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Bladder cancer, cystectomy

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https://www.readbyqxmd.com/read/28213861/peri-operative-allogeneic-blood-transfusion-and-outcomes-after-radical-cystectomy-a-population-based-study
#1
D Robert Siemens, Melanie T Jaeger, Xuejiao Wei, Francisco Vera-Badillo, Christopher M Booth
INTRODUCTION: To describe factors associated with peri-operative blood transfusion (PBT) at radical cystectomy (RC) for patients with bladder cancer and evaluate its association on both early and late outcomes. METHODS: Electronic records of treatment and surgical pathology reports were linked to the population-based Ontario Cancer Registry to identify all patients who underwent RC between 2000 and 2008. Modified Poisson regression model was used to determine the factors associated with PBT...
February 17, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28213097/self-assembled-tumor-targeting-hyaluronic-acid-nanoparticles-for-photothermal-ablation-in-orthotopic-bladder-cancer
#2
Tingsheng Lin, Ahu Yuan, Xiaozhi Zhao, Huibo Lian, Junlong Zhuang, Wei Chen, Qing Zhang, Guangxiang Liu, Shiwei Zhang, Wei Chen, Wenmin Cao, Chengwei Zhang, Jinhui Wu, Yiqiao Hu, Hongqian Guo
: Bladder cancer is one of the most frequent malignancies in the urinary system. Radical cystectomy is inevitable when bladder cancer progresses to a muscle-invasive disease. However, cystectomy still causes a high risk of death and a low quality of life (such as ureter-abdomen ostomy, uroclepsia for ileal-colon neobladder). Therefore, more effective treatments as well as bladder preservation are needed. We developed self-assembled tumor-targeting hyaluronic acid-IR-780 nanoparticles for photothermal ablation in over-expressing CD44 (the receptor for HA) bladder cancer, which show high tumor selectivity, high treatment efficacy, good bioavailability, and excellent biocompatibility...
February 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28209455/port-site-metastases-after-robotic-radical-cystectomy-a-systematic-review-and-management-options
#3
REVIEW
Pramit Khetrapal, Wei Shen Tan, Benjamin Lamb, Senthil Nathan, Tim Briggs, Arjun Shankar, Navin Ramachandran, Alex Freeman, Anita Mitra, John D Kelly
BACKGROUND: Port-site metastases (PSMs) are a rare occurrence after robotic surgery. For robot-assisted radical cystectomy (RARC), isolated cases have been reported but management has not been previously described. We present a case of PSM that occurred after RARC and report the results of our systematic review of previously reported PSMs and describe the treatment options. Search Criteria and Methods: We describe a case of a PSM in a 55-year-old man who had undergone intracorporeal RARC...
June 29, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28209079/acid-base-disorders-after-orthotopic-bladder-replacement-comparison-of-an-ileal-neobladder-and-an-ileal-conduit
#4
AJin Cho, Seung Min Lee, Jung Woo Noh, Don Kyoung Choi, Yongseong Lee, Sung Tae Cho, Ki Kyung Kim, Young Goo Lee, Young Ki Lee
OBJECTIVES: For many years, creation of an orthotopic neobladder after cystectomy has been popular. In the present study, we measured the extent of metabolic acidosis in patients with ileal neobladders compared with ileal conduits and defined risk factors for development of metabolic acidosis. METHODS: We retrospectively studied 95 patients, who underwent radical cystectomy and urinary diversion to treat invasive bladder cancer from January 2001 to December 2014 at Hallym University Kangnam Sacred Heart Hospital, through investigation of acid-base balance, serum electrolyte levels and renal function one month and one year after operation...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28207595/association-between-anesthesiology-volumes-and-early-and-late-outcomes-after-cystectomy-for-bladder-cancer-a-population-based-study
#5
Melanie T Jaeger, D Robert Siemens, Xuejiao Wei, Paul Peng, Christopher M Booth
BACKGROUND: Hospital and surgeon volume are related to postoperative complications and long-term survival after radical cystectomy. Here, we describe the relationships between these provider characteristics and anesthesiologist volumes on early and late outcomes after radical cystectomy for bladder cancer. METHODS: Records of treatment and surgical pathology reports were linked to the population-based Ontario Cancer Registry to identify all patients with radical cystectomy in Ontario during 1994 to 2008...
February 15, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28191808/chemoradiation-for-organ-preservation-in-the-treatment-of-muscle-invasive-bladder-cancer-our-institutional-experience
#6
Sweety Gupta, Sudarsan De, Nitin Leekha, Shailesh Chand Sahay, Prekshi Chaudary, Shashank Srinivasan, Malay Nandy
AIM: To assess outcome of chemoradiotherapy for organ preservation in muscle invasive bladder cancer. MATERIAL AND METHODS: 41 patients treated between January 2010 to January 2015 were evaluated in the present study. All patients T staged ranging from cT2-T4a and had undergone maximal transurethral resection of bladder tumour (TURBT). After maximum bladder tumour resection patients were treated with Radiotherapy with or without concurrent chemotherapy. 8 weeks after completion of treatment response was assessed by check cystoscopy, urine cytology and CECT scan Abdomen...
September 2016: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28187997/-adjuvant-radiotherapy-for-bladder-cancer-in-patients-with-risk-of-locoregional-recurrence-who-what-and-how
#7
P Sargos, S Larré, O Chapet, I Latorzeff, A Fléchon, G Roubaud, M Orré, S Belhomme, P Richaud
Radical cystectomy with extended pelvic lymph node dissection remains the standard of care for non-metastatic muscle-invasive bladder cancer. Locoregional control is a key factor in the outcome of patients since it is related to overall survival, metastasis-free survival and specific survival. Locoregional recurrence rate is directly correlated to pathological results and the quality of lymphadenectomy. In addition, while pre- or postoperative chemotherapy improved overall survival, it showed no impact on locoregional recurrence-free survival...
February 7, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28182321/detection-and-oncological-effect-of-circulating-tumour-cells-in-patients-with-variant-urothelial-carcinoma-histology-treated-with-radical-cystectomy
#8
Armin Soave, Sabine Riethdorf, Roland Dahlem, Sarah Minner, Lars Weisbach, Oliver Engel, Margit Fisch, Klaus Pantel, Michael Rink
OBJECTIVES: To investigate for the presence of circulating tumour cells (CTC) in patients with variant urothelial carcinoma of the bladder (UCB) histology treated with radical cystectomy (RC), and to determine their impact on oncological outcomes. PATIENTS AND METHODS: We prospectively collected data of 188 patients with UCB treated with RC without neoadjuvant chemotherapy. Pathological specimens were meticulously reviewed for pure and variant UCB histology. Preoperatively collected blood samples (7...
February 9, 2017: BJU International
https://www.readbyqxmd.com/read/28163086/long-term-survival-outcomes-with-intravesical-nanoparticle-albumin-bound-paclitaxel-for-recurrent-nonmuscle-invasive-bladder-cancer-after-previous-bacillus-calmette-gu%C3%A3-rin-therapy
#9
Dennis J Robins, Wilson Sui, Justin T Matulay, Rashed Ghandour, Christopher B Anderson, G Joel DeCastro, James M McKiernan, John K Lattimer
OBJECTIVE: To report long-term follow up results of a phase II trial of salvage intravesical nanoparticle albumin bound (nab)-paclitaxel for patients with recurrent non-muscle invasive bladder cancer after previous intravesical Bacillus Calmette-Guérin (BCG) therapy. METHODS: This was a phase II trial investigating the use of intravesical nab-paclitaxel in patients with recurrent Tis, Ta, and T1 urothelial carcinoma who failed at least one prior induction course of intravesical BCG...
February 2, 2017: Urology
https://www.readbyqxmd.com/read/28162943/impact-of-intra-and-postoperative-blood-transfusion-on-the-incidence-timing-and-pattern-of-disease-recurrence-after-radical%C3%A2-cystectomy
#10
Marco Moschini, Francesco Soria, Mohammad Abufaraj, Beat Foerster, David D'Andrea, Rocco Damiano, Tobias Klatte, Francesco Montorsi, Alberto Briganti, Renzo Colombo, Andrea Gallina, Shahrokh F Shariat
BACKGROUND: The administration of blood transfusion (BT) has been associated with a decrease in survival expectancies in patients treated with radical cystectomy (RC), as a consequence of the immunosuppressive effect mediated by BT. We sought therefore to evaluate if the usage of BT may influence the risk and pattern location of distant recurrences after RC, which may be influenced by this effect. METHODS: Data from 2 independent cohorts of consecutive patients with bladder cancer treated with RC were analyzed...
January 11, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28162942/can-the-preoperative-neutrophil-to-lymphocyte-ratio-significantly-predict-the-conditional-survival-probability-in-muscle-invasive-bladder-cancer-patients-undergoing-radical-cystectomy
#11
Minyong Kang, Ulanbek J Balpukov, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Ja Hyeon Ku
INTRODUCTION: The present study investigated the prognostic value of the preoperative neutrophil-to-lymphocyte ratio (NLR) in bladder cancer patients undergoing radical cystectomy (RC), with a focus on the conditional survival (CS) estimates over time after surgery. MATERIALS AND METHODS: We analyzed 385 bladder cancer patients who underwent RC from 1999 to 2012. The patients were classified into 2 groups according to the preoperative NLR (< 2.5 vs. ≥ 2.5)...
January 9, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28149936/change-in-psoas-muscle-volume-as-a-predictor-of-outcomes-in-patients-treated-with-chemotherapy-and-radical-cystectomy-for-muscle-invasive-bladder-cancer
#12
Homayoun Zargar, Nima Almassi, Evan Kovac, Cesar Ercole, Erick Remer, Brian Rini, Andrew Stephenson, Jorge A Garcia, Petros Grivas
Objective: Sarcopenia, or the age-related loss of skeletal muscle mass and function, has been investigated as a potential marker of adverse outcomes among surgical patients. Our aim was to assess for changes in psoas muscle volume (PMV) following administration of neoadjuvant chemotherapy (NAC) in patients with bladder cancer and to examine whether changes in PMV following NAC are predictive of perioperative complications, pathologic response or survival. Methods: During the period of 2009-2013, patients undergoing NAC and radical cystectomy (RC) at our institution with pre and post NAC cross sectional images available were included...
January 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/28149933/utility-of-clinical-risk-stratification-in-the-selection-of-muscle-invasive-bladder-cancer-patients-for-neoadjuvant-chemotherapy-a-retrospective-cohort-study
#13
Friedrich-Carl von Rundstedt, Douglas A Mata, Oleksandr N Kryvenko, Anup A Shah, Iny Jhun, Seth P Lerner
Introduction: Level I evidence supports the use of cisplatin-based neoadjuvant chemotherapy (NAC) for muscle-invasive bladder cancer prior to radical cystectomy (RC). On average, 30-40% of patients achieve a complete pathologic response (i.e., stage pT0) after receiving NAC. Some centers risk-stratify patients, suggesting that there may be a higher-risk population that would derive the most benefit from NAC. Recently, a risk-stratification model developed at M.D. Anderson Cancer Center (MDACC) specified criteria for clinical staging and patient selection for NAC...
January 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/28149931/the-rationale-for-post-operative-radiation-in-localized-bladder-cancer
#14
REVIEW
Brian C Baumann, Paul Sargos, Libni J Eapen, Jason A Efstathiou, Ananya Choudhury, Amit Bahl, Vedang Murthy, Leslie K Ballas, Valérie Fonteyne, Pierre M Richaud, Mohamed S Zaghloul, John P Christodouleas
Local-regional recurrence for patients with ≥pT3 disease after radical cystectomy is a significant problem. Chemotherapy has not been shown to reduce the risk of local-regional recurrences in randomized prospective trials, and salvage therapies for local-regional failure are rarely successful. There is promising evidence, particularly from a recent Egyptian NCI trial, that radiation therapy plus chemotherapy can significantly reduce local recurrences compared to chemotherapy alone, and that this improvement in local-regional control may translate to meaningful improvements in disease-free and overall survival with acceptable toxicity...
January 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/28145751/diagnostic-accuracy-of-hexaminolevulinate-in-a-cohort-of-patients-undergoing-radical-cystectomy
#15
Vincenzo Pagliarulo, Alba Stefano, Maria Filomena Gallone, Savino Di Stasi, Luigi Cormio, Tommasangelo Petitti, Maurizio Buscarini, Paolo Minafra, Giuseppe Carrieri
Purpose To compare the accuracy of white light cystoscopy (WLC) and blue light cystoscopy (BLC) in a cohort of patients undergoing radical cystectomy (RC) for previously resected urothelial bladder cancer (UCB). Patients and methods A cohort of patients undergoing RC received WLC and BLC prior radical surgery. To evaluate the residual tumor rate, the bladder was inspected after its removal and normal appearing mucosa sampled for histologic analysis. Lesions detected under WLC, BLC, or both, as well as biopsy samples from normal appearing mucosa, were all recorded separately...
February 1, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28139446/patient-frailty-and-discharge-disposition-following-radical-cystectomy
#16
Jeffrey A Pearl, Dattatraya Patil, Christopher P Filson, Shipra Arya, Mehrdad Alemozaffar, Viraj A Master, Kenneth Ogan
BACKGROUND: Patients with bladder cancer who are treated with cystectomy are at high risk for complications and prolonged length of stay. This population tends to be of advanced age with underlying comorbidities, and thus more likely to have decreased physiologic reserve (ie, frailty). Our objective was to evaluate the relationship between frailty and discharge disposition for patients with bladder cancer treated with cystectomy. MATERIALS AND METHODS: Using data from the National Surgical Quality Improvement Program, we identified patients with bladder cancer undergoing cystectomy (2011-2014)...
January 5, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28139370/lymph-node-density-vs-the-american-joint-committee-on-cancer-tnm-nodal-staging-system-in-node-positive-bladder-cancer-in-patients-undergoing-extended-or-super-extended-pelvic-lymphadenectomy
#17
Donghyun Lee, Sangjun Yoo, Dalsan You, Bumsik Hong, Yong Mee Cho, Jun Hyuk Hong, Choung-Soo Kim, Hanjonh Ahn, Jae Y Ro, In Gab Jeong
PURPOSE: We compared the prognostic value of the American Joint Committee on Cancer (AJCC) TNM nodal staging system with that of lymph node (LN) density in patients with LN-positive bladder cancer who received extended or super-extended pelvic lymphadenectomy. METHODS: Of the 1,018 patients, who underwent radical cystectomy and pelvic lymphadenectomy between February 2005 and August 2014, 110 patients with LN metastases with extended (n = 68) or super-extended (n = 42) pelvic lymphadenectomy were included...
January 27, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28135678/curative-resection-for-locally-advanced-sigmoid-colon-cancer-using-neoadjuvant-chemotherapy-with-folfox-plus-panitumumab-a-case-report
#18
Kenji Tomizawa, Yuji Miura, Yudai Fukui, Yutaka Hanaoka, Shigeo Toda, Jin Moriyama, Naoko Inoshita, Yukinori Ozaki, Toshimi Takano, Shuichiro Matoba, Hiroya Kuroyanagi
INTRODUCTION: FOLFOX and panitumumab combined chemotherapy plays an important role for metastatic colorectal cancer. However the usefulness of this regimen for neoadjuvant therapy is unclear. CASE REPORT: A 67-year-old man with abdominal pain and pneumaturia was diagnosed with RAS wild-type sigmoid colon cancer with urinary bladder invasion and colovesical fistulas. Because the cancer was considered to be unresectable, a transverse-loop colostomy was performed. Colonoscopy and computed tomography revealed a marked reduction in the size of the primary tumor after six courses of FOLFOX4 (oxaliplatin, leucovorin, and 5-fluorouracil) plus panitumumab...
January 17, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28135623/molecular-biomarkers-to-predict-response-to-neoadjuvant-chemotherapy-for-bladder-cancer
#19
REVIEW
Consuelo Buttigliero, Marcello Tucci, Francesca Vignani, Giorgio V Scagliotti, Massimo Di Maio
Cystectomy is the gold standard for treatment of localized muscle-invasive bladder cancer. However, about 50% of patients develop metastases within 2years after cystectomy and subsequently die for the disease. Neoadjuvant cisplatin-based chemotherapy before cystectomy improves the overall survival in patients with muscle-invasive bladder cancer, and pathological response to neoadjuvant treatment (downstaging to ⩽pT1 at cystectomy) is a strong predictor of better disease-specific survival. Nevertheless, some patients do not benefit from neoadjuvant therapy...
January 11, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28133711/treatment-of-pelvic-floor-disorders-following-neobladder
#20
REVIEW
Nathan Littlejohn, Joshua A Cohn, Casey G Kowalik, Melissa R Kaufman, Roger R Dmochowski, W Stuart Reynolds
Radical cystectomy remains the gold standard treatment for organ-confined high-grade recurrent or muscle-invasive bladder cancer. Orthotopic neobladder urinary diversion following cystectomy represents an option for patients wishing for continent urinary diversion. Female patients who undergo radical cystectomy with orthotopic bladder substitution are at risk for developing both common and neobladder-specific disorders of the pelvic floor, including urinary incontinence, hypercontinence, vaginal prolapse, and neobladder-vaginal fistula...
January 2017: Current Urology Reports
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