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https://www.readbyqxmd.com/read/27923526/the-effect-of-intradialytic-intralipid-therapy-in-pediatric-hemodialysis-patients
#1
Orly Haskin, Scott M Sutherland, Cynthia J Wong
OBJECTIVE: Growth of children on maintenance hemodialysis is poor. Oral nutritional supplements are the preferred way to augment nutrition; however, many children have difficulties adhering to prescribed oral supplements. In our unit, we have been utilizing intralipid (IL) therapy as nutritional supplement during hemodialysis sessions. The aim of this study was to assess the safety, efficacy, and benefits of intradialytic IL therapy. DESIGN: A retrospective chart review...
December 3, 2016: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/27896908/bixalomer-in-hyperphosphatemic-patients-with-chronic-kidney-disease-not-on-dialysis-phase-3-randomized-trial
#2
Tadao Akizawa, Hideki Origasa, Chisato Kameoka, Junko Tsukada, Kentarou Kuroishi, Yusuke Yamaguchi
Currently, calcium- or metal-containing phosphate binders are available to treat hyperphosphatemia in predialysis patients with chronic kidney disease. Bixalomer, a non-calcium, metal-free phosphate binder, has not been studied in these patients. We evaluated the efficacy and safety of bixalomer versus placebo for treatment of hyperphosphatemia in Japanese predialysis patients with chronic kidney disease. This multicenter, randomized, double-blind, phase 3 trial, randomized eligible patients 1:1 to receive bixalomer or placebo for 12 weeks...
November 29, 2016: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/27884500/different-impact-of-aspirin-on-renal-progression-in-patients-with-predialysis-advanced-chronic-kidney-disease-with-or-without-previous-stroke
#3
Kuang-Chih Hsiao, Jing-Yang Huang, Chun-Te Lee, Tung-Wei Hung, Yung-Po Liaw, Horng-Rong Chang
BACKGROUND: The benefit of reducing the risk of stroke against increasing the risk of renal progression associated with antiplatelet therapy in patients with advanced chronic kidney disease (CKD) is controversial. METHODS: We enrolled 1301 adult patients with advanced CKD treated with erythropoiesis stimulating agents from January 1, 2002 to June 30, 2009 from the 2005 Longitudinal Health Insurance Database in Taiwan. All of the patients were followed until the development of the primary or secondary endpoints, or the end of the study (December 31, 2011)...
November 21, 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/27884399/cardiovascular-events-and-death-in-japanese-patients-with-chronic-kidney-disease
#4
Kenichi Tanaka, Tsuyoshi Watanabe, Ayano Takeuchi, Yasuo Ohashi, Kosaku Nitta, Tadao Akizawa, Seiichi Matsuo, Enyu Imai, Hirofumi Makino, Akira Hishida
The incidence of cardiovascular disease (CVD) is higher in patients with chronic kidney disease (CKD) than in the general population, and the risk of CVD increases with reductions in renal function. However, the incidence of CVD in Japanese patients with CKD has not been sufficiently investigated. To measure this we conducted the Chronic Kidney Disease Japan Cohort (CKD-JAC) Study over four years in 2,966 Japanese patients with CKD to examine the incidence of CVD and all-cause death. These patients had an estimated glomerular filtration rate (eGFR) of 10-59 ml/min/1...
November 21, 2016: Kidney International
https://www.readbyqxmd.com/read/27866964/dialysate-potassium-serum-potassium-mortality-and-arrhythmia-events-in-hemodialysis-results-from-the-dialysis-outcomes-and-practice-patterns-study-dopps
#5
Angelo Karaboyas, Jarcy Zee, Steven M Brunelli, Len A Usvyat, Daniel E Weiner, Franklin W Maddux, Allen R Nissenson, Michel Jadoul, Francesco Locatelli, Wolfgang C Winkelmayer, Friedrich K Port, Bruce M Robinson, Francesca Tentori
BACKGROUND: Sudden death is a leading cause of death in patients on maintenance hemodialysis therapy. During hemodialysis sessions, the gradient between serum and dialysate levels results in rapid electrolyte shifts, which may contribute to arrhythmias and sudden death. Controversies exist about the optimal electrolyte concentration in the dialysate; specifically, it is unclear whether patient outcomes differ among those treated with a dialysate potassium concentration of 3 mEq/L compared to 2 mEq/L...
November 17, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27844184/possible-prevention-of-uremic-nausea-by-vitamin-d-receptor-activators-in-non-dialysis-patients-with-stage-5-chronic-kidney-disease
#6
Masato Ikeda, Yoshimi Ueda, Yukio Maruyama, Keitaro Yokoyama, Takashi Yokoo, Nobuhiko Joki, Ryoichi Ando, Toshio Shinoda, Daijo Inaguma, Toshihiko Yamaka, Yasuhiro Komatsu, Fumihiko Koiwa, Toshifumi Sakaguchi, Shigeo Negi, Takashi Shigematsu
BACKGROUND: Nausea is a major uremic symptom and a frequent indication for starting dialysis. However, preventive medication for uremic nausea has not yet been identified. Vitamin D receptor activators (VDRAs) may prevent uremic nausea via their pleiotropic actions. The objective of this study was to explore whether VDRA administration during the predialysis period is associated with a reduced prevalence of uremic nausea just prior to beginning dialysis. METHODS: A multicenter, retrospective, cross-sectional study was performed to identify a medication to prevent uremic nausea...
November 14, 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/27843345/the-danish-nephrology-registry
#7
REVIEW
James Heaf
AIM OF DATABASE: The Danish Nephrology Registry's (DNR) primary function is to support the Danish public health authorities' quality control program for patients with end-stage renal disease in order to improve patient care. DNR also supplies epidemiological data to several international organizations and supports epidemiological and clinical research. STUDY POPULATION: The study population included patients treated with dialysis or transplantation in Denmark from January 1, 1990 to January 1, 2016, with retrospective data since 1964...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27830383/cortical-bone-analysis-in-a-predialysis-population-a-comparison-with-a-dialysis-population
#8
Catarina Carvalho, J Magalhães, R Neto, L Pereira, P Branco, T Adragão, J M Frazão
This study was designed to characterize cortical bone by histomorphometry in a predialysis population, to correlate turnover, mineralization, and volume between cortical and trabecular bone, and to compare the findings with those in patients treated with maintenance dialysis. We evaluated cortical bone by histomorphometry in 16 patients with stage 3 or stage 4 chronic kidney disease and in 16 dialysis patients. Dual-energy X-ray absorptiometry (DXA) of the distal end of the forearm was performed in seven predialysis patients, and the findings correlated with histologic parameters...
November 9, 2016: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/27822135/chronic-kidney-disease-identification-and-management-in-primary-care
#9
REVIEW
Simon Ds Fraser, Tom Blakeman
Chronic kidney disease (CKD) is an important and common noncommunicable condition globally. In national and international guidelines, CKD is defined and staged according to measures of kidney function that allow for a degree of risk stratification using commonly available markers. It is often asymptomatic in its early stages, and early detection is important to reduce future risk. The risk of cardiovascular outcomes is greater than the risk of progression to end-stage kidney disease for most people with CKD...
2016: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/27816311/the-diagnosis-of-sarcopenia-is-mainly-driven-by-muscle-mass-in-hemodialysis-patients
#10
Stanislas Bataille, Marianne Serveaux, Elisa Carreno, Nathalie Pedinielli, Patrice Darmon, Alain Robert
BACKGROUND & AIMS: Sarcopenia is a well-known complication of protein energy wasting in hemodialysis patients. Its diagnosis requires measurements of muscle mass and muscle function. Few studies have reported its prevalence in hemodialysis patients. In this study, we report the prevalence of sarcopenia in this population and evaluate the performance of other parameters for its diagnosis. METHODS: In this observational cross-sectional study, data from hemodialysis patients from our nephrology department were recorded...
October 22, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27798434/blunted-muscle-vasodilatory-response-during-mental-stress-in-predialysis-nondiabetic-patients-a-cross-sectional-study
#11
Pedro A C Mira, Isabelle M G Freitas, Daniel G Martinez, Jorge R P Lima, Rogério B Paula, Mateus C Laterza
No abstract text is available yet for this article.
December 2016: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/27772639/intensive-hemodialysis-blood-pressure-and-antihypertensive-medication-use
#12
George L Bakris, John M Burkart, Eric D Weinhandl, Peter A McCullough, Michael A Kraus
Hypertension is a cardinal feature of end-stage renal disease (ESRD). Hypertensive nephropathy is the primary cause of ESRD for nearly 30% of patients, and the prevalence of hypertension is >85% in new patients with ESRD. In contemporary hemodialysis (HD) patients, mean predialysis systolic blood pressure (SBP) is nearly 150mmHg, and about 70%, 50%, and 40% use β-blockers, calcium channel blockers, and renin-angiotensin system inhibitors, respectively. Predialysis SBP generally exhibits a U-shaped association with mortality risk...
November 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27752007/chemerin-a-biomarker-for-cardiovascular-disease-in-diabetic-chronic-kidney-disease-patients
#13
Farag E Salama, Qasem A Anass, Abdelnaem A Abdelrahman, Elsayed B Saeed
Cardiovascular disease is the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). The carotid intima-media thickness (CIMT) and arterial stiffness are useful markers of subclinical atherosclerosis and significantly correlate with various metabolic risk factors. Chemerin is one of the adipokines that may represent a link between obesity and inflammation and may be a potential candidate playing a role in the pathogenesis of atherosclerosis and cardiovascular complications. Therefore, we studied the relationship of chemerin levels with atherosclerosis as measured by CIMT in diabetic CKD patients, either predialysis or on hemodialysis (HD)...
September 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27738228/a-two-pool-kinetic-model-predicts-phosphate-concentrations-during-and-shortly-following-a-conventional-three-times-weekly-hemodialysis-session
#14
John T Daugirdas
BACKGROUND: Previous studies have suggested that a conventional two-pool model cannot be used to predict intradialysis and early postdialysis phosphorus concentrations. METHODS: A conventional two-pool urea model was modified by increasing the distal compartment volume from two-thirds to three times the total body water and by the use of a dynamically variable intercompartmental phosphorus clearance during dialysis. The phosphate solver model parameters were derived from an examination of the results in the literature, and fine-tuned using a training set (F4) of 415 Hemodialysis (HEMO) Study patients studied during a dialysis session where phosphorus was measured at 4 months of follow-up...
October 13, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27736816/causes-and-consequences-of-interdialytic-weight-gain
#15
Karin J R Ipema, Johanna Kuipers, Ralf Westerhuis, Carlo A J M Gaillard, Cees P van der Schans, Wim P Krijnen, Casper F M Franssen
BACKGROUND/AIMS: Higher interdialytic weight gain (IDWG) is associated with higher predialysis blood pressure and increased mortality. IDWG is also increasingly being recognized as an indicator of nutritional status. We studied in detail the associations of various patient factors and nutritional parameters with IDWG. METHODS: We collected data during one week for IDWG and hemodynamic parameters in 138 prevalent adult haemodialysis patients on a thrice-weekly haemodialysis schedule...
2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27699876/estimating-time-averaged-serum-urea-nitrogen-concentration-during-various-urine-collection-periods-a-prediction-equation-for-thrice-weekly-and-biweekly-dialysis-schedules
#16
John T Daugirdas
Residual kidney urea clearance in dialysis patients typically is calculated as the per minute excretion of urea nitrogen, obtained during the 24-48 hour collection period that usually ends just prior to a dialysis session, divided by the time-averaged serum water urea nitrogen concentration during the collection period. This concentration is difficult to estimate unless a formal kinetic modeling program is being used. We used a urea kinetic modeling program to derive an equation to estimate the time-averaged serum water concentration during urine collection periods of various lengths collected during various interdialytic intervals, for 3/week or 2/week dialysis schedules...
November 2016: Seminars in Dialysis
https://www.readbyqxmd.com/read/27692989/serum-adiponectin-and-protein-energy-wasting-in-predialysis-chronic-kidney-disease
#17
Young Youl Hyun, Kyu-Beck Lee, Kook-Hwan Oh, Curie Ahn, Sue Kyung Park, Dong Wan Chae, Tae-Hyun Yoo, Kyu Hun Cho, Yong-Soo Kim, Young-Hwan Hwang
OBJECTIVE: Adiponectin (ADPN) has antiatherogenic, anti-inflammatory, and insulin-sensitizing effects. Serum ADPN levels are increased in patients with chronic kidney diseases (CKD), and higher ADPN is paradoxically a predictor of mortality in these patients. The aim of this study was to determine the association between serum ADPN levels and protein-energy wasting (PEW) in predialysis CKD. METHOD: We examined serum ADPN concentrations and PEW in 1303 patients from the KNOW-CKD (KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease) study...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27679723/renew-a-renal-redesign-project-in-predialysis-patient-care
#18
Josephine Sau Fan Chow, Kim Jobburn, Margaret Chapman, Michael Suranyi
BACKGROUND: An ageing population and geographical growth, along with an increase in the number of people that reside in specific location, are increasing the demand for renal replacement therapies. Hospital-based haemodialysis units are struggling to cope with the associated physical, staffing and cost demands. Home-based dialysis therapies are known to be more cost effective with superior social, physical health and survival outcomes. METHODS: 'RENEW, a renal redesign project, examined the pre-dialysis health care experience of renal patients to find opportunities to improve patient care outcomes and increase the uptake of home-based dialysis therapies...
October 2016: Clinical Kidney Journal
https://www.readbyqxmd.com/read/27661097/blood-pressure-and-mortality-in-long-term-hemodialysis-time-to-move-forward
#19
REVIEW
Panagiotis I Georgianos, Rajiv Agarwal
Contrary to the direct, graded, and causal relationship of hypertension with cardiovascular outcomes in the general population, among dialysis patients, blood pressure (BP) recorded either predialysis or postdialysis displays a U-shaped curve with mortality. This paradoxical phenomenon of lower BP or a decline in BP over time being associated with increased mortality and higher BP being associated with a lower mortality is described as "reverse" epidemiology of hypertension, raising substantial controversy on whether BP lowering causes harms or benefits among dialysis patients...
September 22, 2016: American Journal of Hypertension
https://www.readbyqxmd.com/read/27647184/mineral-and-bone-disorder-and-its-association-with-cardiovascular-parameters-in-chinese-patients-with-chronic-kidney-disease
#20
Chu Zhou, Fang Wang, Jin-Wei Wang, Lu-Xia Zhang, Ming-Hui Zhao
BACKGROUND: Mineral and bone disorder (MBD), especially hyperphosphatemia, is an independently risk factor for adverse prognosis in patients with chronic kidney disease (CKD). However, CKD-MBD among Chinese population was poorly studied. This study aimed to investigate the status of MBD and its association with cardiovascular parameters in Chinese patients with predialysis CKD. METHODS: Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE) is a prospective multicenter cohort study involving predialysis CKD patients in China...
2016: Chinese Medical Journal
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