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https://www.readbyqxmd.com/read/28776101/molecular-epidemiology-of-multidrug-resistant-clinical-isolates-of-acinetobacter-baumannii-a%C3%A2-10-year-analysis-in-a%C3%A2-large-tertiary-care-university-hospital-in-central-europe-with-international-admissions
#1
Luigi Segagni Lusignani, Peter Starzengruber, Verena Dosch, Ojan Assadian, Elisabeth Presterl, Magda Diab-Elschahawi
BACKGROUND: Over the last 10 years, multidrug resistant Acinetobacter baumannii has been spreading worldwide as emerging microorganisms that negatively impact on the outcome of in-hospital patients. METHODS: Between 2007 and 2016, all isolates of patients of the Vienna General Hospital (VGH), tested positive for multidrug resistant Acinetobacter baumannii (MDR A. baumannii) strains, were investigated with respect to their genetic relationship. Patient medical histories were reviewed in order to collect discriminating factors related to MDR A...
August 3, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28773878/carbon-supported-engineering-nico%C3%A2-o%C3%A2-hybrid-nanofibers-with-enhanced-electrocatalytic-activity-for-oxygen-reduction-reaction
#2
Diab Hassan, Sherif El-Safty, Khalil Abdelrazek Khalil, Montasser Dewidar, Gamal Abu El-Magd
The design of cheap and efficient oxygen reduction reaction (ORR) electrocatalysts is of a significant importance in sustainable and renewable energy technologies. Therefore, ORR catalysts with superb electrocatalytic activity and durability are becoming a necessity but still remain challenging. Herein, we report C/NiCo₂O₄ nanocomposite fibers fabricated by a straightforward electrospinning technique followed by a simple sintering process as a promising ORR electrocatalyst in alkaline condition. The mixed-valence oxide can offer numerous accessible active sites...
September 6, 2016: Materials
https://www.readbyqxmd.com/read/28768639/a-cross-sectional-study-of-the-relationship-between-the-exposure-of-pregnant-women-to-military-attacks-in-2014-in-gaza-and-the-load-of-heavy-metal-contaminants-in-the-hair-of-mothers-and-newborns
#3
Paola Manduca, Safwat Y Diab, Samir R Qouta, Nabil Ma Albarqouni, Raiija-Leena Punamaki
OBJECTIVE: Metal contamination of humans in war areas has rarely been investigated. Weaponry's heavy metals become environmentally stable war remnants and accumulate in living things. They also pose health risks in terms of prenatal intake, with potential long term risks for reproductive and children's health. We studied the contribution of military attacks to the load of 23 metals in the hair of Palestinian women in the Gaza Strip, who were pregnant at the time of the military attacks in 2014, and their newborns...
August 2, 2017: BMJ Open
https://www.readbyqxmd.com/read/28754139/evidence-of-altered-haemostasis-in-an-ovine-model-of-venovenous-extracorporeal-membrane-oxygenation-support
#4
Margaret R Passmore, Yoke L Fung, Gabriela Simonova, Samuel R Foley, Sara D Diab, Kimble R Dunster, Michelle M Spanevello, Charles I McDonald, John-Paul Tung, Natalie M Pecheniuk, Karen Hay, Kiran Shekar, John F Fraser
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) is a life-saving modality used in the management of cardiopulmonary failure that is refractory to conventional medical and surgical therapies. The major problems clinicians face are bleeding and clotting, which can occur simultaneously. To discern the impact of pulmonary injury and ECMO on the host's haemostatic response, we developed an ovine model of smoke-induced acute lung injury (S-ALI) and ECMO. The aims of this study were to determine if the ECMO circuit itself altered haemostasis and if this was augmented in a host with pulmonary injury...
July 29, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28752268/erratum-to-a-new-hereditary-colorectal-cancer-network-in-the-middle-east-and-eastern-mediterranean-countries-to-improve-care-for-high-risk-families
#5
Zeinab Ghorbanoghli, Carol Jabari, Walid Sweidan, Wail Hammoudeh, George Cortas, Ala I Sharara, Amal Abedrabbo, Ijad Hourani, Bahareh Mahjoubi, Keivan Majidzadeh, Nurdan Tözün, Hadia Ziada-Bouchaar, Waseem Hamoudi, Osama Diab, Hamid Reza Khorram Khorshid, Henry Lynch, Hans Vasen
No abstract text is available yet for this article.
July 27, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28750313/imidazo-1-2-a-pyrazine-imidazo-1-5-a-quinoxaline-and%C3%A2-pyrazolo-1-5-a-quinoxaline-derivatives-as-ikk1-and-ikk2-inhibitors
#6
Cindy Patinote, Nour Bou Karroum, Georges Moarbess, Carine Deleuze-Masquefa, Kamel Hadj-Kaddour, Pierre Cuq, Mona Diab-Assaf, Issam Kassab, Pierre-Antoine Bonnet
The transcription nuclear factor NF-κB plays a pivotal role in chronic and acute inflammatory diseases. Among the several and diverse strategies for inhibiting NF-κB, one of the most effective approach considered by the pharmaceutical industry seems to be offered by the development of IKK inhibitors. In a former study, two potential IKK2 inhibitors have been highlighted among a series of imidazo[1,2-a]quinoxaline derivatives. In order to enhance this activity, we present herein the synthesis of twenty-one new compounds based on the imidazo[1,2-a]pyrazine, imidazo[1,5-a]quinoxaline or pyrazolo[1,5-a]quinoxaline structures...
July 19, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28745235/effects-of-ascorbic-acid-on-tax-nf-%C3%AE%C2%BAb-and-mmp-9-in-human-t-cell-lymphotropic-virus-type-1-positive-malignant-t-lymphocytes
#7
Steve Harakeh, Jihane Khalife, Elias Baydoun, Rania Azar, Ahmed Al-Hejin, Elie Barbour, Esam Azhar, Aleksandra Niedzwiecki, Soad Al Jaouni, Mona Diab-Assaf, Mohammad Amjad Kamal, Mathias Rath
BACKGROUND: HTLV-1 is a retrovirus that infects CD4-positive cells and leads to Adult T-cell leukemia by constitutive activation of nuclear factor kappa B. Ascorbic acid (AA) is an essential nutrient that possess anti-proliferative and pro-apoptotic activity against a number of malignant cell lines. This study delineates the effect of AA on Tax protein expression as well as NF-κB and MMP9 activity in two HTLV-1-positive leukemia cells (HuT-102 and C91-PL). METHODS: The cytotoxic and antiproliferative effect of AA were studied by LDH release and MTT tests respectively...
July 25, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28685475/a-new-hereditary-colorectal-cancer-network-in-the-middle-east-and-eastern-mediterranean-countries-to-improve-care-for-high-risk-families
#8
Zeinab Ghorbanoghli, Carol Jabari, Walid Sweidan, Wail Hammoudeh, George Cortas, Ala I Sharara, Amal Abedrabbo, Ijad Hourani, Bahareh Mahjoubi, Keivan Maijdzadeh, Nurdan Tözün, Hadia Ziada-Bouchaar, Waseem Hamoudi, Osama Diab, Hamid Reza Khorram Khorshid, Henry Lynch, Hans Vasen
Colorectal cancer (CRC) has a very high incidence in the western world. Data from registries in the Middle East showed that the incidence of CRC is relatively low in these countries. However, these data also showed that CRC incidence has increased substantially over the past three decades and that a high proportion of cases are diagnosed at an early age (<50 years). In view of these findings, more attention should be paid to prevention. Because of the often limited financial resources, focused screening of individuals with hereditary CRC, in particular those with Lynch syndrome, appears to be the most cost-effective strategy...
July 6, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28681687/retrospective-study-of-fatal-pneumonia-in-racehorses
#9
Francisco R Carvallo, Francisco A Uzal, Santiago S Diab, Ashley E Hill, Rick M Arthur
Respiratory diseases have a major impact on racehorses in training and are often cited as the second most common reason of horses failing to perform. Cases were submitted by the California Horse Racing Board to the California Animal Health and Food Safety laboratory for postmortem examination between January 1, 2005 and December 31, 2014. We determined the demographics of racehorses with fatal pneumonia, characterized the pathologic findings in animals with a postmortem diagnosis of respiratory infection, and determined the most significant pathogens associated with lower respiratory tract disease...
July 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28676244/diagnostic-yield-of-cardiovascular-magnetic-resonance-in-young-middle-aged-patients-with-high-grade-atrio-ventricular-block
#10
A Baritussio, A Ghosh Dastidar, A Frontera, N Ahmed, E De Garate, I Harries, I Diab, E Duncan, G Thomas, A Nisbet, C Bucciarelli-Ducci
BACKGROUND: Atrio-ventricular block (AVB) is a rare finding in young or middle-aged adults, often leading to pacemaker implantation (PM) without further investigation. We sought to assess the diagnostic role of cardiovascular magnetic resonance (CMR) in young and middle-aged adults with high-grade AVB. METHODS: We consecutively enrolled young-middle aged (18-65years) patients with high grade AVB referred to CMR after standard clinical assessment (history, electrocardiogram and cardiac rhythm monitoring) prior to PM implantation...
June 21, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28670915/phytochemical-and-pharmacological-properties-of-essential-oils-from-cedrus-species
#11
Antoine M Saab, Roberto Gambari, Gianni Sacchetti, Alessandra Guerrini, Ilaria Lampronti, Massimo Tacchini, Antoine El Samrani, Samir Medawar, Hassane Makhlouf, Mona Tannoury, Jihad Abboud, Mona Diab-Assaf, Anake Kijjoa, Rosa Tundis, Jawad Aoun, Thomas Efferth
Natural products frequently exert pharmacological activities. The present review gives an overview of the ethnobotany, phytochemistry and pharmacology of the Cedrus genus, e.g. cytotoxic, spasmolytic immunomodulatory, antiallergic, anti-inflammatory and analgesic activities. Cancer patients frequently seek remedies from traditional medicinal plants that are believed to exert less side effects than conventional therapy with synthetic drugs. A long-lasting goal of anti-cancer and anti-microbial therapy research is to find compounds with reduced side effects compared to currently approved drugs...
July 3, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28649381/new-cancer-immunotherapy-agents-in-development-a-report-from-an-associated-program-of-the-31-st-annual-meeting-of-the-society-for-immunotherapy-of-cancer-2016
#12
REVIEW
Prasad S Adusumilli, Edward Cha, Mark Cornfeld, Thomas Davis, Adi Diab, Thomas W Dubensky, Elizabeth Evans, Jane L Grogan, Bryan A Irving, Rom S Leidner, Shane A Olwill, Patrick Soon-Shiong, Frederic Triebel, David Tuck, Adrian Bot, Roger D Dansey, Charles G Drake, Gordon J Freeman, Ramy Ibrahim, Salil Patel, Daniel S Chen
This report is a summary of 'New Cancer Immunotherapy Agents in Development' program, which took place in association with the 31st Annual Meeting of the Society for Immunotherapy of Cancer (SITC), on November 9, 2016 in National Harbor, Maryland. Presenters gave brief overviews of emerging clinical and pre-clinical immune-based agents and combinations, before participating in an extended panel discussion with multidisciplinary leaders, including members of the FDA, leading academic institutions and industrial drug developers, to consider topics relevant to the future of cancer immunotherapy...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28636186/views-of-general-practice-staff-about-the-use-of-a-patient-oriented-treatment-decision-aid-in-shared-decision-making-for-patients-with-type-2-diabetes-a-mixed-methods-study
#13
Anita Wildeboer, Esther du Pon, Jan Schuling, Flora M Haaijer-Ruskamp, Petra Denig
BACKGROUND: Decision aids can be used to support shared decision making (SDM). A patient-oriented treatment decision aid (DA) was developed for type 2 diabetes but its use by general practice staff appeared to be limited. OBJECTIVES: To explore views of practice staff towards SDM and the DA. DESIGN: A mixed-methods study within the Dutch PORTDA-diab trial. SETTING AND PARTICIPANTS: Included were 17 practices with staff members who were responsible for routine diabetes care and had worked with the DA, and 209 of their patients...
June 21, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28631687/-acquired-atresia-and-stenosis-of-the-external-acoustic-meatus
#14
D S Kondratchikov, Kh M Diab, V S Korvyakov, L I Terekhina
Acquired atresia of the external acoustic meatus is a rare pathological condition characterized by obliteration of the medial part of the external acoustic canal by a soft fibrous plug. The present article presents an overview of a series of cases of acquired atresia and stenosis of the external acoustic meatus with the description of etiology, pathogenesis, and methods for the treatment of this condition. In the majority of the cases, atresia develops at the final stage of granulation external otitis with or without an accompanying dermatological pathology...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28627432/high-diversity-of-multidrug-resistant-mycobacterium-tuberculosis-central-asian-strain-isolates-in-nepal
#15
Yogendra Shah, Bhagwan Maharjan, Jeewan Thapa, Ajay Poudel, Hassan Mahmoud Diab, Basu Dev Pandey, Eddie Solo, Norikazu Isoda, Yasuhiko Suzuki, Chie Nakajima
OBJECTIVES: Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) poses a major public health problem in Nepal. Although it has been reported as one of the dominant genotypes of MTB in Nepal, little information on the Central Asian Strain (CAS) family is available, especially isolates related to multidrug resistance (MDR) cases. This study aimed to elucidate the genetic and epidemiological characteristics of MDR CAS isolates in Nepal. METHODS: A total of 145 MDR CAS isolates collected in Nepal from 2008 to 2013 were characterized by spoligotyping, mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) analysis, and drug resistance-associated gene sequencing...
June 13, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28625205/why-suicide-the-analysis-of-motives-for-self-harm
#16
Mohammed J Abbas, Mostafa A Mohanna, Tarig A Diab, Millicent Chikoore, Michael Wang
BACKGROUND: There is a gap in understanding the meaning and motives behind suicidal behaviour. Using the Ideal Type methodology, Jean Baechler systematically examined the internal logic of suicidal and self-harming behaviours. He developed a typology of eleven typical meanings/motives: Flight, Grief, Self-punishment, Vengeance, Crime, Blackmail, Appeal, Sacrifice, Transfiguration, Ordeal and Game. AIMS: To develop and validate a standardized instrument to measure the motives/meanings of suicidal and self-harming behaviours, using Baechler's typology...
June 19, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28619421/the-protective-role-of-maternal-posttraumatic-growth-and-cognitive-trauma-processing-among-palestinian-mothers-and-infants
#17
Safwat Y Diab, Sanna Isosävi, Samir R Qouta, Saija Kuittinen, Raija-Leena Punamäki
War survivors use multiple cognitive and emotional processes to protect their mental health from the negative impacts of trauma. Because mothers and infants may be especially vulnerable to trauma in conditions of war, it is urgent to determine which cognitive and emotional processes are effective for preventing negative trauma impacts." This study examined whether mothers' high posttraumatic growth (PTG) and positive posttraumatic cognitions (PTC) protected (a) their own mental health and (b) their infants' stress regulation and sensorimotor and language development from the effects of war trauma...
June 12, 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/28617886/major-hereditary-gastrointestinal-cancer-syndromes-a-narrative-review
#18
REVIEW
Lakshmi Manogna Chintalacheruvu, Trudy Shaw, Avanija Buddam, Osama Diab, Thamer Kassim, Sandeep Mukherjee, Henry T Lynch
Gastrointestinal cancer is one of the major causes of death worldwide. Hereditary gastrointestinal cancer syndromes constitute about 5-10% of all cancers. About 20-25% of undiagnosed cases have a possible hereditary component, which is not yet established. In the last few decades, the advance in genomics has led to the discovery of multiple cancer predisposition genes in gastrointestinal cancer. Physicians should be aware of these syndromes to identify high-risk patients and offer genetic testing to prevent cancer death...
June 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28608691/impact-of-reabsorption-on-the-emission-spectra-and-recombination-dynamics-of-hybrid-perovskite-single-crystals
#19
Hiba Diab, Christophe Arnold, Ferdinand Lédée, Gaëlle Trippé-Allard, Géraud Delport, Christèle Vilar, Fabien Bretenaker, Julien Barjon, Jean-Sébastien Lauret, Emmanuelle Deleporte, Damien Garrot
Understanding the surface properties of organic-inorganic lead-based perovskites is of high importance to improve the device's performance. Here, we have investigated the differences between surface and bulk optical properties of CH3NH3PbBr3 single crystals. Depth-resolved cathodoluminescence was used to probe the near-surface region on a depth of a few microns. In addition, we have studied the transmitted luminescence through thicknesses between 50 and 600 μm. In both experiments, the expected spectral shift due to the reabsorption effect has been precisely calculated...
June 15, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28584775/evaluation-of-periodontal-status-and-treatment-needs-of-institutionalized-intellectually-disabled-individuals-in-lebanon
#20
Hicham A Diab, Ghassan N Hamadeh, Fouad Ayoub
AIMS AND OBJECTIVES: No reported data is available on the periodontal health and treatment needs of the intellectually disabled in Lebanon. To evaluate the periodontal condition and treatment needs of institutionalized intellectually disabled individuals in Lebanon. MATERIALS AND METHODS: A total of 272 individuals (141 males and 131 females) aged 15 years and 35-44 years were examined. Periodontal health was recorded following the community periodontal index of treatment needs (CPITN), and treatment need was assigned accordingly...
May 2017: Journal of International Society of Preventive & Community Dentistry
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