Cassandra E Meyer, Andrew W Smith, Aitana A Padilla-Requerey, Vista Farkhondeh, Noriko Itoh, Yuichiro Itoh, Josephine L Gao, Patrick D Herbig, Quynhanh Nguyen, Katelyn H Ngo, Mandavi R Oberoi, Prabha Siddarth, Rhonda R Voskuhl, Allan MacKenzie-Graham
In multiple sclerosis (MS), demyelination occurs in cerebral cortex, and cerebral cortex atrophy correlates with clinical disabilities. Treatments are needed in MS to induce remyelination. Pregnancy is protective in MS. Estriol is made by the fetoplacental unit, and maternal serum estriol levels temporally align with fetal myelination. Here, we determined the effect of estriol treatment on cerebral cortex in the preclinical model of MS, experimental autoimmune encephalomyelitis (EAE). Estriol treatment initiated after disease onset decreased cerebral cortex atrophy...
May 26, 2023: Laboratory Investigation; a Journal of Technical Methods and Pathology