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https://www.readbyqxmd.com/read/29240312/garden-terror-case-series-of-twenty-eight-serious-ear-injuries-caused-by-yucca-plants
#1
Maria Vartanyan, Kumiko Orimoto, Adrian Dragovic, Carmel Crock, Michael Dobson, Stephen O'Leary
The yucca plant (genus Yucca, family Asparagaceae, subfamily Agavoideae) is a ubiquitous plant whose long and sharp leaf spines (Fig 1) are accountable for an increasing number of ear injuries presenting to the Emergency Department of our specialised tertiary hospital. Whereas most cases presented as easy-to-diagnose traumatic tympanic membrane perforations (TMP) which healed quickly, 4 cases were complicated by perilymphatic fistula (PLF), and these presented a diagnostic dilemma that resulted in late diagnoses...
December 14, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29238638/efficacy-of-early-fusion-with-local-bone-graft-and-platelet-rich-plasma-in-lumbar-spinal-fusion-surgery-followed-over-10-years
#2
Shiro Imagama, Kei Ando, Kazuyoshi Kobayashi, Yoshimoto Ishikawa, Hiroshi Nakamura, Tetsuro Hida, Kenyu Ito, Mikito Tsushima, Akiyuki Matsumoto, Masayoshi Morozumi, Satoshi Tanaka, Masaaki Machino, Kyotaro Ota, Hiroaki Nakashima, Junki Takamatsu, Tadashi Matsushita, Yoshihiro Nishida, Naoki Ishiguro, Yukihiro Matsuyama
Study Design: Prospective clinical study. Objective: Many oral surgeons use platelet-rich plasma (PRP) for bone defects, but the efficacy of PRP for spinal arthrodesis remains uncertain. The objective was to compare the efficacy of autologous local bone graft and PRP with local bone graft alone for promotion of bony union in posterolateral lumbar fusion (PLF) surgery, with investigation of the safety of PRP over 10 years. Methods: A prospective study was conducted in 29 consecutive patients who underwent one-level PLF at L4/5 for degenerative lumbar disease...
December 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29237821/sequential-actions-of-phosphatidylinositol-phosphates-regulate-phagosome-lysosome-fusion
#3
Andreas Jeschke, Albert Haas
Phagosomes mature into phagolysosomes by sequential fusion with early endosomes, late endosomes, and lysosomes. Phagosome-with-lysosome fusion (PLF) results in the delivery of lysosomal hydrolases into phagosomes and in digestion of the cargo. The machinery that drives PLF has been little investigated. Using a cell-free system, we recently identified the phosphoinositide lipids (PIPs) phosphatidylinositol 3-phosphate [PI(3)P] and phosphatidylinositol 4-phosphate [PI(4)P] as regulators of PLF. We now report the identification and the PIP requirements of four distinct sub-reactions of PLF...
December 13, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29155341/outpatient-elective-posterior-lumbar-fusions-appear-to-be-safely-considered-for-appropriately-selected-patients
#4
Patawut Bovonratwet, Taylor D Ottesen, Raj J Gala, Daniel R Rubio, Nathaniel T Ondeck, Ryan P McLynn, Jonathan N Grauer
BACKGROUND CONTEXT: There has been growing interest in performing posterior lumbar fusions (PLFs) in the outpatient setting to optimize patient satisfaction and reduce cost. Although still done in only a small percentage of cases, this has been more possible because of advances in surgical techniques and anesthesia. However, data on the perioperative course of outpatient compared with inpatient PLF in a large sample size are scarce. PURPOSE: This study aimed to compare perioperative complications between outpatient and inpatient PLF in the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database...
November 16, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29155116/the-effect-of-steroids-on-complications-readmission-and-reoperation-after-posterior-lumbar-fusion
#5
Michael B Cloney, Roxanna M Garcia, Zachary A Smith, Nader S Dahdaleh
BACKGROUND DATA: The effects of chronic corticosteroid therapy on complications, readmission, and reoperation after posterior lumbar fusion (PLF) remains under-investigated and was examined to determine differences in outcomes. METHODS: We analyzed patients from 2006 to 2013 using the National Surgery Quality Improvement Program database (NSQIP) undergoing PLF. Patients taking steroids for a chronic condition were compared to those not taking steroids. Multivariable regression identified factors independently associated with complications, readmission, and reoperation...
November 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29122427/transcanal-endoscopic-ear-surgery-for-perilymphatic-fistula-after-electric-acoustic-stimulation
#6
Ryotaro Omichi, Shin Kariya, Yukihide Maeda, Kazunori Nishizaki
Transcanal endoscopic ear surgery (TEES) will become a very useful therapeutic option. A perilymphatic fistula (PLF) is defined as sudden sensorineural hearing loss and/or vertigo caused by leakage of the perilymph through a fistula from the oval window and/or round window. We report a case of PLF after electric acoustic stimulation (EAS), a kind of cochlear implant, successfully treated by TEES. A 38-year-old man presented to our hospital with vertigo and hearing loss (HL). His vertigo was induced by Valsalva maneuvers...
November 6, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29065422/acute-phencyclidine-alters-neural-oscillations-evoked-by-tones-in-the-auditory-cortex-of-rats
#7
Ashley M Schnakenberg Martin, Brian F OʼDonnell, James B Millward, Jenifer L Vohs, Emma Leishman, Amanda R Bolbecker, Olga Rass, Sandra L Morzorati
BACKGROUND/AIMS: The onset response to a single tone as measured by electroencephalography (EEG) is diminished in power and synchrony in schizophrenia. Because neural synchrony, particularly at gamma frequencies (30-80 Hz), is hypothesized to be supported by the N-methyl-D-aspartate receptor (NMDAr) system, we tested whether phencyclidine (PCP), an NMDAr antagonist, produced similar deficits to tone stimuli in rats. METHODS: Experiment 1 tested the effect of a PCP dose (1...
October 24, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/29055738/the-utility-of-preoperative-labs-in-predicting-postoperative-complications-following-posterolateral-lumbar-fusion
#8
Nikita Lakomkin, Vadim Goz, Joseph S Cheng, Darrel S Brodke, William Ryan Spiker
BACKGROUND CONTEXT: Several studies have suggested that lab results have minimal impact on clinical decision-making in surgery. Despite the widespread use of preoperative testing in spine surgery and the large volume of posterolateral lumbar fusions (PLFs) being performed each year, no study has assessed the ability of preoperative labs to predict adverse events following PLF. PURPOSE: The purpose of this study was to explore the relationship between commonly obtained preoperative lab results and postoperative complications following 1-2 level PLF...
October 18, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29055686/the-role-of-explorative-tympanotomy-in-patients-with-sudden-sensorineural-hearing-loss-with-and-without-perilymphatic-fistula
#9
REVIEW
N K Prenzler, B Schwab, D M Kaplan, S El-Saied
PURPOSE: The purpose of this study was to describe the role of explorative tympanotomy in patients with Profound Sudden Sensorineural Hearing Loss (SSNHL) without clinical evidence of perilymphatic or labyrinthine fistula and to compare intraoperative findings with the postoperative hearing outcome. STUDY DESIGN: Retrospective study of all patients diagnosed with SSNHL who underwent explorative tympanotomy between 2002 and 2005. SETTINGS: Tertiary care university-affiliated hospital...
October 9, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29047242/effect-of-sagittal-balance-on-risk-of-falling-after-lateral-lumbar-interbody-fusion-surgery-combined-with-posterior-surgery
#10
Byung Ho Lee, Jae Ho Yang, Hak Sun Kim, Kyung Soo Suk, Hwan Mo Lee, Jin Oh Park, Seong Hwan Moon
PURPOSE: To demonstrate the impact of correcting sagittal balance (SB) on functional outcomes of surgical treatment for degenerative spinal disease and actual falls via utilization of new minimally invasive lumbar fusion techniques via a lateral approach. MATERIALS AND METHODS: From November 2011 to March 2015, we enrolled 56 patients who underwent minimally invasive lateral lumbar interbody fusion (LLIF) and matched 112 patients receiving decompression/postero-lateral fusion (PLF) surgery for lumbar spinal stenosis...
November 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29017299/variation-of-c-reactive-protein-and-white-blood-cell-counts-in-spinal-operation-primary-fusion-surgery-versus-revision-fusion-surgery
#11
Kyung Tag Kang, Dong Wuk Son, Su Hun Lee, Geun Seong Song, Soon Ki Sung, Sang Weon Lee
OBJECTIVE: Serum C-reactive protein (CRP) concentrations and white blood cell (WBC) count are commonly used to identify postoperative wound infections. We investigated whether changes in serum CRP levels and WBC counts actually differed between patients undergoing revision spinal fusion surgery and those undergoing a primary fusion. METHODS: Patients who underwent posterolateral fusion (PLF) surgery at Pusan National University Yangsan Hospital between October 2013 and April 2015 were considered for this study...
September 2017: Korean Journal of Spine
https://www.readbyqxmd.com/read/28930913/the-effect-of-lactoferrin-and-pepsin-treated-lactoferrin-on-iec-6-cell-damage-induced-by-clostridium-difficile-toxin-b
#12
Kosuke Otake, Norio Sato, Ayako Kitaguchi, Takayuki Irahara, Satoru Murata, Keiichiro Shiraga, Yuichi Ogawa, Takahiro K Fujiwara, Kaoru Koike, Hiroyuki Yokota
Clostridium difficile infections (CDI) have recently increased worldwide. Some CDI progress to fulminant and recurrent CDI and are associated with high mortality and morbidity. CD produces toxins A and B, which cause intestinal mucosal damage, although toxin B exhibits greater cytotoxicity. Pepsin-treated lactoferrin (PLF) is the decomposed product of lactoferrin (LF), a multifunctional glycoprotein with anti-inflammatory properties. Here, we investigate the effects of LF and PLF in toxin B-stimulated rat intestinal epithelial (IEC-6) cells...
September 19, 2017: Shock
https://www.readbyqxmd.com/read/28928659/brain-pharmacokinetics-and-the-pharmacological-effects-on-striatal-neurotransmitter-levels-of-pueraria-lobata-isoflavonoids-in-rat
#13
Bingxin Xiao, Zengxian Sun, Fangrui Cao, Lisha Wang, Yonghong Liao, Xinmin Liu, Ruile Pan, Qi Chang
Isoflavonoids are putatively active components of Pueraria lobata and has been demonstrated prominent neuro-protection effect against cerebrovascular disorders, hypertension or Parkinson's disease (PD). However, the molecular basis for the beneficial effect of Pueraria lobata on nervous systems has not been well revealed. The present study aims to assess striatum exposure to main active isoflavonoids and changes of striatal extracellular neurotransmitters levels in rat brain after intravenous administration of Pueraria lobata isoflavonoids extracts (PLF), to further elucidate its' substantial bases for neuro activities...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28834899/predicting-the-risk-of-postoperative-liver-failure-and-overall-survival-using-liver-and-spleen-stiffness-measurements-in-patients-with-hepatocellular-carcinoma
#14
Dongbo Wu, Enqiang Chen, Tao Liang, Menglan Wang, Bin Chen, Bai Lang, Hong Tang
Postoperative liver failure (PLF) is the primary cause of morbidity and mortality after hepatic resection for hepatocellular carcinoma (HCC). In this study, we evaluated the efficacy of liver stiffness (LS) and spleen stiffness (SS), as measured by transient elastography (TE), for predicting the risk of PLF and overall survival (OS) in these patients.This prospective cohort study included 54 patients diagnosed with HCC who underwent hepatic resection between March 2013 and March 2014. Preoperative measurement of LS and SS using TE was performed on all patients underwent...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28811993/posterolateral-fusion-versus-interbody-fusion-for-degenerative-spondylolisthesis-systematic-review-and-meta-analysis
#15
REVIEW
Ryan C Campbell, Ralph J Mobbs, Victor M Lu, Joshua Xu, Prashanth J Rao, Kevin Phan
STUDY DESIGN: Systematic review and meta-analysis. OBJECTIVE: Current surgical management of degenerative spondylolisthesis (DS) involves decompression of the spinal canal followed by fusion with or without interbody. The additional functional and operative benefits derived from interbody inclusion has yet to be thoroughly established with a number of recent studies producing conflicting results. Thus, we aim to compare the functional and operative outcomes after fusion against interbody fusion in the treatment of DS...
August 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28808772/longitudinal-strain-assessed-by-cardiac-magnetic-resonance-correlates-to-hemodynamic-findings-in-patients-with-severe-aortic-stenosis-and-predicts-positive-remodeling-after-transcatheter-aortic-valve-replacement
#16
Dominik Buckert, Maciej Cieslik, Raid Tibi, Michael Radermacher, Volker Rasche, Peter Bernhardt, Vinzenz Hombach, Wolfgang Rottbauer, Jochen Wöhrle
AIMS: To assess left-ventricular strain parameters before and after transcatheter aortic valve replacement (TAVR) by feature tracking cardiac magnetic resonance imaging (FT CMR) and to correlate the findings to hemodynamic state and left-ventricular remodeling. METHODS AND RESULTS: Patients with symptomatic AS underwent FT CMR before and after TAVR. Patients were carefully evaluated by a comprehensive work-up including CMR, echocardiography and left and right heart catheterization...
August 14, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28808602/high-lumbar-noninstrumented-fusion-rates-using-lamina-autograft-and-nanoss-bone-marrow-aspirate
#17
Nancy E Epstein
BACKGROUND: Patients with marked osteoporosis and/or obesity/morbid obesity and severe multilevel lumbar stenosis and other pathology often undergo multilevel laminectomies with non instrumented posterolateral fusions (PLF). The other pathology may include combinations of degenerative spondylolisthesis/lysis, foraminal/far lateral discs, and/or synovial cysts requiring more extensive facet resections. Presently, spine surgeons often use bone graft expanders to supplement the lamina autograft harvested in the course of laminectomy/decompressions for the PLF mass...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28746129/comparison-of-posterior-lumbar-interbody-fusion-versus-posterolateral-fusion-for-the-treatment-of-isthmic-spondylolisthesis
#18
Jiaquan Luo, Kai Cao, Ting Yu, Liangping Li, Sheng Huang, Ming Gong, Cong Cao, Xuenong Zou
STUDY DESIGN: Systematic review and meta-analysis. BACKGROUND: Posterolateral fusion (PLF) and posterior lumbar interbody fusion (PLIF) were widely used in the treatment of lumbar isthmic spondylolisthesis (IS). There was a great controversy over the preferred fusion method. OBJECTIVE: The purpose of this study is to evaluate the clinical outcomes between PLF and PLIF for the treatment of IS. MATERIALS AND METHODS: Related studies that compared the clinical effectiveness of PLIF and PLF for the treatment of IS were acquired by a comprehensive search in 4 electronic databases (PubMed, EMBASE, Cochrane Controlled Trial Register, and MEDLINE) from January 1950 through December 2014...
August 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28739387/effect-of-cortex-mori-on-pharmacokinetic-profiles-of-main-isoflavonoids-from-pueraria-lobata-in-rat-plasma
#19
Bingxin Xiao, Zengxian Sun, Shu Yang Sun, Jie Dong, Yanli Li, Shan Gao, Jie Pang, Qi Chang
ETHNOPHARMACOLOGICAL RELEVANCE: Radix pueraria (the root of pueraria lobata (Wild.) Ohwi.), which contains a class of isoflavonoids as the main active components, as well as cortex mori (the root bark of Morus alba L), which contains abundant active alkaloids, have been employed for the treatment of diabetes in traditional Chinese medicine for centuries. In previous studies, pharmacodynamic synergistic reactions have been observed in compatible application of pueraria lobata isoflavonoids extracts (PLF) and cortex mori alkaloids extracts (CME) for inhibiting α-glycosidase activity...
July 21, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28735763/platelet-rich-plasma-enhances-bone-union-in-posterolateral-lumbar-fusion-a-prospective-randomized-controlled-trial
#20
Go Kubota, Hiroto Kamoda, Sumihisa Orita, Kazuyo Yamauchi, Yoshihiro Sakuma, Yasuhiro Oikawa, Kazuhide Inage, Takeshi Sainoh, Jun Sato, Michihiro Ito, Masaomi Yamashita, Junichi Nakamura, Takane Suzuki, Kazuhisa Takahashi, Seiji Ohtori
BACKGROUND CONTEXT: Platelet-rich plasma (PRP) accelerates bone union in vivo in a rodent model of spinal fusion surgery. However, PRP's effect on bone union after spinal surgery remains unclear. PURPOSE: The objective of this study was to evaluate the efficacy of PRP after posterolateral lumbar fusion (PLF) surgery. STUDY DESIGN/SETTING: Single-center prospective randomized controlled clinical trial with 2-year follow-up. PATIENT SAMPLE: The patient sample included a total 62 patients (31 patients in the PRP group or 31 patients in the control group)...
July 20, 2017: Spine Journal: Official Journal of the North American Spine Society
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