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Bladder cancer, cystectomy

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https://www.readbyqxmd.com/read/29045422/cluster-analysis-identifies-three-urodynamic-patterns-in-patients-with-orthotopic-neobladder-reconstruction
#1
Kwang Hyun Kim, Hyun Suk Yoon, Wan Song, Hee Jung Choo, Hana Yoon, Woo Sik Chung, Bong Suk Sim, Dong Hyeon Lee
PURPOSE: To classify patients with orthotopic neobladder based on urodynamic parameters using cluster analysis and to characterize the voiding function of each group. MATERIALS AND METHODS: From January 2012 to November 2015, 142 patients with bladder cancer underwent radical cystectomy and Studer neobladder reconstruction at our institute. Of the 142 patients, 103 with complete urodynamic data and information on urinary functional outcomes were included in this study...
2017: PloS One
https://www.readbyqxmd.com/read/29043112/tumor-infiltrating-cd8-lymphocytes-predict-different-clinical-outcomes-in-organ-and-non-organ-confined-urothelial-carcinoma-of-the-bladder-following-radical-cystectomy
#2
Shiqiang Zhang, Jun Wang, Xinyu Zhang, Fangjian Zhou
Tumor-infiltrating lymphocytes (TILs) are associated with better clinical outcomes in many tumors. TILs represent a cell-mediated immune response against the carcinoma. CD8+ TILs are a crucial component of cell-mediated immunity. The significance of CD8+ TILs has not been reported respectively in organ- and non-organ-confined urothelial carcinoma (UC) of the bladder. We explored the prognostic value of CD8+ TILs in the two groups. The presence of CD8+ TILs was assessed by immunohistochemical staining of whole tissue sections from 75 organ and 51 non-organ-confined disease patients with long-term follow-up, and its correlation with clinicopathological features and overall survival (OS) was determined...
2017: PeerJ
https://www.readbyqxmd.com/read/29032239/outcomes-following-clinical-complete-response-to-neoadjuvant-chemotherapy-for-muscle-invasive-urothelial-carcinoma-of-the-bladder-in-patients-refusing-radical-cystectomy
#3
Dennis Robins, Justin Matulay, Michael Lipsky, Alexa Meyer, Rashed Ghandour, Guarionex DeCastro, Christopher Anderson, Charles Drake, Mitchell Benson, James McKiernan
OBJECTIVE: To investigate survival outcomes of patients with muscle-invasive bladder cancer (MIBC) that demonstrate complete clinical response (cT0) to neoadjuvant chemotherapy (NAC) and then reject subsequent radical cystectomy (RC). MATERIALS AND METHODS: A retrospective chart review identified MIBC patients who were cT0 after platinum-based NAC. CT0 was defined as negative cytology, cystoscopy with transurethral resection of bladder tumor (TURBT), and imaging...
October 12, 2017: Urology
https://www.readbyqxmd.com/read/29030318/the-association-between-mortality-and-distance-to-treatment-facility-in-patients-with-muscle-invasive-bladder-cancer
#4
Stephen Ryan, Emily C Serrell, Patrick Karabon, Gregory Mills, Moritz Hansen, Matthew Hayn, Mani Menon, Quoc-Dien Trinh, Firas Abdollah, Jesse D Sammon
PURPOSE: Regionalization of bladder cancer treatment is suggested to improve quality of care. As an unintended consequence, some patients travel farther for care with unknown implications on outcomes. We characterize the relationship between distance and overall mortality in patients with invasive bladder cancer and those who undergo radical cystectomy. METHODS: We performed a retrospective cohort study using the National Cancer Database (2004-2012) to identify patients with muscle invasive bladder cancer (cT2a-T4 N0 M0); a sub-group of radical cystectomy patients was extracted...
October 10, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29029448/risk-stratified-surveillance-and-cost-effectiveness-of-follow-up-after-radical-cystectomy-in-patients-with-muscle-invasive-bladder-cancer
#5
Ayumu Kusaka, Shingo Hatakeyama, Shogo Hosogoe, Itsuto Hamano, Hiromichi Iwamura, Naoki Fujita, Ken Fukushi, Takuma Narita, Kazuhisa Hagiwara, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Hiroyuki Ito, Kazuaki Yoshikawa, Toshiaki Kawaguchi, Chikara Ohyama
BACKGROUND: The recurrence risk stratification and the cost effectiveness of oncological surveillance after radical cystectomy are not clear. We aimed to develop a risk stratification and a surveillance protocol with improved cost effectiveness after radical cystectomy. RESULTS: Of 581 enrolled patients, 175 experienced disease recurrences. The pathology-based protocol presented significant differences in recurrence-free survival between normal- and high-risk patients, but the medical expense was high, especially in normal-risk (≤pT2pN0) patients...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29027351/robotic-assisted-versus-open-radical-cystectomy-in-bladder-cancer-a-meta-analysis-of-four-randomized-controlled-trails
#6
Jin-Qiu Tang, Zhihong Zhao, Yiwen Liang, Guixiang Liao
BACKGROUND: Robot-assisted radical cystectomy (RARC) is increasing annually for treatment of bladder cancer. The objective of this meta-analysis was to compare the safety and efficacy of RARC and open radical cystectomy (ORC) for bladder cancer. METHODS: Our meta-analysis searches were conducted using PubMed, Web of Science, and Cochrane Library databases to identify randomized controlled trials (RCT) assessing the two techniques. RESULTS: Four RCT studies were identified, including 239 cases...
October 12, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/29023722/prevalence-and-clonality-of-synchronous-primary-carcinomas-in-the-bladder-and-prostate
#7
Ying Jing, Ruiyun Zhang, Pengfei Ma, Mei-Chun Cai, Guanglei Zhuang, Haige Chen
Incidental prostate adenocarcinoma (IPCa) has been frequently discovered during postoperative histopathological evaluation of radical cystoprostatectomy specimens in patients with bladder cancer (BCa). However, there is currently no conclusive study addressing the clinical significance of IPCa and the clonal relatedness of IPCa and BCa. Here, we performed a retrospective single-center review of 919 BCa cases and an additional meta-analysis including a total of 19,868 individuals who underwent radical cystectomy for bladder cancer...
October 11, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28994883/long-term-outcome-of-intravesical-bacillus-calmette-gu%C3%A3-rin-therapy-with-maintenance-for-urinary-bladder-carcinoma-in-situ-about-47-cases
#8
Sataa Sallami, Hassen Khouni, Mahmoud Ben Atta, Sana Abou El Makarim, Mohamed Bechir Zouari, Sami Ben Rhouma
INTRODUCTION: Data concerning the efficacy of intravesical Bacillus Calmette-Guerin (BCG) on carcinoma in situ (CIS) of the bladder are limited. OBJECTIVES: We analyzed long-term outcomes of instillation therapy with BCG to treat bladder CIS, evaluated its effectiveness and safety and searched for prognostic factors that could predict disease recurrence and progression. METHODS: Between March 1994 and December 2010, 47 patients (male: 40; female: 7) with median age of 59,5 years (range 40-76 years), diagnosed with bladder CIS underwent weekly BCG instillations (75 mg of Pasteur strain) for six weeks followed by 6 monthly instillations...
December 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28982896/abo-blood-group-and-rhesus-factor-are-not-associated-with-outcomes-after-radical-cystectomy-for-non-metastatic-urothelial-carcinoma-of-the-bladder
#9
David D'Andrea, Marco Moschini, Francesco Soria, Kilian M Gust, Alberto Briganti, Pierre I Karakiewicz, Morgan Rouprêt, Shahrokh F Shariat
AIM: To investigate the role of ABO blood group and Rhesus factor as a predictor of outcome in patients undergoing radical cystectomy (RC) for non-metastatic urothelial carcinoma of the bladder. MATERIALS AND METHODS: Data of 463 consecutive patients treated with RC between 1988 and 2003 were retrospectively analyzed. The effect on recurrence-free survival, and cancer-specific and overall mortality were assessed using the Kaplan-Meier and multivariable Cox regression methods...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28982876/radical-cystectomy-versus-chemoradiation-for-muscle-invasive-bladder-cancer-impact-of-treatment-facility-and-sociodemographics
#10
COMPARATIVE STUDY
Waqar Haque, Vivek Verma, E Brian Butler, Bin S Teh
BACKGROUND: The present study sought to compare the differences in practice patterns, as well as clinical outcomes for patients with muscle-invasive bladder cancer undergoing treatment with either radical cystectomy (RC) or concurrent chemoradiaiton (CRT). PATIENTS AND METHODS: The National Cancer Data Base (NCDB) was queried for patients diagnosed with T2/T3/T4aN0M0 bladder cancer, between 2004-2013, that received definitive treatment with either RC or CRT. RESULTS: 16,960 patients met the inclusion criteria; 1,450 (8...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28982751/clinical-significance-of-histologic-variants-of-bladder-cancer
#11
REVIEW
Joshua I Warrick
Pathologists have identified many "histologic variants" of bladder cancer (BCA): histologic patterns that differ from conventional urothelial carcinoma (transitional cell carcinoma). Several of these are biologically aggressive, and their identification may aid in clinical decision-making. This article reviews several histologic variants and their value in deciding management of cT1 disease and predicting response to neoadjuvant chemotherapy (NAC). Diagnostic issues are also addressed, such as interobserver variability among pathologists...
October 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28978923/immunological-tumor-status-may-predict-response-to-neoadjuvant-chemotherapy-and-outcome-after-radical-cystectomy-in-bladder-cancer
#12
Minna Tervahartiala, Pekka Taimen, Tuomas Mirtti, Ilmari Koskinen, Thorsten Ecke, Sirpa Jalkanen, Peter J Boström
Bladder cancer (BC) is the ninth most common cancer worldwide. Radical cystectomy (RC) with neoadjuvant chemotherapy (NAC) is recommended for muscle-invasive BC. The challenge of the neoadjuvant approach relates to challenges in selection of patients to chemotherapy that are likely to respond to the treatment. To date, there are no validated molecular markers or baseline clinical characteristics to identify these patients. Different inflammatory markers, including tumor associated macrophages with their plastic pro-tumorigenic and anti-tumorigenic functions, have extensively been under interests as potential prognostic and predictive biomarkers in different cancer types...
October 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28978174/comparison-of-outcomes-between-trimodal-therapy-and-radical-cystectomy-in-muscle-invasive-bladder-cancer-a-propensity-score-matching-analysis
#13
Yeon Joo Kim, Sang Jun Byun, Hanjong Ahn, Choung-Soo Kim, Beom-Sik Hong, Sangjun Yoo, Jae-Lyun Lee, Young Seok Kim
Although radical cystectomy (RC) is considered as the standard therapy for muscle-invasive bladder cancer (MIBC), trimodal therapy (TMT) combining transurethral resection of the tumor with radiotherapy and chemotherapy is increasingly recommended as an alternative approach for bladder preservation. In the absence of randomized trials, we compared the clinical outcomes between RC and TMT using propensity score matching with 50 patients in the RC arm and 29 patients in the TMT arm. With respective median follow-up periods of 23 and 32 months for the RC and TMT groups, 5-year distant metastasis-free survival (58% vs...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28978000/pd-l1-expression-in-bladder-cancer-and-metastasis-and-its-influence-on-oncologic-outcome-after-cystectomy
#14
Renate Pichler, Isabel Heidegger, Josef Fritz, Melanie Danzl, Susanne Sprung, Bettina Zelger, Andrea Brunner, Andreas Pircher
Platinum-based chemotherapy is the standard of care in metastatic bladder cancer. With the approval of various checkpoint inhibitors, immunotherapy has revolutionized the traditional treatment modalities. The aim of the study was to evaluate whether PD-L1 expression on tumor cells (TCs) and tumor-infiltrating immune cells (ICs) can be used as biomarker to predict recurrence-free survival (RFS), overall survival (OS) and disease-specific survival (DSS) in bladder cancer patients after radical cystectomy (RC) developing disease recurrence followed by first-line chemotherapy...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28977873/preoperative-chronic-kidney-disease-predicts-poor-oncological-outcomes-after-radical-cystectomy-in-patients-with-muscle-invasive-bladder-cancer
#15
Itsuto Hamano, Shingo Hatakeyama, Hiromichi Iwamurau, Naoki Fujita, Ken Fukushi, Takuma Narita, Kazuhisa Hagiwara, Ayumu Kusaka, Shogo Hosogoe, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Hiroyuki Ito, Kazuaki Yoshikawa, Toshiaki Kawaguchi, Chikara Ohyama
OBJECTIVE: To evaluate the impact of preoperative chronic kidney disease (CKD) on oncologic outcomes in muscle-invasive bladder cancer patients who underwent radical cystectomy. METHODS: A total of 581 patients who underwent radical cystectomy at four medical centers between January 1995 and February 2017 were examined retrospectively. We investigated oncologic outcomes, including progression-free, cancer-specific, and overall survival (PFS, CSS, and OS, respectively) stratified by preoperative CKD status (pre-CKD vs...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28974310/bladder-sparing-radiotherapy-for-muscle-invasive-bladder-cancer-a-survey-of-providers-to-determine-barriers-and-enablers
#16
Melanie Walker, Simon D French, R Christopher Doiron, Kelly Brennan, Deb Feldman-Stewart, D Robert Siemens, William J Mackillop, Christopher M Booth
BACKGROUND: To understand barriers and enablers to use of curative-intent radiotherapy (RT) for muscle-invasive bladder cancer using the Theoretical Domains Framework (TDF). METHODS: Canadian urologists, radiation oncologists (ROs) and medical oncologists (MOs) participated in a web-based survey to assess barriers and enablers to use of RT. Survey questions were thematically mapped to TDF domains. Logistic regression was used to identify TDF domains associated with high referral/use of RT...
September 30, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28971439/quality-of-life-in-elderly-bladder-cancer-patients-following-a-cystectomy
#17
Maria Lavdaniti, Sofia Zyga
INTRODUCTION: Bladder cancer is the ninth most common cancer worldwide. The most common treatment for invasive cancer is radical cystectomy and urinary diversion (ileal conduit, continent urinary reservoir, orthotopic neobladder). In elderly patients, the standards methods of urinary diversion have been the ileal conduit and ureterocutaneostomy. Quality of life is an important consideration for patients with urinary diversion. PURPOSE: The purpose of the present study was to review the literature on quality of life in elderly patients with bladder cancer following a cystectomy and urinary diversion...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28967556/re-low-pretreatment-neutrophil-to-lymphocyte-ratio-predicts-for-good-outcomes-in-patients-receiving-neoadjuvant-chemotherapy-before-radical-cystectomy-for-muscle-invasive-bladder-cancer
#18
https://www.readbyqxmd.com/read/28967303/laparoendoscopic-single-site-radical-cystectomy-versus-conventional-laparoscopic-radical-cystectomy-for-patient-with-bladder-urothelial-carcinoma-matched-case-control-analysis
#19
Xu Zhang, Kai Xu, Bin Lang, Bin Fu, Taoping Shi, Baojun Wang
OBJECTIVE: Laparoendoscopic single-site surgery (LESS) is increasingly popular in urology. However, data on LESS radical cystectomy (LESS-RC) are immature, and no adequate comparative study has assessed conventional laparoscopic radical cystectomy (CL-RC) versus LESS-RC. The primary aim of this study was to compare efficiency and safety of LESS-RC and CL-RC for patients with bladder urothelial carcinoma (BUC). MATERIALS AND METHODS: A retrospective and case-matched control comparative analysis was performed of patients who underwent LESS-RC (n= 54) and CL-RC (n= 108) from January 2011 to June 2015...
October 1, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28963292/cohort-profile-the-swedish-national-register-of-urinary-bladder-cancer-snrubc-and-the-bladder-cancer-data-base-sweden-bladderbase
#20
Christel Häggström, Fredrik Liedberg, Oskar Hagberg, Firas Aljabery, Viveka Ströck, Abolfazl Hosseini, Truls Gårdmark, Amir Sherif, Per-Uno Malmström, Hans Garmo, Staffan Jahnson, Lars Holmberg
PURPOSE: To monitor the quality of bladder cancer care, the Swedish National Register of Urinary Bladder Cancer (SNRUBC) was initiated in 1997. During 2015, in order to study trends in incidence, effects of treatment and survival of men and women with bladder cancer, we linked the SNRUBC to other national healthcare and demographic registers and constructed the Bladder Cancer Data Base Sweden (BladderBaSe). PARTICIPANTS: The SNRUBC is a nationwide register with detailed information on 97% of bladder cancer cases in Sweden as compared with the Swedish Cancer Register...
September 27, 2017: BMJ Open
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