Youssouf Sereme, Cécile Schrimp, Helène Faury, Maeva Agapoff, Esther Lefebvre-Wloszczowski, Yunhua Chang Marchand, Elisabeth Ageron-Ardila, Emilie Panafieu, Frank Blec, Mathieu Coureuil, Eric Frapy, Vassilis Tsatsaris, Stephane Bonacorsi, David Skurnik
Preterm birth is currently the leading cause of neonatal morbidity and mortality. Genetic, immunological and infectious causes are suspected. Preterm infants have a higher risk of severe bacterial neonatal infections, most of which are caused by Escherichia coli an in particular E. coli K1strains. Women with history of preterm delivery have a high risk of recurrence and therefore constitute a target population for the development of vaccine against E. coli neonatal infections. Here, we characterize the immunological, microbiological and protective properties of a live attenuated vaccine candidate in adult female mice and their pups against after a challenge by K1 and non-K1 strains of E...
April 8, 2024: Nature Communications