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https://www.readbyqxmd.com/read/28900858/methodological-aspects-in-studies-based-on-clinical-routine-data
#1
REVIEW
Lieven Nils Kennes
Randomized controlled clinical trials are regarded as the gold standard for comparing different clinical interventions, but generally their conduct is operationally cumbersome, time-consuming, and expensive. Studies and investigations based on clinical routine data on the contrary utilize existing data acquired under real-life conditions and are increasingly popular among practitioners. In this paper, methodological aspects of studies based on clinical routine data are discussed. Important limitations and considerations as well as unique strengths of these types of studies are indicated and exemplarily demonstrated in a recent real-case study based on clinical routine data...
September 12, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28853187/time-motion-analysis-of-nursing-work-in-icu-telemetry-and-medical-surgical-units
#2
Elizabeth Schenk, Ruth Schleyer, Cami R Jones, Sarah Fincham, Kenn B Daratha, Karen A Monsen
AIM: This study examined nurses' work, comparing nursing interventions and locations across three units in a United States hospital using Omaha System standardized terminology as the organizing framework. BACKGROUND: The differences in nurses' acute-care work across unit types are not well understood. Prior investigators have used time-motion methodologies; few have compared differences across units, nor used standardized terminology. METHODS: Nurse-observers recorded locations and interventions of nurses on three acute-care units using hand-held devices and web-based TimeCaT(™) software...
August 29, 2017: Journal of Nursing Management
https://www.readbyqxmd.com/read/28851778/seroprevalence-of-hepatitis-c-virus-infection-in-cameroon-a-systematic-review-and-meta-analysis
#3
Jean Joel Bigna, Marie A Amougou, Serra Lem Asangbeh, Angeladine Malaha Kenne, Jobert Richie Nansseu
OBJECTIVE: Better knowledge of hepatitis C virus (HCV) seroprevalence at the national level can help to implement pertinent strategies to address the HCV-related burden. The aim of this paper was to estimate the seroprevalence of HCV infection in Cameroon. DESIGN: Systematic review and meta-analysis. PARTICIPANTS: People residing in Cameroon. DATA SOURCES: Electronic databases including PubMed/MEDLINE, AJOL, WHO-Afro Library, Africa Index Medicus, National Institute of Statistics and National AIDS Control Committee, Cameroon from 1 January 2000 to 15 December 2016 were searched...
August 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28835177/organic-loading-rate-olr-effect-in-the-acidogenesis-of-cheese-whey-uasb-and-an-sbr-reactors-comparison
#4
R Calero, R Iglesias-Iglesias, M C Veiga, C Kennes
Volatile fatty acid (VFA) production and degree acidification (DA) were investigated in the anaerobic treatment of cheese whey (CW) by comparison of two processes, a continuous process using a laboratory Upflow Anaerobic Sludge Blanket (UASB) and discontinuous process using a Sequencing Batch Reactor (SBR). The main purpose of this work was the study of the organic loading rate (OLR) effect on the capacity to obtain the maximum yield of VFA in the two kinds of reactor. The predominant products in the acidogenic process in both reactors were: acetate, propionate, butyrate and valerate...
August 23, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28804091/hodgkin-s-like-lymphoma-in-a-ferret-mustela-putorius-furo
#5
Isao Matsumoto, Kazuyuki Uchida, James Kenn Chambers, Kazumi Nibe, Yu Sato, Taku Hamasu, Hiroyuki Nakayama
A 7-year-old castrated male ferret developed unilateral cervical lymphadenomegaly over a 1-month period. Histological examination revealed proliferation of tumor cells in a diffuse and partially nodular pattern. The tumor cells were predominantly Hodgkin cells and binucleated Reed-Sternberg cells, characterized by abundant, clear, vacuolated cytoplasm, pleomorphic, ovoid nuclei with thick nuclear membranes and distinct nucleoli. Multinucleated cells, resembling lymphocytic and histiocytic (L&H) cells, were also observed...
August 11, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28803105/glucose-bioconversion-profile-in-the-syngas-metabolizing-species-clostridium-carboxidivorans
#6
Ánxela Fernández-Naveira, María C Veiga, Christian Kennes
Some clostridia produce alcohols (ethanol, butanol, hexanol) from gases (CO, CO2, H2) and others from carbohydrates (e.g., glucose). C. carboxidivorans can metabolize both gases as well as glucose. However, its bioconversion profile on glucose had not been reported. It was observed that C. carboxidivorans does not follow a typical solventogenic stage when grown on glucose. Indeed, at pH 6.2, it produced first a broad range of acids (acetic, butyric, hexanoic, formic, and lactic acids), several of which are generally not found, under similar conditions, during gas fermentation...
November 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28800630/measuring-single-constructs-by-single-items-constructing-an-even-shorter-version-of-the-short-five-personality-inventory
#7
Kenn Konstabel, Jan-Erik Lönnqvist, Sointu Leikas, Regina García Velázquez, Hiaying Qin, Markku Verkasalo, Gari Walkowitz
The aim of this study was to construct a short, 30-item personality questionnaire that would be, in terms of content and meaning of the scores, as comparable as possible with longer, well-established inventories such as NEO PI-R and its clones. To do this, we shortened the formerly constructed 60-item "Short Five" (S5) by half so that each subscale would be represented by a single item. We compared all possibilities of selecting 30 items (preserving balanced keying within each domain of the five-factor model) in terms of correlations with well-established scales, self-peer correlations, and clarity of meaning, and selected an optimal combination for each domain...
2017: PloS One
https://www.readbyqxmd.com/read/28781131/muscle-weakness-in-rheumatoid-arthritis-the-role-of-ca-2-and-free-radical-signaling
#8
REVIEW
Takashi Yamada, Maarten M Steinz, Ellinor Kenne, Johanna T Lanner
In addition to the primary symptoms arising from inflammatory processes in the joints, muscle weakness is commonly reported by patients with rheumatoid arthritis (RA). Muscle weakness not only reduces the quality of life for the affected patients, but also dramatically increases the burden on society since patients' work ability decreases. A 25-70% reduction in muscular strength has been observed in pateints with RA when compared with age-matched healthy controls. The reduction in muscle strength is often larger than what could be explained by the reduction in muscle size in patients with RA, which indicates that intracellular (intrinsic) muscle dysfunction plays an important role in the underlying mechanism of muscle weakness associated with RA...
July 26, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28772020/interplay-between-lactobacillus-rhamnosus-gg-and-candida-and-the-involvement-of-exopolysaccharides
#9
Camille N Allonsius, Marianne F L van den Broek, Ilke De Boeck, Shari Kiekens, Eline F M Oerlemans, Filip Kiekens, Kenn Foubert, Dieter Vandenheuvel, Paul Cos, Peter Delputte, Sarah Lebeer
A number of clinical studies have shown protective effects of lactobacilli against Candida species in the gastrointestinal tract, the urogenital tract and the oral cavity, while others did not show clear effects. Evidence on the mode of action of lactobacilli against Candida is also still lacking. In this study, the anti-Candida activity of the model probiotic strain Lactobacillus rhamnosus GG was explored in different assays to determine molecular interactions. We found that L. rhamnosus GG was able to interfere with Candida growth, morphogenesis and adhesion...
August 3, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28712942/structure-based-discovery-of-clinically-approved-drugs-as-zika-virus-ns2b-ns3-protease-inhibitors-that-potently-inhibit-zika-virus-infection-in%C3%A2-vitro-and-in%C3%A2-vivo
#10
Shuofeng Yuan, Jasper Fuk-Woo Chan, Helena den-Haan, Kenn Ka-Heng Chik, Anna Jinxia Zhang, Chris Chung-Sing Chan, Vincent Kwok-Man Poon, Cyril Chik-Yan Yip, Winger Wing-Nga Mak, Zheng Zhu, Zijiao Zou, Kah-Meng Tee, Jian-Piao Cai, Kwok-Hung Chan, Jorge de la Peña, Horacio Pérez-Sánchez, José Pedro Cerón-Carrasco, Kwok-Yung Yuen
Zika virus (ZIKV) infection may be associated with severe complications in fetuses and adults, but treatment options are limited. We performed an in silico structure-based screening of a large chemical library to identify potential ZIKV NS2B-NS3 protease inhibitors. Clinically approved drugs belonging to different drug classes were selected among the 100 primary hit compounds with the highest predicted binding affinities to ZIKV NS2B-NS3-protease for validation studies. ZIKV NS2B-NS3 protease inhibitory activity was validated in most of the selected drugs and in vitro anti-ZIKV activity was identified in two of them (novobiocin and lopinavir-ritonavir)...
July 14, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28706777/using-community-based-participatory-research-and-organizational-diagnosis-to-characterize-relationships-between-community-leaders-and-academic-researchers
#11
Karen H Wang, Natasha J Ray, David N Berg, Ann T Greene, Georgina Lucas, Kenn Harris, Amy Carroll-Scott, Barbara Tinney, Marjorie S Rosenthal
Sustaining collaborations between community-based organization leaders and academic researchers in community-engaged research (CEnR) in the service of decreasing health inequities necessitates understanding the collaborations from an inter-organizational perspective. We assessed the perspectives of community leaders and university-based researchers conducting community-engaged research in a medium-sized city with a history of community-university tension. Our research team, included experts in CEnR and organizational theory, used qualitative methods and purposeful, snowball sampling to recruit local participants and performed key informant interviews from July 2011-May 2012...
September 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28681610/is-it-time-for-child-psychiatry-to-grow-up
#12
Hiran Thabrew, Scott Henderson, Philip Hazell, Stephanie Moor, Nick Kowalenko, Felicity Kenn
No abstract text is available yet for this article.
July 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28667212/seroprevalence-of-hepatitis-b-virus-infection-in-cameroon-a-systematic-review-and-meta-analysis
#13
Jean Joel Bigna, Marie A Amougou, Serra Lem Asangbeh, Angeladine Malaha Kenne, Steve Raoul N Noumegni, Elodie T Ngo-Malabo, Jean Jacques Noubiap
OBJECTIVE: Better knowledge of hepatitis B virus (HBV) infection prevalence at the national level can help to implement pertinent strategies to address HBV related burden. The aim was to estimate the seroprevalence of HBV infection in Cameroon. DESIGN: Systematic review and meta-analysis. PARTICIPANTS: People residing in Cameroon. DATA SOURCES: Electronic databases including PubMed/MEDLINE, African Journals Online (AJOL), ScienceDirect, WHO-Afro Library, WHO-IRIS, African Index Medicus, National Institute of Statistics and National AIDS Control Committee, Cameroon; regardless of language and from 1 January 2000 to 30 September 2016...
June 30, 2017: BMJ Open
https://www.readbyqxmd.com/read/28629710/anaerobic-digestion-of-tuna-waste-for-the-production-of-volatile-fatty-acids
#14
Noela Bermúdez-Penabad, Christian Kennes, Maria C Veiga
Fish canning industries generate a significant amount of solid waste that can be digested anaerobically into volatile fatty acids (VFA). The aim of this research was to study the effect of various pHs, ranging from 5.0 to 10.0, and percentage of total solids on the anaerobic digestion of tuna waste into VFA, both in batch assays and continuous reactor. The production of VFA was affected by pH and was significantly higher under alkaline conditions. At pH 8.0, the VFA production reached 30,611mgCOD/L. The VFA mainly consisted of acetic, propionic, n-butyric and i-valeric acids...
June 16, 2017: Waste Management
https://www.readbyqxmd.com/read/28614730/antigenotoxic-prenylated-flavonoids-from-stem-bark-of-erythrina-latissima
#15
Yancho Zarev, Kenn Foubert, Vera Lucia de Almeida, Roel Anthonissen, Esameldin Elgorashi, Sandra Apers, Iliana Ionkova, Luc Verschaeve, Luc Pieters
A series of prenylated flavonoids was obtained from antigenotoxic extracts and fractions of stem bark of Erythrina latissima E. Mey (Leguminosae). In addition to five constituents never reported before, i.e. (2S)-5,7-dihydroxy-2-(4-hydroxy-2-(prop-1-en-2-yl)-2,3-dihydrobenzofuran-6-yl)chroman-4-one (erylatissin D), (2S)-5,7-dihydroxy-2-(4-methoxy-2-(prop-1-en-2-yl)-2,3-dihydrobenzofuran-6-yl)chroman-4-one (erylatissin E), 5,7-dihydroxy-3-(4-methoxy-2-(prop-1-en-2-yl)-2,3-dihydrobenzofuran-6-yl)-4H-chromen-4-one (erylatissin F), (2S)-5,7,8'-trihydroxy-2',2'-dimethyl-[2,6'-bichroman]-4-one (erylatissin G) and (2S)-5,7-dihydroxy-8'-methoxy-2',2'-dimethyl-[2,6'-bichroman]-4-one (dihydroabyssinin I), 18 known flavonoids were identified...
September 2017: Phytochemistry
https://www.readbyqxmd.com/read/28601868/pulmonary-rehabilitation-outcomes-after-single-or-double-lung-transplantation-in-patients-with-chronic-obstructive-pulmonary-disease-or-interstitial-lung-disease
#16
Tessa Schneeberger, Rainer Gloeckl, Tobias Welte, Klaus Kenn
BACKGROUND: Pulmonary rehabilitation (PR) following lung transplantation (LTx) has been shown to be effective with regard to exercise capacity and health-related quality of life (HRQL). However, outcome data is limited with respect to LTx as a population. Differences concerning the effects of PR in patients with single LTx (SLTx) or double LTx (DLTx) have not been studied yet. OBJECTIVES: The aim was to compare possible differences concerning PR outcomes between SLTx and DLTx...
2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28578818/clinical-milestones-in-parkinson-s-disease-a-7-year-population-based-incident-cohort-study
#17
Anders Bjornestad, Kenn Freddy Pedersen, Ole-Bjorn Tysnes, Guido Alves
INTRODUCTION: Clinical staging of Parkinson's disease (PD) is important for patient management and prognosis. The non-motor and functional features visual hallucinations, recurrent falls, dementia and nursing home placement are currently not included in clinical staging schemes, but have been suggested as clinical milestones with important prognostic implications in advanced PD. In this study, we sought to evaluate the potential of these four milestone events for clinical staging and prognosis during the early years of the disease...
May 29, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28521235/integrated-bioconversion-of-syngas-into-bioethanol-and-biopolymers
#18
Borja Lagoa-Costa, Haris Nalakath Abubackar, María Fernández-Romasanta, Christian Kennes, María C Veiga
Syngas bioconversion is a promising method for bioethanol production, but some VFA remains at the end of fermentation. A two-stage process was set-up, including syngas fermentation as first stage under strict anaerobic conditions using C. autoethanogenum as inoculum, with syngas (CO/CO2/H2/N2, 30/10/20/40) as gaseous substrate. The second stage consisted in various fed-batch assays using a highly enriched PHA accumulating biomass as inoculum, where the potential for biopolymer production from the remaining acetic acid at the end of the syngas fermentation was evaluated...
September 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28514193/90-90-90-plus-maintaining-adherence-to-antiretroviral-therapies
#19
Inge B Corless, Alex J Hoyt, Lynda Tyer-Viola, Elizabeth Sefcik, Jeanne Kemppainen, William L Holzemer, Lucille Sanzero Eller, Kathleen Nokes, J Craig Phillips, Carol Dawson-Rose, Marta Rivero-Mendez, Scholastika Iipinge, Puangtip Chaiphibalsarisdi, Carmen J Portillo, Wei-Ti Chen, Allison R Webel, John Brion, Mallory O Johnson, Joachim Voss, Mary Jane Hamilton, Kathleen M Sullivan, Kenn M Kirksey, Patrice K Nicholas
Medication adherence is the "Plus" in the global challenge to have 90% of HIV-infected individuals tested, 90% of those who are HIV positive treated, and 90% of those treated achieve an undetectable viral load. The latter indicates viral suppression, the goal for clinicians treating people living with HIV (PLWH). The comparative importance of different psychosocial scales in predicting the level of antiretroviral adherence, however, has been little studied. Using data from a cross-sectional study of medication adherence with an international convenience sample of 1811 PLWH, we categorized respondent medication adherence as None (0%), Low (1-60%), Moderate (61-94%), and High (95-100%) adherence based on self-report...
May 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28507520/in-vitro-and-in-silico-antidiabetic-and-antimicrobial-evaluation-of-constituents-from-kickxia-ramosissima-nanorrhinum-ramosissimum
#20
Adnan Amin, Emmy Tuenter, Kenn Foubert, Jamhsed Iqbal, Paul Cos, Louis Maes, Vassiliki Exarchou, Sandra Apers, Luc Pieters
Background and Aims:Kickxia ramosissima (Wall.) Janch (or Nanorrhinum ramosissimum (Wall.) Betsche is a well-known medicinal plant in Pakistan that is traditionally used in diabetic and inflammatory conditions. Because little information is available on its phytochemical composition, a range of constituents were isolated and evaluated in vitro in assays related to the traditional use. Methods: Dried whole plant material was extracted and chromatographically fractionated. Isolated constituents were evaluated in silico and in vitro in assays related to the traditional use against diabetes (inhibition of α-glucosidase activity; inhibition of advanced glycation endproducts) and in inflammatory conditions (inhibition of AAPH induced linoleic acid peroxidation, inhibition of 15-LOX, antimicrobial activity)...
2017: Frontiers in Pharmacology
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