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https://www.readbyqxmd.com/read/27588900/leptin-promotes-systemic-lupus-erythematosus-by-increasing-autoantibody-production-and-inhibiting-immune-regulation
#1
Elaine V Lourenço, Aijing Liu, Giuseppe Matarese, Antonio La Cava
Leptin is an adipocytokine that plays a key role in the modulation of immune responses and the development and maintenance of inflammation. Circulating levels of leptin are elevated in systemic lupus erythematosus (SLE) patients, but it is not clear whether this association can reflect a direct influence of leptin on the propathogenic events that lead to SLE. To investigate this possibility, we compared the extent of susceptibility to SLE and lupus manifestations between leptin-deficient (ob/ob) and H2-matched leptin-sufficient (wild-type, WT) mice that had been treated with the lupus-inducing agent pristane...
September 20, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27527599/opposing-roles-of-tyrosine-kinase-receptors-mer-and-axl-determine-clinical-outcomes-in-experimental-immune-mediated-nephritis
#2
Yuxuan Zhen, Stephen O Priest, Wen-Hai Shao
Glomerulonephritis is one of the most severe manifestations of systemic lupus erythematosus, with considerable morbidity and mortality. There remains a major unmet need for successful management of lupus nephritis. TAM family receptor tyrosine kinases (Mer and Axl) play an important role in the maintenance of immune homeostasis in the kidney. Mer is constitutively expressed in the glomeruli; Axl expression is inducible in glomeruli under inflammatory conditions. To investigate the distinct functions of Axl and Mer in lupus nephritis, we compared the severity of nephrotoxic serum glomerulonephritis in wild-type (WT), Axl-knockout (KO), Mer-KO, and Axl/Mer-KO mice...
September 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27468526/post-infectious-glomerulonephritis-in-pediatric-patients-over-two-decades-severity-associated-features
#3
Rona Dagan, Roxana Cleper, Miriam Davidovits, Levana Sinai-Trieman, Irit Krause
BACKGROUND: The incidence of post-infectious glomerulonephritis (PIGN) has decreased over the last decades. As a result, recent epidemiological data from industrialized countries are scarce. OBJECTIVES: To evaluate patterns of PIGN in children and detect possible predictors of disease severity. METHODS: We collected clinical and laboratory data of patients with PIGN admitted to Schneider Children's Medical Center during 1994-2011. Diagnostic criteria included presence of hematuria with/without other features of nephritic syndrome along with hypocomplementemia and/or microbiological/serological evidence of streptococcal infection...
June 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/27277365/presentation-and-treatment-outcomes-of-100-lupus-nephritis-patients-single-center-study
#4
M O Faroque, K M Hadiuzzaman, S F Islam, R M Hossain, M N Islam, A H Ahmed, P I Ahmed, M R Alam
Over a period of 3 years (January 2011 to December 2013) 100 cases of Lupus nephritis patients admitted in nephrology department of Bangabandhu Sheikh Mujib Medical University (BSMMU) were evaluated. Their clinical characteristics, biochemical parameters, renal histology according to WHO classification were categorized and their treatment modalities and outcome was observed. Among 100 patients, 84 were female and 16 were male, with F:M ratio 5:1. Mean age of female were 23±4 years and male were 29±4 years, mean BP in male was systolic 135±8 mmHg, diastolic 80±9mmHg and in female systolic was 130±7mmHg, diastolic 75±6 mmHg, mean Serum Creatinine for male was 180±12μmol/L and mean serum creatinine in female was 170±20μmol/L...
April 2016: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/27271566/plasticity-of-th17-cells-in-autoimmune-kidney-diseases
#5
Christian F Krebs, Jan-Eric Turner, Hans-Joachim Paust, Sonja Kapffer, Tobias Koyro, Sonja Krohn, Friederike Ufer, Manuel A Friese, Richard A Flavell, Brigitta Stockinger, Oliver M Steinmetz, Rolf A K Stahl, Samuel Huber, Ulf Panzer
The ability of CD4(+) T cells to differentiate into pathogenic Th1 and Th17 or protective T regulatory cells plays a pivotal role in the pathogenesis of autoimmune diseases. Recent data suggest that CD4(+) T cell subsets display a considerable plasticity. This plasticity seems to be a critical factor for their pathogenicity, but also for the potential transition of pathogenic effector T cells toward a more tolerogenic phenotype. The aim of the current study was to analyze the plasticity of Th17 cells in a mouse model of acute crescentic glomerulonephritis and in a mouse chronic model of lupus nephritis...
July 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27215250/clinicopathological-correlations-of-renal-pathology-a-single-center-experience
#6
Mabrouk I Ismail, Khaled Lakouz, Eman Abdelbary
To evaluate the clinicopathological correlation of renal pathology and outline the frequencies of different renal diseases, beside assessment of lupus nephritis (LN), we studied 150 patients [72 (48%) males and mean age of 33.82 ± 15.4 years] who were subjected to native renal biopsy; 112 (72.8%) biopsied patients were diagnosed to have glomerulonephritis (GN). The most frequent clinical renal syndrome was nephrotic syndrome found in 55 (36.6%) patients, followed by nephritic syndrome in 38 (25.3%) patients, chronic kidney disease in 28 (18...
May 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27194835/frequency-of-kidney-diseases-and-clinical-indications-of-pediatric-renal-biopsy-a-single-center-experience
#7
S Imtiaz, K Nasir, M F Drohlia, B Salman, A Ahmad
Kidney biopsy occupies a fundamental position in the management of kidney diseases. There are very few renal pathology studies available in the literature from developing world. This study scrutinized the frequency and clinicopathological relationship of kidney biopsies done at the kidney center from 1997 to 2013 amongst pediatric patients. Kidney allograft biopsy were excluded. The specimen was examined under light microscopy and immunofluorescence while electron microscopy was not done. The study includes 423 patients, mean age was 10...
May 2016: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/27146825/testing-the-activity-of-complement-convertases-in-serum-plasma-for-diagnosis-of-c4nef-mediated-c3-glomerulonephritis
#8
Anna M Blom, Fernando Corvillo, Michal Magda, Grzegorz Stasiłojć, Pilar Nozal, Miguel Ángel Pérez-Valdivia, Virginia Cabello-Chaves, Santiago Rodríguez de Córdoba, Margarita López-Trascasa, Marcin Okrój
Autoantibodies termed C3-nephritic factor (C3NeF), which stabilize convertases of the alternative complement pathway, often stimulate autoinflammatory diseases. However, knowledge about analogous autoantibodies acting on the classical pathway (C4NeF) is limited to a few reports, which indicate association with kidney dysfunction, systemic lupus erythematous, and infections. C4NeF may appear independently from C3NeF, but the lack of a routine diagnostic method predisposes C4NeF for being an underestimated player in autoinflammatory episodes...
July 2016: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/27075795/parvovirus-b19-induced-lupus-like-syndrome-with-nephritis
#9
Elodie Georges, Zuzana Rihova, Radek Cmejla, Pierre-Yves Decleire, Corinne Langen
We report a case of a 65-year-old man who developed an acute illness with fever, arthralgia and nephritic syndrome. Antinuclear antibodies were slightly positive and complement levels were low. Renal biopsy showed exudative diffuse proliferative endocapillary glomerulonephritis with diffuse immunoglobulin (IgG, IgA, IgM) and complement deposition (C3d, C4d, C1q) on immunofluorescence. The patient was first treated with corticosteroids and mycophenolate mofetil for suspected lupus with WHO class IV glomerulonephritis...
December 2016: Acta Clinica Belgica
https://www.readbyqxmd.com/read/27051973/blisibimod-for-treatment-of-systemic-lupus-erythematosus-with-trials-you-become-wiser
#10
Morton A Scheinberg, Colin M Hislop, Renee S Martin
INTRODUCTION: Blisibimod is a potent and selective inhibitor of B cell activating factor (BAFF), a mediator of differentiation, maturation and survival of B cells. It has a unique tetravalent, 'peptibody' structure and resulting high potency, and is currently in clinical evaluation for the treatment of SLE. The importance of BAFF in the pathogenesis of systemic lupus erythematosus (SLE) is under intense investigation. The anti BAFF monoclonal antibody belimumab was approved by the FDA for the treatment of SLE...
2016: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/27049363/frequency-and-clinical-histological-analysis-of-glomerular-diseases-in-a-tertiary-hospital-in-southern-brazil
#11
Camila Crensiglova, Bárbara Benevides Rehme, Letícia Raysa Schiavon Kinasz, Domingos Candiota Chula, Marcelo Mazza do Nascimento, Maria Fernanda Sanches Soares
INTRODUCTION: The glomerulopathies are the most common biopsy-proven kidney diseases. The epidemiological investigation of glomerulopathies allows the identification of their distribution and main causes and enables the development of prevention and treatment strategies. OBJECTIVE: This study aims to identify the frequency and clinical-pathological correlation of glomerular diseases diagnosed at the HC-UFPR over the period of 5 years. METHODS: 131 biopsies were performed between January 1, 2008 and December 31, 2012 and were analysed by light and immunofluorescence microscopy...
March 2016: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/26879422/clinical-and-pathologic-considerations-of-the-qualitative-and-quantitative-aspects-of-lupus-nephritogenic-autoantibodies-a-comprehensive-review
#12
REVIEW
Mariele Gatto, Luca Iaccarino, Anna Ghirardello, Leonardo Punzi, Andrea Doria
Autoantibodies are key mediators in determining the clinical manifestations of systemic lupus erythematosus (SLE). The mechanisms by which antibodies may be harmful to self tissues encompass complement mediated inflammation, cell apoptosis and immune-complexes mediated damage, however the precise cooperation of antibodies in SLE have not been unravelled so far. Lupus nephritis (LN) is a protean feature of SLE resulting in wide variety of symptoms including asymptomatic proteinuria, mild renal disease until end-stage renal failure which are triggered by complex autoantibody interactions...
May 2016: Journal of Autoimmunity
https://www.readbyqxmd.com/read/26856980/insight-to-changing-morphologic-patterns-of-glomerulopathy-in-adult-pakistani-patients-an-institutional-perspective
#13
Atif Ali Hashmi, ZubaidaFida Hussain, Muhammad Muzzammil Edhi, Shazia Mumtaz, Naveen Faridi, Mehmood Khan
BACKGROUND: Idiopathic nephrotic syndrome encompasses diverse histogenetic patterns and depicts socioeconomic and demographic differences attributable to genetic profile, environmental factors and prevalence of infectious diseases. A lack of renal registry in our country necessitates a need to document changing histologic patterns of nephrotic syndrome as noted in different parts of the world. METHODS: We retrospectively analyzed 140 patients who underwent renal biopsy at Liaquat National Hospital from January 2009 to December 2013 over a period of 3 years...
2016: BMC Research Notes
https://www.readbyqxmd.com/read/26538397/fli1-levels-impact-cxcr3-expression-and-renal-infiltration-of-t-cells-and-renal-glycosphingolipid-metabolism-in-the-mrl-lpr-lupus-mouse-strain
#14
Kamala P Sundararaj, Thirumagal Thiyagarajan, Ivan Molano, Fahmin Basher, Thomas W Powers, Richard R Drake, Tamara K Nowling
The ETS factor Friend leukemia virus integration 1 (FLI1) is a key modulator of lupus disease expression. Overexpressing FLI1 in healthy mice results in the development of an autoimmune kidney disease similar to that observed in lupus. Lowering the global levels of FLI1 in two lupus strains (Fli1(+/-)) significantly improved kidney disease and prolonged survival. T cells from MRL/lpr Fli1(+/-) lupus mice have reduced activation and IL-4 production, neuraminidase 1 expression, and the levels of the glycosphingolipid lactosylceramide...
December 15, 2015: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/26528443/pediatric-renal-biopsies-in-india-a-single-centre-experience-of-six-years
#15
Kamal V Kanodia, Aruna V Vanikar, Lovelesh K Nigam, Rashmi D Patel, Kamlesh S Suthar, Dinesh N Gera, Hargovind L Trivedi
BACKGROUND: Renal biopsy is a well-established diagnostic modality for the assessment of kidney diseases in children. It can provide diagnostic precision and prognostic value and guide in therapeutic options for many renal diseases. OBJECTIVES: This report describes the indication, histopathological patterns, and epidemiology of renal diseases in children in India. PATIENTS AND METHODS: This is a single-center study on renal biopsies performed between January 2008 and December 2013 in 346 children (age ≤ 14 years)...
July 2015: Nephro-urology Monthly
https://www.readbyqxmd.com/read/26405028/renal-flare-prediction-and-prognosis-in-lupus-nephritis-hispanic-patients
#16
J M Mejía-Vilet, B M Córdova-Sánchez, J M Arreola-Guerra, L E Morales-Buenrostro, N O Uribe-Uribe, R Correa-Rotter
We performed a retrospective cohort analysis focusing on lupus nephritis renal flare incidence and outcome predictors. One hundred and eighteen patients with biopsy-proven lupus nephritis were segregated by induction/maintenance regimes. The primary outcome was the proportion of patients experiencing renal flare. Secondary assessment included doubling of serum creatinine and development of end-stage renal disease. After a median follow-up of 31 months (interquartile range 21-46) from the date of response to induction therapy, 47 patients (39...
March 2016: Lupus
https://www.readbyqxmd.com/read/26357965/anti-c1q-antibody-in-patients-with-lupus-nephritic-flare-18-month-follow-up-and-a-nested-case-control-study
#17
Alimohammad Fatemi, Golnaz Samadi, Zahra Sayedbonakdar, Abbas Smiley
OBJECTIVES: A prospective cohort was conducted to investigate the association of anti-C1q antibody and lupus/lupus nephritis (LN) flare. METHODS: Sixty-nine consecutive patients with systemic lupus erythematosus were enrolled and followed up for 18 months. Anti-C1q was recorded at the first visit and at the time of flare. For patients with flare, age and sex matched SLE patients were considered as the control group (nested case-control study). The predictability of anti-C1q and other laboratory indices for LN flare during the 18-month follow-up was calculated...
2016: Modern Rheumatology
https://www.readbyqxmd.com/read/26354589/kidney-biopsy-in-the-military-hospital-of-morocco-complications-and-histopathological-findings
#18
Yassir Zajjari, Taoufiq Aatif, Abdelali Bahadi, Kawtar Hassani, Driss El Kabbaj, Mohamed Benyahia
Epidemiological studies on renal biopsies are necessary to establish the pattern and trends of renal diseases in a particular geographic area. In this retrospective study, we reviewed the medical records, histopathology findings and complications of renal biopsy in a region of Morocco. We studied a total of 130 native kidney biopsies taken between January 2008 and January 2012. All biopsies were examined by light microscopy and immunofluorescence microscopy. There were 86 males (66.2%) and 44 females (33.8%), with a mean patient age of 44...
September 2015: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/26281194/-impact-of-interleukin-10-and-interleukin-28-gene-polymorphisms-on-the-development-and-course-of-lupus-nephritis
#19
T N Krasnova, L M Samokhodskaia, L V Ivaninitskiĭ, A D Korogodina, E N Borisov, N V Nikiforova, P I Novikov, A A Kamalov, N A Mukhin
AIM: To assess the relationship of the carriage of IL-10-1080 G/A and IL-28 rs8099917 C/T polymorphisms to the course of lupus nephritis (LN). SUBJECTS AND METHODS: Ninety-nine patients with systemic lupus erythematosus (SLE), including 68 with LN, were examined. Gene polymorphisms were analyzed using standard molecular genetic techniques. The frequency of the clinical manifestations of LN was analyzed; renal survival (RS) was estimated by the Kaplan-Meier method...
2015: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/26268365/a-subset-of-patients-with-systemic-lupus-erythematosus-fails-to-degrade-dna-from-multiple-clinically-relevant-sources
#20
Jonatan Leffler, Katarzyna Ciacma, Birgitta Gullstrand, Anders A Bengtsson, Myriam Martin, Anna M Blom
INTRODUCTION: Patients with systemic lupus erythematosus (SLE) have a decreased ability to clear cell remnants and multiple deficiencies in the ability to degrade cellular chromatin have been linked to the disease. Since the discovery of neutrophil extracellular traps (NETs), a renewed interest has been sparked in this field of research with multiple studies reporting a decreased ability of patients with SLE to degrade NETs. In this study we extend these findings by investigating the ability of patients with SLE to degrade chromatin from multiple clinically relevant sources...
2015: Arthritis Research & Therapy
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