Zhenliang Wen, Hui Li, Chenghua Zhou, Limin Chen, Lidi Zhang, Yizhu Chen, Sheng Zhang, Xiaojun Pan, Sisi Huang, Weifeng Shang, Xuan Shen, Yongan Liu, Jiao Liu, Dechang Chen
Immune dysfunction is one of the leading causes of death of sepsis. How to regulate host immune functions to improve prognoses of septic patients has always been a clinical focus. Here we elaborate on the efficacy and potential mechanism of a classical drug, thymopentin (TP5). TP5 could decrease peritoneal bacterial load, and reduce inflammatory cytokine levels both in the peritoneal lavage fluid (PLF) and serum, alleviate pathological injuries in tissue and organ, coaxed by cecal ligation and perforation (CLP) in mice, ultimately improve the prognosis of septic mice...
December 3, 2023: International Immunopharmacology