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https://www.readbyqxmd.com/read/28334367/modeling-of-stiffness-and-strength-of-bone-at-nanoscale
#1
Diab W Abueidda, Fereshteh A Sabet, Iwona M Jasiuk
Two distinct geometrical models of bone at nanoscale (collagen fibril and mineral platelets) are analyzed computationally. In the first model (Model I) minerals are periodically distributed in a staggered manner in a collagen matrix while in the second model (Model II) minerals form continuous layers outside the collagen fibril. Elastic modulus and strength of bone at the nanoscale, represented by these two models, are studied using a finite element software Abaqus. The analysis employs a traction-separation law (cohesive surface modeling) at various interfaces in the models to account for interfacial delaminations...
March 23, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28296662/iv-versus-subcutaneous-enoxaparin-in-critically-ill-infants-and-children-comparison-of-dosing-anticoagulation-quality-efficacy-and-safety-outcomes
#2
Yaser A Diab, Karthik Ramakrishnan, Brandon Ferrell, Reginald Chounoune, Fahad A Alfares, Kendal M Endicott, Sara Rooney, Jason Corcoran, David Zurakowski, John T Berger, Venkat Shankar, Dilip S Nath
OBJECTIVE: Subcutaneous enoxaparin is the mainstay anticoagulant in critically ill pediatric patients although it poses several challenges in this patient population. Enoxaparin infused IV over 30 minutes represents an attractive alternative, but there is limited experience with this route of administration in children. In this study, we assess dosing, anticoagulation quality, safety, and clinical efficacy of IV enoxaparin compared to subcutaneous enoxaparin in critically ill infants and children...
March 14, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28286974/natural-radioactivity-levels-and-associated-health-hazards-from-the-terrestrial-ecosystem-in-rosetta-branch-of-the-river-nile-egypt
#3
W M Abdellah, H M Diab, S U El-Kameesy, E Salama, S El-Framawy
Twenty soil and 25 sediment samples were collected from the banks and bottom of the River Nile in the surroundings of biggest cities located close to it. Natural radioactivity concentrations of (226)Ra, (232)Th and (40)K have been evaluated for all samples by means of γ spectrometric analysis. The radioactivity levels of soil and sediment samples fall within the internationally recommended values. Nevertheless, high natural background radiation zones are detected in the Kafr El-Zayat region due to the presence of a fertilizer factory, and in the Rosetta region due to the presence of black sand deposits...
March 13, 2017: Isotopes in Environmental and Health Studies
https://www.readbyqxmd.com/read/28280348/questionable-accuracy-of-home-blood-pressure-measurements-in-the-obese-population-validation-of-the-microlife-watchbp-o3-%C3%A2-and-omron-rs6-%C3%A2-devices-according-to-the-european-society-of-hypertension-international-protocol
#4
Alaa Azaki, Reem Diab, Aya Harb, Roland Asmar, Mirna N Chahine
OBJECTIVE: Two oscillometric devices, the Microlife WatchBP O3(®) and the Omron RS6(®), designed for self-blood pressure measurement were evaluated according to the European Society of Hypertension (ESH)-International Protocol (IP) Revision 2010 in the obese population. METHODS: The Microlife WatchBP O3 measures blood pressure (BP) at the brachial level and the Omron RS6 measures BP at the wrist level. The ESH-IP revision 2010 includes a total of 33 subjects. The difference between observers' and device BP values was calculated for each measure...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28275515/immediate-versus-delayed-shockwave-lithotripsy-for-inaccessible-stones-after-uncomplicated-percutaneous-nephrolithotomy
#5
Esam A E Desoky, Amr M Fawzi, Ahmed Sakr, Ahmed Eliwa, Ehab R El Sayed, Diab El Sayed, Asharf M S Shahin, Emad A Salem, Hussien M Kamel, Waleed Shabana, Mostafa Kamel
OBJECTIVE: To evaluate the efficacy and safety of immediate versus delayed shockwave lithotripsy (SWL) for inaccessible stones after uncomplicated percutaneous nephrolithotomy (PCNL). PATIENTS AND METHODS: Between December 2011 and June 2014, patients with residual inaccessible stones after uncomplicated PCNL were prospectively randomised into two treatment groups; Group I, immediate SWL and Group II, delayed SWL at 1 week after PCNL. Patients with residual stones of ⩾1...
March 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/28255412/circle-nephrostomy-tube-revisited
#6
Yasser A Noureldin, Christian Diab, David Valenti, Sero Andonian
INTRODUCTION: There are few options for patients requiring chronic urinary drainage using nephrostomy tubes. Although circle nephrostomy tube (CNT) was invented in 1954, it is rarely used. Its advantages include longer indwelling time such that it is changed semi-annually when compared with the standard nephrostomy tube (SNT), which is changed monthly. However, there are no studies comparing indwelling times and costs with these two tubes. The aim of the present study was to compare CNT with SNT in terms of frequency of tube changes, reasons for earlier tube changes, and associated costs...
July 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28251903/integrated-molecular-analysis-of-tumor-biopsies-on-sequential-ctla-4-and-pd-1-blockade-reveals-markers-of-response-and-resistance
#7
Whijae Roh, Pei-Ling Chen, Alexandre Reuben, Christine N Spencer, Peter A Prieto, John P Miller, Vancheswaran Gopalakrishnan, Feng Wang, Zachary A Cooper, Sangeetha M Reddy, Curtis Gumbs, Latasha Little, Qing Chang, Wei-Shen Chen, Khalida Wani, Mariana Petaccia De Macedo, Eveline Chen, Jacob L Austin-Breneman, Hong Jiang, Jason Roszik, Michael T Tetzlaff, Michael A Davies, Jeffrey E Gershenwald, Hussein Tawbi, Alexander J Lazar, Patrick Hwu, Wen-Jen Hwu, Adi Diab, Isabella C Glitza, Sapna P Patel, Scott E Woodman, Rodabe N Amaria, Victor G Prieto, Jianhua Hu, Padmanee Sharma, James P Allison, Lynda Chin, Jianhua Zhang, Jennifer A Wargo, P Andrew Futreal
Immune checkpoint blockade produces clinical benefit in many patients. However, better biomarkers of response are still needed, and mechanisms of resistance remain incompletely understood. To address this, we recently studied a cohort of melanoma patients treated with sequential checkpoint blockade against cytotoxic T lymphocyte antigen-4 (CTLA-4) followed by programmed death receptor-1 (PD-1) and identified immune markers of response and resistance. Building on these studies, we performed deep molecular profiling including T cell receptor sequencing and whole-exome sequencing within the same cohort and demonstrated that a more clonal T cell repertoire was predictive of response to PD-1 but not CTLA-4 blockade...
March 1, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28251726/outcomes-of-algorithm-based-modifications-of-insulinotherapy-during-exercise-in-mdi-vs-insulin-pump-treated-children-with-type-1-diabetes-results-from-the-tread-diab-study
#8
S Moniotte, M Owen, T Barrea, A Robert, P A Lysy
OBJECTIVES: To evaluate the evolution of subcutaneous glucose (SG) after a standardized aerobic exercise in children and adolescents treated with continuous subcutaneous insulin infusion (CSII) or multiple daily injection (MDI) regimen before and after adaptation of insulin doses. RESEARCH DESIGN AND METHODS: Eleven CSII- and 13 MDI-treated patients performed 2 30-minute sessions of moderate to vigorous (70% of age-based maximal heart rate) exercise on a treadmill under continuous glucose monitoring (CGM)...
March 2, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28194715/does-extracellular-dna-production-vary-in-staphylococcal-biofilms-isolated-from-infected-implants-versus-controls
#9
Beata Zatorska, Marion Groger, Doris Moser, Magda Diab-Elschahawi, Luigi Segagni Lusignani, Elisabeth Presterl
BACKGROUND: Prosthetic implant infections caused by Staphylococcus aureus and epidermidis are major challenges for early diagnosis and treatment owing to biofilm formation on the implant surface. Extracellular DNA (eDNA) is actively excreted from bacterial cells in biofilms, contributing to biofilm stability, and may offer promise in the detection or treatment of such infections. QUESTIONS/PURPOSES: (1) Does DNA structure change during biofilm formation? (2) Are there time-dependent differences in eDNA production during biofilm formation? (3) Is there differential eDNA production between clinical and control Staphylococcal isolates? (4) Is eDNA production correlated to biofilm thickness? METHODS: We investigated eDNA presence during biofilm formation in 60 clinical and 30 control isolates of S aureus and S epidermidis...
February 13, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28191644/nk-cell-receptors-nkp46-and-ncr1-control-human-metapneumovirus-infection
#10
Mohammad Diab, Ariella Glasner, Batya Isaacson, Yotam Bar-On, Yaron Drori, Rachel Yamin, Alexandra Duev-Cohen, Oded Danziger, Rachel Zamostiano, Michal Mandelboim, Stipan Jonjic, Eran Bacharach, Ofer Mandelboim
Natural killer (NK) cells are capable of killing various pathogens upon stimulation of activating receptors. Human metapneumovirus (HMPV) is a respiratory virus, which was discovered in 2001 and is responsible for acute respiratory tract infection in infants and children worldwide. HMPV infection is very common, infecting around 70% of all children under the age of five. Under immune suppressive conditions, HMPV infection can be fatal. Not much is known on how NK cells respond to HMPV. In this study, using reporter assays and NK-cell cytotoxicity assays performed with human and mouse NK cells, we demonstrated that the NKp46-activating receptor and its mouse orthologue Ncr1, both members of the natural cytotoxicity receptor (NCR) family, recognized an unknown ligand expressed by HMPV-infected human cells...
February 13, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28183580/effect-of-total-intravenous-vs-volatile-anesthetics-on-intraoperatively-acquired-electrically-evoked-compound-action-potential-in-children-undergoing-cochlear-implant-surgery-a-randomized-prospective-study
#11
Ala A Alhowary, Khaled El-Radaideh, Anas Al-Rusan, Diab Bani Hani, Wail Khraise, Ahmad Al Omari, Firas Alzoubi
OBJECTIVE: The purpose of the present study was to compare the effects of inhalational anesthesia to those of total intravenous anesthesia on intraoperative electrically evoked compound action potential (e-ECAP) thresholds in children undergoing cochlear implantation. STUDY DESIGN: Randomized prospective study. SETTING: Tertiary referral teaching hospital. PATIENTS: Forty children aged 6 months to 17years with bilateral severe-to-profound sensorineural hearing loss and undergoing cochlear implantation were enrolled in the study...
February 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28162459/-225-the-safety-and-efficacy-of-the-trier-social-stress-test-in-individuals-with-fibromyalgia-a-pilot-study
#12
J Kircher, A Pucelli, R Diab, C Ramirez, B Cherry, J Piazza
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28153110/development-of-quality-metrics-in-ambulatory-pediatric-cardiology
#13
REVIEW
Devyani Chowdhury, Michelle Gurvitz, Ariane Marelli, Jeffrey Anderson, Carissa Baker-Smith, Karim A Diab, Thomas C Edwards, Tom Hougen, Roy Jedeikin, Jonathan N Johnson, Peter Karpawich, Wyman Lai, Jimmy C Lu, Stephanie Mitchell, Jane W Newburger, Daniel J Penny, Michael A Portman, Gary Satou, David Teitel, Juan Villafane, Roberta Williams, Kathy Jenkins
The American College of Cardiology Adult Congenital and Pediatric Cardiology (ACPC) Section had attempted to create quality metrics (QM) for ambulatory pediatric practice, but limited evidence made the process difficult. The ACPC sought to develop QMs for ambulatory pediatric cardiology practice. Five areas of interest were identified, and QMs were developed in a 2-step review process. In the first step, an expert panel, using the modified RAND-UCLA methodology, rated each QM for feasibility and validity. The second step sought input from ACPC Section members; final approval was by a vote of the ACPC Council...
February 7, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28152013/using-spatio-temporal-surveillance-data-to-test-the-infectious-environment-of-children-before-type-1-diabetes-diagnosis
#14
Pierre Bougnères, Sophie Le Fur, Sophie Valtat, Yoichiro Kamatani, Mark Lathrop, Alain-Jacques Valleron
The "hygiene hypothesis" postulates that reduced exposure to infections favours the development of autoimmunity and childhood type 1 diabetes (T1D). But on the other side, viruses, notably enteroviruses, are suspected to trigger T1D. The assessment of the possible relationships between infections and T1D still defies the classical tools of epidemiology. We report the methods and results of a geographical approach that maps the addresses of patients to a communicable diseases surveillance database. We mapped the addresses of patients at birth, infancy and T1D diagnosis to the weekly estimates of the regional incidences of 5 frequent communicable diseases routinely collected since 1984 by the French Sentinel network...
2017: PloS One
https://www.readbyqxmd.com/read/28135895/neurologic-complications-in-children-with-scorpionism
#15
Khaled Saad, Mohamed A Abd El-Hamed, Mohamed Gamil M Abo-Elela, Ahmed E Ahmed, Khaled A Abdel-Baseer, Mohamed Diab Aboul-Khair, Kotb Abbass Metwalley, Amira A El-Houfey, Gamal M Hasan, Ahmad M El-Shareef
Scorpion envenomation is a life-threatening health problem in tropical and subtropical regions, particularly among children. The aim of this study was to describe the epidemiologic characteristics, clinical profile, and prognosis of neurologic complications among children with scorpionism in Upper Egypt. In this retrospective study, the neurologic complications of scorpionism in 2 university hospitals were analyzed from the points of epidemiologic and clinical picture and outcomes. The neurologic manifestations were found at a high percentage (85%)...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28134729/lichenoid-dermatologic-toxicity-from-immune-checkpoint-blockade-therapy-a-detailed-examination-of-the-clinicopathologic-features
#16
Michael T Tetzlaff, Priyadharsini Nagarajan, Susan Chon, Auris Huen, Adi Diab, Pacha Omar, Phyu P Aung, Carlos A Torres-Cabala, Steven R Mays, Victor G Prieto, Jonathan L Curry
Immunotherapy targeting the programmed cell death 1 (PD-1) receptor has demonstrated tremendous promise in the treatment of advanced solid tumors. Dermatologic toxicities, however, are an emerging consequence of this therapy and have been clearly associated with immune checkpoint blockade antibodies. Distinctive clinical and histologic subtypes of dermatologic toxicity secondary to immunotherapy are emerging and include rare autoimmune bullous reactions (eg, bullous pemphigoid) and lichenoid eruptions. We report three patients who developed lichenoid dermatitis while receiving anti-PD-1 antibody therapy...
February 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28116090/erratum-to-a-case-report-of-grover-s-disease-from-immunotherapy-a-skin-toxicity-induced-by-inhibition-of-ctla-4-but-not-pd-1
#17
Marc Uemura, Faisal Fa'ak, Cara Haymaker, Natalie McQuail, Elizabeth Sirmans, Courtney W Hudgens, Lydia Barbara, Chantale Bernatchez, Jonathan L Curry, Patrick Hwu, Michael T Tetzlaff, Adi Diab
[This corrects the article DOI: 10.1186/s40425-016-0157-6.].
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28114865/sudden-death-in-racehorses
#18
Santiago S Diab, Robert Poppenga, Francisco A Uzal
In racehorses, sudden death (SD) associated with exercise poses a serious risk to jockeys and adversely affects racehorse welfare and the public perception of horse racing. In a majority of cases of exercise-associated sudden death (EASD), there are no gross lesions to explain the cause of death, and an examination of the cardiovascular system and a toxicologic screen are warranted. Cases of EASD without gross lesions are often presumed to be sudden cardiac deaths (SCD). We describe an equine SD autopsy protocol, with emphasis on histologic examination of the heart ("cardiac histology protocol") and a description of the toxicologic screen performed in racehorses in California...
January 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28101433/use-of-sonic-tomography-to-detect-and-quantify-wood-decay-in-living-trees
#19
Gregory S Gilbert, Javier O Ballesteros, Cesar A Barrios-Rodriguez, Ernesto F Bonadies, Marjorie L Cedeño-Sánchez, Nohely J Fossatti-Caballero, Mariam M Trejos-Rodríguez, José Moises Pérez-Suñiga, Katharine S Holub-Young, Laura A W Henn, Jennifer B Thompson, Cesar G García-López, Amanda C Romo, Daniel C Johnston, Pablo P Barrick, Fulvia A Jordan, Shiran Hershcovich, Natalie Russo, Juan David Sánchez, Juan Pablo Fábrega, Raleigh Lumpkin, Hunter A McWilliams, Kathleen N Chester, Alana C Burgos, E Beatriz Wong, Jonathan H Diab, Sonia A Renteria, Jennifer T Harrower, Douglas A Hooton, Travis C Glenn, Brant C Faircloth, Stephen P Hubbell
PREMISE OF THE STUDY: Field methodology and image analysis protocols using acoustic tomography were developed and evaluated as a tool to estimate the amount of internal decay and damage of living trees, with special attention to tropical rainforest trees with irregular trunk shapes. METHODS AND RESULTS: Living trunks of a diversity of tree species in tropical rainforests in the Republic of Panama were scanned using an Argus Electronic PiCUS 3 Sonic Tomograph and evaluated for the amount and patterns of internal decay...
December 2016: Applications in Plant Sciences
https://www.readbyqxmd.com/read/28095374/human-cytomegalovirus-infection-in-nonimmunocompromised-patients-a-retrospective-analysis-and-review-of-the-literature
#20
REVIEW
Konstantin Zedtwitz-Liebenstein, Magda Diab-Elschahaw, Michael Frass
In a retrospective analysis of patients visiting the Outpatient Department of the Division of Infectious Diseases and Tropical Medicine over a period of 3 years, we found a high incidence of symptomatic nonsevere human cytomegalovirus (HCMV) infection in nonimmunocompromised patients. We present 11 symptomatic cases of HCMV infection in nonimmunocompromised patients with non-life-threatening symptoms like long-lasting depletion, fatigue, and subfebrile fever with or without muscular pain and arthralgia. Although the symptoms were not life-threatening, all of the patients suffered a prolonged duration of the disease until improvement...
2016: Intervirology
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