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Mixed connective tissue disease

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https://www.readbyqxmd.com/read/27900293/combined-use-of-platelet-rich-plasma-micro-fat-in-sport-and-race-horses-with-degenerative-joint-disease-preliminary-clinical-study-in-eight-horses
#1
Fabrizio Bembo, Julia Eraud, Cecile Philandrianos, Baptiste Bertrand, Alain Silvestre, Julie Veran, Florence Sabatier, Guy Magalon, Jeremy Magalon
BACKGROUND: To assess the safety and potential efficacy of a standardized technique consisting of intra-articular injection of 10 cc of a homogeneous mixed product using autologous micro-fat and platelet rich plasma (PRP) (ratio 1:1) in the carpus or the fetlock joint of sport horses presenting degenerative joint disease (DJD). METHODS: Eight sport horses with DJD confirmed by radiography and ultrasonography and causing lameness and the impossibility to compete were treated...
April 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/27888985/azathioprine-response-in-patients-with-fibrotic-connective-tissue-disease-associated-interstitial-lung-disease
#2
Justin M Oldham, Cathryn Lee, Eleanor Valenzi, Leah J Witt, Ayodeji Adegunsoye, Scully Hsu, Lena Chen, Steven Montner, Jonathan H Chung, Imre Noth, Rekha Vij, Mary E Strek
BACKGROUND: Azathioprine is a commonly prescribed therapy for connective tissue disease-associated interstitial lung disease (CTD-ILD). Combination therapy that included azathioprine was recently shown to increase the risk of death and hospitalization in patients with idiopathic pulmonary fibrosis. Whether azathioprine increases the risk of adverse outcomes in patients with fibrotic CTD-ILD, including those with CTD-associated usual interstitial pneumonia (UIP), remains unknown. METHODS: A retrospective cohort analysis was performed to determine the combined incidence rate of death, transplant and respiratory hospitalization associated with azathioprine exposure...
December 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27870974/myocardial-perfusion-in-peripheral-raynaud-s-phenomenon-evaluation-using-stress-cardiovascular-magnetic-resonance
#3
Sophie Mavrogeni, Konstantinos Bratis, Loukia Koutsogeorgopoulou, Georgia Karabela, Efthymios Savropoulos, Gikas Katsifis, John Raftakis, George Markousis-Mavrogenis, Genovefa Kolovou
BACKGROUND: Peripheral Raynaud's phenomenon (RP) is either primary (PRP), without any coexisting disease or secondary (SRP), due to connective tissue diseases (CTD). We hypothesized that adenosine stress cardiovascular magnetic resonance (CMR) can assess myocardial perfusion in a population of PRP and SRP. PATIENTS-METHODS: Twenty CTDs, aged 30.6±7.5yrs., 16F/4M, including 9 systemic sclerosis (SSc), 4 systemic lupus erythematosus (SLE), 3 mixed connective tissue disease (MCTD), 2 polymyositis (PM) and 2 rheumatoid arthritis (RA), with SRP, under treatment with calcium blockers, were evaluated by stress CMR and compared with age-sex matched PRP and controls...
November 12, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27826173/immunity-and-early-atherosclerosis-in-the-course-of-systemic-lupus-erythematosus-mixed-connective-tissue-disease-and-antiphospholipid-syndrome
#4
REVIEW
Ewa Haładyj, Agnieszka Paradowska-Gorycka, Anna Felis-Giemza, Marzena Olesińska
Atherosclerosis is a chronic inflammatory disease of the arteries associated with various risk factors that promote lipid abnormalities, development and progression of atherosclerotic lesions, plaque rupture, and vascular thrombosis. Atherosclerosis is accelerated in autoimmune diseases. Non-invasive investigations showed increased intima-media thickness (IMT), carotid plaque, and coronary artery calcifications in patients with antiphospholipid syndrome, systemic lupus erythematosus and mixed connective tissue disease compared to controls...
2016: Reumatologia
https://www.readbyqxmd.com/read/27799164/how-i-treat-cryoglobulinemia
#5
Eli Muchtar, Hila Magen, Morie A Gertz
Cryoglobulinemia is a distinct entity catheterized by the presence of cryoglobulins in the serum. Cryoglobulins differ in their composition, which has an impact on the clinical presentation and the underlying disease triggering cryoglobulin formation. Cryoglobulinemia is categorized into two main subgroups: Type I seen exclusively in clonal hematological diseases, and mixed cryoglobulinemia (type II/III) seen in HCV infection and systemic diseases such as B-cell lineage hematological malignancies and connective tissue disorders...
October 31, 2016: Blood
https://www.readbyqxmd.com/read/27788293/prevalence-of-mixed-connective-tissue-disease-in-a-population-based-registry-of-american-indian-alaska-native-people-in-2007
#6
Elizabeth D Ferucci, Janet M Johnston, Caroline Gordon, Charles G Helmick, S Sam Lim
OBJECTIVE: The objective of this surveillance project was to determine the prevalence of mixed connective tissue disease (MCTD) in 2007 in the Indian Health Service (IHS) active clinical population from 3 regions of the United States. METHODS: The IHS Lupus Registry was designed to identify possible MCTD cases in addition to lupus. The population denominator for this report includes American Indian or Alaska Native adults within the IHS active clinical population in 2007, residing in select communities in 3 regions of the US...
October 27, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27776552/scleroderma-and-dentistry-two-case-reports
#7
Shantanu Dixit, Chaithra Kalkur, Atul P Sattur, Michael M Bornstein, Fred Melton
BACKGROUND: Scleroderma is a chronic connective tissue disorder with unknown etiology. It is characterized by excessive deposition of extracellular matrix in the connective tissues causing vascular disturbances which can result in tissue hypoxia. These changes are manifested as atrophy of the skin and/or mucosa, subcutaneous tissue, muscles, and internal organs. Such changes can be classified into two types, namely, morphea (localized) and diffuse (systemic). Morphea can manifest itself as hemifacial atrophy (Parry-Romberg syndrome) although this remains debatable...
October 24, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27749242/effects-of-rituximab-in-connective-tissue-disorders-related-interstitial-lung-disease
#8
Gemma Lepri, Jerome Avouac, Paolo Airò, Francisco Anguita Santos, Silvia Bellando-Randone, Jelena Blagojevic, Francisco Garcia Hernàndez, Jose Antonio Gonzalez Nieto, Serena Guiducci, Suzana Jordan, Vidya Limaye, Britta Maurer, Albert Selva-O'Callaghan, Valeria Riccieri, Oliver Distler, Marco Matucci-Cerinic, Yannick Allanore
OBJECTIVES: Interstitial lung disease (ILD) is a key prognostic factor in connective tissue disorders (CTDs). The aim of our study was to assess the changes in pulmonary functional tests (PFTs) in various CTDs, including anti-synthetase syndrome (SYN), systemic sclerosis (SSc) and mixed connective tissue disorder (MCTD), following the use of rituximab therapy. METHODS: A multicentre retrospective analysis of patients with ILD secondary to SYN (n=15), MCTD (n=6) and SSc (n=23)...
September 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27738519/tocilizumab-in-the-treatment-of-mixed-connective-tissue-disease-and-overlap-syndrome-in-children
#9
Natalia Cabrera, Agnes Duquesne, Marine Desjonquères, Jean-Paul Larbre, Jean-Christophe Lega, Nicole Fabien, Alexandre Belot
Arthritis is one of the main manifestations of mixed connective tissue disease (MCTD) and overlap syndrome in children and can be responsible for functional disability. We report on 2 children with arthritis that were dramatically improved by a treatment with interleukin-6 (IL-6) blockers in the context of connective tissue disease. However, in both cases, other systemic autoimmune symptoms were not modified by the treatment and autoantibodies tend to increase, suggesting a differential effect of IL-6 inhibition on articular inflammation and systemic autoimmunity...
2016: RMD Open
https://www.readbyqxmd.com/read/27728674/a-case-of-mixed-connective-tissue-disease
#10
Aasritha Mekala, Y S Sarma, S V Ramana Murthy
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27728662/a-rare-case-of-wilsons-disease-carrier-with-mixed-connective-tissue-disorder
#11
P Lakshmi Raghavendra, Uma Ma, Srinivasa Rao, Yjv Reddy
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27719973/imaging-of-pulmonary-manifestations-of-connective-tissue-diseases
#12
Jitesh Ahuja, Deepika Arora, Jeffrey P Kanne, Travis S Henry, J David Godwin
Connective tissue diseases (CTDs) are a heterogeneous group of conditions characterized by circulating autoantibodies and autoimmune-mediated organ damage. Common CTDs with lung manifestations are rheumatoid arthritis, scleroderma or systemic sclerosis, Sjögren syndrome, polymyositis/dermatomyositis, systemic lupus erythematosis, mixed connective tissue disease, and undifferentiated connective tissue disease. The most common histopathologic patterns of CTD-related interstitial lung disease are nonspecific interstitial pneumonia, usual interstitial pneumonia, organizing pneumonia, and lymphoid interstitial pneumonia...
November 2016: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/27694069/mixed-connective-tissue-disease-with-bilateral-erythematous-palpebral-oedema-and-targetoid-skin-lesions
#13
Masanobu Sakaguchi, Tomoki Takeda, Takao Kodera, Kazuhiro Murakami, Masahiro Oka
No abstract text is available yet for this article.
September 29, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27618831/clinical-association-of-mixed-connective-tissue-disease-and-granulomatosis-with-polyangiitis-a-case-report-and-systematic-screening-of-anti-u1rnp-and-anti-pr3-auto-antibody-double-positivity-in-ten-european-hospitals
#14
Amandine Tubery, Françoise Fortenfant, Bernard Combe, Isabelle Abreu, Xavier Bossuyt, Pascale Chretien, Sophie Desplat-Jégo, Nicole Fabien, Sophie Hue, Catherine Johanet, Daniela Lakomy, Thierry Vincent, Claire I Daïen
We report here the case of a 50-years-old man treated for mixed connective tissue disease (MCTD) positive for anti-U1 ribonucleoprotein (U1RNP) antibodies who secondarily developed a granulomatosis with polyangiitis (GPA) associated with anti-proteinase 3 anti-neutrophil cytoplasmic antibodies (PR3-ANCA). We then evaluated the frequency of the association between anti-U1RNP and anti-PR3-ANCA antibodies by a systematic retrospective study in ten European hospitals. Overall, out of 11,921 samples analyzed for both auto-antibodies, 18 cases of anti-U1RNP and anti-PR3-ANCA double positivity were found and only one patient presented with both MCTD and GPA symptoms...
September 12, 2016: Immunologic Research
https://www.readbyqxmd.com/read/27598847/ophthalmic-manifestations-in-chronic-inflammatory-rheumatic-diseases-at-a-referral-hospital-of-yaounde-cameroon
#15
Christelle Domngang Noche, Giles Kagmeni, Viola Dohvoma, Assumpta Lucienne Bella, Come Ebana Mvogo, Madeleine Singwe-Ngandeu
PURPOSE: To determine the profile of ophthalmic manifestations in chronic inflammatory rheumatic diseases (CIRD). METHODS: Observational study at the Yaounde Central Hospital and Innel Medical Centre (2004 to 2012). RESULTS: The study population (n = 36) consisted of 14 men and 22 women with average age of 47.9 ± 17.2 years. Cases of CIRD were rheumatoid arthritis (n = 16), systemic lupus erythematosus (n = 8), ankylosing spondylitis (n = 8), mixed connective tissue disease (n = 2), scleroderma (n = 1), and juvenile idiopathic arthritis (n = 1)...
September 6, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27586323/-intractable-myasthenia-gravis-accompanied-with-thymoma-report-of-a-case
#16
Akira Naomi, Yoshinori Oyamatsu, Kunio Narita, Masato Nakayama, Shoki Maeda
A 46-year-old female visited a hospital due to pelvic inflammatory disease (PID) and then her chest computed tomography revealed an abnormal shadow in the upper mediastinum. Four months later,she complained muscle weakness with her limbs, dysphagia, and ptosis of her eyelids. Total thymectomy was performed through a median sternotomy for mass lesion, which was pathologically proven to be type B1 thymoma. Postoperative myasthenia gravis (MG) crisis, which led to respiratory failure requiring intubation and mechanical ventilation, developed and laboratory tests showed elevated serum anti-AChR Ab(130 nmol/l), antinuclear antibody( ×640 serum dilution, speckled pattern) and anti-RNP Ab(129...
September 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/27567293/pathways-linked-to-internuclear-ophthalmoplegia-on-diffusion-tensor-imaging-in-a-case-with-midbrain-infarction
#17
Haruka Takeshige, Yuji Ueno, Koji Kamagata, Fuyuko Sasaki, Kazuo Yamashiro, Ryota Tanaka, Shigeki Aoki, Nobutaka Hattori
BACKGROUND: Midbrain infarction shows diverse patterns of ophthalmoplegia; however, the association of ophthalmoplegia with a precise microanatomy has not been fully studied. Here, we report a patient with characteristic ophthalmoplegia and explore the associated pathologic fiber tracts using diffusion-tensor imaging (DTI). METHODS: A 21-year-old woman with an 11-year history of mixed connective tissue disease (MCTD) abruptly developed bilateral internuclear ophthalmoplegia (INO) with upward gaze and convergence palsies...
August 24, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27463267/ortner-s-syndrome-caused-by-pulmonary-arterial-hypertension-associated-with-mixed-connective-tissue-disease
#18
Mariko Ogawa-Momohara, Yoshinao Muro, Akihiro Hirashiki, Yasushi Fujimoto, Takahisa Kondo, Masashi Akiyama
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July 26, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27456208/autologous-platelet-rich-plasma-in-the-management-of-non-healing-vasculitic-ulcers
#19
Sankaran Sriram, Rajeswari Sankaralingam, Madeshwaran Mani, Tiruchengode Natesan Tamilselvam
AIM: To determine the role and efficacy of platelet rich plasma (PRP) in the healing of recalcitrant vasculitic ulcers and to study the rapidity of ulcer healing with respect to platelet concentration in the prepared PRP. METHODS: This is a pilot study which included 20 patients with biopsy-proven vasculitic ulcers after excluding human immunodeficiency virus, uncontrolled diabetes mellitus, hypertension, obesity, active smoking and platelet abnormalities in peripheral smear...
July 26, 2016: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/27453743/esophageal-disorders-in-mixed-connective-tissue-diseases
#20
A E Nica, L M Alexa, A O Ionescu, O Andronic, D N Păduraru
Extra Musculoskeletal manifestations are a distinct clinical entity that refers to a combination of clinical features, which are found in multiple rheumatic diseases. Besides the standard manifestations, other organs can be damaged such as the vascular system, skin, gastrointestinal tract, musculoskeletal system, cardiopulmonary system, hematologic system, kidneys, and the central nervous system. Among the gastrointestinal MCTD symptoms, the most frequent are the esophageal ones. Treatment of patients with MCTD must be performed by both medical and surgical multidisciplinary teams in order to provide a management suitable for the patients' needs...
April 2016: Journal of Medicine and Life
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