Rebecca Bromley, Naghme Adab, Matt Bluett-Duncan, Jill Clayton-Smith, Jakob Christensen, Katherine Edwards, Janette Greenhalgh, Ruaraidh A Hill, Cerian F Jackson, Sonia Khanom, Ronan N McGinty, Catrin Tudur Smith, Jennifer Pulman, Anthony G Marson
BACKGROUND: Prenatal exposure to certain anti-seizure medications (ASMs) is associated with an increased risk of major congenital malformations (MCM). The majority of women with epilepsy continue taking ASMs throughout pregnancy and, therefore, information on the potential risks associated with ASM treatment is required. OBJECTIVES: To assess the effects of prenatal exposure to ASMs on the prevalence of MCM in the child. SEARCH METHODS: For the latest update of this review, we searched the following databases on 17 February 2022: Cochrane Register of Studies (CRS Web), MEDLINE (Ovid, 1946 to February 16, 2022), SCOPUS (1823 onwards), and ClinicalTrials...
August 29, 2023: Cochrane Database of Systematic Reviews