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https://www.readbyqxmd.com/read/29652075/impact-of-tgf-%C3%AE-family-related-growth-factors-on-chondrogenic-differentiation-of-adipose-derived-stem-cells-isolated-from-lipoaspirates-and-infrapatellar-fat-pads-of-osteoarthritic-patients
#1
E López-Ruiz, G Jiménez, W Kwiatkowski, E Montañez, F Arrebola, E Carrillo, S Choe, J A Marchal, M Perán
The success of cell-based approaches for the treatment of cartilage defects requires an optimal autologous cell source with chondrogenic differentiation ability that maintains its differentiated properties and stability following implantation. The objective of this study was to compare the chondrogenic capacity of mesenchymal stem cells (MSCs) isolated from lipoaspirates (ASCs) and the infrapatellar fat pad (IFPSCs) of osteoarthritic patients and treated with transforming growth factor (TGF)-β family-related growth factors...
April 13, 2018: European Cells & Materials
https://www.readbyqxmd.com/read/29616164/the-impact-of-recipient-site-external-expansion-in-fat-grafting-surgical-outcomes
#2
Carlo M Oranges, Julia Striebel, Mathias Tremp, Srinivas Madduri, Daniel F Kalbermatten, Dirk J Schaefer
Background: The fat grafting process includes the 4 phases of tissue harvesting, processing, recipient-site preparation, and reinjection. Among them, the preparation of the recipient site has never been exhaustively reviewed. We aim to provide a comprehensive overview of the methods to prepare the recipient site through external expansion with the resulting outcomes. Methods: PubMed/Medline database was searched for studies on fat grafting recipient site preparation by applying the following algorithm: ((fat grafting) OR (lipofilling) OR (lipograft) AND (recipient site))...
February 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29609556/the-warburg-effect-in-human-pancreatic-cancer-cells-triggers-cachexia-in-athymic-mice-carrying-the-cancer-cells
#3
Feng Wang, Hongyi Liu, Lijuan Hu, Yunfei Liu, Yijie Duan, Rui Cui, Wencong Tian
BACKGROUND: Cancer cachexia is a cancer-induced metabolic disorder and a major cause of cancer-induced death. The constituents of cancer cachexia include an increase in energy expenditure, hepatic gluconeogenesis, fat lipolysis, and skeletal-muscle proteolysis and a decrease in body weight. The aetiology of cancer cachexia is unclear and may involve cancer-cell metabolism and secretion. In this study, we investigated whether the high glycolysis in cancer cells (the Warburg effect) triggers cachexia in athymic mice carrying pancreatic cancer cells...
April 2, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29605247/breast-reconstruction-after-breast-conservation-therapy-for-breast-cancer
#4
Filip E F Thiessen, Wiebren A A Tjalma, Thierry Tondu
Conservative breast surgery followed by irradiation, often referred to as Breast conserving therapy (BCT), has replaced modified radical mastectomy for the treatment of early stage invasive breast cancer and ductal carcinoma in situ (DCIS). About 10% to 40% of the patients treated with BCT have poor cosmetic outcome results. Small tumours in large breasts can be successfully treated by lumpectomy and radiotherapy, with good cosmetic outcome. However when the tumour breast ratio is higher, the cosmetic outcome can be very disappointing...
March 27, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29599135/par2-protease-activated-receptor-2-deficiency-attenuates-atherosclerosis-in-mice
#5
Shannon M Jones, Adrien Mann, Kelsey Conrad, Keith Saum, David E Hall, Lisa M McKinney, Nathan Robbins, Joel Thompson, Abigail D Peairs, Eric Camerer, Katey J Rayner, Michael Tranter, Nigel Mackman, A Phillip Owens
OBJECTIVE: PAR2 (protease-activated receptor 2)-dependent signaling results in augmented inflammation and has been implicated in the pathogenesis of several autoimmune conditions. The objective of this study was to determine the effect of PAR2 deficiency on the development of atherosclerosis. APPROACH AND RESULTS: PAR2 mRNA and protein expression is increased in human carotid artery and mouse aortic arch atheroma versus control carotid and aortic arch arteries, respectively...
March 29, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29576480/nutritional-support-from-the-intestinal-microbiota-improves-hematopoietic-reconstitution-after-bone-marrow-transplantation-in-mice
#6
Anna Staffas, Marina Burgos da Silva, Ann E Slingerland, Amina Lazrak, Curtis J Bare, Corey D Holman, Melissa D Docampo, Yusuke Shono, Benjamin Durham, Amanda J Pickard, Justin R Cross, Christoph Stein-Thoeringer, Enrico Velardi, Jennifer J Tsai, Lorenz Jahn, Hillary Jay, Sophie Lieberman, Odette M Smith, Eric G Pamer, Jonathan U Peled, David E Cohen, Robert R Jenq, Marcel R M van den Brink
Bone marrow transplantation (BMT) offers curative potential for patients with high-risk hematologic malignancies, but the post-transplantation period is characterized by profound immunodeficiency. Recent studies indicate that the intestinal microbiota not only regulates mucosal immunity, but can also contribute to systemic immunity and hematopoiesis. Using antibiotic-mediated microbiota depletion in a syngeneic BMT mouse model, here we describe a role for the intestinal flora in hematopoietic recovery after BMT...
March 19, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29571958/transplantation-of-dedifferentiated-fat-cell-derived-micromass-pellets-contributed-to-cartilage-repair-in-the-rat-osteochondral-defect-model
#7
Manabu Shimizu, Taro Matsumoto, Shinsuke Kikuta, Munenori Ohtaki, Koichiro Kano, Hiroaki Taniguchi, Shu Saito, Masahiro Nagaoka, Yasuaki Tokuhashi
BACKGROUND: Mature adipocyte-derived dedifferentiated fat (DFAT) cells possesses the ability to proliferate effectively and the potential to differentiate into multiple linages of mesenchymal tissue; similar to adipose-derived stem cells (ASCs). The purpose of this study is to examine the effects of DFAT cell transplantation on cartilage repair in a rat model of osteochondral defects. METHODS: Full-thickness osteochondral defects were created in the knees of Sprague-Dawley rats bilaterally...
March 20, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29568274/transplantation-of-normal-adipose-tissue-improves-blood-flow-and-reduces-inflammation-in-high-fat-fed-mice-with-hindlimb-ischemia
#8
Liyuan Chen, Lin Wang, Yongjie Li, Liqun Wuang, Yaofang Liu, Ningbo Pang, Yulin Luo, Jing He, Liping Zhang, Ni Chen, Rong Li, Jianbo Wu
Background: Fat deposition is associated with peripheral arterial disease. Adipose tissue has recently been implicated in vascular remodeling and angiogenic activity. We hypothesized that the transplantation of adipose tissues from normal mice improves blood flow perfusion and neovascularization in high-fat diet fed mice. Methods: After 14 weeks of high-fat diet (HFD)-fed mice, unilateral hind limb ischemia was performed. Subcutaneous white adipose tissue (WAT) and brown adipose tissue (BAT) fat pads were harvested from normal EGFP mice, and subcutaneously transplanted over the region of the adductor muscles of HFD mice...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29566216/micro-autologous-fat-transplantation-for-treating-a-gummy-smile
#9
Shu-Hung Huang, Yu-Hao Huang, Yun-Nan Lin, Su-Shin Lee, Chih-Kang Chou, Tsung-Ying Lin, Hidenobu Takahashi, Yur-Ren Kuo, Chung-Sheng Lai, Sin-Daw Lin, Tsai-Ming Lin
Background: A gummy smile is treated using a number of techniques, including botulinum toxin injection and various surgical interventions. Micro-autologous fat transplantation (MAFT) is a potentially advantageous alternative approach that has not been previously evaluated. Objective: This study sought to determine the long-term results of MAFT in patients with a gummy smile. Methods: Seven patients with gummy smiles were evaluated for MAFT treatment between October 2015 and April 2017...
March 16, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29565157/-influence-of-liver-transplantation-in-the-nutritional-profile-of-severe-cirrhotic-patients
#10
Caroline Pinho R Andrade, Mileda L T Portugal, Ellén De Sousa Paz, Paula A Freitas, Ana Filomena C S Daltro, Kaluce G S Almondes, Carla Soraya C Maia, Ariclecio Cunha de Oliveira
OBJECTIVE: The aim of this study was to analyze the influence of liver transplantation in food intake and nutritional status of severe cirrhotic patients. METHODS: The sample consisted of 23 patients who underwent liver transplantation. Three 24-hour dietary recall were applied and anthropometric measurements were collected before and three months after transplantation. The consumption of macronutrients and fat soluble vitamins were also evaluated. The anthropometric data evaluated were body mass index, abdominal circumference, percentage of adequacy of arm circumference, triceps skinfold thickness and arm muscle circumference...
January 16, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29560688/prevalence-of-fat-soluble-vitamin-a-d-and-e-and-zinc-deficiency-in-patients-with-cirrhosis-being-assessed-for-liver-transplantation
#11
A Teriaky, M Mosli, N Chandok, B Al-Judaibi, P Marotta, K Qumosani
PURPOSE: To evaluate the prevalence of fat-soluble vitamin (A, D, and E) and zinc deficiency in patients with cirrhosis being assessed for liver transplantation and the correlations between vitamin deficiencies, nutritional markers, and severity of liver disease. METHODS: This is a single centre retrospective study. Serum vitamin A, D, E, and zinc levels were collected in adult patients being assessed for liver transplantation between January and July 2012. Patient and liver disease demographics, nutritional markers, Child-Pugh score, and MELD-Na score were collected...
April 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29559234/body-composition-dietary-intake-and-physical-activity-of-young-survivors-of-childhood-cancer
#12
Alexia J Murphy-Alford, Melinda White, Liane Lockwood, Andrew Hallahan, Peter S W Davies
AIM: To describe the body composition, dietary intake and physical activity and of paediatric, adolescent and young adult childhood cancer survivors (CCS) and examine the factors that impact body composition after treatment. METHODS: This prospective cross-sectional study involved 74 subjects who were at least three years post treatment. Measurements included anthropometry, whole body potassium counting, air displacement plethysmography, and three day physical activity and diet diaries...
March 7, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29556934/a-limited-sampling-strategy-to-estimate-exposure-of-everolimus-in-whole-blood-and-peripheral-blood-mononuclear-cells-in-renal-transplant-recipients-using-population-pharmacokinetic-modeling-and-bayesian-estimators
#13
Ida Robertsen, Jean Debord, Anders Åsberg, Pierre Marquet, Jean-Baptiste Woillard
BACKGROUND AND OBJECTIVE: Intracellular exposure of everolimus may be a better marker of therapeutic effect than trough whole blood concentrations. We aimed to develop pharmacokinetic population models and Bayesian estimators based on a limited sampling strategy for estimation of dose interval exposures of everolimus in whole blood and peripheral blood mononuclear cells (PBMCs) in renal transplant recipients. METHODS: Full whole blood and PBMC concentration-time profiles of everolimus were obtained from 12 stable renal transplant recipients on two different occasions, 4 weeks apart...
March 20, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29554075/ophthalmologic-complications-associated-with-oculofacial-plastic-and-esthetic-surgeries
#14
Ji Sun Baek, Kun Hae Kim, Jung Hye Lee, Hye Sun Choi
PURPOSE: To assess the ophthalmologic complications after oculofacial plastic and esthetic surgeries, including their incidence and management. METHODS: A retrospective study was performed on 110 patients who presented with ocular complications followed by oculofacial plastic and esthetic surgeries from January 2014 to December 2015. The incidence and management of complications after each surgery or procedure were analyzed. RESULTS: For lower eyelid blepharoplasty, the common complications were chemosis and lower eyelid ectropion...
March 16, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29551009/assessment-of-physical-performance-and-body-composition-in-male-renal-transplant-patients
#15
Andrea Petronio Rossi, Gianluigi Zaza, Marina Zanardo, Francesco Pedelini, Laura Dalla Verde, Chiara Caletti, Alessia D'Introno, Antonio Lupo, Mauro Zamboni
BACKGROUND: Renal transplant (RTX) recipients seem to experience a better quality of life compared to dialysis patients. However, the factors responsible for this positive effect are not completely defined. Conceivably, a change in the physical performance of these patients could play a role. METHODS: To assess this, we measured: (1) waist circumference, fat mass and appendicular fat-free mass (aFFM) by dual-energy X-ray densitometry, (2) physical performance with the Short Physical Performance Battery, and (3) muscle strength with the handgrip test, in 59 male RTX, 11 chronic kidney disease in conservative treatment (CKD) and 10 peritoneal dialysis (PD) patients...
March 17, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29550266/fat-bone-interaction-within-the-bone-marrow-milieu-impact-on-hematopoiesis-and-systemic-energy-metabolism
#16
REVIEW
C P Hawkes, S Mostoufi-Moab
The relationship between fat, bone and systemic metabolism is a growing area of scientific interest. Marrow adipose tissue is a well-recognized component of the bone marrow milieu and is metabolically distinct from current established subtypes of adipose tissue. Despite recent advances, the functional significance of marrow adipose tissue is still not clearly delineated. Bone and fat cells share a common mesenchymal stem cell (MSC) within the bone marrow, and hormones and transcription factors such as growth hormone, leptin, and peroxisomal proliferator-activated receptor γ influence MSC differentiation into osteoblasts or adipocytes...
March 14, 2018: Bone
https://www.readbyqxmd.com/read/29549474/contributions-of-magnetic-resonance-imaging-to-gastroenterological-practice-mris-for-gis
#17
REVIEW
Christopher G Roth, Dina Halegoua-De Marzio, Flavius F Guglielmo
MRI has transformed from the theoretical, investigative realm to mainstream clinical medicine over the past four decades and has become a core component of the diagnostic toolbox in the practice of gastroenterology (GI). Its success is attributable to exquisite contrast and the ability to isolate specific proton species through the use of different pulse sequences (i.e., T1-weighted, T2-weighted, diffusion-weighted) and exploiting extracellular and hepatobiliary contrast agents. Consequently, MRI has gained preeminence in various GI clinical applications: liver and pancreatic lesion evaluation and detection, liver transplantation evaluation, pancreatitis evaluation, Crohn's disease evaluation (using MR enterography) rectal cancer staging and perianal fistula evaluation...
March 16, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29528026/aesthetic-surgery-in-transplant-patients-a-single-center-experience
#18
Burak Özkan, Abbas Albayati, Atilla Adnan Eyüboğlu, Ahmet Çağrı Uysal, Nilgun Markal Ertaş, Mehmet Haberal
OBJECTIVES: Transplant patients, like the nontransplant population, can have surgical interventions for body shape disorders. Studies on aesthetic surgeries in transplant patients are scarce. Our aim was to share our experiences with various aesthetic procedures in solid-organ transplant recipients. MATERIALS AND METHODS: Six (5 female, 1 male) transplant patients who received surgical corrections of the aging face, ptosis and lipodystrophy of the breast, and abdomen at the Baskent University Plastic Reconstructive and Aesthetic Surgery Department between 2010 and 2017 were included...
March 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29527997/hand-grip-strength-is-associated-with-serum-testosterone-and-albumin-levels-in-male-kidney-transplant-recipients
#19
Bahar Gürlek Demirci, Siren Sezer, Emre Tutal, Turan Çolak, Saliha Uyanık, Mehmet Haberal
OBJECTIVES: In kidney transplant recipients, reduced muscle mass and hand-grip strength are associated with impaired nutritional status. Serum testosterone is highly associated with muscle strength in the general population. Here, we aimed to determine the associations among serum testosterone, hand-grip strength, and nutritional and inflammatory parameters, as well as graft function. MATERIALS AND METHODS: Our study included 144 stable male kidney transplant recipients from our renal transplant outpatient clinic...
March 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29523181/autologous-chyle-fat-grafting-for-the-treatment-of-hypertrophic-scars-and-scar-related-conditions
#20
Xiao Xu, Linying Lai, Xuyi Zhang, Jinhong Chen, Junnan Chen, Fei Wang, Jingchen Zheng, Minliang Chen
BACKGROUND: Scarring is the product of natural restoration, yet its treatment remains challenging. Both collagen and fibroblasts are abnormally abundant in scars, leading to scar hyperplasia or contracture. Several clinical studies have reported that wrinkles at the recipient site are reduced, pores are narrowed, pigmentation is decreased, and skin is softened after autologous fat transplantation. In this study, we investigated the ability of autologous chyle fat injection to normalize the fibroblasts and collagen of scar tissue in 80 adult patients with hypertrophic scars resulting from severe burns received more than 1 year previously...
March 9, 2018: Stem Cell Research & Therapy
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