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https://www.readbyqxmd.com/read/29135646/foot-structure-and-function-in-habitually-barefoot-and-shod-adolescents-in-kenya
#1
Herje Aibast, Paul Okutoyi, Timothy Sigei, Walter Adero, Danny Chemjor, Neford Ongaro, Noriyuki Fuku, Kenn Konstabel, Carol Clark, Daniel E Lieberman, Yannis Pitsiladis
Habitually barefoot (HB) children from the Kalenjin tribe of Kenya are known for their high physical activity levels. To date, there has been no comprehensive assessment of foot structure and function in these highly active and HB children/adolescents and link with overuse injuries. PURPOSE: The aim of this research is to assess foot structure, foot function, injury and physical activity levels in Kenyan children and adolescents who are HB compared with those who were habitually shod (HS)...
November 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/29100391/gene-expression-information-improves-reliability-of-receptor-status-in-breast-cancer-patients
#2
Michael Kenn, Karin Schlangen, Dan Cacsire Castillo-Tong, Christian F Singer, Michael Cibena, Heinz Koelbl, Wolfgang Schreiner
Immunohistochemical (IHC) determination of receptor status in breast cancer patients is frequently inaccurate. Since it directs the choice of systemic therapy, it is essential to increase its reliability. We increase the validity of IHC receptor expression by additionally considering gene expression (GE) measurements. Crisp therapeutic decisions are based on IHC estimates, even if they are borderline reliable. We further improve decision quality by a responsibility function, defining a critical domain for gene expression...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29060339/an-extended-kalman-filter-with-inequality-constraints-for-real-time-detection-of-intradialytic-hypotension
#3
Sardar Ansari, Somayeh Molaei, Kenn Oldham, Michael Heung, Kevin R Ward, Kayvan Najarian
Intradialytic hypotension (IDH) is the most common complication of hemodialysis, affecting 15-50% of all dialysis sessions. Previously, we had presented a non-invasive Polyvinylidene Fluoride (PVDF) based sensor in the form of a ring to measure vascular tone and we showed that the morphology of the signal can be utilized to predict IDH. This paper presents an approach for analyzing the PVDF signal using extended Kalman filter (EKF) and a synthetic model that has previously been used to model the ECG signal with Gaussian functions...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29048538/improvement-of-foxp3-stability-through-cns2-demethylation-by-tet-enzyme-induction-and-activation
#4
Kazue Someya, Hiroko Nakatsukasa, Minako Ito, Taisuke Kondo, Kenn-Ichi Tateda, Takashi Akanuma, Ikuko Koya, Tsukasa Sanosaka, Jun Kohyama, Yu-Ichi Tsukada, Takeji Takamura-Enya, Akihiko Yoshimura
Since induced regulatory T cells (iTregs) can be produced in a large quantity in vitro, these cells are expected to be clinically useful to induce immunological tolerance in various immunological diseases. Foxp3 (Forkhead box P3) expression in iTregs is, however, unstable due to the lack of demethylation of the CpG island in the conserved non-coding sequence 2 (CNS2) of the Foxp3 locus. To facilitate the demethylation of CNS2, we over-expressed the catalytic domain (CD) of the ten-eleven translocation (TET) protein, which catalyzes the steps of the iterative demethylation of 5-methylcytosine...
August 1, 2017: International Immunology
https://www.readbyqxmd.com/read/29032408/the-natural-history-of-depressive-symptoms-in-patients-with-incident-parkinson-s-disease-a-prospective-cohort-study
#5
Jan Petter Larsen, Ingvild Dalen, Kenn Freddy Pedersen, Ole-Bjørn Tysnes
Depression is common in patients with Parkinson disease and causes suffering and increased caregiver burden. A better understanding of depressive symptoms in Parkinson disease, their progression, and risk factors may, therefore, benefit management of these patients. The present study included 187 drug-naïve patients with incident PD and 166 controls from the population-based Norwegian ParkWest project. Depressive symptoms were examined with the Montgomery and Aasberg Depression Rating Scale (MADRS) at time of diagnosis and inclusion in the study and after 1, 3, 5, and 7 years of follow-up...
October 14, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29027822/mucosa-associated-lymphoid-tissue-lymphoma-with-intraocular-and-orbital-involvement-case-presentation-and-review-of-the-literature
#6
Kenn Freedman, Sudhir Shenoy
Primary ocular lymphomas are typically confined to either the eye or the orbit. Rarely, in immune-competent patients, lymphomas affect both the eye and the orbit simultaneously. Mucosa-associated lymphoid tissue (MALT) lymphomas are the most common ocular lymphomas. They usually present primarily in the orbit but sometimes can present primarily in intraocular tissue. MALT lymphomas that occur initially in the uvea can sometimes spread to the adjacent orbit. We report a case of progressively enlarging MALT lymphoma in a 62-year-old immune-competent patient causing a severe mass effect in the orbit and simultaneously presenting with intraocular involvement...
October 13, 2017: Orbit
https://www.readbyqxmd.com/read/28982206/-in-exchange-with-copd-patients-towards-a-patient-oriented-communication
#7
N M Stenzel, K Kenn, G Steinkamp
The quality of life can be severely impaired in patients with COPD. In addition to physical restraints, they often suffer from psychological comorbidities (e. g. anxiety, depression). Psychological comorbidities are often associated with dysfunctional beliefs about the illness and its treatment. Such dysfunctional beliefs, in turn, are likely to negatively affect patients' quality of life as well as their communication with physicians and their illness behavior in general. It is therefore important for physicians to adapt their communication to account for patients' dysfunctional beliefs...
October 5, 2017: Pneumologie
https://www.readbyqxmd.com/read/28979131/the-use-of-substances-other-than-nicotine-in-electronic-cigarettes-among-college-students
#8
Deric R Kenne, Rebecca L Fischbein, Andy Sl Tan, Mark Banks
INTRODUCTION: Electronic cigarettes (e-cigarettes) have grown in popularity, especially among youth and young adults. Although e-cigarettes were originally intended to vaporize a liquid mixture containing nicotine, there appears to be an increasing trend in other substance use in e-cigarettes (OSUE). MATERIALS AND METHODS: Cross-sectional data from 1542 undergraduate college student e-cigarette users from a large Midwestern university were collected via online survey to assess prevalence of e-cigarette use, reasons for use, perceived harm, and prevalence and predictors of OSUE...
2017: Substance Abuse: Research and Treatment
https://www.readbyqxmd.com/read/28950214/advantages-of-a-validated-uplc-ms-ms-standard-addition-method-for-the-quantification-of-a-type-dimeric-and-trimeric-proanthocyanidins-in-cranberry-extracts-in-comparison-with-well-known-quantification-methods
#9
Ines van Dooren, Kenn Foubert, Mart Theunis, Tania Naessens, Luc Pieters, Sandra Apers
The berries of Vaccinium macrocarpon, cranberry, are widely used for the prevention of urinary tract infections. This species contains A-type proanthocyanidins (PACs), which intervene in the initial phase of the development of urinary tract infections by preventing the adherence of Escherichia coli by their P-type fimbriae to uroepithelial cells. Unfortunately, the existing clinical studies used different cranberry preparations, which were poorly standardized. Because of this, the results were hard to compare, which led sometimes to conflicting results...
September 9, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28900858/methodological-aspects-in-studies-based-on-clinical-routine-data
#10
REVIEW
Lieven Nils Kennes
Randomized controlled clinical trials are regarded as the gold standard for comparing different clinical interventions, but generally their conduct is operationally cumbersome, time-consuming, and expensive. Studies and investigations based on clinical routine data on the contrary utilize existing data acquired under real-life conditions and are increasingly popular among practitioners. In this paper, methodological aspects of studies based on clinical routine data are discussed. Important limitations and considerations as well as unique strengths of these types of studies are indicated and exemplarily demonstrated in a recent real-case study based on clinical routine data...
October 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28853187/time-motion-analysis-of-nursing-work-in-icu-telemetry-and-medical-surgical-units
#11
Elizabeth Schenk, Ruth Schleyer, Cami R Jones, Sarah Fincham, Kenn B Daratha, Karen A Monsen
AIM: This study examined nurses' work, comparing nursing interventions and locations across three units in a United States hospital using Omaha System standardized terminology as the organizing framework. BACKGROUND: The differences in nurses' acute-care work across unit types are not well understood. Prior investigators have used time-motion methodologies; few have compared differences across units, nor used standardized terminology. METHODS: Nurse-observers recorded locations and interventions of nurses on three acute-care units using hand-held devices and web-based TimeCaT(™) software...
August 29, 2017: Journal of Nursing Management
https://www.readbyqxmd.com/read/28851778/seroprevalence-of-hepatitis-c-virus-infection-in-cameroon-a-systematic-review-and-meta-analysis
#12
Jean Joel Bigna, Marie A Amougou, Serra Lem Asangbeh, Angeladine Malaha Kenne, Jobert Richie Nansseu
OBJECTIVE: Better knowledge of hepatitis C virus (HCV) seroprevalence at the national level can help to implement pertinent strategies to address the HCV-related burden. The aim of this paper was to estimate the seroprevalence of HCV infection in Cameroon. DESIGN: Systematic review and meta-analysis. PARTICIPANTS: People residing in Cameroon. DATA SOURCES: Electronic databases including PubMed/MEDLINE, AJOL, WHO-Afro Library, Africa Index Medicus, National Institute of Statistics and National AIDS Control Committee, Cameroon from 1 January 2000 to 15 December 2016 were searched...
August 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28835177/organic-loading-rate-olr-effect-in-the-acidogenesis-of-cheese-whey-uasb-and-an-sbr-reactors-comparison
#13
R Calero, R Iglesias-Iglesias, M C Veiga, C Kennes
Volatile fatty acid (VFA) production and degree acidification (DA) were investigated in the anaerobic treatment of cheese whey (CW) by comparison of two processes, a continuous process using a laboratory Upflow Anaerobic Sludge Blanket (UASB) and discontinuous process using a Sequencing Batch Reactor (SBR). The main purpose of this work was the study of the organic loading rate (OLR) effect on the capacity to obtain the maximum yield of VFA in the two kinds of reactor. The predominant products in the acidogenic process in both reactors were: acetate, propionate, butyrate and valerate...
August 23, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28804091/hodgkin-s-like-lymphoma-in-a-ferret-mustela-putorius-furo
#14
Isao Matsumoto, Kazuyuki Uchida, James Kenn Chambers, Kazumi Nibe, Yu Sato, Taku Hamasu, Hiroyuki Nakayama
A 7-year-old castrated male ferret developed unilateral cervical lymphadenomegaly over a 1-month period. Histological examination revealed proliferation of tumor cells in a diffuse and partially nodular pattern. The tumor cells were predominantly Hodgkin cells and binucleated Reed-Sternberg cells, characterized by abundant, clear, vacuolated cytoplasm, pleomorphic, ovoid nuclei with thick nuclear membranes and distinct nucleoli. Multinucleated cells, resembling lymphocytic and histiocytic (L&H) cells, were also observed...
October 7, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28803105/glucose-bioconversion-profile-in-the-syngas-metabolizing-species-clostridium-carboxidivorans
#15
Ánxela Fernández-Naveira, María C Veiga, Christian Kennes
Some clostridia produce alcohols (ethanol, butanol, hexanol) from gases (CO, CO2, H2) and others from carbohydrates (e.g., glucose). C. carboxidivorans can metabolize both gases as well as glucose. However, its bioconversion profile on glucose had not been reported. It was observed that C. carboxidivorans does not follow a typical solventogenic stage when grown on glucose. Indeed, at pH 6.2, it produced first a broad range of acids (acetic, butyric, hexanoic, formic, and lactic acids), several of which are generally not found, under similar conditions, during gas fermentation...
November 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28800630/measuring-single-constructs-by-single-items-constructing-an-even-shorter-version-of-the-short-five-personality-inventory
#16
Kenn Konstabel, Jan-Erik Lönnqvist, Sointu Leikas, Regina García Velázquez, Hiaying Qin, Markku Verkasalo, Gari Walkowitz
The aim of this study was to construct a short, 30-item personality questionnaire that would be, in terms of content and meaning of the scores, as comparable as possible with longer, well-established inventories such as NEO PI-R and its clones. To do this, we shortened the formerly constructed 60-item "Short Five" (S5) by half so that each subscale would be represented by a single item. We compared all possibilities of selecting 30 items (preserving balanced keying within each domain of the five-factor model) in terms of correlations with well-established scales, self-peer correlations, and clarity of meaning, and selected an optimal combination for each domain...
2017: PloS One
https://www.readbyqxmd.com/read/28781131/muscle-weakness-in-rheumatoid-arthritis-the-role-of-ca-2-and-free-radical-signaling
#17
REVIEW
Takashi Yamada, Maarten M Steinz, Ellinor Kenne, Johanna T Lanner
In addition to the primary symptoms arising from inflammatory processes in the joints, muscle weakness is commonly reported by patients with rheumatoid arthritis (RA). Muscle weakness not only reduces the quality of life for the affected patients, but also dramatically increases the burden on society since patients' work ability decreases. A 25-70% reduction in muscular strength has been observed in pateints with RA when compared with age-matched healthy controls. The reduction in muscle strength is often larger than what could be explained by the reduction in muscle size in patients with RA, which indicates that intracellular (intrinsic) muscle dysfunction plays an important role in the underlying mechanism of muscle weakness associated with RA...
September 2017: EBioMedicine
https://www.readbyqxmd.com/read/28772020/interplay-between-lactobacillus-rhamnosus-gg-and-candida-and-the-involvement-of-exopolysaccharides
#18
Camille N Allonsius, Marianne F L van den Broek, Ilke De Boeck, Shari Kiekens, Eline F M Oerlemans, Filip Kiekens, Kenn Foubert, Dieter Vandenheuvel, Paul Cos, Peter Delputte, Sarah Lebeer
A number of clinical studies have shown protective effects of lactobacilli against Candida species in the gastrointestinal tract, the urogenital tract and the oral cavity, while others did not show clear effects. Evidence on the mode of action of lactobacilli against Candida is also still lacking. In this study, the anti-Candida activity of the model probiotic strain Lactobacillus rhamnosus GG was explored in different assays to determine molecular interactions. We found that L. rhamnosus GG was able to interfere with Candida growth, morphogenesis and adhesion...
November 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28712942/structure-based-discovery-of-clinically-approved-drugs-as-zika-virus-ns2b-ns3-protease-inhibitors-that-potently-inhibit-zika-virus-infection-in%C3%A2-vitro-and-in%C3%A2-vivo
#19
Shuofeng Yuan, Jasper Fuk-Woo Chan, Helena den-Haan, Kenn Ka-Heng Chik, Anna Jinxia Zhang, Chris Chung-Sing Chan, Vincent Kwok-Man Poon, Cyril Chik-Yan Yip, Winger Wing-Nga Mak, Zheng Zhu, Zijiao Zou, Kah-Meng Tee, Jian-Piao Cai, Kwok-Hung Chan, Jorge de la Peña, Horacio Pérez-Sánchez, José Pedro Cerón-Carrasco, Kwok-Yung Yuen
Zika virus (ZIKV) infection may be associated with severe complications in fetuses and adults, but treatment options are limited. We performed an in silico structure-based screening of a large chemical library to identify potential ZIKV NS2B-NS3 protease inhibitors. Clinically approved drugs belonging to different drug classes were selected among the 100 primary hit compounds with the highest predicted binding affinities to ZIKV NS2B-NS3-protease for validation studies. ZIKV NS2B-NS3 protease inhibitory activity was validated in most of the selected drugs and in vitro anti-ZIKV activity was identified in two of them (novobiocin and lopinavir-ritonavir)...
July 14, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28706777/using-community-based-participatory-research-and-organizational-diagnosis-to-characterize-relationships-between-community-leaders-and-academic-researchers
#20
Karen H Wang, Natasha J Ray, David N Berg, Ann T Greene, Georgina Lucas, Kenn Harris, Amy Carroll-Scott, Barbara Tinney, Marjorie S Rosenthal
Sustaining collaborations between community-based organization leaders and academic researchers in community-engaged research (CEnR) in the service of decreasing health inequities necessitates understanding the collaborations from an inter-organizational perspective. We assessed the perspectives of community leaders and university-based researchers conducting community-engaged research in a medium-sized city with a history of community-university tension. Our research team, included experts in CEnR and organizational theory, used qualitative methods and purposeful, snowball sampling to recruit local participants and performed key informant interviews from July 2011-May 2012...
September 2017: Preventive Medicine Reports
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