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Cell free dna gynecology

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https://www.readbyqxmd.com/read/27813114/the-value-of-the-first-trimester-ultrasound-in-the-era-of-cell-free-dna-screening
#1
Rashmi R Rao, Stephanie G Valderramos, Neil S Silverman, Christina S Han, Lawrence D Platt
OBJECTIVE: To describe the clinically relevant findings detected by the first trimester ultrasound (FTU) and to determine the additional value of the FTU compared to cell free DNA (cfDNA) alone. METHOD: Retrospective cohort study of patients undergoing a FTU at a maternal-fetal medicine referral practice. Fetal, gynecologic, and placental findings detected by ultrasound were analyzed with available cfDNA and diagnostic testing results. A subgroup analysis of positive ultrasound findings and cfDNA results was performed to assess the additional benefit of ultrasound evaluation in FT prenatal screening...
November 3, 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27357817/an-update-on-current-and-emerging-therapies-for-epithelial-ovarian-cancer-focus-on-poly-adenosine-diphosphate-ribose-polymerase-inhibition-and-antiangiogenesis
#2
Clement Chung, Rosetta Lee
Epithelial ovarian cancer is the leading cause of death from gynecologic tumors in western countries. Newly diagnosed epithelial ovarian cancer patients usually have good initial response to combination of platinum-based and taxane-based chemotherapy. However, most patients eventually experience relapses, and responses to subsequent therapies are generally short-lived. Intraperitoneal chemotherapy has been shown to improve survival outcomes, but toxicities and logistics limit its acceptance. Dose-dense schedule of paclitaxel combined with carboplatin remains controversial, and more studies are needed to validate this approach...
June 29, 2016: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/26830315/studying-platinum-sensitivity-and-resistance-in-high-grade-serous-ovarian-cancer-different-models-for-different-questions
#3
REVIEW
Nicolette G Alkema, G Bea A Wisman, Ate G J van der Zee, Marcel A T M van Vugt, Steven de Jong
High-grade serous ovarian cancer (HGSOC) has the highest mortality rate among all gynecological cancers. Patients are generally diagnosed in an advanced stage with the majority of cases displaying platinum resistant relapses. Recent genomic interrogation of large numbers of HGSOC patient samples indicated high complexity in terms of genetic aberrations, intra- and intertumor heterogeneity and underscored their lack of targetable oncogenic mutations. Sub-classifications of HGSOC based on expression profiles, termed 'differentiated', 'immunoreactive', 'mesenchymal' and 'proliferative', were shown to have prognostic value...
January 2016: Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
https://www.readbyqxmd.com/read/26785283/ovarian-cancer-treatment-in-mutation-carriers-brcaness
#4
Domenica Lorusso, Stefania Perotto
Epithelial ovarian cancer remains the most lethal gynecologic malignancy. During the last 15 years, there has been only marginal improvement in 5-year overall survival. These daunting statistics are compounded by the fact that despite all subtypes exhibiting striking heterogeneity, their systemic management remains identical. Retrospective studies have shown an improved prognosis, higher response rates to platinum-containing regimens, and longer treatment-free intervals between relapses in patients with BRCA 1 and BRCA 2 (BRCA1/2)-mutated ovarian cancer (BMOC) compared with patients who are not carriers of this mutation...
October 2016: Minerva Ginecologica
https://www.readbyqxmd.com/read/8333474/analysis-of-prognostic-factors-in-stage-i-epithelial-ovarian-carcinoma-importance-of-degree-of-differentiation-and-deoxyribonucleic-acid-ploidy-in-predicting-relapse
#5
I B Vergote, J Kaern, V M Abeler, E O Pettersen, L N De Vos, C G Tropé
OBJECTIVES: Our purpose was to identify prognostic factors in stage I epithelial invasive ovarian carcinoma. STUDY DESIGN: The traditional clinical and pathologic prognostic variables and deoxyribonucleic acid ploidy were analyzed in a group of 290 patients. RESULTS: A multivariate analysis identified degree of differentiation as the most powerful prognostic indicator of disease-free survival, followed by deoxyribonucleic acid ploidy and, finally, International Federation of Gynecology and Obstetrics (1986) stage...
July 1993: American Journal of Obstetrics and Gynecology
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