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https://www.readbyqxmd.com/read/29748907/effect-of-combined-vitamin-d-receptor-activator-and-lanthanum-carbonate-on-serum-fibroblast-growth-factor-23-level-in-predialysis-patients-cvd-laf-study-design-and-method
#1
Eri Ito, Daijo Inaguma, Shigehisa Koide, Kazuo Takahashi, Hiroki Hayashi, Midori Hasegawa, Yukio Yuzawa
BACKGROUND: Whether vitamin D receptor activator (VDRA) use is beneficial in chronic kidney disease (CKD) is unclear, because it is possible that VDRA increases serum fibroblast growth factor 23 (FGF23) levels. We will conduct a randomized controlled trial in predialysis patients to determine the effect of VDRA alone or in combination with lanthanum carbonate (LC) on serum FGF23 levels. METHODS: This is a single-center, open-label, randomized controlled trial. Enrollment will commence February 1, 2018, using the following inclusion criteria: (1) age ≥ 20 years, (2) CKD with an estimated glomerular filtration rate of 10-45 mL/min/1...
May 10, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29745284/regional-and-temporal-variations-in-comorbidity-among-us-dialysis-patients-a-longitudinal-study-of-medicare-claims-data
#2
Yi Mu, Andrew I Chin, Abhijit V Kshirsagar, Yi Zhang, Heejung Bang
Medicare claims data are commonly used to query comorbidities for case-mix adjustment in research of patients with end-stage renal disease (ESRD) in the United States. These adjustments may affect reimbursement and quality rating through comparative profiling and ranking of dialysis facilities. We studied regional and temporal variations in comorbidity from claims data in the United States Renal Data System. Patients with a previous 1-year Medicare history who initiated dialysis therapy between 2006 and 2009 were examined with a follow-up period until 2012...
January 2018: Inquiry: a Journal of Medical Care Organization, Provision and Financing
https://www.readbyqxmd.com/read/29728316/cognitive-impairment-in-non-dialysis-dependent-ckd-and-the-transition-to-dialysis-findings-from-the-chronic-renal-insufficiency-cohort-cric-study
#3
Meera N Harhay, Dawei Xie, Xiaoming Zhang, Chi-Yuan Hsu, Eric Vittinghoff, Alan S Go, Stephen M Sozio, Jacob Blumenthal, Stephen Seliger, Jing Chen, Rajat Deo, Mirela Dobre, Sanjeev Akkina, Peter P Reese, James P Lash, Kristine Yaffe, Manjula Kurella Tamura
BACKGROUND: Advanced chronic kidney disease is associated with elevated risk for cognitive impairment. However, it is not known whether and how cognitive impairment is associated with planning and preparation for end-stage renal disease. STUDY DESIGN: Retrospective observational study. SETTING & PARTICIPANTS: 630 adults participating in the CRIC (Chronic Renal Insufficiency Cohort) Study who had cognitive assessments in late-stage CKD, defined as estimated glome-rular filtration rate ≤ 20mL/min/1...
May 2, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29724791/sleep-duration-and-health-related-quality-of-life-in-predialysis-ckd
#4
Su-Ah Sung, Young Youl Hyun, Kyu Beck Lee, Hayne Cho Park, Wookyung Chung, Yeong Hoon Kim, Yong-Soo Kim, Sue Kyung Park, Kook-Hwan Oh, Curie Ahn
BACKGROUND AND OBJECTIVES: Sleep duration has been associated with cardiometabolic risk and mortality. The health-related quality of life represents a patient's comprehensive perception of health and is accepted as a health outcome. We examined the relationship between sleep duration and health-related quality of life in predialysis CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In this cross-sectional study, data from 1910 adults with CKD enrolled in the Korean Cohort Study for Outcome in Patients with CKD were analyzed...
May 3, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29701806/high-fibroblast-growth-factor-23-is-associated-with-coronary-calcification-in-patients-with-high-adiponectin-analysis-from-the-korean-cohort-study-for-outcome-in-patients-with-chronic-kidney-disease-study
#5
Young Youl Hyun, Hyang Kim, Yun Kyu Oh, Kook-Hwan Oh, Curie Ahn, Su Ah Sung, Kyu Hun Choi, Soo Wan Kim, Kyu-Beck Lee
Background: The association between fibroblast growth factor 23 (FGF23) and coronary artery calcification (CAC) was inconclusive. Recently it was shown that adiponectin modulates renal handling of calcium and phosphorus. We hypothesized that adiponectin plays a role in the effect of FGF23 on CAC and explored whether the association between FGF23 and CAC is modified by serum adiponectin level in chronic kidney disease (CKD) patients. Methods: This cross-sectional study analyzed 1435 predialysis CKD patients from the Korean Cohort Study for Outcome in Patients with CKD cohort...
April 26, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29677039/time-to-reconsider-the-role-of-relative-blood-volume-monitoring-for-fluid-management-in-hemodialysis
#6
David F Keane, Paul Baxter, Elizabeth Lindley, Laura Rhodes, Sue Pavitt
Relative blood volume (RBV) monitoring during hemodialysis has been used to help guide fluid management for decades, although with little supporting evidence. The technique relies on the assumption that variation in RBV during fluid removal reflects the capacity for vascular refilling and that efficient refilling is related to fluid overload. This study investigated the relationship between RBV variation and bioimpedance-based fluid overload in 47 patients on stable hemodialysis. Mean treatment ultrafiltration volume (UFV) was 1...
April 18, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29621026/fluid-status-assessment-in-hemodialysis-patients-and-the-association-with-outcome-review-of-recent-literature
#7
Marijke J E Dekker, Jeroen P Kooman
PURPOSE OF REVIEW: In this review, we will discuss the most recent literature regarding fluids status assessment in hemodialysis patients, and the associations with outcome. RECENT FINDINGS: Research toward technique-assisted assessment of fluid status in hemodialysis patients has been going on for many years. However, there is no absolute agreement between techniques, such as bioimpedance, lung ultrasound, biochemical markers or vena caval diameter, likely because they reflect different fluid compartments with potentially altered distribution in hemodialysis patients...
May 2018: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29609536/effects-of-dialysate-to-serum-sodium-na-alignment-in-chronic-hemodialysis-hd-patients-retrospective-cohort-study-from-a-quality-improvement-project
#8
Jochen G Raimann, Linda H Ficociello, Len A Usvyat, Hanjie Zhang, Lisa Pacelli, Sandi Moore, Penny Sheppard, Qingqing Xiao, Yuedong Wang, Claudy Mullon, Paul Balter, Terry Sullivan, Peter Kotanko
BACKGROUND: Evidence indicates favorable effects of dialysate (DNa+ ) to serum sodium concentration (SNa+ ) alignment, however, results from larger sample populations are needed. For this reason, we conducted a retrospective propensity score-matched cohort study from a quality improvement project to investigate the effects of alignment on population of maintenance hemodialysis patients. METHODS: At 4 participating hemodialysis (HD) clinics, patients with SNa+ lower than the standard DNa+ of 137 mEq/L who received HD with DNa+ aligned to the average of the last 4 SNa+ measurements were evaluated (clinicaltrials...
April 2, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29603707/comparative-evaluation-of-periodontal-status-of-chronic-renal-failure-patients-and-systemically-healthy-individuals
#9
Radhika Gupta, Uttam Kumar, Siddharth Mallapragada, Pallavi Agarwal
AIM: Periodontitis, a chronic infectious disease, affects most of the population at one time or the other and its expression is a combination of hosts, microbial agents, and environmental factors. Extensive literature exists for the relationship between periodontal disease and diabetes mellitus, cardiovascular diseases, and adverse pregnancy outcomes. Only a few studies performed in a limited number of patients have reported peri-odontal health status in chronic renal failure patients...
March 1, 2018: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29583052/associations-between-dialysate-sodium-concentration-and-plasma-sodium-concentration-of-dogs-receiving-intermittent-hemodialysis-treatments
#10
Jonathan D Foster, Kenneth J Drobatz, Larry D Cowgill
OBJECTIVE To compare dialysate sodium concentration and patient plasma sodium concentration of dogs during intermittent hemodialysis treatments. SAMPLE 211 intermittent hemodialysis treatments performed on 40 client-owned dogs for the management of dialysis-dependent uremia. PROCEDURES Medical records were reviewed to determine the plasma sodium concentration of each dog before and after routine hemodialysis treatments. Associations between detected changes in plasma sodium concentration and dialysate sodium concentration were evaluated by use of Spearman rank correlations and linear regression analysis...
April 2018: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/29578403/patient-reported-outcomes-pros-argue-against-the-limited-use-of-peritoneal-dialysis-in-end-stage-renal-disease
#11
Carola W H de Fijter, Anouk T N van Diepen, Fariba Amiri, Friedo W Dekker, Ray T Krediet
AIM: Approximately 40% of dialysis patients are durably treated with peritoneal dialysis (PD) in our teaching hospital. Patients' perspectives were studied by patient-reported outcome measurements (PROMs) to find possible explanations for why the generally-reported decline in the use of PD hardly occurred in our facility. MATERIALS AND METHODS: All 75 prevalent adult dialysis patients hemodialysis (HD) duration 27, PD 16 months) were included. All had received predialysis care and education for > 6 month...
March 26, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/29534843/left-ventricular-mechanical-dispersion-and-global-longitudinal-strain-and-ventricular-arrhythmias-in-predialysis-and-dialysis-patients
#12
Liselotte C R Hensen, Kathleen Goossens, Tomaz Podlesnikar, Joris I Rotmans, J Wouter Jukema, Victoria Delgado, Jeroen J Bax
BACKGROUND: Patients with advanced chronic kidney disease (CKD) have high risk for sudden cardiac death (SCD) and may benefit from implantable cardioverter-defibrillators (ICDs). However, the risk for ICD-related complications is also high in this population. Therefore, there is an unmet need for accurate risk stratification tools to identify patients with CKD at risk for ventricular arrhythmias (VAs), who may benefit from ICD implantation. The aim of this hypothesis-generating study was to investigate the association between left ventricular (LV) mechanical dispersion and LV global longitudinal strain (GLS) measured using two-dimensional speckle-tracking echocardiography and VA and SCD in patients with CKD...
March 10, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29532981/effect-of-high-amylose-resistant-starch-ham-rs2-supplementation-on-biomarkers-of-inflammation-and-oxidative-stress-in-hemodialysis-patients-a-randomized-clinical-trial
#13
Hamid Tayebi Khosroshahi, Nosratola D Vaziri, Behzad Abedi, Bahlol Habibi Asl, Morteza Ghojazadeh, Wanghui Jing, Amir Mansur Vatankhah
INTRODUCTION: Systemic inflammation and oxidative stress play a central role in the pathogenesis of cardiovascular disease and numerous other complications of CKD. Recent studies demonstrated that consumption of a diet enriched with amylose (HAM-RS2), attenuates oxidative stress and inflammation, and improves intestinal microbiome in CKD rats. The present study was designed to explore the effect of dietary amylose supplementation in hemodialysis patients. METHODS: Forty-six stable hemodialysis patients were randomized to receive biscuits containing 20 g/day during the first four weeks and 25 g/day in the next four weeks of either HAM-RS2 or wheat-flour...
March 13, 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29529055/influence-of-dialysis-membrane-composition-on-plasma-bisphenol-a-levels-during-online-hemodiafiltration
#14
Sebastian Mas, Enrique Bosch-Panadero, Pedro Abaigar, Vanesa Camarero, Ignacio Mahillo, Esther Civantos, Didier Sanchez-Ospina, Alberto Ruiz-Priego, Jesus Egido, Alberto Ortiz, Emilio González-Parra
INTRODUCTION: Bisphenol A (BPA) is an ubiquitous environmental toxin that is also found in dialyzers. Online hemodiafiltration (OL-HDF) more efficiently clears high molecular weight molecules, and this may improve BPA clearance. However, the BPA contents of dialysis membranes may be a source of BPA loading during OL-HDF. METHODS: A prospective study assessed plasma BPA levels in OL-HDF patients using BPA-free (polynephron) or BPA-containing (polysulfone) dialyzers in a crossover design with two arms, after a run-in OL-HDF period of at least 6 months with the same membrane: 31 patients on polynephron at baseline were switched to polysulfone membranes for 3 months (polynephron-to-polysulfone) and 29 patients on polysulfone were switched to polynephron for 3 months (polysulfone-to-polynephron)...
2018: PloS One
https://www.readbyqxmd.com/read/29523566/long-term-clinical-parameters-after-switching-to-nocturnal-haemodialysis-a-dutch-propensity-score-matched-cohort-study-comparing-patients-on-nocturnal-haemodialysis-with-patients-on-three-times-a-week-haemodialysis-haemodiafiltration
#15
Thijs Thomas Jansz, Akin Özyilmaz, Muriel P C Grooteman, Tiny Hoekstra, Marieke Romijn, Peter J Blankestijn, Michael L Bots, Brigit C van Jaarsveld
OBJECTIVES: Nocturnal haemodialysis (NHD), characterised by 8-hour sessions ≥3 times a week, is known to improve clinical parameters in the short term compared with conventional-schedule haemodialysis (HD), generally 3×3.5-4 hours a week. We studied long-term effects of NHD and used patients on conventional HD/haemodiafiltration (HDF) as controls. DESIGN: Four-year prospective follow-up of patients who switched to NHD; we compared patients with patients on HD/HDF using propensity score matching...
March 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29507006/association-between-duration-of-predialysis-care-and-mortality-after-dialysis-start
#16
Ping Liu, Robert R Quinn, Matthew J Oliver, Paul E Ronksley, Brenda R Hemmelgarn, Hude Quan, Swapnil Hiremath, Aminu K Bello, Peter G Blake, Amit X Garg, John Johnson, Mauro Verrelli, James M Zacharias, Samar Abd ElHafeez, Marcello Tonelli, Pietro Ravani
BACKGROUND AND OBJECTIVES: Early nephrology referral is recommended for people with CKD on the basis of observational studies showing that longer nephrology care before dialysis start (predialysis care) is associated with lower mortality after dialysis start. This association may be observed because predialysis care truly reduces mortality or because healthier people with an uncomplicated course of disease will have both longer predialysis care and lower risk for death. We examined whether the survival benefit of longer predialysis care exists after accounting for the potential confounding effect of disease course that may also be affected by predialysis care...
March 5, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29495132/acid-base-assessment-of-patients-receiving-hemodialysis-what-are-our-management-goals
#17
F John Gennari
Acid-base assessment of patients receiving conventional hemodialysis (HD) has been based solely on predialysis serum [total CO2 ], and treatment is currently driven by the KDOQI guideline from 2000. This guideline was directed solely at minimizing metabolic acidosis and thereby improving bone and muscle metabolism. In 2000, no data were available to assess the effects of acid-base status on morbidity and mortality. Since then, new data have emerged from several large cohort studies about the association between variations in predialysis serum [total CO2 ], as well as blood pH, and morbidity and mortality risk...
March 1, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/29478048/association-between-heights-of-dialysis-patients-and-outcomes-results-from-a-retrospective-cohort-study-of-the-international-monitoring-dialysis-outcomes-mondo-database-initiative
#18
Samir Patel, Alice Topping, Xiaoling Ye, Hanjie Zhang, Bernard Canaud, Paola Carioni, Cristina Marelli, Adrian Guinsburg, Albert Power, Neill Duncan, Jeroen Kooman, Frank van der Sande, Len A Usvyat, Yuedong Wang, Xiaoqi Xu, Peter Kotanko, Jochen G Raimann
BACKGROUND: Tall people have improved metabolic profiles and better cardiovascular outcomes, a relationship inverted in dialysis patients. We investigated the relationship between height and outcomes in incident hemodialysis (HD) patients commencing treatment in an analysis of the international Monitoring Dialysis Outcomes (MONDO) database. METHODS: In this retrospective cohort study, we included incident HD patients commencing treatment between -January 1, 2006 and December 31, 2010 and investigated the association between height and mortality using the MONDO database...
2018: Blood Purification
https://www.readbyqxmd.com/read/29478020/chinese-observational-prospective-study-of-ageing-population-with-chronic-kidney-disease-c-option-a-study-protocol
#19
Shuang Liang, Wen-Ling Wang, Fang-Lei Zhu, Shu-Wei Duan, Xue-Feng Sun, Xiang-Mei Chen, Guang-Yan Cai
INTRODUCTION: The proportion of elderly people is steadily rising worldwide, especially in low-income and middle-income countries, including China. Chronic kidney disease (CKD) is a common disorder in older people. However, little is known about the epidemiology of CKD and its consequences among the elderly. Improvements on clinical guidelines and healthcare policies for this population are required. This study aims to examine the risk factors for progression of CKD among the elderly and develop models to identify subgroups who are at high risk...
February 24, 2018: BMJ Open
https://www.readbyqxmd.com/read/29464207/socioeconomic-inequalities-in-the-kidney-transplantation-process-a-registry-based-study-in-sweden
#20
Ye Zhang, Ulf-G Gerdtham, Helena Rydell, Johan Jarl
Background: Few studies have examined the association between individual-level socioeconomic status and access to kidney transplantation. This study aims to investigate the association between predialysis income and education, and access to (i) the kidney waitlist (first listing), and (ii) kidney transplantation conditional on waitlist placement. Adjustment will be made for a number of medical and nonmedical factors. Methods: The Swedish Renal Register was linked to national registers for adult patients in Sweden who started dialysis during 1995 to 2013...
February 2018: Transplantation Direct
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