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Neurological risk preterm

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https://www.readbyqxmd.com/read/28102574/fidgety-movements-in-infants-born-very-preterm-predictive-value-for-cerebral-palsy-in-a-clinical-multicentre-setting
#1
Alexandre N Datta, Mark A Furrer, Iris Bernhardt, Petra S Hüppi, Cristina Borradori-Tolsa, Hans Ulrich Bucher, Beatrice Latal, Sebastian Grunt, Giancarlo Natalucci
AIM: This study assessed predictive values of fidgety movement assessment (FMA) in a large sample of infants born very preterm for developmental abnormalities, in particular for cerebral palsy (CP) at 2 years in an everyday clinical setting. METHOD: This is a multicentre study of infants born preterm with gestational age lower than 32.0 weeks. FMA was performed at 3 months corrected age; neurodevelopment (Bayley Scales of Infant Development, 2nd edition) and neurological abnormalities were assessed at 2 years...
January 19, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28079875/early-postnatal-illness-severity-scores-predict-neurodevelopmental-impairments-at-10-years-of-age-in-children-born-extremely-preterm
#2
J W Logan, O Dammann, E N Allred, C Dammann, K Beam, R M Joseph, T M O'Shea, A Leviton, K C K Kuban
OBJECTIVE: A neonatal illness severity score, The Score for Neonatal Acute Physiology-II (SNAP-II), predicts neurodevelopmental impairments at two years of age among children born extremely preterm. We sought to evaluate to what extent SNAP-II is predictive of cognitive and other neurodevelopmental impairments at 10 years of age. STUDY DESIGN: In a cohort of 874 children born before 28 weeks of gestation, we prospectively collected clinical, physiologic and laboratory data to calculate SNAP-II for each infant...
January 12, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28041866/-management-of-patent-ductus-arteriosus-in-preterm-infants-an-evidence-based-approach
#3
V Gournay
A patent ductus arteriosus, very common in the preterm infant (incidence up to 70% in infants less than 28 weeks gestational age), causes a left-to-right shunt leading to overload of the pulmonary circulation and low systemic blood flow. These hemodynamic anomalies are associated with a higher incidence of respiratory, neurological, and digestive complications of prematurity, as well as a higher mortality rate. Although growing knowledge about the natural history, the pathophysiology, and the mechanisms of closure of the ductus arteriosus has resulted in therapeutic progress, management of the patent ductus arteriosus in the preterm infant is still a subject of intense controversy...
December 29, 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28026756/longitudinal-analysis-of-pre-term-neonatal-cerebral-ventricles-from-3d-ultrasound-images-using-spatial-temporal-deformable-registration
#4
Wu Qiu, Yimin Chen, Jessica Kishimoto, Sandrine Ribaupierre, Bernard Chiu, Aaron Fenster, Bijoy Menon, Jing Yuan
Preterm neonates with a very low birth weight of less than 1,500 grams are at increased risk for developing intraventricular hemorrhage (IVH), which is a major cause of brain injury in preterm neonates. Quantitative measurements of ventricular dilatation or shrinkage play an important role in monitoring patients and evaluating treatment options. 3D ultrasound (US) has been developed to monitor ventricle volume as a biomarker for ventricular changes. However, ventricle volume as a global indicator does not allow for precise analysis of local ventricular changes, which could be linked to specific neurological problems often seen in the patient population later in life...
December 22, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27981252/thyroid-hormone-dysfunction-during-pregnancy-a-review
#5
REVIEW
Aynadis Alemu, Betelihem Terefe, Molla Abebe, Belete Biadgo
Thyroid dysfunctions such as hypothyroidism, thyrotoxicosis and thyroid nodules may develop during pregnancy leading to abortion, placental abruptions, preeclampsia, preterm delivery and reduced intellectual function in the offspring. Epidemiological data have shown the significant role of maternal thyroid hormone in fetal neurologic development and maternal health. It has been suggested that the deleterious effects of thyroid dysfunction can also extend beyond pregnancy and delivery to affect neuro-intellectual development in the early life of the child...
November 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27934841/aeromonas-hydrophila-meningitis-and-fulminant-sepsis-in-preterm-newborn-a-case-report-and-review-of-literature
#6
A Kali, R Kalaivani, Pmv Charles, K S Seetha
Neonatal meningitis is a lethal infection occurring in the 1st month of life. The risk of developing permanent neurological sequels is high among the neonates who survive. Bacterial pathogens are commonly associated with this condition. Aeromonas is a Gram-negative bacteria of aquatic habitat. Although isolation of Aeromonas species from neonates with blood stream infection is infrequently reported, neonatal meningitis caused by Aeromonas is exceedingly rare. We present a case of fulminant sepsis and meningitis caused by Aeromonas hydrophila in a preterm newborn male...
October 2016: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27922237/the-comparison-of-general-movements-assessment-and-neurological-examination-during-early-infancy
#7
Büşra Kepenek-Varol, Mine Çalışkan, Zeynep İnce, Burak Tatlı, Emine Eraslan, Asuman Çoban
This prospective single-blinded study was performed to evaluate general movements (GMs) in group of high-risk, low-birth-weight and preterm infants and to compare results with neurologic examination. All infants' neurologic examinations, Gross Motor Function Measurement (GMFM) and Bayley-III Scale were performed at the corrected age of 12 months. A total of 22 infants were included. Eight infants (group-1) (mean: 31.6±3.29 weeks, range: 25-36 weeks) had normal GMs in all recordings and were ultimately evaluated as "normal"; 12 (group-2) (mean: 31...
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27892813/thinking-about-social-and-nonsocial-alternative-possibilities-in-premature-preschoolers
#8
María Dolores Roldán-Tapia, Sergio Moreno-Ríos, Rosa Cánovas-López
INTRODUCTION: Prematurely born preschoolers show developmental cognitive delay compared to full-term children. There are important neurological networks developing at preschool age related to perspective taking about the attribution of belief and to deduction with contrary-to-fact situations. Other deductive abilities may be completed during that period. METHOD: A group of very prematurely born children (N = 35) aged between 4 and 5 years was compared with a control group of children born at full term (N = 35)...
November 28, 2016: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/27885286/immediate-outcome-of-hypoxic-ischaemic-encephalopathy-in-hypoxiate-newborns-in-nepal-medical-college
#9
S Shrestha, G S Shrestha, A Sharma
BACKGROUND: Birth asphyxia is the fifth major cause of under-five child deaths after pneumonia, diarrhoea, neonatal infections and complications of preterm birth. It is one of the important causes of neonatal mortality and morbidity accounting up to 30% of neonatal death in Nepal. It is also an important cause of long-term neurological disability and impairment. The mortality rate due to birth asphyxia is considered a good guide to the quality of perinatal care. This study was conducted to assess the rate of birth asphyxia, risk factors and outcome of the babies who were asphyxiated at birth...
May 2016: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/27812521/preterm-hypoxic-ischemic-encephalopathy
#10
REVIEW
Krishna Revanna Gopagondanahalli, Jingang Li, Michael C Fahey, Rod W Hunt, Graham Jenkin, Suzanne L Miller, Atul Malhotra
Hypoxic-ischemic encephalopathy (HIE) is a recognizable and defined clinical syndrome in term infants that results from a severe or prolonged hypoxic-ischemic episode before or during birth. However, in the preterm infant, defining hypoxic-ischemic injury (HII), its clinical course, monitoring, and outcomes remains complex. Few studies examine preterm HIE, and these are heterogeneous, with variable inclusion criteria and outcomes reported. We examine the available evidence that implies that the incidence of hypoxic-ischemic insult in preterm infants is probably higher than recognized and follows a more complex clinical course, with higher rates of adverse neurological outcomes, compared to term infants...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27776846/-prevention-of-preterm-birth-complications-by-antenatal-corticosteroid-administration
#11
T Schmitz
OBJECTIVE: To evaluate short- and long-term benefits and risks associated with antenatal administration of a single course of corticosteroids and the related strategies: multiple and rescue courses. METHODS: The PubMed database, the Cochrane Library and the recommendations from the French and foreign obstetrical societies or colleges have been consulted. RESULTS: Antenatal administration of a single course of corticosteroids before 34 weeks of gestation is associated in the neonatal period with a significant reduction of respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH), necrotizing enterocolitis (NEC) and death (LE1), and in possibly childhood with a reduction of cerebral palsy and increased psychomotor development index and intact survival (LE3)...
December 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/27757087/impact-of-cerebral-visual-impairments-on-motor-skills-implications-for-developmental-coordination-disorders
#12
Sylvie Chokron, Gordon N Dutton
Cerebral visual impairment (CVI) has become the primary cause of visual impairment and blindness in children in industrialized countries. Its prevalence has increased sharply, due to increased survival rates of children who sustain severe neurological conditions during the perinatal period. Improved diagnosis has probably contributed to this increase. As in adults, the nature and severity of CVI in children relate to the cause, location and extent of damage to the brain. In the present paper, we define CVI and how this impacts on visual function...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27755130/twin-pregnancy-complicated-by-selective-growth-restriction
#13
Rosemary Townsend, Asma Khalil
PURPOSE OF REVIEW: Selective intrauterine growth restriction (sIUGR) in twin pregnancies presents a complex management problem for the fetal medicine specialist. This review summarizes what is currently known about sIUGR pathophysiology, particularly in monochorionic pregnancies and looks at the results of early trials of fetal intervention in high-risk sIUGR pregnancies. RECENT FINDINGS: sIUGR in monochorionic pregnancies is due to unequal placental sharing, but the clinical outcome is determined by the characteristics of the placental vascular anastomoses...
December 2016: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27661654/practice-bulletin-no-171-management-of-preterm-labor
#14
(no author information available yet)
Preterm birth is the leading cause of neonatal mortality and the most common reason for antenatal hospitalization . In the United States, approximately 12% of all live births occur before term, and preterm labor preceded approximately 50% of these preterm births . Although the causes of preterm labor are not well understood, the burden of preterm births is clear-preterm births account for approximately 70% of neonatal deaths and 36% of infant deaths as well as 25-50% of cases of long-term neurologic impairment in children ...
2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27661646/practice-bulletin-no-171-summary-management-of-preterm-labor
#15
(no author information available yet)
Preterm birth is the leading cause of neonatal mortality and the most common reason for antenatal hospitalization (1-4). In the United States, approximately 12% of all live births occur before term, and preterm labor preceded approximately 50% of these preterm births (5, 6). Although the causes of preterm labor are not well understood, the burden of preterm births is clear-preterm births account for approximately 70% of neonatal deaths and 36% of infant deaths as well as 25-50% of cases of long-term neurologic impairment in children (7-9)...
October 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27606053/perinatal-neuroprotection-update
#16
REVIEW
Angie C Jelin, Kirsten Salmeen, Dawn Gano, Irina Burd, Mari-Paule Thiet
Antepartum, intrapartum, and neonatal events can result in a spectrum of long-term neurological sequelae, including cerebral palsy, cognitive delay, schizophrenia, and autism spectrum disorders [1]. Advances in obstetrical and neonatal care have led to survival at earlier gestational ages and consequently increasing numbers of periviable infants who are at significant risk for long-term neurological deficits. Therefore, efforts to decrease and prevent cerebral insults attempt not only to decrease preterm delivery but also to improve neurological outcomes in infants delivered preterm...
2016: F1000Research
https://www.readbyqxmd.com/read/27535894/endothelin-receptor-antagonists-for-persistent-pulmonary-hypertension-in-term-and-late-preterm-infants
#17
REVIEW
Kiran More, Gayatri K Athalye-Jape, Shripada C Rao, Sanjay K Patole
BACKGROUND: Endothelin, a powerful vasoconstrictor, is one of the mediators in the causation of persistent pulmonary hypertension of the newborn (PPHN). Theoretically, endothelin receptor antagonists (ETRA) have the potential to improve the outcomes of infants with PPHN. OBJECTIVES: To assess the efficacy and safety of ETRA in the treatment of PPHN in full-term, post-term and late preterm infants.To assess the efficacy and safety of selective ETRAs (which block only the ETA receptors) and non-selective ETRAs (which block both ETA and ETB receptors) separately...
August 18, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27522216/evidence-on-adrenaline-use-in-resuscitation-and-its-relevance-to-newborn-infants-a-non-systematic-review
#18
Merlin Pinto, Anne Lee Solevåg, Megan OʼReilly, Khalid Aziz, Po-Yin Cheung, Georg M Schmölzer
AIM: Guidelines for newborn resuscitation state that if the heart rate does not increase despite adequate ventilation and chest compressions, adrenaline administration should be considered. However, controversy exists around the safety and effectiveness of adrenaline in newborn resuscitation. The aim of this review was to summarise a selection of the current knowledge about adrenaline during resuscitation and evaluate its relevance to newborn infants. METHODS: A search in PubMed, Embase, and Google Scholar until September 1, 2015, using search terms including adrenaline/epinephrine, cardiopulmonary resuscitation, death, severe brain injury, necrotizing enterocolitis, bronchopulmonary dysplasia, and adrenaline versus vasopressin/placebo...
2017: Neonatology
https://www.readbyqxmd.com/read/27520849/impact-of-fetal-growth-restriction-on-neurodevelopmental-outcome-at-2%C3%A2-years-for-extremely-preterm-infants-a-single-institution-study
#19
Mayass El Ayoubi, Juliana Patkai, Cécile Bordarier, Luc Desfrere, Guy Moriette, Pierre-Henri Jarreau, Jennifer Zeitlin
AIM: We evaluated the impact of fetal growth restriction on neurodevelopmental outcomes at 2 years corrected age for infants born before 27 weeks gestational age. METHOD: Data on infants born before 27 weeks gestational age between 1999 and 2008 (n=463), admitted to a tertiary neonatal unit in Paris, were used to compare neurological outcomes at 2 years for infants with birthweight lower than the 10th centile and birthweight of at least the 10th centile, using intrauterine reference curves...
December 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27513713/minor-neurological-dysfunction-in-five-year-old-very-preterm-children-is-associated-with-lower-processing-speed
#20
Tinka Kurpershoek, Eva S Potharst-Sirag, Cornelieke S H Aarnoudse-Moens, Aleid G van Wassenaer-Leemhuis
BACKGROUND: Minor neurological dysfunction (MND) is present in one quarter to one third of children born very preterm (VP). The more severe form, complex (c)-MND has been associated with learning disabilities, behavioural and motor problems. OBJECTIVE: To study the association between c-MND and neurocognitive and motor disabilities at age five in VP children without CP. METHODS: Ninety-four children born with gestational age<30weeks and/or a birth weight<1000g were assessed at five years corrected age...
December 2016: Early Human Development
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