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Cerebral palsy premature

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https://www.readbyqxmd.com/read/28251422/immigrant-generational-status-and-developmental-problems-among-prematurely-born-children
#1
Phylicia T Bediako, Rhonda BeLue, Marianne M Hillemeier
Immigrants in the U.S. often have comparatively favorable health outcomes despite relative socioeconomic disadvantage- a phenomenon termed the Immigrant Paradox. This study examined the relationship between family immigrant status and developmental problems among children born preterm. The 2011-2012 National Survey of Children's Health data collected through a telephone based survey based on parental report of prematurity and other comorbidities were analyzed using multivariate logistic regression analysis to examine seven developmental outcomes...
March 1, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28241924/primary-human-cytomegalovirus-hcmv-infection-in-pregnancy
#2
Horst Buxmann, Klaus Hamprecht, Matthias Meyer-Wittkopf, Klaus Friese
BACKGROUND: In 0.5-4% of pregnancies, the prospective mother sustains a primary infection with human cytomegalovirus (HCMV). An HCMV infection of the fetus in the first or second trimester can cause complex post-encephalitic impairment of the infant brain, leading to motor and mental retardation, cerebral palsy, epilepsy, retinal defects, and progressive hearing loss. METHODS: This review is based on pertinent publications from January 2000 to October 2016 that were retrieved by a selective search in PubMed employing the terms "cytomegalovirus and pregnancy" and "congenital cytomegalovirus...
January 27, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28211317/primary-human-cytomegalovirus-hcmv-infection-in-pregnancy
#3
Horst Buxmann, Klaus Hamprecht, Matthias Meyer-Wittkopf, Klaus Friese
BACKGROUND: In 0.5-4% of pregnancies, the prospective mother sustains a primary infection with human cytomegalovirus (HCMV). An HCMV infection of the fetus in the first or second trimester can cause complex post-encephalitic impairment of the infant brain, leading to motor and mental retardation, cerebral palsy, epilepsy, retinal defects, and progressive hearing loss. METHODS: This review is based on pertinent publications from January 2000 to October 2016 that were retrieved by a selective search in PubMed employing the terms "cytomegalovirus and pregnancy" and "congenital cytomegalovirus...
January 27, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28166926/-neuroprotection-for-preterm-infants-with-antenatal-magnesium-sulphate
#4
S Marret, P-Y Ancel
OBJECTIVE: To evaluate in preterm born children the neuroprotective benefits and the risks, at short- and long-term outcome, of the antenatal administration of magnesium sulphate (MgSO4) in women at imminent risk of preterm delivery. MATERIAL AND METHODS: Computer databases Medline, the Cochrane Library and the recommendations of various international scientific societies. RESULTS: Given the demonstrated benefit of antenatal MgSO4 intravenous administration on the reduction of cerebral palsy rates and the improvement of motor development in children born preterm, it is recommended for all women whose imminent delivery is expected or programmed before 32 weeks of gestation (WG) (grade A)...
December 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/28130919/the-development-of-extremely-premature-infants
#5
Wolfgang Voss, Elke Hobbiebrunken, Uta Ungermann, Michael Wagner, Gabriele Damm
BACKGROUND: Until now, there has been no comprehensive long-term study in Germany on the development of extremely premature infants up to school age. METHODS: From October 2004 to September 2008, in the German federal state of Lower Saxony, 437 infants born at a gestational age less than 28 weeks were followed up at the ages of 2 and 5 years, and some at the age of 10 years. The 5-year follow-up data were collated with the peri- and neonatological parameters and compared with the 2- and 10-year follow-up data...
December 26, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28122664/preterm-birth-inflammation-fetal-injury-and-treatment-strategies
#6
Ashley K Boyle, Sara F Rinaldi, Jane E Norman, Sarah J Stock
Preterm birth (PTB) is the leading cause of childhood mortality in children under 5 and accounts for approximately 11% of births worldwide. Premature babies are at risk of a number of health complications, notably cerebral palsy, but also respiratory and gastrointestinal disorders. Preterm deliveries can be medically indicated/elective procedures or they can occur spontaneously. Spontaneous PTB is commonly associated with intrauterine infection/inflammation. The presence of inflammatory mediators in utero has been associated with fetal injury, particularly affecting the fetal lungs and brain...
December 2, 2016: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28042670/the-genetic-basis-of-cerebral-palsy
#7
REVIEW
Michael C Fahey, Alastair H Maclennan, Doris Kretzschmar, Jozef Gecz, Michael C Kruer
Although prematurity and hypoxic-ischaemic injury are well-recognized contributors to the pathogenesis of cerebral palsy (CP), as many as one-third of children with CP may lack traditional risk factors. For many of these children, a genetic basis to their condition is suspected. Recent findings have implicated copy number variants and mutations in single genes in children with CP. Current studies are limited by relatively small patient numbers, the underlying genetic heterogeneity identified, and the paucity of validation studies that have been performed...
January 1, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27958310/sga-as-a-risk-factor-for-cerebral-palsy-in-moderate-to-late-preterm-infants-a-system-review-and-meta-analysis
#8
Mengwen Zhao, Hongmei Dai, Yuanying Deng, Lingling Zhao
Small for gestational age (SGA) is an established risk factor for cerebral palsy (CP) in term infants. However, there is conflicting data on the association between SGA and CP in moderate to late preterm infants. The aim of the article was to explore the relationship between SGA and CP in the moderate to late preterm infants and its strength by meta-analysis. We performed a system search in OVID (EMBASE and MEDLINE) and WANFANG from inception to May 2016. The study-specific risk estimates were pooled using the random-effect model...
December 13, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27942155/the-effects-of-neck-and-trunk-stabilization-exercises-on-upper-limb-and-visuoperceptual-function-in-children-with-cerebral-palsy
#9
Ji-Won Shin, Gui-Bin Song
[Purpose] The present study aimed to investigate the effects of neck and trunk stabilization exercises on upper limb and visuoperceptual function in children with cerebral palsy. The Jebson-Taylor hand function test and the Korean Developmental Test of Visual Perception-2 (K-DTVP-2) test were utilised. [Subjects and Methods] The study subjects were 11 schoolchildren who had paraplegia caused by premature birth, and who had been diagnosed with periventricular leukomalacia. Kinesitherapy was implemented in individual children for eight weeks, twice a week, for 45 minutes at a time...
November 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27906083/neonatal-diffusion-tensor-brain-imaging-predicts-later-motor-outcome-in-preterm-neonates-with-white-matter-abnormalities
#10
Do-Yeon Kim, Hyun-Kyung Park, Nam-Su Kim, Se-Jin Hwang, Hyun Ju Lee
BACKGROUND: White matter (WM) abnormalities associated with prematurity are one of the most important causes of neurological disability that involves spastic motor deficits in preterm newborns. This study aimed to evaluate regional microstructural changes in diffusion tensor imaging (DTI) associated with WM abnormalities. METHODS: We prospectively studied extremely low birth weight (ELBW; <1000 g) preterm infants who were admitted to the Neonatal Intensive Care Unit of Hanyang University Hospital between February 2011 and February 2014...
December 1, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27904971/mutations-in-slc5a6-associated-with-brain-immune-bone-and-intestinal-dysfunction-in-a-young-child
#11
Veedamali S Subramanian, Alexandru R Constantinescu, Paul J Benke, Hamid M Said
The human sodium-dependent multivitamin transporter (hSMVT) is a product of the SLC5A6 gene and mediates biotin, pantothenic acid, and lipoate uptake in a variety of cellular systems. We report here the identification of mutations R94X, a premature termination, and R123L, a dysfunctional amino acid change, both in exon 3 of the SLC5A6 gene in a child using whole genome-scanning. At 15 months of age, the child showed failure to thrive, microcephaly and brain changes on MRI, cerebral palsy and developmental delay, variable immunodeficiency, and severe gastro-esophageal reflux requiring a gastrostomy tube/fundoplication, osteoporosis, and pathologic bone fractures...
February 2017: Human Genetics
https://www.readbyqxmd.com/read/27899304/caffeine-for-apnea-of-prematurity-effects-on-the-developing-brain
#12
REVIEW
Anzari Atik, Richard Harding, Robert De Matteo, Delphi Kondos-Devcic, Jeanie Cheong, Lex W Doyle, Mary Tolcos
Caffeine is a methylxanthine that is widely used to treat apnea of prematurity (AOP). In preterm infants, caffeine reduces the duration of respiratory support, improves survival rates and lowers the incidence of cerebral palsy and cognitive delay. There is, however, little evidence relating to the immediate and long-term effects of caffeine on brain development, especially at the cellular and molecular levels. Experimental data are conflicting, with studies showing that caffeine can have either adverse or benefical effects in the developing brain...
January 2017: Neurotoxicology
https://www.readbyqxmd.com/read/27899082/interventions-to-improve-gross-motor-performance-in-children-with-neurodevelopmental-disorders-a-meta-analysis
#13
Barbara R Lucas, Elizabeth J Elliott, Sarah Coggan, Rafael Z Pinto, Tracy Jirikowic, Sarah Westcott McCoy, Jane Latimer
BACKGROUND: Gross motor skills are fundamental to childhood development. The effectiveness of current physical therapy options for children with mild to moderate gross motor disorders is unknown. The aim of this study was to systematically review the literature to investigate the effectiveness of conservative interventions to improve gross motor performance in children with a range of neurodevelopmental disorders. METHODS: A systematic review with meta-analysis was conducted...
November 29, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27776846/-prevention-of-preterm-birth-complications-by-antenatal-corticosteroid-administration
#14
T Schmitz
OBJECTIVE: To evaluate short- and long-term benefits and risks associated with antenatal administration of a single course of corticosteroids and the related strategies: multiple and rescue courses. METHODS: The PubMed database, the Cochrane Library and the recommendations from the French and foreign obstetrical societies or colleges have been consulted. RESULTS: Antenatal administration of a single course of corticosteroids before 34 weeks of gestation is associated in the neonatal period with a significant reduction of respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH), necrotizing enterocolitis (NEC) and death (LE1), and in possibly childhood with a reduction of cerebral palsy and increased psychomotor development index and intact survival (LE3)...
December 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/27758929/determinants-of-developmental-outcomes-in-a-very-preterm-canadian-cohort
#15
Anne Synnes, Thuy Mai Luu, Diane Moddemann, Paige Church, David Lee, Michael Vincer, Marilyn Ballantyne, Annette Majnemer, Dianne Creighton, Junmin Yang, Reginald Sauve, Saroj Saigal, Prakesh Shah, Shoo K Lee
OBJECTIVES: Identify determinants of neurodevelopmental outcome in preterm children. METHODS: Prospective national cohort study of children born between 2009 and 2011 at <29 weeks gestational age, admitted to one of 28 Canadian neonatal intensive care units and assessed at a Canadian Neonatal Follow-up Network site at 21 months corrected age for cerebral palsy (CP), visual, hearing and developmental status using the Bayley Scales of Infant and Toddler Development-Third Edition (Bayley-III)...
October 6, 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/27723868/association-of-neurodevelopmental-outcomes-and-neonatal-morbidities-of-extremely-premature-infants-with-differential-exposure-to-antenatal-steroids
#16
Sanjay Chawla, Girija Natarajan, Seetha Shankaran, Athina Pappas, Barbara J Stoll, Waldemar A Carlo, Shampa Saha, Abhik Das, Abbot R Laptook, Rosemary D Higgins
Importance: Many premature infants are born without exposure to antenatal steroids (ANS) or with incomplete courses. This study evaluates the dose-dependent effect of ANS on rates of neonatal morbidities and early childhood neurodevelopmental outcomes of extremely premature infants. Objective: To compare rates of neonatal morbidities and 18- to 22-month neurodevelopmental outcomes of extremely premature infants exposed to no ANS or partial or complete courses of ANS...
December 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27650433/igf-1-in-retinopathy-of-prematurity-a-cns-neurovascular-disease
#17
REVIEW
Raffael Liegl, Chatarina Löfqvist, Ann Hellström, Lois E H Smith
The retina is part of the central nervous system and both the retina as well as the brain can suffer from severe damage after very preterm birth. Retinopathy of prematurity is one of the major causes of blindness in these children and brain neuronal impairments including cognitive defects, cerebral palsy and intraventricular hemorrhage (IVH) are also complications of very preterm birth. Insulin-like growth factor 1 (IGF-1) acts to promote proliferation, maturation, growth and survival of neural cells. Low levels of circulating IGF-1 are associated with ROP and defects in the IGF-1 gene are associated with CNS disorders including learning deficits and brain growth restriction...
November 2016: Early Human Development
https://www.readbyqxmd.com/read/27591975/relationship-between-brain-lesion-characteristics-and-communication-in-preschool-children-with-cerebral-palsy
#18
Andrea Coleman, Simona Fiori, Kelly A Weir, Robert S Ware, Roslyn N Boyd
BACKGROUND: MRI shows promise as a prognostic tool for clinical findings such as gross motor function in children with cerebral palsy(CP), however the relationship with communication skills requires exploration. AIMS: To examine the relationship between the type and severity of brain lesion on MRI and communication skills in children with CP. METHODS AND PROCEDURES: 131 children with CP (73 males(56%)), mean corrected age(SD) 28(5) months, Gross Motor Functional Classification System distribution: I=57(44%), II=14(11%), III=19(14%), IV=17(13%), V=24(18%)...
November 2016: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/27552089/chorioamnionitis-at-birth-does-not-increase-the-risk-of-neurodevelopmental-disability-in-premature-infants-with-bronchopulmonary-dysplasia
#19
Rani A Bashir, Vineet Bhandari, Sakeer Vayalthrikkovil, Yacov Rabi, Amuchou Soraisham, Selphee Tang, Essa Al Awad, Abhay Lodha
AIM: To compare preterm infants with no bronchopulmonary dysplasia (BPD), BPD with chorioamnionitis (BPDC) and BPD with no chorioamnionitis (BPDNC) for the association with neurodevelopmental disability (NDD) at three years corrected age. METHODS: Demographic and outcome data of infants with birthweight (BW) ≤1250 g born during two epochs (1995-2000 and 2002-2007 with an interim washout period of one year) were compared on the basis of whether they had BPD, chorioamnionitis or both...
November 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27538596/optic-nerve-morphology-as-marker-for-disease-severity-in-cerebral-palsy-of-perinatal-origin
#20
Deepta Ghate, Vettaikorumakankav Vedanarayanan, Abdulbaset Kamour, James J Corbett, Sachin Kedar
BACKGROUND: It is difficult to predict the neurologic outcome and ambulatory status in children with perinatal neurologic insult until 2-5years age. This study aims to correlate clinical optic nerve head (ONH) findings-cupping, pallor and hypoplasia, with gestational period and neurologic (motor) outcomes in patients with cerebral palsy (CP) from perinatal insults. METHODS: 54 consecutive patients with CP from perinatal insults were enrolled. Patients with intraocular disease, retinopathy of prematurity and hydrocephalus were excluded...
September 15, 2016: Journal of the Neurological Sciences
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