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https://www.readbyqxmd.com/read/29165800/generic-versions-of-narrow-therapeutic-index-drugs-a-national-survey-of-pharmacists-substitution-beliefs-and-practices
#1
Ameet Sarpatwari, Moa P Lee, Joshua J Gagne, Zhigang Lu, Sarah K Dutcher, Wenlei Jiang, Eric G Campbell, Aaron S Kesselheim
Small changes in bioavailability of narrow therapeutic index (NTI) drugs can alter clinical outcomes, raising concern over generic NTI substitution. We surveyed pharmacists to identify their perceptions of generic NTI drugs, their frequency of performing generic NTI substitution, and predictors of this behavior. Of 710 respondents (33% response rate), 87% perceived generic NTI drugs as effective as their brand-name versions and 94% as safe. Whereas 82% almost always performed generic NTI substitution for initial prescriptions, only 60% did for refills...
November 22, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29165056/citrinin-induces-apoptosis-in-human-hct116-colon-cancer-cells-through-endoplasmic-reticulum-stress
#2
Amal Salah, Chayma Bouaziz, Alexandre Prola, Julie Pires Da Silva, Hassen Bacha, Salwa Abid-Essefi, Christophe Lemaire
The mycotoxin citrinin (CTN) is a natural contaminant of various human foods that may produce serious adverse health problems. Several studies demonstrated that citrinin exerts cytotoxic and genotoxic effects in both in vivo and in vitro systems. However, the precise mechanisms of action (MOA), particularly in intestinal cells remain unclear. The aim of the present study was to examine the precise MOA of citrinin in vitro. Data demonstrated that CTN significantly decreased the number of viable human intestinal HCT116 cells and induced apoptotic events including (1) decrease in ΔѰm indicative of mitochondrial membrane permeabilization, (2) activation of caspase 3, (3) elevated production of reactive oxygen species (ROS) and (4) relative persistence of plasma membrane integrity...
2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29162577/cohort-profile-the-mayo-clinic-cohort-study-of-oophorectomy-and-aging-2-moa-2-in-olmsted-county-minnesota-usa
#3
Walter A Rocca, Liliana Gazzuola Rocca, Carin Y Smith, Brandon R Grossardt, Stephanie S Faubion, Lynne T Shuster, Elizabeth A Stewart, Michelle M Mielke, Kejal Kantarci, Virginia M Miller
PURPOSE: This cohort study was established to investigate the effects of unilateral and bilateral oophorectomy on the ageing processes in women. PARTICIPANTS: We used the records-linkage system of the Rochester Epidemiology Project (REP, http://www.rochesterproject.org) to identify 570 women who underwent unilateral oophorectomy and 1653 women who underwent bilateral oophorectomy in Olmsted County, Minnesota from 1988 through 2007 (20 years). Each woman was matched by age (±1 year) to a population-based referent woman who had not undergone any oophorectomy (570 referent women) or bilateral oophorectomy (1653 referent women)...
November 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/29159133/integration-of-novel-approaches-demonstrates-simultaneous-metabolic-inactivation-and-car-mediated-hepatocarcinogenesis-of-a-nitrification-inhibitor
#4
Jessica L LaRocca, Reza J Rasoulpour, B Bhaskar Gollapudi, David L Eisenbrandt, Lynea A Murphy, Matthew J LeBaron
Nitrapyrin, a nitrification inhibitor, produces liver tumors in mice at high doses. Several experiments were performed to investigate molecular, cellular, and apical endpoints to define the key events leading to the tumor formation. These data support a mode-of-action (MoA) characterized by constitutive androstane receptor (CAR) nuclear receptor activation, increased hepatocellular proliferation leading to hepatocellular foci and tumor formation. Specifically, nitrapyrin induced a dose-related increase in the Cyp2b10/CAR-associated transcript and protein...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/29156432/the-effects-of-human-drugs-in-corbicula-fluminea-assessment-of-neurotoxicity-inflammation-gametogenic-activity-and-energy-status
#5
G V Aguirre-Martínez, C André, F Gagné, L M Martín-Díaz
The constant release of pharmaceuticals products to aquatic environment even at low concentrations (ng L(-1) to µg L(-1)) could lead to unknown chronic effects to non-target organisms. The aim of this study was to evaluate neurotoxic responses, inflammation, gametogenic activity and energy status on the fresh water clam C. fluminea after exposure to different concentrations of caffeine (CAF), ibuprofen (IBU), carbamazepine (CBZ), novobiocin (NOV) and tamoxifen (TMX) for 21 days under laboratory conditions...
November 17, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29143287/lipoic-acid-stimulates-camp-production-in-healthy-control-and-secondary-progressive-ms-subjects
#6
Sarah E Fiedler, Vijayshree Yadav, Amelia R Kerns, Catherine Tsang, Sheila Markwardt, Edward Kim, Rebecca Spain, Dennis Bourdette, Sonemany Salinthone
Lipoic acid (LA) exhibits antioxidant and anti-inflammatory properties; supplementation reduces disease severity and T lymphocyte migration into the central nervous system in a murine model of multiple sclerosis (MS), and administration in secondary progressive MS (SPMS) subjects reduces brain atrophy compared to placebo. The mechanism of action (MOA) of LA's efficacy in suppression of MS pathology is incompletely understood. LA stimulates production of the immunomodulator cyclic AMP (cAMP) in vitro. To determine whether cAMP could be involved in the MOA of LA in vivo, we performed a clinical trial to examine whether LA stimulates cAMP production in healthy control and MS subjects, and whether there are differences in the bioavailability of LA between groups...
November 15, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29142176/evaluation-of-the-human-relevance-of-the-constitutive-androstane-receptor-mediated-mode-of-action-for-rat-hepatocellular-tumor-formation-by-the-synthetic-pyrethroid-momfluorothrin
#7
Yu Okuda, Masahiko Kushida, Hiroko Kikumoto, Yoshimasa Nakamura, Hashihiro Higuchi, Satoshi Kawamura, Samuel M Cohen, Brian G Lake, Tomoya Yamada
High dietary levels of the non-genotoxic synthetic pyrethroid momfluorothrin increased the incidence of hepatocellular tumors in male and female Wistar rats. Mechanistic studies have demonstrated that the mode of action (MOA) for momfluorothrin-induced hepatocellular tumors is constitutive androstane receptor (CAR)-mediated. In the present study, to evaluate the potential human carcinogenic risk of momfluorothrin, the effects of momfluorothrin (1-1,000 µM) and a major metabolite Z-CMCA (5-1,000 µM) on hepatocyte replicative DNA synthesis and CYP2B mRNA expression were examined in cultured rat and human hepatocyte preparations...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29127803/development-of-thresholds-of-excess-toxicity-for-environmental-species-and-their-application-to-identification-of-modes-of-acute-toxic-action
#8
Jin J Li, Xu J Zhang, Yi Yang, Tao Huang, Chao Li, Limin Su, Yuan H Zhao, Mark T D Cronin
The acute toxicity of organic pollutants to fish, Daphnia magna, Tetrahymena pyriformis, and Vibrio fischeri was investigated. The results indicated that the Toxicity Ratio (TR) threshold of log TR =1, which has been based on the distribution of toxicity data to fish, can also be used to discriminate reactive or specifically acting compounds from baseline narcotics for Daphnia magna and Vibrio fischeri. A log TR=0.84 is proposed for Tetrahymena pyriformis following investigation of the relationships between the species sensitivity and the absolute averaged residuals (AAR) between the predicted baseline toxicity and the experimental toxicity...
November 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29124990/yoga-a-laborious-way-to-well-being-patients-experiences-of-yoga-as-a-treatment-for-hypertension-in-primary-care
#9
Moa Wolff, Annika Brorsson, Patrik Midlöv, Kristina Sundquist, Eva Lena Strandberg
OBJECTIVE: The aim of the study was to describe patients' experience of yoga as a treatment for hypertension, as well as their experience of living with hypertension. DESIGN: Qualitative interview study Method and materials: In 2013-2014, in southern Sweden, patients with hypertension from three health care centres were invited to participate in a randomised controlled trial on yoga for hypertension. After completion of the study, eight women and five men (aged 35-79), who had practiced the yoga intervention, were interviewed about their experiences...
November 10, 2017: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/29121465/co-culture-of-marine-invertebrate-associated-bacteria-and-interdisciplinary-technologies-enable-biosynthesis-and-discovery-of-a-new-antibiotic-keyicin
#10
Navid Adnani, Marc Chevrette, Srikar N Adibhatla, Fan Zhang, Qing Yu, Doug R Braun, Justin Nelson, Scott W Simpkins, Bradon R McDonald, Chad L Myers, Jeff S Piotrowski, Christopher J Thompson, Cameron R Currie, Lingjun Li, Scott R Rajski, Tim S Bugni
Advances in genomics and metabolomics have made clear in recent years that microbial biosynthetic capacities on Earth far exceed previous expectations. This is attributable, in part, to the realization that most microbial natural product (NP) producers harbor biosynthetic machineries not readily amenable to classical laboratory fermentation conditions. Such "cryptic" or dormant biosynthetic gene clusters (BGCs) encode for a vast assortment of potentially new antibiotics and, as such, have become extremely attractive targets for activation under controlled laboratory conditions...
November 9, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29120622/response-to-comment-on-mode-of-action-moa-assignment-classifications-for-ecotoxicology-an-evaluation-of-approaches
#11
A Kienzler, M G Barron, S E Belanger, A Beasley, M R Embry
No abstract text is available yet for this article.
November 9, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29120618/comment-on-mode-of-action-moa-assignment-classifications-for-ecotoxicology-an-evaluation-of-approaches
#12
Lynn S McCarty, Christopher J Borgert
No abstract text is available yet for this article.
November 9, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29114260/crosstalk-between-receptor-and-non-receptor-mediated-chemical-modes-of-action-in-rat-livers-converges-through-a-dysregulated-gene-expression-network-at-tumor-suppressor-tp53
#13
Karen M Funderburk, Scott S Auerbach, Pierre R Bushel
Chemicals, toxicants, and environmental stressors mediate their biologic effect through specific modes of action (MOAs). These encompass key molecular events that lead to changes in the expression of genes within regulatory pathways. Elucidating shared biologic processes and overlapping gene networks will help to better understand the toxicologic effects on biological systems. In this study we used a weighted network analysis of gene expression data from the livers of male Sprague-Dawley rats exposed to chemicals that elicit their effects through receptor-mediated MOAs (aryl hydrocarbon receptor, orphan nuclear hormone receptor, or peroxisome proliferator-activated receptor-α) or non-receptor-mediated MOAs (cytotoxicity or DNA damage)...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29113941/human-relevance-of-rodent-liver-tumors-key-insights-from-a-toxicology-forum-workshop-on-nongenotoxic-modes-of-action
#14
Susan P Felter, Jennifer E Foreman, Alan Boobis, J Christopher Corton, Adriana M Doi, Lynn Flowers, Jay Goodman, Lynne T Haber, Abigail Jacobs, James E Klaunig, Angela M Lynch, Jonathan Moggs, Arun Pandiri
The Toxicology Forum sponsored a workshop in October 2016, on the human relevance of rodent liver tumors occurring via nongenotoxic modes of action (MOAs). The workshop focused on two nuclear receptor-mediated MOAs (Constitutive Androstane Receptor (CAR) and Peroxisome Proliferator Activated Receptor-alpha (PPARα), and on cytotoxicity. The goal of the meeting was to review the state of the science to (1) identify areas of consensus and differences, data gaps and research needs; (2) identify reasons for inconsistencies in current regulatory positions; and (3) consider what data are needed to demonstrate a specific MOA, and when additional research is needed to rule out alternative possibilities...
November 4, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29100480/compound-functional-prediction-using-multiple-unrelated-morphological-profiling-assays
#15
France Rose, Sreetama Basu, Elton Rexhepaj, Anne Chauchereau, Elaine Del Nery, Auguste Genovesio
Phenotypic cell-based assays have proven to be efficient at discovering first-in-class therapeutic drugs mainly because they allow for scanning a wide spectrum of possible targets at once. However, despite compelling methodological advances, posterior identification of a compound's mechanism of action (MOA) has remained difficult and highly refractory to automated analyses. Methods such as the cell painting assay and multiplexing fluorescent dyes to reveal broadly relevant cellular components were recently suggested for MOA prediction...
November 1, 2017: SLAS Technology
https://www.readbyqxmd.com/read/29100207/genotoxicity-assessment-of-a-selected-cytostatic-drug-mixture-in-human-lymphocytes-a-study-based-on-concentrations-relevant-for-occupational-exposure
#16
Goran Gajski, Carina Ladeira, Marko Gerić, Vera Garaj-Vrhovac, Susana Viegas
Cytostatic drugs are highly cytotoxic agents used in cancer treatment and although their benefit is unquestionable, they have been recognized as hazardous to healthcare professionals in occupational settings. In a working environment, simultaneous exposure to cytostatics may occur creating a higher risk than that of a single substance. Hence, the present study evaluated the combined cyto/genotoxicity of a mixture of selected cytostatics with different mechanisms of action (MoA; 5-fluorouracil, cyclophosphamide and paclitaxel) towards human lymphocytes in vitro at a concentration range relevant for occupational as well as environmental exposure...
October 31, 2017: Environmental Research
https://www.readbyqxmd.com/read/29090320/gastrointestinal-parasites-of-captive-european-bison-bison-bonasus-l-with-a-sign-of-reduced-efficacy-of-haemonchus-contortus-to-fenbendazole
#17
Anna M Pyziel, Sven Björck, Rikard Wiklund, Moa Skarin, Aleksander W Demiaszkiewicz, Johan Höglund
The history of European bison Bison bonasus Linnaeus, 1758 has been stormy since its extinction in the wild after the First World War. Due to the fact that the species was restored from just 12 founders, further expansion has suffered from low genetic variability, rendering the bison vulnerable to various pathogens due to inbreeding depression. Parasites are recognised as a key biological threat to bison population. Thus, parasitological examination including monitoring of the level of anthelmintic resistance in a herd should be a routine procedure involved in management and protection of European bison...
October 31, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29081711/performance-of-the-atlas-track-reconstruction-algorithms-in-dense-environments-in-lhc-run-2
#18
M Aaboud, G Aad, B Abbott, J Abdallah, O Abdinov, B Abeloos, S H Abidi, O S AbouZeid, N L Abraham, H Abramowicz, H Abreu, R Abreu, Y Abulaiti, B S Acharya, S Adachi, L Adamczyk, J Adelman, M Adersberger, T Adye, A A Affolder, T Agatonovic-Jovin, C Agheorghiesei, J A Aguilar-Saavedra, S P Ahlen, F Ahmadov, G Aielli, S Akatsuka, H Akerstedt, T P A Åkesson, A V Akimov, G L Alberghi, J Albert, P Albicocco, M J Alconada Verzini, M Aleksa, I N Aleksandrov, C Alexa, G Alexander, T Alexopoulos, M Alhroob, B Ali, M Aliev, G Alimonti, J Alison, S P Alkire, B M M Allbrooke, B W Allen, P P Allport, A Aloisio, A Alonso, F Alonso, C Alpigiani, A A Alshehri, M Alstaty, B Alvarez Gonzalez, D Álvarez Piqueras, M G Alviggi, B T Amadio, Y Amaral Coutinho, C Amelung, D Amidei, S P Amor Dos Santos, A Amorim, S Amoroso, G Amundsen, C Anastopoulos, L S Ancu, N Andari, T Andeen, C F Anders, J K Anders, K J Anderson, A Andreazza, V Andrei, S Angelidakis, I Angelozzi, A Angerami, A V Anisenkov, N Anjos, A Annovi, C Antel, M Antonelli, A Antonov, D J Antrim, F Anulli, M Aoki, L Aperio Bella, G Arabidze, Y Arai, J P Araque, V Araujo Ferraz, A T H Arce, R E Ardell, F A Arduh, J-F Arguin, S Argyropoulos, M Arik, A J Armbruster, L J Armitage, O Arnaez, H Arnold, M Arratia, O Arslan, A Artamonov, G Artoni, S Artz, S Asai, N Asbah, A Ashkenazi, L Asquith, K Assamagan, R Astalos, M Atkinson, N B Atlay, K Augsten, G Avolio, B Axen, M K Ayoub, G Azuelos, A E Baas, M J Baca, H Bachacou, K Bachas, M Backes, M Backhaus, P Bagnaia, H Bahrasemani, J T Baines, M Bajic, O K Baker, E M Baldin, P Balek, F Balli, W K Balunas, E Banas, Sw Banerjee, A A E Bannoura, L Barak, E L Barberio, D Barberis, M Barbero, T Barillari, M-S Barisits, T Barklow, N Barlow, S L Barnes, B M Barnett, R M Barnett, Z Barnovska-Blenessy, A Baroncelli, G Barone, A J Barr, L Barranco Navarro, F Barreiro, J Barreiro Guimarães da Costa, R Bartoldus, A E Barton, P Bartos, A Basalaev, A Bassalat, R L Bates, S J Batista, J R Batley, M Battaglia, M Bauce, F Bauer, H S Bawa, J B Beacham, M D Beattie, T Beau, P H Beauchemin, P Bechtle, H P Beck, K Becker, M Becker, M Beckingham, C Becot, A J Beddall, A Beddall, V A Bednyakov, M Bedognetti, C P Bee, T A Beermann, M Begalli, M Begel, J K Behr, A S Bell, G Bella, L Bellagamba, A Bellerive, M Bellomo, K Belotskiy, O Beltramello, N L Belyaev, O Benary, D Benchekroun, M Bender, K Bendtz, N Benekos, Y Benhammou, E Benhar Noccioli, J Benitez, D P Benjamin, M Benoit, J R Bensinger, S Bentvelsen, L Beresford, M Beretta, D Berge, E Bergeaas Kuutmann, N Berger, J Beringer, S Berlendis, N R Bernard, G Bernardi, C Bernius, F U Bernlochner, T Berry, P Berta, C Bertella, G Bertoli, F Bertolucci, I A Bertram, C Bertsche, D Bertsche, G J Besjes, O Bessidskaia Bylund, M Bessner, N Besson, C Betancourt, A Bethani, S Bethke, A J Bevan, J Beyer, R M Bianchi, O Biebel, D Biedermann, R Bielski, N V Biesuz, M Biglietti, T R V Billoud, H Bilokon, M Bindi, A Bingul, C Bini, S Biondi, T Bisanz, C Bittrich, D M Bjergaard, C W Black, J E Black, K M Black, R E Blair, T Blazek, I Bloch, C Blocker, A Blue, W Blum, U Blumenschein, S Blunier, G J Bobbink, V S Bobrovnikov, S S Bocchetta, A Bocci, C Bock, M Boehler, D Boerner, D Bogavac, A G Bogdanchikov, C Bohm, V Boisvert, P Bokan, T Bold, A S Boldyrev, A E Bolz, M Bomben, M Bona, M Boonekamp, A Borisov, G Borissov, J Bortfeldt, D Bortoletto, V Bortolotto, D Boscherini, M Bosman, J D Bossio Sola, J Boudreau, J Bouffard, E V Bouhova-Thacker, D Boumediene, C Bourdarios, S K Boutle, A Boveia, J Boyd, I R Boyko, J Bracinik, A Brandt, G Brandt, O Brandt, U Bratzler, B Brau, J E Brau, W D Breaden Madden, K Brendlinger, A J Brennan, L Brenner, R Brenner, S Bressler, D L Briglin, T M Bristow, D Britton, D Britzger, F M Brochu, I Brock, R Brock, G Brooijmans, T Brooks, W K Brooks, J Brosamer, E Brost, J H Broughton, P A Bruckman de Renstrom, D Bruncko, A Bruni, G Bruni, L S Bruni, B H Brunt, M Bruschi, N Bruscino, P Bryant, L Bryngemark, T Buanes, Q Buat, P Buchholz, A G Buckley, I A Budagov, F Buehrer, M K Bugge, O Bulekov, D Bullock, T J Burch, H Burckhart, S Burdin, C D Burgard, A M Burger, B Burghgrave, K Burka, S Burke, I Burmeister, J T P Burr, E Busato, D Büscher, V Büscher, P Bussey, J M Butler, C M Buttar, J M Butterworth, P Butti, W Buttinger, A Buzatu, A R Buzykaev, S Cabrera Urbán, D Caforio, V M Cairo, O Cakir, N Calace, P Calafiura, A Calandri, G Calderini, P Calfayan, G Callea, L P Caloba, S Calvente Lopez, D Calvet, S Calvet, T P Calvet, R Camacho Toro, S Camarda, P Camarri, D Cameron, R Caminal Armadans, C Camincher, S Campana, M Campanelli, A Camplani, A Campoverde, V Canale, M Cano Bret, J Cantero, T Cao, M D M Capeans Garrido, I Caprini, M Caprini, M Capua, R M Carbone, R Cardarelli, F Cardillo, I Carli, T Carli, G Carlino, B T Carlson, L Carminati, R M D Carney, S Caron, E Carquin, S Carrá, G D Carrillo-Montoya, J Carvalho, D Casadei, M P Casado, M Casolino, D W Casper, R Castelijn, V Castillo Gimenez, N F Castro, A Catinaccio, J R Catmore, A Cattai, J Caudron, V Cavaliere, E Cavallaro, D Cavalli, M Cavalli-Sforza, V Cavasinni, E Celebi, F Ceradini, L Cerda Alberich, A S Cerqueira, A Cerri, L Cerrito, F Cerutti, A Cervelli, S A Cetin, A Chafaq, D Chakraborty, S K Chan, W S Chan, Y L Chan, P Chang, J D Chapman, D G Charlton, C C Chau, C A Chavez Barajas, S Che, S Cheatham, A Chegwidden, S Chekanov, S V Chekulaev, G A Chelkov, M A Chelstowska, C Chen, H Chen, S Chen, S Chen, X Chen, Y Chen, H C Cheng, H J Cheng, A Cheplakov, E Cheremushkina, R Cherkaoui El Moursli, V Chernyatin, E Cheu, L Chevalier, V Chiarella, G Chiarelli, G Chiodini, A S Chisholm, A Chitan, Y H Chiu, M V Chizhov, K Choi, A R Chomont, S Chouridou, V Christodoulou, D Chromek-Burckhart, M C Chu, J Chudoba, A J Chuinard, J J Chwastowski, L Chytka, A K Ciftci, D Cinca, V Cindro, I A Cioara, C Ciocca, A Ciocio, F Cirotto, Z H Citron, M Citterio, M Ciubancan, A Clark, B L Clark, M R Clark, P J Clark, R N Clarke, C Clement, Y Coadou, M Cobal, A Coccaro, J Cochran, L Colasurdo, B Cole, A P Colijn, J Collot, T Colombo, P Conde Muiño, E Coniavitis, S H Connell, I A Connelly, S Constantinescu, G Conti, F Conventi, M Cooke, A M Cooper-Sarkar, F Cormier, K J R Cormier, M Corradi, F Corriveau, A Cortes-Gonzalez, G Cortiana, G Costa, M J Costa, D Costanzo, G Cottin, G Cowan, B E Cox, K Cranmer, S J Crawley, R A Creager, G Cree, S Crépé-Renaudin, F Crescioli, W A Cribbs, M Cristinziani, V Croft, G Crosetti, A Cueto, T Cuhadar Donszelmann, A R Cukierman, J Cummings, M Curatolo, J Cúth, H Czirr, P Czodrowski, G D'amen, S D'Auria, L D'eramo, M D'Onofrio, M J Da Cunha Sargedas De Sousa, C Da Via, W Dabrowski, T Dado, T Dai, O Dale, F Dallaire, C Dallapiccola, M Dam, J R Dandoy, M F Daneri, N P Dang, A C Daniells, N S Dann, M Danninger, M Dano Hoffmann, V Dao, G Darbo, S Darmora, J Dassoulas, A Dattagupta, T Daubney, W Davey, C David, T Davidek, M Davies, D R Davis, P Davison, E Dawe, I Dawson, K De, R de Asmundis, A De Benedetti, S De Castro, S De Cecco, N De Groot, P de Jong, H De la Torre, F De Lorenzi, A De Maria, D De Pedis, A De Salvo, U De Sanctis, A De Santo, K De Vasconcelos Corga, J B De Vivie De Regie, W J Dearnaley, R Debbe, C Debenedetti, D V Dedovich, N Dehghanian, I Deigaard, M Del Gaudio, J Del Peso, T Del Prete, D Delgove, F Deliot, C M Delitzsch, A Dell'Acqua, L Dell'Asta, M Dell'Orso, M Della Pietra, D Della Volpe, M Delmastro, C Delporte, P A Delsart, D A DeMarco, S Demers, M Demichev, A Demilly, S P Denisov, D Denysiuk, D Derendarz, J E Derkaoui, F Derue, P Dervan, K Desch, C Deterre, K Dette, M R Devesa, P O Deviveiros, A Dewhurst, S Dhaliwal, F A Di Bello, A Di Ciaccio, L Di Ciaccio, W K Di Clemente, C Di Donato, A Di Girolamo, B Di Girolamo, B Di Micco, R Di Nardo, K F Di Petrillo, A Di Simone, R Di Sipio, D Di Valentino, C Diaconu, M Diamond, F A Dias, M A Diaz, E B Diehl, J Dietrich, S Díez Cornell, A Dimitrievska, J Dingfelder, P Dita, S Dita, F Dittus, F Djama, T Djobava, J I Djuvsland, M A B do Vale, D Dobos, M Dobre, C Doglioni, J Dolejsi, Z Dolezal, M Donadelli, S Donati, P Dondero, J Donini, J Dopke, A Doria, M T Dova, A T Doyle, E Drechsler, M Dris, Y Du, J Duarte-Campderros, A Dubreuil, E Duchovni, G Duckeck, A Ducourthial, O A Ducu, D Duda, A Dudarev, A Chr Dudder, E M Duffield, L Duflot, M Dührssen, M Dumancic, A E Dumitriu, A K Duncan, M Dunford, H Duran Yildiz, M Düren, A Durglishvili, D Duschinger, B Dutta, M Dyndal, C Eckardt, K M Ecker, R C Edgar, T Eifert, G Eigen, K Einsweiler, T Ekelof, M El Kacimi, R El Kosseifi, V Ellajosyula, M Ellert, S Elles, F Ellinghaus, A A Elliot, N Ellis, J Elmsheuser, M Elsing, D Emeliyanov, Y Enari, O C Endner, J S Ennis, J Erdmann, A Ereditato, G Ernis, M Ernst, S Errede, M Escalier, C Escobar, B Esposito, O Estrada Pastor, A I Etienvre, E Etzion, H Evans, A Ezhilov, M Ezzi, F Fabbri, L Fabbri, G Facini, R M Fakhrutdinov, S Falciano, R J Falla, J Faltova, Y Fang, M Fanti, A Farbin, A 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Sawyer, J Saxon, C Sbarra, A Sbrizzi, T Scanlon, D A Scannicchio, M Scarcella, V Scarfone, J Schaarschmidt, P Schacht, B M Schachtner, D Schaefer, L Schaefer, R Schaefer, J Schaeffer, S Schaepe, S Schaetzel, U Schäfer, A C Schaffer, D Schaile, R D Schamberger, V Scharf, V A Schegelsky, D Scheirich, M Schernau, C Schiavi, S Schier, L K Schildgen, C Schillo, M Schioppa, S Schlenker, K R Schmidt-Sommerfeld, K Schmieden, C Schmitt, S Schmitt, S Schmitz, U Schnoor, L Schoeffel, A Schoening, B D Schoenrock, E Schopf, M Schott, J F P Schouwenberg, J Schovancova, S Schramm, N Schuh, A Schulte, M J Schultens, H-C Schultz-Coulon, H Schulz, M Schumacher, B A Schumm, Ph Schune, A Schwartzman, T A Schwarz, H Schweiger, Ph Schwemling, R Schwienhorst, J Schwindling, A Sciandra, G Sciolla, F Scuri, F Scutti, J Searcy, P Seema, S C Seidel, A Seiden, J M Seixas, G Sekhniaidze, K Sekhon, S J Sekula, N Semprini-Cesari, S Senkin, C Serfon, L Serin, L Serkin, M Sessa, R Seuster, H Severini, T Sfiligoj, F 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Varol, D Varouchas, A Vartapetian, K E Varvell, J G Vasquez, G A Vasquez, F Vazeille, T Vazquez Schroeder, J Veatch, V Veeraraghavan, L M Veloce, F Veloso, S Veneziano, A Ventura, M Venturi, N Venturi, A Venturini, V Vercesi, M Verducci, W Verkerke, A T Vermeulen, J C Vermeulen, M C Vetterli, N Viaux Maira, O Viazlo, I Vichou, T Vickey, O E Vickey Boeriu, G H A Viehhauser, S Viel, L Vigani, M Villa, M Villaplana Perez, E Vilucchi, M G Vincter, V B Vinogradov, A Vishwakarma, C Vittori, I Vivarelli, S Vlachos, M Vlasak, M Vogel, P Vokac, G Volpi, H von der Schmitt, E von Toerne, V Vorobel, K Vorobev, M Vos, R Voss, J H Vossebeld, N Vranjes, M Vranjes Milosavljevic, V Vrba, M Vreeswijk, R Vuillermet, I Vukotic, P Wagner, W Wagner, J Wagner-Kuhr, H Wahlberg, S Wahrmund, J Wakabayashi, J Walder, R Walker, W Walkowiak, V Wallangen, C Wang, C Wang, F Wang, H Wang, H Wang, J Wang, J Wang, Q Wang, R Wang, S M Wang, T Wang, W Wang, W Wang, Z Wang, C Wanotayaroj, A Warburton, C P Ward, D R Wardrope, A Washbrook, P M Watkins, A T Watson, M F Watson, G Watts, S Watts, B M Waugh, A F Webb, S Webb, M S Weber, S W Weber, S A Weber, J S Webster, A R Weidberg, B Weinert, J Weingarten, M Weirich, C Weiser, H Weits, P S Wells, T Wenaus, T Wengler, S Wenig, N Wermes, M D Werner, P Werner, M Wessels, T D Weston, K Whalen, N L Whallon, A M Wharton, A S White, A White, M J White, R White, D Whiteson, B W Whitmore, F J Wickens, W Wiedenmann, M Wielers, C Wiglesworth, L A M Wiik-Fuchs, A Wildauer, F Wilk, H G Wilkens, H H Williams, S Williams, C Willis, S Willocq, J A Wilson, I Wingerter-Seez, E Winkels, F Winklmeier, O J Winston, B T Winter, M Wittgen, M Wobisch, T M H Wolf, R Wolff, M W Wolter, H Wolters, V W S Wong, S D Worm, B K Wosiek, J Wotschack, K W Wozniak, M Wu, S L Wu, X Wu, Y Wu, T R Wyatt, B M Wynne, S Xella, Z Xi, L Xia, D Xu, L Xu, B Yabsley, S Yacoob, D Yamaguchi, Y Yamaguchi, A Yamamoto, S Yamamoto, T Yamanaka, M Yamatani, K Yamauchi, Y Yamazaki, Z Yan, H Yang, H Yang, Y Yang, Z Yang, W-M Yao, Y C Yap, Y Yasu, E Yatsenko, K H Yau Wong, J Ye, S Ye, I Yeletskikh, E Yigitbasi, E Yildirim, K Yorita, K Yoshihara, C Young, C J S Young, J Yu, J Yu, S P Y Yuen, I Yusuff, B Zabinski, G Zacharis, R Zaidan, A M Zaitsev, N Zakharchuk, J Zalieckas, A Zaman, S Zambito, D Zanzi, C Zeitnitz, G Zemaityte, A Zemla, J C Zeng, Q Zeng, O Zenin, T Ženiš, D Zerwas, D Zhang, F Zhang, G Zhang, H Zhang, J Zhang, L Zhang, L Zhang, M Zhang, P Zhang, R Zhang, R Zhang, X Zhang, Y Zhang, Z Zhang, X Zhao, Y Zhao, Z Zhao, A Zhemchugov, B Zhou, C Zhou, L Zhou, M Zhou, M Zhou, N Zhou, C G Zhu, H Zhu, J Zhu, Y Zhu, X Zhuang, K Zhukov, A Zibell, D Zieminska, N I Zimine, C Zimmermann, S Zimmermann, Z Zinonos, M Zinser, M Ziolkowski, L Živković, G Zobernig, A Zoccoli, R Zou, M Zur Nedden, L Zwalinski
With the increase in energy of the Large Hadron Collider to a centre-of-mass energy of 13 [Formula: see text] for Run 2, events with dense environments, such as in the cores of high-energy jets, became a focus for new physics searches as well as measurements of the Standard Model. These environments are characterized by charged-particle separations of the order of the tracking detectors sensor granularity. Basic track quantities are compared between 3.2 fb[Formula: see text] of data collected by the ATLAS experiment and simulation of proton-proton collisions producing high-transverse-momentum jets at a centre-of-mass energy of 13 [Formula: see text]...
2017: European Physical Journal. C, Particles and Fields
https://www.readbyqxmd.com/read/29076867/patient-and-oncology-nurse-preferences-for-the-treatment-options-in-advanced-melanoma-a-discrete-choice-experiment
#19
Frank Xiaoqing Liu, Edward A Witt, Scot Ebbinghaus, Grace DiBonaventura Beyer, Enrique Basurto, Richard W Joseph
BACKGROUND: Understanding the perceptions of patients and oncology nurses about the relative importance of benefits and risks associated with newer treatments of advanced melanoma can help to inform clinical decision-making. OBJECTIVES: The aims of this study were to quantify and compare the views of patients and oncology nurses regarding the importance of attributes of treatments of advanced melanoma. METHODS: A discrete choice experiment (DCE) was conducted in US-based oncology nurses and patients diagnosed with advanced melanoma...
October 25, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/29071407/recombinant-proteins-and-monoclonal-antibodies
#20
Roy Jefferis
The human genome has become a subject of public interest, whilst the proteome remains the province of specialists. Less appreciated is the human glycoprotein (GP) repertoire (proteoglycome!); however, some 50% of open reading frame genes encode for proteins (P) that may accept the addition of N-linked and/or O-linked sugar chains (oligosaccharides). It is established that the attachment of defined oligosaccharide structures impacts mechanisms of action (MoAs), pharmacokinetics, pharmacodynamics, etc., and is a critical quality attribute (CQA) for recombinant GP therapeutics...
October 26, 2017: Advances in Biochemical Engineering/biotechnology
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