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Colistin in childrens

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https://www.readbyqxmd.com/read/29034106/epidemiology-and-antibiotic-resistance-phenotypes-of-diarrheagenic-escherichia-coli-responsible-for-infantile-gastroenteritis-in-ouagadougou-burkina-faso
#1
Ali Konaté, René Dembélé, Nathalie K Guessennd, Fernique Konan Kouadio, Innocent Kouamé Kouadio, Mohamed Baguy Ouattara, Wendpoulomdé A D Kaboré, Assèta Kagambèga, Haoua Cissé, Hadiza Bawa Ibrahim, Touwendsida Serge Bagré, Alfred S Traoré, Nicolas Barro
The emergence and persistence of multidrug-resistant (MDR) diarrheagenic Escherichia coli (DEC) causing acute diarrhea is a major public health challenge in developing countries. The aim of this study was to evaluate the resistance phenotypes of DEC isolated from stool samples collected from children less than 5 years of age with acute diarrhea living in Ouagadougou/Burkina Faso. From August 2013 to October 2015, this study was carried out on 31 DEC strains of our study conducted in "Centre Médical avec Antenne Chirurgicale (CMA)" Paul VI and CMA of Schiphra...
September 2017: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/29020309/colistin-auc-in-children-treated-with-intravenous-loading-dose-and-maintenance-therapy
#2
Alessio Mesini, Anna Loy, Marco Gattorno, Andrea Moscatelli, Roberto Bandettini, Maura Faraci, Giuliana Cangemi, Elio Castagnola
No abstract text is available yet for this article.
August 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28729206/antimicrobial-resistance-patterns-of-gram-negative-bacteria-isolated-from-bloodstream-infections-in-an-iranian-referral-paediatric-hospital-a-5-5-year-study
#3
Shima Mahmoudi, Masoumeh Mahzari, Maryam Banar, Babak Pourakbari, Mohammad Taghi Haghi Ashtiani, Mohsen Mohammadi, Sepideh Keshavarz Valian, Setareh Mamishi
OBJECTIVES: Bloodstream infections (BSIs) are a major cause of paediatric morbidity and mortality worldwide. This study describes the epidemiology and antimicrobial resistance of Gram-negative bacteria (GNB) from BSIs in children admitted to an Iranian paediatric hospital. METHODS: Clinical and microbiological data of patients with positive blood cultures were collected from March 2011 to September 2016. Standard laboratory methods were used for blood culture and bacterial identification...
July 17, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28716109/clinical-characteristics-and-outcomes-of-pseudomonas-aeruginosa-bacteremia-in-febrile-neutropenic-children-and-adolescents-with-the-impact-of-antibiotic-resistance-a-retrospective-study
#4
Hyo Sup Kim, Bo Kyoung Park, Seong Koo Kim, Seung Beom Han, Jae Wook Lee, Dong-Gun Lee, Nack-Gyun Chung, Bin Cho, Dae Chul Jeong, Jin Han Kang
BACKGROUND: Although the proportion of Pseudomonas aeruginosa infections has reduced after the introduction of antibiotics with anti-pseudomonal effects, P. aeruginosa bacteremia still causes high mortality in immunocompromised patients. This study determined the clinical characteristics and outcomes of P. aeruginosa bacteremia and the antibiotic susceptibilities of strains isolated from febrile neutropenic patients. METHODS: Thirty-one febrile neutropenic children and adolescents with underlying hematologic/oncologic disorders diagnosed with P...
July 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28668691/colistin-resistance-gene-mcr-1-in-gut-flora-of-children
#5
Yan-Yan Hu, Yue-Ling Wang, Qiao-Ling Sun, Zi-Xian Huang, Han-Yu Wang, Rong Zhang, Gong-Xiang Chen
The aim of this study was to determine the prevalence and transmission mechanism(s) of mcr-1 in the gut flora of children. Faecal samples (n = 173) were obtained from non-diarrhoea patients at the Children's Hospital of Zhejiang University (Hangzhou, China). PCR-based analysis indicated that 17 isolates from 9.8% of the samples were positive for mcr-1, comprising 16 Escherichia coli and 1 Citrobacter freundii. Nine mcr-1-bearing isolates co-expressed extended-spectrum β-lactamase (ESBL) genes, but plasmid-mediated quinolone resistance (PMQR) genes were not detected...
October 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28650936/colistin-use-in-neonates-and-children-with-infections-due-to-carbapenem-resistant-bacteria
#6
REVIEW
Charalampos Antachopoulos, Elias Iosifidis
Current evidence on the use of colistin in pediatric patients for infections caused by carbapenem-resistant bacteria is based on retrospective case series. The coadministration of colistin with other antimicrobial agents was associated with a relatively low rate of nephrotoxicity and a favorable outcome in >70% of these patients. Further study of colistin pharmacokinetics in children and neonates will likely lead to optimization of dosage recommendations.
September 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28594635/epidemiology-of-carbapenem-resistant-klebsiella-pneumoniae-bloodstream-infections-in-a-chinese-children-s-hospital-predominance-of-new-delhi-metallo-%C3%AE-lactamase-1
#7
Fang Dong, Ye Zhang, Kaihu Yao, Jie Lu, Lingyun Guo, Shuang Lyu, Ying Yang, Yan Wang, Hongyan Zheng, Wenqi Song, Gang Liu
The spread of carbapenem-resistant Klebsiella pneumoniae (CRKp) has become a significant problem worldwide; however, relevant data in children are limited. We performed a retrospective study to better understand the epidemiology of CRKp bloodstream infections at Beijing Children's Hospital. A total of 164 K. pneumoniae strains were collected from blood cultures between January 2011 and September 2014, of which 52 (31.7%) were CRKp strains. All 52 CRKp strains were multidrug resistant; 46 (88.5%) and 49 (94...
June 8, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28440853/antibiotic-strategies-for-eradicating-pseudomonas-aeruginosa-in-people-with-cystic-fibrosis
#8
REVIEW
Simon C Langton Hewer, Alan R Smyth
BACKGROUND: Respiratory tract infection with Pseudomonas aeruginosa occurs in most people with cystic fibrosis. Once chronic infection is established, Pseudomonas aeruginosa is virtually impossible to eradicate and is associated with increased mortality and morbidity. Early infection may be easier to eradicate.This is an update of a Cochrane review first published in 2003, and previously updated in 2006, 2009 and 2014. OBJECTIVES: To determine whether antibiotic treatment of early Pseudomonas aeruginosa infection in children and adults with cystic fibrosis eradicates the organism, delays the onset of chronic infection, and results in clinical improvement...
April 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28383517/antibiotic-resistance-in-an-indian-rural-community-a-one-health-observational-study-on-commensal-coliform-from-humans-animals-and-water
#9
Manju Raj Purohit, Salesh Chandran, Harshada Shah, Vishal Diwan, Ashok J Tamhankar, Cecilia Stålsby Lundborg
Antibiotic-resistant bacteria are an escalating grim menace to global public health. Our aim is to phenotype and genotype antibiotic-resistant commensal Escherichia coli (E. coli) from humans, animals, and water from the same community with a 'one-health' approach. The samples were collected from a village belonging to demographic surveillance site of Ruxmaniben Deepchand (R.D.) Gardi Medical College Ujjain, Central India. Commensal coliforms from stool samples from children aged 1-3 years and their environment (animals, drinking water from children's households, common source- and waste-water) were studied for antibiotic susceptibility and plasmid-encoded resistance genes...
April 6, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28248714/nebulization-of-antiinfective-agents-in-invasively-mechanically-ventilated-adults-a-systematic-review-and-meta-analysis
#10
REVIEW
Candela Solé-Lleonart, Jean-Jacques Rouby, Stijn Blot, Garyfallia Poulakou, Jean Chastre, Lucy B Palmer, Matteo Bassetti, Charles-Edouard Luyt, Jose M Pereira, Jordi Riera, Tim Felton, Jayesh Dhanani, Tobias Welte, Jose M Garcia-Alamino, Jason A Roberts, Jordi Rello
BACKGROUND: Nebulization of antiinfective agents is a common but unstandardized practice in critically ill patients. METHODS: A systematic review of 1,435 studies was performed in adults receiving invasive mechanical ventilation. Two different administration strategies (adjunctive and substitute) were considered clinically relevant. Inclusion was restricted to studies using jet, ultrasonic, and vibrating-mesh nebulizers. Studies involving children, colonized-but-not-infected adults, and cystic fibrosis patients were excluded...
May 2017: Anesthesiology
https://www.readbyqxmd.com/read/28135233/use-of-colistin-in-a-neonatal-intensive-care-unit-a-cohort-study-of-65-patients
#11
Eren Çağan, Evrim Kıray Baş, Hüseyin Selim Asker
BACKGROUND The emergence of infections related to multidrug-resistant Gram-negative bacilli (MDR-GNB) reintroduced the use of colistin, an antibiotic that was previously abandoned due to adverse effects. However, because of its limited use in neonatal intensive care units, there is very little data about the effectiveness and safety of colistin in children and newborns. In this study, which will be the largest case study in the literature, we aimed to evaluate the effectiveness and safety of colistin in full-term and preterm newborns...
January 30, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28088916/an-increasing-threat-in-an-iranian-referral-children-s-hospital-multidrug-resistant-acinetobacter-baumannii
#12
Setareh Mamishi, Reza Habibi, Babak Pourakbari, Shima Mahmoudi, Mohammad Taghi Haghi Ashtiani, Reihaneh Hosseinpour Sadeghi, Mahmoud Khodabandeh
INTRODUCTION: Acinetobacter baumannii has emerged as an important nosocomial pathogen in the past decades. Due to the prevalence of A. baumannii across the world, suitable typing methods to investigate the epidemiological distribution of the organism have been developed. The aim of this study was to investigate the epidemiological and molecular diversity of A. baumannii strains isolated from nosocomial infections of hospitalized children in Children Medical Center Hospital (CMC), an Iranian referral hospital, in Tehran, Iran...
January 13, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/27994915/intravenous-colistin-use-for-multidrug-resistant-gram-negative-infections-in-pediatric-patients
#13
Ayşe Karaaslan, Eren Çağan, Eda Kepenekli Kadayifci, Serkan Atıcı, Gülşen Akkoç, Nurhayat Yakut, Sevliya Öcal Demir, Ahmet Soysal, Mustafa Bakır
BACKGROUND: The emergence of infections due to multidrug-resistant Gram-negative bacilli (MDR-GNB) has led to the resurrection of colistin use. The data on colistin use and drug-related adverse effects in children are scarce. AIMS: In this study, we aimed to evaluate the clinical efficacy and safety of colistin use in critically ill pediatric patients. STUDY DESIGN: This study has a retrospective study design. METHODS: Sixty-one critically ill children were identified through the department's patient files archive during the period from January 2011 to November 2014...
November 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27854381/interventions-for-children-with-ear-discharge-occurring-at-least-two-weeks-following-grommet-ventilation-tube-insertion
#14
REVIEW
Roderick P Venekamp, Faisal Javed, Thijs Ma van Dongen, Angus Waddell, Anne Gm Schilder
BACKGROUND: Ear discharge (otorrhoea) is common in children with grommets (ventilation/tympanostomy tubes); the proportion of children developing discharge ranges from 25% to 75%. The most common treatment strategies include oral broad-spectrum antibiotics, antibiotic eardrops or those containing a combination of antibiotic(s) and a corticosteroid, and initial observation. Important drivers for one strategy over the other are concerns over the side effects of oral antibiotics and the potential ototoxicity of antibiotic eardrops...
November 17, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27601110/invasive-carbapenem-resistant-enterobacteriaceae-infection-at-a-paediatric-hospital-a-case-series
#15
Oliver Ombeva Malande, Annerie Du Plessis, Diane Rip, Colleen Bamford, Brian Eley
BACKGROUND: There are no paediatric reports of invasive infection caused by carbapenem-resistant Enterobacteriaceae (CRE) from Africa. OBJECTIVES: To document a series of cases of CRE infections at a tertiary children's hospital in Cape Town, South Africa, describing the clinical and microbiological findings in these children. METHODS: A retrospective, descriptive study was completed using data from a series of children with invasive CRE infection between 2010 and 2015, sourced from their clinical notes and microbiology results...
August 18, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27399106/high-prevalence-of-hospital-acquired-infections-caused-by-gram-negative-carbapenem-resistant-strains-in-vietnamese-pediatric-icus-a-multi-centre-point-prevalence-survey
#16
MULTICENTER STUDY
Ngai Kien Le, Wertheim Hf, Phu Dinh Vu, Dung Thi Khanh Khu, Hai Thanh Le, Bich Thi Ngoc Hoang, Vu Thanh Vo, Yen Minh Lam, Dung Tien Viet Vu, Thu Hoai Nguyen, Tung Quang Thai, Lennart E Nilsson, Ulf Rydell, Kinh Van Nguyen, Behzad Nadjm, Louise Clarkson, Håkan Hanberger, Mattias Larsson
There is scarce information regarding hospital-acquired infections (HAIs) among children in resource-constrained settings. This study aims to measure prevalence of HAIs in Vietnamese pediatric hospitals.Monthly point prevalence surveys (PPSs) in 6 pediatric intensive care units (ICUs) in 3 referral hospitals during 1 year.A total of 1363 cases (1143 children) were surveyed, 59.9% male, average age 11 months. Admission sources were: other hospital 49.3%, current hospital 36.5%, and community 15.3%. Reasons for admission were: infectious disease (66%), noninfectious (20...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27180312/beta-lactamases-in-enterobacteriaceae-infections-in-children
#17
REVIEW
Christopher Alan Moxon, Stéphane Paulus
Multi-drug resistance in Gram negative bacteria, particularly in Enterobacteriaceae, is a major clinical and public health challenge. The main mechanism of resistance in Enterobacteriaceae is linked to the production of beta-lactamase hydrolysing enzymes such as extended spectrum beta-lactamases (ESBL), AmpC beta-lactamases and carbapenemases (Carbapenemase Producing Enterobacteriaceae (CPE)). ESBL and CPE resistance genes are located on plasmids, which can be transmitted between Enterobacteriaceae, facilitating their spread in hospitals and communities...
July 5, 2016: Journal of Infection
https://www.readbyqxmd.com/read/27041107/is-colistin-effective-in-the-treatment-of-infections-caused-by-multidrug-resistant-mdr-or-extremely-drug-resistant-xdr-gram-negative-microorganisms-in-children
#18
Yasemin Ozsurekci, Kubra Aykac, Ali Bulent Cengiz, Cihangul Bayhan, Banu Sancak, Eda Karadag Oncel, Ates Kara, Mehmet Ceyhan
The increasing incidence of infections caused by multidrug-resistant (MDR) or extremely drug-resistant (XDR) gram-negative organisms has led to the reemergence of colistin use. Clinical and demographic data were collected on 94 pediatric patients diagnosed with MDR or XDR gram-negative infections and treated with either a colistin-containing regimen (colistin group) or at least one antimicrobial agent other than colistin (noncolistin group). The overall clinical response rates were 65.8% in the colistin group and 70...
June 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27000866/use-of-tigecycline-in-pediatric-patients-with-infections-predominantly-due-to-extensively-drug-resistant-gram-negative-bacteria
#19
Elias Iosifidis, Asimenia Violaki, Evangelia Michalopoulou, Elena Volakli, Elisavet Diamanti, Dimitrios Koliouskas, Charalampos Antachopoulos, Vasiliki Drossou-Agakidou, Maria Sdougka, Emmanuel Roilides
Background.: Emergence of extensively drug-resistant (XDR) bacteria has forced clinicians to use off-label antimicrobial agents such as tigecycline. We present our experience on salvage use of tigecycline for the treatment of infections caused by XDR Gram-negative bacteria in critically ill children and review published cases. Methods.: We conducted a retrospective chart review in pediatric departments of a tertiary level hospital from January 2009 to May 2014. Patients were identified using pharmacy database...
June 1, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/26915861/colistin-an-old-drug-in-a-new-territory-solid-organ-transplantation
#20
D F Florescu, C Mindru, M A Keck, F Qiu, A C Kalil
BACKGROUND: The clinical experience with colistin therapy for multidrug-resistant Gram-negative pathogens in solid organ transplantation is limited. METHODS: Patients transplanted from January 2003 to July 2011 and treated with intravenous or nebulized colistin were included. Descriptive statistics were used to summarize patients' characteristics and Kaplan-Meier curves for survival analysis. RESULTS: Fifteen patients were included: 10 adults (median age, 54...
January 2016: Transplantation Proceedings
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