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Jens Neumann, Sophie Henneberg, Susanne von Kenne, Niklas Nolte, Andreas J Müller, Burkhart Schraven, Michael W Görtler, Klaus G Reymann, Matthias Gunzer, Monika Riek-Burchardt
Inflammation plays an important role in the pathogenesis of ischemic stroke including an acute and prolonged inflammatory process. The role of neutrophil granulocytes as first driver of the immune reaction from the blood site is under debate due to controversial findings. In bone marrow chimeric mice we were able to study the dynamics of tdTomato-expressing neutrophils and GFP-expressing microglia after photothrombosis using intravital two-photon microscopy. We demonstrate the infiltration of neutrophils into the brain parenchyma and confirm a long-lasting contact between neutrophils and microglia as well as an uptake of neutrophils by microglia clearing the brain from peripheral immune cells...
2018: PloS One
Aleksander H Erga, Ingvild Dalen, Anastasia Ushakova, Janete Chung, Charalampos Tzoulis, Ole Bjørn Tysnes, Guido Alves, Kenn Freddy Pedersen, Jodi Maple-Grødem
Introduction: Impulse control disorders (ICDs) are frequent non-motor symptoms in Parkinson's disease (PD), with potential negative effects on the quality of life and social functioning. ICDs are closely associated with dopaminergic therapy, and genetic polymorphisms in several neurotransmitter pathways may increase the risk of addictive behaviors in PD. However, clinical differentiation between patients at risk and patients without risk of ICDs is still troublesome. The aim of this study was to investigate if genetic polymorphisms across several neurotransmitter pathways were associated with ICD status in patients with PD...
2018: Frontiers in Neurology
Emmy Tuenter, Kenn Foubert, Luc Pieters
Cocoa and chocolate, prepared from cocoa beans that originate from the fruits of the cocoa tree Theobroma cacao , have a long-standing reputation as healthy food, including mood-enhancing effects. In spite of many clinical trials with chocolate, cocoa, or its constituents, the mechanisms of action on mood and cognition remain unclear. More in particular, it is still controversial which constituents may contribute to the psychopharmacological activities, ranging from the major cacao flavanols and methylxanthines to the minor amines, amides, and alkaloids...
March 14, 2018: Planta Medica
Gail G Salvatierra, Bernice G Gulek, Baran Erdik, Deborah Bennett, Kenn B Daratha
BACKGROUND: More than a million people a year in the United States experience sepsis or sepsis-related complications, and sepsis remains the leading cause of in-hospital deaths. Unlike many other leading causes of in-hospital mortality, sepsis detection and treatment are not dependent on the presence of any technology or services that differ between tertiary and non-tertiary hospitals. OBJECTIVE: To compare sepsis mortality rates between tertiary and non-tertiary hospitals in Washington State...
March 6, 2018: Journal of Emergency Medicine
C Vogelmeier, R Buhl, O Burghuber, C-P Criée, S Ewig, J Godnic-Cvar, S Hartl, F Herth, P Kardos, K Kenn, D Nowak, K F Rabe, M Studnicka, H Watz, T Welte, W Windisch, H Worth
This document is a revision of the guideline for diagnosis and treatment of COPD that replaces the version from 2007. A multitude of recent reports regarding risk factors, diagnosis, assessment, prevention and pharmacological as well as non-pharmacological treatment options made a major revision mandatory. The new guideline is based on the GOLD document taking into account specifics in Germany and Austria.
March 9, 2018: Pneumologie
Molly R Altman, Karen Colorafi, Kenn B Daratha
BACKGROUND:  Hospital electronic health record (EHR) data are increasingly being called upon for research purposes, yet only recently has it been tested to examine its reliability. Studies that have examined reliability of EHR data for research purposes have varied widely in methods used and field of inquiry, with little reporting of the reliability of perinatal and obstetric variables in the current literature. OBJECTIVE:  To assess the reliability of data extracted from a commercially available inpatient EHR as compared with manually abstracted data for common attributes used in obstetrical research...
January 2018: Applied Clinical Informatics
Yong Zhang, Eva Zborníková, Dominik Rejman, Kenn Gerdes
The alarmone (p)ppGpp plays pivotal roles in basic bacterial stress responses by increasing tolerance of various nutritional limitations and chemical insults, including antibiotics. Despite intensive studies since (p)ppGpp was discovered over 4 decades ago, (p)ppGpp binding proteins have not been systematically identified in Escherichia coli We applied DRaCALA (<u>d</u>ifferential<u>ra</u>dial<u>c</u>apillary<u>a</u>ction of<u>l</u>igand<u>a</u>ssay) to identify (p)ppGpp-protein interactions...
March 6, 2018: MBio
James Khu, Kenn A Freedman
Purpose: Characteristic ophthalmic signs of Thyroid Orbitopathy (TO) include exophthalmos, eyelid retraction, eyelid edema, restrictive extraocular myopathy, and optic neuropathy. In addition lacrimal gland (LG) enlargement can be observed in these patients. However TO has not usually been considered in the differential diagnosis of cases of isolated LG enlargement. Observations: A female patient at our institution (Texas Tech) was seen over a period from 2006 to 2012...
April 2017: American Journal of Ophthalmology Case Reports
Stefan Kerre, Tania Naessens, Mart Theunis, Kenn Foubert, An Goossens, Olivier Aerts
No abstract text is available yet for this article.
February 26, 2018: Contact Dermatitis
Etienne Maisonneuve, Manuela Castro-Camargo, Kenn Gerdes
No abstract text is available yet for this article.
February 22, 2018: Cell
Miguel R Carro-Temboury Martin Kühnel, Mariam Ahmad, Frederik Andersen, Ári Brend Bech, H Krestian L Bendixen, Patrick R Nawrocki, Anders J Bloch, Ilkay Bora, Tahreem A Bukhari, Nicolai V Bærentsen, Jens Carstensen, Smeeah Chima, Helene Colberg, Rasmus T Dahm, Joshua A Daniels, Nermin Dinckan, Mohamed El Idrissi, Ricci Erlandsen, Marc Førster, Yasmin Ghauri, Mikkel Gold, Andreas Hansen, Kenn Hansen, Mathias Helmsøe-Zinck, Mathias Henriksen, Sophus V Hoffmann, Louise O H Hyllested, Casper Jensen, Amalie S Kallenbach, Kirandip Kaur, Suheb R Khan, Emil T S Kjær, Bjørn Kristiansen, Sylvester Langvad, Philip M Lund, Chastine F Munk, Theis Møller, Ola M Z Nehme, Mathilde Rove Nejrup, Louise Nexø, Simon Skødt Holm Nielsen, Nicolai Niemeier, Lasse V Nikolajsen, Peter C T Nøhr, Dominik B Orlowski, Marc Overgaard, Jacob Skaarup Ovesen, Lucas Paustian, Adam S Pedersen, Mathias K Petersen, Camilla M Poulsen, Louis Praeger-Jahnsen, L Sonia Qureshi, Nicolai Ree, Louise S Schiermacher, Martin B Simris, Gorm Smith, Heidi N Smith, Alexander K Sonne, Marko R Zenulovic, Alma Winther Sørensen, Karina Sørensen, Emil Vogt, Andreas Væring, Jonas Westermann, Sevin B Özcan, Thomas Just Sørensen
Three series of ionic self-assembled materials based on anionic azo-dyes and cationic benzalkonium surfactants were synthesized and thin films were prepared by spin-casting. These thin films appear isotropic when investigated with polarized optical microscopy, although they are highly anisotropic. Here, three series of homologous materials were studied to rationalize this observation. Investigating thin films of ordered molecular materials relies to a large extent on advanced experimental methods and large research infrastructure...
February 15, 2018: Nanomaterials
J W Harter, D M Kennes, H Chu, A de la Torre, Z Y Zhao, J-Q Yan, D G Mandrus, A J Millis, D Hsieh
We have used a combination of ultrafast coherent phonon spectroscopy, ultrafast thermometry, and time-dependent Landau theory to study the inversion symmetry breaking phase transition at T_{c}=200  K in the strongly spin-orbit coupled correlated metal Cd_{2}Re_{2}O_{7}. We establish that the structural distortion at T_{c} is a secondary effect through the absence of any softening of its associated phonon mode, which supports a purely electronically driven mechanism. However, the phonon lifetime exhibits an anomalously strong temperature dependence that decreases linearly to zero near T_{c}...
January 26, 2018: Physical Review Letters
Lynn Falletta, Kelsey Hamilton, Rebecca Fischbein, Julie Aultman, Beth Kinney, Deric Kenne
Pregnant, opioid-using women represent a challenge to healthcare providers attempting to engage them in prenatal and substance abuse services. Limited, primarily international research suggests that child welfare clients have mixed feelings about Child Protective Services (CPS) and that fear of CPS may present a barrier to care. Understanding how pregnant opioid-using women in substance abuse treatment perceive CPS may be useful in encouraging substance abuse treatment initiation. Participants were currently or recently (within past 12 months) pregnant women with current or recent (within past 12 months) abuse/dependence of pharmaceutical opioids at a drug treatment facility...
February 9, 2018: Child Abuse & Neglect
Marthe Gurine Førland, Annika Öhrfelt, Ingvild Dalen, Ole-Bjørn Tysnes, Kaj Blennow, Henrik Zetterberg, Kenn Freddy Pedersen, Guido Alves, Johannes Lange
INTRODUCTION: Cerebrospinal fluid (CSF) total α-synuclein is considered a potential biomarker for Parkinson's disease (PD), but little is known about the evolution of this marker during the course of the disease. Our objective was to investigate whether CSF total α-synuclein concentrations change over time and are associated with motor and cognitive function in PD. METHODS: CSF total α-synuclein concentrations were quantified in 56 longitudinally followed PD patients, 27 of whom provided CSF repeatedly 2 and/or 4 years later...
January 31, 2018: Parkinsonism & related Disorders
Yvonne A Johansson, Ingrid Bergh, Iréne Ericsson, Elisabeth Kenne Sarenmalm
BACKGROUND: Delirium is common in older hospitalized patients, and is associated with negative consequences for the patients, next of kin, healthcare professionals and healthcare costs. It is important to understand its clinical features, as almost 40% of all cases in hospitals may be preventable. Yet, delirium in hospitalized patients is often unrecognized and untreated. Few studies describe thoroughly how delirium manifests itself in older hospitalized patients and what actions healthcare professionals take in relation to these signs...
February 6, 2018: BMC Geriatrics
Jongsoo Choi, Xiyu Duan, Haijun Li, Thomas D Wang, Kenn R Oldham
Use of a thin-film piezoelectric microactuator for axial scanning during multi-photon vertical cross-sectional imaging is described. The actuator uses thin-film lead-zirconate-titanate (PZT) to generate upward displacement of a central mirror platform, micro-machined from a silicon-on-insulator (SOI) wafer to dimensions compatible with endoscopic imaging instruments. Device modeling in this paper focuses on existence of frequencies near device resonance producing vertical motion with minimal off-axis tilt even in the presence of multiple vibration modes and non-uniformity in fabrication outcomes...
October 2017: Journal of Microelectromechanical Systems
Alexander Harms, Ditlev Egeskov Brodersen, Namiko Mitarai, Kenn Gerdes
Bacterial toxin-antitoxin (TA) modules are abundant genetic elements that encode a toxin protein capable of inhibiting cell growth and an antitoxin that counteracts the toxin. The majority of toxins are enzymes that interfere with translation or DNA replication, but a wide variety of molecular activities and cellular targets have been described. Antitoxins are proteins or RNAs that often control their cognate toxins through direct interactions and, in conjunction with other signaling elements, through transcriptional and translational regulation of TA module expression...
January 21, 2018: Molecular Cell
Gabriel J Kenne, Phani M Gummadidala, Mayomi H Omebeyinje, Ananda M Mondal, Dominic K Bett, Sandra McFadden, Sydney Bromfield, Nora Banaszek, Michelle Velez-Martinez, Chandrani Mitra, Isabelle Mikell, Saurabh Chatterjee, Josephine Wee, Anindya Chanda
An aspect of mycotoxin biosynthesis that remains unclear is its relationship with the cellular management of reactive oxygen species (ROS). Here we conduct a comparative study of the total ROS production in the wild-type strain (SU-1) of the plant pathogen and aflatoxin producer, Aspergillus parasiticus, and its mutant strain, AFS10, in which the aflatoxin biosynthesis pathway is blocked by disruption of its pathway regulator, aflR. We show that SU-1 demonstrates a significantly faster decrease in total ROS than AFS10 between 24 h to 48 h, a time window within which aflatoxin synthesis is activated and reaches peak levels in SU-1...
January 29, 2018: Toxins
Haris Nalakath Abubackar, María C Veiga, Christian Kennes
A two-stage continuous system with two stirred tank reactors in series was utilized to perform syngas fermentation using Clostridium carboxidivorans. The first bioreactor (bioreactor 1) was maintained at pH 6 to promote acidogenesis and the second one (bioreactor 2) at pH 5 to stimulate solventogenesis. Both reactors were operated in continuous mode by feeding syngas (CO:CO2:H2:N2; 30:10:20:40; vol%) at a constant flow rate while supplying a nutrient medium at different flow rates of 8.1, 15, 22 and 30 ml/h...
January 6, 2018: Bioresource Technology
R Buhl, R Bals, X Baur, D Berdel, C-P Criée, M Gappa, A Gillissen, T Greulich, P Haidl, E Hamelmann, P Kardos, K Kenn, L Klimek, S Korn, M Lommatzsch, H Magnussen, T Nicolai, D Nowak, O Pfaar, K F Rabe, J Riedler, T Ritz, K Schultz, A Schuster, T Spindler, C Taube, K Taube, C Vogelmeier, A von Leupold, F Wantke, S Weise, J Wildhaber, H Worth, A Zacharasiewicz
No abstract text is available yet for this article.
December 2017: Pneumologie
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