keyword
MENU ▼
Read by QxMD icon Read
search

target treatment

keyword
https://www.readbyqxmd.com/read/27936456/1%C3%AE-25-dihydroxyvitamin-d-inhibits-de-novo-fatty-acid-synthesis-and-lipid-accumulation-in-metastatic-breast-cancer-cells-through-down-regulation-of-pyruvate-carboxylase
#1
Tomasz Wilmanski, Kimberly Buhman, Shawn S Donkin, John R Burgess, Dorothy Teegarden
Both increased de novo fatty acid synthesis and higher neutral lipid accumulation are a common phenotype observed in aggressive breast cancer cells, making lipid metabolism a promising target for breast cancer prevention. In the present studies, we demonstrate a novel effect of the active metabolite of vitamin D, 1α,25-dihydroxyvitamin D (1,25(OH)₂D) on lipid metabolism in malignant breast epithelial cells. Treatment of MCF10CA1a breast epithelial cells with 1,25(OH)₂D (10 nM) for 5 and 7 days decreased the level of triacylglycerol, the most abundant form of neutral lipids, by 20%(±3...
December 1, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27936410/body-image-and-emotional-distress-in-newly-diagnosed-cancer-patients-the-mediating-role-of-dysfunctional-attitudes-and-rumination
#2
Jianlin Liu, Chao Xu Peh, Rathi Mahendran
Body image concerns (BIC) has been reported to be associated with emotional distress for cancers across various sites. This study sought to examine two cognitive vulnerability mechanisms: dysfunctional attitudes and rumination, and their combined effects on the relationship between BIC and emotional distress in newly diagnosed Asian cancer patients. Participants were 221 newly diagnosed adult cancer patients who were assessed on BIC, rumination, dysfunctional attitudes, and emotional distress. Path analysis was used to examine the hypothesized mediation model...
December 6, 2016: Body Image
https://www.readbyqxmd.com/read/27936379/clinical-and-epidemiological-characteristics-associated-with-unfavorable-tuberculosis-treatment-outcomes-in-tb-hiv-co-infected-patients-in-brazil-a-hierarchical-polytomous-analysis
#3
Thiago Nascimento do Prado, Jayant V Rajan, Angélica Espinosa Miranda, Elias Dos Santos Dias, Lorrayne Beliqui Cosme, Lia Gonçalves Possuelo, Mauro N Sanchez, Jonathan E Golub, Lee W Riley, Ethel Leonor Maciel
BACKGROUND: TB patients co-infected with HIV have worse treatment outcomes than non-coinfected patients. How clinical characteristics of TB and socioeconomic characteristics influence these outcomes is poorly understood. Here, we use polytomous regression analysis to identify clinical and epidemiological characteristics associated with unfavorable treatment outcomes among TB-HIV co-infected patients in Brazil. METHODS: TB-HIV cases reported in the Brazilian information system (SINAN) between January 1, 2001 and December 31, 2011 were identified and categorized by TB treatment outcome (cure, default, death, and development of MDR TB)...
December 6, 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27936376/peer-network-counseling-as-brief-treatment-for-urban-adolescent-heavy-cannabis-users
#4
Michael J Mason, Roy Sabo, Nikola M Zaharakis
OBJECTIVE: A small body of evidence supports targeting adolescents who are heavy users of cannabis with brief interventions, yet more research is needed to confirm the effectiveness of these studies. We conducted a secondary analysis of our Peer Network Counseling (PNC) study (Mason et al., 2015), focusing on 46 adolescents of the sample of 119 who reported heavy cannabis use at baseline. METHOD: Urban adolescents (91% African American) presenting for primary health care were randomized to intervention or control conditions and followed for 6 months...
January 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/27936333/alcohol-use-disorder-in-older-adults-challenges-in-assessment-and-treatment
#5
Mary C DiBartolo, Judith M Jarosinski
Alcohol use disorder (AUD) is a common, under-recognized, and under-treated health concern in older adults. Its prevalence is expected to reach unprecedented levels as the U.S. population ages; consequently, it is poised to place a significant burden on the healthcare system. Given the growing body of evidence regarding the patterns of use in this age group and the serious consequences of its misuse, it is critical that nurses and other healthcare providers assess for AUD in order to identify older adults in need of treatment...
December 9, 2016: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/27936277/algorithm-driven-dosage-decisions-ad3-optimizing-treatment-for-children-with-language-impairment
#6
Laura M Justice, Jessica Logan, Hui Jiang, Mary Beth Schmitt
Background: This study was designed to provide recommended amounts of treatment to achieve the optimal amount of language gain for children with language impairment. Method: The authors retrospectively analyzed treatment outcomes for 233 children for delivered dose, intensity, and cumulative intensity of therapy. The steps of the analytical process they applied to arrive at algorithms for recommended amounts of treatment were (1) multilevel modeling to predict children's language gains from the 3 intensity parameters and (2) extraction of regression weights to create a recommended amount of treatment...
December 9, 2016: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/27936237/the-immunomodulatory-small-molecule-imiquimod-induces-apoptosis-in-devil-facial-tumour-cell-lines
#7
Amanda L Patchett, Jocelyn M Darby, Cesar Tovar, A Bruce Lyons, Gregory M Woods
The survival of the Tasmanian devil (Sarcophilus harrisii) is threatened by devil facial tumour disease (DFTD). This transmissible cancer is usually fatal, and no successful treatments have been developed. In human studies, the small immunomodulatory molecule imiquimod is a successful immunotherapy, activating anti-tumour immunity via stimulation of toll-like receptor-7 (TLR7) signaling pathways. In addition, imiquimod is a potent inducer of apoptosis in human tumour cell lines via TLR7 independent mechanisms...
2016: PloS One
https://www.readbyqxmd.com/read/27936110/women-s-perceived-reasons-for-their-excessive-postpartum-weight-retention-a-qualitative-interview-study
#8
Anne Christenson, Eva Johansson, Signy Reynisdottir, Jarl Torgerson, Erik Hemmingsson
INTRODUCTION: Obesity in Sweden has doubled to 14% over the last 20 years. New strategies for treatment and prevention are needed. Excessive gestational weight gain has been found to contribute substantially to obesity, and there is a consistent association between postpartum weight retention and obesity later in life. We aimed to explore what factors women perceive as reasons for having substantial postpartum weight retention, to identify areas for new and improved interventions. METHODS: Qualitative interview study (semi-structured) using an emergent design...
2016: PloS One
https://www.readbyqxmd.com/read/27936071/foot-conditions-among-homeless-persons-a-systematic-review
#9
Matthew J To, Thomas D Brothers, Colin Van Zoost
INTRODUCTION: Foot problems are common among homeless persons, but are often overlooked. The objectives of this systematic review are to summarize what is known about foot conditions and associated interventions among homeless persons. METHODS: A literature search was conducted on MEDLINE (1966-2016), EMBASE (1947-2016), and CINAHL (1982-2016) and complemented by manual searches of reference lists. Articles that described foot conditions in homeless persons or associated interventions were included...
2016: PloS One
https://www.readbyqxmd.com/read/27936053/predicting-30-day-readmissions-in-an-asian-population-building-a-predictive-model-by-incorporating-markers-of-hospitalization-severity
#10
Lian Leng Low, Nan Liu, Sijia Wang, Julian Thumboo, Marcus Eng Hock Ong, Kheng Hock Lee
BACKGROUND: To reduce readmissions, it may be cost-effective to consider risk stratification, with targeting intervention programs to patients at high risk of readmissions. In this study, we aimed to derive and validate a prediction model including several novel markers of hospitalization severity, and compare the model with the LACE index (Length of stay, Acuity of admission, Charlson comorbidity index, Emergency department visits in past 6 months), an established risk stratification tool...
2016: PloS One
https://www.readbyqxmd.com/read/27936029/growth-hormone-mediates-its-protective-effect-in-hepatic-apoptosis-through-hnf6
#11
Kewei Wang, Minhua Wang, Maureen Gannon, AiXuan Holterman
BACKGROUND AND AIMS: Growth hormone (GH) not only supports hepatic metabolism but also protects against hepatocyte cell death. Hnf6 (or Oc1) belonging to the Onecut family of hepatocyte transcription factors known to regulate differentiated hepatic function, is a GH-responsive gene. We evaluate if GH mediates Hnf6 activity to attenuate hepatic apoptotic injury. METHODS: We used an animal model of hepatic apoptosis by bile duct ligation (BDL) with Hnf6 -/- (KO) mice in which hepatic Hnf6 was conditionally inactivated...
2016: PloS One
https://www.readbyqxmd.com/read/27935997/endoplasmic-reticulum-targeted-subunit-toxins-provide-a-new-approach-to-rescue-misfolded-mutant-proteins-and-revert-cell-models-of-genetic-diseases
#12
Humaira Adnan, Zhenbo Zhang, Hyun-Joo Park, Chetankumar Tailor, Clare Che, Mustafa Kamani, George Spitalny, Beth Binnington, Clifford Lingwood
Many germ line diseases stem from a relatively minor disturbance in mutant protein endoplasmic reticulum (ER) 3D assembly. Chaperones are recruited which, on failure to correct folding, sort the mutant for retrotranslocation and cytosolic proteasomal degradation (ER-associated degradation-ERAD), to initiate/exacerbate deficiency-disease symptoms. Several bacterial (and plant) subunit toxins, retrograde transport to the ER after initial cell surface receptor binding/internalization. The A subunit has evolved to mimic a misfolded protein and hijack the ERAD membrane translocon (dislocon), to effect cytosolic access and cytopathology...
2016: PloS One
https://www.readbyqxmd.com/read/27935995/into-the-bowels-of-depression-unravelling-medical-symptoms-associated-with-depression-by-applying-machine-learning-techniques-to-a-community-based-population-sample
#13
Joanna F Dipnall, Julie A Pasco, Michael Berk, Lana J Williams, Seetal Dodd, Felice N Jacka, Denny Meyer
BACKGROUND: Depression is commonly comorbid with many other somatic diseases and symptoms. Identification of individuals in clusters with comorbid symptoms may reveal new pathophysiological mechanisms and treatment targets. The aim of this research was to combine machine-learning (ML) algorithms with traditional regression techniques by utilising self-reported medical symptoms to identify and describe clusters of individuals with increased rates of depression from a large cross-sectional community based population epidemiological study...
2016: PloS One
https://www.readbyqxmd.com/read/27935974/epigallocatechin-3-gallate-upregulates-mir-221-to-inhibit-osteopontin-dependent-hepatic-fibrosis
#14
M L Arffa, M A Zapf, A N Kothari, V Chang, G N Gupta, X Ding, M M Al-Gayyar, W Syn, N M Elsherbiny, P C Kuo, Z Mi
Osteopontin (OPN) promotes hepatic fibrosis, and developing therapies targeting OPN expression in settings of hepatic injury holds promise. The polyphenol epigallocatechin-3-gallate (EGCG), found in high concentrations in green tea, downregulates OPN expression through OPN mRNA degradation, but the mechanism is unknown. Previous work has shown that microRNAs can decrease OPN mRNA levels, and other studies have shown that EGCG modulates the expression of multiple microRNAs. In our study, we first demonstrated that OPN induces hepatic stellate cells to transform into an activated state...
2016: PloS One
https://www.readbyqxmd.com/read/27935866/hic1-hypermethylated-in-cancer-1-sumoylation-is-dispensable-for-dna-repair-but-is-essential-for-the-apoptotic-dna-damage-response-ddr-to-irreparable-dna-double-strand-breaks-dsbs
#15
Sonia Paget, Marion Dubuissez, Vanessa Dehennaut, Joe Nassour, Brennan T Harmon, Nathalie Spruyt, Ingrid Loison, Corinne Abbadie, Brian R Rood, Dominique Leprince
The tumor suppressor gene HIC1 (Hypermethylated In Cancer 1) encodes a transcriptional repressor mediating the p53-dependent apoptotic response to irreparable DNA double-strand breaks (DSBs) through direct transcriptional repression of SIRT1. HIC1 is also essential for DSB repair as silencing of endogenous HIC1 in BJ-hTERT fibroblasts significantly delays DNA repair in functional Comet assays. HIC1 SUMOylation favours its interaction with MTA1, a component of NuRD complexes. In contrast with irreparable DSBs induced by 16-hours of etoposide treatment, we show that repairable DSBs induced by 1 h etoposide treatment do not increase HIC1 SUMOylation or its interaction with MTA1...
December 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27935862/targeting-of-interleukin-il-17a-inhibits-pdl1-expression-in-tumor-cells-and-induces-anticancer-immunity-in-an-estrogen-receptor-negative-murine-model-of-breast-cancer
#16
Yun-Feng Ma, Chen Chen, Dongqing Li, Min Liu, Zhuang-Wei Lv, Yanhong Ji, Jiru Xu
The expression of IL-17A and programmed death ligand 1 (PDL1) is increased in estrogen receptor-negative breast cancer. IL-17A promotes tumor cell survival and invasiveness and inhibits the antitumor immune response. The PDL1-PD1 (programmed death protein 1) signaling pathway promotes escape from immune surveillance in tumor cells. The pro-tumor properties of IL-17A and PDL1 in various cancers have been previously examined; however, the relationship and roles of IL-17A and PDL1 in ER-negative breast cancer have not been evaluated...
December 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27935837/patient-specific-bacteroides-genome-variants-in-pouchitis
#17
Joseph H Vineis, Daina L Ringus, Hilary G Morrison, Tom O Delmont, Sushila Dalal, Laura H Raffals, Dionysios A Antonopoulos, David T Rubin, A Murat Eren, Eugene B Chang, Mitchell L Sogin
: A 2-year longitudinal microbiome study of 22 patients who underwent colectomy with an ileal pouch anal anastomosis detected significant increases in distinct populations of Bacteroides during 9 of 11 patient visits that coincided with inflammation (pouchitis). Oligotyping and metagenomic short-read annotation identified Bacteroides populations that occurred in early samples, bloomed during inflammation, and reappeared after antibiotic treatment. Targeted cultivation of Bacteroides isolates from the same individual at multiple time points and from several patients detected subtle genomic changes, including the identification of rapidly evolving genomic elements that differentiate isogenic strains of Bacteroides fragilis from the mucosa versus lumen...
November 15, 2016: MBio
https://www.readbyqxmd.com/read/27935823/renal-disease-pathophysiology-and-treatment-contributions-from-the-rat
#18
REVIEW
Linda J Mullins, Bryan R Conway, Robert I Menzies, Laura Denby, John J Mullins
The rat has classically been the species of choice for pharmacological studies and disease modeling, providing a source of high-quality physiological data on cardiovascular and renal pathophysiology over many decades. Recent developments in genome engineering now allow us to capitalize on the wealth of knowledge acquired over the last century. Here, we review rat models of hypertension, diabetic nephropathy, and acute and chronic kidney disease. These models have made important contributions to our understanding of renal diseases and have revealed key genes, such as Ace and P2rx7, involved in renal pathogenic processes...
December 1, 2016: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/27935809/assessing-and-measuring-cognitive-function-in-major-depressive-disorder
#19
Renee-Marie Ragguett, Danielle S Cha, Ron Kakar, Joshua D Rosenblat, Yena Lee, Roger S McIntyre
Cognitive dysfunction is a major component of major depressive disorder (MDD). No 'gold-standard' tool exists for the assessment of cognitive dysfunction for adults with MDD. The use of measurement-based care to improve treatment outcomes invites the need for a systematic screening, evaluation and measurement tool. The aim herein was to provide a succinct summary of literature documenting clinical implication of cognitive dysfunction in MDD, and a review of available screening, diagnostic and measurement tools for cognitive dysfunction in MDD is provided...
November 2016: Evidence-based Mental Health
https://www.readbyqxmd.com/read/27935805/e2f1-mediated-human-pomc-expression-in-ectopic-cushing-s-syndrome
#20
Takako Araki, Ning-Ai Liu, Yukiko Tone, Daniel Cuevas-Ramos, Roy Heltsley, Masahide Tone, Shlomo Melmed
Cushing's syndrome is caused by excessive adrenocorticotropic hormone (ACTH) secretion derived from pituitary corticotroph tumors (Cushing disease) or from non-pituitary tumors (ectopic Cushing's syndrome). Hypercortisolemic features of ectopic Cushing's syndrome are severe, and no definitive treatment for paraneoplastic ACTH excess is available. We aimed to identify subcellular therapeutic targets by elucidating transcriptional regulation of the human ACTH precursor POMC (proopiomelanocortin) and ACTH production in non-pituitary tumor cells and in cell lines derived from patients with ectopic Cushing's syndrome...
November 2016: Endocrine-related Cancer
keyword
keyword
83078
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"