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Testosterone for women

Richard S Legro, Allen R Kunselman, Christy M Stetter, Carol L Gnatuk, Stephanie J Estes, Eleanor Brindle, Hubert W Vesper, Julianne C Botelho, Peter A Lee, William C Dodson
CONTEXT: Daughters of women with polycystic ovary syndrome (PCOS) are thought to be at increased risk for developing stigmata of the syndrome, but the ontogeny during puberty is uncertain. OBJECTIVE: To phenotype daughters (N = 76) of mothers with PCOS and daughters (N = 80) from control mothers for reproductive and metabolic parameters characteristic of PCOS. DESIGN, SETTING, AND PARTICIPANTS: Matched Case/Control Study, Penn State Hershey Medical Center, Non-Hispanic, Caucasian girls age 4-17 INTERVENTION: Obtain birth history, biometric, ovarian ultrasounds, whole body DXA scan for body composition, 2 hour glucose challenged salivary insulin levels and two timed urinary collections (12 hours overnight and 3 hours AM) for gonadotropins and sex steroids...
October 25, 2016: Journal of Clinical Endocrinology and Metabolism
Amelia Guadalupe-Grau, Jose Antonio Carnicero, Jose Losa-Reyna, Jesús Tresguerres, Maria Del Carmen Gómez-Cabrera, Carmen Castillo, Ana Alfaro-Acha, Cristina Rosado-Artalejo, Leocadio Rodriguez-Mañas, Francisco José García-García
INTRODUCTION: Aging is a process that involves a reduction in muscle strength and anabolic hormone concentrations, which impacts significantly on health. AIM: To study the hormone/total strength (H/TS) ratio as a proxy of anabolic insensitivity status in elders, and its relationship with disability, hospitalization, and mortality risk. DESIGN: A total of 1462 persons aged ≥65 years from the Toledo Study of Healthy Aging participated in this study...
October 21, 2016: Journal of the American Medical Directors Association
Zhaowei Kong, Shengyan Sun, Min Liu, Qingde Shi
This study was to determine the effects of five-week high-intensity interval training (HIIT) on cardiorespiratory fitness, body composition, blood glucose, and relevant systemic hormones when compared to moderate-intensity continuous training (MICT) in overweight and obese young women. Methods. Eighteen subjects completed 20 sessions of HIIT or MICT for five weeks. HIIT involved 60 × 8 s cycling at ~90% of peak oxygen consumption ([Formula: see text]) interspersed with 12 s recovery, whereas MICT involved 40-minute continuous cycling at 65% of [Formula: see text]...
2016: Journal of Diabetes Research
Adela Brahimaj, Taulant Muka, Maryam Kavousi, Joop S E Laven, Abbas Dehghan, Oscar H Franco
AIMS/HYPOTHESIS: Previous literature documents controversial results for the impact of dehydroepiandrosterone (DHEA) in glucose metabolism. We aimed to assess the associations between serum levels of DHEA and its main derivatives DHEA sulphate (DHEAS) and androstenedione, as well as the ratio of DHEAS to DHEA, and risk of type 2 diabetes. METHODS: We used data on serum levels of DHEA, DHEAS and androstenedione from 5189 middle-aged and elderly men and women from the prospective population-based Rotterdam Study...
October 22, 2016: Diabetologia
Esra Özdil Demiryürek, Atilla Tekin, Engin Çakmak, Osman Temizkan, Oğuz Karamustafalıoğlu, Sibel Gökova, Enes Demiryürek
OBJECTIVE: The aim of this study was to investigate the relationship between anger, impulsiveness, and biochemical parameters (testosterone, insulin, insulin resistance) in women with polycystic ovary syndrome. STUDY DESIGN: We recruited 84 women diagnosed with polycystic ovary syndrome according to the Rotterdam diagnostic criteria. Psychiatric interviews were performed using the Structured Clinical Interview for DSM-IV Axis I Disorders. The Barratt Impulsiveness Scale and the State Trait Anger Expression Inventory were also administered to each participant...
October 6, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Katherine Amy Lin, Colin Rundel, P Murali Doraiswamy
BACKGROUND: Prior studies have noted gender differences in cognition, imaging, and pathological markers in mild cognitive impairment (MCI) subjects. Sex hormone-binding globulin (SHBG), a major controlling factor in the proportion of bioavailable versus bound testosterone and estrogen, has been proposed to contribute to links between hormones and dementia, but has not yet been investigated fully in a prospective biomarker trial. OBJECTIVE: This study examined whether, among subjects with MCI, SHBG levels predict future rate of cognitive decline...
October 20, 2016: Journal of Alzheimer's Disease: JAD
Karla Zanolla Dias de Souza, Fabiene Bernardes Castro Vale, Selmo Geber
OBJECTIVE: The objective of this study was to evaluate the efficacy of Tribulus terrestris for the treatment of hypoactive sexual desire disorder in postmenopausal women and evaluate its effect on the serum levels of testosterone. METHODS: We performed a prospective randomized, double-blinded, placebo-controlled study, during 18 months. A total of 45 healthy sexually active postmenopausal women reporting diminished libido were selected to participate in the study and were randomly assigned to receive 750 mg/d of T terrestris or placebo for 120 days...
October 10, 2016: Menopause: the Journal of the North American Menopause Society
Alex S Ribeiro, Brad J Schoenfeld, Steven J Fleck, Fábio L C Pina, Matheus A Nascimento, Edilson S Cyrino
The purpose of the present study was to investigate the effect of resistance training (RT) performed in a pyramid (PR) versus a traditional (TD) system on muscular strength, muscle mass, and hormonal responses in older women. Twenty-five older women (67.6 ± 5.1 years, 65.9 ± 11.1 kg, 154.7 ± 5.8 cm, and 27.5 ± 4.5 kg m) performed both a TD and PR system RT program in a balanced crossover design. The TD program consisted of 3 sets of 8-12 RM with a constant load for the 3 sets, whereas the PR system consisted of 3 sets of 12/10/8 RM with incrementally higher loads for each set...
September 23, 2016: Journal of Strength and Conditioning Research
Xiangrong Cui, Xuan Jing, Xueqing Wu, Meiqin Yan
Male infertility is a complex, multifactorial and polygenic disease that contributes to ~50% cases of infertility. Previous studies have demonstrated that excess weight and obesity factors serve an important role in the development of male infertility. An increasing number of studies have reported that resveratrol may regulate the response of cells to specific stimuli that induce cell injury, as well as decrease germ cell apoptosis in mice or rats. In the present study, the semen quality and serum sex hormone levels were evaluated in 324 men, which included 73 underweight, 82 normal weight, 95 overweight and 74 obese men...
October 12, 2016: Molecular Medicine Reports
Ushasi Banerjee, Anindya Dasgupta, Aparna Khan, Mrinal Kanti Ghosh, Pranab Roy, Jayanta Kumar Rout, Priyankar Roy, Suparna Dhara
BACKGROUND & OBJECTIVES: Insulin resistance (IR) is a major confounding factor in polycystic ovarian syndrome (PCOS) irrespective of obesity. Its exact mechanism remains elusive till now. C/T polymorphism in the -34 promoter region of the CYP17 gene is inconsistently attributed to elucidate the mechanism of IR and its link to hyperandrogenemia in obese PCOS patients. In the present study we aimed to evaluate any association of this polymorphism with IR in non-obese women with PCOS. METHODS: Polymorphism study was performed by restriction fragment length polymorphism (RFLP) analysis of the Msp A1 digest of the PCR product of the target gene in 75 PCOS cases against 73 age and BMI matched control women...
June 2016: Indian Journal of Medical Research
Batool Hossein Rashidi, Mansoureh Gorginzadeh, Soroush Aalipour, Eric Scott Sills
Objective: To compare serum anti-Müllerian hormone (AMH) and other endocrine parameters between patients diagnosed with polycystic ovary syndrome (PCOS) and age-matched ovulatory women. Materials and methods: AMH, DHEAS, FSH, LH, PRL, TSH and total testosterone (TT) were prospectively measured in oligo-ovulatory PCOS patients (n = 595) and in ovulatory non-PCOS women (n = 157) referred to a tertiary infertility center. Mean BMI was similar across the two study populations and there were no smokers in the sample...
October 10, 2016: Archives of Endocrinology and Metabolism
Marek Kociuba, Slawomir Kozieł, Raja Chakraborty, Zofia Ignasiak
Humans exhibit sex differences in competitiveness, sensation seeking and risk-taking attitude, which are required in sports. These attributes are often linked to prenatal testosterone (PT) exposure. The second-to-fourth digit length ratio (2D:4D) is an indicator of PT exposure. A lower 2D:4D indicates higher PT exposure and vice versa. Males generally have a lower 2D:4D than females. Sensation- and/or thrill-seeking behaviours have also been found to be negatively associated with 2D:4D. Boxing and judo are considered to be high-risk sports...
October 11, 2016: Journal of Biosocial Science
Shawn N Geniole, Brian M Bird, Erika L Ruddick, Justin M Carré
A contribution to a special issue on Hormones and Human Competition. Since Archer's (2006) influential meta-analysis, there has been a major increase in the number of studies investigating the effect of competition outcome on testosterone reactivity patterns in humans. Despite this increased research output, there remains debate as to whether competition outcome modulates testosterone concentrations. The present paper examines this question using a meta-analytic approach including papers published over the last 35years...
October 6, 2016: Hormones and Behavior
Linda Linton, Monica Taylor, Sheila Dunn, Lisa Martin, Sonia Chavez, Greg Stanitz, Ella Huszti, Salomon Minkin, Norman Boyd
BACKGROUND: In previous work in young women aged 15-30 years we measured breast water and fat using MR and obtained blood for hormone assays on the same day in the follicular phase of the menstrual cycle. Only serum growth hormone levels and sex hormone binding globulin (SHBG) were significantly associated with percent breast water after adjustment for covariates. The sex hormones estradiol, progesterone and testosterone were not associated with percent water in the breast in the follicular phase of the menstrual cycle...
2016: PloS One
Behzad S Khorashad, Zahra Aghili, Baudewijntje P C Kreukels, Mehran Hiradfar, Ghasem M Roshan, Mozhgan Afkhamizadeh, Mohammad Reza Abbaszadegan, Nosrat Ghaemi, Behnaz Khazai, Peggy Cohen Kettenis
INTRODUCTION: Few studies exist on the psychosexual outcome of homogeneous groups of individuals with 5α-reductase deficiency type 2 (5α-RD-2) and the relation between gender changes and parental hostile and benevolent sexism, which are two components of ambivalent sexism that assume a stereotypical approach toward women in an overtly negative way or a chivalrous, seemingly positive way. AIM: To report on the psychosexual outcome of individuals with 5α-RD-2 and to investigate its relation to the level of parental sexism in a relatively large sample of Iranians with 5α-RD-2...
September 29, 2016: Journal of Sexual Medicine
Kiki M G J Wigny, Wendy van Dorp, Anne-Lotte L F van der Kooi, Yolanda B de Rijke, Andrica C H de Vries, Marij Smit, Saskia M F Pluijm, Erica L T van den Akker, Rob Pieters, Joop S E Laven, Marry M van den Heuvel-Eibrink
STUDY QUESTION: Are Inhibin B and testosterone levels reduced in boys with newly diagnosed cancer prior to therapy? SUMMARY ANSWER: Pretreatment serum levels of Inhibin B and testosterone are significantly reduced in boys with newly diagnosed cancer, compared to reference values. WHAT IS ALREADY KNOWN: Disease-related gonadal impairment has been demonstrated in girls and young women diagnosed with cancer, prior to therapy. STUDY DESIGN, SIZE, DURATION: We conducted a descriptive study in boys newly diagnosed with cancer between January 2006 and February 2014...
September 28, 2016: Human Reproduction
Somayeh Hashemi, Fahimeh Ramezani Tehrani, Nader Mohammadi, Marzieh Rostami Dovom, Farahnaz Torkestani, Masumeh Simbar, Fereidoun Azizi
BACKGROUND: Premenstrual syndrome (PMS) is reported by up to 85% of women of reproductive age. Although several studies have focused on the hormone and lipid profiles of females with PMS, the results are controversial. OBJECTIVES: This study was designed to investigate the association of hormonal and metabolic factors with PMS among Iranian women of reproductive age. MATERIALS AND METHODS: This study was a community based cross-sectional study...
April 2016: International Journal of Endocrinology and Metabolism
Judyta E Nowak, Barbara A Borkowska, Boguslaw Z Pawlowski
BACKGROUND: Male gender and adiposity are considered to be risk factors for Staphylococcus aureus carriage. We tested whether colonization is related to free testosterone (fT) level and adiposity, measured with body mass index (BMI) and body fat percentage (BFP), in healthy adults. METHODS: Blood sample and throat swabs were taken twice (at 4-week intervals) from healthy men and women aged 18-36 years. fT level, height, weight, and BFP were measured. Participants were classified as persistent carriers, intermittent carriers (excluded from the analyses), and noncarriers...
September 23, 2016: American Journal of Infection Control
A Tölli, J Borg, B-M Bellander, F Johansson, C Höybye
PURPOSE: Reports on long-term variations in pituitary function after traumatic brain injury (TBI) and subarachnoid haemorrhage (SAH) diverge. The aim of the current study was to evaluate the prevalence and changes in pituitary function during the first year after moderate and severe TBI and SAH and to explore the relation between pituitary function and injury variables. METHODS: Adults with moderate and severe TBI or SAH were evaluated at 10 days, 3, 6 and 12 months post-injury/illness...
September 26, 2016: Journal of Endocrinological Investigation
Valentina Perrotta, Michele Graffeo, Nicolao Bonini, Jay A Gottfried
Putative human chemosignals have been shown to influence mood states and emotional processing, but the connection between these effects and higher-order cognitive processing is not well established. This study utilized an economic game (Dictator Game) to test whether androstadienone (AND), an odorous compound derived from testosterone, impacts on altruistic behavior. We predicted that the female participants would act more generously in the AND condition, exhibiting a significant interaction effect between gender and AND on Dictator Game contributions...
June 2016: Journal of Neuroscience, Psychology, and Economics
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