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https://www.readbyqxmd.com/read/29776874/examining-risk-for-persistent-pain-among-adults-with-overweight-status
#1
REVIEW
Teresa Bigand, Marian Wilson, Ruth Bindler, Kenn Daratha
Obesity and persistent pain are public health concerns with associated high costs. Evidence supports an increased risk for reports of persistent pain among adults who are above the recommended body mass index level. However, data have not been clearly synthesized to report the risk for the two co-occurring conditions. Even less is known about how overweight status that does not reach the level of obesity is related to pain. Thus, the aim driving this review was to calculate the risk and odds ratios of chronic pain among adults with an overweight body mass index...
May 15, 2018: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/29774553/alkyl-glucosides-newly-identified-allergens-in-foam-wound-dressings
#2
Stefan Kerre, Tine Strobbe, Tania Naessens, Mart Theunis, Kenn Foubert, Olivier Aerts
No abstract text is available yet for this article.
May 17, 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29763881/orally-administered-brown-seaweed-derived-%C3%AE-glucan-effectively-restrained-development-of-gastric-dysplasia-in-a4gnt-ko-mice-that-spontaneously-develop-gastric-adenocarcinoma
#3
Mark Joseph Desamero, Shigeru Kakuta, James Kenn Chambers, Kazuyuki Uchida, Satoshi Hachimura, Masaya Takamoto, Jun Nakayama, Hiroyuki Nakayama, Shigeru Kyuwa
β-Glucan refers to a heterogeneous group of chemically defined storage polysaccharides containing β-(1,3)-d-linked glucose polymers with branches connected by either β-(1,4) or β-(1,6) glycosidic linkage. To date, an extensive amount of scientific evidence supports their multifunctional biological activities, but their potential involvement in the progression of premalignant lesions remains to be clarified. A4gnt KO mice that lack α1,4-N-acetylglucosamine-capped O-glycans in gastric gland mucin are a unique animal model for gastric cancer because the mutant mice spontaneously develop gastric cancer through hyperplasia-dysplasia-adenocarcinoma sequence...
May 12, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29729396/cerebral-oxygen-availability-during-exercise-in-copd-patients-with-cognitive-impairment
#4
Vasileios Andrianopoulos, Ioannis Vogiatzis, Rainer Gloeckl, Robert Bals, Rembert A Koczulla, Klaus Kenn
Insufficient cerebral blood flow regulation to meet increasing metabolic demand during physical exertion could be associated with cognitive impairment. We compared cerebral oxygen availability during exercise in cognitively impaired (CI) to cognitively normal (CN) COPD patients. Fifty-two patients (FEV1 : 51 ± 16%) were classified as CN or CI according to the Montreal Cognitive Assessment. Patients performed cycle-ergometry at 75% peak capacity with continuous measurement of Near-Infrared Spectroscopy frontal-cortex Tissue oxygen Saturation Index (TSI), cerebral haemoglobin indices (oxy/deoxy/total- Hb), transcutaneous carbon-dioxide partial pressure (TcPCO2 ), and arterial oxygen saturation (SpO2 )...
May 2, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29695680/proliferative-changes-in-the-adrenal-medulla-of-aged-chinese-native-pigs
#5
Koji Uetsuka, Takayuki Suzuki, James Kenn Chambers, Kazuyuki Uchida, Hiroyuki Nakayama, Kunio Doi, Tetsuo Nunoya
Four aged retired Chinese native pigs, three females and one male, estimated as over 10-year-old, were subjected to autopsy because of infertility due to aging. Grossly, nodular lesions were found bilaterally in the adrenal medulla of all four pigs. Based on the gross and the histopathological findings, they were diagnosed as either medullary nodular hyperplasia or pheochromocytoma. Immunohistochemically, proliferating cells of all these lesions were immuno-positive for chromogranin-A, indicating adrenal medulla-derived...
April 25, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29694066/floquet-engineering-in-quantum-chains
#6
D M Kennes, A de la Torre, A Ron, D Hsieh, A J Millis
We consider a one-dimensional interacting spinless fermion model, which displays the well-known Luttinger liquid (LL) to charge density wave (CDW) transition as a function of the ratio between the strength of the interaction U and the hopping J. We subject this system to a spatially uniform drive which is ramped up over a finite time interval and becomes time periodic in the long-time limit. We show that by using a density matrix renormalization group approach formulated for infinite system sizes, we can access the large-time limit even when the drive induces finite heating...
March 23, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29688905/impact-of-adoption-of-a-comprehensive-electronic-health-record-on-nursing-work-and-caring-efficacy
#7
Elizabeth Schenk, Ruth Schleyer, Cami R Jones, Sarah Fincham, Kenn B Daratha, Karen A Monsen
Nurses in acute care settings are affected by the technologies they use, including electronic health records. This study investigated the impacts of adoption of a comprehensive electronic health record by measuring nursing locations and interventions in three units before and 12 months after adoption. Time-motion methodology with a handheld recording platform based on Omaha System standardized terminology was used to collect location and intervention data. In addition, investigators administered the Caring Efficacy Scale to better understand the effects of the electronic health record on nursing care efficacy...
April 23, 2018: Computers, Informatics, Nursing: CIN
https://www.readbyqxmd.com/read/29677221/a-2015-outbreak-of-flea-borne-rickettsiosis-in-san-gabriel-valley-los-angeles-county-california
#8
Kimberly Nelson, Alice N Maina, Angela Brisco, Chelsea Foo, Curtis Croker, Van Ngo, Rachel Civen, Allen L Richards, Kenn Fujioka, J Wakoli Wekesa
Although flea-borne rickettsiosis is endemic in Los Angeles County, outbreaks are rare. In the spring of 2015 three human cases of flea-borne rickettsiosis among residents of a mobile home community (MHC) prompted an investigation. Fleas were ubiquitous in common areas due to presence of flea-infested opossums and overabundant outdoor cats and dogs. The MHC was summarily abated in June 2015, and within five months, flea control and removal of animals significantly reduced the flea population. Two additional epidemiologically-linked human cases of flea-borne rickettsiosis detected at the MHC were suspected to have occurred before control efforts began...
April 20, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29625042/activation-of-the-stringent-response-by-loading-of-rela-trna-complexes-at-the-ribosomal-a-site
#9
Kristoffer Skovbo Winther, Mohammad Roghanian, Kenn Gerdes
RelA/SpoT homologs (RSHs) are ubiquitous bacterial enzymes that synthesize and hydrolyze (p)ppGpp in response to environmental challenges. Bacteria cannot survive in hosts and produce infection without activating the (p)ppGpp-mediated stringent response, but it is not yet understood how the enzymatic activities of RSHs are controlled. Using UV crosslinking and deep sequencing, we show that Escherichia coli RelA ((p)ppGpp synthetase I) interacts with uncharged tRNA without being activated. Amino acid starvation leads to loading of cognate tRNA⋅RelA complexes at vacant ribosomal A-sites...
April 5, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29610676/pregnant-or-recently-pregnant-opioid-users-contraception-decisions-perceptions-and-preferences
#10
Rebecca L Fischbein, Bethany G Lanese, Lynn Falletta, Kelsey Hamilton, Jennifer A King, Deric R Kenne
Background: Multiple factors are linked to extremely high unintended pregnancy rates among women who use opioids, including various barriers to contraception adherence. These include patient level barriers such as lack of knowledge and education about highly effective contraception, and potential provider barriers. Using a mixed-methods framework to examine the contraception-related perceptions and preferences of opioid using women is a necessary next step to understanding this phenomenon...
2018: Contraception and reproductive medicine
https://www.readbyqxmd.com/read/29567423/alzheimer-disease-associated-variants-in-sorl1-accelerate-dementia-development-in-parkinson-disease
#11
Jodi Maple-Grødem, Janete Chung, Kristin Aaser Lunde, Charalampos Tzoulis, Ole-Bjørn Tysnes, Kenn Freddy Pedersen, Guido Alves
OBJECTIVE: Dementia in Parkinson disease (PD) is a common occurrence, and shows a marked overlap at a clinical and pathological level with Alzheimer's disease (AD), suggesting they share underlying disease mechanisms. Genetic variants in SORL1 have been identified in patients with AD, but a possible role in other dementias is unknown. The aim of this study was to investigate whether common polymorphisms in SORL1 affect the risk of developing dementia in a population-based cohort of patients with incident PD...
March 19, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29558009/delirium-b%C3%A3-r-bed%C3%A3-mas-enhetligt-och-strukturerat-i-v%C3%A3-rden
#12
Yvonne A Johansson, Theofanis Tsevis, Nenad Bogdanovic, Elisabeth Kenne Sarenmalm
No abstract text is available yet for this article.
March 13, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29543836/beware-the-intruder-real-time-observation-of-infiltrated-neutrophils-and-neutrophil-microglia-interaction-during-stroke-in-vivo
#13
Jens Neumann, Sophie Henneberg, Susanne von Kenne, Niklas Nolte, Andreas J Müller, Burkhart Schraven, Michael W Görtler, Klaus G Reymann, Matthias Gunzer, Monika Riek-Burchardt
Inflammation plays an important role in the pathogenesis of ischemic stroke including an acute and prolonged inflammatory process. The role of neutrophil granulocytes as first driver of the immune reaction from the blood site is under debate due to controversial findings. In bone marrow chimeric mice we were able to study the dynamics of tdTomato-expressing neutrophils and GFP-expressing microglia after photothrombosis using intravital two-photon microscopy. We demonstrate the infiltration of neutrophils into the brain parenchyma and confirm a long-lasting contact between neutrophils and microglia as well as an uptake of neutrophils by microglia clearing the brain from peripheral immune cells...
2018: PloS One
https://www.readbyqxmd.com/read/29541058/dopaminergic-and-opioid-pathways-associated-with-impulse-control-disorders-in-parkinson-s-disease
#14
Aleksander H Erga, Ingvild Dalen, Anastasia Ushakova, Janete Chung, Charalampos Tzoulis, Ole Bjørn Tysnes, Guido Alves, Kenn Freddy Pedersen, Jodi Maple-Grødem
Introduction: Impulse control disorders (ICDs) are frequent non-motor symptoms in Parkinson's disease (PD), with potential negative effects on the quality of life and social functioning. ICDs are closely associated with dopaminergic therapy, and genetic polymorphisms in several neurotransmitter pathways may increase the risk of addictive behaviors in PD. However, clinical differentiation between patients at risk and patients without risk of ICDs is still troublesome. The aim of this study was to investigate if genetic polymorphisms across several neurotransmitter pathways were associated with ICD status in patients with PD...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29539647/mood-components-in-cocoa-and-chocolate-the-mood-pyramid
#15
Emmy Tuenter, Kenn Foubert, Luc Pieters
Cocoa and chocolate, prepared from cocoa beans that originate from the fruits of the cocoa tree Theobroma cacao , have a long-standing reputation as healthy food, including mood-enhancing effects. In spite of many clinical trials with chocolate, cocoa, or its constituents, the mechanisms of action on mood and cognition remain unclear. More in particular, it is still controversial which constituents may contribute to the psychopharmacological activities, ranging from the major cacao flavanols and methylxanthines to the minor amines, amides, and alkaloids...
March 14, 2018: Planta Medica
https://www.readbyqxmd.com/read/29523426/in-hospital-sepsis-mortality-rates-comparing-tertiary-and-non-tertiary-hospitals-in-washington-state
#16
Gail G Salvatierra, Bernice G Gulek, Baran Erdik, Deborah Bennett, Kenn B Daratha
BACKGROUND: More than a million people a year in the United States experience sepsis or sepsis-related complications, and sepsis remains the leading cause of in-hospital deaths. Unlike many other leading causes of in-hospital mortality, sepsis detection and treatment are not dependent on the presence of any technology or services that differ between tertiary and non-tertiary hospitals. OBJECTIVE: To compare sepsis mortality rates between tertiary and non-tertiary hospitals in Washington State...
March 6, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29523017/-guideline-for-the-diagnosis-and-treatment-of-copd-patients-issued-by-the-german-respiratory-society-and-the-german-atemwegsliga-in-cooperation-with-the-austrian-society-of-pneumology
#17
C Vogelmeier, R Buhl, O Burghuber, C-P Criée, S Ewig, J Godnic-Cvar, S Hartl, F Herth, P Kardos, K Kenn, D Nowak, K F Rabe, M Studnicka, H Watz, T Welte, W Windisch, H Worth
This document is a revision of the guideline for diagnosis and treatment of COPD that replaces the version from 2007. A multitude of recent reports regarding risk factors, diagnosis, assessment, prevention and pharmacological as well as non-pharmacological treatment options made a major revision mandatory. The new guideline is based on the GOLD document taking into account specifics in Germany and Austria.
April 2018: Pneumologie
https://www.readbyqxmd.com/read/29514352/the-reliability-of-electronic-health-record-data-used-for-obstetrical-research
#18
Molly R Altman, Karen Colorafi, Kenn B Daratha
BACKGROUND: Hospital electronic health record (EHR) data are increasingly being called upon for research purposes, yet only recently has it been tested to examine its reliability. Studies that have examined reliability of EHR data for research purposes have varied widely in methods used and field of inquiry, with little reporting of the reliability of perinatal and obstetric variables in the current literature. OBJECTIVE: To assess the reliability of data extracted from a commercially available inpatient EHR as compared with manually abstracted data for common attributes used in obstetrical research...
January 2018: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29511080/novel-p-ppgpp-binding-and-metabolizing-proteins-of-escherichia-coli
#19
Yong Zhang, Eva Zborníková, Dominik Rejman, Kenn Gerdes
The alarmone (p)ppGpp plays pivotal roles in basic bacterial stress responses by increasing tolerance of various nutritional limitations and chemical insults, including antibiotics. Despite intensive studies since (p)ppGpp was discovered over 4 decades ago, (p)ppGpp binding proteins have not been systematically identified in Escherichia coli We applied DRaCALA (<u>d</u>ifferential <u>ra</u>dial <u>c</u>apillary <u>a</u>ction of <u>l</u>igand <u>a</u>ssay) to identify (p)ppGpp-protein interactions...
March 6, 2018: MBio
https://www.readbyqxmd.com/read/29503935/lacrimal-gland-enlargement-as-an-early-clinical-or-radiological-sign-in-thyroid-orbitopathy
#20
James Khu, Kenn A Freedman
Purpose: Characteristic ophthalmic signs of Thyroid Orbitopathy (TO) include exophthalmos, eyelid retraction, eyelid edema, restrictive extraocular myopathy, and optic neuropathy. In addition lacrimal gland (LG) enlargement can be observed in these patients. However TO has not usually been considered in the differential diagnosis of cases of isolated LG enlargement. Observations: A female patient at our institution (Texas Tech) was seen over a period from 2006 to 2012...
April 2017: American Journal of Ophthalmology Case Reports
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