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https://www.readbyqxmd.com/read/29747367/-ultrastructure-of-the-lens-anterior-capsule-in-secondary-cataract-associated-with-uveitis-under-an-electron-microscope
#1
M L Yang, L Yang
Objective: To observe the ultrastructure of lens epithelium cells in cataract associated with uveitis. Methods: A cross-sectional study. Seven patients(7 eyes) received phacoemulsification in Peking University First Hospital from August 2016 to March 2017 due to complicated cataract associated with uveitis[2 males and 5 females,with an average age of (49±20) years] and 3 patients of age-related cataract (3 eyes, females, aged 54, 71, 74 years) were enrolled. Anterior capsule samples were collected during surgery...
May 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29705099/ultraviolet-radiation-exposure-triggers-neurokinin-1-receptor-upregulation-in-ocular-tissues-in-vivo
#2
Janine Gross, Alfred R Wegener, Martin Kronschlaeger, Frank G Holz, Carl-Ludwig Schönfeld, Linda M Meyer
The purpose of this study was to investigate the neurokinin receptor-1 (NKR-1) protein expression in ocular tissues before and after supra-cataract threshold ultraviolet radiation (UVR-B peak at 312 nm) exposure in vivo in a mouse model. Six-week-old C57Bl/6 mice were unilaterally exposed to a single (2.9 kJ/m2 ) and an above 3-fold UVR-B cataract threshold dose (9.4 kJ/m2 ) of UVR. UVR-exposure (λpeak = 312 nm) was performed in mydriasis using a Bio-Spectra exposure system. After latency periods of 3 and 7 days, eyes were fixed in 4% paraformaldehyde, embedded in paraffin, sectioned and stained with fluorescence coupled antibody for NKR-1 and DAPI for cell nuclei staining...
April 26, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29626052/association-between-serum-lipids-concentration-and-patients-with-age-related-cataract-in-china-a-cross-sectional-case-control-study
#3
Shengjie Li, Danhui Li, Yudong Zhang, Jisen Teng, Mingxi Shao, Wenjun Cao
OBJECTIVE: Obesity and a high-fat diet have been found to be associated with an increased risk of age-related cataract (ARC). Thus, this study aimed to investigate whether serum lipid levels are associated with the incidence of ARC. DESIGN: Cross-sectional, case-control study. SETTING: EyeandENT Hospital of Fudan University, Shanghai, China. PARTICIPANTS: A total of 219 ARC (male=94, female=125) subjects and 218 (male=110, female=118) normal control subjects were recruited in this study...
April 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29604281/deletion-of-glut1-in-mouse-lens-epithelium-leads-to-cataract-formation
#4
Aditi Swarup, Brent A Bell, Jianhai Du, John Y S Han, Jamie Soto, E Dale Abel, Arturo Bravo-Nuevo, Paul G FitzGerald, Neal S Peachey, Nancy J Philp
The primary energy substrate of the lens is glucose and uptake of glucose from the aqueous humor is dependent on glucose transporters. GLUT1, the facilitated glucose transporter encoded by Slc2a1 is expressed in the epithelium of bovine, human and rat lenses. In the current study, we examined the expression of GLUT1 in the mouse lens and determined its role in maintaining lens transparency by studying effects of postnatal deletion of Slc2a1. In situ hybridization and immunofluorescence labeling were used to determine the expression and subcellular distribution of GLUT1 in the lens...
March 28, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29587970/association-between-cataract-progression-and-ischemia-modified-albumin-in-relation-to-oxidant-antioxidant-profiles-in-the-serum-aqueous-humor-and-lens
#5
Hesham M Elmazar, Ibrahim Elmadbouh, Sameh S Mandour, Gehad M Al Ariny, Asmaa M Ibrahim
PURPOSE: To evaluate the levels of ischemia-modified albumin (IMA) in relation to oxidant-antioxidant profiles in the serum, aqueous, and lens in cataract patients. SETTING: Department of Ophthalmology, Menoufia University, Shebin El Kom, Menoufia, Egypt. DESIGN: Prospective case series. METHODS: Patients were divided into 2 groups. The cataract (study) group comprised patients with senile cataract and the control group, age- and sex-matched healthy persons...
February 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29535500/flicker-electroretinograms-of-eyes-with-cataract-recorded-with-reteval-system-before-and-after-mydriasis
#6
Gen Miura, Takayuki Baba, Toshiyuki Oshitari, Shuichi Yamamoto
Purpose: The aim of this study is to determine the effect of pupil size of eyes with cataracts on the flicker electroretinograms (ERGs) elicited and recorded with the RETeval system. Patients and methods: Forty-one eyes of 41 patients (mean age, 76.5±7.3 years) that had grade 2 nuclear or cortical cataract without any other abnormalities were studied. Flicker ERGs were recorded before and after mydriatic drops instillation. The ERGs were elicited by the white light delivered at the frequency of 28...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29523441/visual-and-refractive-outcomes-in-manual-versus-femtosecond-laser-assisted-cataract-surgery-a-single-center-retrospective-cohort-analysis-of-1838-eyes
#7
Thomas A Berk, Matthew B Schlenker, Xavier Campos-Möller, Austin M Pereira, Iqbal Ike K Ahmed
PURPOSE: Femtosecond laser-assisted cataract surgery (FLACS) has emerged as an alternative to manual cataract surgery (MCS) for corneal incision and capsulorhexis creation, as well as nuclear fragmentation. This study compares postoperative refractive and visual outcomes in eyes receiving MCS or FLACS. DESIGN: Single-center, comparative, retrospective cohort analysis. PARTICIPANTS: Consecutive eyes receiving FLACS and MCS from July 1, 2012, to July 31, 2015, at a single tertiary care center...
March 6, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29498015/enhanced-penetration-for-axial-length-measurement-of-eyes-with-dense-cataracts-using-swept-source-optical-coherence-tomography-a-consecutive-observational-study
#8
Nino Hirnschall, Ralph Varsits, Birgit Doeller, Oliver Findl
INTRODUCTION: The aim of this study was to find cases in which the axial eye length could not be measured with partial coherence interferometry (PCI) technology and to assess if it could be measured using swept source optical coherence tomography (ss-OCT) technology. METHODS: All patients were measured at their pre-assessment visit 1 week prior to cataract surgery using conventional optical biometry (PCI technology, IOLMaster 500, Carl Zeiss Meditec AG, Jena, Germany)...
March 1, 2018: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29468207/bull-s-eye-maculopathy-and-subfoveal-deposition-in-two-mucopolysaccharidosis-type-i-patients-on-long-term-enzyme-replacement-therapy
#9
Heather G Mack, R C Andrew Symons, Gerard de Jong
Purpose: To report retinal findings in two patients with mucopolysaccharidosis type I (MPS I) receiving human recombinant alpha-l-iduronidase (Laronidase) as enzyme replacement therapy. Observations: Patient 1 had visual acuity 20/20 right eye, 20/25 left eye and unremarkable anterior segment and retinal examination. Optical coherence tomography (OCT) scanning demonstrated parafoveal thinning and subfoveal hyperreflectant material. Patient 2 had visual acuity 20/20 both eyes, with dense nuclear cataract both eyes...
March 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29419645/current-concepts-in-true-exfoliation-syndrome
#10
Chaiwat Teekhasaenee
True exfoliation syndrome (TEX, capsular delamination or schisis) is a unique condition in which characteristic lamellar separation of the anterior lens capsule occurs. Because the delaminated membrane is remarkably thin and translucent, and initial detachment occurs peripherally along the zonular insertions, the condition tends to be overlooked on routine examination with inadequate mydriasis. The condition increases with age and despite the classic association with occupations involving intense heat, most cases are idiopathic...
February 6, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29392397/efficiency-and-measurements-agreement-between-swept-source-oct-and-low-coherence-interferometry-biometry-systems
#11
Jorge A Calvo-Sanz, Alejandro Portero-Benito, Alfonso Arias-Puente
PURPOSE: To compare and evaluate the agreement between the measurements obtained with a swept-source optical coherence tomography (OCT)-based biometer, the IOLMaster® 700 (IOLM), and those obtained by an optical biometer based on optical low-coherence interferometry (OLCI), the Aladdin (ALD); To evaluate the ability to perform biometric measurements in those eyes with transparency alterations. METHODS: Fifty-five eyes of 55 subjects were included in this study...
March 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29388156/unexpected-potential-protective-associations-between-outdoor-air-pollution-and-cataracts
#12
Yoon-Hyeong Choi, Su Jin Park, Hae Jung Paik, Mee Kum Kim, Won Ryang Wee, Dong Hyun Kim
Air pollution is one of the biggest public health issues, and the eye is continuously exposed to multiple outdoor air pollution. However, to date, no large-scale study has assessed the relationship between air pollutants and cataracts. We investigated associations between outdoor air pollution and cataracts in the Korean population. A population-based cross-sectional study was performed using data from the Korea National Health and Nutrition Examination Survey, including 18,622 adults more than 40 years of age...
April 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29335103/new-objective-lens-density-quantification-method-using-swept-source-optical-coherence-tomography-technology-comparison-with-existing-methods
#13
Christophe Panthier, Justine Burgos, Helene Rouger, Alain Saad, Damien Gatinel
PURPOSE: To assess a new objective cataract grading method based on lens densitometry on swept-source optical coherence tomography (SS-OCT) scans provided by the IOLMaster 700. SETTINGS: Rothschild Foundation, Paris, France. DESIGN: Prospective case series. METHODS: All patients consulting for cataract evaluation who provided their consent to participate in the study were included. A history of eye surgery, corneal or retinal disorders, and ocular dryness were exclusion criteria...
December 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29251400/ophthalmic-examination-findings-and-intraocular-pressures-in-wild-caught-african-giant-pouched-rats-cricetomys-spp
#14
Amanda R Heller, Eric C Ledbetter, Bhupinder Singh, Danielle N Lee, Alexander G Ophir
PURPOSE: To report ophthalmic examination findings and intraocular pressures (IOPs) in wild-caught African giant pouched rats (Cricetomys ansorgei and gambianus) from Tanzania and Ghana. PROCEDURES: After being placed under general anesthesia for examination, slit-lamp biomicroscopy before and after pharmacologic mydriasis and indirect ophthalmoscopy was performed. Eyes were fluorescein stained and IOPs measured by rebound tonometry using the TonoVet® . RESULTS: Thirty-two sexually mature pouched rats (64 eyes) were examined, including 16 males and 16 females...
December 18, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29208829/comparative-analysis-of-endothelial-cell-loss-following-phacoemulsification-in-pupils-of-different-sizes
#15
RANDOMIZED CONTROLLED TRIAL
Rakesh Maggon, Raghudev Bhattacharjee, Sandeep Shankar, Rajesh Chandra Kar, Vivek Sharma, Shyamal Roy
PURPOSE: To compare Endothelial cell(EC) loss following Phacoemulsification (PKE) in pupils of different sizes. METHODS: A prospective double masked observational study in which a total of 150 eyes of 150 patients between 50 & 70 years of age with senile cataract of nuclear sclerosis grade II were enrolled. Patients were allocated into three groups of 50 eyes each in Group A (pupil size <5 mm), Group B (pupil size 5-7 mm) and Group C (pupil size >7 mm)...
December 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29188470/femtosecond-laser-assisted-cataract-surgery-with-bimanual-technique-learning-curve-for-an-experienced-cataract-surgeon
#16
Gian Maria Cavallini, Tommaso Verdina, Michele De Maria, Elisa Fornasari, Elisa Volpini, Luca Campi
PURPOSE: To describe the intraoperative complications and the learning curve of microincision cataract surgery assisted by femtosecond laser (FLACS) with bimanual technique performed by an experienced surgeon. METHODS: It is a prospective, observational, comparative case series. A total of 120 eyes which underwent bimanual FLACS by the same experienced surgeon during his first experience were included in the study; we considered the first 60 cases as Group A and the second 60 cases as Group B...
November 29, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29182452/exome-array-analysis-of-nuclear-lens-opacity
#17
Stephanie J Loomis, Alison P Klein, Kristine E Lee, Fei Chen, Samantha Bomotti, Barbara Truitt, Sudha K Iyengar, Ronald Klein, Barbara E K Klein, Priya Duggal
PURPOSE: Nuclear cataract is the most common subtype of age-related cataract, the leading cause of blindness worldwide. It results from advanced nuclear sclerosis, or opacity in the center of the optic lens, and is affected by both genetic and environmental risk factors, including smoking. We sought to understand the genetic factors associated with nuclear sclerosis through interrogation of rare and low frequency coding variants using exome array data. METHODS: We analyzed Illumina Human Exome Array data for 1,488 participants of European ancestry in the Beaver Dam Eye Study who were without cataract surgery for association with nuclear sclerosis grade, controlling for age and sex...
June 2018: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29164235/incidence-progression-and-risk-factors-for-cataract-in-type-2-diabetes
#18
Sangeetha Srinivasan, Rajiv Raman, Gayathri Swaminathan, Suganeswari Ganesan, Vaitheeswaran Kulothungan, Tarun Sharma
Purpose: We report the 4-year incidence, progression, and risk factors of cataract subtypes in type 2 diabetes. Methods: A total of 779 subjects completed baseline and 4-year follow-up. Results: The incidences of nuclear opalescence (NO), nuclear color (NC), cortical cataract (CC), and posterior subcapsular cataract (PSC) were 70%, 55.2%, 25.7%, and 7.3%, respectively. One-step progressions of NO, NC, CC, and PSC were 14.3%, 16.1%, 8.8%, and 8...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29117413/comparison-of-wound-sealability-between-femtosecond-laser-constructed-and-manual-clear-corneal-incisions-in-patients-undergoing-cataract-surgery-a-pilot-study
#19
Harvey Siy Uy, Sunil Shah, Mark Packer
PURPOSE: To compare the sealability of femtosecond laser-constructed and manual clear corneal incisions (CCIs) in patients undergoing cataract surgery. METHODS: This prospective, randomized study included 62 eyes of 62 patients with cataract grade 1 to 2 (LOCS scale). The patients were randomly assigned (1:1) for creation of either manual CCI (with a 2.4-mm keratome) or femtosecond laser-assisted CCI (LENSAR, Inc., Orlando, FL) (31 eyes in each group) before undergoing femtosecond laser-assisted cataract surgery...
November 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29038778/ophthalmological-abnormalities-in-wild-european-hedgehogs-erinaceus-europaeus-a-survey-of-300-animals
#20
David Williams, Nina Adeyeye, Erni Visser
In this study we aimed to examine wild European hedgehogs ( Erinaceus europaeus) in rescue centres and to determine ocular abnormalities in this animal population. Three hundred animals varying in age from 2 months to 5 years were examined, 147 being male and 153 female. All animals were evaluated with direct and indirect ophthalmoscopy and slit lamp biomicroscopy in animals where lesions were detected. Tonometry using the Tonovet rebound tonometer was undertaken in selected animals as was assessment of tear production using the Schirmer I tear test...
2017: Open Veterinary Journal
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