keyword
MENU ▼
Read by QxMD icon Read
search

gupta

keyword
https://www.readbyqxmd.com/read/28318958/the-association-between-carotid-artery-atherosclerosis-and-silent-brain-infarction-a-systematic-review-and-meta-analysis
#1
Caitlin Finn, Ashley E Giambrone, Gino Gialdini, Diana Delgado, Hediyeh Baradaran, Hooman Kamel, Ajay Gupta
BACKGROUND: Carotid atherosclerosis is responsible for ~20% of ischemic strokes, but it is unclear whether carotid disease is associated with the presence of downstream silent brain infarction (SBI). We performed a systematic review and meta-analysis to study the relationship between SBI and 2 separate manifestations of carotid atherosclerosis, carotid intima-media thickening (IMT) and luminal stenosis. METHODS: Ovid MEDLINE, Ovid Embase, and the Cochrane Library Database were searched with an additional search of references and citing articles of target studies...
March 15, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28318645/comparison-of-survivability-of-staphylococcus-aureus-and-spores-of-aspergillus-niger-on-commonly-used-floor-materials
#2
Mridula Gupta, Michael Bisesi, Jiyoung Lee
BACKGROUND: The survivability of Staphylococcus aureus and spores of Aspergillus niger was compared on 5 common floor materials. METHODS: Floor materials were inoculated with a known concentration of S aureus and spores of A niger on day 0. Their survivability was measured on days, 2, 7, 14, and 28 by bulk rinsate method and enumerated using culture-based method. RESULTS: The difference in change of S aureus levels was statistically significant for all tested days (P < ...
March 16, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28318625/mycophenolate-mofetil-is-inferior-to-tacrolimus-in-sustaining-remission-in-children-with-idiopathic-steroid-resistant-nephrotic-syndrome
#3
Aditi Sinha, Aarti Gupta, Mani Kalaivani, Pankaj Hari, Amit K Dinda, Arvind Bagga
Studies of nephrotic syndrome show that substitution of calcineurin inhibitors by mycophenolate mofetil (MMF) enables sustained remission and corticosteroid sparing and avoids therapy associated adverse effects. However, controlled studies in patients with steroid resistance are lacking. Here we examined the effect of switching from therapy with tacrolimus to MMF on disease course in an open-label, one-to-one randomized, controlled trial on children (one to 18 years old), recently diagnosed with steroid-resistant nephrotic syndrome, at a referral center in India...
March 15, 2017: Kidney International
https://www.readbyqxmd.com/read/28318350/clinical-course-and-outcomes-of-pediatric-tubercular-uveitis-in-north-india
#4
Savleen Kaur, Kanika Aggarwal, Aniruddha Agarwal, Deepti Suri, Anju Gupta, Ramandeep Singh, Reema Bansal, Surjit Singh, Nirbhai Singh, Amod Gupta, Vishali Gupta
PURPOSE: To analyze the clinical features, course, management, and outcomes of tubercular (TB) uveitis in the pediatric population and assess the response to anti-tubercular therapy (ATT). METHODS: Hospital records of children (≤16 years) from a large tertiary-care institute between January 2001 and December 2015 were reviewed. RESULTS: A total of 32 children (mean age: 10.7 ± 4.27 years; range 2-16) were diagnosed with TB-associated uveitis...
March 20, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28318349/visual-morbidity-and-ocular-complications-in-presumed-intraocular-tuberculosis-an-analysis-of-354-cases-from-a-non-endemic-population
#5
Dinesh Visva Gunasekeran, Bhaskar Gupta, Joao Cardoso, Carlos E Pavesio, Rupesh Agrawal
PURPOSE: To describe the visual morbidity associated with intraocular tuberculosis (TB) and to report ocular complications of intraocular TB. METHODS: Retrospective cohort study of patients diagnosed with intraocular TB at a tertiary referral eye care hospital in central London. Data on baseline and final best-corrected visual acuity (BCVA) along with ocular complications were collected and analyzed. RESULTS: In total, 354 patients with intraocular TB were included in this study...
March 20, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28318013/ethnic-identity-development-and-acculturation-preferences-among-minority-and-majority-youth-norms-and-contact
#6
Roberto González, Brian Lickel, Manisha Gupta, Linda R Tropp, Bernadette P Luengo Kanacri, Eduardo Mora, Pablo De Tezanos-Pinto, Christian Berger, Daniel Valdenegro, Oscar Cayul, Daniel Miranda, Patricio Saavedra, Michelle Bernardino
This article tests a longitudinal model of the antecedents and consequences of changes in identification with indigenous (Mapuche) among indigenous and nonindigenous youth in Chilean school contexts over a 6-month period (633 nonindigenous and 270 Mapuche students, Mages  = 12.47 and 12.80 years, respectively). Results revealed that in-group norms supporting contact and quality of intergroup contact at Time 1 predicted student's changes in Mapuche identification at Time 2, which in turn predicted changes in support for adoption of Chilean culture and maintenance of Mapuche culture at Time 2; some of the relationships between these variables were found to be moderated by age and ethnicity...
March 20, 2017: Child Development
https://www.readbyqxmd.com/read/28317328/evaluating-dosage-optimality-for-tofacitinib-an-oral-janus-kinase-inhibitor-in-plaque-psoriasis-and-the-influence-of-body-weight
#7
M M Hutmacher, K Papp, S Krishnaswami, K Ito, H Tan, R Wolk, H Valdez, C Mebus, S T Rottinghaus, P Gupta
Tofacitinib is an oral Janus kinase inhibitor. An integrated analysis was conducted to evaluate dosage optimality for tofacitinib in patients with moderate-to-severe plaque psoriasis and the impact of body weight on optimality in this patient population. Data were pooled from one phase IIb trial (2, 5, and 15 mg twice daily (b.i.d.)) and four phase III trials (5 and 10 mg b.i.d.). A longitudinal exposure-response model for Psoriasis Area and Severity Index (PASI) improvement (percent change from baseline) was established...
March 20, 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/28316927/probiotic-an-emerging-therapy-in-recolonizing-periodontal-pocket
#8
N D Gupta, Shweta Sharma, Vivek Kumar Sharma
One of the etiological factors in the pathogenesis of periodontitis is reduction or the absence of the so-called "beneficial bacteria". Most of the globally applied treatment approach is based on subgingival bacterial elimination but recolonization with less pathogenic bacteria is seen within weeks. Therefore, researchers have started focusing on shifting the current treatment approach from specific bacterial elimination to restoring periodontal pocket with beneficial bacteria. This alteration in the ecology of niches from the one with the pathological plaque to the one with the biofilm of commensals can be achieved via subgingival application of probiotics...
January 2017: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/28316386/successful-therapeutic-management-of-canine-isosporosis-in-puppies
#9
Nishiswapna Garanayak, A R Gupta, R C Patra
Four labrador male puppies were confirmed for the Isospora spp infection by direct smear and flotation method following complains of anorexia, haematemesis and haematochezia. The puppies were treated with trimethoprime and sulphamethoxazole @ 40 mg/kg body weight in combination with metronidazole @ 10 mg/kg body weight twice daily for 5 days which was supported with fluid therapy, aniemetics and plasma expanders. All the animals showed completed clinical recovery along with clearing of faecal oocyst.
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28316384/taxonomic-tools-for-the-identification-of-allogenarchopsisbareilliensis-n-sp-digenea-hemiuroidea-derogenidae-from-channastriata-of-rohilkhand-india-based-on-light-and-scanning-electron-microscopic-studies
#10
Neelima Gupta, Dileep K Gupta, Misako Urabe
The stomach of the freshwater snakehead murrel, Channastriata (n = 250) collected from fresh water habitats of Bareilly, Uttar Pradesh, India revealed Allogenarchopsis, a trematode parasite (Plagiorchiida: Derogenidae). An illustrated account of light (Olympus BX-53 with Cellsens software imaging system) and scanning electron microscopy (SEM) (Neo JCM-6000) of Allogenarchopsisbareilliensis n. sp. (prevalence 37 %, intensity 1-4 par/host) is provided. Light microscopy based studies warranting creation of a new species are the robust shape of the body with broad mid-body, blunt anterior and tapering posterior end, large ventral sucker, ratio of oral sucker: ventral sucker 1:3...
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28316383/condition-factor-and-organosomatic-indices-of-parasitized-rattus-rattus-as-indicators-of-host-health
#11
Neelima Gupta, D K Gupta, P K Sharma
This study describes the influence of parasitism (Trypanosoma lewisi and Cysticercus fasciolaris) on the condition factor, hepato and splenosomatic indices of the common house rat, Rattus rattus Linnaeus, 1758 from Rohilkhand, Uttar Pradesh, India. Examination of R. rattus (n = 389) revealed T. lewisi (prevalence 12.40 %; intensity14 parasites/1000 RBC) from the blood and C. fasciolaris (larval Taenia taeniaeformis) (prevalence 46.70 %; intensity 2-4 par/host) from the liver. Condition factor (K) and organosomatic indices [hepatosomatic index, spleenosomatic index (SSI)] were evaluated in two groups (Group I non pregnant, Group II pregnant) of female rats which were further subdivided into four subgroups each (a Uninfected, b T...
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28316063/endothelial-long-non-coding-rnas-regulated-by-oxidized-ldl
#12
Krishna K Singh, Pratiek N Matkar, Yi Pan, Adrian Quan, Vijay Gupta, Hwee Teoh, Mohammed Al-Omran, Subodh Verma
Oxidized low-density lipoprotein (oxLDL) plays a central role in the pathogenesis of atherosclerosis, in part via an effect to promote endothelial dysfunction. In the present study, we evaluated the expression profiles of long non-coding RNAs (lncRNAs) and protein-coding mRNAs in endothelial cells following oxLDL stimulation. LncRNAs and mRNAs from human umbilical vein endothelial cells (HUVECs) were profiled with the Arraystar Human lncRNA Expression Microarray V3.0 following 24 h of oxLDL treatment (100 µg/mL)...
March 18, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28315974/inherited-dna-repair-gene-mutations-detected-by-tumor-next-generation-sequencing-in-urinary-tract-cancers
#13
Sumati Gupta, Samantha Greenberg, Jade Grimmett, David Gaston, Neeraj Agarwal, William Lowrance, Joshua Schiffman, Wendy Kohlmann
Interpretation of next-generation sequencing (NGS) of tumor tissue in patients with advanced Urinary Tract Cancer (UTC) is performed to guide treatment selection but may reveal pathogenic variants with germline implications. We identified three patients with UTC with unexpected germline DNA repair gene mutations. Specific testing for these was prompted by the detection of these mutations by tumor NGS. All three patients were nonsmokers with a strong family history of cancer. Two patients had upper tract UTC with age at diagnosis in the 40 s...
March 18, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28315457/anticonvulsant-activity-and-acute-neurotoxic-profile-of-achyranthes-aspera-linn
#14
Dinesh Y Gawande, Dmitry Druzhilovsky, Raghbir Chand Gupta, Vladimir Poroikov, Rajesh Kumar Goel
ETHNOPHARMACOLOGICAL RELEVANCE: Root powder of Achyranthes aspera Linn. (A. aspera) belongs to family Amaranthaceae is used in Indian traditional medicine for the management of epilepsy and its efficacy is widely acclaimed among the different rural communities. AIM OF THE STUDY: The present study was aimed to establish the possible anticonvulsant effect of A. aspera methanolic root extract using acute anticonvulsant models and to evaluate the acute toxicity and neurotoxic potential A...
March 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28315437/homology-modeling-molecular-docking-and-molecular-dynamics-studies-of-the-catalytic-domain-of-chitin-deacetylase-from-cryptococcus-laurentii-strain-ry1
#15
Soumyadev Sarkar, Suchetana Gupta, Writachit Chakraborty, Sanjib Senapati, Ratan Gachhui
This study provides structural insights into chitin deacetylase, over-expressing under nitrogen limiting condition in Cryptococcus laurentii strain RY1. The enzyme converts chitin, the second most abundant natural biopolymer, to chitosan, which offers tremendous applications in diverse fields. To elucidate the structure-function relationship of this biologically and industrially important enzyme, a homology model of the catalytic domain was constructed. The stability of the structure was assessed by molecular dynamics simulation studies...
March 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28315424/diagnostic-criteria-for-oncocytic-renal-neoplasms-a-survey-of-urologic-pathologists
#16
Sean R Williamson, Ramya Gadde, Kiril Trpkov, Michelle S Hirsch, John R Srigley, Victor E Reuter, Liang Cheng, L Priya Kunju, Ravi Barod, Craig G Rogers, Brett Delahunt, Ondrej Hes, John N Eble, Ming Zhou, Jesse K McKenney, Guido Martignoni, Stewart Fleming, David J Grignon, Holger Moch, Nilesh S Gupta
Renal oncocytoma and chromophobe renal cell carcinoma (RCC) have been long recognized as distinct tumors; however, it remains unknown if uniform diagnostic criteria are used to distinguish these tumor types in practice. A survey was distributed to urologic pathologists regarding oncocytic tumors. Responses were received from 17/26 invitees. Histologically, >1 mitotic figure was regarded as most worrisome (n=10) or incompatible (n=6) with oncocytoma diagnosis. Interpretation of focal nuclear wrinkling, focal perinuclear clearing, and multinucleation depended on extent and did not necessarily exclude oncocytoma if minor...
March 14, 2017: Human Pathology
https://www.readbyqxmd.com/read/28315167/development-of-a-predictive-model-for-6-month-survival-in-patients-with-venous-thromboembolism-and-solid-malignancy-requiring-ivc-filter-placement
#17
Steven Y Huang, Bruno C Odisio, Sharjeel H Sabir, Joe E Ensor, Andrew S Niekamp, Tam T Huynh, Michael Kroll, Sanjay Gupta
PURPOSE: Our purpose was to develop a predictive model for short-term survival (i.e. <6 months) following inferior vena cava filter placement in patients with venous thromboembolism (VTE) and solid malignancy. METHODS: Clinical and laboratory parameters were retrospectively reviewed for patients with solid malignancy who received a filter between January 2009 and December 2011 at a tertiary care cancer center. Multivariate Cox proportional hazards modeling was used to assess variables associated with 6 month survival following filter placement in patients with VTE and solid malignancy...
March 17, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28314772/two-phylogenetically-and-compartmentally-distinct-cdp-diacylglycerol-synthases-cooperate-for-lipid-biogenesis-in-toxoplasma-gondii
#18
Pengfei Kong, Christoph-Martin Ufermann, Diana Lm Zimmermann, Qing Yin, Xun Suo, J Bernd Helms, Jos F Brouwers, Nishith Gupta
Toxoplasma gondii is among the most prevalent protozoan parasites, which infects a wide range of organisms including one-third of the human population. Its rapid intracellular replication within a vacuole requires efficient synthesis of glycerophospholipids. Cytidine diphosphate-diacylglycerol (CDP-DAG) serves as a major precursor for phospholipid synthesis. Given the peculiarities of lipid biogenesis, understanding the mechanism and physiological importance of CDP-DAG synthesis is particularly relevant in T...
March 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28314136/platelet-microparticle-inspired-clot-responsive-nanomedicine-for-targeted-fibrinolysis
#19
Christa L Pawlowski, Wei Li, Michael Sun, Kavya Ravichandran, DaShawn Hickman, Clarissa Kos, Gurbani Kaur, Anirban Sen Gupta
Intravascular administration of plasminogen activators is a clinically important thrombolytic strategy to treat occlusive vascular conditions. A major issue with this strategy is the systemic off-target drug action, which affects hemostatic capabilities and causes substantial hemorrhagic risks. This issue can be potentially resolved by designing technologies that allow thrombus-targeted delivery and site-specific action of thrombolytic drugs. To this end, leveraging a liposomal platform, we have developed platelet microparticle (PMP)-inspired nanovesicles (PMINs), that can protect encapsulated thrombolytic drugs in circulation to prevent off-target uptake and action, anchor actively onto thrombus via PMP-relevant molecular mechanisms and allow drug release via thrombus-relevant enzymatic trigger...
March 14, 2017: Biomaterials
https://www.readbyqxmd.com/read/28306735/effects-of-social-organization-trap-arrangement-and-density-sampling-scale-and-population-density-on-bias-in-population-size-estimation-using-some-common-mark-recapture-estimators
#20
Manan Gupta, Amitabh Joshi, T N C Vidya
Mark-recapture estimators are commonly used for population size estimation, and typically yield unbiased estimates for most solitary species with low to moderate home range sizes. However, these methods assume independence of captures among individuals, an assumption that is clearly violated in social species that show fission-fusion dynamics, such as the Asian elephant. In the specific case of Asian elephants, doubts have been raised about the accuracy of population size estimates. More importantly, the potential problem for the use of mark-recapture methods posed by social organization in general has not been systematically addressed...
2017: PloS One
keyword
keyword
83097
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"