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https://www.readbyqxmd.com/read/29117413/comparison-of-wound-sealability-between-femtosecond-laser-constructed-and-manual-clear-corneal-incisions-in-patients-undergoing-cataract-surgery-a-pilot-study
#1
Harvey Siy Uy, Sunil Shah, Mark Packer
PURPOSE: To compare the sealability of femtosecond laser-constructed and manual clear corneal incisions (CCIs) in patients undergoing cataract surgery. METHODS: This prospective, randomized study included 62 eyes of 62 patients with cataract grade 1 to 2 (LOCS scale). The patients were randomly assigned (1:1) for creation of either manual CCI (with a 2.4-mm keratome) or femtosecond laser-assisted CCI (LENSAR, Inc., Orlando, FL) (31 eyes in each group) before undergoing femtosecond laser-assisted cataract surgery...
November 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29038778/ophthalmological-abnormalities-in-wild-european-hedgehogs-erinaceus-europaeus-a-survey-of-300-animals
#2
David Williams, Nina Adeyeye, Erni Visser
In this study we aimed to examine wild European hedgehogs (Erinaceus europaeus) in rescue centres and to determine ocular abnormalities in this animal population. Three hundred animals varying in age from 2 months to 5 years were examined, 147 being male and 153 female. All animals were evaluated with direct and indirect ophthalmoscopy and slit lamp biomicroscopy in animals where lesions were detected. Tonometry using the Tonovet rebound tonometer was undertaken in selected animals as was assessment of tear production using the Schirmer I tear test...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/28975669/refractive-error-in-chinese-with-type-2-diabetes-and-its-association-with-glycaemic-control
#3
E Song, Deng-Juan Qian, Shan Wang, Cailian Xu, Chen-Wei Pan
BACKGROUND: The aim of this study was to determine the prevalence of refractive errors and their association with glycaemic control among adults with type 2 diabetes mellitus (T2DM) in eastern China. METHODS: A community-based survey, including 913 adults with T2DM aged 30 to 89 years, was conducted. Refractive error was assessed by autorefraction, after which subjective refraction was performed. Ocular biometric parameters were measured by non-contact partial coherence laser interferometry...
October 3, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28956215/timing-of-vitrectomy-for-retained-lens-fragments-after-cataract-surgery
#4
REVIEW
Travis Peck, Janice Park, Asima Bajwa, Yevgeniy Shildkrot
PURPOSE: To determine the outcomes of early (less than 7 inter-operative days) versus late (7 or greater inter-operative days) vitrectomy in patients with retained lens fragments in the posterior segment after cataract surgery. METHODS: This was a retrospective review of all patients underwent pars plana vitrectomy for retained lens fragments at the University of Virginia Hospital from 2002 to 2015. RESULTS: Forty-one eyes were included in the analysis...
September 27, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28943754/pinus-densiflora-bark-extract-prevents-selenite-induced-cataract-formation-in-the-lens-of-sprague-dawley-rat-pups
#5
Jun Kim, Se-Young Choung
PURPOSE: Rat pups treated with sodium selenite are typically used as an in vivo model to mimic age-related nuclear cataract. Reactive oxygen species (ROS) production, lipid peroxidation, reduction of antioxidant enzymes, crystalline proteolysis, and apoptosis are considered factors that contribute to pathogenesis of age-related nuclear cataract. In the present study, we investigated whether Pinus densiflora bark extract has potential to prevent cataract formation and elucidated the underlying mechanism...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28935513/non-invasive-tryptophan-fluorescence-measurements-as-a-novel-method-of-grading-cataract
#6
Jesper Høiberg Erichsen, Aurore Mensah, Line Kessel
Development of non-invasive treatments for cataract calls for a sensitive diagnostic assay. We conducted a study to test whether the ratio of folded tryptophan to non-tryptophan fluorescence emission (F-factor) may be used for grading cataracts in human lenses. The F-factor was measured on aspirated lens material from eyes undergoing femtosecond laser assisted cataract surgery (FLACS) and was compared to a preoperative optical grading of cataract using Scheimpflug imaging. The preoperative optical grading allocated the cataracts to 1 of 4 categories according to the density of the cataract...
September 19, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28912863/a-novel-mutation-in-the-hepatocyte-nuclear-factor-1%C3%AE-gene-in-maturity-onset-diabetes-of-the-young-5-with-multiple-renal-cysts-and-pancreas-hypogenesis-a-case-report
#7
You Lv, Zhuo Li, Kan He, Ying Gao, Xianchao Xiao, Yujia Liu, Guixia Wang
A 17-year-old Chinese male was hospitalized exhibiting hyperglycemia and increased serum urea nitrogen and creatinine levels in addition to weight loss. The patient was treated with gliclazide. The patient was 150 cm tall, weighed 35 kg and had no family history of diabetes or kidney disease. Physical examination revealed cephalus quadratus, rachitic rosary and a visible toe-out gait. Laboratory examinations revealed that the patient's fasting plasma glucose and glycosylated hemoglobin levels were markedly increased, fasting plasma C-peptide level was slightly increased and no peak 2 h postprandial was observed...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28864287/age-related-cataracts-role-of-unfolded-protein-response-ca-2-mobilization-epigenetic-dna-modifications-and-loss-of-nrf2-keap1-dependent-cytoprotection
#8
REVIEW
Palsamy Periyasamy, Toshimichi Shinohara
Age-related cataracts are closely associated with lens chronological aging, oxidation, calcium imbalance, hydration and crystallin modifications. Accumulating evidence indicates that misfolded proteins are generated in the endoplasmic reticulum (ER) by most cataractogenic stresses. To eliminate misfolded proteins from cells before they can induce senescence, the cells activate a clean-up machinery called the ER stress/unfolded protein response (UPR). The UPR also activates the nuclear factor-erythroid-2-related factor 2 (Nrf2), a central transcriptional factor for cytoprotection against stress...
September 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28831307/changes-in-intraocular-straylight-and-visual-acuity-with-age-in-cataracts-of-different-morphologies
#9
REVIEW
Sonia Gholami, Nicolaas J Reus, Thomas J T P van den Berg
PURPOSE: To investigate the significance of difference in straylight of cataract eyes with different morphologies, as a function of age and visual acuity. METHODS: A literature review to collect relevant papers on straylight, age, and visual acuity of three common cataract morphologies leads to including five eligible papers for the analysis. The effect of morphology was incorporated to categorize straylight dependency on the two variables. We also determined the amount of progression in a cataract group using a control group...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28755661/association-of-alpha-a-crystallin-polymorphisms-with-susceptibility-to-nuclear-age-related-cataract-in-a-han-chinese-population
#10
Zhennan Zhao, Qi Fan, Peng Zhou, HongFei Ye, Lei Cai, Yi Lu
BACKGROUND: Alpha A-crystallin (CRYAA) is considered critical for the maintenance of lens transparency and is related to the pathogenesis of age-related cataracts (ARCs), especially the nuclear subtype. As the 5' untranslated region (5' UTR) modulates gene expression, the purpose of current study was to investigate whether single nucleotide polymorphisms (SNPs) in the 5' UTR of CRYAA were associated with susceptibility to ARC in a Han Chinese population and to clarify the mechanism of this association...
July 29, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28728538/effects-of-cataract-opacity-and-surgery-on-sleep-quality
#11
Aya Kokune-Takahashi, Masahiko Ayaki, Kazuo Tsubota, Kazuno Negishi
This study aimed to identify the type of cataract opacity associated with subjective sleep quality for cataract patients. A total of 180 consecutive patients (average age 74.2 years) underwent cataract surgery with implantation of an ultraviolet-blocking or blue light-blocking intraocular lens. The participants' subjective sleep quality was evaluated using the Pittsburgh sleep quality index (PSQI) before and at 2 months after surgery. Patients were divided into two groups for analysis: normal sleepers (preoperative PSQI ≤5) and poor sleepers (preoperative PSQI ≥6)...
August 29, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28728281/-a-cross-sectional-study-of-cataract-in-residents-with-type-2-diabetes-living-in-xinjing-town-shanghai
#12
B J Zhu, X R Zou, Y Xu, X L Bai, M Lu, Y Y Ma, L N Lu, J F Zhu, H D Zou, X Xu
Objective: To investigate the prevalence, subtypes and risk factors of cataract in type 2 diabetic individuals. Methods: Geographically defined cluster sampling method was used in this population-based, cross-sectional study. There were 7 756 type 2 diabetes individuals in Xinjing Town with a residential population of 88 864. The type 2 diabetic individuals were randomly selected from 20 basic sample units in Xinjing Town of Changning District from April to June 2016. All participants received visual acuity measurement and eye examination...
July 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28724816/four-year-incidence-and-progression-of-visual-impairment-in-a-south-indian-population-with-diabetes
#13
MULTICENTER STUDY
Sangeetha Srinivasan, Rajiv Raman, Suganeswari Ganesan, Rupak Roy, Viswanathan Natarajan, Tarun Sharma
PURPOSE: The aim of this study is to investigate the 4-year incidence and progression of visual impairment (VI) and the associated risk factors for incident VI in a South Indian population with type 2 diabetes. METHODS: A total of 634 participants with type 2 diabetes were found eligible after 4 years. Visual acuity (VA) was estimated using the modified Early Treatment Diabetic Retinopathy Study protocol. VA in the better eye was considered for the assessment of VI based on the World Health Organization criteria...
July 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28722304/nrf2-as-a-target-for-prevention-of-age-related-and-diabetic-cataracts-by-against-oxidative-stress
#14
REVIEW
Xiu-Fen Liu, Ji-Long Hao, Tian Xie, Tayyab Hamid Malik, Cheng-Bo Lu, Cong Liu, Chang Shu, Cheng-Wei Lu, Dan-Dan Zhou
Cataract is one of the most important causes of blindness worldwide, with age-related cataract being the most common one. Agents preventing cataract formation are urgently required. Substantial evidences point out aggravated oxidative stress as a vital factor for cataract formation. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Kelch-like erythroid-cell-derived protein with CNC homology (ECH)-associated protein 1 (Keap1) system is considered as one of the main cellular defense mechanisms against oxidative stresses...
October 2017: Aging Cell
https://www.readbyqxmd.com/read/28662131/the-association-between-gout-and-cataract-risk-a-meta-analysis
#15
Chenqi Luo, Xinyi Chen, Hongchuan Jin, Ke Yao
PURPOSE: To evaluate the relationship between gout and age-related cataracts (ARCs). METHODS: A comprehensive literature search of the PubMed and Web of Science databases was conducted to identify papers on the association between gout and cataract risk that had been published between February 1991 and January 2017. Pooled relative risks (RRs) or odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were calculated. The random-effects model was used instead of the fixed-effects model when heterogeneity was identified, as indicated by a Cochran's Q statistic P-value <0...
2017: PloS One
https://www.readbyqxmd.com/read/28632030/ultraviolet-b-radiation-stimulates-the-interaction-between-nuclear-factor-of-activated-t-cells-5-nfat5-and-nuclear-factor-kappa-b-nf-%C3%AE%C2%BAb-in-human-lens-epithelial-cells
#16
Inyoung Chung, Young-Sool Hah, SunMi Ju, Ji-Hye Kim, Woong-Sun Yoo, Hee-Young Cho, Ji-Myong Yoo, Seong-Wook Seo, Wan-Sung Choi, Seong-Jae Kim
PURPOSE: Nuclear factor-kappa B (NF-κB) has been proposed as a therapeutic target for the treatment of cataracts. The authors investigated the relationship between nuclear factor of activated T cells 5 (NFAT5) and NF-κB in ultraviolet B (UVB)-irradiated human lens epithelial (HLE) cells. METHODS: Human lens epithelial B-3 (HLE-B3) cells were exposed to UVB light at a dose of 10 mJ/cm(2) and then incubated for 24 h. Cell viability was assessed by using the Cell Counting Kit-8 (CCK-8) assay...
February 26, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28622319/flicker-electroretinograms-recorded-with-mydriasis-free-reteval-system-before-and-after-cataract-surgery
#17
G Miura, E Sato, S Yamamoto
PurposeThe purpose of this study is to compare the amplitudes and peak times of the flicker electroretinograms (ERGs) recorded before and after cataract surgery with the RETeval system (LKC Technologies, Gaithersburg, MD, USA) from eyes without dilation.Patients and methodsThirty-two eyes of 32 patients (77.3±6.5 years) that had grade 2 Emery-Little nuclear or cortical cataract without any other abnormalities were studied. Flicker ERGs were recorded with the RETeval system under mydriatic-free conditions. Skin electrodes were used to pick-up the ERGs that were elicited by white light delivered at a rate of 28...
November 2017: Eye
https://www.readbyqxmd.com/read/28587752/dickkopf-1-inhibits-wnt3a-induced-migration-and-epithelial-mesenchymal-transition-of-human-lens-epithelial-cells
#18
Tingting Liu, Limin Zhang, Yanyan Wang, Haitao Zhang, Lin Li, Xiuli Bao
Posterior capsular opacification (PCO) is a major post-operative complication of cataract surgery. Epithelial-mesenchymal transition (EMT) contributes to PCO. We previously indicated that Wnt3a induces the EMT of human lens epithelial cells (LECs) and plays an important role in the development of PCO. The present study aimed to test the potential effect of Dickkopf-1 (Dkk1) on Wnt3a-induced cell migration and the EMT of LECs and to explore possible cellular mechanisms. The secretion of Dkk1 was reduced in the rabbit PCO model, and Dkk1 injected into the eyes post-surgical manipulation prevented PCO formation...
August 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28532933/clinical-outcomes-of-femtosecond-laser-assisted-cataract-surgery-versus-conventional-phacoemulsification-surgery-for-hard-nuclear-cataracts
#19
Xinyi Chen, Yinhui Yu, Xiaohui Song, Yanan Zhu, Wei Wang, Ke Yao
PURPOSE: To compare the outcomes between femtosecond laser-assisted cataract surgery (femtosecond group) and conventional phacoemulsification cataract surgery (conventional group) in patients with hard nuclear cataract. SETTING: Eye Center, Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou, China. DESIGN: Prospective consecutive nonrandomized comparative cohort study. METHODS: According to the Emery-Little classification, cataract patients with a grade 4 or 5 hard nuclei were assigned to 1 of the 2 groups...
April 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28524141/-risk-of-senile-cataract-among-nuclear-industry-workers
#20
E V Bragin, T V Azizova, M V Bannikova
AIM: to assess the relative risk (RR) of senile cataract in a cohort of workers occupationally exposed to external gamma-rays over a long time period. MATERIAL AND METHODS: The RR of cataract development was studied in a cohort of nuclear workers that were first employed in 1948-1982 and followed up till the end of 2008 (n=22,377; females, 25.4%). The mean age at initial employment was 24.9 years. The mean cumulative gamma-ray dose was 0.54 Sv in males and 0.44 Sv in females...
2017: Vestnik Oftalmologii
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