keyword
MENU ▼
Read by QxMD icon Read
search

blood vessel lymphatic

keyword
https://www.readbyqxmd.com/read/28323646/endothelial-cells-and-lymphatics-at-the-interface-between-the-immune-and-central-nervous-systems-implications-for-multiple-sclerosis
#1
Céline Meyer, Guillaume Martin-Blondel, Roland S Liblau
PURPOSE OF REVIEW: The central nervous system (CNS) has a unique relationship with the immune system. This review highlights the distinct roles of lymphatic vessels and endothelial cells in the interface between CNS and immune cells and invites to revisit the concept of CNS immune privilege. RECENT FINDINGS: T cells can follow several routes to penetrate the CNS parenchyma but may also benefit, together with antigen-loaded presenting cells, from the newly described lymphatic network to exit the CNS...
March 18, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28318074/perforating-and-deep-lymphatic-vessels-in-the-knee-region-an-anatomical-study-and-clinical-implications
#2
Wei-Ren Pan, Fan-Qiang Zeng, De-Guang Wang, Zhi-Qiang Qiu
BACKGROUND: To determine the relationship between the perforating and deep lymphatic vessels in the knee region for clinical implications. METHODS: Four lower limbs from two unembalmed human cadavers were used. Under a surgical microscope, 6% hydrogen peroxide was employed to detect lymph vessels accompanying the small saphenous vein, anterior tibial, posterior tibial and fibular blood vessels all commencing from distal ends of specimens. Each lymphatic vessel was inserted by a 30-gauge needle and injected with a barium sulphate mixture...
March 20, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28301852/high-fat-diet-in-the-absence-of-obesity-does-not-aggravate-surgically-induced-lymphoedema-in-mice
#3
Epameinondas Gousopoulos, Sinem Karaman, Steven T Proulx, Kristin Leu, Dorina Buschle, Michael Detmar
BACKGROUND: Lymphoedema represents the cardinal manifestation of lymphatic dysfunction and is associated with expansion of the adipose tissue in the affected limb. In mice, high-fat diet (HFD)-induced obesity was associated with impaired collecting lymphatic vessel function, and adiposity aggravated surgery-induced lymphoedema in a mouse model. The aim of the current study was to investigate whether adiposity is necessary to impair lymphatic function or whether increased lipid exposure alone might be sufficient in a surgical lymphoedema model...
March 17, 2017: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/28297758/-role-of-master-transcriptional-factor-prox-1-in-lymphatic-endothelial-differentiation-of-kaposiform-hemangioendothelioma
#4
Z Y Ke, S J Yang
Objective: To analyze the clinical and pathological features of Kaposiform hemangioendothelioma (KHE), and to investigate the role of master transcriptional factor Prox-1 in the regulation of lymphatic differentiation. Methods: Nine cases of KHE (during the period from October 2009 to June 2016) were collected with clinical and pathological data. H&E stained section review and immunohistochemietry using the Dako EnVision method were performed. Results: There were 6 female and 3 male patients with age ranging from 2 months to 8 years (median 3 years and 4 months)...
March 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28288772/first-report-of-vascular-invasion-of-demodex-mites-with-thrombi-and-dissemination-to-visceral-lymph-nodes-in-a-dog
#5
Moges Woldemeskel, Ian Hawkins
An adult-onset generalized canine demodecosis is a life threatening form of demodecosis often seen in immunocompromised dogs. A generalized, adult-onset canine demodecosis with an unusual vascular invasion, thrombi and dissemination to peripheral, and visceral lymph nodes was diagnosed in an adult, female, American Bulldog of unknown age. Organized thrombi with intralesional mites were observed in multiple lymphatic vessels and in a section of blood vessel. Vascular invasion of mites with dissemination of mites into visceral lymph nodes, is an unusual findings not previously recorded in canine generalized demodecosis...
March 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28287740/mediating-passive-tumor-accumulation-through-particle-size-tumor-type-and-location
#6
Jillian L Perry, Kevin G Reuter, J Christopher Luft, Chad V Pecot, William C Zamboni, Joseph M DeSimone
As the enhanced permeation and retention (EPR) effect continues to be a controversial topic in nanomedicine, we sought to examine EPR as a function of nanoparticle size, tumor model and tumor location, while also evaluating tumors for EPR mediating factors such as microvessel density, vascular permeability, lymphatics, stromal content, and tumor associated immune cells. Tumor accumulation was evaluated for 55x60 nm, 80x180 nm, and 80x320 nm PRINT particles, in four subcutaneous flank tumor models (SKOV3 human ovarian, 344SQ murine non-small cell lung, A549 human non-small cell lung, and A431 human epidermoid cancer)...
March 13, 2017: Nano Letters
https://www.readbyqxmd.com/read/28287513/an-ex-vivo-method-for-time-lapse-imaging-of-cultured-rat-mesenteric-microvascular-networks
#7
Mohammad S Azimi, Jessica M Motherwell, Walter L Murfee
Angiogenesis, defined as the growth of new blood vessels from pre-existing vessels, involves endothelial cells, pericytes, smooth muscle cells, immune cells, and the coordination with lymphatic vessels and nerves. The multi-cell, multi-system interactions necessitate the investigation of angiogenesis in a physiologically relevant environment. Thus, while the use of in vitro cell-culture models have provided mechanistic insights, a common critique is that they do not recapitulate the complexity associated with a microvascular network...
February 9, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28287124/endogenous-tnf%C3%AE-orchestrates-the-trafficking-of-neutrophils-into-and-within-lymphatic-vessels-during-acute-inflammation
#8
Samantha Arokiasamy, Christian Zakian, Jessica Dilliway, Wen Wang, Sussan Nourshargh, Mathieu-Benoit Voisin
Neutrophils are recognised to play a pivotal role at the interface between innate and acquired immunities following their recruitment to inflamed tissues and lymphoid organs. While neutrophil trafficking through blood vessels has been extensively studied, the molecular mechanisms regulating their migration into the lymphatic system are still poorly understood. Here, we have analysed neutrophil-lymphatic vessel interactions in real time and in vivo using intravital confocal microscopy applied to inflamed cremaster muscles...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28272235/unusual-cause-of-55-years-of-rectal-bleeding-hemolymphangioma-a-case-report
#9
Sagar Pandey, Miao Fan, Junfeng Zhu, Xiaofang Lu, Dandan Chang, Xiuhong Li
RATIONALE: Hemolymphangioma is a rare developmental error of combined blood and lymphatic vasculature. To the best of our knowledge, there is only one case of rectal hemolymphangioma reported in Pubmed. Our case probably is the first reported rectal hemolymphangioma with computed tomography (CT) evaluation. PATIENT CONCERNS AND DIAGNOSIS: A 57-year-old male was presented to our hospital with 55 years of long history of episodic rectal bleeding. Past medical history showed numerous hospital visits for similar illness...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28261938/mast-cell-disorders-in-ehlers-danlos-syndrome
#10
REVIEW
Suranjith L Seneviratne, Anne Maitland, Lawrence Afrin
Well known for their role in allergic disorders, mast cells (MCs) play a key role in homeostatic mechanisms and surveillance, recognizing and responding to different pathogens, and tissue injury, with an array of chemical mediators. After being recruited to connective tissues, resident MCs progenitors undergo further differentiation, under the influence of signals from surrounding microenvironment. It is the differential tissue homing and local maturation factors which result in a diverse population of resident MC phenotypes...
March 6, 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/28259358/prognostic-significance-of-lymphatic-vascular-and-perineural-invasion-for-bladder-cancer-patients-treated-by-radical-cystectomy
#11
Prasuna Muppa, Sounak Gupta, Igor Frank, Stephen A Boorjian, R Jeffrey Karnes, R Houston Thompson, Prabin Thapa, Robert F Tarrell, Loren P Herrera Hernandez, Rafael E Jimenez, John C Cheville
In radical cystectomy specimens with bladder cancer, lymphatic and vascular invasion are often reported as 'angiolymphatic' or 'lymphovascular' invasion, terms that combine the findings of tumour within simple endothelial-lined lymphatic spaces and tumour within muscle-lined blood vessels. It is unclear if these patterns of invasion have different prognostic significance. In addition, there are conflicting data regarding the significance of lymphatic, vascular and perineural invasion in patients with bladder cancer...
March 1, 2017: Pathology
https://www.readbyqxmd.com/read/28253401/netrin-4-mediates-corneal-hemangiogenesis-but-not-lymphangiogenesis-in-the-mouse-model-of-suture-induced-neovascularization
#12
Anna-Karina B Maier, Sabrina Klein, Norbert Kociok, Aline I Riechardt, Enken Gundlach, Nadine Reichhart, Olaf Strauß, Antonia M Joussen
Purpose: Netrin-4, a secreted protein, is found in the basement membrane of blood vessels and acts as a key regulator of angiogenesis. Here we investigated the role of Netrin-4 in the mouse-model of suture-induced corneal hem- and lymphangiogenesis. Methods: Corneal hem- and lymphangiogenesis were induced in Netrin-4-deficient (Ntn4-/-) and wild-type (WT) mice by placing three 11-0 nylon sutures intrastromally. Fourteen days after suturing, the vascularized area was analyzed via corneal flat mount immunohistochemistry...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28248931/systematic-high-content-genome-wide-rnai-screens-of-endothelial-cell-migration-and-morphology
#13
Steven P Williams, Cathryn M Gould, Cameron J Nowell, Tara Karnezis, Marc G Achen, Kaylene J Simpson, Steven A Stacker
Many cell types undergo migration during embryogenesis and disease. Endothelial cells line blood vessels and lymphatics, which migrate during development as part of angiogenesis, lymphangiogenesis and other types of vessel remodelling. These processes are also important in wound healing, cancer metastasis and cardiovascular conditions. However, the molecular control of endothelial cell migration is poorly understood. Here, we present a dataset containing siRNA screens that identify known and novel components of signalling pathways regulating migration of lymphatic endothelial cells...
March 1, 2017: Scientific Data
https://www.readbyqxmd.com/read/28248032/-the-risk-of-bladder-cancer-in-patients-with-prostatic-hyperplasia-and-strategies-to-manage-this-combination
#14
Yu G Alyaev, A M Pshikhachev, A N Perekalina
The combination of bladder cancer with benign prostatic hyperplasia (BPH) occurs in 5-27% of cases. The link between these diseases has not yet been closely investigated. The main role in the pathogenesis of bladder cancer combined with BPH is played by the residual urine and prolonged exposure of urothelium to the urine carcinogens. The choice of surgical treatment modality for the combination of non-muscle invasive bladder cancer and BPH is still a matter of debate. There is no consensus on the safety and appropriateness of simultaneous transurethral resection of the bladder and prostate in these patients...
November 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28238775/assessing-the-brain-through-the-eye-new-ways-to-explore-hepatic-encephalopathy
#15
Natalia Arias, Marta Méndez, Ignacio Alcalde, Almudena Íñigo-Portugués, Jesús Merayo-Lloves, Jaime Arias, Jorge L Arias
BACKGROUND & AIMS: Minimal hepatic encephalopathy (mHE) has been shown to affect daily functioning, quality of life, driving and overall mortality. However, little is known about treating or diagnosing early impairments in mHE. We studied one of its precipitating factors, portal hypertension which is driving the inflammatory process behind mHE. The purpose was to describe an indirect diagnostic method able to detect the pathology at early stages based on the study of the vascularization and mast cells conjunctival hyperplasia as secondary inflammatory response associated to portal hypertension...
February 24, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28237707/study-of-fluid-dynamics-reveals-direct-communications-between-lymphatic-vessels-and-venous-blood-vessels-at-lymph-nodes-of-mice
#16
Kazu Takeda, Shiro Mori, Tetsuya Kodama
Cancer cells metastasize to lymph nodes, with distant metastasis resulting in poor prognosis. The role of lymph node metastasis (LNM) in the spread of cancer to distant organs remain incompletely characterized. The visualization of flow dynamics in the lymphatic and blood vessels of MXH10/Mo-lpr/lpr mice, which develop systemic swelling of lymph nodes up to 10mm in diameter, has revealed that lymph nodes have the potential to be a direct source of systemic metastasis. However, it is not known whether these fluid dynamics characteristics are universal phenomena present in other strains of laboratory mice...
February 22, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28228406/renal-inflammation-and-injury-is-associated-with-lymphangiogenesis-in-hypertension
#17
Sterling C Kneedler, Lauren E Phillips, Kayla R Hudson, Katharine M Beckman, Catalina A Lopez Gelston, Joseph M Rutkowski, Alan R Parrish, Peter A Doris, Brett M Mitchell
Lymphatic vessels are vital for the trafficking of immune cells from the interstitium to draining lymph nodes during inflammation. Hypertension is associated with renal infiltration of activated immune cells and inflammation, however it is unknown how renal lymphatic vessels change in hypertension. We hypothesized that renal macrophage infiltration and inflammation would cause increased lymphatic vessel density in hypertensive rats. Spontaneously hypertensive rats (SHR) that exhibit hypertension and renal injury (SHR-A3 strain) had significantly increased renal lymphatic vessel density and macrophages at 40 weeks of age compared to Wistar-Kyoto (WKY) controls...
February 22, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28220247/myeloid-cells-pave-the-way-for-lymphatic-system-development-and-maintenance
#18
REVIEW
Stoyan Ivanov, Gwendalyn J Randolph
The maintenance of tissue homeostasis is indispensable for health. In particular, removal of toxic compounds from cells and organs is a vital process for the organism. The lymphatic vasculature works in order to ensure the efficient removal of tissue waste. Forbidden over the last decade when more attention was paid to the blood vasculature, studies on the lymphatic vasculature have gained momentum during the last couple of years. The lymphatic vasculature naturally runs parallel to the blood vasculature and their synergistic work is critical for maintaining tissue homeostasis...
February 20, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28217128/tumor-associated-lymphatic-vessels-upregulate-pdl1-to-inhibit-t-cell-activation
#19
Lothar C Dieterich, Kristian Ikenberg, Timur Cetintas, Kübra Kapaklikaya, Cornelia Hutmacher, Michael Detmar
Tumor-associated lymphatic vessels (LVs) play multiple roles during tumor progression, including promotion of metastasis and regulation of antitumor immune responses by delivering antigen from the tumor bed to draining lymph nodes (LNs). Under steady-state conditions, LN resident lymphatic endothelial cells (LECs) have been found to maintain peripheral tolerance by directly inhibiting autoreactive T-cells. Similarly, tumor-associated lymphatic endothelium has been suggested to reduce antitumor T-cell responses, but the mechanisms that mediate this effect have not been clarified...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28211204/evaluation-of-the-enhanced-permeability-and-retention-effect-in-the-early-stages-of-lymph-node-metastasis
#20
Mamoru Mikada, Ariunbuyan Sukhbaatar, Yoshinobu Miura, Sachiko Horie, Maya Sakamoto, Shiro Mori, Tetsuya Kodama
Most solid cancers spread to new sites via the lymphatics before hematogenous dissemination. However, only a small fraction of an intravenously administered anti-cancer drug enters the lymphatic system to reach metastatic lymph nodes (LNs). Here, we show that the enhanced permeability and retention (EPR) effect is not induced during the early stages of LN metastasis. Luciferase-expressing tumor cells were injected into the subiliac LN of the MXH10/Mo-lpr/lpr mouse to induce metastasis to the proper axillary LN (PALN)...
February 17, 2017: Cancer Science
keyword
keyword
83100
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"