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Fat transplant

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https://www.readbyqxmd.com/read/29466361/is-there-relationship-between-epicardial-fat-and-cardiovascular-parameters-in-incident-kidney-transplant-patients-a-post-hoc-analysis
#1
Daniel Constantino Yazbek, Aluizio Barbosa Carvalho, Cinara Sa Barros, Jose Osmar Medina Pestana, Carlos Eduardo Rochitte, Raul Dias Dos Santos Filho, Maria Eugênia F Canziani
BACKGROUND: Epicardial fat (EF) has been related to increased cardiovascular risk in chronic kidney disease patients. Kidney transplantation is associated with weight gain, especially within the first 12 months. Recently an association between EF and left ventricular mass (LVM) has been suggested in kidney transplant (KTX) recipients. OBJECTIVE: Evaluate the EF in KTX recipients and its association with cardiovascular parameters in a 12-month follow-up study. METHODS: EF volume was determined using thoracic computed tomography...
2018: PloS One
https://www.readbyqxmd.com/read/29465484/expansion-vibration-lipofilling-evl-a-new-technique-in-large-volume-fat-transplantation
#2
Daniel Del Vecchio, Simeon Wall
INTRODUCTION: Despite rapid growth, gluteal fat transplantation is an operation in search of science and a teachable technique. Long operating times, tedious syringe transfers, inability to shape the recipient site and the risk of fat embolism all headline as impediments to clinical adoption of the procedure. Expansion Vibration Lipofilling - EVL - is a syringe-free surgical strategy which is a logical extension of SAFE® liposuction. In EVL, there is simultaneous disruption of recipient site connective tissue, internal expansion using exploded-tip cannulas and backfilling of these spaces with roller pump-propelled fat...
February 9, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29461295/labia-majora-augmentation-combined-with-minimal-labia-minora-resection-a-safe-and-global-approach-to-the-external-female-genitalia
#3
Barbara Hersant, Samer Jabbour, Warren Noel, Laurent Benadiba, Simone La Padula, Mounia SidAhmed-Mezi, Jean Paul Meningaud
BACKGROUND: All the labia minora reduction techniques fail to treat the other component of the abnormally increased labia minora to majora ratio: the labia majora atrophy. The purpose of this study is to describe a technique of female genitalia beautification, which combines labia majora augmentation and conservative labia minora reduction. METHODS: The hypertrophied labia minora were first treated by a conservative inferior wedge excision with a superior flap. The conservative excision was done to obtain labia minora that would still protrude beyond the labia majora because it will be masked by the augmentation of the labia majora...
February 15, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29460474/specific-synbiotics-in-early-life-protect-against-diet-induced-obesity-in-adult-mice
#4
Mona Mischke, Tulika Arora, Sebastian Tims, Eefje Engels, Nina Sommer, Kees van Limpt, Annemarie Baars, Raish Oozeer, Annemarie Oosting, Fredrik Bäckhed, Jan Knol
AIMS: The metabolic state of human adults is associated with their gut microbiome. The symbiosis between host and microbiome is initiated at birth, and early life microbiome perturbation can disturb health long-lastingly. Here, we determined how beneficial microbiome interventions in early life affect metabolic health in adulthood. METHODS: Postnatal diets were supplemented with either prebiotics (scGOS/lcFOS) or synbiotics (scGOS/lcFOS with Bifidobacterium breve M-16V) until post-natal (PN) day 42 in a well-established rodent model for nutritional programming...
February 20, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29449334/rgc-32-response-gene-to-complement-32-protein-deficiency-protects-endothelial-cells-from-inflammation-and-attenuates-atherosclerosis
#5
Xiao-Bing Cui, Jun-Na Luan, Kun Dong, Sisi Chen, Yongyi Wang, Wendy T Watford, Shi-You Chen
OBJECTIVE: The objective of this study is to determine the role and underlying mechanisms of RGC-32 (response gene to complement 32 protein) in atherogenesis. APPROACH AND RESULTS: RGC-32 was mainly expressed in endothelial cells of atherosclerotic lesions in both ApoE -/- (apolipoprotein E deficient) mice and human patients. RGC-32 deficiency (Rgc32 -/- ) attenuated the high-fat diet-induced and spontaneously developed atherosclerotic lesions in ApoE -/- mice without affecting serum cholesterol concentration...
February 15, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29444672/adherence-to-mediterranean-and-low-fat-diets-among-heart-and-lung-transplant-recipients-a-randomized-feasibility-study
#6
Timothy R Entwistle, Adèle C Green, James E Fildes, Kyoko Miura
BACKGROUND: Heart and lung transplant recipients are at a substantially increased risk of cardiovascular disease (CVD). Since both low-fat and Mediterranean diets can reduce CVD in immunocompetent people at high risk, we assessed adherence among thoracic transplant recipients allocated to one or other of these diets for 12 months. METHODS: Forty-one transplant recipients (20 heart; 21 lung) randomized to a Mediterranean or a low-fat diet for 12 months received diet-specific education at baseline...
February 14, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29438465/does-stromal-vascular-fraction-ensure-a-higher-survival-in-autologous-fat-grafting-for-breast-augmentation-a-volumetric-study-using-3-dimensional-laser-scanning
#7
Cheng-Hung Chiu
Background: Cell-assisted lipotransfer (CAL) has been considered a promising technique for promoting adipogenesis and angiogenesis in fat grafts. Objectives: The author sought to objectively analyze the change of breast volume in patients who underwent stromal vascular fraction (SVF)-enriched fat grafting for breast augmentation and compared the clinical results with those who underwent conventional fat grafting without SVF by using 3D laser scanning. Methods: From April 2015 to March 2016, 105 patients who underwent traditional fat grafting without SVF enrichment for breast augmentation were assigned to group A and served as the control...
February 9, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29436657/effect-of-notoginsenoside-r1-on-autologous-adipose-graft-in-rats
#8
Guizong Chen, Qin Li, Yanping Luo, Tao Liu, Shaolong Zhou, Er Pan, Lixia Peng
Autologous fat particle transplantation has been widely used by surgeons. The present study evaluated the effect of Notoginsenoside R1 (NR1) treatment on rat autologous fat graft, along with the quality and retention rates. Male Sprague‑Dawley rats (n=60) received fat particle auto‑transplantation from the left abdominal cavity into lateral dorsum. A total of 14 days after surgery, NR1 in different doses (50, 100 and 200 mg/kg/day) was injected into rats, following which blood and fat graft samples were harvested at days 7, 14 and 28...
February 13, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29428734/co-transplantation-of-exosomes-derived-from-hypoxia-preconditioned-adipose-mesenchymal-stem-cells-promotes-neovascularization-and-graft-survival-in-fat-grafting
#9
Yu-di Han, Yun Bai, Xin-Long Yan, Jing Ren, Quan Zeng, Xiao-Dong Li, Xue-Tao Pei, Yan Han
BACKGROUND: Adipose-derived stromal cells (ADSCs)-derived exosomes (ADSC-Exos) account for the proangiogenic potential of stem cell. This study aimed to investigate the effect of ADSC-derived exosomes (ADSC-Exos) on the survival in fat grafting. METHODS: A nude mouse model of subcutaneous fat grafting was adopted. Hypoxic preconditioned ADSC-Exos and ADSC-Exos were injected around the grafted tissue. The fat graft sample was weighed and examined by hematoxylin and eosin (H&E) staining and immunohistochemistry...
February 8, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29421860/-face-transplantation-current-status-and-future-developments
#10
REVIEW
Sotirios Tasigiorgos, Branislav Kollar, Nicco Krezdorn, Ericka M Bueno, Stefan G Tullius, Bohdan Pomahac
More than thirty-five facial allograft transplantations (FAT) have been reported worldwide since the pioneering case performed in France in the year 2005. FAT has received tremendous interest by the medical field and the general public while gaining strong support from multiple disciplines as a solution for reconstructing complex facial defects not amenable/responsive to conventional methods. FAT has expanded the frontiers of reconstructive microsurgery, immunology and transplantation, and established its place in the cross section of multiple disciplines...
February 8, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29399329/intestinal-failure-a-review
#11
REVIEW
Philip Allan, Simon Lal
Intestinal failure (IF) is the inability of the gut to absorb necessary water, macronutrients (carbohydrate, protein, and fat), micronutrients, and electrolytes sufficient to sustain life and requiring intravenous supplementation or replacement. Acute IF (types 1 and 2) is the initial phase of the illness and may last for weeks to a few months, and chronic IF (type 3) from months to years. The challenge of caring for patients with IF is not merely the management of the underlying condition leading to IF or the correct provision of appropriate nutrition or both but also the prevention of complications, whether thromboembolic phenomenon (for example, venous occlusion), central venous catheter-related bloodstream infection, IF-associated liver disease, or metabolic bone disease...
2018: F1000Research
https://www.readbyqxmd.com/read/29396131/donor-pnpla3-rs738409-genotype-is-a-risk-factor-for-graft-steatosis-a-post-transplant-biopsy-based-study
#12
Pavel Trunečka, Irena Míková, Dana Dlouhá, Jaroslav A Hubáček, Eva Honsová, Libor Kolesár, Věra Lánská, Soňa Fraňková, Jan Šperl, Milan Jirsa, Rudolf Poledne
BACKGROUND & AIMS: The rs738409 c.444C > G (p.I148M) polymorphism in PNPLA3 is a major factor predisposing to non-alcoholic fatty liver disease. The aim of the study was to clarify the impact of liver and extrahepatic expression of the PNPLA3 p.148M variant on liver graft steatosis after liver transplantation. METHODS: Fat content was assessed in liver biopsies from 176 transplant recipients. During a period of 4 ± 1 years after transplantation, 17 patients developed grade 3 steatosis, 14 patients grade 2 steatosis, 56 patients grade 1 steatosis, and 89 patients grade 0 steatosis...
January 9, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29371331/hsd17b1-expression-induces-inflammation-aided-rupture-of-mammary-gland-myoepithelium
#13
Päivi Järvensivu, Taija Heinosalo, Janne Hakkarainen, Pauliina Kronqvist, Niina Saarinen, Matti Poutanen
Hydroxysteroid (17-beta) dehydrogenase type 1 (HSD17B1) converts low active estrogen estrone to highly active estradiol. Estradiol is necessary for normal postpubertal mammary gland development; however, elevated estradiol levels increase mammary tumorigenesis. To investigate the significance of the human HSD17B1 enzyme in the mammary gland, transgenic mice universally overexpressing human HSD17B1 were used (HSD17B1TG mice). Mammary glands obtained from HSD17B1TG females at different ages were investigated for morphology and histology, and HSD17B1 activity and estrogen receptor activation in mammary gland tissue were assessed...
January 25, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29371326/leptin-deficient-obesity-prolongs-survival-in-a-murine-model-of-myelodysplastic-syndrome
#14
Michael J Kraakman, Helene L Kammoun, Dragana Dragoljevic, Annas Al-Sharea, Man K S Lee, Michelle C Flynn, Christian J Stolz, Andrew A Guirguis, Graeme I Lancaster, Jaye Chin-Dusting, David J Curtis, Andrew J Murphy
Obesity enhances the risk of developing myelodysplastic syndromes. However, the effect of obesity on survival is unclear. Obese people present with monocytosis due to inflammatory signals emanating from obese adipose tissue. We hypothesized that obesity-induced myelopoiesis would promote the transition of myelodysplastic syndrome to acute myeloid leukemia and accelerate mortality in obesity. Obese Ob/Ob mice or their lean littermate controls received a bone marrow transplant from NUP98-HOXD13 transgenic mice, a model of myelodysplastic syndrome...
January 25, 2018: Haematologica
https://www.readbyqxmd.com/read/29365358/perioperative-loss-of-psoas-muscle-is-associated-with-patient-survival-in-living-donor-liver-transplantation
#15
Min Suk Chae, Kwang Uck Moon, Joon-Yong Jung, Ho Joong Choi, Hyun Sik Jung, Chul Soo Park, Jaemin Lee, Jong Ho Choi, Sang Hyun Hong
BACKGROUND AND AIMS: Patients with end-stage liver disease show sarcopenia, and the preoperative sarcopenia is independently associated with patient mortality after liver transplantation. However, few studies have examined the relationship between perioperative loss of core muscle and patient mortality in living donor liver transplantation (LDLT). This study was performed to investigate the association between a perioperative decrease in the psoas muscle index (PMI) and patient mortality after LDLT...
January 24, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29361369/meloxicam-increases-epidermal-growth-factor-receptor-expression-improving-survival-after-hepatic-resection-in-diet-induced-obese-mice
#16
Xiaoling Jin, Teresa A Zimmers, Yanlin Jiang, Daniel P Milgrom, Zongxiu Zhang, Leonidas G Koniaris
BACKGROUND: Patients with fatty liver have delayed regenerative responses, increased hepatocellular injury, and increased risk for perioperative mortality. Currently, no clinical therapy exists to prevent liver failure or improve regeneration in patients with fatty liver. Previously we demonstrated that obese mice have markedly reduced levels of epidermal growth factor receptor in liver. We sought to identify pharmacologic agents to increase epidermal growth factor receptor expression to improve hepatic regeneration in the setting of fatty liver resection...
January 17, 2018: Surgery
https://www.readbyqxmd.com/read/29356032/non-invasive-quantitative-assessment-of-liver-fat-by-mri-pdff-as-an-endpoint-in-nash-trials
#17
REVIEW
Cyrielle Caussy, Scott B Reeder, Claude B Sirlin, Rohit Loomba
Nonalcoholic fatty liver disease (NAFLD) is now the most common cause of chronic liver disease worldwide, and the progressive form of this condition, nonalcoholic steatohepatitis (NASH), has become one of the leading indications for liver transplant. Despite intensive investigations, there are currently no FDA approved therapies for treating NASH. A major barrier for drug development in NASH is that treatment response assessment continues to require liver biopsy, which is invasive and interpreted subjectively...
January 21, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29352391/functional-recovery-by-application-of-human-dedifferentiated-fat-cells-on-cerebral-infarction-mice-model
#18
Tomoki Kakudo, Naotaka Kishimoto, Tomohiro Matsuyama, Yoshihiro Momota
Elderly people whose daily activities have declined due to a cerebrovascular disorder may suffer from dysphagia and may find oral hygiene difficult. Therefore, it is important to establish an effective therapy for the underlying cerebrovascular disorder. Dedifferentiated fat cells (DFAT) were obtained from mature adipocytes isolated from human buccal adipose pads in a ceiling culture. DFAT expressed the neural markers Nestin and SOX2. Flow cytometric analysis revealed that the cells had properties similar to mesenchymal stem cells...
January 19, 2018: Cytotechnology
https://www.readbyqxmd.com/read/29349819/incidence-and-predictors-of-sudden-cardiac-death-after-heart-transplantation-a-systematic-review-and-meta-analysis
#19
Ana C Alba, Farid Foroutan, Nicholas Kwet Vong Ng Fat Hing, Chun-Po S Fan, Cedric Manlhiot, Heather J Ross
PORPUSE: Sudden cardiac death (SCD) is an important post-transplant problem being responsible for approximately 10% of deaths. We conducted a systematic review and meta-analysis to evaluate incidence and predictors of post-heart transplant SCD, and use of implantable cardiac defibrillator (ICD). METHODS: Citations were identified in electronic databases and references of included studies. Observational studies on adults reporting on incidence and predictors of post-transplant SCD and ICD use were selected...
January 19, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29348470/fibroblast-growth-factor-21-increases-insulin-sensitivity-through-specific-expansion-of-subcutaneous-fat
#20
Huating Li, Guangyu Wu, Qichen Fang, Mingliang Zhang, Xiaoyan Hui, Bin Sheng, Liang Wu, Yuqian Bao, Peng Li, Aimin Xu, Weiping Jia
Although the pharmacological effects of fibroblast growth factor 21 (FGF21) are well-documented, uncertainty about its role in regulating excessive energy intake remains. Here, we show that FGF21 improves systemic insulin sensitivity by promoting the healthy expansion of subcutaneous adipose tissue (SAT). Serum FGF21 levels positively correlate with the SAT area in insulin-sensitive obese individuals. FGF21 knockout mice (FGF21KO) show less SAT mass and are more insulin-resistant when fed a high-fat diet. Replenishment of recombinant FGF21 to a level equivalent to that in obesity restores SAT mass and reverses insulin resistance in FGF21KO, but not in adipose-specific βklotho knockout mice...
January 18, 2018: Nature Communications
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