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https://www.readbyqxmd.com/read/28186976/32-phosphorus-selectively-delivered-by-listeria-to-pancreatic-cancer-demonstrates-a-strong-therapeutic-effect
#1
Dinesh Chandra, Benson Chellakkan Selvanesan, Ziqiang Yuan, Steven K Libutti, Wade Koba, Amanda Beck, Kun Zhu, Arturo Casadevall, Ekaterina Dadachova, Claudia Gravekamp
Our laboratory has developed a novel delivery platform using an attenuated non-toxic and non-pathogenic bacterium Listeria monocytogenes that infects tumor cells and selectively survives and multiplies in metastases and primary tumors with help of myeloid-derived suppressor cells (MDSC) and immune suppression in the tumor microenvironment (TME). 32P was efficiently incorporated into the Listeria bacteria by starvation of the bacteria in saline, and then cultured in phosphorus-free medium complemented with 32P as a nutrient...
February 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28174305/the-mbio-american-academy-of-microbiology-submission-track-in-2017
#2
EDITORIAL
Arturo Casadevall, Thomas Shenk
No abstract text is available yet for this article.
February 7, 2017: MBio
https://www.readbyqxmd.com/read/28126951/reply-to-on-the-impact-factor-and-the-asm-editorial-policy
#3
Ferric C Fang, Arturo Casadevall
No abstract text is available yet for this article.
February 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28101535/the-case-for-adopting-the-species-complex-nomenclature-for-the-etiologic-agents-of-cryptococcosis
#4
Kyung J Kwon-Chung, John E Bennett, Brian L Wickes, Wieland Meyer, Christina A Cuomo, Kurt R Wollenburg, Tihana A Bicanic, Elizabeth Castañeda, Yun C Chang, Jianghan Chen, Massimo Cogliati, Françoise Dromer, David Ellis, Scott G Filler, Matthew C Fisher, Thomas S Harrison, Steven M Holland, Shigeru Kohno, James W Kronstad, Marcia Lazera, Stuart M Levitz, Michail S Lionakis, Robin C May, Popchai Ngamskulrongroj, Peter G Pappas, John R Perfect, Volker Rickerts, Tania C Sorrell, Thomas J Walsh, Peter R Williamson, Jianping Xu, Adrian M Zelazny, Arturo Casadevall
Cryptococcosis is a potentially lethal disease of humans/animals caused by Cryptococcus neoformans and Cryptococcus gattii. Distinction between the two species is based on phenotypic and genotypic characteristics. Recently, it was proposed that C. neoformans be divided into two species and C. gattii into five species based on a phylogenetic analysis of 115 isolates. While this proposal adds to the knowledge about the genetic diversity and population structure of cryptococcosis agents, the published genotypes of 2,606 strains have already revealed more genetic diversity than is encompassed by seven species...
January 2017: MSphere
https://www.readbyqxmd.com/read/28099836/antibodies-to-mycobacterium-tuberculosis
#5
Arturo Casadevall
No abstract text is available yet for this article.
19, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28066619/clinical-management-of-chronic-obstructive-pulmonary-disease-patients-with-muscle-dysfunction
#6
REVIEW
Joaquim Gea, Carme Casadevall, Sergi Pascual, Mauricio Orozco-Levi, Esther Barreiro
Muscle dysfunction is frequently observed in chronic obstructive pulmonary disease (COPD) patients, contributing to their exercise limitation and a worsening prognosis. The main factor leading to limb muscle dysfunction is deconditioning, whereas respiratory muscle dysfunction is mostly the result of pulmonary hyperinflation. However, both limb and respiratory muscles are also influenced by other negative factors, including smoking, systemic inflammation, nutritional abnormalities, exacerbations and some drugs...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28039306/acknowledgment-of-reviewers
#7
EDITORIAL
Arturo Casadevall
No abstract text is available yet for this article.
December 30, 2016: MBio
https://www.readbyqxmd.com/read/28031206/physiological-differences-in-c-neoformans-in-vitro-versus-in-vivo-and-their-effects-on-antifungal-susceptibility
#8
Nina T Grossman, Arturo Casadevall
Cryptococcus neoformans is an environmentally ubiquitous fungal pathogen that primarily causes disease in people with compromised immune systems, particularly those with advanced AIDS. There are estimated to be almost one million cases per year of cryptococcal meningitis in patients with human immunodeficiency virus, leading to over 600,000 annual deaths, with a particular burden in sub-Saharan Africa. Amphotericin B (AMB) and fluconazole (FLC) are key components of cryptococcal meningitis treatment: AMB is used for induction, FLC for consolidation, maintenance, and in occasional individuals, prophylaxis...
December 28, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28011050/could-the-addition-of-cetuximab-to-conventional-radiation-therapy-improve-organ-preservation-in-those-patients-with-locally-advanced-larynx-cancer-who-respond-to-induction-chemotherapy-an-organ-preservation-spanish-head-and-neck-cancer-cooperative-group-phase
#9
Ricard Mesía, Jose A Garcia-Saenz, Alicia Lozano, Miguel Pastor, Juan J Grau, Javier Martínez-Trufero, Julio Lambeaz, Joaquina Martínez-Galán, Jose R Mel, Belen González, Silvia Vázquez, Manel Mañós, Miren Taberna, Beatriz Cirauqui, Elvira Del Barco, Esther Casado, Jordi Rubió-Casadevall, Angles Rodríguez-Jaráiz, Juan J Cruz
PURPOSE: To evaluate the efficacy and safety of induction chemotherapy (IC) followed by bioradiotherapy (BRT) to achieve functional larynx preservation in the setting of locally advanced head and neck tumors. METHODS AND MATERIALS: This was a phase 2, open-label, multicenter study of patients with stage III and IVA laryngeal carcinoma who were candidates for total laryngectomy. The primary endpoint was the rate of survival with functional larynx (SFL) at 3 years, with a critical value to consider the study positive of SFL >59%...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27923983/sex-differences-in-function-and-structure-of-the-quadriceps-muscle-in-chronic-obstructive-pulmonary-disease-patients
#10
Pilar Ausín, Juana Martínez-Llorens, Marina Sabaté-Bresco, Carme Casadevall, Esther Barreiro, Joaquim Gea
Chronic obstructive pulmonary disease (COPD) is a complex disorder with extrapulmonary manifestations. Even though there is some knowledge regarding sex differences in the lung disease, little is known about extrapulmonary manifestations. Our aim was to analyze the specific profile of muscle dysfunction, structure, and biology in COPD women. Twenty-one women and 19 men with stable COPD as well as 15 controls were included. Nutritional status, physical activity, lung and muscle function, exercise capacity, and quality of life were assessed...
December 6, 2016: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/27872188/a-monoclonal-antibody-to-cryptococcus-neoformans-glucuronoxylomannan-manifests-hydrolytic-activity-for-both-peptides-and-polysaccharides
#11
Anthony Bowen, Maggie P Wear, Radames J B Cordero, Stefan Oscarson, Arturo Casadevall
Studies in the 1980s first showed that some natural antibodies were "catalytic" and able to hydrolyze peptide or phosphodiester bonds in antigens. Many naturally occurring catalytic antibodies have since been isolated from human sera and associated with positive and negative outcomes in autoimmune disease and infection. The function and prevalence of these antibodies, however, remain unclear. A previous study suggested that the 18B7 monoclonal antibody against glucuronoxylomannan (GXM), the major component of the Cryptococcus neoformans polysaccharide capsule, hydrolyzed a peptide antigen mimetic...
January 13, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27834205/rigorous-science-a-how-to-guide
#12
EDITORIAL
Arturo Casadevall, Ferric C Fang
Proposals to improve the reproducibility of biomedical research have emphasized scientific rigor. Although the word "rigor" is widely used, there has been little specific discussion as to what it means and how it can be achieved. We suggest that scientific rigor combines elements of mathematics, logic, philosophy, and ethics. We propose a framework for rigor that includes redundant experimental design, sound statistical analysis, recognition of error, avoidance of logical fallacies, and intellectual honesty...
November 8, 2016: MBio
https://www.readbyqxmd.com/read/27822548/asm-journals-eliminate-impact-factor-information-from-journal-websites
#13
EDITORIAL
Arturo Casadevall, Stefano Bertuzzi, Michael J Buchmeier, Roger J Davis, Harold Drake, Ferric C Fang, Jack Gilbert, Barbara M Goldman, Michael J Imperiale, Philip Matsumura, Alexander J McAdam, Marcela F Pasetti, Rozanne M Sandri-Goldin, Thomas Silhavy, Louis Rice, Jo-Anne H Young, Thomas Shenk
Many scientists attempt to publish their work in a journal with the highest possible journal impact factor (IF). Despite widespread condemnation of the use of journal IFs to assess the significance of published work, these numbers continue to be widely misused in publication, hiring, funding, and promotion decisions (1, 2).
July 2016: MSystems
https://www.readbyqxmd.com/read/27795401/reply-to-improving-microbiology-research-the-problems-are-less-statistical-and-more-biological
#14
Arturo Casadevall, Lee M Ellis, Erika W Davies, Margaret McFall-Ngai, Ferric C Fang
No abstract text is available yet for this article.
October 18, 2016: MBio
https://www.readbyqxmd.com/read/27775058/extracellular-vesicles-from-paracoccidioides-brasiliensis-induced-m1-polarization-in-vitro
#15
Thiago Aparecido da Silva, Maria Cristina Roque-Barreira, Arturo Casadevall, Fausto Almeida
Extracellular vesicles (EVs) released by eukaryotes, archaea, and bacteria contain proteins, lipids, polysaccharides, and other molecules. The cargo analysis of EVs shows that they contain virulence factors suggesting a role in the pathogenesis of infection. The proteome, lipidome, RNA content, and carbohydrate composition of EVs from Paracoccidioides brasiliensis and Paracoccidioides lutzii were characterized. However, the effects of P. brasiliensis EVs on the host immune system have not yet been investigated...
October 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27725930/combination-of-antiretroviral-drugs-and-radioimmunotherapy-specifically-kills-infected-cells-from-hiv-infected-individuals
#16
Dina Tsukrov, Alicia McFarren, Alfred Morgenstern, Frank Bruchertseifer, Eugene Dolce, Miroslaw K Gorny, Susan Zolla-Pazner, Joan W Berman, Ellie Schoenbaum, Barry S Zingman, Arturo Casadevall, Ekaterina Dadachova
Eliminating virally infected cells is an essential component of any HIV eradication strategy. Radioimmunotherapy (RIT), a clinically established method for killing cells using radiolabeled antibodies, was recently applied to target HIV-1 gp41 antigen expressed on the surface of infected cells. Since gp41 expression by infected cells is likely downregulated in patients on antiretroviral therapy (ART), we evaluated the ability of RIT to kill ART-treated infected cells using both in vitro models and lymphocytes isolated from HIV-infected subjects...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27716502/to-be-or-not-be-a-functional-antibody-against-tb
#17
COMMENT
Arturo Casadevall
In this issue of Cell, Lu et al. provide important insights on the efficacy of human antibodies to Mycobacterium tuberculosis and on how functional heterogeneity of the antibody response may explain a century of contradictory evidence for the role of humoral immunity in defense against tuberculosis.
October 6, 2016: Cell
https://www.readbyqxmd.com/read/27639628/revisiting-the-immunoglobulin-intramolecular-signaling-hypothesis
#18
Anthony Bowen, Arturo Casadevall
A generation ago, the immunoglobulin intramolecular signaling, or allosteric, hypothesis was abandoned in favor of the associative hypothesis, which posited that Fc receptor crosslinking produced the increased affinity of antigen-antibody complexes. This essay argues that there is sufficient evidence to resuscitate the allosteric hypothesis, at least for some antibodies.
November 2016: Trends in Immunology
https://www.readbyqxmd.com/read/27639035/trends-in-incidence-and-survival-analysis-in-non-melanoma-skin-cancer-from-1994-to-2012-in-girona-spain-a-population-based-study
#19
J Rubió-Casadevall, A M Hernandez-Pujol, M C Ferreira-Santos, G Morey-Esteve, L Vilardell, G Osca-Gelis, N Vilar-Coromina, R Marcos-Gragera
INTRODUCTION: We present an epidemiological study focused on Non-melanoma skin cancers (NMSC), including squamous cell carcinoma (SCC), basal cell carcinoma (BCC), Merkel cell carcinoma (MCC), dermatofibrosarcoma protuberans (DFS) and adnexal and skin appendages neoplasm (ASAN), a neoplasm understudied in cancer registries. MATERIAL AND METHODS: We analyze trends of incidence and survival of NMSC registered with the Cancer Registry of Girona, Spain. RESULTS: We found 14389 cases of NMSC, accounting 3,474 SCC, 10729 BCC, 33 MCC, 61 DFSP and 71 ASAN...
December 2016: Cancer Epidemiology
https://www.readbyqxmd.com/read/27583447/a-small-protein-associated-with-fungal-energy-metabolism-affects-the-virulence-of-cryptococcus-neoformans-in-mammals
#20
Erin E McClelland, Udupi A Ramagopal, Johanna Rivera, James Cox, Antonio Nakouzi, Moses M Prabu, Steven C Almo, Arturo Casadevall
The pathogenic yeast Cryptococcus neoformans causes cryptococcosis, a life-threatening fungal disease. C. neoformans has multiple virulence mechanisms that are non-host specific, induce damage and interfere with immune clearance. Microarray analysis of C. neoformans strains serially passaged in mice associated a small gene (CNAG_02591) with virulence. This gene, hereafter identified as HVA1 (hypervirulence-associated protein 1), encodes a protein that has homologs of unknown function in plant and animal fungi, consistent with a conserved mechanism...
September 2016: PLoS Pathogens
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