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https://www.readbyqxmd.com/read/28746129/comparison-of-posterior-lumbar-interbody-fusion-versus-posterolateral-fusion-for-the-treatment-of-isthmic-spondylolisthesis
#1
Jiaquan Luo, Kai Cao, Ting Yu, Liangping Li, Sheng Huang, Ming Gong, Cong Cao, Xuenong Zou
STUDY DESIGN: Systematic review and meta-analysis. BACKGROUND: Posterolateral fusion (PLF) and posterior lumbar interbody fusion (PLIF) were widely used in the treatment of lumbar isthmic spondylolisthesis (IS). There was a great controversy over the preferred fusion method. OBJECTIVE: The purpose of this study is to evaluate the clinical outcomes between PLF and PLIF for the treatment of IS. MATERIALS AND METHODS: Related studies that compared the clinical effectiveness of PLIF and PLF for the treatment of IS were acquired by a comprehensive search in 4 electronic databases (PubMed, EMBASE, Cochrane Controlled Trial Register, and MEDLINE) from January 1950 through December 2014...
August 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28739387/effect-of-cortex-mori-on-pharmacokinetic-profiles-of-main-isoflavonoids-from-pueraria-lobata-in-rat-plasma
#2
Bingxin Xiao, Zengxian Sun, Shu Yang Sun, Jie Dong, Yanli Li, Shan Gao, Jie Pang, Qi Chang
ETHNOPHARMACOLOGICAL RELEVANCE: Radix pueraria (the root of pueraria lobata (Wild.) Ohwi.), which contains a class of isoflavonoids as the main active components, as well as cortex mori (the root bark of Morus alba L), which contains abundant active alkaloids, have been employed for the treatment of diabetes in traditional Chinese medicine for centuries. In previous studies, pharmacodynamic synergistic reactions have been observed in compatible application of pueraria lobata isoflavonoids extracts (PLF) and cortex mori alkaloids extracts (CME) for inhibiting α-glycosidase activity...
July 21, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28735763/platelet-rich-plasma-enhances-bone-union-in-posterolateral-lumbar-fusion-a-prospective-randomized-controlled-trial
#3
Go Kubota, Hiroto Kamoda, Sumihisa Orita, Kazuyo Yamauchi, Yoshihiro Sakuma, Yasuhiro Oikawa, Kazuhide Inage, Takeshi Sainoh, Jun Sato, Michihiro Ito, Masaomi Yamashita, Junichi Nakamura, Takane Suzuki, Kazuhisa Takahashi, Seiji Ohtori
BACKGROUND CONTEXT: Platelet-rich plasma (PRP) accelerates bone union in vivo in a rodent model of spinal fusion surgery. However, PRP's effect on bone union after spinal surgery remains unclear. PURPOSE: To evaluate the efficacy of PRP after posterolateral lumbar fusion (PLF) surgery. STUDY DESIGN/SETTING: Single-center prospective randomized controlled clinical trial with 2-year follow-up. PATIENT SAMPLE: Total 62 patients (31 patients in PRP group or 31 patients in control groups OUTCOME MEASURES: Bone fusion rate, area of bone fusion mass, duration for bone fusion, and clinical score using visual analog scale (VAS)...
July 20, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28735430/approaches-and-fixation-of-the-posterolateral-fracture-fragment-in-tibial-plateau-fractures-a-review-with-an-emphasis-on-rim-plating-via-modified-anterolateral-approach
#4
REVIEW
Jae-Woo Cho, Jinil Kim, Won-Tae Cho, Jin-Kak Kim, Puspak Samal, Pranay H Gujjar, William T Kent, Jong-Keon Oh
PURPOSE: To review available approaches and fixation methods for posterolateral fracture fragment (PLF) in tibial plateau fracture, and to propose an algorithm to treat various types of plateau fractures which all involve the PLF. METHODS: This article reviews multiple surgical approaches for PLF and suggests an algorithm for suitable approach and fixation method according to PLF with combined plateau fracture. RESULTS: The modified anterolateral approach is a suitable single approach for fractures with a PLF combined with an anterolateral plateau fracture and for isolated posterolateral fracture fragments...
July 22, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28705683/periodontal-ligament-fibroblasts-as-a-cell-model-to-study-osteogenesis-and-osteoclastogenesis-in-fibrodysplasia-ossificans-progressiva
#5
Teun J de Vries, Ton Schoenmaker, Dimitra Micha, Jolanda Hogervorst, Siham Bouskla, Tim Forouzanfar, Gerard Pals, Coen Netelenbos, E Marelise W Eekhoff, Nathalie Bravenboer
Fibrodysplasia Ossificans Progressiva (FOP) is a progressive disease characterized by periods of heterotopic ossification of soft connective tissues, including ligaments. Though progress has been made in recent years in unraveling the underlying mechanism, patient-derived cell models are necessary to test potential treatment options. Periodontal ligament fibroblasts (PLF) from extracted teeth can be used to study deviant bone modeling processes in vitro since these cells are derived from genuine ligaments. They further provide a tool to study the hitherto unknown role of the bone morphogenesis protein receptor type 1 (BMPR-1) Activin A type 1 receptor ACVR1-R206H mutation in osteoclastogenesis...
July 10, 2017: Bone
https://www.readbyqxmd.com/read/28697772/injectable-and-compression-resistant-low-viscosity-polymer-ceramic-composite-carriers-for-rhbmp-2-in-a-rabbit-model-of-posterolateral-fusion-a-pilot-study
#6
Stefanie M Shiels, Anne D Talley, Madison A P McGough, Katarzyna J Zienkiewicz, Kerem Kalpakci, Daniel Shimko, Scott A Guelcher, Joseph C Wenke
BACKGROUND: The challenging biological and mechanical environment of posterolateral fusion (PLF) requires a carrier that spans the transverse processes and resists the compressive forces of the posterior musculature. The less traumatic posterolateral approach enabled by minimally invasive surgical techniques has prompted investigations into alternative rhBMP-2 carriers that are injectable, settable, and compression-resistant. In this pilot study, we investigated injectable low-viscosity (LV) polymer/composite bone grafts as compression-resistant carriers for rhBMP-2 in a single-level rabbit PLF model...
July 11, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28670415/outcomes-of-revision-surgery-following-instrumented-posterolateral-fusion-in-degenerative-lumbar-spinal-stenosis-a-comparative-analysis-between-pseudarthrosis-and-adjacent-segment-disease
#7
Seung-Pyo Suh, Young-Hoon Jo, Hae Won Jeong, Won Rak Choi, Chang-Nam Kang
STUDY DESIGN: Retrospective study. PURPOSE: We examined the clinical and radiological outcomes of patients who received revision surgery for pseudarthrosis or adjacent segment disease (ASD) following decompression and instrumented posterolateral fusion (PLF). OVERVIEW OF LITERATURE: At present, information regarding the outcomes of revision surgery for complications such as pseudarthrosis and ASD following instrumented PLF is limited. METHODS: This study examined 60 patients who received PLF for degenerative lumbar spinal stenosis and subsequently developed pseudarthrosis or ASD leading to revision surgery...
June 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28652196/efficacy-of-e-coli-derived-rhbmp-2-in-posterolateral-lumbar-fusion-an-open-active-controlled-randomized-multicenter-trial
#8
Jae Hwan Cho, Jae Hyup Lee, Jin Sup Yeom, Bong-Soon Chang, Jae Jun Yang, Ki Hyoung Koo, Chang Ju Hwang, Kwang Bok Lee, Ho-Joong Kim, Choon-Ki Lee, Hyoungmin Kim, Kyung-Soo Suk, Woo Dong Nam, Jumi Han
BACKGROUND CONTEXT: The efficacy and safety of recombinant human bone morphogenetic protein-2 as a bone graft substitute in spinal fusion has been widely researched. However, no study of the efficacy and safety of E.coli-derived rhBMP-2 (E.BMP-2) with a hydroxyapatite (HA) carrier has been proposed. PURPOSE: To compare the efficacy and safety of fusion materials between E.BMP-2 and autogenous iliac bone graft in posterolateral fusion (PLF). STUDY DESIGN/SETTING: Open, active-controlled, randomized, multicenter trial PATIENT SAMPLE: This study included 93 patients who underwent single-level lumbar or lumbosacral PLF...
June 23, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28622184/does-age-influence-the-efficacy-of-demineralized-bone-matrix-enriched-with-concentrated-bone-marrow-aspirate-in-lumbar-fusions
#9
Remi M Ajiboye, Mark A Eckardt, Jason T Hamamoto, Akshay Sharma, Adam Z Khan, Jeffrey C Wang
STUDY DESIGN: Retrospective study. OBJECTIVE: Evaluate the effect of age on the efficacy of allograft/demineralized bone matrix (DBM) enriched with concentrated bone marrow aspirate (BMA) in posterolateral lumbar fusions (PLFs). SUMMARY OF BACKGROUND DATA: Cell-based therapies such as concentrated BMA have been developed as a potential alternative to iliac crest bone graft (ICBG). BMA contains mesenchymal stem cells (MSCs) and growth factors that can confer osteogenic and osteoinductive potential to osteoconductive scaffolds such as DBM/allograft...
June 15, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28585094/a-retrospective-review-comparing-two-year-patient-reported-outcomes-costs-and-healthcare-resource-utilization-for-tlif-vs-plf-for-single-level-degenerative-spondylolisthesis
#10
Elliott Kim, Silky Chotai, David Stonko, Joseph Wick, Alex Sielatycki, Clinton J Devin
PURPOSE: The purpose of this study was to compare patient-reported outcomes (PROs), morbidity, and costs of TLIF vs PLF to determine whether one treatment was superior in the setting of single-level degenerative spondylolisthesis. METHODS: Patients undergoing TLIF or PLF for single-level spondylolisthesis were included for retrospective analysis. EQ-5D, ODI, SF-12 MCS/PCS, NRS-BP/LP scores were collected at baseline and 24 months after surgery. 90-day post-operative complications, revision surgery rates, and satisfaction scores were also collected...
June 5, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28578164/discriminative-ability-of-commonly-used-indices-to-predict-adverse-outcomes-after-poster-lumbar-fusion-a-comparison-of-demographics-asa-the-modified-charlson-comorbidity-index-and-the-modified-frailty-index
#11
Nathaniel T Ondeck, Daniel D Bohl, Patawut Bovonratwet, Ryan P McLynn, Jonathan J Cui, Blake N Shultz, Adam M Lukasiewicz, Jonathan N Grauer
BACKGROUND CONTEXT: As research tools, the American Society of Anesthesiologist physical classification system (ASA), the modified Charlson Comorbidity Index (mCCI), and the modified Frailty Index (mFI) have been associated with complications following spine procedures. However, with respect to clinical utility for various adverse outcomes, no known study has compared the predictive performance of these indices specifically following posterior lumbar fusion (PLF). PURPOSE: To compare the discriminative ability of ASA, mCCI, and mFI as well as demographic factors including age, body mass index (BMI) and gender for perioperative adverse outcomes following PLF...
May 31, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28547574/effect-of-oxy133-an-osteogenic-oxysterol-on-new-bone-formation-in-rat-two-level-posterolateral-fusion-model
#12
Zorica Buser, Susan Drapeau, Frank Stappenbeck, Renata C Pereira, Farhad Parhami, Jeffrey C Wang
PURPOSE: The aim of our study was to determine the effect of Oxy133 and rhBMP2 on fusion rates and new bone formation in a rat posterolateral fusion (PLF) model. Furthermore, we examined whether Oxy133 could inhibit the adipogenesis that is often present in rhBMP2-induced fusions. METHODS: Sixty-four male Lewis rats underwent two levels PLF (L3-L5). All animals were randomly divided into eight groups based on the test compound that they received: control (DMSO), low-dose rhBMP2 (0...
May 25, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28528156/prognostic-impact-of-low-flow-severe-aortic-stenosis-in-small-body-patients-undergoing-tavr-the-ocean-tavi-registry
#13
Akihisa Kataoka, Yusuke Watanabe, Ken Kozuma, Yugo Nara, Fukuko Nagura, Hideyuki Kawashima, Hirofumi Hioki, Makoto Nakashima, Masanori Yamamoto, Kensuke Takagi, Motoharu Araki, Norio Tada, Shinichi Shirai, Futoshi Yamanaka, Kentaro Hayashida
OBJECTIVES: This study aimed to analyze the prognostic impact of low-flow (LF) severe aortic stenosis in small-body patients undergoing transcatheter aortic valve replacement (TAVR). BACKGROUND: Western literature demonstrates a poor prognosis with paradoxical LF and low-flow low-gradient (LF-LG) severe aortic stenosis (AS), as defined by stroke volume index (SVi) <35 ml/m(2) and mean pressure gradient <40 mm Hg with preserved left ventricular ejection fraction (LVEF)...
May 11, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28510795/liver-stiffness-assessed-by-shear-wave-elastography-predicts-postoperative-liver-failure-in-patients-with-hepatocellular-carcinoma
#14
Yinghao Shen, Chenhao Zhou, Guodong Zhu, Guoming Shi, Xiaodong Zhu, Cheng Huang, Jian Zhou, Jia Fan, Hong Ding, Ning Ren, Hui-Chuan Sun
BACKGROUND: Cirrhosis increases a patient's risk of developing postoperative liver failure (PLF). Liver stiffness (LS), assessed by two-dimensional shear wave elastography (SWE), indicates liver fibrosis with high accuracy. Whether LS is superior to portal hypertension (PHT) in predicting PLF remains to be studied. METHODS: The study enrolled 280 patients who underwent hepatectomy for hepatocellular carcinoma from July 2015 to July 2016. All patients received preoperative assessments for LS, PHT, and serum markers of liver fibrosis in addition to other clinicopathological tests...
May 16, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28501409/effect-of-different-fat-supplements-on-performance-of-dairy-calves-during-cold-season
#15
E Ghasemi, M Azad-Shahraki, M Khorvash
The objective of this experiment was to evaluate the effects of starter supplementation with fat sources differing in their fatty acid (FA) profile on performance of dairy calves during cold season. Sixty Holstein calves (3 d of age; 39.7 ± 3.8 kg of body weight) were randomly assigned to 1 of 5 starter diets supplemented with (1) no fat or oil source (control), (2) 3% palm fat (PLF), (3) 3% soybean oil (SBO), (4) 3% tallow (TAL), and (5) a 3.2% mixture (MIX) of PLF, SBO, and fish oil. The fat supplements were substituted for corn in the basal starter diet...
July 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28462903/long-term-outcomes-after-tavi-in-patients-with-different-types-of-aortic-stenosis-the-conundrum-of-low-flow-low-gradient-and-low-ejection-fraction
#16
Miriam Puls, Kerstin Pia Korte, Annalen Bleckmann, Mark Huenlich, Bernhard C Danner, Friedrich Schoendube, Gerd Hasenfuß, Claudius Jacobshagen, Wolfgang Schillinger
AIMS: The objective of this study was to examine the impact of guideline-defined subtypes of severe aortic stenosis (AS) on long-term outcomes after TAVI. METHODS AND RESULTS: Four hundred (400) consecutive patients who underwent TAVI (203 transapical, 197 transfemoral) at our institution 8/2008-3/2013 were followed systematically (for up to seven years). One hundred and forty-seven (147) individuals suffered from NEF-HG AS (LV-EF ≥50%, high Pmean ≥40 mmHg), 63 from LEF-HG AS (LV-EF <50%, high gradient), 77 from PLF-LG AS (LV-EF ≥50%, low gradient, stroke volume index [SVI] <35 ml/m²), and 81 from LEF-LG AS (LV-EF <50%, low gradient)...
June 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28443524/risk-factors-for-prelacteal-feeding-in-sub-saharan-africa-a-multilevel-analysis-of-population-data-from-twenty-two-countries
#17
Anselm S Berde, Hilal Ozcebe
OBJECTIVE: To examine the risk factors of prelacteal feeding (PLF) among mothers in sub-Saharan Africa (SSA). DESIGN: We pooled data from Demographic and Health Surveys in twenty-two SSA countries. The key outcome variable was PLF. A multilevel logistic regression model was used to explore factors associated with PLF. SETTING: Demographic and Health Surveys in twenty-two SSA countries. SUBJECTS: Mother-baby pairs (n 95348)...
August 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28443172/does-discontinuing-teriparatide-treatment-and-replacing-it-with-bisphosphonate-maintain-the-volume-of-the-bone-fusion-mass-after-lumbar-posterolateral-fusion-in-women-with-postmenopausal-osteoporosis
#18
Seiji Ohtori, Sumihisa Orita, Kazuyo Yamauchi, Yawara Eguchi, Yasuchika Aoki, Junichi Nakamura, Miyako Suzuki, Gou Kubota, Kazuhide Inage, Yasuhiro Shiga, Koki Abe, Kazuki Fujimoto, Hirohito Kanamoto, Masahiro Inoue, Hideyuki Kinoshita, Takeo Furuya, Masao Koda
STUDY DESIGN: Retrospective case series. PURPOSE: The purpose of this study was to determine whether discontinuing teriparatide treatment and replacing it with bisphosphonate treatment maintains the volume of the fusion mass after posterolateral fusion (PLF) in women with postmenopausal osteoporosis. OVERVIEW OF LITERATURE: Clinical data support the efficacy of parathyroid hormone (PTH) for lumbar PLF. However, the use of PTH is limited to 2 years...
April 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28435925/distal-junctional-failure-secondary-to-l5-vertebral-fracture-a-report-of-two-rare-cases
#19
Jiong Hao Tan, Kimberly-Anne Tan, Hwee Weng Dennis Hey, Hee-Kit Wong
Distal junctional failure (DJF) with fracture at the last instrumented vertebra is a rare occurrence. In this case report, we present two patients with L5 vertebral fracture post-instrumented fusion of the lumbar spine. The first patient is a 78-year-old female who had multi-level degenerative disc disease, spinal stenosis and degenerative scoliosis involving levels T12 to L5. She underwent instrumented posterolateral fusion (PLF) from T12 to L5, and transforaminal lumbar interbody fusion (TLIF) at L2/3 and L4/5...
March 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/28428063/percutaneous-endoscopical-transforaminal-approach-versus-plf-to-treat-the-single-level-adjacent-segment-disease-after-plf-plif-1-2-years-follow-up
#20
Zhaoyu Ba, Fumin Pan, Zhonghan Liu, Bin Yu, Laurel Fuentes, Desheng Wu, Jianguang Zhu
BACKGROUND: Adjacent segment disease (ASD) is a common complication after lumbar decompression and fusion surgery. Traditional revision-surgery, including posterior lumbar decompression and posterolateral fusion (PLF) or interbody fusion (PLIF) is traumatic. The percutaneous endoscopic transforaminal procedure (PE-TF) has been widely used in patients with lumbar disc disease. However, there are no reports about using PE-TF procedure to treat ASD in the current literature. OBJECTIVE: To compare the clinical outcomes between PE-TF and PLF for single-level ASD after PLF or PLIF...
June 2017: International Journal of Surgery
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