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https://www.readbyqxmd.com/read/29318557/ear-sponge-assay-a-method-to-investigate-angiogenesis-and-lymphangiogenesis-in-mice
#1
Maureen Van de Velde, Melissa García-Caballero, Tania Durré, Frédéric Kridelka, Agnès Noël
Angiogenesis and lymphangiogenesis have become important research areas in the biomedical field. The outgrowth of new blood (angiogenesis) and lymphatic (lymphangiogenesis) vessels from preexisting ones is involved in many pathologies including cancer. In-depth investigations of molecular determinants such as proteases in these complex processes require reliable in vivo models. Here we present the ear sponge assay as an easy, rapid, quantitative and reproducible model of angiogenesis and lymphangiogenesis. In this system, a gelatin sponge soaked with tumor cells, cell-conditioned medium, or a compound to be tested is implanted, for 2-4 weeks, between the two mouse ear skin layers...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29310798/mechanotransduction-in-blood-and-lymphatic-vascular-development-and-disease
#2
Sofia Urner, Molly Kelly-Goss, Shayn M Peirce, Eckhard Lammert
The blood and lymphatic vasculatures are hierarchical networks of vessels, which constantly transport fluids and, therefore, are exposed to a variety of mechanical forces. Considering the role of mechanotransduction is key for fully understanding how these vascular systems develop, function, and how vascular pathologies evolve. During embryonic development, for example, initiation of blood flow is essential for early vascular remodeling, and increased interstitial fluid pressure as well as initiation of lymph flow is needed for proper development and maturation of the lymphatic vasculature...
2018: Advances in Pharmacology
https://www.readbyqxmd.com/read/29301108/mesenchymal-stromal-cells-inhibit-inflammatory-lymphangiogenesis-in-the-cornea-by-suppressing-macrophage-in-a-tsg-6-dependent-manner
#3
Hyun Beom Song, Se Yeon Park, Jung Hwa Ko, Jong Woo Park, Chang Ho Yoon, Dong Hyun Kim, Jeong Hun Kim, Mee Kum Kim, Ryang Hwa Lee, Darwin J Prockop, Joo Youn Oh
The cornea is a transparent tissue devoid of blood and lymphatic vessels. However, various inflammatory conditions can cause hemangiogenesis and lymphangiogenesis in the cornea, compromising transparency and visual acuity. Mesenchymal stem/stromal cells (MSCs) have therapeutic potentials in a variety of diseases because of anti-inflammatory properties. Herein, we investigated the effects of MSCs on corneal angiogenesis using a model of suture-induced inflammatory corneal neovascularization. Data demonstrated that an intravenous administration of MSCs suppressed corneal inflammation and neovascularization, inhibiting both hemangiogenesis and lymphangiogenesis...
January 3, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29300337/emerging-roles-for-vegf-d-in-human-disease
#4
REVIEW
Steven A Stacker, Marc G Achen
Blood vessels and lymphatic vessels are located in many tissues and organs throughout the body, and play important roles in a wide variety of prevalent diseases in humans. Vascular endothelial growth factor-D (VEGF-D) is a secreted protein that can promote the remodeling of blood vessels and lymphatics in development and disease. Recent fundamental and translational studies have provided insight into the molecular mechanisms by which VEGF-D exerts its effects in human disease. Hence this protein is now of interest as a therapeutic and/or diagnostic target, or as a potential therapeutic agent, in a diversity of indications in cardiovascular medicine, cancer and the devastating pulmonary condition lymphangioleiomyomatosis...
January 4, 2018: Biomolecules
https://www.readbyqxmd.com/read/29284928/molecular-pathogenesis-and-diagnostic-imaging-of-metastatic-jaw-tumors
#5
REVIEW
Kenniyan Kumar Srichinthu, Arjun Parameshwar Raveendran, Periyasamy Tamilthangam, Joseph Joe, Charanya Duraisamy, Thukanayakanpalayam Ragunathan Yoithapprabhunath, Chitturi Ravi Teja
Metastasis is the spread of malignant cells from a primary tumor to distant sites through lymphatics or blood vessels. Malignant lesions metastasizing to the oral and perioral region are a rarity indeed. Malignant lesions could metastasize to both soft tissue of oral cavity and the hard tissues of the jaws and recent meta-analysis showed that metastasis is more common in the jaws than oral soft tissues because of rich vascular supply. The incidence is very low when compared to the incidence of primary oral cancers; nevertheless, one has to include in the diagnostic workup, metastatic malignant lesions, when an irregular ill-defined radiolucency or radiodensity with ragged edges in noted...
November 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29275545/application-of-optical-coherence-tomography-for-in-vivo-monitoring-of-the-meningeal-lymphatic-vessels-during-opening-of-blood-brain-barrier-mechanisms-of-brain-clearing
#6
Oxana Semyachkina-Glushkovskaya, Arkady Abdurashitov, Alexander Dubrovsky, Denis Bragin, Olga Bragina, Nataliya Shushunova, Galina Maslyakova, Nikita Navolokin, Alla Bucharskaya, Valery Tuchin, Juergen Kurths, Alexander Shirokov
The meningeal lymphatic vessels were discovered 2 years ago as the drainage system involved in the mechanisms underlying the clearance of waste products from the brain. The blood-brain barrier (BBB) is a gatekeeper that strongly controls the movement of different molecules from the blood into the brain. We know the scenarios during the opening of the BBB, but there is extremely limited information on how the brain clears the substances that cross the BBB. Here, using the model of sound-induced opening of the BBB, we clearly show how the brain clears dextran after it crosses the BBB via the meningeal lymphatic vessels...
December 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29275449/lymphatic-vessel-involvement-is-predictive-for-lymph-node-metastasis-and-an-important-prognostic-factor-in-endometrial-cancer
#7
Akihiko Wakayama, Wataru Kudaka, Hirofumi Matsumoto, Hajime Aoyama, Takuma Ooyama, Yusuke Taira, Yoshihisa Arakaki, Yuko Shimoji, Tadaharu Nakasone, Kumiko Nishihira, Itomi Kaneshima, Tomoko Tamaki, Naoki Yoshimi, Yoichi Aoki
BACKGROUND: Lymphovascular space involvement is reported to be an important risk factor in endometrial cancer. This study was conducted to evaluate the separate prognostic effects of lymphatic invasion and venous invasion on the outcomes of patients with endometrial cancer. METHODS: From 2006 to 2013, 189 histologically confirmed endometrial cancer patients were examined. To study the venous invasion (v) of the endometrial cancer, Victoria blue-H&E staining-which positively stains the elastic fibers of vessels-was performed...
December 23, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29242199/organ-specific-lymphatic-vasculature-from-development-to-pathophysiology
#8
REVIEW
Tatiana V Petrova, Gou Young Koh
Recent discoveries of novel functions and diverse origins of lymphatic vessels have drastically changed our view of lymphatic vasculature. Traditionally regarded as passive conduits for fluid and immune cells, lymphatic vessels now emerge as active, tissue-specific players in major physiological and pathophysiological processes. Lymphatic vessels show remarkable plasticity and heterogeneity, reflecting their functional specialization to control the tissue microenvironment. Moreover, alternative developmental origins of lymphatic endothelial cells in some organs may contribute to the diversity of their functions in adult tissues...
December 14, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29237738/ascending-vasa-recta-are-angiopoietin-tie2-dependent-lymphatic-like-vessels
#9
Yael Kenig-Kozlovsky, Rizaldy P Scott, Tuncer Onay, Isabel Anna Carota, Benjamin R Thomson, Hyea Jin Gil, Veronica Ramirez, Shinji Yamaguchi, Christine E Tanna, Stefan Heinen, Christine Wu, Radu V Stan, Janet D Klein, Jeff M Sands, Guillermo Oliver, Susan E Quaggin
Urinary concentrating ability is central to mammalian water balance and depends on a medullary osmotic gradient generated by a countercurrent multiplication mechanism. Medullary hyperosmolarity is protected from washout by countercurrent exchange and efficient removal of interstitial fluid resorbed from the loop of Henle and collecting ducts. In most tissues, lymphatic vessels drain excess interstitial fluid back to the venous circulation. However, the renal medulla is devoid of classic lymphatics. Studies have suggested that the fenestrated ascending vasa recta (AVRs) drain the interstitial fluid in this location, but this function has not been conclusively shown...
December 13, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29224892/how-glucose-glutamine-and-fatty-acid-metabolism-shape-blood-and-lymph-vessel-development
#10
REVIEW
Laure-Anne Teuwen, Vincent Geldhof, Peter Carmeliet
Recently, endothelial cell metabolism has emerged as an essential driver and regulator of both blood and lymph vessel development. Evidence rapidly builds that metabolism is not only necessary for endothelial cell function, but moreover controls several aspects of the (lymph)-angiogenic process. So far, the best-characterized metabolic pathways to have an impact on angiogenesis are glycolysis, fatty acid oxidation and glutamine metabolism. Glycolysis regulates tip cell behavior by providing ATP, fatty acid oxidation controls stalk cell proliferation by producing nucleotide biomass, and glutamine metabolism is critical for tip and stalk cell dynamics by supporting Krebs cycle anaplerosis, protein production and redox homeostasis, and links to asparagine metabolism...
December 7, 2017: Developmental Biology
https://www.readbyqxmd.com/read/29213129/deep-tissue-analysis-of-distal-aqueous-drainage-structures-and-contractile-features
#11
Jose M Gonzalez, Minhee K Ko, Young-Kwon Hong, Robert Weigert, James C H Tan
Outflow resistance in the aqueous drainage tract distal to trabecular meshwork is potentially an important determinant of intraocular pressure and success of trabecular bypass glaucoma surgeries. It is unclear how distal resistance is modulated. We sought to establish: (a) multimodal 2-photon deep tissue imaging and 3-dimensional analysis of the distal aqueous drainage tract (DT) in transgenic mice in vivo and ex vivo; (b) criteria for distinguishing the DT from blood and lymphatic vessels; and (c) presence of a DT wall organization capable of contractility...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29209610/perturbation-of-wound-healing-cytoskeletal-organization-and-cellular-protein-networks-during-hazara-virus-infection
#12
Andrea Molinas, Maria V Turkina, Karl-Eric Magnusson, Ali Mirazimi, Elena Vikström
Normal epithelial and endothelial renewal and healing after bacterial and viral challenges are essential for homeostasis along the intestine and the blood and lymphatic vessels. We thus investigated whether and how virus affects migration of human epithelial cells and specifically how the nucleocapsid protein (N) modulates the cellular proteome and interactome using human Caco-2 cells in a wound-healing assay with Hazara virus as a model. Here, Hazara virus blocked cell migration in a dose- and time-dependent manner, disrupted the actin cytoskeleton and specifically reduced the expression of the IQ-motif-containing GTPase-activating protein 1 (IQGAP1) and water channel aquaporin 6 (AQP6) that regulate cytoskeletal organization, water homeostasis and vesicle communication...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29193764/the-interstitium-conducts-extrarenal-storage-of-sodium-and-represents-a-third-compartment-essential-for-extracellular-volume-and-blood-pressure-homeostasis
#13
REVIEW
H Wiig, F C Luft, J M Titze
The role of salt in the pathogenesis of arterial hypertension is not well understood. According to the current understanding, the central mechanism for blood pressure (BP) regulation relies on classical studies linking BP and Na+ balance, placing the kidney at the very centre of long-term BP regulation. To maintain BP homeostasis, the effective circulating fluid volume and thereby body Na+ content has to be maintained within very narrow limits. From recent work in humans and rats, the notion has emerged that Na+ could be stored somewhere in the body without commensurate water retention to buffer free extracellular Na+ and that previously unidentified extrarenal, tissue-specific regulatory mechanisms are operative regulating the release and storage of Na+ from a kidney-independent reservoir...
November 28, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/29157538/mast-cells-in-calcific-aortic-stenosis
#14
Ivo Šteiner, Václav Stejskal, Pavel Žáček
In developed countries, calcific aortic stenosis (CAS) has become the most common acquired valvular disease and reason for aortic valve replacement. It is considered a form of atherosclerosis and, like the latter, of inflammatory origin, with presence in the calcified aortic valves of blood vessels, lymphatics, lymphocytes, plasma cells, histiocytes, and sometimes also of metaplastic bone tissue. This study is aimed at examining the presence of CD117 - positive mast cells in CAS. In 56 examined calcified aortic valves excised by cardiac surgery, mast cells were constantly present as a part of the polymorphous cellular infiltrate; in individual cases, their numbers were 1-90 (median 24)...
July 23, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29145577/photodynamic-therapy-leads-to-time-dependent-regression-of-pathologic-corneal-lymph-angiogenesis-and-promotes-high-risk-corneal-allograft-survival
#15
Yanhong Hou, Viet Nhat Hung Le, Thomas Clahsen, Ann-Charlott Schneider, Felix Bock, Claus Cursiefen
Purpose: Pathologic corneal (lymph) angiogenesis is a known risk factor for immune-mediated allograft rejections after corneal transplantation. However, there is no established treatment to regress pre-existing pathological corneal blood and lymphatic vessels. This study assessed the possibility to regress both vessel types by photodynamic therapy (PDT) after intravenous (i.v.) verteporfin injection, the influence of timing of PDT after verteporfin injection, and the effect on graft survival in high-risk keratoplasty...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29141865/development-and-plasticity-of-meningeal-lymphatic-vessels
#16
Salli Antila, Sinem Karaman, Harri Nurmi, Mikko Airavaara, Merja H Voutilainen, Thomas Mathivet, Dmitri Chilov, Zhilin Li, Tapani Koppinen, Jun-Hee Park, Shentong Fang, Aleksanteri Aspelund, Mart Saarma, Anne Eichmann, Jean-Léon Thomas, Kari Alitalo
The recent discovery of meningeal lymphatic vessels (LVs) has raised interest in their possible involvement in neuropathological processes, yet little is known about their development or maintenance. We show here that meningeal LVs develop postnatally, appearing first around the foramina in the basal parts of the skull and spinal canal, sprouting along the blood vessels and cranial and spinal nerves to various parts of the meninges surrounding the central nervous system (CNS). VEGF-C, expressed mainly in vascular smooth muscle cells, and VEGFR3 in lymphatic endothelial cells were essential for their development, whereas VEGF-D deletion had no effect...
November 15, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29135605/novel-method-to-detect-corneal-lymphatic-vessels-in-vivo-by-intrastromal-injection-of-fluorescein
#17
Viet Nhat Hung Le, Yanhong Hou, Jens Horstmann, Felix Bock, Claus Cursiefen
PURPOSE: Corneal lymphatic vessels are clinically invisible because of their thin walls and clear lymph fluid. There is no easy and established method for in vivo imaging of corneal lymphatic vessels so far. In this study, we present a novel approach to visualize corneal lymphatic vessels in vivo by injecting intrastromal fluorescein sodium. METHODS: Six- to eight-week-old female BALB/c mice were used in the mouse model of suture-induced corneal neovascularization...
November 9, 2017: Cornea
https://www.readbyqxmd.com/read/29133179/stage-related-central-corneal-epithelial-transformation-in-congenital-aniridia-associated-keratopathy
#18
Neil Lagali, Bogumil Wowra, Dariusz Dobrowolski, Tor Paaske Utheim, Per Fagerholm, Edward Wylegala
PURPOSE: To relate central corneal epithelial phenotype to degree of keratopathy in a limbal stem cell deficient population. METHODS: 37 patients (67 eyes) with aniridia-associated keratopathy (AAK) underwent corneal examination including slit lamp biomicroscopy to determine the Grade of AAK, Cochet-Bonnet esthesiometry, and in vivo confocal microscopy (IVCM) to assess morphology of the central corneal epithelium and subepithelial region. RESULTS: AAK Grade ranged from 1 (limbal involvement only) to 4 (total conjunctivalisation), with progression from Grade 1 occurring after the age of 20...
November 10, 2017: Ocular Surface
https://www.readbyqxmd.com/read/29128537/biomaterials-for-articular-cartilage-tissue-engineering-learning-from-biology
#19
REVIEW
A R Armiento, M J Stoddart, M Alini, D Eglin
Articular cartilage is commonly described as a tissue made of up to 80% water, devoid of blood vessels, nerves and lymphatics, and populated by only one cell type: at first glance, an easy tissue for clinicians to repair and for scientists to reproduce in a laboratory. Yet, chondral and osteochondral defects currently remain an open challenge in orthopedics and tissue engineering of the musculoskeletal system, without considering osteoarthritis. Why do we fail in repairing and regenerating articular cartilage? Behind its simple and homogenous appearance articular cartilage hides a heterogeneous composition, a high level of organisation and specific biomechanical properties that taken together make articular cartilage a unique material that we are not able yet to repair or reproduce with high fidelity...
November 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29127332/outflow-of-cerebrospinal-fluid-is-predominantly-through-lymphatic-vessels-and-is-reduced-in-aged-mice
#20
Qiaoli Ma, Benjamin V Ineichen, Michael Detmar, Steven T Proulx
Cerebrospinal fluid (CSF) has been commonly accepted to drain through arachnoid projections from the subarachnoid space to the dural venous sinuses. However, a lymphatic component to CSF outflow has long been known. Here, we utilize lymphatic-reporter mice and high-resolution stereomicroscopy to characterize the anatomical routes and dynamics of outflow of CSF. After infusion into a lateral ventricle, tracers spread into the paravascular spaces of the pia mater and cortex of the brain. Tracers also rapidly reach lymph nodes using perineural routes through foramina in the skull...
November 10, 2017: Nature Communications
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