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https://www.readbyqxmd.com/read/28435315/retrospective-analyses-versus-rcts-comparing-like-with-like
#1
COMMENT
Ralf Baron, Lieven Nils Kennes, Christian Elling
No abstract text is available yet for this article.
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28427544/what-s-the-secret-behind-the-benefits-of-whole-body-vibration-training-in-patients-with-copd-a-randomized-controlled-trial
#2
Rainer Gloeckl, Inga Jarosch, Ulrike Bengsch, Magdalena Claus, Tessa Schneeberger, Vasileios Andrianopoulos, Jeffrey W Christle, Wolfgang Hitzl, Klaus Kenn
BACKGROUND: Several studies have shown that whole-body vibration training (WBVT) improves exercise capacity in patients with severe COPD. The aim of this study was to investigate the determinants of improved exercise capacity following WBVT. METHODS: Seventy-four COPD patients (FEV1: 34 ± 9%predicted) were recruited during a 3-week inpatient pulmonary rehabilitation (PR) program. Conventional endurance and strength exercises were supplemented with self-paced dynamic squat training sessions (4bouts*2min, 3times/wk)...
May 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28421677/mindfulness-and-its-efficacy-for-psychological-and-biological-responses-in-women-with-breast-cancer
#3
Elisabeth Kenne Sarenmalm, Lena B Mårtensson, Bengt A Andersson, Per Karlsson, Ingrid Bergh
Many breast cancer survivors have to deal with a variety of psychological and physiological sequelae including impaired immune responses. The primary purpose of this randomized controlled trial was to determine the efficacy of a mindfulness-based stress reduction (MBSR) intervention for mood disorders in women with breast cancer. Secondary outcomes were symptom experience, health status, coping capacity, mindfulness, posttraumatic growth, and immune status. This RTC assigned 166 women with breast cancer to one of three groups: MBSR (8 weekly group sessions of MBSR), active controls (self-instructing MBSR) and non-MBSR...
April 18, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28356123/epidemiology-of-chronic-obstructive-pulmonary-disease-in-the-global-hiv-infected-population-a-systematic-review-and-meta-analysis-protocol
#4
Jean Joel R Bigna, Angeladine Malaha Kenne, Serra Lem Asangbeh
BACKGROUND: Evidence suggests a relationship between human immunodeficiency virus (HIV) infection and chronic obstructive pulmonary disease (COPD). Although the high burden of COPD and the HIV disease is clearly demonstrated, to the best of our knowledge, there is a lack of summary and meta-analysis data on the epidemiology of COPD in the global HIV-infected population to date. The present protocol for a systematic review and meta-analysis intends to summarize existing data on the prevalence, incidence, and risk factors of COPD in the global HIV-infected population...
March 29, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28334932/ribosome-dependent-vibrio-cholerae-mrnase-higb2-is-regulated-by-a-%C3%AE-strand-sliding-mechanism
#5
San Hadži, Abel Garcia-Pino, Sarah Haesaerts, Dukas Jurenas, Kenn Gerdes, Jurij Lah, Remy Loris
Toxin-antitoxin (TA) modules are small operons involved in bacterial stress response and persistence. higBA operons form a family of TA modules with an inverted gene organization and a toxin belonging to the RelE/ParE superfamily. Here, we present the crystal structures of chromosomally encoded Vibrio cholerae antitoxin (VcHigA2), toxin (VcHigB2) and their complex, which show significant differences in structure and mechanisms of function compared to the higBA module from plasmid Rts1, the defining member of the family...
February 28, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28329753/benefits-of-high-intensity-exercise-training-to-patients-with-chronic-obstructive-pulmonary-disease-a-controlled-study
#6
Tobias Boeselt, Christoph Nell, Lea Lütteken, Katharina Kehr, Janine Koepke, Sandra Apelt, Martina Veith, Björn Beutel, Marc Spielmanns, Timm Greulich, Claus F Vogelmeier, Klaus Kenn, Sabina Janciauskiene, Peter Alter, A Rembert Koczulla
BACKGROUND: Various exercise training programs are used for patients with chronic obstructive pulmonary disease (COPD) of different severity. OBJECTIVES: To investigate the impact of individualized high-intensity training on exercise capacity with COPD. METHODS: A total of 49 patients agreed to participate. Of these, 31 were assigned to the training group and 18 served as controls. The training group exercised twice a week for 90 min with consecutively increasing loads...
2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28326310/cardiopulmonary-response-during-whole-body-vibration-training-in-patients-with-severe-copd
#7
Rainer Gloeckl, Petra Richter, Sandra Winterkamp, Michael Pfeifer, Christoph Nell, Jeffrey W Christle, Klaus Kenn
Several studies in patients with chronic obstructive pulmonary disease (COPD) have shown that whole-body vibration training (WBVT) has beneficial effects on exercise capacity. However, the acute cardiopulmonary demand during WBVT remains unknown and was therefore investigated in this study. Ten patients with severe COPD (forced expiratory volume in 1 s: 38±8% predicted) were examined on two consecutive days. On day one, symptom-limited cardiopulmonary exercise testing was performed on a cycle ergometer. The next day, six bouts of repeated squat exercises were performed in random order for one, two or three minutes either with or without WBVT while metabolic demands were simultaneously measured...
January 2017: ERJ Open Research
https://www.readbyqxmd.com/read/28322693/influence-of-referral-pathway-on-ebola-virus-disease-case-fatality-rate-and-effect-of-survival-selection-bias
#8
Frauke Rudolf, Mads Damkjær, Suzanne Lunding, Kenn Dornonville de la Cour, Alyssa Young, Tim Brooks, Tom Sesay, Alex P Salam, Sharmistha Mishra, Merete Storgaard
Case-fatality rates in Ebola treatment centers (ETCs) varied widely during the Ebola virus disease (EVD) outbreak in West Africa. We assessed the influence of referral pathway on ETC case-fatality rates with a retrospective cohort of 126 patients treated at the Mathaska ETC in Port Loko, Sierra Leone. The patients consisted of persons who had confirmed EVD when transferred to the ETC or who had been diagnosed onsite. The case-fatality rate for transferred patients was 46% versus 67% for patients diagnosed onsite (p = 0...
April 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28289369/associations-of-attitudes-towards-electronic-cigarettes-with-advertisement-exposure-and-social-determinants-a-cross-sectional-study
#9
Benjamin Reinhold, Rebecca Fischbein, Surya Sruthi Bhamidipalli, Jennifer Bryant, Deric R Kenne
BACKGROUND: The exposure of young adults to electronic cigarette (e-cigarette) advertisements has risen rapidly. E-cigarette ads have been shown to increase short term perceived acceptability of using e-cigarettes in places where traditional cigarettes are banned. We set out to investigate if advertising exposure was related to perceptions of harm, addictiveness, and acceptability of use of e-cigarettes in places where traditional cigarettes are banned. METHODS: Using a cross-sectional design, 6037 students at a large Midwestern university between the ages of 18-24 were surveyed about e-cigarette use and smoking status...
2017: Tobacco Induced Diseases
https://www.readbyqxmd.com/read/28284565/isolation-and-structure-elucidation-of-cyclopeptide-alkaloids-from-ziziphus-nummularia-and-ziziphus-spina-christi-by-hplc-dad-ms-and-hplc-pda-hrms-spe-nmr
#10
Emmy Tuenter, Kenn Foubert, Dan Staerk, Sandra Apers, Luc Pieters
Seven cyclopeptide alkaloids were isolated from the stem bark of Ziziphus nummularia and Ziziphus spina-christi. Three previously undescribed compounds were identified: nummularine-U, spinanine-B and spinanine-C, together with the known compounds mauritine-F, nummularine-D, nummularine-E and amphibine-D. For their purification either semi-preparative HPLC with DAD and ESIMS detection or HPLC-PDA-(HRMS)-SPE-NMR was applied, together with conventional separation methods. Their structures were elucidated by spectroscopic means...
March 8, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28266056/hica-toxin-of-escherichia-coli-derepresses-hicab-transcription-to-selectively-produce-hicb-antitoxin
#11
Kathryn J Turnbull, Kenn Gerdes
Antitoxins encoded by type II toxin - antitoxin (TA) modules neutralize cognate toxins by direct protein - protein contact and in addition, regulate TA operon transcription by binding to operators in the promoter regions. On top of the simple negative feed-back regulation, canonical type II TA operons are regulated by a mechanism called "Conditional Cooperativity" (CC). In CC, the cellular toxin:antitoxin (T:A) ratio controls the transcription-rate such that low T:A ratios favour repression and high T:A ratios favour de-repression of TA operon transcription...
March 7, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28215984/the-cost-of-nurse-midwifery-care-use-of-interventions-resources-and-associated-costs-in-the-hospital-setting
#12
Molly R Altman, Sean M Murphy, Cynthia E Fitzgerald, H Frank Andersen, Kenn B Daratha
INTRODUCTION: Obstetrical care often involves multiple expensive, and often elective, interventions that may increase costs to patients, payers and the health care system with little effect on patient outcomes. The objectives of this study were to examine the following hospital related outcomes: 1) use of labor and birth interventions, 2) inpatient duration of stay, and 3) total direct health care costs for patients attended by a certified nurse-midwife (CNM) compared with those attended by an obstetrician-gynecologist (OB-GYN), within an environment of safe and high-quality care...
February 15, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28214373/improved-detection-of-zika-virus-rna-in-human-and-animal-specimens-by-a-novel-highly-sensitive-and-specific-real-time-rt-pcr-assay-targeting-the-5-untranslated-region-of-zika-virus
#13
Jasper Fuk-Woo Chan, Cyril Chik-Yan Yip, Kah-Meng Tee, Zheng Zhu, Jessica Oi-Ling Tsang, Kenn Ka-Heng Chik, Terance Gi-Wai Tsang, Chris Chung-Sing Chan, Vincent Kwok-Man Poon, Siddharth Sridhar, Feifei Yin, Ivan Fan-Ngai Hung, Sandy Ka-Yee Chau, Anna Jinxia Zhang, Kwok-Hung Chan, Kwok-Yung Yuen
OBJECTIVE AND METHOD: We developed and evaluated five novel real-time RT-PCR assays targeting conserved regions in the 5'-untranslated region (5'-UTR), envelope (E'), non-structural protein 2A (NS2A), NS5, and 3'-UTR of the ZIKV genome. RESULTS: The ZIKV-5'-UTR assay exhibited the lowest in-vitro limit of detection (5-10 RNA copies/reaction and 3.0×10(-1) plaque-forming units/ml). Compared to the modified version of a widely adopted RT-PCR assay targeting the ZIKV-E gene, the ZIKV-5'-UTR assay showed better sensitivity in human clinical specimens, and representative mouse specimens, including many organs which are known to be involved in human ZIKV infection but difficult to obtain in clinical settings...
February 18, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28211687/isolation-and-structure-elucidation-of-glucosylated-colchicinoids-from-the-seeds-of-gloriosa-superba-by-lc-dad-spe-nmr
#14
Yancho Zarev, Kenn Foubert, Iliana Ionkova, Sandra Apers, Luc Pieters
Four new colchicinoids were isolated from the seeds of Gloriosa superba together with the known compounds colchicoside (4) and 3-de-O-methylcolchicine-3-O-β-d-glucopyranosyl-(1→4)-3-O-β-d-glucopyranoside (6), by means of conventional column chromatography and LC-DAD-SPE-NMR. The new compounds were identified as N-deacetyl-N-formyl-3-de-O-methylcolchicine-3-O-β-d-glucopyranoside (1), 3-de-O-methylcolchicine-3-O-β-d-glucopyranosyl-(1→6)-3-O-β-d-glucopyranoside (2), N-deacetyl-N-formyl-3-de-O-methylcolchicine-3-O-β-d-glucopyranosyl-(1→6)-3-O-β-d-glucopyranoside (3), and 3-de-O-methylcolchicine-3-O-β-d-glucopyranosyl-(1→3)-3-O-β-d-glucopyranoside (5)...
February 17, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28202373/is-fatigue-associated-with-cognitive-dysfunction-in-early-parkinson-s-disease
#15
Benzi M Kluger, Kenn Freddy Pedersen, Ole-Bjorn Tysnes, Solgunn O Ongre, Bjørg Øygarden, Karen Herlofson
INTRODUCTION: Fatigue is a common and disabling symptom which may be seen in early Parkinson's disease (PD). Our understanding of the phenomenology and etiology of fatigue in PD is limited. The objective of this study was to determine whether fatigue was related to cognition in early PD patients. METHODS: The study is part of the Norwegian ParkWest project, a population-based cohort study, comprising 184 de novo, drug-naïve patients with PD. PD was diagnosed according to the Gelb criteria...
February 7, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28185815/novel-antiviral-activity-and-mechanism-of-bromocriptine-as-a-zika-virus-ns2b-ns3-protease-inhibitor
#16
Jasper Fuk-Woo Chan, Kenn Ka-Heng Chik, Shuofeng Yuan, Cyril Chik-Yan Yip, Zheng Zhu, Kah-Meng Tee, Jessica Oi-Ling Tsang, Chris Chung-Sing Chan, Vincent Kwok-Man Poon, Gang Lu, Anna Jinxia Zhang, Kin-Kui Lai, Kwok-Hung Chan, Richard Yi-Tsun Kao, Kwok-Yung Yuen
Zika virus (ZIKV) infection is associated with congenital malformations in infected fetuses and severe neurological and other systemic complications in adults. There are currently limited anti-ZIKV treatment options that are readily available and safe for use in pregnancy. In this drug repurposing study, bromocriptine was found to have inhibitory effects on ZIKV replication in cytopathic effect inhibition, virus yield reduction, and plaque reduction assays. Time-of-drug-addition assay showed that bromocriptine exerted anti-ZIKV activity between 0 and 12 h post-ZIKV inoculation, corroborating with post-entry events in the virus replication cycle prior to budding...
May 2017: Antiviral Research
https://www.readbyqxmd.com/read/28164379/peptide-nucleotide-antibiotic-microcin-c-is-a-potent-inducer-of-stringent-response-and-persistence-in-both-sensitive-and-producing-cells
#17
Julia Piskunova, Etienne Maisonneuve, Elsa Germain, Kenn Gerdes, Konstantin Severinov
Microcin C (McC) is a peptide-nucleotide antibiotic that inhibits aspartyl-tRNA synthetase. Here, we show that McC is a strong inducer of persistence in Escherichia coli. Persistence induced by McC is mediated by (p)ppGpp and requires chromosomally encoded toxin-antitoxin modules. McC-producing cells have increased persistence levels due to a combined effect of McC imported from the cultured medium and intracellularly synthesized antibiotic. McC-producing cells also induce persistence in sensitive cells during co-cultivation, underscoring complex interactions in bacterial communities where an antagonistic compound produced by one community member can benefit other members by increasing their ability to withstand antibiotics...
February 6, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28160118/production-of-chemicals-from-c1-gases-co-co2-by-clostridium-carboxidivorans
#18
REVIEW
Ánxela Fernández-Naveira, Haris Nalakath Abubackar, María C Veiga, Christian Kennes
Bioprocesses in conventional second generation biorefineries are mainly based on the fermentation of sugars obtained from lignocellulosic biomass or agro-industrial wastes. An alternative to this process consists in gasifying those same feedstocks or even other carbon-containing materials to obtain syngas which can also be fermented by some anaerobic bacteria to produce chemicals or fuels. Carbon monoxide, carbon dioxide and hydrogen, which are the main components of syngas, are also found in some industrial waste gases, among others in steel industries...
March 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28152554/in-vitro-and-in-vivo-study-of-the-gastrointestinal-absorption-and-metabolisation-of-hymenocardine-a-cyclopeptide-alkaloid
#19
Emmy Tuenter, Sebastiaan Bijttebier, Kenn Foubert, Annelies Breynaert, Sandra Apers, Nina Hermans, Luc Pieters
Hymenocardine is a cyclopeptide alkaloid present in the root bark of Hymenocardia acida. In traditional African medicine, the leaves and roots of this plant are used to treat malaria, and moderate in vitro antiplasmodial activity has been reported for hymenocardine. However, in view of its peptide-like nature, potential metabolisation after oral ingestion has to be taken into account when considering in vivo experiments. In this study, the stability and small intestinal absorption of hymenocardine was assessed using an in vitro gastrointestinal dialysis model...
February 2, 2017: Planta Medica
https://www.readbyqxmd.com/read/28127922/excess-mortality-in-persons-with-severe-mental-disorders-a-multilevel-intervention-framework-and-priorities-for-clinical-practice-policy-and-research-agendas
#20
Nancy H Liu, Gail L Daumit, Tarun Dua, Ralph Aquila, Fiona Charlson, Pim Cuijpers, Benjamin Druss, Kenn Dudek, Melvyn Freeman, Chiyo Fujii, Wolfgang Gaebel, Ulrich Hegerl, Itzhak Levav, Thomas Munk Laursen, Hong Ma, Mario Maj, Maria Elena Medina-Mora, Merete Nordentoft, Dorairaj Prabhakaran, Karen Pratt, Martin Prince, Thara Rangaswamy, David Shiers, Ezra Susser, Graham Thornicroft, Kristian Wahlbeck, Abe Fekadu Wassie, Harvey Whiteford, Shekhar Saxena
Excess mortality in persons with severe mental disorders (SMD) is a major public health challenge that warrants action. The number and scope of truly tested interventions in this area remain limited, and strategies for implementation and scaling up of programmes with a strong evidence base are scarce. Furthermore, the majority of available interventions focus on a single or an otherwise limited number of risk factors. Here we present a multilevel model highlighting risk factors for excess mortality in persons with SMD at the individual, health system and socio-environmental levels...
February 2017: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
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