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https://www.readbyqxmd.com/read/29786527/retrospective-analysis-of-bluetongue-farm-risk-profile-definition-based-on-biology-farm-management-practices-and-climatic-data
#1
Stefano Cappai, Federica Loi, Annamaria Coccollone, Marino Contu, Paolo Capece, Michele Fiori, Simona Canu, Cipriano Foxi, Sandro Rolesu
Bluetongue (BT) is a vector-borne disease transmitted by species of Culicoides midges (Diptera: Ceratopogonidae). Many studies have contributed to clarifying various aspects of its aetiology, epidemiology and vector dynamic; however, BT remains a disease of epidemiological and economic importance that affects ruminants worldwide. Since 2000, the Sardinia region has been the most affected area of the Mediterranean basin. The region is characterised by wide pastoral areas for sheep and represents the most likely candidate region for the study of Bluetongue virus (BTV) distribution and prevalence in Italy...
July 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29786132/the-economic-case-for-a-pandemic-fund
#2
Kevin Berry, Toph Allen, Richard D Horan, Jason F Shogren, David Finnoff, Peter Daszak
The rapid urban spread of Ebola virus in West Africa in 2014 and consequent breakdown of control measures led to a significant economic impact as well as the burden on public health and wellbeing. The US government appropriated $5.4 Billion for FY2015 and WHO proposed a $100 Million emergency fund largely to curtail the threat of future outbreaks. Using epidemiological analyses and economic modeling, we propose that the best use of these and similar funds would be to serve as global insurance against the continued threat of emerging infectious diseases...
May 21, 2018: EcoHealth
https://www.readbyqxmd.com/read/29785893/evaluating-vaccination-strategies-to-control-foot-and-mouth-disease-a-country-comparison-study
#3
T G Rawdon, M G Garner, R L Sanson, M A Stevenson, C Cook, C Birch, S E Roche, K A Patyk, K N Forde-Folle, C Dubé, T Smylie, Z D Yu
Vaccination is increasingly being recognised as a potential tool to supplement 'stamping out' for controlling foot-and-mouth disease (FMD) outbreaks in non-endemic countries. Infectious disease simulation models provide the opportunity to determine how vaccination might be used in the face of an FMD outbreak. Previously, consistent relative benefits of specific vaccination strategies across different FMD simulation modelling platforms have been demonstrated, using a UK FMD outbreak scenario. We extended this work to assess the relative effectiveness of selected vaccination strategies in five countries: Australia, New Zealand, the USA, the UK and Canada...
May 22, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29785657/novel-non-invasive-early-detection-of-lung-cancer-using-liquid-immunobiopsy-metabolic-activity-profiles
#4
Yochai Adir, Shoval Tirman, Shirley Abramovitch, Cynthia Botbol, Aviv Lutaty, Tali Scheinmann, Eyal Davidovits, Irit Arbel, Giora Davidovits, Sonia Schneer, Michal Shteinberg, Hagit Peretz Soroka, Ruven Tirosh, Fernando Patolsky
Lung cancer is the leading cause of cancer death worldwide. Survival is largely dependent on the stage of diagnosis: the localized disease has a 5-year survival greater than 55%, whereas, for spread tumors, this rate is only 4%. Therefore, the early detection of lung cancer is key for improving prognosis. In this study, we present an innovative, non-invasive, cancer detection approach based on measurements of the metabolic activity profiles of immune system cells. For each Liquid ImmunoBiopsy test, a 384 multi-well plate is loaded with freshly separated PBMCs, and each well contains 1 of the 16 selected stimulants in several increasing concentrations...
May 21, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29785214/etiological-trends-and-patterns-of-antimicrobial-resistance-in-respiratory-infections
#5
Salma M Al-Zain Ahmed, Sara S Abdelrahman, Doua M Saad, Isra S Osman, Modasir G Osman, Eltahir A G Khalil
Background: Respiratory infections are one of the commonest causes of morbidity and mortality related to infectious diseases worldwide. The emergence of antimicrobial resistance is a major global health problem which is well established in developing countries. Good clinical suspicion and correct laboratory identification of respiratory infection causing organisms followed by the appropriate management are needed to compact both community-acquired and nosocomial infection respiratory infections...
2018: Open Microbiology Journal
https://www.readbyqxmd.com/read/29785029/highly-bactericidal-macroporous-antimicrobial-polymeric-gel-for-point-of-use-water-disinfection
#6
Amit Kumar, Cyrille Boyer, Leena Nebhani, Edgar H H Wong
Access to clean and safe water supply remains inadequate in many developing countries. One of the key challenges is to remove pathogenic bacteria from the water supply via effective water disinfection technologies to prevent the spread of diseases and to ensure the safety of consumers. Herein, a highly effective point-of-use (on-demand) water disinfection technology, in the form of a polymeric scaffold called macroporous antimicrobial polymeric gel (MAPG), is demonstrated. MAPG is easy to fabricate, completely organic and possess inherent antimicrobial property which makes it non-reliant on inorganic compounds such as silver where the long-term toxicity remains unknown...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29783691/old-and-young-actors-playing-novel-roles-in-the-drama-of-multiple-myeloma-bone-marrow-microenvironment-dependent-drug-resistance
#7
REVIEW
Sabrina Manni, Marilena Carrino, Gianpietro Semenzato, Francesco Piazza
Multiple myeloma (MM) is the second most frequent hematologic cancer. In addition to the deleterious effects of neoplastic plasma cell growth and spreading during the disease evolution, this tumor is characterized by the serious pathological consequences due to the massive secretion of monoclonal immunoglobulins and by the derangement of bone physiology with progressive weakening of the skeleton. Despite significant progresses having been made in the last two decades in the therapeutic management of this plasma cell tumor, MM remains invariably lethal, due to its extremely complex genetic architecture and to the constant protection it receives from the tumor niche, which is represented by the bone marrow microenvironment...
May 18, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29783251/prevalence-of-risk-factors-of-allergic-diseases-among-children-aged-8-9-years-in-poltava-region-the-results-of-the-first-stage-of-the-research
#8
Tetyana O Kryuchko, Iryna A Holovanova, Olha Y Tkachenko, Mariya O Melnyk, Kateryna V Pocheniuk
OBJECTIVE: Introduction: According to the European Academy of Allergology and Clinical Immunology (EAACI, 2016), allergy is the most common chronic disease in Europe. The aim: The aim of the investigation is to study the spread of risk factors of allergic reactions in children who are 8-9 years old of Poltava region. PATIENTS AND METHODS: Materials and methods: The investigation included two stages: the 1st contained interviewing; the 2nd one - additional clinical and lab investigation of children, who require the further diagnosis specification...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783223/-rational-nutrition-as-a-prerequisite-for-eliminating-the-risk-of-overweight-public-opinion-and-practice
#9
Natalia O Ryngach, Marina B Scherbinina, Tatiana M Shevchenko, Victoria M Gladun, Volodymyr I Sarychev
OBJECTIVE: Introduction: The awareness of the working-age population regarding the principles of a healthy lifestyle and risk factors of diseases is analyzed. Aim: To identify and characterize the level of awareness of the working-age population regarding the essence of a healthy lifestyle and risk factors (with a focus on irrational nutrition and its consequences). PATIENTS AND METHODS: Materials and methods: In the sociological study (2017), on request of Dnipropetrovsk regional state administration, methods of deep (N20) and personalized formal interviews (N2000) were used according to a specially developed methodology of qualitative and quantitative research stages and data collection tools...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29782835/multi-pronged-interactions-underlie-inhibition-of-%C3%AE-synuclein-aggregation-by-%C3%AE-synuclein
#10
Jonathan K Williams, Xue Yang, Tamr B Atieh, Michael P Olson, Sagar D Khare, Jean Baum
The intrinsically disordered protein β-synuclein is known to inhibit the aggregation of its intrinsically disordered homolog, α-synuclein, which is implicated in Parkinson's disease. While β-synuclein itself does not form fibrils at the cytoplasmic pH7.4, alteration of pH and other environmental perturbations are known to induce its fibrilization. However, the sequence and structural determinants of β-synuclein inhibition and self-aggregation are not well understood. We have utilized a series of domain-swapped chimeras of α-synuclein and β-synuclein to probe the relative contributions of the N-terminal, C-terminal and the central Non-Amyloid-β Component (NAC) domains to the inhibition of α-synuclein aggregation...
May 18, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29782471/new-approach-in-acne-therapy-a-specific-bacteriocin-activity-and-a-targeted-anti-il-8-property-in-just-1-probiotic-strain-the-l-salivarius-ls03
#11
Francesca Deidda, Angela Amoruso, Stefania Nicola, Teresa Graziano, Marco Pane, Luca Mogna
GOALS: The aim of this research was to assess the antibacterial activity of Lactobacillus salivarius LS03 (DSM 22776) against Propionibacterium acnes and its anti-inflammatory properties by inhibiting P. acnes-induced interleukin-8 (IL-8) release. BACKGROUND: Acne is the most common skin disease, causing significant psychosocial problems for those afflicted. Currently available agents for acne treatment, such as oral antibiotics, have limited use. Thus, development of novel agents to treat this disease is needed...
May 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29782309/in-memoriam-assistant-professor-kre%C3%A5-imir-kostovi%C3%A4-md-phd-16-october-1969-15-october-2017
#12
Branka Marinović
On a Sunday afternoon almost six months ago, we were deeply moved by the news that our Krešimir is no longer with us. The sad news spread from Sarajevo with the speed only most horrible and saddest news can achieve. And everybody who was reached by these news wondered whether it was possible and whether it was true. Because our professor Kostović left us a day before his 48th birthday. Krešimir Kostović was born on the 16th October 1969 in Zagreb, where he completed primary and secondary education. He enrolled at the University of Zagreb School of Medicine in 1988, and got his medical degree in 1995...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29782305/tatami-mats-a-source-of-pitted-keratolysis-in-a-martial-arts-athlete
#13
Anamaria Balić, Zrinka Bukvić Mokos, Branka Marinović, Daniela Ledić Drvar
Dear Editor, Pitted keratolysis (PK), also known as keratosis plantaris sulcatum, is a non-inflammatory, bacterial, superficial cutaneous infection, characterized by many discrete superficial crateriform ''pits'' and erosions in the thickly keratinized skin of the weight-bearing regions of the soles of the feet (1). The disease often goes unnoticed by the patient, but when it is noticed it is because of the unbearable malodor and hyperhidrosis of the feet, which are socially unacceptable and cause great anxiety to many of the patients...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29781974/prognostic-value-of-shape-descriptive-factors-for-the-progression-of-geographic-atrophy-secondary-to-age-related-macular-degeneration
#14
Maximilian Pfau, Moritz Lindner, Lukas Goerdt, Sarah Thiele, Jennifer Nadal, Matthias Schmid, Steffen Schmitz-Valckenberg, SriniVas R Sadda, Frank G Holz, Monika Fleckenstein
PURPOSE: To systematically compare the prognostic value of multiple shape-descriptive factors in the natural course of the disease. METHODS: A total of 296 eyes of 201 patients (female patients 130; mean age: 72.2 ± 13.08 years) with a median follow-up of 2.38 years from 2 prospective, noninterventional natural history studies (Fundus-Autofluorescence-in-Age-related-Macular-Degeneration [clinicaltrials.gov identifier NCT00393692], Directional-Spread-in-Geographic-Atrophy [NCT02051998]) were included in the analysis...
May 16, 2018: Retina
https://www.readbyqxmd.com/read/29781594/-monoclonal-spread-of-multi-drug-resistant-ctx-m-15-producing-klebsiella-pneumoniae-impact-of-measures-to-control-the-outbreak
#15
M A Asencio Egea, M Huertas Vaquero, C Muñoz-Cuevas, J Gaitán Pitera, O Herráez Carrera, P Alcázar Carmona, H D Patiño Ortega, M Franco Huerta, C Román Ortiz, M C Conde García, R Carranza González, J R Barberá, V Bautista Sánchez
OBJECTIVE: To describe an outbreak of multi-drug resistant extended-spectrum β-lactamases-producing Klebsiella pneumoniae (MDR-ESBL-KPN) and the impact of measures for its control. METHODS: We reviewed the patients´ clinical records with MDR-ESBL-KPN isolation during 2013-2016 with resistance to fluoroquinolones, aminoglycosides, fosfomycin, and nitrofurantoin; susceptible to imipenem, meropenem, colistin, and tigecycline and variable to ertapenem and cotrimoxazole (Vitek-2)...
May 18, 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29781412/imported-cases-and-minimum-temperature-drive-dengue-transmission-in-guangzhou-china-evidence-from-arimax-model
#16
Q L Jing, Q Cheng, J M Marshall, W B Hu, Z C Yang, J H Lu
Dengue is the fastest spreading mosquito-transmitted disease in the world. In China, Guangzhou City is believed to be the most important epicenter of dengue outbreaks although the transmission patterns are still poorly understood. We developed an autoregressive integrated moving average model incorporating external regressors to examine the association between the monthly number of locally acquired dengue infections and imported cases, mosquito densities, temperature and precipitation in Guangzhou. In multivariate analysis, imported cases and minimum temperature (both at lag 0) were both associated with the number of locally acquired infections (P < 0...
May 21, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29781209/oral-phase-dysphagia-in-facial-onset-sensory-and-motor-neuronopathy
#17
Mitsuru Watanabe, Wataru Shiraishi, Ryo Yamasaki, Noriko Isobe, Motohiro Sawatsubashi, Ryuji Yasumatsu, Takashi Nakagawa, Jun-Ichi Kira
INTRODUCTION: Facial onset motor and sensory neuronopathy (FOSMN) is a rare disease whose cardinal features are initial asymmetrical facial sensory deficits followed by bulbar symptoms and spreading of sensory and motor deficits from face to scalp, neck, upper trunk, and upper extremities in a rostral-caudal direction. Although bulbar involvement is frequently observed in FOSMN, dysphagia in these patients has not been fully described. In this study, we aimed to characterize dysphagia as a prognostic factor in FOSMN by investigating our institutional case series...
May 21, 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29780850/canada-wide-epidemic-of-emm74-group-a-streptococcus-invasive-disease
#18
Sarah Teatero, Allison McGeer, Gregory J Tyrrell, Linda Hoang, Hanan Smadi, Marc-Christian Domingo, Paul N Levett, Michael Finkelstein, Ken Dewar, Agron Plevneshi, Taryn B T Athey, Jonathan B Gubbay, Michael R Mulvey, Irene Martin, Walter Demczuk, Nahuel Fittipaldi
Background: The number of invasive group A Streptococcus (iGAS) infections due to hitherto extremely rare type emm74 strains has increased in several Canadian provinces since late 2015. We hypothesized that the cases recorded in the different provinces are linked and caused by strains of an emm74 clone that recently emerged and expanded explosively. Methods: We analyzed both active and passive surveillance data for iGAS infections and used whole-genome sequencing to investigate the phylogenetic relationships of the emm74 strains responsible for these invasive infections country-wide...
May 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29780811/does-size-matter-to-models-exploring-the-effect-of-herd-size-on-outputs-of-a-herd-level-disease-spread-simulator
#19
Mary Van Andel, Tracey Hollings, Richard Bradhurst, Andrew Robinson, Mark Burgman, M Carolyn Gates, Paul Bingham, Tim Carpenter
Disease spread modeling is widely used by veterinary authorities to predict the impact of emergency animal disease outbreaks in livestock and to evaluate the cost-effectiveness of different management interventions. Such models require knowledge of basic disease epidemiology as well as information about the population of animals at risk. Essential demographic information includes the production system, animal numbers, and their spatial locations yet many countries with significant livestock industries do not have publically available and accurate animal population information at the farm level that can be used in these models...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29780771/proposal-for-cervical-cancer-screening-in-the-era-of-hpv-vaccination
#20
REVIEW
Yung-Taek Ouh, Jae Kwan Lee
Eradication of cervical cancer involves the expansion of human papillomavirus (HPV) vaccine coverage and the development of efficient screening guidelines that take vaccination into account. In Korea, the HPV National Immunization Program was launched in 2016 and is expected to shift the prevalence of HPV genotypes in the country, among other effects. The experiences of another countries that implement national immunization programs should be applied to Korea. If HPV vaccines spread nationwide with broader coverage, after a few decades, cervical intraepithelial lesions or invasive cancer should become a rare disease, leading to a predictable decrease in the positive predictive value of cervical screening cytology...
May 2018: Obstetrics & Gynecology Science
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