Henry T W Blest, Alexander Redmond, Jed Avissar, Jake Barker, Anne Bridgeman, Gerissa Fowler, Lise Chauveau, Jonny Hertzog, Iolanda Vendrell, Roman Fischer, Marie B Iversen, Lichen Jing, David M Koelle, Søren R Paludan, Benedikt M Kessler, Colin M Crump, Jan Rehwinkel
DNA sensing is important for antiviral immunity. The DNA sensor cGAS synthesizes 2'3'-cyclic GMP-AMP (cGAMP), a second messenger that activates STING, which induces innate immunity. cGAMP not only activates STING in the cell where it is produced but cGAMP also transfers to other cells. Transporters, channels, and pores (including SLC19A1, SLC46A2, P2X7, ABCC1, and volume-regulated anion channels (VRACs)) release cGAMP into the extracellular space and/or import cGAMP. We report that infection with multiple human viruses depletes some of these cGAMP conduits...
April 22, 2024: Cell Reports