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https://www.readbyqxmd.com/read/29898689/obstetric-outcomes-and-effects-on-babies-born-to-women-treated-for-epilepsy-during-pregnancy-in-a-resource-limited-setting-a-comparative-cohort-study
#1
Priyadarshani Galappatthy, Chiranthi Kongala Liyanage, Marianne Nishani Lucas, Dilini T L M Jayasekara, Sachith Aloka Abhayaratna, Chamari Weeraratne, Kusum De Abrew, Padma Sriyani Gunaratne, Ranjani Gamage, Chandrika N Wijeyaratne
BACKGROUND: Management of epilepsy during pregnancy in a resource-limited setting (RLS) is challenging. This study aimed to assess obstetric outcomes and effects on babies of women with epilepsy (WWE) exposed to Anti-epileptic drugs (AEDs) compared to non-exposed controls in a RLS. METHODS: Pregnant WWE were recruited from antenatal and neurology clinics of a tertiary care hospitals in Sri Lanka. Patients were reviewed in each trimester and post-partum. Medication adherence, adverse effects, seizure control and carbamazepine blood levels were monitored...
June 14, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29876249/early-prediction-of-cognitive-deficits-in-very-preterm-infants-using-functional-connectome-data-in-an-artificial-neural-network-framework
#2
Lili He, Hailong Li, Scott K Holland, Weihong Yuan, Mekibib Altaye, Nehal A Parikh
Investigation of the brain's functional connectome can improve our understanding of how an individual brain's organizational changes influence cognitive function and could result in improved individual risk stratification. Brain connectome studies in adults and older children have shown that abnormal network properties may be useful as discriminative features and have exploited machine learning models for early diagnosis in a variety of neurological conditions. However, analogous studies in neonates are rare and with limited significant findings...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29847833/in-preterm-infants-length-growth-below-expected-growth-during-hospital-stay-predicts-poor-neurodevelopment-at-2-years
#3
Laure Simon, Camille Théveniaut, Cyril Flamant, Anne Frondas-Chauty, Dominique Darmaun, Jean-Christophe Rozé
BACKGROUND: In preterm infants, neonatal weight growth is associated with neurodevelopmental outcome but is a poor indicator of growth quality. OBJECTIVE: The aim of this work was to measure the relationship between neonatal length growth and the 2-year neurological outcome in preterm infants. METHODS: A total of 2,403 infants enrolled in the LIFT cohort with gestational age less than 34 weeks were studied. Neonatal observed length growth (OLG) was calculated as the change in length Z-score between birth and discharge...
May 30, 2018: Neonatology
https://www.readbyqxmd.com/read/29846198/innovations-and-challenges-of-implementing-a-glucose-gel-toolkit-for-neonatal-hypoglycemia
#4
Denise Hammer, Carla Pohl, Peggy J Jacobs, Susan Kaufman, Brenda Drury
BACKGROUND: Transient neonatal hypoglycemia occurs most commonly in newborns who are small for gestational age, large for gestational age, infants of diabetic mothers, and late preterm infants. An exact blood glucose value has not been determined for neonatal hypoglycemia, and it is important to note that poor neurologic outcomes can occur if hypoglycemia is left untreated. Interventions that separate mothers and newborns, as well as use of formula to treat hypoglycemia, have the potential to disrupt exclusive breastfeeding...
May 24, 2018: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/29843263/successful-exchange-transfusion-in-extremely-preterm-infant-after-symptomatic-lipid-overdose
#5
M J Rodríguez-Castaño, B Iglesias, L Arruza
BACKGROUND: Complications of intravenous lipid administration are relatively uncommon. However, inadvertent rapid infusion of intravenous fat emulsion (IVFE) is an inherent risk when fats are infused separately from the dextrose-amino acid solution. CASE REPORT: Extremely preterm infant, born at 25 weeks and 6 days of gestational age weighing 920 g, who inadvertently received a massive overdose of IVFE due to a device failure. He developed lethargy, apnea, metabolic acidosis and hemodynamic instability requiring mechanical ventilation and inotropic support...
May 23, 2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29773664/cognitive-development-and-quality-of-life-associated-with-bpd-in-10-year-olds-born-preterm
#6
Sudhir Sriram, Michael D Schreiber, Michael E Msall, Karl C K Kuban, Robert M Joseph, T Michael O' Shea, Elizabeth N Allred, Alan Leviton
OBJECTIVES: To compare neurocognitive, language, executive function, academic achievement, neurologic and behavioral outcomes, and quality of life at age 10 years in children born extremely preterm who developed bronchopulmonary dysplasia (BPD) to children who did not develop BPD. METHODS: The Extremely Low Gestational Age Newborns study population included 863 children born extremely preterm whose BPD status before discharge was known had an IQ (Differential Ability Scales II [DAS II]) assessment at 10 years...
May 17, 2018: Pediatrics
https://www.readbyqxmd.com/read/29765787/liver-failure-and-conjugated-hyperbilirubinemia-in-a-preterm-neonate-role-of-early-ivig-and-exchange-transfusion
#7
Jayasree Nair, Vasantha H S Kumar
Neonatal liver failure (NLF) is a rare diagnosis but carries with it significant risks of mortality and morbidity. Common etiologies for NLF include metabolic causes, gestational alloimmune liver disease (GALD or neonatal hemochromatosis), and viral infections. We report a case of liver failure in a premature infant with abnormal iron profile within 48 hours of birth. Lack of accepted guidelines for the initial management of severe jaundice with a high direct component in the first week after birth made treatment challenging...
April 2018: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/29763893/patterns-of-infancy-growth-and-metabolic-hormonal-profile-are-different-in-very-low-birth-weight-preterm-infants-born-small-for-gestational-age-compared-to-those-born-appropriate-for-gestational-age
#8
María Isabel Hernandez, Katherine Rossel, Veronica Peña, Mirna Garcia, Gabriel Cavada, Alejandra Avila, German Iñiguez, Verónica Mericq
BACKGROUND/AIMS: An increased preterm birth survival rate is associated with long-term neurological and metabolic risks; thus, our aim was to evaluate whether early patterns of infancy anthropometry and metabolic hormonal profile differ in preterm infants born small for gestational age (SGA) or appropriate for gestational age (AGA) from birth to 36 months of corrected age (CA). METHODS: We recruited 110 very-low-birth-weight (VLBW) preterm infants (AGA = 60 and SGA = 50) with a mean birth weight of -2...
May 15, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29755962/acceptability-of-bedside-resuscitation-with-intact-umbilical-cord-to-clinicians-and-patients-families-in-the-united-states
#9
Anup C Katheria, Samuel R Sorkhi, Kasim Hassen, Arij Faksh, Zahra Ghorishi, Debra Poeltler
Background: While delayed umbilical cord clamping in preterm infants has shown to improve long-term neurological outcomes, infants who are thought to need resuscitation do not receive delayed cord clamping even though they may benefit the most. A mobile resuscitation platform allows infants to be resuscitated at the mother's bedside with the cord intact. The newborn is supplied with placental blood during the resuscitation in view of the mother. The objective of the study is to assess the usability and acceptability of mobile resuscitation platform, LifeStart trolley, among the infants' parents and perinatal providers...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29726792/early-surgical-management-and-long-term-surgical-outcome-for-intraventricular-hemorrhage-related-posthemorrhagic-hydrocephalus-in-shunt-treated-premature-infants
#10
Hans Christoph Bock, Jacqueline Feldmann, Hans Christoph Ludwig
OBJECTIVE Perinatal intraventricular hemorrhage (IVH) in premature neonates may lead to severe neurological disability and lifelong treatment requirement for consecutive posthemorrhagic hydrocephalus (PHHC). Early CSF diversion as a temporizing measure, or a permanent ventriculoperitoneal shunt (VPS), is the treatment of choice. Preterm neonates are not only at high risk for different perinatal but also for treatment-related complications. The authors reviewed their institutional neurosurgical management for preterm neonates with IVH-related PHHC and evaluated shunt-related surgical outcome for this particular hydrocephalus etiology after completion of a defined follow-up period of 5 years after initial shunt insertion...
May 4, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29713307/fetal-neuroprotection-by-magnesium-sulfate-from-translational-research-to-clinical-application
#11
REVIEW
Clément Chollat, Loïc Sentilhes, Stéphane Marret
Despite improvements in perinatal care, preterm birth still occurs regularly and the associated brain injury and adverse neurological outcomes remain a persistent challenge. Antenatal magnesium sulfate administration is an intervention with demonstrated neuroprotective effects for preterm births before 32 weeks of gestation (WG). Owing to its biological properties, including its action as an N -methyl-d-aspartate receptor blocker and its anti-inflammatory effects, magnesium is a good candidate for neuroprotection...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29709428/developmental-outcome-in-a-group-of-twins-relation-to-perinatal-factors-and-general-movements
#12
Tamara Dostanic, Breda Sustersic, Darja Paro-Panjan
BACKGROUND: The quality of general movements (GMs) has proven to have predictive value for the developmental outcome, but this has not yet been studied in twins. AIMS: Our aim was to analyse the quality of GMs and neurological and developmental outcome in relation to the gestational age (GA), mode of conception and other perinatal risk factors in a group of twins. STUDY DESIGN: The documentation of twins referred for follow-up in the period from 1998 to 2016 was studied retrospectively...
April 20, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29679046/impact-of-antenatal-corticosteroids-in-preterm-neonates-based-on-maternal-body-mass-index
#13
Maheer Faden, Sarah D McDonald, Prakeshkumar S Shah, Amit Mukerji
OBJECTIVE: Impact of antenatal corticosteroid (ACS) in context of maternal body mass index (BMI) as it relates to neonatal outcomes remains unclear. We sought to evaluate effects of ACS on clinical outcomes of preterm infants based on maternal BMI. METHODS: We performed a retrospective cohort study among neonates 23-33 weeks' GA at a tertiary neonatal intensive care unit from 2011 to 2015. Outcomes of neonates exposed to any ACS and pre-pregnancy maternal BMI ≥ 25 (N = 491) were compared with maternal BMI < 25 (N = 484)...
April 20, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29673373/chorioamnionitis-neuroinflammation-and-injury-timing-is-key-in-the-preterm-ovine-fetus
#14
Ruth Gussenhoven, Rob J J Westerlaken, Daan R M G Ophelders, Alan H Jobe, Matthew W Kemp, Suhas G Kallapur, Luc J Zimmermann, Per T Sangild, Stanislava Pankratova, Pierre Gressens, Boris W Kramer, Bobbi Fleiss, Tim G A M Wolfs
BACKGROUND: Antenatal infection (i.e., chorioamnionitis) is an important risk factor for adverse neurodevelopmental outcomes after preterm birth. Destructive and developmental disturbances of the white matter are hallmarks of preterm brain injury. Understanding the temporal effects of antenatal infection in relation to the onset of neurological injury is crucial for the development of neurotherapeutics for preterm infants. However, these dynamics remain unstudied. METHODS: Time-mated ewes were intra-amniotically injected with lipopolysaccharide at 5, 12, or 24 h or 2, 4, 8, or 15 days before preterm delivery at 125 days gestational age (term ~ 150 days)...
April 19, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29666163/neurodevelopmental-impairment-among-extremely-preterm-infants-in-the-neonatal-research-network
#15
Ira Adams-Chapman, Roy J Heyne, Sara B DeMauro, Andrea F Duncan, Susan R Hintz, Athina Pappas, Betty R Vohr, Scott A McDonald, Abhik Das, Jamie E Newman, Rosemary D Higgins
OBJECTIVES: Evaluate the spectrum of neurodevelopmental outcome in a contemporary cohort of extremely preterm infants. We hypothesize that the rate of severe neurodevelopmental impairment (NDI) decreases over time. METHODS: Retrospective analysis of neurodevelopmental outcome of preterm infants ≤27 weeks' gestational age (GA) from a Neonatal Research Network center that completed neurodevelopmental follow-up assessments between April 1, 2011, and January 1, 2015...
May 2018: Pediatrics
https://www.readbyqxmd.com/read/29659125/extremely-preterm-children-exhibit-increased-interhemispheric-connectivity-for-language-findings-from-fmri-constrained-meg-analysis
#16
Maria E Barnes-Davis, Stephanie L Merhar, Scott K Holland, Darren S Kadis
Children born extremely preterm are at significant risk for cognitive impairment, including language deficits. The relationship between preterm birth and neurological changes that underlie cognitive deficits is poorly understood. We use a stories-listening task in fMRI and MEG to characterize language network representation and connectivity in children born extremely preterm (n = 15, <28 weeks gestation, ages 4-6 years), and in a group of typically developing control participants (n = 15, term birth, 4-6 years)...
April 16, 2018: Developmental Science
https://www.readbyqxmd.com/read/29656825/parenteral-nutrition-for-preterm-infants-issues-and-strategy
#17
D Darmaun, A Lapillonne, U Simeoni, J-C Picaud, J-C Rozé, E Saliba, A Bocquet, J-P Chouraqui, C Dupont, F Feillet, M-L Frelut, J-P Girardet, D Turck, A Briend
Due to transient gut immaturity, most very preterm infants receive parenteral nutrition (PN) in the first few weeks of life. Yet providing enough protein and energy to sustain optimal growth in such infants remains a challenge. Extrauterine growth restriction is frequently observed in very preterm infants at the time of discharge from hospital, and has been found to be associated with later impaired neurodevelopment. A few recent randomized trials suggest that intensified PN can improve early growth; whether or not such early PN improves long-term neurological outcome is still unclear...
May 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29649028/does-the-incidence-of-postoperative-complications-after-inguinal-hernia-repair-justify-hospital-admission-in-prematurely-and-term-born-infants
#18
Marina Massoud, A Y Rosalie Kühlmann, Monique van Dijk, Lonneke M Staals, Rene M H Wijnen, Joost van Rosmalen, Cornelius E J Sloots, Claudia M G Keyzer-Dekker
BACKGROUND: Postoperatively, young infants are admitted overnight in view of the risk for respiratory complications such as desaturation and apnea. This risk seems much lower than previously reported. Until what age this risk persists, and which infants might actually qualify for day-care treatment, is unknown. METHODS: We retrospectively reviewed medical charts from preterm infants <45 weeks postconceptional age (PCA), 45-60 weeks PCA, and term infants <3 months admitted overnight after inguinal hernia repair, from January 2011 to December 2015 in a large tertiary children's hospital...
April 11, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29624206/paracetamol-acetaminophen-for-patent-ductus-arteriosus-in-preterm-or-low-birth-weight-infants
#19
REVIEW
Arne Ohlsson, Prakeshkumar S Shah
BACKGROUND: In preterm newborns, the ductus arteriosus frequently fails to close and the infants require medical or surgical closure of the patent ductus arteriosus (PDA). A PDA can be treated surgically; or medically with one of two prostaglandin inhibitors, indomethacin or ibuprofen. Case reports suggest that paracetamol may be an alternative for the closure of a PDA. An association between prenatal or postnatal exposure to paracetamol and later development of autism or autism spectrum disorder has been reported...
April 6, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29615483/incidence-of-hypocapnia-hypercapnia-and-acidosis-and-the-associated-risk-of-adverse-events-in-preterm-neonates
#20
Melissa K Brown, Deborah M Poeltler, Kasim O Hassen, Danielle V Lazarus, Vanessa K Brown, Jeremiah J Stout, Wade D Rich, Anup C Katheria
BACKGROUND: Permissive hypercapnia is a lung-protection strategy. We sought to review our current clinical practice for the range of permissive hypercapnia and identify the relationship between P aCO2 and pH and adverse outcomes. METHODS: A secondary analysis of a delayed cord-clamping clinical trial was performed on all arterial blood gas tests in the first 72 h in infants < 32 weeks gestational age. All arterial blood gas values were categorized into a clinical range to determine the percent likelihood of occurring in the total sample...
April 3, 2018: Respiratory Care
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