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https://www.readbyqxmd.com/read/28632030/ultraviolet-b-radiation-stimulates-the-interaction-between-nuclear-factor-of-activated-t-cells-5-nfat5-and-nuclear-factor-kappa-b-nf-%C3%AE%C2%BAb-in-human-lens-epithelial-cells
#1
Inyoung Chung, Young-Sool Hah, SunMi Ju, Ji-Hye Kim, Woong-Sun Yoo, Hee-Young Cho, Ji-Myong Yoo, Seong-Wook Seo, Wan-Sung Choi, Seong-Jae Kim
PURPOSE: Nuclear factor-kappa B (NF-κB) has been proposed as a therapeutic target for the treatment of cataracts. The authors investigated the relationship between nuclear factor of activated T cells 5 (NFAT5) and NF-κB in ultraviolet B (UVB)-irradiated human lens epithelial (HLE) cells. METHODS: Human lens epithelial B-3 (HLE-B3) cells were exposed to UVB light at a dose of 10 mJ/cm(2) and then incubated for 24 h. Cell viability was assessed by using the Cell Counting Kit-8 (CCK-8) assay...
February 26, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28622319/flicker-electroretinograms-recorded-with-mydriasis-free-reteval-system-before-and-after-cataract-surgery
#2
G Miura, E Sato, S Yamamoto
PurposeThe purpose of this study is to compare the amplitudes and peak times of the flicker electroretinograms (ERGs) recorded before and after cataract surgery with the RETeval system (LKC Technologies, Gaithersburg, MD, USA) from eyes without dilation.Patients and methodsThirty-two eyes of 32 patients (77.3±6.5 years) that had grade 2 Emery-Little nuclear or cortical cataract without any other abnormalities were studied. Flicker ERGs were recorded with the RETeval system under mydriatic-free conditions. Skin electrodes were used to pick-up the ERGs that were elicited by white light delivered at a rate of 28...
June 16, 2017: Eye
https://www.readbyqxmd.com/read/28587752/dickkopf-1-inhibits-wnt3a-induced-migration-and-epithelial-mesenchymal-transition-of-human-lens-epithelial-cells
#3
Tingting Liu, Limin Zhang, Yanyan Wang, Haitao Zhang, Lin Li, Xiuli Bao
Posterior capsular opacification (PCO) is a major post-operative complication of cataract surgery. Epithelial-mesenchymal transition (EMT) contributes to PCO. We previously indicated that Wnt3a induces the EMT of human lens epithelial cells (LECs) and plays an important role in the development of PCO. The present study aimed to test the potential effect of Dickkopf-1 (Dkk1) on Wnt3a-induced cell migration and the EMT of LECs and to explore possible cellular mechanisms. The secretion of Dkk1 was reduced in the rabbit PCO model, and Dkk1 injected into the eyes post-surgical manipulation prevented PCO formation...
June 3, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28532933/clinical-outcomes-of-femtosecond-laser-assisted-cataract-surgery-versus-conventional-phacoemulsification-surgery-for-hard-nuclear-cataracts
#4
Xinyi Chen, Yinhui Yu, Xiaohui Song, Yanan Zhu, Wei Wang, Ke Yao
PURPOSE: To compare the outcomes between femtosecond laser-assisted cataract surgery (femtosecond group) and conventional phacoemulsification cataract surgery (conventional group) in patients with hard nuclear cataract. SETTING: Eye Center, Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou, China. DESIGN: Prospective consecutive nonrandomized comparative cohort study. METHODS: According to the Emery-Little classification, cataract patients with a grade 4 or 5 hard nuclei were assigned to 1 of the 2 groups...
April 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28524141/-risk-of-senile-cataract-among-nuclear-industry-workers
#5
E V Bragin, T V Azizova, M V Bannikova
AIM: to assess the relative risk (RR) of senile cataract in a cohort of workers occupationally exposed to external gamma-rays over a long time period. MATERIAL AND METHODS: The RR of cataract development was studied in a cohort of nuclear workers that were first employed in 1948-1982 and followed up till the end of 2008 (n=22,377; females, 25.4%). The mean age at initial employment was 24.9 years. The mean cumulative gamma-ray dose was 0.54 Sv in males and 0.44 Sv in females...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28507388/congenital-nuclear-cataracts-in-a-holstein-dairy-herd
#6
Stephanie Osinchuk, Lyall Petrie, Marina Leis, Fritz Schumann, Bianca Bauer, Lynne Sandmeyer, Kayla Madder, Fiona Buchanan, Bruce Grahn
This report describes congenital nuclear cataracts and posterior lenticonus in a closed purebred Holstein dairy herd in Canada. Ophthalmic examinations were completed on 30 male and 249 female cattle aged newborn to 10 years old. Nutritional, infectious, and toxic etiologies were investigated. Necropsies of 3 affected calves were performed and eyes of 2 additional affected calves were examined with light microscopy. Bilateral nuclear cataracts were identified in 53/279 (19%) animals. Additional congenital anomalies observed included posterior lenticonus, iris to lens persistent pupillary membranes (n = 7), and lenticular colobomata (n = 1)...
May 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28500744/risk-of-cataract-among-interventional-cardiologists-and-catheterization-lab-staff-a-systematic-review-and-meta-analysis
#7
Ahmed Elmaraezy, Mostafa Ebraheem Morra, Abdelrhman Tarek Mohammed, Ahmed Al-Habaa, Ahmed Elgebaly, Ahmed Abdelmotaleb Ghazy, Adham M Khalil, Nguyen Tien Huy, Kenji Hirayama
OBJECTIVES: We performed a systematic review and meta-analysis to assess the risk of developing a radiation-induced cataract in interventional cardiologists (ICs). BACKGROUND: ICs are forced to radiation exposure during cardiac catheterization procedures. Since the eye lens is one of the most radiosensitive organs in the body, ICs are highly susceptible to develop a radiation-induced cataract. METHOD: We performed a systematic literature search of nine electronic databases to retrieve studies that report cataract among interventional cardiologists...
May 13, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28484672/photoperiodic-regime-influences-onset-of-lens-opacities-in-a-non-human-primate
#8
Marko Dubicanac, Julia Strueve, Nadine Mestre-Frances, Jean-Michel Verdier, Elke Zimmermann, Marine Joly
BACKGROUND: Opacities of the lens are typical age-related phenomena which have a high influence on photoreception and consequently circadian rhythm. In mouse lemurs, a small bodied non-human primate, a high incidence (more than 50% when >seven years) of cataracts has been previously described during aging. Previous studies showed that photoperiodically induced accelerated annual rhythms alter some of mouse lemurs' life history traits. Whether a modification of photoperiod also affects the onset of age dependent lens opacities has not been investigated so far...
2017: PeerJ
https://www.readbyqxmd.com/read/28366368/risk-factors-for-and-diagnosis-of-pseudophakic-cystoid-macular-edema-after-cataract-surgery-in-diabetic-patients
#9
Jin Yang, Lei Cai, Zhongcui Sun, Hongfei Ye, Qi Fan, Keke Zhang, Wenyi Lu, Yi Lu
PURPOSE: To evaluate the risk factors and potential diagnostic criteria for pseudophakic cystoid macular edema (CME) in diabetic patients after phacoemulsification. SETTING: Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China. DESIGN: Prospective nonrandomized study. METHODS: Diabetic patients were followed for up to 6 months after cataract surgery and examined to evaluate their foveal thickness, macular sensitivity, and corrected distance visual acuity...
February 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28351047/postsurgical-cystoid-macular-edema
#10
Dinah Zur, Anat Loewenstein
Cystoid macular edema (CME) is a primary cause of reduced vision following both cataract and successful vitreoretinal surgery. The incidence of clinical CME following modern cataract surgery is 0.1-2.35%. Preexisting conditions such as diabetes mellitus and uveitis as well as intraoperative complications can raise the risk of postsurgical CME. The etiology of CME is not completely understood. Prolapsed or incarcerated vitreous and postoperative inflammatory processes have been proposed as causative agents. Pseudophakic CME is characterized by poor postoperative visual acuity...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28271591/a-novel-heterozygous-mutation-of-the-wfs1-gene-leading-to-constitutive-endoplasmic-reticulum-stress-is-the-cause-of-wolfram-syndrome
#11
Shuntaro Morikawa, Toshihiro Tajima, Akie Nakamura, Katsura Ishizu, Tadashi Ariga
BACKGROUND: Wolfram syndrome (WS) is a disorder characterized by the association of insulin-dependent diabetes mellitus (DM), diabetes insipidus, deafness, and optic nerve atrophy. WS is caused by WFS1 mutations encoding WFS1 protein expressed in endoplasmic reticulum (ER). During ER protein synthesis, misfolded and unfolded proteins accumulate, known as "ER stress". This is attenuated by the unfolded protein response (UPR), which recovers and maintains ER functions. Because WFS1 is a UPR component, mutant WFS1 might cause unresolvable ER stress conditions and cell apoptosis, the major causes underlying WS symptoms...
March 8, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28247339/galactose-epimerase-deficiency-expanding-the-phenotype
#12
Filipa Dias Costa, Sacha Ferdinandusse, Carla Pinto, Andrea Dias, Liesbeth Keldermans, Dulce Quelhas, Gert Matthijs, Petra A Mooijer, Luísa Diogo, Jaak Jaeken, Paula Garcia
Galactose epimerase deficiency is an inborn error of metabolism due to uridine diphosphate-galactose-4'-epimerase (GALE) deficiency. We report the clinical presentation, genetic and biochemical studies in two siblings with generalized GALE deficiency.Patient 1: The first child was born with a dysmorphic syndrome. Failure to thrive was noticed during the first year. Episodes of heart failure due to dilated cardiomyopathy, followed by liver failure, occurred between 12 and 42 months. The finding of a serum transferrin isoelectrofocusing (IEF) type 1 pattern led to the suspicion of a congenital disorder of glycosylation (CDG)...
March 1, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28245299/vitreous-humor-changes-expression-of-iron-handling-proteins-in-lens-epithelial-cells
#13
Malgorzata Goralska, Lloyd N Fleisher, M Christine McGahan
Purpose: In humans, vitrectomy is associated with development of nuclear cataracts. Iron catalyzes free radical formation causing oxidative damage, which is implicated in cataract formation. This study was designed to determine if vitreous humor, which can initiate differentiation of lens epithelial cells, would have an effect on iron-handling proteins. Methods: Cultured canine lens epithelial cells were treated with collected canine vitreous humor. Lysates of treated and control cells were separated by SDS-PAGE...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28210183/intraocular-lens-power-overestimation-in-a-patient-with-history-of-circling-keratorraphy
#14
Vasilios F Diakonis, Nilufer Yesilirmak, George D Kymionis, Sonia H Yoo
We report a case of cataract extraction and intraocular lens (IOL) power overestimation in a patient with history of hyperopia managed with circling keratorraphy. A 65-year-old female presented to our institute complaining of decreased vision in both eyes. The patient had a history of bilateral hyperopia that was managed 20 years ago (1994) with circling keratorraphy. At presentation her uncorrected distance visual acuity (UDVA) was 20/70 and 20/60 in her right eye (OD) and left eye (OS), respectively, while her corrected distance visual acuity (CDVA) was 20/25 OD and 20/25 OS with manifest refraction of -0...
July 2016: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28192585/correlations-of-objective-metrics-for-quantifying-dysfunctional-lens-syndrome-with-visual-acuity-and-phacodynamics
#15
Fernando Faria-Correia, Isaac Ramos, Bernardo Lopes, Tiago Monteiro, Nuno Franqueira, Renato Ambrósio
PURPOSE: To study the relationship between objective metrics for quantifying crystalline lens dysfunction with visual impairment and phacodynamics parameters in age-related nuclear cataracts. METHODS: A total of 51 eyes (34 patients) with age-related nuclear cataract had phacoemulsification. The Dysfunctional Lens Index (0 to 10 points) was measured by a ray-tracing aberrometry (iTrace Visual Function Analyzer; Tracey Technologies, Houston, TX). The average lens density (0 to 100) was evaluated using a rotating Scheimpflug system (Pentacam HR; Oculus Optikgeräte GmbH, Wetzlar, Germany), and the nuclear opalescence score was subjectively assessed using the Lens Opacities Classification System III (LOCS III)...
February 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28184151/wound-and-surface-temperatures-in-vivo-in-torsional-and-longitudinal-modalities-of-ultrasound-in-coaxial-microincisional-cataract-surgery
#16
Swapna Nair, Ramachandran Unnikrishnan Nair
BACKGROUND: To study phacoemulsification probe shaft/wound and corneal surface/tip temperatures in vivo during longitudinal, torsional and combined phacoemulsification modes and their relationship to machine parameters. DESIGN: This was a prospective study at Chaithanya Eye Hospital and Research Institute, Trivandrum, India (tertiary). PARTICIPANTS: Twenty-two eyes of 22 patients were randomized into six groups depending on the grade of nuclear sclerosis (NS) and the type of ultrasound used: Group 1, torsional in NS2; Group 2, torsional in NS3; Group 3, torsional with intermittent longitudinal in NS2; Group 4, torsional with intermittent longitudinal in NS3; Group 5, longitudinal in NS2; Group 6, longitudinal in NS3...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28182590/lens-opacity-and-hydrogen-sulfide-in-a-new-zealand-geothermal-area
#17
Michael N Bates, Ian L Bailey, Robert B DiMartino, Karl Pope, Julian Crane, Nick Garrett
PURPOSE: Hydrogen sulfide (H2S) is a highly toxic gas with well-established, acute irritation effects on the eye. The population of Rotorua, New Zealand, sited on an active geothermal field, has some of the highest ambient H2S exposures in the world. Evidence from ecological studies in Rotorua has suggested that H2S is associated with cataract. The purpose of the present study was, using more detailed exposure characterization, clinical examinations, and anterior eye photography, to more directly investigate this previously reported association...
April 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28146420/a-silent-mutation-in-human-alpha-a-crystallin-gene-in-patients-with-age-related-nuclear-or-cortical-cataract
#18
Bharani K Mynampati, Thungapathra Muthukumarappa, Sujata Ghosh, Jagat Ram
A cataract is a complex multifactorial disease that results from alterations in the cellular architecture, i.e. lens proteins. Genes associated with the development of lens include crystallin genes. Although crystallins are highly conserved proteins among vertebrates, a significant number of polymorphisms exist in human population. In this study, we screened for polymorphisms in crystallin alpha A (CRYAA) and alpha B (CRYAB) genes in 200 patients over 40 years of age, diagnosed with age-related cataract (ARC; nuclear and cortical cataracts)...
May 20, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28139160/the-relation-between-sleep-disruption-and-cataract-in-a-large-population-based-study
#19
Yanjun Chen, David M Nondahl, Carla R Schubert, Barbara E K Klein, Ronald Klein, Karen J Cruickshanks
PURPOSE: To investigate the relation between sleep disruption and nuclear cataract, as well as the impact of cataract removal on sleep, in two discrete population-based cohorts. METHODS: This is a cross-sectional study of 5070 participants from three large longitudinal epidemiologic studies of age-related eye disease, hearing, olfaction, and cognition. Slit-lamp photos of the lens were obtained to grade nuclear cataract using a standardized protocol. The quality of sleep was assessed using a modified Wisconsin Sleep Cohort Study questionnaire...
April 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28128997/roasting-enhances-the-anti-cataract-effect-of-coffee-beans-ameliorating-selenite-induced-cataracts-in-rats
#20
Nana Ishimori, Jun Oguchi, Yosuke Nakazawa, Kenji Kobata, Megumi Funakoshi-Tago, Hiroomi Tamura
PURPOSE: Coffee is a widely consumed beverage. While recent studies have linked its intake to a reduced risk of cataracts, caffeine is believed to be the key factor for its effect. To know how roasting beans affects the effect of coffee on cataract formation, we investigated the impact roasting using a selenite-induced cataract rat model. MATERIALS AND METHODS: Sprague Dawley rats were given a single injection of sodium selenite, which induced formation of nuclear cataracts by day 6, with or without coffee intake (100% coffee, 0...
January 27, 2017: Current Eye Research
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