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https://www.readbyqxmd.com/read/28901560/erythema-nodosum-like-panniculitis-mimicking-disease-recurrence-a-novel-toxicity-from-immune-checkpoint-blockade-therapy-report-of-two-patients
#1
Michael T Tetzlaff, Amir A Jazaeri, Carlos A Torres-Cabala, Brinda Rao Korivi, Genie A Landon, Priyadharsini Nagarajan, Adrienne Choksi, Leon Chen, Marc Uemura, Phyu P Aung, Adi Diab, Padmanee Sharma, Michael A Davies, Rodabe Amaria, Victor G Prieto, Jonathan L Curry
Immunotherapies targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and the programmed cell death 1 (PD-1) receptor and its ligand (PD-L1) have demonstrated substantial clinical benefit in patients with clinically advanced solid malignancies. However, autoimmune toxicities are common and often significant adverse events with these agents. While rash and pruritus remain the most common cutaneous complications in treated patients, novel dermatologic toxicities related to immune checkpoint blockade continue to emerge as the number of patients exposed to immunotherapy increases...
September 13, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28901264/inhibition-of-proliferation-and-induction-of-apoptosis-by-thymoquinone-via-modulation-of-tgf-family-p53-p21-and-bcl-2%C3%AE-in-leukemic-cells
#2
Mona Diab Assaf, Josiane Semaan, Marwan El-Sabban, Soad K Al-Jaouni, Rania Azar, Mohammad Amjad Kamal, Steve Harakeh
The rationale of the current study was to investigate whether the inverse association between vitamin D deficiency and parathyroid hormone levels is age-dependent and whether it has any role in modulating renal function and insulin resistance. To test this hypothesis, we have carried out a hospital based study enrolling 848 subjects (558 men and 290 women) with the mean age of 50.9±15.9 y. Vitamin D deficiency was predominant irrespective of age group (p=0.21) and gender (p=0.12). An inverse association between vitamin D and PTH was observed (r= -0...
September 12, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28884798/neonatal-skin-care-what-should-we-do-a-four-week-follow-up-randomized-controlled-trial-at-zagazig-university-hospitals
#3
Mohamed Amer, Nagwa Diab, Mohamed Soliman, Amin Amer
INTRODUCTION: Taking care of newborn skin is necessary to avoid skin infections. The normal daily exposure to external factors affects the skin negatively. Skin hygiene and proper skin cleansing as well as protection of the infant skin barrier are essential to maintain barrier function and overall infant health. AIM: The aim of this work is to assess the neonatal skin care effectiveness in promotion of normal skin development and protection of the optimal skin function by avoiding the different neonatal skin disorders which cause skin infection...
September 7, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28880457/development-of-quality-metrics-for-ambulatory-care-in-pediatric-patients-with-tetralogy-of-fallot
#4
Juan Villafane, Thomas C Edwards, Karim A Diab, Gary M Satou, Elizabeth Saarel, Wyman W Lai, Gerald A Serwer, Peter P Karpawich, Russell Cross, Russell Schiff, Devyani Chowdhury, Thomas J Hougen
OBJECTIVE: The objective of this study was to develop quality metrics (QMs) relating to the ambulatory care of children after complete repair of tetralogy of Fallot (TOF). DESIGN: A workgroup team (WT) of pediatric cardiologists with expertise in all aspects of ambulatory cardiac management was formed at the request of the American College of Cardiology (ACC) and the Adult Congenital and Pediatric Cardiology Council (ACPC), to review published guidelines and consensus data relating to the ambulatory care of repaired TOF patients under the age of 18 years...
September 7, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28878071/zika-virus-escapes-nk-cell-detection-by-upregulating-mhc-class-i-molecules
#5
Ariella Glasner, Esther Oiknine-Djian, Yiska Weisblum, Mohammad Diab, Amos Panet, Dana G Wolf, Ofer Mandelboim
NK cells are innate lymphocytes that participate in many immune processes encompassing cancer, bacterial and fungal infection, autoimmunity and even pregnancy and are specialize in anti-viral defense. NK cells express inhibitory and activating receptors and kill their targets when activating signals overpower the inhibitory ones. The NK cell inhibitory receptors compose of a uniquely diverse array of proteins named Killer-cell immunoglobulin-like receptors (KIRs) the CD94 family and the leukocyte immunoglobulin like receptor family (LIR)...
September 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28872553/hybrid-spect-ct-helps-characterization-and-localization-of-a-dual-thyroid-ectopia
#6
Yasser Abdelhafez, Maha Khalil, Esraa Roshdy, Waleed A Diab, Lobna Eltoni
The presence of ectopic thyroid tissue in 2 or more different sites is rare. A 12-year-old girl presented with midline anterior neck swelling in the infrahyoid region with subclinical hypothyroidism. Thyroid scanning with Tc-pertechnetate was performed, and SPECT/CT was ordered for further evaluation. Two hyperdense lesions demonstrating intense radiotracer uptake were seen in the midline at the base of the tongue and infrahyoid neck. We emphasis the role of hybrid SPECT/CT for characterization and localization of suspected ectopic thyroid tissue...
September 1, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28863357/dual-inhibition-of-mnk2-and-flt3-for-potential-treatment-of-acute-myeloid-leukaemia
#7
Sarah Diab, Ahmad M Abdelaziz, Peng Li, Theodosia Teo, Sunita K C Basnet, Ben Noll, Muhammed H Rahaman, Jingfeng Lu, Jinqiang Hou, Mingfeng Yu, Bich T Le, Hugo Albrecht, Robert W Milne, Shudong Wang
The discovery of novel anti-AML therapeutic agents is urgently needed, but the complex heterogeneity of the disease has so far hampered the development of a curative treatment. FLT3 inhibitors have shown therapeutic potential in clinical trials; but a monotherapy regimen has been associated with resistance mediated by the activation of parallel signalling circuitry, including MAPK and mTOR. Therefore, inhibiting a nexus of the two signalling pathways along with inhibition of FLT3 might be advantageous. Herein, we propose that a dual inhibition of FLT3 and Mnk would provide a better clinical option for AML patients compared to targeting FLT3 alone...
August 3, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28856632/impact-of-perioperative-liver-dysfunction-on-in-hospital-mortality-and-long-term-survival-in-infective-endocarditis-patients
#8
M Diab, C Sponholz, C von Loeffelholz, P Scheffel, M Bauer, A Kortgen, T Lehmann, G Färber, M W Pletz, T Doenst
PURPOSE: Infective endocarditis (IE) is often associated with multiorgan dysfunction and mortality. The impact of perioperative liver dysfunction (LD) on outcome remains unclear and little is known about factors leading to postoperative LD. METHODS: We performed a retrospective, single-center analysis on 285 patients with left-sided IE without pre-existing chronic liver disease referred to our center between 2007 and 2013 for valve surgery. Sequential organ failure assessment (SOFA) score was used to evaluate organ dysfunction...
August 30, 2017: Infection
https://www.readbyqxmd.com/read/28855840/effect-of-gold-nanoparticles-on-mice-splenomegaly-induced-by-schistosomiasis-mansoni
#9
Mohamed A Dkhil, Mona F Khalil, Marwa S M Diab, Amira A Bauomy, Saleh Al-Quraishy
Schistosomiasis is still one of the main parasitic diseases that affect human health in tropical regions. Whilst praziquantel (PZQ) is the main classic antischistosomal drug, the need for new drugs is still a must due to the low effectiveness of the drug on the schistosome young worms, and the evolving of PZQ resistant strains. Nanotechnology is one of the most important recent and current methods used to treat human diseases including parasitic ones. Therefore, the present study aimed to examine the curative role of gold nanoparticles (GNPs) on splenic tissue of mice infected with Schistosoma mansoni Sambon, 1907...
September 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28842624/characterization-and-rnai-mediated-knockdown-of-chitin-synthase-a-in-the-potato-tuber-moth-phthorimaea-operculella
#10
Ahmed M A Mohammed, Mervat R Diab, Mohamed Abdelsattar, Sayed M S Khalil
Chitin is a major component of insect exoskeleton, tracheal system and gut where it is synthesized by chitin synthase (CHS) enzymes. In this paper, we report the isolation and RNAi of chitin synthase A (PhoCHSA) from the potato tuber moth Phthorimaea operculella. The full-length cDNA of PhoCHSA is 5,627 bp with 4,689 bp open reading frame coding for 1,563 amino acids. Structural analysis of conceptual amino acid translation showed three distinct regions found in all known insect CHS proteins; N-terminus region having 9 transmembrane helices, middle catalytic region containing several conserved domains identified in insect CHS enzymes, and C-terminus region containing seven transmembrane spans...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28833322/maternal-trauma-affects-prenatal-mental-health-and-infant-stress-regulation-among-palestinian-dyads
#11
Sanna Isosävi, Safwat Y Diab, Samuli Kangaslampi, Samir Qouta, Saija Kankaanpää, Kaija Puura, Raija-Leena Punamäki
We examined how diverse and cumulated traumatic experiences predicted maternal prenatal mental health and infant stress regulation in war conditions and whether maternal mental health mediated the association between trauma and infant stress regulation. Participants were 511 Palestinian mothers from the Gaza Strip who reported exposure to current war trauma (WT), past childhood emotional (CEA) and physical abuse, socioeconomic status (SES), prenatal mental health problems (posttraumatic stress disorder and depression symptoms), and perceived stress during their secondtrimester of pregnancy as well as infant stress regulation at 4 months...
August 21, 2017: Infant Mental Health Journal
https://www.readbyqxmd.com/read/28830882/successful-treatment-of-arthritis-induced-by-checkpoint-inhibitors-with-tocilizumab-a-case-series
#12
Sang Taek Kim, Jean Tayar, Van Anh Trinh, Maria Suarez-Almazor, Salvador Garcia, Patrick Hwu, Daniel Hartman Johnson, Marc Uemura, Adi Diab
BACKGROUND: Immune checkpoint inhibitors (ICIs) have significantly improved outcomes for patients with numerous cancers. However, these therapies are associated with immune-related adverse events (irAEs), which are inflammatory side effects potentially affecting any organ. Cases of ICI-induced inflammatory arthritis have also been reported. In general, mild irAEs are treated with corticosteroids, while tumour necrosis factor-α (TNFα) inhibitors are reserved for refractory cases. However, prolonged use of TNFα inhibitor (TNFαi) can induce widespread, significant immunosuppression, which can negatively impact the antitumour efficacy of ICI therapy...
August 22, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28819565/genomic-and-immune-heterogeneity-are-associated-with-differential-responses-to-therapy-in-melanoma
#13
Alexandre Reuben, Christine N Spencer, Peter A Prieto, Vancheswaran Gopalakrishnan, Sangeetha M Reddy, John P Miller, Xizeng Mao, Mariana Petaccia De Macedo, Jiong Chen, Xingzhi Song, Hong Jiang, Pei-Ling Chen, Hannah C Beird, Haven R Garber, Whijae Roh, Khalida Wani, Eveline Chen, Cara Haymaker, Marie-Andrée Forget, Latasha D Little, Curtis Gumbs, Rebecca L Thornton, Courtney W Hudgens, Wei-Shen Chen, Jacob Austin-Breneman, Robert Szczepaniak Sloane, Luigi Nezi, Alexandria P Cogdill, Chantale Bernatchez, Jason Roszik, Patrick Hwu, Scott E Woodman, Lynda Chin, Hussein Tawbi, Michael A Davies, Jeffrey E Gershenwald, Rodabe N Amaria, Isabella C Glitza, Adi Diab, Sapna P Patel, Jianhua Hu, Jeffrey E Lee, Elizabeth A Grimm, Michael T Tetzlaff, Alexander J Lazar, Ignacio I Wistuba, Karen Clise-Dwyer, Brett W Carter, Jianhua Zhang, P Andrew Futreal, Padmanee Sharma, James P Allison, Zachary A Cooper, Jennifer A Wargo
Appreciation for genomic and immune heterogeneity in cancer has grown though the relationship of these factors to treatment response has not been thoroughly elucidated. To better understand this, we studied a large cohort of melanoma patients treated with targeted therapy or immune checkpoint blockade (n = 60). Heterogeneity in therapeutic responses via radiologic assessment was observed in the majority of patients. Synchronous melanoma metastases were analyzed via deep genomic and immune profiling, and revealed substantial genomic and immune heterogeneity in all patients studied, with considerable diversity in T cell frequency, and few shared T cell clones (<8% on average) across the cohort...
2017: NPJ Genomic Medicine
https://www.readbyqxmd.com/read/28776101/molecular-epidemiology-of-multidrug-resistant-clinical-isolates-of-acinetobacter-baumannii-a%C3%A2-10-year-analysis-in-a%C3%A2-large-tertiary-care-university-hospital-in-central-europe-with-international-admissions
#14
Luigi Segagni Lusignani, Peter Starzengruber, Verena Dosch, Ojan Assadian, Elisabeth Presterl, Magda Diab-Elschahawi
BACKGROUND: Over the last 10 years, multidrug resistant Acinetobacter baumannii has been spreading worldwide as emerging microorganisms that negatively impact on the outcome of in-hospital patients. METHODS: Between 2007 and 2016, all isolates of patients of the Vienna General Hospital (VGH), tested positive for multidrug resistant Acinetobacter baumannii (MDR A. baumannii) strains, were investigated with respect to their genetic relationship. Patient medical histories were reviewed in order to collect discriminating factors related to MDR A...
August 3, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28773878/carbon-supported-engineering-nico%C3%A2-o%C3%A2-hybrid-nanofibers-with-enhanced-electrocatalytic-activity-for-oxygen-reduction-reaction
#15
Diab Hassan, Sherif El-Safty, Khalil Abdelrazek Khalil, Montasser Dewidar, Gamal Abu El-Magd
The design of cheap and efficient oxygen reduction reaction (ORR) electrocatalysts is of a significant importance in sustainable and renewable energy technologies. Therefore, ORR catalysts with superb electrocatalytic activity and durability are becoming a necessity but still remain challenging. Herein, we report C/NiCo₂O₄ nanocomposite fibers fabricated by a straightforward electrospinning technique followed by a simple sintering process as a promising ORR electrocatalyst in alkaline condition. The mixed-valence oxide can offer numerous accessible active sites...
September 6, 2016: Materials
https://www.readbyqxmd.com/read/28768639/a-cross-sectional-study-of-the-relationship-between-the-exposure-of-pregnant-women-to-military-attacks-in-2014-in-gaza-and-the-load-of-heavy-metal-contaminants-in-the-hair-of-mothers-and-newborns
#16
Paola Manduca, Safwat Y Diab, Samir R Qouta, Nabil Ma Albarqouni, Raiija-Leena Punamaki
OBJECTIVE: Metal contamination of humans in war areas has rarely been investigated. Weaponry's heavy metals become environmentally stable war remnants and accumulate in living things. They also pose health risks in terms of prenatal intake, with potential long term risks for reproductive and children's health. We studied the contribution of military attacks to the load of 23 metals in the hair of Palestinian women in the Gaza Strip, who were pregnant at the time of the military attacks in 2014, and their newborns...
August 2, 2017: BMJ Open
https://www.readbyqxmd.com/read/28754139/evidence-of-altered-haemostasis-in-an-ovine-model-of-venovenous-extracorporeal-membrane-oxygenation-support
#17
Margaret R Passmore, Yoke L Fung, Gabriela Simonova, Samuel R Foley, Sara D Diab, Kimble R Dunster, Michelle M Spanevello, Charles I McDonald, John-Paul Tung, Natalie M Pecheniuk, Karen Hay, Kiran Shekar, John F Fraser
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) is a life-saving modality used in the management of cardiopulmonary failure that is refractory to conventional medical and surgical therapies. The major problems clinicians face are bleeding and clotting, which can occur simultaneously. To discern the impact of pulmonary injury and ECMO on the host's haemostatic response, we developed an ovine model of smoke-induced acute lung injury (S-ALI) and ECMO. The aims of this study were to determine if the ECMO circuit itself altered haemostasis and if this was augmented in a host with pulmonary injury...
July 29, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28752268/erratum-to-a-new-hereditary-colorectal-cancer-network-in-the-middle-east-and-eastern-mediterranean-countries-to-improve-care-for-high-risk-families
#18
Zeinab Ghorbanoghli, Carol Jabari, Walid Sweidan, Wail Hammoudeh, George Cortas, Ala I Sharara, Amal Abedrabbo, Ijad Hourani, Bahareh Mahjoubi, Keivan Majidzadeh, Nurdan Tözün, Hadia Ziada-Bouchaar, Waseem Hamoudi, Osama Diab, Hamid Reza Khorram Khorshid, Henry Lynch, Hans Vasen
No abstract text is available yet for this article.
July 27, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28750313/imidazo-1-2-a-pyrazine-imidazo-1-5-a-quinoxaline-and%C3%A2-pyrazolo-1-5-a-quinoxaline-derivatives-as-ikk1-and-ikk2-inhibitors
#19
Cindy Patinote, Nour Bou Karroum, Georges Moarbess, Carine Deleuze-Masquefa, Kamel Hadj-Kaddour, Pierre Cuq, Mona Diab-Assaf, Issam Kassab, Pierre-Antoine Bonnet
The transcription nuclear factor NF-κB plays a pivotal role in chronic and acute inflammatory diseases. Among the several and diverse strategies for inhibiting NF-κB, one of the most effective approach considered by the pharmaceutical industry seems to be offered by the development of IKK inhibitors. In a former study, two potential IKK2 inhibitors have been highlighted among a series of imidazo[1,2-a]quinoxaline derivatives. In order to enhance this activity, we present herein the synthesis of twenty-one new compounds based on the imidazo[1,2-a]pyrazine, imidazo[1,5-a]quinoxaline or pyrazolo[1,5-a]quinoxaline structures...
July 19, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28745235/effects-of-ascorbic-acid-on-tax-nf-%C3%AE%C2%BAb-and-mmp-9-in-human-t-cell-lymphotropic-virus-type-1-positive-malignant-t-lymphocytes
#20
Steve Harakeh, Jihane Khalife, Elias Baydoun, Rania Azar, Ahmed Al-Hejin, Elie Barbour, Esam Azhar, Aleksandra Niedzwiecki, Soad Al Jaouni, Mona Diab-Assaf, Mohammad Amjad Kamal, Mathias Rath
BACKGROUND: HTLV-1 is a retrovirus that infects CD4-positive cells and leads to Adult T-cell leukemia by constitutive activation of nuclear factor kappa B. Ascorbic acid (AA) is an essential nutrient that possess anti-proliferative and pro-apoptotic activity against a number of malignant cell lines. This study delineates the effect of AA on Tax protein expression as well as NF-κB and MMP9 activity in two HTLV-1-positive leukemia cells (HuT-102 and C91-PL). METHODS: The cytotoxic and antiproliferative effect of AA were studied by LDH release and MTT tests respectively...
July 25, 2017: Anti-cancer Agents in Medicinal Chemistry
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