of Information in Medicine
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