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JOURNAL ARTICLE
Anne-Kathrin Dathe, Sandra Greve, Uta Teschler, Katharina M Heuser-Spura, Larissa Cordier, Bilge Albayrak, Ursula Felderhoff-Mueser, Britta M Huening
Introduction: Structured and standardized follow-up care for preterm and high-risk infants enables an early detection of developmental deficits. The aim is to adapt the in-person follow-up to video consultation. Developmental delays can thus be identified at an early stage, independently of in-person contact. Methods: The adaptation of these follow-up to video consultation is presented descriptively, compared with the in-person consultation (similarities, differences, challenges, and limitations). Professionals's experiences with the adaption are described...
March 12, 2024: Telemedicine Journal and E-health
#22
Gregory W Kirschen, Lucy Brown, Joy Davis, Dan Kim, David J Berman, Timour Al-Khindi, Justin Caplan, Shannon M Osborne
Cerebral aneurysms are rarely encountered in pregnancy. Their antepartum and intrapartum management remain clinically challenging, primarily due to concern regarding potential rupture. We present a case of a patient in preterm labor at risk for imminent delivery with a 10mm cerebral aneurysm. She was recommended for cesarean section (CS), yet delivered via spontaneous vaginal delivery in the operating room after induction of general anesthesia for the intended CS. Her aneurysm and neurologic function remained intact postpartum...
February 2024: Curēus
#23
JOURNAL ARTICLE
Zi-Ming Wang, Jia-Yu Zhou, Wan Tang, Ying-Ying Jiang, Rui Wang, Lai-Shuan Wang
BACKGROUND: The pathophysiology and the potential risks of placental transfusion (PT) differ substantially in preterm infants, necessitating specific studies in this population. This study aimed to evaluate the safety and efficacy of PT in preterm infants from the perspective of long-term neurodevelopmental outcomes. METHODS: We conducted a systematic literature search using placental transfusion, preterm infant, and its synonyms as search terms. Cochrane Central Register of Controlled Trials, Medline, and Embase were searched until March 07, 2023...
February 1, 2024: Pediatric Neurology
#24
JOURNAL ARTICLE
Ursula Kiechl-Kohlendorfer, Burkhard Simma, Angelika Berger, Berndt Urlesberger, Martin Wald, Nadja Haiden, Renate Fuiko, Jean-Pierre Ndayisaba
AIM: The current study determined the neurodevelopmental outcome of extremely preterm infants at 2 years of age. METHODS: All live-born infants 23-27 weeks of gestation born between 2011 and 2020 in Austria were included in a prospective registry. Neurodevelopmental outcome at 2 years of corrected age was assessed using Bayley Scales of Infant Development for both motor and cognitive scores, along with a neurological examination and an assessment of neurosensory function...
March 3, 2024: Acta Paediatrica
#25
REVIEW
Giovanni Boscarino, Viviana Cardilli, Maria Giulia Conti, Federica Liguori, Paola Repole, Pasquale Parisi, Gianluca Terrin
INTRODUCTION: Prolonged mechanical ventilation, commonly used to assist preterm newborns, increases the risk of developing bronchopulmonary dysplasia (BPD). In recent decades, studies have demonstrated that systemic corticosteroids play a significant role in the prevention and management of BPD. In this systematic review of randomized controlled trials (RCTs), we evaluated the association between the administration of systemic corticosteroids in preterm infants and its long-term outcomes, such as neurodevelopment, growth, extubation rate, and related adverse effects...
2024: Frontiers in Pediatrics
#26
JOURNAL ARTICLE
Weibin Ji, Guanya Li, Yang Hu, Wenchao Zhang, Jia Wang, Fukun Jiang, Yaqi Zhang, Feifei Wu, Xiaorong Wei, Yuefeng Li, Xinbo Gao, Peter Manza, Nora D Volkow, Gene-Jack Wang, Yi Zhang
BACKGROUND: Preterm infants with low birthweight are at heightened risk of developmental sequelae, including neurological and cognitive dysfunction that can persist into adolescence or adulthood. In addition, preterm birth and low birthweight can provoke changes in endocrine and metabolic processes that likely impact brain health throughout development. However, few studies have examined associations among birthweight, pubertal endocrine process, long-term neurological and cognitive development...
February 26, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
#27
JOURNAL ARTICLE
Sicong Peng, Xianjing He, Shiwen Xia
INTRODUCTION: Extremely preterm infants (EPIs) have high morbidity and mortality, and are recommended to be born in a tertiary perinatal center (inborn). However, many EPIs in central China are born in lower-level hospitals and transferred postnatally, the outcomes of which remain to be investigated. METHODS: EPIs admitted to the Department of Neonatology, Maternal and Child Health Hospital of Hubei Province from January 2013 to December 2022 were retrospectively recruited and divided into the control (inborn) and transfer groups (born in other hospitals)...
2024: Frontiers in Pediatrics
#28
JOURNAL ARTICLE
Nina Otinashvili, Saba Ahmadi, Luka Iordanishvili, Anashwara Balagopal, Tsotne Gvasalia
Epilepsy is an enduring predisposition of the brain to generate epileptic seizures and has a worldwide incidence of 21-24 per 100,000 cases among children. Epilepsy is a multifactorial disease; however, certain risk factors are predicted to increase its incidence. Abnormal brain development during prenatal life, particularly during the last trimester, is considered to play a crucial role in the development of certain neurological disorders. The present study evaluated a total of 453 children between the ages of 1 to 18 years, with or without epilepsy...
2024: Med Int (Lond)
#29
JOURNAL ARTICLE
Isabelle Guellec, Adelaide Brunet, Alexandre Lapillonne, Marion Taine, Héloïse Torchin, Geraldine Favrais, Géraldine Gascoin, Laure Simon, Barbara Heude, Pauline Scherdel, Gilles Kayem, Pierre Delorme, Pierre-Henri Jarreau, Pierre-Yves Ancel
OBJECTIVE: To determine whether the relative measurement of birth weight (BW) and head circumference (HC) in preterm infants is associated with neurological outcomes. METHODS: The EPIPAGE-2 Study included 3473 infants born before 32 weeks' gestation, classified based on their Z-score of BW and HC on the Fenton curves as concordant (≤1 SD apart) or discordant (>1 SD difference). We defined four mutually exclusive categories: discordant smaller BW (sBW) with BW<HC, discordant smaller HC (sHC) with HC<BW, concordant measurement (CM) with BW and HC concordant and both >-1SD and concordant small measurement (CsM) with BW and HC concordant and both ≤-1SD...
February 26, 2024: Archives of Disease in Childhood
#30
JOURNAL ARTICLE
Ruth M McLeod, Ted S Rosenkrantz, R Holly Fitch
Magnesium sulfate (MagSul) is used clinically to prevent eclamptic seizures during pregnancy and as a tocolytic for preterm labor. More recently, it has been implicated as offering neural protection in utero for at-risk infants. However, evidence is mixed. Some studies found that MagSul reduced the incidence of cerebral palsy (CP) but did not improve other measures of neurologic function. Others did not find any improvement in outcomes. Inconsistencies in the literature may reflect the fact that sex effects are largely ignored, despite evidence that MagSul shows sex effects in animal models of neonatal brain injury...
February 7, 2024: Pharmaceuticals
#31
JOURNAL ARTICLE
Luca Bedetti, Lucia Corso, Francesca Miselli, Isotta Guidotti, Carlotta Toffoli, Rossella Miglio, Maria Federica Roversi, Elisa Della Casa Muttini, Marisa Pugliese, Natascia Bertoncelli, Tommaso Zini, Sofia Mazzotti, Licia Lugli, Laura Lucaccioni, Alberto Berardi
(1) Background: Prematurity is a serious condition associated with long-term neurological disability. This study aimed to compare the neurodevelopmental outcomes of preterm neonates with or without sepsis. (2) Methods: This single-center retrospective case-control study included infants with birth weight < 1500 g and/or gestational age ≤ 30 weeks. Short-term outcomes, brain MRI findings, and severe functional disability (SFD) at age 24 months were compared between infants with culture-proven or culture-negative sepsis or without sepsis...
February 17, 2024: Journal of Clinical Medicine
#32
JOURNAL ARTICLE
Maire Brasseler, Harald Mischak, Joost P Schanstra, Juliane Marie Michel, Lars Pape, Ursula Felderhoff-Müser
INTRODUCTION: Preterm infants are at risk for a variety of somatic and neurological disorders. In recent years, biofluid proteomics has emerged as a potential diagnostic tool for biomarker analysis. The aim of this study was to determine gestational age (GA)-related patterns of the urinary peptidome in preterm infants for researching potential novel prognostic biomarkers. METHODS: We performed urinary peptidomics in longitudinal samples of 24 preterm (mean GA weeks 28 + 1 [24+1-31 + 6]) and 27 term born controls (mean GA weeks 39 + 2 [37+0-41 + 1]) using capillary electrophoresis combined with mass spectrometry (CE-MS)...
February 21, 2024: Neonatology
#33
JOURNAL ARTICLE
Caterina Coviello, Silvia Lori, Giovanna Bertini, Simona Montano, Simonetta Gabbanini, Maria Bastianelli, Cesarina Cossu, Sara Cavaliere, Clara Lunardi, Carlo Dani
OBJECTIVE: The present study aimed to explore first the impact of perinatal risk factors on flash-VEP waves and morphology in a group of preterm infants studied at term equivalent age (TEA). Second, to correlate VEP morphology with neurological outcome at 2 years corrected age (CA). METHODS: Infants with a gestational age (GA) at birth <32 weeks, without major brain injury, were enrolled. Multivariate regression analyses were performed, and the models were run separately for each dependent variable N2, P2, N3 latencies and P2 amplitude...
2024: Clinical Neurophysiology Practice
#34
JOURNAL ARTICLE
Fernando C Barros, Robert B Gunier, Albertina Rego, Loïc Sentilhes, Stephen Rauch, Serena Gandino, Jagjit S Teji, Jim G Thornton, Alisa B Kachikis, Ricardo Nieto, Rachel Craik, Paolo I Cavoretto, Adele Winsey, Paola Roggero, Gabriel B Rodriguez, Valeria Savasi, Erkan Kalafat, Francesca Giuliani, Marta Fabre, Anne Caroline Benski, Irma Alejandra Coronado-Zarco, Stefania Livio, Adela Ostrovska, Nerea Maiz, Fabiola R Castedo Camacho, Ashley Peterson, Philippe Deruelle, Carolina Giudice, Roberto A Casale, Laurent J Salomon, Constanza P Soto Conti, Federico Prefumo, Ehab Zakaria Mohamed Elbayoumy, Marynéa Vale, Valeria Hernández, Katherine Chandler, Milagros Risso, Emily Marler, Daniela M Cáceres, Guadalupe Albornoz Crespo, Ernawati Ernawati, Michal Lipschuetz, Shabina Ariff, Ken Takahashi, Carmen Vecchiarelli, Teresa Hubka, Satoru Ikenoue, Gabriela Tavchioska, Babagana Bako, Adejumoke I Ayede, Brenda Eskenazi, Zulfiqar A Bhutta, Stephen H Kennedy, Aris T Papageorghiou, Jose Villar
BACKGROUND: In early 2023, when Omicron was the variant of concern, we showed that vaccinating pregnant women decreased the risk of severe COVID-19 related complications, and maternal morbidity and mortality. OBJECTIVES: To analyze the impact of COVID-19 during pregnancy on newborns and the effects of maternal COVID-19 vaccination on neonatal outcomes, when Omicron was the variant of concern. STUDY DESIGN: INTERCOVID-2022 is a large, prospective, observational study, conducted in 40 hospitals across 18 countries, from November 27, 2021 (the day after the World Health Organization declared Omicron the variant of concern) to June 30, 2022, to assess the effect of COVID-19 in pregnancy on maternal and neonatal outcomes, as well as vaccine effectiveness (VE)...
February 15, 2024: American Journal of Obstetrics and Gynecology
#35
JOURNAL ARTICLE
Caide Bier, Kaelin Dickey, Brittan Bibb, Angela Crutcher, Rebecca Sponberg, Richard Chang, Monica Boyer, Laura Davis-Keppen, Cindy Matthes, Michelle Tharp, Danielle Vice, Erin Cooney, Megan Morand, Joseph Ray, Melissa Lah, Markey McNutt, Hans C Andersson
BACKGROUND: Adults with PKU have difficulty maintaining plasma phenylalanine (Phe) in the range that is safe for neurologic function. Elevated plasma Phe is a risk factor for congenital anomalies and developmental delay in offspring resulting from pregnancies with poor Phe control in women with PKU. Enzyme supplementation with pegvaliase allows adults with PKU to eat an unrestricted diet and have plasma Phe levels in a safe range for pregnancy but pegvaliase has not been approved for use in pregnant females with PKU...
February 3, 2024: Molecular Genetics and Metabolism
#36
JOURNAL ARTICLE
Yao Cai, Zhirong Deng, Qiuping Yang, Guixian Pan, Zao Liang, Ximei Yang, Jie Song, Xin Xiao, Sitao Li
INTRODUCTION: Pregnancy outcomes of patients with systemic lupus erythematosus (SLE) have improved over the past four decades, leading to an increased desire for pregnancy among this cohort. However, the offspring of patients with SLE still face the risks of preterm birth, low birth weight, learning disabilities, and neurological disorders, while the causes underlying these risks remain unclear. METHODS: In this study, we analyzed the blood metabolic features of neonates born to 30 SLE patients and 52 healthy control mothers by employing tandem mass spectrometry with the dual aims of identifying the etiology of metabolic features specific to infants born from mothers with SLE and providing new insights into the clinical management of such infants...
2024: Frontiers in Immunology
#37
JOURNAL ARTICLE
Elham Manouchehri, Somayeh Makvandi, Mahdieh Razi, Maryam Sahebari, Mona Larki
BACKGROUND: Preterm labor (PTL) is a common and serious pregnancy disorder that can cause long-term neurological issues in the infant. There are conflicting studies concerning whether sildenafil citrate (SC) reduces preterm labor complications. Therefore, the meta-analysis aimed to examine the clinical outcomes in women with threatened PTL who received nifedipine plus SC therapy versus only nifedipine. METHODS: For the original articles, six databases were searched using relevant keywords without restriction on time or language until January 13, 2024...
February 10, 2024: BMC Pediatrics
#38
JOURNAL ARTICLE
Aude Buil, Nelly Thomas, Benoît Chevalier, Emmanuel Devouche
BACKGROUND: Preterm birth is associated with a high risk of long-term neuromotor disabilities such as coordination of movements, deficient antigravity limb movement, less adaptive postural control strategies, head deformities… AIMS: The aim of the present study was to examine the potential positive impact of a Supported Diagonal Flexion (SDF) skin-to-skin contact (SSC) positioning on the neuromotor development and movement quality of very preterm infants at term age. STUDY DESIGN: Monocentric prospective matched-pair case-control study...
February 6, 2024: Early Human Development
#39
JOURNAL ARTICLE
Arne Jensen, Niels Rochow, Manfred Voigt, Gerhard Neuhäuser
BACKGROUND: Fetal growth restriction and immaturity are associated with poor neurocognitive development and child psychopathology affecting educational success at school and beyond. However, the differential effects of either obstetrical risk factor on predicted psychomotor development have not yet been deciphered. OBJECTIVE: This study aimed to separately study the impact of growth restriction and that of immaturity on predicted psychomotor development at the preschool age of 4...
February 2024: AJOG global reports
#40
MULTICENTER STUDY
Xiao-Yu Dong, Jian-Hong Qi, Qing-Cui Zhuo, Yan-Jie Ding, Xin Qiao, Yan Wang, De-Juan Yang, Dan Li, Li Li, Hai-Yan Jiang, Qiong-Yu Liu, Zhong-Liang Li, Xiang Zhang, Bing-Jin Zhang, Yong-Hui Yu
BACKGROUND: Hypertensive disorders of pregnancy (HDP) is the most common cause of indicated preterm delivery, but the impact of prenatal steroid exposure on the outcomes of preterm infants born to HDP mothers, who may be at risk for intrauterine hypoxia-ischemia, remains uncertain. The study objective is to evaluate the mortality and morbidities in HDP for very preterm infants (VPIs) exposed to different course of ANS. METHODS: This is a prospective cohort study comprising infants with < 32 weeks gestation born to women with HDP only from 1 Jan...
February 5, 2024: BMC Pregnancy and Childbirth
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