Arif Ali Mandal, Virendra Singh, Sukanta Saha, Silda Peters, Tumpa Sadhukhan, Rajesh Kushwaha, Ashish Kumar Yadav, Apurba Mandal, Aarti Upadhyay, Arpan Bera, Arnab Dutta, Biplob Koch, Samya Banerjee
The relentless increase in drug resistance of platinum-based chemotherapeutics has opened the scope for other new cancer therapies with novel mechanisms of action (MoA). Recently, photocatalytic cancer therapy, an intrusive catalytic treatment, is receiving significant interest due to its multitargeting cell death mechanism with high selectivity. Here, we report the synthesis and characterization of three photoresponsive Ru(II) complexes, viz., [Ru(ph-tpy)(bpy)Cl]PF6 ( Ru1 ), [Ru(ph-tpy)(phen)Cl]PF6 ( Ru2 ), and [Ru(ph-tpy)(aip)Cl]PF6 ( Ru3 ), where, ph-tpy = 4'-phenyl-2,2':6',2″-terpyridine, bpy = 2,2'-bipyridine, phen = 1,10-phenanthroline, and aip = 2-(anthracen-9-yl)-1 H -imidazo[4,5- f ][1,10] phenanthroline, showing photocatalytic anticancer activity...
April 5, 2024: Inorganic Chemistry