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Disorganization retinal inner layers

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https://www.readbyqxmd.com/read/29615095/loss-of-xbp1-accelerates-age-related-decline-in-retinal-function-and-neurodegeneration
#1
Todd McLaughlin, Marek Falkowski, Jae Whan Park, Stephen Keegan, Michael Elliott, Joshua J Wang, Sarah X Zhang
BACKGROUND: Aging is the strongest risk factor for neurodegenerative diseases and extended age results in neuronal degeneration and functional decline in the visual system. Among many contributing factors to age-related deterioration of neurons is an insufficient activation of the Unfolded Protein Response (UPR) in the endoplasmic reticulum (ER) in response to cellular stress. X-box binding protein 1 (XBP1) is a major component of the UPR and is essential for maintaining protein homeostasis and reducing cellular stresses...
April 4, 2018: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/29526379/an-immunohistochemical-and-ultrastructural-analysis-of-the-retina-in-tadalafil-cialis-treated-rats
#2
Nahla Reda Sarhan, Nesreen Moustafa Omar
Tadalafil (Cialis) is one of the most commonly used phosphodiesterase type5 (PDE5) inhibitors. This work aimed to analyze the histological and ultrastructural changes provoked by chronic tadalafil administration in the rat retina, correlate between such changes and PDE5 immunoexpression and to evaluate the possible reversibility of these changes. Thirty Sprague Dawley male rats were randomly distributed into 3 groups. Control group; given 1 ml distilled water daily for 6 weeks. Tadalafil group; given tadalafil in a daily dose of 2...
March 8, 2018: Acta Histochemica
https://www.readbyqxmd.com/read/29506510/predictive-multi-imaging-biomarkers-relevant-for-visual-acuity-in-idiopathic-macular-telangiectasis-type-1
#3
Jingli Guo, WenYi Tang, Xiaofeng Ye, Haixiang Wu, Gezhi Xu, Wei Liu, Yongjin Zhang
BACKGROUND: To evaluate the structural changes associated with visual acuity (VA) in patients with idiopathic macular telangiectasia (MT) type 1 using multimodal imaging modalities. METHODS: A retrospective study of 14 patients with MT type 1 and of 10 eyes from 10 healthy individuals as age-matched controls was conducted. The medical records of patients who had undergone colour fundus photography, spectral domain optical coherence tomography (OCT), fluorescein angiography and OCT angiography were reviewed...
March 5, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29376234/multimodal-imaging-in-diabetic-macular-edema
#4
REVIEW
Dhariana Acón, Lihteh Wu
Throughout ophthalmic history it has been shown that progress has gone hand in hand with technological breakthroughs. In the past, fluorescein angiography and fundus photographs were the most commonly used imaging modalities in the management of diabetic macular edema (DME). Today, despite the moderate correlation between macular thickness and functional outcomes, spectral domain optical coherence tomography (SD-OCT) has become the DME workhorse in clinical practice. Several SD-OCT biomarkers have been looked at including presence of epiretinal membrane, vitreomacular adhesion, disorganization of the inner retinal layers, central macular thickness, integrity of the ellipsoid layer, and subretinal fluid, among others...
January 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29327033/disorganization-of-inner-retina-and-outer-retinal-morphology-in-diabetic-macular-edema
#5
Radha Das, Gareth Spence, Ruth E Hogg, Michael Stevenson, Usha Chakravarthy
Importance: In diabetic macular edema (DME), identification of baseline markers on spectral-domain optical coherence tomography (SD-OCT) and their association with severity of diabetic retinopathy (DR) might aid in disease management and the design of future trials. Objective: To examine associations between DR severity, retinal morphology on SD-OCT, and visual acuity in participants with DME. Design, Setting, and Participants: This cross-sectional observational case series was conducted at a single tertiary care referral center...
February 1, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29228252/retinal-reflectivity-measurement-for-cone-impairment-estimation-and-visual-assessment-after-diabetic-macular-edema-resolution-recover-dme
#6
Benjamin Guyon, Emeric Elphege, Mathieu Flores, Anne-Sophie Gauthier, Bernard Delbosc, Maher Saleh
Purpose: Photoreceptor loss has been suspected of being involved in incomplete visual recovery after diabetic macular edema (DME) resolution. Recent studies have shown that cone density in the perifoveal area could be estimated by in vivo measurements of the outer retinal reflectivity on optical coherence tomography (OCT). The main objective of this study was to assess the photoreceptor layer reflectivity after DME resolution and to determine its relationship with final visual acuity (VA)...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29077605/measurements-of-retinal-fluid-by-oct-leakage-in-diabetic-macular-edema-a-biomarker-of-visual-acuity-response-to-treatment
#7
Ana Rita Santos, Dalila Alves, Torcato Santos, João Figueira, Rufino Silva, José G Cunha-Vaz
PURPOSE: To evaluate the effects of anti-vascular endothelial growth factor treatment on retinal fluid in patients with diabetic macular edema by using optical coherence tomography leakage (OCT-L), a new method of quantifying sites of lower than normal optical reflectivity (LOR) in OCT, and to correlate these findings with best-corrected visual acuity (BCVA) response. METHODS: Prospective analysis of 21 eyes with diabetic macular edema, naive to anti-vascular endothelial growth factor treatment...
October 26, 2017: Retina
https://www.readbyqxmd.com/read/29068912/optical-coherence-tomography-angiography-to-detect-macular-capillary-ischemia-in-patients-with-inner-retinal-changes-after-resolved-diabetic-macular-edema
#8
Hamid-Reza Moein, Eduardo A Novais, Carl B Rebhun, Emily D Cole, Ricardo N Louzada, André J Witkin, Caroline R Baumal, Jay S Duker, Nadia K Waheed
PURPOSE: To compare foveal vascular anatomy between patients with and without disorganization of retinal inner layers (DRILs) after resolved diabetic macular edema using optical coherence tomography angiography (OCTA). METHODS: Twenty-four eyes of 21 age- and sex-matched patients with resolved diabetic macular edema were included in this retrospective, cross-sectional study. All eyes were imaged with enhanced high-definition line or cross-line structural B scans and 3 × 3-mm OCTA scans...
October 24, 2017: Retina
https://www.readbyqxmd.com/read/28880978/quantitative-assessment-of-microstructural-changes-of-the-retina-in-infants-with-congenital-zika-syndrome
#9
COMPARATIVE STUDY
Tomas S Aleman, Camila V Ventura, Milena M Cavalcanti, Leona W Serrano, Anastasia Traband, Akosua A Nti, Adriana L Gois, Vasco Bravo-Filho, Thayze T Martins, Charles W Nichols, Mauricio Maia, Rubens Belfort
Importance: A better pathophysiologic understanding of the neurodevelopmental abnormalities observed in neonates exposed in utero to Zika virus (ZIKV) is needed to develop treatments. The retina as an extension of the diencephalon accessible to in vivo microcopy with spectral-domain optical coherence tomography (SD-OCT) can provide an insight into the pathophysiology of congenital Zika syndrome (CZS). Objective: To quantify the microstructural changes of the retina in CZS and compare these changes with those of cobalamin C (cblC) deficiency, a disease with potential retinal maldevelopment...
October 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28837790/disorganization-of-the-retinal-inner-layers-as-a-predictor-of-visual-acuity-in-eyes-with-macular-edema-secondary-to-vein-occlusion
#10
MULTICENTER STUDY
Michael Mimouni, Or Segev, Dalia Dori, Noa Geffen, Victor Flores, Ori Segal
PURPOSE: To determine whether spectral-domain optical coherence tomography (SD-OCT) disorganization of the retinal inner layers (DRIL) is predictive of best-corrected visual acuity (BCVA) in retinal vein occlusion macular edema (RVO-ME). DESIGN: Retrospective cohort study. METHODS: Setting: Two tertiary centers. PATIENTS: Treatment-naïve RVO-ME receiving monthly intravitreal bevacizumab. OBSERVATION PROCEDURES: Spectral-domain optical coherence tomography (SD-OCT) images from baseline, 4-month, and 8-month visits...
October 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28767550/impact-of-long-term-intravitreal-anti-vascular-endothelial-growth-factor-on-preexisting-microstructural-alterations-in-diabetic-macular-edema
#11
Magdalena A Wirth, Juliana Wons, Florentina J Freiberg, Matthias D Becker, Stephan Michels
PURPOSE: Evaluation of the influence of long-term intravitreal anti-vascular endothelial growth factor treatment on preexisting retinal microstructural alterations in patients with diabetic macular edema. METHODS: Eyes with diabetic macular edema and a history of ≥ 20 intravitreal anti-vascular endothelial growth factor (aflibercept and/or ranibizumab) injections were included in this retrospective study. Primary outcome was the extent of disorganization of retinal inner layers, alterations at the outer plexiform layer/Henle fiber layer junction, disruption of external limiting membrane/ellipsoid zone, disruption of retinal pigment epithelium/Bruch complex, and retinal atrophy at baseline versus after ≥ 20 intravitreal injections as visualized by spectral-domain optical coherence tomography images...
August 1, 2017: Retina
https://www.readbyqxmd.com/read/28613220/optical-coherence-tomography-baseline-predictors-for-initial-best-corrected-visual-acuity-response-to-intravitreal-anti-vascular-endothelial-growth-factor-treatment-in-eyes-with-diabetic-macular-edema-the-chartres-study
#12
Ana R Santos, Miguel  Costa, Christian Schwartz, Dalila Alves, João Figueira, Rufino Silva, Jose G Cunha-Vaz
PURPOSE: To identify baseline optical coherence tomography morphologic characteristics predicting the visual response to anti-vascular endothelial growth factor therapy in diabetic macular edema. METHODS: Sixty-seven patients with diabetic macular edema completed a prospective, observational study (NCT01947881-CHARTRES). All patients received monthly intravitreal injections of Lucentis for 3 months followed by PRN treatment and underwent best-corrected visual acuity measurements and spectral domain optical coherence tomography at Baseline, Months 1, 2, 3, and 6...
May 2, 2017: Retina
https://www.readbyqxmd.com/read/28419393/role-of-disorganization-of-retinal-inner-layers-as-an-optical-coherence-tomography-biomarker-in-diabetic-and-uveitic-macular-edema
#13
Dilraj S Grewal, Seenu M Hariprasad, Glenn J Jaffe
No abstract text is available yet for this article.
April 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28406860/predictive-value-of-optical-coherence-tomographic-features-in-the-bevacizumab-and-ranibizumab-in-patients-with-diabetic-macular-edema-brdme-study
#14
Ward Fickweiler, Ann-Sofie M E Schauwvlieghe, Reinier O Schlingemann, Johanna M Maria Hooymans, Leonoor I Los, Frank D Verbraak
PURPOSE: To establish the predictive value of specific optical coherence tomography retinal features on visual outcomes and retinal thickness during anti-vascular endothelial growth factor treatment in patients with diabetic macular edema. METHODS: Post hoc analysis of compound data of a prospective, 6-month, multicenter, randomized controlled trial of 119 patients with diabetic macular edema receiving either intravitreal bevacizumab or ranibizumab were analyzed to assess the associations between baseline retinal morphologic parameters and change in best-corrected visual acuity and central subfield thickness...
April 11, 2017: Retina
https://www.readbyqxmd.com/read/28253400/long-term-characterization-of-retinal-degeneration-in-royal-college-of-surgeons-rats-using-spectral-domain-optical-coherence-tomography
#15
Renee C Ryals, Michael D Andrews, Shreya Datta, Aaron S Coyner, Cody M Fischer, Yuquan Wen, Mark E Pennesi, Trevor J McGill
Purpose: Prospective treatments for age-related macular degeneration and inherited retinal degenerations are commonly evaluated in the Royal College of Surgeons (RCS) rat before translation into clinical application. Historically, retinal thickness obtained through postmortem anatomic assessments has been a key outcome measure; however, utility of this measurement is limited because it precludes the ability to perform longitudinal studies. To overcome this limitation, the present study was designed to provide a baseline longitudinal quantification of retinal thickness in the RCS rat by using spectral-domain optical coherence tomography (SD-OCT)...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28237411/association-of-disorganization-of-retinal-inner-layers-with-visual-acuity-in-eyes-with-uveitic-cystoid-macular-edema
#16
RANDOMIZED CONTROLLED TRIAL
Dilraj S Grewal, Matthew L O'Sullivan, Martina Kron, Glenn J Jaffe
PURPOSE: To determine whether disorganization of retinal inner layers (DRIL) assessed by spectral-domain optical coherence tomography (SDOCT) correlates with visual acuity (VA) in eyes with uveitic cystoid macular edema (CME). DESIGN: Secondary analysis of randomized clinical trial data. METHODS: Fifty-six eyes of 42 patients with uveitic CME were prospectively imaged as part of the VISUAL-1 trial (Clinicaltrials.gov identifier NCT01138657)...
May 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28195614/omega-sign-a-distinct-optical-coherence-tomography-finding-in-macular-combined-hamartoma-of-retina-and-retinal-pigment-epithelium
#17
Vinod Kumar, Rohan Chawla, Koushik Tripathy
BACKGROUND AND OBJECTIVE: To report a distinct optical coherence tomography (OCT) appearance of macular combined hamartoma of retina and retinal pigment epithelium (CHRRPE). PATIENTS AND METHODS: This is a retrospective case series of four eyes of four patients with macular CHRRPE who were assessed with the help of color fundus photographs, swept-source OCT (SS-OCT), and fundus fluorescein angiography wherever required. RESULTS: All four patients presented with decreased visual acuity...
February 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/27986385/natural-history-of-the-central-structural-abnormalities-in-choroideremia-a-prospective-cross-sectional-study
#18
Tomas S Aleman, Grace Han, Leona W Serrano, Nicole M Fuerst, Emily S Charlson, Denise J Pearson, Daniel C Chung, Anastasia Traband, Wei Pan, Gui-Shuang Ying, Jean Bennett, Albert M Maguire, Jessica I W Morgan
PURPOSE: To describe in detail the central retinal structure of a large group of patients with choroideremia (CHM). DESIGN: A prospective, cross-sectional, descriptive study. PARTICIPANTS: Patients (n = 97, age 6-71 years) with CHM and subjects with normal vision (n = 44; ages 10-50 years) were included. METHODS: Subjects were examined with spectral-domain optical coherence tomography (SD OCT) and near-infrared reflectance imaging...
March 2017: Ophthalmology
https://www.readbyqxmd.com/read/27966487/expressions-of-visual-pigments-and-synaptic-proteins-in-neonatal-chick-retina-exposed-to-light-of-variable-photoperiods
#19
Kumar Abhiram Jha, Tapas C Nag, Shashi Wadhwa, Tara Sankar Roy
Light causes damage to the retina, which is one of the supposed factors for age-related macular degeneration in human. Some animal species show drastic retinal changes when exposed to intense light (e.g. albino rats). Although birds have a pigmented retina, few reports indicated its susceptibility to light damage. To know how light influences a cone-dominated retina (as is the case with human), we examined the effects of moderate light intensity on the retina of white Leghorn chicks (Gallus g. domesticus). The newly hatched chicks were initially acclimatized at 500 lux for 7 days in 12 h light: 12 h dark cycles (12L:12D)...
December 2016: Journal of Biosciences
https://www.readbyqxmd.com/read/27523615/visual-acuity-is-correlated-with-the-area-of-the-foveal-avascular-zone-in-diabetic-retinopathy-and-retinal-vein-occlusion
#20
Chandrakumar Balaratnasingam, Maiko Inoue, Seungjun Ahn, Jesse McCann, Elona Dhrami-Gavazi, Lawrence A Yannuzzi, K Bailey Freund
PURPOSE: To determine if the area of the foveal avascular zone (FAZ) is correlated with visual acuity (VA) in diabetic retinopathy (DR) and retinal vein occlusion (RVO). DESIGN: Cross-sectional study. PARTICIPANTS: Ninety-five eyes of 66 subjects with DR (65 eyes), branch retinal vein occlusion (19 eyes), and central retinal vein occlusion (11 eyes). METHODS: Structural optical coherence tomography (OCT; Spectralis, Heidelberg Engineering) and OCT angiography (OCTA; Avanti, Optovue RTVue XR) data from a single visit were analyzed...
November 2016: Ophthalmology
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