Abdel A Alli, Dhruv Desai, Ahmed Elshika, Marcus Conrad, Bettina Proneth, William Clapp, Carl Atkinson, Mark Segal, Louis A Searcy, Nancy D Denslow, Subhashini Bolisetty, Borna Mehrad, Laurence Morel, Yogesh Scindia
Ferroptosis is a druggable, iron-dependent form of cell death that is characterized by lipid peroxidation but has received little attention in lupus nephritis. Kidneys of lupus nephritis patients and mice showed increased lipid peroxidation mainly in the tubular segments and an increase in Acyl-CoA synthetase long-chain family member 4, a pro-ferroptosis enzyme. Nephritic mice had an attenuated expression of SLC7A11, a cystine importer, an impaired glutathione synthesis pathway, and low expression of glutathione peroxidase 4, a ferroptosis inhibitor...
December 22, 2022: Clinical Immunology: the Official Journal of the Clinical Immunology Society