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Bladder cancer, cystectomy

Anobel Y Odisho, Ruth Etzioni, John L Gore
BACKGROUND: Safety-net hospitals (SNHs) care for more patients of low socioeconomic status (SES) than non-SNHs and are disproportionately punished under SES-naive Medicare readmission risk-adjustment models. This study was designed to develop a risk-adjustment framework that incorporates SES and to assess the impact on readmission rates. METHODS: California Office of Statewide Health Planning and Development data from 2007 to 2011 were used to identify patients undergoing radical cystectomy (RC) for bladder cancer (n = 3771) or partial nephrectomy (PN; n = 5556) or radical nephrectomy (RN; n = 13,136) for kidney cancer...
June 15, 2018: Cancer
Sebastien Rinaldetti, Eugen Rempel, Thomas Stefan Worst, Markus Eckstein, Annette Steidler, Cleo Aaron Weiss, Christian Bolenz, Arndt Hartmann, Philipp Erben
Background: Transcriptome expression studies identified distinct muscle invasive bladder cancer (MIBC) subtypes closely related with breast cancer subclasses. Here we developed a sensitive quantification method for MIBC subclassification (luminal, basal, p53-like). In addition, the subtype specific expression of drug targets has been investigated. Methods: Absolute quantification (nCounter) of a 64-gene panel was performed on MIBC patients (n=47) treated exclusively with radical cystectomy (RC)...
May 25, 2018: Oncotarget
Gregory A Joice, Meera R Chappidi, Hiten D Patel, Max Kates, Nikolai A Sopko, C J Stimson, Phillip M Pierorazio, Trinity J Bivalacqua
OBJECTIVES: To investigate the impact of continent urinary diversion on readmissions and hospital costs in a nationally representative sample of radical cystectomies (RC) performed in the United States. MATERIALS & METHODS: The 2010-2014 Nationwide Readmissions Database was queried for patients with a diagnosis of bladder cancer who underwent RC. We identified patients undergoing continent (neobladder or continent cutaneous reservoir) or incontinent (ileal conduit) diversions...
June 13, 2018: BJU International
Edwin J Aslim, Min Hoe Chew, Ghee Kheng Chew, Lui Shiong Lee
BACKGROUND: Pelvic exenteration (PE) for locally advanced pelvic malignancy requires a multi-disciplinary approach and is associated with significant morbidity. Urinary reconstruction forms a major component of this procedure. The aim of the study is to review the urological outcomes following PE in a newly established pelvic oncology unit, to compare with those following radical cystectomy (RC) for bladder cancer. METHODS: Patients were identified from prospectively maintained PE and bladder cancer databases, inclusive of all cases performed between January 2012 and December 2016...
June 12, 2018: ANZ Journal of Surgery
Matthew T McLeay, Lindsey Ellis, Stephen H Weinstein, Katie S Murray
We report a patient that had a prior radical prostatectomy and negative PSA levels for two years and subsequently developed bladder cancer requiring radical cystectomy with mixed lymph nodes on final pathology. The nodes were found to be positive for both metastatic urothelial cell carcinoma and metastatic prostatic adenocarcinoma based on immunohistochemical staining. Treatment for metastatic bladder cancer was pursued after radical cystectomy recovery.
July 2018: Urology Case Reports
Dharma Ram, Suhas K Rajappa, Sudhir Rawal, Amitabh Singh, Kailash Chand Sharma, Ajay Kumar Dewan
Incidental prostatic carcinoma on radical cystectomy histology specimens is not an uncommon entity and managing such cases is still controversial. Classification into clinically significant and insignificant cancers by Epstein based on the assumption that one is more likely to affect the survival than the other is not universally accepted. We conducted this retrospective analysis with the aim to find out the role of dichotomization of incidental prostatic cancer into such classification. Patient's data were retrospectively reviewed from January 2013 to December 2014...
June 2018: Indian Journal of Surgical Oncology
Lotte Linnemann Rønfeldt, Dorthe Hjort Jakobsen, Henrik Kehlet, Henriette Lipczak, Kasper Wennerwaldt
INTRODUCTION: Clinical practice guidelines (CPGs) support enhanced post-operative recovery and decrease morbidity. In addition, patient information leaflets (PILs) are associated with enhanced overall outcomes and improved patient satisfaction. The aim of this study was to provide an overview of the quality of CPGs and PILs in cancer surgery departments undertaking pulmonary lobectomy, nephrectomy, cystectomy, whipples, colorectal and ovarian surgery. METHODS: We conducted a cross-sectional descriptive study within 44 surgical departments in six cancer subspecialties: lung (n = 4), kidney (n = 9), bladder (n = 5), pancreas (n = 4), colorectal (n = 18) and ovarian (n = 4)...
June 2018: Danish Medical Journal
J F Wang, X F Zhou, D B Fang, Z M Wu, Z S Ding, X Chen, N B Liu
Objective: To explore the effect of radical TURBT combing with concomitant chemo-radiotherapy for muscle-invasive bladder cancer (MIBC). Methods: From 2010 to 2015, 73 patients were diagnosed as MIBC, in which 28 patients (TMT Group) received tri-modality bladder sparing treatment, including 21 males and 7 females, mean age (68.9±8.9) yr. There were 16 cases of T(2), 12 cases of T(3). 45 patients (RC Group) received radical cystectomy (RC), including 32 males and 13 females, mean age (66.3±9.6) yr. There were 25 cases of T(2), 18 cases of T(3) and 2 cases of T(4a)...
May 29, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Timothy D Lyon, Matthew K Tollefson, Paras H Shah, Katherine Bews, Igor Frank, R Jeffrey Karnes, R Houston Thompson, Elizabeth B Habermann, Stephen A Boorjian
PURPOSE: To determine whether the rate of venous thromboembolism (VTE) following radical cystectomy (RC) is changing overtime. MATERIALS AND METHODS: The American College of Surgeons National Surgical Quality Improvement Program database was used to identify patients who underwent RC for bladder cancer from 2011 to 2016. VTE was defined as pulmonary embolism or deep vein thrombosis within 30 days of RC. VTE rate by year was assessed using the Cochran-Armitage test for trend...
June 6, 2018: Urologic Oncology
Ryo Ataka, Shinsuke Sato, Kazuyosi Matsubara, Masakazu Takagi, Ichiro Chihara, Naoki Kohei, Koji Yoshimura
A 74-year-old man presented at our hospital with complaints of abdominal pain, nausea, and vomiting. He had undergone laparoscopic radical cystectomy and ileal conduit for urinary bladder cancer 1 month earlier. The patient had abdominal distention, resonant sounds on percussion, and diffuse abdominal tenderness without rebound or guarding. Abdominal CT revealed dilated jejunal loops herniated through a cord-like structure. Based on these findings, emergency surgery was performed, and intestinal dilatation into the space between the ureter, the ileal conduit, and the sacral bone was detected...
June 7, 2018: Asian Journal of Endoscopic Surgery
N Vasdev, H Zargar, J P Noël, R Veeratterapillay, A S Fairey, L S Mertens, C P Dinney, M C Mir, L M Krabbe, M S Cookson, N E Jacobsen, N M Gandhi, J Griffin, J S Montgomery, E Y Yu, E Xylinas, N J Campain, W Kassouf, M A Dall'Era, J A Seah, C E Ercole, S Horenblas, S S Sridhar, J S McGrath, J Aning, S F Shariat, J L Wright, T M Morgan, T J Bivalacqua, S North, D A Barocas, Y Lotan, P Grivas, A J Stephenson, J B Shah, B W van Rhijn, S Daneshmand, P E Spiess, J M Holzbeierlein, A Thorpe, P C Black
BACKGROUND: Cisplatin-based neoadjuvant chemotherapy (NAC) for muscle invasive bladder cancer improves all-cause and cancer specific survival. We aimed to evaluate whether the detection of carcinoma in situ (CIS) at the time of initial transurethral resection of bladder tumor (TURBT) has an oncological impact on the response to NAC prior to radical cystectomy. PATIENTS AND METHODS: Patients were identified retrospectively from 19 centers who received at least three cycles of NAC or induction chemotherapy for cT2-T4aN0-3M0 urothelial carcinoma of the bladder followed by radical cystectomy between 2000 and 2013...
June 7, 2018: World Journal of Urology
A Soave, S Riethdorf, R Dahlem, S Minner, L Weisbach, O Engel, M Fisch, K Pantel, M Rink
OBJECTIVES: To investigate for the presence of circulating tumor cells (CTC) in patients with variant urothelial carcinoma of the bladder (UCB) histology treated with radical cystectomy (RC), and to determine their impact on oncological outcomes. PATIENTS AND METHODS: We, prospectively, collected data of 188 patients with UCB treated with RC without neoadjuvant chemotherapy. Pathological specimens were meticulously reviewed for pure and variant UCB histology. Preoperatively collected blood samples (7...
June 4, 2018: Urologic Oncology
François Audenet, Nikhil Waingankar, Bart S Ferket, Scot A Niglio, Kathryn E Marqueen, John P Sfakianos, Matthew D Galsky
PURPOSE: To investigate the characteristics and outcomes of patients with muscle-invasive bladder cancer (MIBC) treated with transurethral resection (TUR) plus chemotherapy alone in a large observational cohort reflecting the continuum of practice settings in the United States. MATERIALS AND METHODS: Within the National Cancer Database (2004-2015), we identified 1,538 patients treated with TUR plus multi-agent chemotherapy as definitive treatment for cT2-T4aN0M0 urothelial carcinoma of the bladder...
June 4, 2018: Journal of Urology
Sumeet Bhanvadia, Kayvan Kazerouni, Soroush T Bazargani, Gus Miranda, Jie Cai, Siamak Daneshmand, Hooman Djaladat
PURPOSE: To validate the relationship between ABO blood type and risk of VTE post-RC in a large retrospective database. METHODS: Patients with urothelial bladder cancer (UBC) who underwent RC (intent-to-cure) for whom ABO blood type was available between 2003 and 2015 were identified from our IRB-approved database. VTE was defined as deep vein thrombosis (DVT) or pulmonary embolism (PE) within 90 days of surgery. VTE prophylaxis consisted of immediate postoperative Coumadin (2003-2009), unfractionated heparin (UFH) during hospitalization (2009-2015), and UFH during hospitalization plus 4 weeks of enoxaparin after discharge (2013-2015)...
June 6, 2018: World Journal of Urology
Adrian S Fairey, Ryan Mclarty
No abstract text is available yet for this article.
June 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
P Rajwa, M Życzkowski, A Paradysz, K Bujak, P Bryniarski
OBJECTIVE: Our aim was to evaluate the association between preoperative LMR, PLR, NLR, dNLR, and survival of urothelial bladder cancer (UBC) patients treated with radical cystectomy (RC). We also analyzed the relationship between preoperative blood-based inflammatory biomarkers' levels and postoperative in-hospital complications. PATIENTS AND METHODS: This retrospective study included 144 UBC patients, who underwent RC between 2003 and 2015. The study endpoints were cancer-specific survival (CSS) and overall survival (OS)...
May 2018: European Review for Medical and Pharmacological Sciences
G L Yang, L H Zhang, Q Liu, Z L Wang, X H Duan, Y R Huang, J J Bo
BACKGROUND: Management of high-grade T1 (formerly T1G3) bladder cancer continues to be controversial. Should patients with T1G3 bladder cancer have an immediate radical cystectomy or should they receive intravesical bacillus Calmette-Guérin preserving bladder? Gemcitabine and cisplatin (GC) adjuvant chemotherapy may help to strike a balance between intravesical and early cystectomy. For purposes of this study, we continue to refer high-grade T1 lesion as "T1G3." OBJECTIVE: To evaluate the characteristics and the long-term outcome of GC adjuvant chemotherapy in T1G3 bladder cancer after transurethral resection of bladder tumor (TURBT)...
May 30, 2018: Urologic Oncology
Anja Rabien, Nadine Ratert, Anica Högner, Andreas Erbersdobler, Klaus Jung, Thorsten H Ecke, Ergin Kilic
Bladder cancer still requires improvements in diagnosis and prognosis, because many of the cases will recur and/or metastasize with bad outcomes. Despite ongoing research on bladder biomarkers, the clinicopathological impact and diagnostic function of miRNA maturation regulators Drosha and Argonaute proteins AGO1 and AGO2 in urothelial bladder carcinoma remain unclear. Therefore, we conducted immunohistochemical investigations of a tissue microarray composed of 112 urothelial bladder carcinomas from therapy-naïve patients who underwent radical cystectomy or transurethral resection and compared the staining signal with adjacent normal bladder tissue...
May 31, 2018: International Journal of Molecular Sciences
Jan Ebbing, Robin Colja Heckmann, Justin William Collins, Kurt Miller, Barbara Erber, Frank Friedersdorff, Tom Florian Fuller, Jonas Busch, Hans Helge Seifert, Peter Ardelt, Christian Wetterauer, Abolfazl Hosseini, Florian Jentzmik, Carsten Kempkensteffen
To evaluate the oncological results, associated complications, and postoperative health-related quality of life (HR-QoL) in patients treated with partial cystectomy (PC) for muscle-invasive bladder cancer (MIBC). 27 patients who underwent open PC for cT2 MIBC were included. A simple Cox's proportional hazards regression model was used to assess the association of several potential prognostic factors with survival. Postoperative HR-QoL was assessed with the EORTC (European Organisation for the Research and Treatment of Cancer) QLQ-C30 questionnaire version 3...
May 30, 2018: Scientific Reports
Sebastiano Nazzani, Elio Mazzone, Felix Preisser, Marco Bandini, Zhe Tian, Michele Marchioni, Dario Ratti, Gloria Motta, Kevin Christopher Zorn, Alberto Briganti, Shahrokh F Shariat, Emanuele Montanari, Luca Carmignani, Pierre I Karakiewicz
INTRODUCTION: Radical cystectomy represents the standard of care for muscle invasive bladder cancer (MIBC). Due to its novelty the use of robotic radical cystectomy (RARC) is still under debate. We examined intraoperative and postoperative morbidity and mortality as well as impact on length of stay (LOS) and total hospital charges (THCGs) of RARC compared to open radical cystectomy (ORC). MATERIAL AND METHODS: Within National Inpatient Sample (NIS) (2008-2013), we identified patients with non-metastatic bladder cancer treated with either ORC or RARC...
May 30, 2018: Journal of Endourology
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