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Disorganization retinal inner layers

Chandrakumar Balaratnasingam, Maiko Inoue, Seungjun Ahn, Jesse McCann, Elona Dhrami-Gavazi, Lawrence A Yannuzzi, K Bailey Freund
PURPOSE: To determine if the area of the foveal avascular zone (FAZ) is correlated with visual acuity (VA) in diabetic retinopathy (DR) and retinal vein occlusion (RVO). DESIGN: Cross-sectional study. PARTICIPANTS: Ninety-five eyes of 66 subjects with DR (65 eyes), branch retinal vein occlusion (19 eyes), and central retinal vein occlusion (11 eyes). METHODS: Structural optical coherence tomography (OCT; Spectralis, Heidelberg Engineering) and OCT angiography (OCTA; Avanti, Optovue RTVue XR) data from a single visit were analyzed...
August 11, 2016: Ophthalmology
Raphaelle Despréaux, Sarah Mrejen, Gabriel Quentel, Salomon Y Cohen
PURPOSE: To report spectral-domain optical coherence tomography, en face optical coherence tomography (OCT), and optical coherence tomography angiography findings in retinal astrocytic hamartomas. METHODS: Four cases of retinal astrocytic hamartomas, with small white or yellowish typical retinal mass, were imaged with fundus photography, intravenous fluorescein angiography, fundus autofluorescence, spectral-domain OCT, en face OCT, and OCT angiography. RESULTS: The tumor was solitary in all cases and involved the posterior pole...
August 9, 2016: Retinal Cases & Brief Reports
Sarah Perez-Roustit, Virginie Marquette, Béatrice Bocquet, Josseline Kaplan, Isabelle Perrault, Isabelle Meunier, Christian P Hamel
PURPOSE: To describe a patient with mutations in KCNJ13 presenting particular clinical features. METHODS: Standard ophthalmic examination, fundus autofluorescence, spectral domain optical coherence tomography, full-field electroretinography. The 3 exons of KCNJ13 were polymerase chain reaction amplified and Sanger sequenced. PATIENTS: A 31-year-old man with Leber congenital amaurosis. RESULTS: Patient had nystagmus since childhood, best-corrected visual acuity limited to 20/400 OD and 20/200 OS, and had cataracts extracted in both eyes...
May 19, 2016: Retinal Cases & Brief Reports
Aaron B Simmons, Morgan M Merrill, Justin C Reed, Michael R Deans, Malia M Edwards, Peter G Fuerst
PURPOSE: Abnormal retinal angiogenesis leads to visual impairment and blindness. Understanding how retinal vessels develop normally has dramatically improved treatments for people with retinal vasculopathies, but additional information about development is required. Abnormal neuron patterning in the outer retina has been shown to result in abnormal vessel development and blindness, for example, in people and mouse models with Crumbs homologue 1 (CRB1) mutations. In this study, we report and characterize a mouse model of inner retinal lamination disruption and bleeding, the Down syndrome cell adhesion molecule (Dscam) mutant, and test how neuron-neurite placement within the inner retina guides development of intraretinal vessels...
April 2016: Investigative Ophthalmology & Visual Science
Amelia R Bachleda, Larysa H Pevny, Ellen R Weiss
PURPOSE: Müller glia (MG), the principal glial cells of the vertebrate retina, display quiescent progenitor cell characteristics. They express key progenitor markers, including the high mobility group box transcription factor SOX2 and maintain a progenitor-like morphology. In the embryonic and mature central nervous system, SOX2 maintains neural stem cell identity. However, its function in committed Müller glia has yet to be determined. METHODS: We use inducible, MG-specific genetic ablation of Sox2 in vivo at the peak of MG genesis to analyze its function in the maturation of murine MG and effects on other cells in the retina...
March 2016: Investigative Ophthalmology & Visual Science
Mariana Previato, Fábio Batista Frederico, Fernando Henrique Antunes Murata, Rubens Camargo Siqueira, Amanda Pires Barbosa, Aparecida Perpétuo Silveira-Carvalho, Cristina da Silva Meira, Vera Lúcia Pereira-Chioccola, Ricardo Gava, Plínio Pereira Martins Neto, Luiz Carlos de Mattos, Cinara Cássia Brandão de Mattos
BACKGROUND: Toxoplasmosis was recently included as a neglected disease by the Center for Disease Control. Ocular toxoplasmosis is one clinical presentation of congenital or acquired infection. The laboratory diagnosis is being used worldwide to support the clinical diagnosis and imaging. The aim of this study was to evaluate the use of serology and molecular methods to monitor acute OT in immunocompetent patients during treatment. METHODS: Five immunocompetent patients were clinically diagnosed with acute OT...
December 7, 2015: BMC Research Notes
Guo-Jie Ye, Thomas Conlon, Kirsten Erger, Peter Sonnentag, Alok K Sharma, Kellie Howard, David R Knop, Jeffrey D Chulay
Applied Genetic Technologies Corporation is developing a recombinant adeno-associated virus (rAAV) vector for treatment of X-linked retinoschisis (XLRS), an inherited retinal disease characterized by splitting (schisis) of the layers of the retina, which causes poor vision. We report here results of a study evaluating the safety and biodistribution of rAAV2tYF-CB-hRS1 in RS1-deficient mice. Three groups of male RS1-deficient mice received an intravitreal injection in one eye of either vehicle, or rAAV2tYF-CB-hRS1 at one of two dose levels (1 × 10(9) or 4 × 10(9) vg/eye) and were sacrificed 30 or 90 days later...
September 2015: Human Gene Therapy. Clinical Development
Richard F Spaide
PURPOSE: To investigate the retinal vascular findings and associated anatomic abnormalities in the central macula of eyes with diabetic retinopathy using volume-rendered angiographic and structural optical coherence tomography. STUDY DESIGN: Observational case series. METHODS: In this retrospective study 25 eyes of 14 consecutive patients were imaged with optical coherence tomography (OCT) using split-spectrum amplitude decorrelation. The structural OCT data were segmented for cystoid spaces and integrated into the angiographic data for subsequent volume rendering...
December 2015: American Journal of Ophthalmology
Susov Dhakal, Craig B Stevens, Meyrav Sebbagh, Omri Weiss, Ruth A Frey, Seth Adamson, Eric A Shelden, Adi Inbal, Deborah L Stenkamp
BACKGROUND: Functions for the early embryonic vasculature in regulating development of central nervous system tissues, such as the retina, have been suggested by in vitro studies and by in vivo manipulations that caused additional ocular vessels to develop. Here, we use an avascular zebrafish embryo, cloche-/- (clo-/-), to begin to identify necessary developmental functions of the ocular vasculature in regulating development and patterning of the neural retina, in vivo. These studies are possible in zebrafish embryos, which do not yet rely upon the vasculature for tissue oxygenation...
November 2015: Developmental Dynamics: An Official Publication of the American Association of Anatomists
Vera L Bonilha, Mary E Rayborn, Brent A Bell, Meghan J Marino, Craig D Beight, Gayle J Pauer, Elias I Traboulsi, Joe G Hollyfield, Stephanie A Hagstrom
PURPOSE: To evaluate the histopathology in donor eyes from patients with autosomal dominant retinitis pigmentosa (ADRP) caused by p.P23H, p.P347T and p.P347L rhodopsin ( RHO ) gene mutations. METHODS: Eyes from a 72-year-old male (donor 1), an 83-year-old female (donor 2), an 80-year-old female (donor 3), and three age-similar normal eyes were examined macroscopically, by scanning laser ophthalmoscopy and optical coherence tomography imaging. Perifoveal and peripheral pieces were processed for microscopy and immunocytochemistry with markers for photoreceptor cells...
December 2015: Graefe's Archive for Clinical and Experimental Ophthalmology
Luke Nicholson, Jayashree Ramu, Ioanna Triantafyllopoulou, Namritha V Patrao, Oliver Comyn, Philip Hykin, Sobha Sivaprasad
BACKGROUND: Disorganization of the retinal inner layers (DRIL) on optical coherence tomography (OCT) is thought to represent retinal capillary non-perfusion (CNP) in eyes with diabetic retinopathy. This study was designed to evaluate the ability of DRIL to accurately predict CNP. DESIGN: Retrospective masked reliability and diagnostic accuracy study performed in the National Institute for Health Research (NIHR) Moorfields Biomedical Research Centre, London, UK SAMPLES: Retinal images of patients with diabetic retinopathy METHODS: The OCT images from 90 separate areas of angiographically confirmed perfused and non-perfused areas of the macula from 37 eyes of 31 patients were anonymized and coded...
November 2015: Clinical & Experimental Ophthalmology
Salma H Radwan, Ahmed Z Soliman, Julian Tokarev, Lei Zhang, Frederik J van Kuijk, Dara D Koozekanani
IMPORTANCE: Macular edema (ME) prognosis and treatment response vary according to the underlying abnormalities. Biomarkers of visual acuity (VA) improvement could influence management decisions in different types of ME. OBJECTIVE: To investigate whether disorganization of retinal inner layers (DRIL) and other spectral-domain optical coherence tomography (SD-OCT)-derived variables are associated with subsequent VA after ME resolution in both nondiabetic and diabetic ME...
July 2015: JAMA Ophthalmology
Carol L Shields, Janet Manalac, Chandana Das, Jarin Saktanasate, Jerry A Shields
BACKGROUND: Spectral domain (SD) enhanced depth imaging optical coherence tomography (EDI-OCT) is a useful tool for anatomic, cross-sectional imaging of retinal conditions. AIMS: The aim was to identify characteristic patterns of retinal and retinal pigment epithelial tumors on EDI-OCT in children and adults. SETTINGS AND DESIGN: Retrospective review. MATERIALS AND METHODS: Analysis of published reports and personal observations using office-based EDI-OCT for adults and portable hand-held SD OCT for infants and children...
February 2015: Indian Journal of Ophthalmology
Yoko Dodo, Tomoaki Murakami, Akihito Uji, Shin Yoshitake, Nagahisa Yoshimura
PURPOSE: To investigate morphologic changes on spectral-domain optical coherence tomography (SD-OCT) images in nonperfused areas (NPAs) in diabetic retinopathy (DR). METHODS: One hundred eight consecutive eyes of 80 patients with diabetic ischemic maculopathy were retrospectively reviewed. The boundary between the nerve fiber layer (NFL) and the ganglion cell layer (GCL)/inner plexiform layer (IPL) and the status of Henle's layer were characterized on the vertical sectional images of SD-OCT...
March 2015: Investigative Ophthalmology & Visual Science
Jennifer K Sun, Salma H Radwan, Ahmed Z Soliman, Jan Lammer, Michael M Lin, Sonja G Prager, Paolo S Silva, Lloyd Bryce Aiello, Lloyd Paul Aiello
Despite treatment advances, diabetic eye disease remains a leading cause of visual acuity (VA) loss worldwide. No methods to prospectively determine which patients will gain or lose vision exist, limiting individualized risk assessment and management. We investigated whether noninvasive, readily obtainable spectral domain optical coherence tomography parameters were correlated with VA in eyes with current or resolved center-involved diabetic macular edema (DME). Images were evaluated for disorganization of the retinal inner layers (DRIL), cysts, epiretinal membranes, microaneurysms, subretinal fluid, and outer layer disruption/reflectivity...
July 2015: Diabetes
Orsolya Kántor, Alexandra Varga, Róbert Tóth, Anna Énzsöly, Emese Pálfi, Tamás Kovács-Öller, Roland Nitschke, Ágoston Szél, Andrea Székely, Béla Völgyi, László Négyessy, Zoltán Somogyvári, Ákos Lukáts
Tissue non-specific alkaline phosphatase (TNAP), an abundant ectophosphatase, is present in various organs including the brain and retina of several vertebrate species. Evidence is emerging that TNAP influences neural functions in multiple ways. In rat, strong TNAP activity has been found in retinal vessels, photoreceptors, and both synaptic layers. In the present study, we identified eleven strata of the inner plexiform layer (IPL) by using TNAP histochemistry alone. The TNAP strata corresponded exactly to the strata seen after combined immunohistochemistry with four canonical IPL markers (TH-ChAT-CR-PKCα)...
February 2015: Cell and Tissue Research
Stéphanie Baillif, Nathalie Tieulie, Viviane Queyrel, Pierre-Loïc Cornut, Pierre Gastaud
PURPOSE: To report the clinical, angiographic, and tomographic features of an adult patient with bilateral occlusive vasculitis and necrotizing retinitis preceding the onset of subacute sclerosing panencephalitis by 3 years. METHODS: Observational case report. RESULTS: A 39-year-old white man presented with sudden onset of decreased vision in his left eye. The patient reported a history of right visual loss 3 years ago after an episode of retinal vasculitis of unknown origin...
2012: Retinal Cases & Brief Reports
Delu Song, Steve Grieco, Yafeng Li, Allan Hunter, Sally Chu, Liangliang Zhao, Ying Song, Robert A DeAngelis, Lan-Ying Shi, Qin Liu, Eric A Pierce, Patsy M Nishina, John D Lambris, Joshua L Dunaief
Mutations in the RP1 gene can cause retinitis pigmentosa. We identified a spontaneous L66P mutation caused by two adjacent point mutations in the Rp1 gene in a colony of C57BL/6J mice. Mice homozygous for the L66P mutation exhibited slow, progressive photoreceptor degeneration throughout their lifespan. Optical coherence tomography imaging found abnormal photoreceptor reflectivity at 1 month of age. Histology found shortening and disorganization of the photoreceptor inner and outer segments and progressive thinning of the outer nuclear layer...
October 2014: American Journal of Pathology
Jennifer K Sun, Michael M Lin, Jan Lammer, Sonja Prager, Rutuparna Sarangi, Paolo S Silva, Lloyd Paul Aiello
IMPORTANCE: Biomarkers that predict future visual acuity (VA) in eyes with baseline diabetic macular edema (DME) would substantively improve risk assessment, management decisions, and selection of eyes for clinical studies targeting DME. OBJECTIVE: To determine whether baseline or early change in the novel spectral domain-optical coherence tomography (SD-OCT) parameter disorganization of the retinal inner layers (DRIL) is predictive of VA in eyes with center-involved DME...
November 2014: JAMA Ophthalmology
Mara Albert-Fort, José R Hombrebueno, Sheila Pons-Vazquez, Silvia Sanz-Gonzalez, Manuel Diaz-Llopis, María Dolores Pinazo-Durán
Insulin receptor substrate-2 (Irs2) mediates peripheral insulin action and is essential for retinal health. Previous investigations have reported severe photoreceptor degeneration and abnormal visual function in Irs2-deficient mice. However, molecular changes in the Irs2(-)(/)(-) mouse retina have not been described. In this study, we examined retinal degenerative changes in neuronal and glial cells of adult (9- and 12-week old) Irs2(-)(/)(-) mice by immunohistochemistry. 9-week old Irs2(-)(/)(-) mice showed significant thinning of outer retinal layers, concomitant to Müller and microglial cell activation...
July 2014: Experimental Eye Research
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