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https://www.readbyqxmd.com/read/29147956/endogenous-sex-hormones-and-memory-performance-in-middle-aged-greek-women-with-subjective-memory-complaints
#1
Eleni Armeni, Michail Apostolakis, Foteini Christidi, Demetrios Rizos, George Kaparos, Konstantinos Panoulis, Areti Augoulea, Andreas Alexandrou, Evangelia Karopoulou, Ioannis Zalonis, Nikolaos Triantafyllou, Irene Lambrinoudaki
The changing hormonal milieu during the menopausal transition may contribute to the development of memory disorders. We aimed to assess the association of sex hormones with memory function in a sample of Greek middle-aged women. This pilot study included 44 women with subjective memory complaints. Memory performance was evaluated using the Hopkins Verbal Learning Test (HVLT), the Brief Visuospatial Memory test (BVMT), and the verbal digits backwards test (VSPAN), to assess verbal, visuospatial, and working memory performance, respectively...
November 16, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29144548/anti-m%C3%A3-llerian-hormone-measurement-for-the-diagnosis-of-polycystic-ovary-syndrome
#2
Thozhukat Sathyapalan, Ahmed Al-Qaissi, Eric S Kilpatrick, Soha R Dargham, Stephen L Atkin
OBJECTIVE: Anti-Müllerian hormone (AMH) is derived from the small antral follicles and an elevated level has been suggested to add value to the Rotterdam criteria for the diagnosis of PCOS in cases of diagnostic uncertainty. Therefore, the role of AMH in the classical phenotype of PCOS was defined within a Caucasian population. DESIGN: This was a cross sectional study. PATIENTS: 65 women without PCOS and 110 women with PCOS fulfilling all 3 diagnostic Rotterdam criteria...
November 16, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29141657/local-estrogen-axis-in-the-human-bone-microenvironment-regulates-estrogen%C3%A2-receptor-positive%C3%A2-breast-cancer-cells
#3
Derek F Amanatullah, John S Tamaresis, Pauline Chu, Michael H Bachmann, Nhat M Hoang, Deborah Collyar, Aaron T Mayer, Robert B West, William J Maloney, Christopher H Contag, Bonnie L King
BACKGROUND: Approximately 70% of all breast cancers express the estrogen receptor, and are regulated by estrogen. While the ovaries are the primary source of estrogen in premenopausal women, most breast cancer is diagnosed following menopause, when systemic levels of this hormone decline. Estrogen production from androgen precursors is catalyzed by the aromatase enzyme. Although aromatase expression and local estrogen production in breast adipose tissue have been implicated in the development of primary breast cancer, the source of estrogen involved in the regulation of estrogen receptor-positive (ER+) metastatic breast cancer progression is less clear...
November 15, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29138989/sexual-function-and-sex-hormones-in-breast-cancer-patients
#4
Antonio Gambardella, Daniela Esposito, Giacomo Accardo, Marianna Taddeo, Antonietta Letizia, Rossella Tagliafierro, Katherine Esposito, Daniela Pasquali
PURPOSE: Breast cancer patients (BCP) are at risk of female sexual dysfunction (FSD). Our aim was to clarify the effects of treatment strategies, and steroid hormones levels on FSD. METHODS: We enrolled 136 BCP (46.9 ± 0.8 years), and 122 completed questionnaires. BCP were divided into four groups: 22 women with advanced breast cancer on neoadjuvant therapy (NAT), 48 on adjuvant therapy (AT), 30 taking hormonal therapy (HT) and 22 with metastatic cancer on first line chemotherapy (FLT)...
November 14, 2017: Endocrine
https://www.readbyqxmd.com/read/29136632/saturated-fat-intake-is-related-to-heart-rate-variability-in-women-with-polycystic-ovary%C3%A2-syndrome
#5
Scheila K Graff, Fernanda M Mario, Jose A Magalhães, Ruy S Moraes, Poli Mara Spritzer
BACKGROUND/AIMS: There is a heightened risk for cardiovascular diseases in women with polycystic ovary syndrome (PCOS). Alterations in heart rate variability (HRV) may reflect subclinical cardiovascular disease, with a putative association between HRV and dietary fat. This study evaluated HRV in PCOS and control women based on the dietary intake of saturated fatty acid (SFA). METHODS: Biochemical/hormonal profile, resting metabolic rate, physical activity, HRV in response to the Stroop test, and dietary intake were assessed in 84 PCOS and 54 control women stratified by median SFA intake in the PCOS group (8...
November 14, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29135292/-male-hormonal-contraception-past-present-future
#6
Norbert Pásztor, Borbála Eszter Hegyi, Attila Badó, Gábor Németh
In certain regions of the world the enormous rate of population growth raises economic and public health concerns and widely accessible contraceptive methods would be desired. In contrast, in other countries the use of effective contraception is a question of individual preferences. Today, most of the reliable contraceptive methods are applied by women, while the options for male methods are quite limited. It is well known that significant portion of pregnancies are still unplanned and several data revealed men's willingness to take part in family planning...
November 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29133833/effect-of-soy-on-bone-turn-over-markers-in-men-with-type-2-diabetes-and-hypogonadism-a-randomised-controlled-study
#7
T Sathyapalan, M Aye, A S Rigby, W D Fraser, E S Kilpatrick, S L Atkin
Type 2 diabetes (T2DM) is associated with increased risk of fractures. Soy supplementation has been shown to have a beneficial effect on bone turnover markers (BTM) in postmenopausal women. However, the effect of soy supplementation on BTM in T2DM and particularly in men is unclear. We performed an analysis of a randomized double blind parallel study of 200 men with T2DM treated with soy, either with or without isoflavones. Outcome measures were type I collagen crosslinked beta C-telopeptide (βCTX), and type 1 procollagen-N-propeptide (P1NP)...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29126102/mirna-513a-5p-inhibits-progesterone-receptor-expression-and-constitutes-a-risk-factor-for-breast-cancer-the-ordet-prospective-study
#8
P Muti, S Donzelli, A Sacconi, A Hossain, F Ganci, T Frixa, S Sieri, V Krogh, F Berrino, F Biagioni, S Strano, J Beyene, Y Yarden, G Blandino
MicroRNAs (miRNAs) might be considered both predictors and players of cancer development. The aim of the present report was to investigate whether many years before the diagnosis of breast cancer miRNA expression is already disregulated. In order to test this hypothesis we compared miRNAs extracted from leukocytes in healthy women who later developed breast cancer and in women who remain healthy during the whole fifteen-year follow-up time. Accordantly, we used a case-control study design nested in the ORDET prospective cohort study addressing the possibility that miRNAs can serve as both early biomarkers and components of the hormonal etiological pathways leading to breast cancer development in premenopausal women...
November 4, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29124543/determinants-of-prolactin-in-postmenopausal-chinese-women-in-singapore
#9
Tiffany A Katz, Anna H Wu, Frank Z Stanczyk, Renwei Wang, Woon-Puay Koh, Jian-Min Yuan, Steffi Oesterreich, Lesley M Butler
PURPOSE: Mechanistic and observational data together support a role for prolactin in breast cancer development. Determinants of prolactin in Asian populations have not been meaningfully explored, despite the lower risk of breast cancer in Asian populations. METHODS: Determinants of plasma prolactin were evaluated in 442 postmenopausal women enrolled in the Singapore Chinese Health Study, a population-based prospective cohort study. At baseline all cohort members completed an in-person interview that elicited information on diet, menstrual and reproductive history, and lifestyle factors...
November 9, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29122541/the-simultaneous-measurement-of-serum-testosterone-and-5%C3%AE-dihydrotestosterone-by-gas-chromatography-mass-spectrometry-gc-ms
#10
Frank Kannenberg, Manfred Fobker, Erhard Schulte, Grzegorz Pierściński, Reinhard Kelsch, Michael Zitzmann, Jerzy-Roch Nofer, Andreas N Schüring
BACKGROUND: Simultaneous measurement of testosterone (T) and 5α-dihydrotestosterone (DHT) is important for diagnosing androgen deficiency states and hyperandrogenism in males and females, respectively. However, immunoassays used for T and DHT determination suffer from inadequate specificity and sensitivity, while tandem mass spectrometry is expensive and demanding in use. METHODS AND RESULTS: We developed a selective gas chromatography-mass spectrometry (GC-MS) method for parallel T and DHT measurement...
November 6, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29097437/associations-of-endogenous-estradiol-and-testosterone-levels-with-plaque-composition-and-risk-of-stroke-in-subjects-with-carotid-atherosclerosis
#11
Marija Glisic, Blerim Mujaj, Oscar L Rueda-Ochoa, Eralda Asllanaj, Joop S Laven, Maryam Kavousi, M Kamran Ikram, Meike W Vernooij, M Arfan Ikram, Oscar H Franco, Daniel Bos, Taulant Muka
Rationale: Sex steroids may play a role in plaque composition and in stroke incidence. Objective: To study the associations of endogenous estradiol and testosterone with carotid plaque composition in elderly men and postmenopausal women with carotid atherosclerosis, as well as with risk of stroke in this population. Methods and Results: Data of 1023 postmenopausal women and 1124 men (≥45 years) with carotid atherosclerosis, from prospective population-based Rotterdam Study, were available. At baseline, total estradiol (TE) and total testosterone (TT) were measured...
November 2, 2017: Circulation Research
https://www.readbyqxmd.com/read/29097367/sex-chromosome-complement-defines-diffuse-versus-focal-angiotensin-ii-induced-aortic-pathology
#12
Yasir Alsiraj, Sean E Thatcher, Eric Blalock, Bradley Fleenor, Alan Daugherty, Lisa A Cassis
OBJECTIVE: Aortic pathologies exhibit sexual dimorphism, with aneurysms in both the thoracic and abdominal aorta (ie, abdominal aortic aneurysm [AAA]) exhibiting higher male prevalence. Women have lower prevalence of aneurysms, but when they occur, aneurysms progress rapidly. To define mechanisms for these sex differences, we determined the role of sex chromosome complement and testosterone on the location and progression of angiotensin II (AngII)-induced aortic pathologies. APPROACH AND RESULTS: We used transgenic male mice expressing Sry on an autosome to create Ldlr (low-density lipoprotein receptor)-deficient male mice with an XY or XX sex chromosome complement...
November 2, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29094914/testosterone-therapy-review-of-clinical-applications
#13
Ryan C Petering, Nathan A Brooks
Testosterone therapy is increasingly common in the United States, and many of these prescriptions are written by primary care physicians. There is conflicting evidence on the benefit of male testosterone therapy for age-related declines in testosterone. Physicians should not measure testosterone levels unless a patient has signs and symptoms of hypogonadism, such as loss of body hair, sexual dysfunction, hot flashes, or gynecomastia. Depressed mood, fatigue, decreased strength, and a decreased sense of vitality are less specific to male hypogonadism...
October 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/29094433/effects-of-vitamin-d-supplementation-on-insulin-sensitivity-and-androgen-levels-in-vitamin-d-deficient-polycystic-ovary-syndrome-patients
#14
Cihan Karadağ, Tevfik Yoldemir, Dilek Gogas Yavuz
AIM: The aim of this study was to identify the effects of vitamin D supplementation on insulin sensitivity and androgen levels in vitamin-D-deficient polycystic ovary syndrome (PCOS) patients. METHODS: Sixty-seven vitamin-D-deficient (25-hydroxyvitamin D [25(OH)D] levels below 20 ng/mL) PCOS patients and 54 vitamin-D-deficient non-PCOS volunteer subjects matched for age and body mass index were enrolled to this prospective study. All participants were given 50 000 IU/week cholecalciferol orally for 8 weeks and 1500 IU/day for 4 weeks...
November 2, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29090684/neuroactive-steroids-and-affective-symptoms-in-women-across-the-weight-spectrum
#15
Laura E Dichtel, Elizabeth A Lawson, Melanie Schorr, Erinne Meenaghan, Margaret Lederfine Paskal, Kamryn T Eddy, Graziano Pinna, Marianela Nelson, Ann M Rasmusson, Anne Klibanski, Karen K Miller
3α-5α-Tetrahydroprogesterone, a progesterone metabolite also known as allopregnanolone, and 5α-androstane-3α,17β-diol, a testosterone metabolite also known as 3α-androstanediol, are neuroactive steroids and positive GABAA receptor allosteric modulators. Both anorexia nervosa (AN) and obesity are complicated by affective co-morbidities and hypothalamic-pituitary-gonadal dysregulation. However, it is not known whether neuroactive steroid levels are abnormal at the extremes of the weight spectrum. We hypothesized that serum allopregnanolone and 3α-androstanediol levels would be decreased in AN compared to healthy controls (HC) and negatively associated with affective symptoms throughout the weight spectrum, independent of body mass index (BMI)...
November 1, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29079670/the-levels-of-adipokines-and-hormonal-changes-during-the-menstrual-cycle-in-normal-weight-women
#16
Katarzyna Wyskida, Grzegorz Franik, Tomasz Wikarek, Aleksander Owczarek, Alham Delroba, Jerzy Chudek, Jerzy Sikora, Magdalena Olszanecka-Glinianowicz
CONTEXT: The aim of this study was to assess plasma leptin, adiponectin, resistin, visfatin/NAMPT, omentin-1, vaspin, apelin, TNF-α, IL-6 and RBP4 levels in relation to hormonal changes during the menstrual cycle in young, healthy, normal-weight women. METHODS: The study involved 52 young, healthy, normal-weight women. Anthropometric parameters, body composition and levels of plasma leptin, adiponectin, resistin, visfatin/NAMPT, omentin-1, vaspin, apelin, TNF-α, IL-6 and RBP4 in addition to serum FSH, LH, estradiol, progesterone, 17-OH progesterone, androgens, SHBG and insulin concentrations were measured during a morning in fasting state three times: between days 2-4, days 12-14 and days 24-26 of the menstrual cycle...
October 27, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29077874/urinary-cadmium-excretion-is-associated-with-increased-synthesis-of-cortico-and-sex-steroids-in-a-population-study
#17
Murielle Bochud, Judith Jenny-Burri, Menno Pruijm, Belen Ponte, Idris Guessous, Georg Ehret, Dusan Petrovic, Vincent Dudler, Max Haldimann, Geneviève Escher, Bernhard Dick, Markus Mohaupt, Fred Paccaud, Michel Burnier, Antoinette Péchère-Bertschi, Pierre-Yves Martin, Bruno Vogt, Daniel Ackermann
Context: Urinary cadmium (Cd) excretion is associated with cancer and cardiovascular morbidity. A potential intermediate mechanism could be hormone-related by disturbing steroidogenesis in gonads and adrenal glands. Objective: We tested whether urinary Cd and the excretion of metabolites of sex and corticosteroids are correlated in the general adult population. Setting: The Swiss Kidney Project on Genes in Hypertension (SKIPOGH) is a multicentric family-based population study...
October 25, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29076960/effects-of-combined-strength-and-endurance-training-on-physical-performance-and-biomarkers-of-healthy-young-women
#18
Heikki KyrÖlÄinen, Anthony C Hackney, Riikka Salminen, Johanna Repola, Keijo HÄkkinen, Jari Haimi
Cardiovascular fitness has decreased and obesity has increased in youth-adults world-wide during the last ten years. Therefore, there is an urgent need to find out optimal exercise training programs for improving physical performance and health outcomes, especially, among sedentary women. Subjects were 25-30-year-old females with very low physical activity, and 65 % of them were overweight (BMI >25). They performed endurance and strength training three times a week for nine weeks. Independent strength training and instructed endurance training by indoor cycling were prescribed...
October 20, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29072028/differences-in-salivary-hormones-and-perception-of-exertion-in-elite-women-and-men-volleyball-players-during-tournament
#19
Luis E Peñailillo, Felipe A Escanilla, Esteban R Jury, Mauricio A Castro-Sepulveda, Louise Deldicque, Hermann P Zbinden-Foncea
Sports tournaments induce both psychological and physiological stress, which seems to be different between men and women. Competition induces anticipatory rises in testosterone and cortisol levels, which may affect performance and physical exertion during tournaments. PURPOSE: The aim of this study was to compare the changes in salivary cortisol and testosterone concentrations between men and women during an official volleyball tournament and to test potential correlations between changes in these hormones and perceived exertion after match...
October 24, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29068579/usefulness-of-a-new-anthropometric-indicator-vai-visceral-adiposity-index-in-the-evaluation-of-metabolic-and-hormonal-disorders-in-women-with-polycystic-ovary-syndrome
#20
Anna Brończyk-Puzoń, Paweł Jagielski, Karolina Kulik-Kupka, Aneta Koszowska, Justyna Nowak, Barbara Zubelewicz-Szkodzińska
BACKGROUND: Visceral adiposity index (VAI) is a new anthropometric indicator that makes it possible to define the risk of obesity-related cardiometabolic complications even before the diagnosis of metabolic syndrome. OBJECTIVES: Evaluating the usefulness of VAI in order to differentiate metabolically unhealthy women (MU-PCOS) and defining the usefulness of this index in everyday practice. MATERIAL AND METHODS: A prospective study was conducted among 43 women who met the Rotterdam criteria for diagnosing polycystic ovarian syndrome...
August 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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