keyword
MENU ▼
Read by QxMD icon Read
search

Diabes

keyword
https://www.readbyqxmd.com/read/29784675/radiation-followed-by-ox40-stimulation-drives-local-and-abscopal-antitumor-effects-in-an-anti-pd1-resistant-lung-tumor-model
#1
Sharareh Niknam, Hampartsoum B Barsoumian, Jonathan E Schoenhals, Heather Jackson, Niranjan Yanamandra, Mauricio S Caetano, Ailin Li, Ahmed I Younes, Alexandra P Cadena, Taylor R Cushman, Joe Y Chang, Quynh Nguyen, Daniel R Gomez, Adi Diab, John V Heymach, Patrick Hwu, Maria Angelica Cortez, James W Welsh
PURPOSE: Radiation is used extensively to treat localized cancer, but improved understanding of its effects on the immune system have increased interest in its potential systemic (abscopal) effects, particularly in combination with checkpoint inhibitors such as anti-PD1. The majority of patients either do not respond or develop resistance to monotherapy over time. Here, we investigated the efficacy of OX40 (CD134) stimulation as an alternative immunotherapeutic approach in combination with radiotherapy (XRT) in a murine model of anti-PD1-resistant lung tumors...
May 21, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29778019/phoenix-dactylifera-protects-against-oxidative-stress-and-hepatic-injury-induced-by-paracetamol-intoxication-in-rats
#2
Gamal A Salem, Ahmed Shaban, Hussain A Diab, Wesam A Elsaghayer, Manal D Mjedib, Aomassad M Hnesh, Ravi P Sahu
The current studies were sought to determine effects of antioxidant potential of aqueous and methanolic extracts of Phoenix dactylifera leaves (PLAE and PLME) against the widely-used analgesic paracetamol (PCM) induced hepatotoxicity. Groups of rats were treated with or without PCM (1500 mg/kg), PLAE and PLME (300 mg/kg) and n-acetylcysteine (NAC, 50 mg/kg) followed by assessments of liver function tests, oxidative stress, antioxidant defenses, and hepatotoxicity. We observed that PCM significantly elevated serum liver markers, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), and bilirubin compared to control (untreated) group...
May 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29777372/cardiac-surgery-2017-reviewed
#3
REVIEW
Torsten Doenst, Hristo Kirov, Alexandros Moschovas, David Gonzalez-Lopez, Rauf Safarov, Mahmoud Diab, Steffen Bargenda, Gloria Faerber
For the year 2017, more than 21,000 published references can be found in PubMed when entering the search term "cardiac surgery". This review focusses on conventional cardiac surgery, considering the new interventional techniques only if they were directly compared to classic techniques but also entails aspects of perioperative intensive care management. The publications last year provided a plethora of new and interesting information that helped to quantify classic surgical treatment effects and provided new guidelines for the management of structural heart disease, which made comparisons to interventional techniques easier...
May 17, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29774097/natriuretic-peptides-system-in-the-pulmonary-tissue-of-rats-with-heart-failure-potential-involvement-in-lung-edema-and-inflammation
#4
Emad E Khoury, Safa Kinaneh, Doron Aronson, Offer Amir, Diab Ghanim, Natalia Volinsky, Zaher Azzam, Zaid Abassi
Congestive heart failure (CHF) often leads to progressive cardiac hypertrophy and salt/water retention as evident by peripheral and lung edema. Although the pathogenesis of CHF remains largely unclarified, it is widely accepted that neurohormonal changes and inflammatory processes are profoundly involved in structural and functional deterioration of vital organs including, heart, kidney and lungs. Corin, a cardiac serine protease, is responsible for converting pro-ANP and pro-BNP to biologically active natriuretic peptides (NPs)...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29756160/fetal-and-postnatal-echocardiographic-diagnosis-of-ebstein-anomaly-of-the-mitral-valve
#5
Safwat Aly, John Bokowski, Karim Diab, Brie Ann Muller
Ebstein anomaly of mitral valve (MV) is an extremely rare congenital heart disease. In the current report, we present a case of Ebstein of MV that was diagnosed prenatally. Fetal echocardiogram showed that the posterior leaflet of MV was tethered to the lateral wall of left ventricle (LV) with downward displacement into LV cavity. Postnatal transthoracic and transesophageal echocardiograms confirmed the diagnosis with apical displacement of the level of coaptation MV into the LV cavity. To the best of our knowledge, fetal diagnosis of Ebstein anomaly of MV has not yet been reported in the medical literature...
May 14, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29747688/immune-checkpoint-inhibitor-induced-diarrhea-and-colitis-in-patients-with-advanced-malignancies-retrospective-review-at-md-anderson
#6
Yinghong Wang, Hamzah Abu-Sbeih, Emily Mao, Noman Ali, Faisal Shaukat Ali, Wei Qiao, Phillip Lum, Gottumukkala Raju, Gladis Shuttlesworth, John Stroehlein, Adi Diab
BACKGROUND: Immune checkpoint inhibitors (ICPIs) are gaining increasing popularity as an efficacious treatment for advanced malignancies. ICPI treatment can be complicated by diarrhea and colitis. Systemic steroids are the first line treatment. Infliximab is reserved for severe refractory cases. We aimed to assess the impact of ICPI-induced diarrhea and colitis and their immunosuppressive treatment on patients' outcomes. METHODS: This retrospective analysis was conducted in 327 cancer patients who received ICPIs between 2011 and 2017...
May 11, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29733543/disparities-in-breast-cancer-a-multi-institutional-comparative-analysis-focusing-on-american-hispanics
#7
Zeina Nahleh, Salman Otoukesh, Hamid Reza Mirshahidi, Anthony Loc Nguyen, Gayathri Nagaraj, Gehan Botrus, Nabeel Badri, Nabih Diab, Andres Alvarado, Luis A Sanchez, Alok K Dwivedi
Breast cancer (BC) is the leading cause of cancer death in Hispanic/Latino women nationwide. Hispanic women are more likely to be presented with advanced disease and adverse prognosis subtypes. The aim of this study is to describe the clinico- pathological characteristics and disparities in breast cancer in this group at two tertiary care University-based medical centers. After IRB approval, Cancer registry was used to analyze the variables of 3441 patients with breast cancer diagnosed and treated consecutively at two large tertiary University based medical and cancer center database centers in El Paso, TX and Loma Linda, CA between 2005 and 2015...
May 7, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29730369/transcatheter-closure-of-a-sinus-venosus-atrial-septal-defect-via-transhepatic-access
#8
Mohamad Alkhouli, David M Campsey, Luke Higgins, Vinay Badhwar, Anas Diab, Partho P Sengupta
No abstract text is available yet for this article.
April 27, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29718308/endoscopic-and-histologic-features-of-immune-checkpoint-inhibitor-related-colitis
#9
Yinghong Wang, Hamzah Abu-Sbeih, Emily Mao, Noman Ali, Wei Qiao, Van Anh Trinh, Chrystia Zobniw, Daniel Hartman Johnson, Rashmi Samdani, Phillip Lum, Gladis Shuttlesworth, Boris Blechacz, Robert Bresalier, Ethan Miller, Selvi Thirumurthi, David Richards, Gottumukkala Raju, John Stroehlein, Adi Diab
Background: Diarrhea and colitis are the second most common immune checkpoint inhibitor (ICPI)-induced adverse events. However, a comprehensive characterization of the endoscopic and histologic features of ICPI-induced diarrhea and colitis is lacking. Therefore, we aimed to describe endoscopic and histologic features of ICPI-induced gastrointestinal toxicities and to assess their association with patients' clinical characteristics and outcomes. Methods: We retrospectively reviewed records of 53 patients with ICPI-related diarrhea/colitis between 2011 and 2017...
April 27, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29697659/-myoclonus-of-the-middle-ear
#10
Kh M Diab, I V Naumova, O A Balakireva, V N Sokolova, L I Terekhina
The objective of the present study was to overview the foreign literature concerning middle ear myoclonus (MEM) known to be the most common cause of the manifestations of objective tinnitus. The authors reports two typical clinical cases of myoclonus of the middle ear. The present article is aimed at the enhancement of the awareness of the otorhinolaryngologists, audiologists, and neurologists of the condition of interest as a way to promote the further progress in its treatment.
2018: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/29697648/-the-interdisciplinary-approach-to-the-rehabilitation-of-the-patients-presenting-with-congenital-atresia-of-the-external-auditory-canal-and-the-concomitant-microtia
#11
Kh M Diab, D N Nazaryan, N A Daikhes, A E Kharazyan, D S Kondratchikov, S V Yarantsev, O A Pashchinina, M M Cherninkiy
The objective of the present study was to develop and introduce into the clinical practice the method for the combined aesthetic and functional rehabilitation of the patients presenting with congenital atresia of the external auditory canal (CAEAC) and the concomitant microtia. A total of 8 patients at the age from 6 to 21 years with unilateral CAEAC and microtia were given the surgical treatment. During the intervention, atresia was resolved using the trans-mastoid approach, tympanoplasty of autofasciae and ossiculoplasty making use of the partial titanium prosthesis and the placement of cranial osteointegratable titanium implants...
2018: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/29692234/cardiopulmonary-bypass-reduces-early-thrombosis-of-systemic-to-pulmonary-artery-shunts
#12
Jason T Patregnani, Anthony A Sochet, David Zurakowski, Darren Klugman, Yaser Diab, John T Berger, Pranava Sinha
BACKGROUND: Shunt thrombosis is a significant cause of morbidity and mortality after systemic-to-pulmonary artery shunt (SPS) placement. Concurrent procedures with placement of SPS may require cardiopulmonary bypass (CPB). Cardiopulmonary bypass is known to cause bleeding and platelet dysfunction in infants, which may protect from early shunt thrombosis. We hypothesized that infants undergoing SPS placement on CPB have a lower incidence of early shunt thrombosis. METHODS: Retrospective cohort study of infants undergoing SPS placement from January 2008 to December 2014 was performed...
May 2018: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29685478/postprandial-endotoxemia-may-influence-the-development-of-type-2-diabetes-mellitus-from-the-cordioprev-study
#13
Antonio Camargo, Rosa Jimenez-Lucena, Juan F Alcala-Diaz, Oriol A Rangel-Zuñiga, Sonia Garcia-Carpintero, Javier Lopez-Moreno, Ruth Blanco-Rojo, Javier Delgado-Lista, Pablo Perez-Martinez, Ben van Ommen, Maria M Malagon, Jose M Ordovas, Francisco Perez-Jimenez, Jose Lopez-Miranda
BACKGROUND & AIMS: Insulin resistance (IR) and impaired beta-cell function are key determinants of type 2 diabetes mellitus (T2DM). Intestinal absorption of bacterial components activates the toll-like receptors inducing inflammation, and this in turn IR. We evaluated the role of endotoxemia in promoting inflammation-induced insulin resistance (IR) in the development of T2DM, and its usefulness as predictive biomarker. METHODS: We included in this study 462 patients from the CORDIOPREV study without T2DM at baseline...
April 11, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29675680/a-randomized-double-blind-phase-2-study-of-ruxolitinib-or-placebo-in-combination-with-capecitabine-in-patients-with-advanced-her2-negative-breast-cancer-and-elevated-c-reactive-protein-a-marker-of-systemic-inflammation
#14
Joyce O'Shaughnessy, Angela DeMichele, Cynthia X Ma, Paul Richards, Denise A Yardley, Gail Shaw Wright, Kevin Kalinsky, Ronald Steis, Sami Diab, Gerard Kennealey, Ryan Geschwindt, Wei Jiang, Hope S Rugo
PURPOSE: The Janus-associated kinase (JAK)/signal transducer and activator of transcription pathway is a key regulator of inflammatory signaling, associated with tumorigenesis, cell survival, and progression. This randomized phase 2 trial evaluated the efficacy and safety of the addition of ruxolitinib, a JAK1/JAK2 inhibitor, to capecitabine in patients with HER2-negative advanced breast cancer and high systemic inflammation (modified Glasgow Prognostic Score [mGPS] ≥ 1). METHODS: Patients with ≤ 2 prior chemotherapy regimens for advanced or metastatic disease or hormone receptor-positive patients with disease progression on prior hormonal therapies were randomized 1:1 to 21-day cycles of ruxolitinib (n = 76) or placebo (n = 73) plus capecitabine...
April 19, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29672815/minimally-invasive-isolated-tricuspid-valve-redo-surgery-a-safety-and-outcome-analysis
#15
Gloria Färber, Sophie Tkebuchava, Rodolfo Siordia Dawson, Hristo Kirov, Mahmoud Diab, Peter Schlattmann, Torsten Doenst
BACKGROUND:  Isolated tricuspid valve (TV) surgery is considered a high risk-procedure. The optimal surgical approach is controversial. We analyzed our experience with isolated TV redo surgery performed either minimally invasively (redo-MITS) or through sternotomy. METHODS:  We retrospectively analyzed all patients with previous cardiac surgery who underwent redo-MITS ( n  = 26) and compared them to redo-Sternotomy ( n  = 17). A group of primary-MITS ( n  = 61) served as control...
April 19, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29670715/the-effect-of-surface-topographical-changes-of-two-different-surface-treatments-rotary-instrument
#16
Nashwan-Ahmed Qaed, Bilal-Diab Mourshed, Hashem-Motahir Al-Shamiri, Nader Alaizari, Saleh-Sulaiman Alhamdah
Background: One of the major innovations in endodontics has been the introduction of nickel-titanium (NiTi) alloy. This study evaluated the surface topographical changes of two different surface treatments rotary instrument after instrumentation and sterilization. Material and Methods: 240 Extracted teeth were included in this study. 90 new AlphaKite and Revo-S NiTi rotary instruments were selected and divided into two groups (Group A 45 AlphaKite and group B 45 Revo-S)...
January 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29665199/authorship-in-reports-of-clinical-practice-guidelines-a-systematic-cross-sectional-analysis
#17
Mohamed Nomier, Assem M Khamis, Ahmed Ali, Karim N Daou, Aline T Semaan, Maya Diab, Elie A Akl
BACKGROUND: A transparent and explicit reporting on authors' contributions to the development of clinical practice guidelines and on panelists' characteristics is essential for their credibility and trustworthiness. We did not find published studies on authorship or panel involvement in clinical practice guidelines. OBJECTIVE: To describe the approach to authorship in reports of clinical practice guidelines, and the characteristics of individual authors. METHODS: We conducted a cross-sectional survey of guidelines listed in the National Guideline Clearing House (NGC) in 2016...
April 17, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29628414/catheter-related-venous-thrombosis-in-hospitalized-pediatric-patients-with-inflammatory-bowel-disease-incidence-characteristics-and-role-of-anticoagulant-thromboprophylaxis-with-enoxaparin
#18
Carrie E Diamond, Carole Hennessey, Jennifer Meldau, Christine J Guelcher, Michael F Guerrera, Laurie S Conklin, Karun V Sharma, Yaser A Diab
OBJECTIVE: To describe the incidence and characteristics of central venous catheter (CVC)-related thrombosis in hospitalized pediatric patients with active inflammatory bowel disease (IBD) and report the potential usefulness of anticoagulant thromboprophylaxis (AT). STUDY DESIGN: We conducted a retrospective study of patients who were admitted to our children's hospital in the last 2 years with active IBD and required a CVC and identified all patients with an objectively confirmed symptomatic CVC-related thrombosis...
April 5, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29621966/the-epidemiology-of-urinary-tract-infections-in-hiv-positive-patients-at-a-tertiary-care-university-hospital-in-central-europe-2011-2016
#19
Romana Klasinc, Armin Rieger, Elisabeth Presterl, Thomas Wrba, Magda Diab-Elschahawi
OBJECTIVES: There is limited published data concerning recent epidemiology of urinary tract infections (UTI) in HIV-patients, thus we analysed independent risk factors for UTI in HIV positive individuals and antimicrobial resistance rates of E. coli to antimicrobial agents commonly used in UTI. To determine the prevalence of symptomatic urinary tract infections (UTI) in HIV-patients we performed a retrospective case-control study. METHODS: We included 313 HIV-patients, 101 with UTI and 212 age and gender matched controls, attending the HIV outpatient clinic at the Vienna University hospital (VUH) over a period from January 2011 to September 2016...
April 5, 2018: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/29615264/extended-spectrum-beta-lactamase-esbl-and-carbapenemase-producing-enterobacteriaceae-in-water-sources-in-lebanon
#20
Mohamad Diab, Monzer Hamze, Richard Bonnet, Estelle Saras, Jean-Yves Madec, Marisa Haenni
Extended-spectrum beta-lactamases (ESBLs) have been recurrently reported in both human and veterinary medicine, and carbapenemases have also emerged in these two sectors. Such resistance phenotypes were increasingly reported in the environment, which both receives and further disseminates multidrug-resistant (MDR) bacteria. Here, we report the high contamination of water samples (68.2%; 15/22) collected in estuaries in Lebanon. From these 15 contaminated sites, a total of 21 ESBL-producing (mostly harbouring the blaCTX-M-15 gene) and four carbapenemase-producing (two blaOXA-48 and two blaOXA-244 ) Enterobacteriaceae were recovered...
April 2018: Veterinary Microbiology
keyword
keyword
83107
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"