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https://www.readbyqxmd.com/read/27911342/impulsive-and-compulsive-behaviors-in%C3%A2-parkinson-disease-the-norwegian-parkwest-study
#1
Aleksander H Erga, Guido Alves, Jan Petter Larsen, Ole Bj Rn Tysnes, Kenn Freddy Pedersen
BACKGROUND: Impulsive and compulsive behaviors (ICBs) are frequent in Parkinson's disease (PD), but data from population-based cohorts is lacking. OBJECTIVES: To determine the frequency and associated demographic, clinical, neuropsychiatric and cognitive features of ICBs in a population-based PD cohort. METHODS: This cross-sectional study included 125 patients with PD and 159 age- and gender-matched normal controls recruited from the Norwegian ParkWest study...
November 30, 2016: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/27890490/fragmentation-of-daily-rhythms-associates-with-obesity-and-cardiorespiratory-fitness-in-adolescents-the-helena-study
#2
Marta Garaulet, Antonio Martinez-Nicolas, Jonatan R Ruiz, Kenn Konstabel, Idoia Labayen, Marcela González-Gross, Ascensión Marcos, Dénes Molnar, Kurt Widhalm, Jose Antonio Casajús, Stefaan De Henauw, Anthony Kafatos, Christina Breidenassel, Michael Sjöström, Manuel J Castillo, Luis A Moreno, Juan A Madrid, Francisco B Ortega
BACKGROUND & AIMS: Chronobiology studies periodic changes in living organisms and it has been proposed as a promising approach to investigate obesity. We analyze the association of the characteristics of the rest-activity rhythms with obesity, cardiorespiratory fitness and metabolic risk in adolescents from nine European countries. METHODS: 1044 adolescents (12.5-17.5 y) were studied. Circadian health was evaluated by actigraphy with accelerometers (Actigraph GT1M)...
November 5, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27887620/anatomy-meets-dentistry-linking-anatomy-and-clinical-practice-in-the-preclinical-dental-curriculum
#3
Nicole Rafai, Martin Lemos, Lieven Nils Kennes, Ayichah Hawari, Susanne Gerhardt-Szép, Irmgard Classen-Linke
BACKGROUND: Establishing a strong link early on between preclinical coursework and the clinical context is necessary for students to be able to recognize the practical relevance of the curriculum during their preclinical anatomical courses and to transfer knowledge more easily. Our objective was to enhance the clinical relevance of a preclinical anatomy course for second-year medical students of dentistry by implementing an interdisciplinary skills training course on "Palpation of the Head and Neck Muscles" and to measure the learning outcomes...
November 25, 2016: BMC Medical Education
https://www.readbyqxmd.com/read/27884655/zika-virus-infection-in-dexamethasone-immunosuppressed-mice-demonstrating-disseminated-infection-with-multi-organ-involvement-including-orchitis-effectively-treated-by-recombinant-type-i-interferons
#4
Jasper Fuk-Woo Chan, Anna Jinxia Zhang, Chris Chung-Sing Chan, Cyril Chik-Yan Yip, Winger Wing-Nga Mak, Houshun Zhu, Vincent Kwok-Man Poon, Kah-Meng Tee, Zheng Zhu, Jian-Piao Cai, Jessica Oi-Ling Tsang, Kenn Ka-Heng Chik, Feifei Yin, Kwok-Hung Chan, Kin-Hang Kok, Dong-Yan Jin, Rex Kwok-Him Au-Yeung, Kwok-Yung Yuen
BACKGROUND: Disseminated or fatal Zika virus (ZIKV) infections were reported in immunosuppressed patients. Existing interferon-signaling/receptor-deficient mouse models may not be suitable for evaluating treatment effects of recombinant interferons. METHODS: We developed a novel mouse model for ZIKV infection by immunosuppressing BALB/c mice with dexamethasone. RESULTS: Dexamethasone-immunosuppressed male mice (6-8weeks) developed disseminated infection as evidenced by the detection of ZIKV-NS1 protein expression and high viral loads in multiple organs...
November 12, 2016: EBioMedicine
https://www.readbyqxmd.com/read/27874037/visualizing-epithelial-expression-of-egfr-in-vivo-with-distal-scanning-side-viewing-confocal-endomicroscope
#5
Xiyu Duan, Haijun Li, Juan Zhou, Quan Zhou, Kenn R Oldham, Thomas D Wang
Confocal endomicroscopy is an emerging imaging technology that has recently been introduced into the clinic to instantaneously collect "optical biopsies" in vivo with histology-like quality. Here, we demonstrate a fast scanner located in the distal end of a side-viewing instrument using a compact lens assembly with numerical aperture of 0.5 to achieve a working distance of 100 μm and field-of-view of 300 × 400 μm(2). The microelectromechanical systems (MEMS) mirror was designed based on the principle of parametric resonance and images at 5 frames per second...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27847349/assessing-the-viability-of-social-media-for-disseminating-evidence-based-nutrition-practice-guideline-through-content-analysis-of-twitter-messages-and-health-professional-interviews-an-observational-study
#6
Rosa K Hand, Deric Kenne, Taylor M Wolfram, Jenica K Abram, Michael Fleming
BACKGROUND: Given the high penetration of social media use, social media has been proposed as a method for the dissemination of information to health professionals and patients. This study explored the potential for social media dissemination of the Academy of Nutrition and Dietetics Evidence-Based Nutrition Practice Guideline (EBNPG) for Heart Failure (HF). OBJECTIVES: The objectives were to (1) describe the existing social media content on HF, including message content, source, and target audience, and (2) describe the attitude of physicians and registered dietitian nutritionists (RDNs) who care for outpatient HF patients toward the use of social media as a method to obtain information for themselves and to share this information with patients...
November 15, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27819004/comparison-of-perineal-sonographically-measured-and-functional-urodynamic-urethral-length-in-female-urinary-incontinence
#7
Laila Najjari, Nadine Janetzki, Lieven Kennes, Elmar Stickeler, Julia Serno, Julia Behrendt
Objectives. To detect the anatomical insufficiency of the urethra and to propose perineal ultrasound as a useful, noninvasive tool for the evaluation of incontinence, we compared the anatomical length of the urethra with the urodynamic functional urethral length. We also compared the urethral length between continent and incontinent females. Methods. 149 female patients were enrolled and divided into four groups (stress, urge, or mixed incontinence; control). Sonographically measured urethral length (SUL) and urodynamic functional urethral length (FUL) were analyzed statistically...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27776377/saponins-and-flavonoids-from-an-infusion-of-herniaria-hirsuta
#8
Ines van Dooren, Kenn Foubert, Sebastiaan Bijttebier, Mart Theunis, Stefaniya Velichkova, Magda Claeys, Luc Pieters, Vassiliki Exarchou, Sandra Apers
Stone diseases present a major health problem in the Western society, since both urinary and biliary stones occur with a relatively high prevalence of 10-12 % and 10-20 %, respectively, and demonstrate a high recurrence rate. At the moment treatment is mainly based on interventional procedures, or prophylactic and dissolution therapy. However, many of the current drugs cause severe side effects, and therefore, there is an increasing interest in natural medicines. At the moment no registered herbal medicinal products are available for treatment of gallstones...
October 24, 2016: Planta Medica
https://www.readbyqxmd.com/read/27765447/-epidemiological-and-clinical-aspects-of-tropical-endemic-limbo-conjunctivitis-in-students-in-yaound%C3%A3
#9
E Epée, G Koki, V A Dohvoma, C Kenne, N P Biangoup, O Tocke, C Mvilongo, A L Bella, C Ebana Mvogo
INTRODUCTION: TELC, tropical endemic limbo-conjunctivitis, is a keratoconjunctivitis seen more frequently in dry intertropical settings than humid ones. We aim to determine the epidemiologic and clinical profile of this condition in a city with a humid equatorial climate. PATIENTS AND METHODS: During first third of 2014, we conducted a cross-sectional descriptive study in schools. Included were children aged 3-15 years who received parental consent. The selection was conducted in two steps...
October 17, 2016: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/27737476/triterpenoid-saponins-from-maesa-argentea-leaves
#10
Kenn Foubert, Taposh Gorella, Ahmad Faizal, Paul Cos, Louis Maes, Sandra Apers, Danny Geelen, Luc Pieters
Within an ongoing research program on saponins with potential antileishmanial activity, four previously undescribed saponins were isolated from Maesa argentea leaves and identified by LC-MS/MS, GC-MS, and 1D and 2D NMR spectroscopy as 3β-O-{([β-D-glucopyranosyl-(1 → 2)-α-L-rhamnopyranosyl-(1 → 2)-β-D-galactopyranosyl-(1 → 3)]-[β-D-galactopyranosyl-(1 → 2)]-β-D-glucuronopyranosyl)}-21β-angeloyloxy-22α-butanoyloxy-13β,28-oxidoolean-16α,28α-diol (1), 3β-O-{([β-D-glucopyranosyl-(1 → 2)-α-L-rhamnopyranosyl-(1 → 2)-β-D-galactopyranosyl-(1 → 3)]-[β-D-galactopyranosyl-(1 → 2)]-β-D-glucuronopyranosyl)}-21β,22α-angeloyloxy-13β,28-oxidoolean-16α,28α-diol (2), 3β-O-{([β-D-glucopyranosyl-(1 → 2)-α-L-rhamnopyranosyl-(1 → 2)-β-D-galactopyranosyl-(1 → 3)]-[β-D-galactopyranosyl-(1 → 2)]-β-D-glucuronopyranosyl)}-21β-angeloyloxy-22α-(E)-cinnamoyloxy-13β,28-oxidoolean-16α,28α-diol (3), and 3β-O-{([α-L-rhamnopyranosyl-(1 → 2)-β-D-galactopyranosyl-(1 → 3)]-[β-D-galactopyranosyl-(1 → 2)]-β-D-glucuronopyranosyl)}-21β-angeloyloxy-22α-(E)-cinnamoyloxy-13β,28-oxidoolean-16α,28α-diol (4)...
October 13, 2016: Planta Medica
https://www.readbyqxmd.com/read/27725008/diet-misreporting-can-be-corrected-confirmation-of-the-association-between-energy-intake-and-fat-free-mass-in-adolescents
#11
Uku Vainik, Kenn Konstabel, Evelin Lätt, Jarek Mäestu, Priit Purge, Jaak Jürimäe
Subjective energy intake (sEI) is often misreported, providing unreliable estimates of energy consumed. Therefore, relating sEI data to health outcomes is difficult. Recently, Börnhorst et al. compared various methods to correct sEI-based energy intake estimates. They criticised approaches that categorise participants as under-reporters, plausible reporters and over-reporters based on the sEI:total energy expenditure (TEE) ratio, and thereafter use these categories as statistical covariates or exclusion criteria...
October 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27697232/the-development-and-use-of-a-new-methodology-to-reconstruct-courses-of-admission-and-ambulatory-care-based-on-the-danish-national-patient-registry
#12
Sophie Gubbels, Kenn Schultz Nielsen, Jakob Sandegaard, Kåre Mølbak, Jens Nielsen
INTRODUCTION: The Danish National Patient Registry (DNPR) contains clinical and administrative data on all patients treated in Danish hospitals. The data model used for reporting is based on standardized coding of contacts rather than courses of admissions and ambulatory care. METHODS: To reconstruct a coherent picture of courses of admission and ambulatory care, we designed an algorithm with 28 rules that manages transfers between departments, between hospitals and inconsistencies in the data, e...
November 2016: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27686000/different-training-induced-skeletal-muscle-adaptations-in-copd-patients-with-and-without-alpha-1-antitrypsin-deficiency
#13
Inga Jarosch, Sebastian Gehlert, Daniel Jacko, Rembert Andreas Koczulla, Marion Wencker, Tobias Welte, Wilhelm Bloch, Sabina Janciauskiene, Klaus Kenn
BACKGROUND: Pulmonary rehabilitation (PR) improves oxidative capacity of peripheral muscles in patients with chronic obstructive pulmonary disease (COPD). The exercise-induced oxidative skeletal muscle adaptation in COPD patients with inherited alpha-1 antitrypsin deficiency (A1ATD) has not been studied. OBJECTIVES: To compare PR effects on skeletal muscle adaptation in COPD patients with and without A1ATD. METHODS: Nine COPD patients with A1ATD (genotype PiZZ, 6 receiving A1AT augmentation therapy), and 10 'usual' COPD patients (genotype PiMM) performed an incremental cycling test and underwent musculus vastus lateralis biopsies before and after a 3-week PR program including exercise training...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27680195/perceptions-of-harm-and-reasons-for-misuse-of-prescription-opioid-drugs-and-reasons-for-not-seeking-treatment-for-physical-or-emotional-pain-among-a-sample-of-college-students
#14
Deric R Kenne, Kelsey Hamilton, Lauren Birmingham, Willie H Oglesby, Rebecca L Fischbein, Douglas L Delahanty
BACKGROUND: Since the early 1990s, the United States has seen a significant increase in the prevalence of prescription opioid misuse. Despite benefits prescription opioids provide, misuse can be fatal. OBJECTIVES: The current study was designed to investigate the prevalence of prescription opioid misuse, perceived harm of misuse, and reasons for misuse for physical or emotional pain instead of seeking professional medical or mental health treatment. METHODS: Survey data were collected in the fall of 2013 via an online survey to a random sample of 668 students from a public Midwestern university...
September 28, 2016: Substance Use & Misuse
https://www.readbyqxmd.com/read/27672159/hypothesis-type-i-toxin-antitoxin-genes-enter-the-persistence-field-a-feedback-mechanism-explaining-membrane-homoeostasis
#15
REVIEW
Kenn Gerdes
Bacteria form persisters, cells that are tolerant to multiple antibiotics and other types of environmental stress. Persister formation can be induced either stochastically in single cells of a growing bacterial ensemble, or by environmental stresses, such as nutrient starvation, in a subpopulation of cells. In many cases, the molecular mechanisms underlying persistence are still unknown. However, there is growing evidence that, in enterobacteria, both stochastically and environmentally induced persistence are controlled by the second messenger (p)ppGpp...
November 5, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27668982/differences-in-symptom-distress-based-on-gender-and-palliative-care-designation-among-hospitalized-patients
#16
Hanna Falk, Ingela Henoch, Anneli Ozanne, Joakim Öhlen, Eva Jakobsson Ung, Isabell Fridh, Elisabeth Kenne Sarenmalm, Kristin Falk
PURPOSE: To explore patient-reported symptom distress in relation to documentation of symptoms and palliative care designation in hospital inpatients. DESIGN: This cross-sectional study analyzed data from 710 inpatients at two large hospitals in Sweden using the Edmonton Symptom Assessment Scale and the Memorial Symptom Assessment Scale. Chart reviews focused on nurses' and physicians' symptom documentation and palliative turning point. METHODS: Descriptive statistics were calculated for all variables and provided summaries about the sample...
September 26, 2016: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/27668841/rapid-response-teams-is-it-time-to-reframe-the-questions-of-rapid-response-team-measurement
#17
Gail G Salvatierra, Ruth C Bindler, Kenn B Daratha
PURPOSE: The purpose of this article is to present an overview of rapid response team (RRT) history in the United States, provide a review of prior RRT effectiveness research, and propose the reframing of four new questions of RRT measurement that are designed to better understand RRTs in the context of contemporary nursing practice as well as patient outcomes. ORGANIZING CONSTRUCT: RRTs were adopted in the United States because of their intuitive appeal, and despite a lack of evidence for their effectiveness...
September 26, 2016: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/27661705/thermal-conductivity-of-the-one-dimensional-fermi-hubbard-model
#18
C Karrasch, D M Kennes, F Heidrich-Meisner
We study the thermal conductivity of the one-dimensional Fermi-Hubbard model at a finite temperature using a density matrix renormalization group approach. The integrability of this model gives rise to ballistic thermal transport. We calculate the temperature dependence of the thermal Drude weight at half filling for various interaction strengths. The finite-frequency contributions originating from the fact that the energy current is not a conserved quantity are investigated as well. We report evidence that breaking the integrability through a nearest-neighbor interaction leads to vanishing Drude weights and diffusive energy transport...
September 9, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27658333/st-segment-elevation-myocardial-infarction-in-a-young-female-consider-spontaneous-peripartum-coronary-artery-dissection
#19
Kenn Ghaffarian, Molly Furin, Robert Bassett
No abstract text is available yet for this article.
August 31, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27645300/structures-and-gene-clusters-of-the-o-specific-polysaccharides-of-the-lipopolysaccharides-of-escherichia-coli-o69-and-o146-containing-glycolactilic-acids-ether-conjugates-of-d-glcnac-and-d-glc-with-r-and-s-lactic-acid
#20
Yuriy A Knirel, Xi Guo, Sof'ya N Senchenkova, Andrei V Perepelov, Bin Liu, Alexander S Shashkov
Based on the O-specific polysaccharides of the lipopolysaccharides (O-polysaccharides, O-antigens), strains of a clonal species Escherichia coli are classified into 184 O serogroups. In this work, structures of the O-polysaccharides of E. coli O69 and O146 were elucidated and gene clusters for their biosynthesis were characterized. The O-polysaccharides were released from the lipopolysaccharides by mild acid hydrolysis and studied by sugar analysis and one- and two-dimensional (1)H and (13)C NMR spectroscopy before and after O-deacetylation...
September 19, 2016: Glycoconjugate Journal
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