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Bladder cancer, cystectomy

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https://www.readbyqxmd.com/read/29219283/comparative-differences-between-t1a-b-and-t1e-m-as-substages-in-t1-urothelial-carcinoma-of-the-bladder
#1
Turgay Turan, Özgür Efiloğlu, Bilal Günaydin, Şeyma Özkanli, Emrah Nikerel, Gökhan Atiş, Turhan Çaşkurlu, Asif Yildirim
OBJECTIVE: To evaluate the prognostic value of the depth of lamina propria invasion in patients with T1 bladder cancer and to display comparative differences between the T1a/b and T1e/m substaging systems. PATIENTS AND METHODS: This study included 106 patients with primary stage T1 urothelial bladder tumours who underwent surgery between January 2009 and December 2014. Pathologic specimens were re-evaluated to confirm the diagnosis of T1 and substaging by the same pathologist using two systems: T1a and T1b, and T1m and T1e...
December 11, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29219280/transperitoneal-vs-extraperitoneal-radical-cystectomy-for-bladder-cancer-a-retrospective-study
#2
Jagdeesh N Kulkarni, Himanshu Agarwal
PURPOSE: Conventional transperitoneal radical cystectomy (TPRC) is the standard approach for muscle invasive bladder cancer. But, the procedure is associated with significant morbidities like urinary leak, ileus, and infection. To reduce these morbidities, the technique of extraperitoneal radical cystectomy (EPRC) was described by us in 1999. We compared these two approaches and the data accrued forms the basis of this report. MATERIALS AND METHODS: All patients who underwent radical cystectomy for bladder cancer by the author (JNK) with follow-up for at least 5 years were included...
December 11, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29212084/perioperative-outcomes-and-early-survival-in-octogenarians-who-underwent-radical-cystectomy-for-bladder-cancer
#3
Fabio Zattoni, Vito Palumbo, Gianluca Giannarini, Alessandro Crestani, Afrovita Kungulli, Giacomo Novara, Filiberto Zattoni, Vincenzo Ficarra
OBJECTIVE: To evaluate perioperative outcomes and early survival in a series of octogenarians who underwent radical cystectomy (RC) and urinary diversion for bladder cancer. PATIENTS AND METHODS: We retrospectively evaluated the clinical records of 44 patients aged ≥80 years who underwent open RC and urinary diversion at 2 high-volume centers between July 2013 and December 2015. Estimated blood loss (EBL), transfusion rate, and length of hospital stay (LOS) were evaluated...
December 7, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/29211394/ureteroileal-bypass-a-new-technic-to-treat-ureteroenteric-strictures-in-urinary-diversion
#4
Guilherme P Padovani, Marcos F Mello, Rafael F Coelho, Leonardo L Borges, Adriano Nesrallah, Miguel Srougi, William C Nahas
OBJECTIVE: To present our technique of ureteroileal bypass to treat uretero-enteric strictures in urinary diversion. MATERIALS AND METHODS: One hundred and forty-one medical records were reviewed from patients submitted to radical cystectomy to treat muscle-invasive bladder cancer between 2013 and 2015. Twelve (8.5%) patients developed uretero-enteric anastomotic stricture during follow-up. Five patients were treated with endoscopic dilatation and double J placement...
December 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29196070/evaluation-of-urinary-dna-methylation-as-a-marker-for-recurrent-bladder-cancer-a-two-center-prospective-study
#5
Tetsuya Shindo, Takashi Shimizu, Masanori Nojima, Takeshi Niinuma, Reo Maruyama, Hiroshi Kitajima, Masahiro Kai, Naoki Itoh, Hiromu Suzuki, Naoya Masumori
OBJECTIVE: To clarify the clinical utility of urinary DNA methylation for detection of intravesical recurrence of non-muscle invasive BCa (NMIBC), we performed a 2 center prospective study. PATIENTS AND METHODS: A series of 207 self-voided urine samples were prospectively collected from 132 NMIBC patients who had undergone transurethral resection of BCa. Methylation of miRNA genes (miR-9-3, miR-124-2, miR-124-3 and miR-137) was analyzed using bisulfite pyrosequencing...
November 28, 2017: Urology
https://www.readbyqxmd.com/read/29188298/adjuvant-sandwich-chemotherapy-plus-radiotherapy-vs-adjuvant-chemotherapy-alone-for-locally-advanced-bladder-cancer-after-radical-cystectomy-a-randomized-phase-2-trial
#6
Mohamed S Zaghloul, John P Christodouleas, Andrew Smith, Ahmed Abdallah, Hany William, Hussein M Khaled, Wei-Ting Hwang, Brian C Baumann
Importance: Locoregional failure for patients with locally advanced bladder cancer (LABC) after radical cystectomy (RC) is common even with chemotherapy and is associated with high morbidity and mortality. Adjuvant radiotherapy (RT) can decrease locoregional failure but has not been studied in the chemotherapy era. Objective: To investigate if adjuvant sequential RT plus chemotherapy can improve locoregional recurrence-free survival (LRFS) compared with adjuvant chemotherapy alone...
November 29, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29188276/a-potential-role-for-adjuvant-chemotherapy-and-radiotherapy-for-patients-with-high-risk-bladder-cancer-treated-with-cystectomy-in-the-united-states
#7
Dayssy A Diaz, Amir Mortazavi, Cheryl T Lee
No abstract text is available yet for this article.
November 29, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29185631/-myths-and-reality-about-immunonutrition-in-uro-oncology
#8
Yannick Cerantola
Postoperative morbidity remains a nightmare (although vivid), both for the patient and the surgeon. One phantasmagorical idea would be to give the patient a « magic potion » preoperatively aiming at eliminating the risk of postoperative complication. The purpose of the present review is to summarize the current knowledge on the potential benefits of immunonutrition administered to urological cancers patients. After a brief summary on the role of immunity in cancer surveillance and treatment, the rationale about administrating oral nutritional supplements able to modulate the patient's immune system before cystectomy for bladder cancer will be highlighted...
November 29, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29185045/preoperative-chronic-kidney-disease-is-predictive-of-oncological-outcome-of-radical-cystectomy-for-bladder-cancer
#9
Akihiko Matsumoto, Tohru Nakagawa, Atsushi Kanatani, Masaomi Ikeda, Taketo Kawai, Jimpei Miyakawa, Satoru Taguchi, Akihiro Naito, Masafumi Otsuka, Yasukazu Nakanishi, Motofumi Suzuki, Fumitaka Koga, Yasushi Nagase, Yasushi Kondo, Toshikazu Okaneya, Yoshinori Tanaka, Hideyo Miyazaki, Tetsuya Fujimura, Hiroshi Fukuhara, Haruki Kume, Yasuhiko Igawa, Yukio Homma
PURPOSE: To evaluate the impact of preoperative chronic kidney disease (CKD) on oncological outcomes after radical cystectomy (RC) for bladder cancer. METHODS: We reviewed the medical records of patients with urothelial bladder carcinoma who underwent RC with curative intent at seven hospitals between 1990 and 2013. After excluding patients with a history of upper urinary tract urothelial cancer or neoadjuvant chemotherapy, we analyzed 594 cases for the study. Preoperative estimated glomerular filtration rate (eGFR) was calculated using the three-variable Japanese equation for GFR estimation from serum creatinine level and age...
November 28, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29181804/vigorous-intensity-aerobic-interval-exercise-in-bladder-cancer-patients-prior-to-radical-cystectomy-a-feasibility-randomised-controlled-trial
#10
Srijit Banerjee, Kate Manley, Barnabas Shaw, Liane Lewis, Gabriel Cucato, Robert Mills, Mark Rochester, Allan Clark, John M Saxton
PURPOSE: Strategies to improve pre-operative cardiopulmonary fitness could positively impact recovery after surgery. This study investigated the feasibility of vigorous intensity aerobic interval exercise in bladder cancer patients prior to radical cystectomy (RC). METHODS: A total of 60 patients were randomised (1:1) to exercise or control following a cardiopulmonary exercise test (CPET). The exercise group was offered twice-weekly pre-operative supervised vigorous intensity aerobic interval exercise in addition to standard treatment...
November 27, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29180897/prognostic-value-of-site-specific-metastases-and-therapeutic-roles-of-surgery-for-patients-with-metastatic-bladder-cancer-a-population-based-study
#11
Fan Dong, Yifan Shen, Fengbin Gao, Tianyuan Xu, Xianjin Wang, Xiaohua Zhang, Shan Zhong, Minguang Zhang, Shanwen Chen, Zhoujun Shen
Background: We aimed to evaluate the prognostic value of site-specific metastases in patients with metastatic bladder cancer and analyze the roles that surgeries play in the treatment of this malignancy. Materials and methods: A population-based retrospective study using Surveillance, Epidemiology and End Results dataset was performed and metastatic bladder cancer patients were classified according to the sites of metastases (bone, brain, liver, lung and distant lymph nodes)...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/29179475/genetic-variants-in-the-inflammation-pathway-as-predictors-of-recurrence-and-progression-in-non-muscle-invasive-bladder-cancer-treated-with-bacillus-calmette-gu%C3%A3-rin
#12
Stephen B Williams, Ashish M Kamat, Chinedu Mmeje, Yuanquing Ye, Maosheng Huang, David W Chang, Colin P Dinney, Xifeng Wu
Inflammation plays a critical role in the etiology of several cancers and may affect their clinical outcome. Our objective was to assess the association of genetic variants within the inflammation pathway with recurrence and progression among non-muscle invasive bladder cancer (NMIBC) patients with or without Bacillus Calmette-Guérin (BCG) treatment. We genotyped 372 single nucleotide polymorphisms (SNPs) in 27 selected genes within the inflammation pathway in 349 patients diagnosed with NMIBC, followed by internal validation in 322 additional patients...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29178899/smoking-and-alcohol-cessation-intervention-in-relation-to-radical-cystectomy-a-qualitative-study-of-cancer-patients-experiences
#13
Susanne Vahr Lauridsen, Thordis Thomsen, Gudrun Kaldan, Line Noes Lydom, Hanne Tønnesen
BACKGROUND: Despite smoking and risky alcohol drinking being modifiable risk factors for cancer as well as postoperative complications, perioperative cessation counselling is often ignored. Little is known about how cancer patients experience smoking and alcohol interventions in relation to surgery. Therefore the aim of this study was to explore how bladder cancer patients experience a perioperative smoking and alcohol cessation intervention in relation to radical cystectomy. METHODS: A qualitative study was conducted in two urology out-patient clinics...
November 25, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29171098/can-bladder-preservation-therapy-come-to-the-center-stage
#14
REVIEW
Teruo Inamoto, Naokazu Ibuki, Kazumasa Komura, Hiroshi Juri, Kiyohito Yamamoto, Kazuhiro Yamamoto, Kazutoshi Fujita, Norio Nonomura, Yoshifumi Narumi, Haruhito Azuma
Decision-making in urological cancer care requires a multidisciplinary approach for refinement, but its impact on urothelial carcinoma of the bladder has not been fully addressed for the past three decades, except for the latest immunological checkpoint inhibitor approved by the U.S. Food and Drug Administration for metastatic muscle-invasive bladder cancer that is resistant to platinum-based chemotherapy. For the time being, radical cystectomy is the gold standard of curative therapy for muscle-invasive bladder cancer...
November 23, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29169845/impact-of-adequate-pelvic-lymph-node-dissection-on-overall-survival-after-radical-cystectomy-a-stratified-analysis-by-clinical-stage-and-receipt-of-neoadjuvant-chemotherapy
#15
Nicolas von Landenberg, Jacqueline M Speed, Alexander P Cole, Thomas Seisen, Stuart R Lipsitz, Philipp Gild, Mani Menon, Adam S Kibel, Florian Roghmann, Joachim Noldus, Maxine Sun, Quoc-Dien Trinh
PURPOSE: An adequate pelvic lymph node dissection (LND) during radical cystectomy (RC) for muscle-invasive bladder cancer (BCa) has been shown to provide a survival benefit. We designed a study to assess the effect of adequate LND on overall survival (OS) according to cT stage and receipt of neoadjuvant chemotherapy (NAC). MATERIAL AND METHODS: We identified 16,505 patients with localized BCa who received RC in the National Cancer Database (2004-2012). Inverse probability of treatment weighting (IPTW)-adjusted Kaplan-Meier and Cox regression analyses were used to compare OS between patients who received adequate LND (defined as ≥10 nodes removed) and those who did not, stratified by cT stage and receipt of NAC...
November 20, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29169450/orthotopic-urinary-diversion-for-women
#16
REVIEW
Dimitar V Zlatev, Eila C Skinner
Orthotopic neobladder is a viable option for women undergoing cystectomy for bladder cancer, with excellent oncologic outcomes and a low incidence of urethral recurrence. Careful patient selection is important, as is developing a clear understanding by the patient and her family in what to expect with an orthotopic diversion. Surgical technique is also important in optimizing functional outcomes, such as continence, sexual function, and decreased rate of vaginal fistula formation, and urinary retention.
February 2018: Urologic Clinics of North America
https://www.readbyqxmd.com/read/29167985/short-term-outcome-after-cystectomy-comparison-of-early-oral-feeding-in-an-enhanced-recovery-protocol-and-feeding-using-bengmark-nasojejunal-tube
#17
C S Voskuilen, E E Fransen van de Putte, J Bloos-van der Hulst, E van Werkhoven, W M de Blok, B W G van Rhijn, S Horenblas, R P Meijer
PURPOSE: Cystectomy for bladder cancer is associated with a high risk of postoperative complications. Standardized perioperative protocols, such as enhanced recovery after surgery (ERAS) protocols, aim to improve postoperative outcome. Postoperative feeding strategies are an important part of these protocols. In this two-centre study, we compared complications and length of hospital stay (LOS) between an ERAS protocol with early oral nutrition and a protocol with early enteral feeding with a Bengmark nasojejunal tube...
November 22, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29162314/clinical-characteristics-and-outcomes-of-nonurothelial-cell-carcinoma-of-the-bladder-results-from-the-national-cancer-data-base
#18
Trevor J Royce, Chun C Lin, Phillip J Gray, William U Shipley, Ahmedin Jemal, Jason A Efstathiou
OBJECTIVES: To determine the clinical characteristics, treatment patterns, and outcomes of patients with nonurothelial cell bladder cancer (NUBC) in the United States. METHODS: A total of 163,683 patients with bladder cancer from 1998 to 2014 in the National Cancer Data Base were identified. Of all, 153,262 had urothelial cell (UC) carcinoma (93.6%) and 10,421 had NUBC (6.4%) further classified as: squamous cell carcinoma (SC, 2.4%), adenocarcinoma (AC, 1.7%), neuroendocrine (NE, 1...
November 18, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29156782/trends-in-neoadjuvant-chemotherapy-use-and-oncological-outcomes-for-muscle-invasive-bladder-cancer-in-japan-a-multicenter-study
#19
Go Anan, Shingo Hatakeyama, Naoki Fujita, Hiromichi Iwamura, Toshikazu Tanaka, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Hiroyuki Ito, Kazuaki Yoshikawa, Toshiaki Kawaguchi, Makoto Sato, Chikara Ohyama
Objective: Despite benefits of neoadjuvant chemotherapy (NAC), the adoption of guideline recommendations for NAC use in patients with muscle-invasive bladder cancer (MIBC) has been slow. We aimed to evaluate temporal trends in NAC use and oncological outcomes in a representative cohort of patients with MIBC. Methods: We included 532 patients from 4 hospitals who underwent radical cystectomy (RC) for ≥ cT2 MIBC in 1996-2017. We retrospectively evaluated temporal changes in NAC use and progression-free and overall survival...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29154041/patient-characteristics-treatment-patterns-and-prognostic-factors-in-squamous-cell-bladder-cancer
#20
Haris Zahoor, Paul Elson, Andrew Stephenson, Georges-Pascal Haber, Jihad Kaouk, Amr Fergany, Byron Lee, Vadim Koshkin, Moshe Ornstein, Timothy Gilligan, Jorge A Garcia, Brian Rini, Petros Grivas
BACKGROUND: Squamous cell carcinoma (SCC) is an uncommon histologic subtype of bladder cancer with limited data on treatment patterns, outcomes, and prognostic factors. "Real world" information might inform decision-making, prognostic estimates, and clinical trial designs. PATIENTS AND METHODS: A retrospective review of patients with tissue-confirmed bladder SCC treated at Cleveland Clinic from 2007 to 2016 was performed. Data on patient characteristics, treatment patterns, and clinical follow-up were extracted...
October 17, 2017: Clinical Genitourinary Cancer
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