keyword
MENU ▼
Read by QxMD icon Read
search

fetal neuroprotection

keyword
https://www.readbyqxmd.com/read/29131068/maternal-cannabinoid-use-alters-cannabinoid-cb1-and-endothelin-etb-receptor-expression-in-the-brains-of-dams-but-not-their-offspring
#1
Aarti Amlani, Mary G Hornick, Kevin Cooper, Preetha Prazad, Ramona Donovan, Anil Gulati
According to the 2015 National Survey on Drug Use and Health, cannabis (marijuana) is the most commonly used recreational drug in the US. Among pregnant women aged 14-55 years, 3.4% were cannabis users. Presently, little is known about the neurodevelopmental effect of cannabis use during pregnancy and/or nursing on neonates. Endothelin (ET) is essential for normal development of the central nervous system (CNS). Decreases in ETB receptor expression correlate with a decline in nerve growth factor (NGF) and an increase in vascular endothelial growth factor (VEGF) in postnatal brain...
November 4, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/29113582/the-effects-of-magnesium-sulfate-on-the-inflammatory-response-of-placentas-perfused-with-lipopolysaccharide-using-the-ex-vivo-dual-perfused-human-single-cotyledon-model
#2
Michal Kovo, Noa Mevorach-Zussman, Nizar Khatib, Yuval Ginsberg, Michael Divon, Zeev Weiner, Jacob Bar, Ron Beloosesky
OBJECTIVES: Multiple mechanisms have been proposed for the neuroprotective effects of magnesium sulfate (MgSO4). We aimed to examine the effects of lipopolysaccharide (LPS) and MgSO4 on the placental expression of nuclear factor κ light chain enhancer of activated B cells (NF-κB), interleukin (IL) 6, adrenocorticotropic hormone (ACTH), and nitric oxide synthase (NOS); all known to participate in the inflammatory cascade. METHODS: Placentas were obtained and selected cotyledons cannulated and dually perfused ex vivo...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29102930/re-evaluation-of-culture-condition-of-pc12-and-sh-sy5y-cells-based-on-growth-rate-and-amino-acid-consumption
#3
Hiroshi Sakagami, Ryuichiro Suzuki, Yoshiaki Shirataki, Soichi Iwama, Mika Nakagawa, Hayato Suzuki, Kenta Tanaka, Nobuaki Tamura, Hiroshi Takeshima
BACKGROUND/AIM: Most of the previous investigators have used various types of media for the culture of nerve cells. In order to optimize the culture conditions, we compared the growth rate and amino acid consumption by two popular neuron models, rat PC12 and human SH-SY5Y, grown in DMEM or DMEM: Ham's F-12 (1:1): non-essential amino acids, supplemented with 10% fetal bovine serum (referred to DMEM and Mix, respectively). MATERIALS AND METHODS: Cell growth was monitored by the MTT method...
November 2017: In Vivo
https://www.readbyqxmd.com/read/29053683/new-application-of-an-atmospheric-pressure-plasma-jet-as-a-neuro-protective-agent-against-glucose-deprivation-induced-injury-of-sh-sy5y-cells
#4
Xu Yan, Zhaozhong Meng, Jiting Ouyang, Yajun Qiao, Fang Yuan
The atmospheric pressure plasma jet (APPJ) has attracted the attention of many researchers from multiple disciplines in recent years because its emissions include multiple types of reactive nitrogen species (RNS) and reactive oxygen species (ROS). Our previous study has shown the cytoprotective effect of the APPJ against oxidative stress-induced injuries. The aim of the present study is to provide a detailed in vitro treatment protocol regarding the neuroprotective applications of helium APPJs on glucose deprivation-induced injury in SH-SY5Y cells...
October 9, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29018332/the-beneficial-effects-of-melatonin-administration-following-hypoxia-ischemia-in-preterm-fetal-sheep
#5
Tamara Yawno, Mawin Mahen, Jingang Li, Michael C Fahey, Graham Jenkin, Suzanne L Miller
Melatonin (MLT) is an endogenous hormone that controls circadian cycle. MLT has additional important properties that make it appealing as a neuroprotective agent-it is a potent anti-oxidant, with anti-apoptotic and anti-inflammatory properties. MLT is safe for administration during pregnancy or to the newborn after birth, and can reduce white matter brain injury under conditions of chronic fetal hypoxia. Accordingly, in the current study, we examined whether an intermediate dose of MLT could restore white matter brain development when administered after an acute hypoxic ischemic (HI) insult in preterm fetal sheep...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29016670/a-novel-function-of-n-linked-glycoproteins-alpha-2-hs-glycoprotein-and-hemopexin-implications-for-small-molecule-compound-mediated-neuroprotection
#6
Takuya Kanno, Kaori Yasutake, Kazunori Tanaka, Shinji Hadano, Joh-E Ikeda
Therapeutic agents to the central nervous system (CNS) need to be efficiently delivered to the target site of action at appropriate therapeutic levels. However, a limited number of effective drugs for the treatment of neurological diseases has been developed thus far. Further, the pharmacological mechanisms by which such therapeutic agents can protect neurons from cell death have not been fully understood. We have previously reported the novel small-molecule compound, 2-[mesityl(methyl)amino]-N-[4-(pyridin-2-yl)-1H-imidazol-2-yl] acetamide trihydrochloride (WN1316), as a unique neuroprotectant against oxidative injury and a highly promising remedy for the treatment of amyotrophic lateral sclerosis (ALS)...
2017: PloS One
https://www.readbyqxmd.com/read/28984591/curcumin-inhibits-tau-aggregation-and-disintegrates-preformed-tau-filaments-in-vitro
#7
Jitendra Subhash Rane, Prasenjit Bhaumik, Dulal Panda
The pathological aggregation of tau is a common feature of most of the neuronal disorders including frontotemporal dementia, Parkinson's disease, and Alzheimer's disease. The inhibition of tau aggregation is considered to be one of the important strategies for treating these neurodegenerative diseases. Curcumin, a natural polyphenolic molecule, has been reported to have neuroprotective ability. In this work, curcumin was found to bind to adult tau and fetal tau with a dissociation constant of 3.3±0.4 and 8±1 μM, respectively...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28981488/from-cord-to-caudate-characterizing-umbilical-cord-blood-stem-cells-and-their-paracrine-interactions-with-the-injured-brain
#8
REVIEW
Priya F Maillacheruvu, Lauren M Engel, Isaiah T Crum, Devendra K Agrawal, Eric S Peeples
Stem cells are proving to be a promising therapy for a wide range of pediatric disorders, from neonatal hypoxic-ischemic encephalopathy to pediatric leukemia. Due to their low immunogenicity and ease of availability, umbilical cord blood (UCB) progenitor cells are increasingly replacing fetal and adult-derived cells in therapeutic settings. Multiple environmental and demographic factors affect the number and type of stem cells extracted from UCB, and these differences have been associated with disparities in outcomes after transplantation...
October 5, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28976987/assessing-the-neuroprotective-benefits-for-babies-of-antenatal-magnesium-sulphate-an-individual-participant-data-meta-analysis
#9
Caroline A Crowther, Philippa F Middleton, Merryn Voysey, Lisa Askie, Lelia Duley, Peter G Pryde, Stéphane Marret, Lex W Doyle
BACKGROUND: Babies born preterm are at an increased risk of dying in the first weeks of life, and those who survive have a higher rate of cerebral palsy (CP) compared with babies born at term. The aim of this individual participant data (IPD) meta-analysis (MA) was to assess the effects of antenatal magnesium sulphate, compared with no magnesium treatment, given to women at risk of preterm birth on important maternal and fetal outcomes, including survival free of CP, and whether effects differed by participant or treatment characteristics such as the reason the woman was at risk of preterm birth, why treatment was given, the gestational age at which magnesium sulphate treatment was received, or the dose and timing of the administration of magnesium sulphate...
October 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28966649/dexmedetomidine-mitigates-isoflurane-induced-neurodegeneration-in-fetal-rats-during-the-second-trimester-of-pregnancy
#10
Zhi-Yuan Su, Qing Ye, Xian-Bao Liu, Yu-Zhong Chen, Hong Zhan, Shi-Yuan Xu
Dexmedetomidine has significant neuroprotective effects. However, whether its protective effects can reduce neurotoxicity caused by isoflurane in fetal brain during the second trimester of pregnancy remains unclear. In this study, timed-pregnancy rats at gestational day 14 spontaneously inhaled 1.5% isoflurane for 4 hours, and were intraperitoneally injected with dexmedetomidine at dosages of 5, 10, 20, and 20 μg/kg 15 minutes before inhalation and after inhalation for 2 hours. Our results demonstrate that 4 hours after inhaling isoflurane, 20 μg/kg dexmedetomidine visibly mitigated isoflurane-induced neuronal apoptosis, reversed downregulation of brain-derived neurotrophic factor expression, and lessened decreased spatial learning and memory ability in adulthood in the fetal rats...
August 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28962577/acute-maternal-oxidant-exposure-causes-susceptibility-of-the-fetal-brain-to-inflammation-and-oxidative-stress
#11
Feroz Akhtar, Christopher A Rouse, Gabriel Catano, Marcus Montalvo, Sarah L Ullevig, Reto Asmis, Kusum Kharbanda, Shivani K Maffi
BACKGROUND: Maternal exposure to environmental stressors poses a risk to fetal development. Oxidative stress (OS), microglia activation, and inflammation are three tightly linked mechanisms that emerge as a causal factor of neurodevelopmental anomalies associated with prenatal ethanol exposure. Antioxidants such as glutathione (GSH) and CuZnSOD are perturbed, and their manipulation provides evidence for neuroprotection. However, the cellular and molecular effects of GSH alteration in utero on fetal microglia activation and inflammation remain elusive...
September 30, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28903747/antenatal-magnesium-sulphate-administration-for-fetal-neuroprotection-a-french-national-survey
#12
Clément Chollat, Lise Le Doussal, Gaëlle de la Villéon, Delphine Provost, Stéphane Marret
BACKGROUND: Magnesium sulphate (MgSO4) is the only treatment approved for fetal neuroprotection. No information on its use is available in the absence of a national registry of neonatal practices. The objective of our study was to evaluate the use of MgSO4 for fetal neuroprotection in French tertiary maternity hospitals (FTMH). METHODS: Online and phone survey of all FTMH between August 2014 and May 2015. A participation was expected from one senior obstetrician, one senior anaesthetist and one senior neonatologist from each FTMH...
September 13, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28878260/%C3%AE-7-nicotinic-acetylcholine-receptor-signaling-modulates-the-inflammatory-phenotype-of-fetal-brain-microglia-first-evidence-of-interference-by-iron-homeostasis
#13
M Cortes, M Cao, H L Liu, C S Moore, L D Durosier, P Burns, G Fecteau, A Desrochers, L B Barreiro, J P Antel, M G Frasch
Neuroinflammation in utero may result in life-long neurological disabilities. Microglia play a pivotal role, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of microglia. We hypothesized that agonism on α7 nicotinic acetylcholine receptor (α7nAChR) in fetal microglia will augment their neuroprotective transcriptome profile, while the antagonistic stimulation of α7nAChR will achieve the opposite. Using an in vivo - in vitro model of developmental programming of neuroinflammation induced by lipopolysaccharide (LPS), we validated this hypothesis in primary fetal sheep microglia cultures re-exposed to LPS in presence of a selective α7nAChR agonist or antagonist...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28873067/association-of-histological-chorioamnionitis-and-magnesium-sulfate-treatment-in-singleton-and-dichorionic-twin-pregnancies-with-preterm-premature-rupture-of-membranes-preliminary-observations
#14
James M O'Brien, Jacobo L Santolaya, Kristy Palomares, David Blitzer, Joaquin Santolaya-Forgas
OBJECTIVE: To evaluate the possible association between antenatal magnesium sulfate treatment with histological chorioamnionitis in patients with singleton or dichorionic twins that had preterm premature rupture of the membranes. METHODS: This was an observational study performed in patients admitted to the hospital with rupture of membranes before 34 weeks' gestation. The primary outcome was histological chorioamnionitis and the primary predictor was antenatal magnesium sulfate treatment...
September 5, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28856805/reactive-astrocyte-cox2-pge2-production-inhibits-oligodendrocyte-maturation-in-neonatal-white-matter-injury
#15
Lawrence R Shiow, Geraldine Favrais, Lucas Schirmer, Anne-Laure Schang, Sara Cipriani, Christian Andres, Jaclyn N Wright, Hiroko Nobuta, Bobbi Fleiss, Pierre Gressens, David H Rowitch
Inflammation is a major risk factor for neonatal white matter injury (NWMI), which is associated with later development of cerebral palsy. Although recent studies have demonstrated maturation arrest of oligodendrocyte progenitor cells (OPCs) in NWMI, the identity of inflammatory mediators with direct effects on OPCs has been unclear. Here, we investigated downstream effects of pro-inflammatory IL-1β to induce cyclooxygenase-2 (COX2) and prostaglandin E2 (PGE2) production in white matter. First, we assessed COX2 expression in human fetal brain and term neonatal brain affected by hypoxic-ischemic encephalopathy (HIE)...
August 30, 2017: Glia
https://www.readbyqxmd.com/read/28817212/fingolimod-against-endotoxin-induced-fetal-brain-injury-in-a-rat-model
#16
And Yavuz, Mekin Sezik, Ozlem Ozmen, Halil Asci
AIM: Fingolimod is a sphingosine-1-phosphate receptor modulator used for multiple sclerosis treatment and acts on cellular processes such as apoptosis, endothelial permeability, and inflammation. We hypothesized that fingolimod has a positive effect on alleviating preterm fetal brain injury. METHODS: Sixteen pregnant rats were divided into four groups of four rats each. On gestational day 17, i.p. endotoxin was injected to induce fetal brain injury, followed by i...
August 17, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28805973/experimental-and-clinical-evidence-of-differential-effects-of-magnesium-sulfate-on-neuroprotection-and-angiogenesis-in-the-fetal-brain
#17
Matthieu Lecuyer, Marina Rubio, Clément Chollat, Maryline Lecointre, Sylvie Jégou, Philippe Leroux, Carine Cleren, Isabelle Leroux-Nicollet, Loic Marpeau, Denis Vivien, Stéphane Marret, Bruno J Gonzalez
Clinical studies showed beneficial effects of magnesium sulfate regarding the risk of cerebral palsy. However, regimen protocols fluctuate worldwide and risks of adverse effects impacting the vascular system have been reported for human neonates, keeping open the question of the optimal dosing. Using clinically relevant concentrations and doses of magnesium sulfate, experiments consisted of characterizing, respectively, ex vivo and in vivo, the effects of magnesium sulfate on the nervous and vascular systems of mouse neonates by targeting neuroprotection, angiogenesis, and hemodynamic factors and in measuring, in human fetuses, the impact of a 4-g neuroprotective loading dose of magnesium sulfate on brain hemodynamic parameters...
August 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28804448/erythropoietin-protects-against-lipopolysaccharide-induced-microgliosis-and-abnormal-granule-cell-development-in-the-ovine-fetal-cerebellum
#18
Annie R A McDougall, Nadia Hale, Sandra Rees, Richard Harding, Robert De Matteo, Stuart B Hooper, Mary Tolcos
Erythropoietin (EPO) ameliorates inflammation-induced injury in cerebral white matter (WM). However, effects of inflammation on the cerebellum and neuroprotective effects of EPO are unknown. Our aims were to determine: (i) whether lipopolysaccharide (LPS)-induced intrauterine inflammation causes injury to, and/or impairs development of the cerebellum; and (ii) whether recombinant human EPO (rhEPO) mitigates these changes. At 107 ± 1 days gestational age (DGA; ~0.7 of term), fetal sheep received LPS (~0.9 μg/kg; i...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28776755/maternal-administration-of-melatonin-exerts-short-and-long-term-neuroprotective-effects-on-the-offspring-from-lipopolysaccharide-treated-mice
#19
Ana Paula Domínguez Rubio, Fernando Correa, Julieta Aisemberg, Damián Dorfman, María Victoria Bariani, Ruth Estela Rosenstein, María Zorrilla Zubilete, Ana María Franchi
Preterm birth is a major contributor to early and delayed physical and cognitive impairment. Epidemiological and experimental data indicate that maternal infections are a significant and preventable cause of preterm birth. Recently, melatonin has been suggested to exert neuroprotective effects in several models of brain injury. Here, we sought to investigate whether the administration of melatonin is able to prevent lipopolysaccharide (LPS)-induced fetal brain damage in a model of LPS-induced preterm labor...
August 4, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28734732/perinatal-and-neonatal-use-of-sedation-and-analgesia
#20
REVIEW
Christopher McPherson, Terrie Inder
Optimal obstetric and neonatal care requires the provision of adequate analgesia for painful procedures. However, anesthetic and analgesic agents have the potential to adversely impact the developing fetal/neonatal brain. In this setting, clinicians must assess the risks and benefits of pharmacologic anesthesia and analgesia for specific indications in this population. General anesthesia is required for non-obstetric surgery and cesarean section in the absence of neuraxial anesthesia for the health of the mother and fetus...
October 2017: Seminars in Fetal & Neonatal Medicine
keyword
keyword
83082
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"