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2+ nuclear cataracts

Avner Belkin, Adi Abulafia, Adi Michaeli, Shay Ofir, Ehud I Assia
BACKGROUND: Temperature profiles at the corneal wound of coaxial mini-incision (2.4 mm) cataract surgery and sleeveless micro-incision (1.1 mm) cataract surgery were compared. DESIGN: Prospective, controlled, paired-eye clinical trial conducted in a tertiary care hospital PARTICIPANTS: Twenty patients with mild to moderate bilateral nuclear sclerotic cataract. METHODS: Twenty patients underwent bilateral cataract surgery within a one-month period...
October 12, 2016: Clinical & Experimental Ophthalmology
Soujanya Kaup, Siddharudha Shivalli, Divyalakshmi Ks, Cynthia Arunachalam, Rejitha Chinnu Varghese
INTRODUCTION: Corneal endothelial damage following phacoemulsification is still one of the major concerns of modern day cataract surgery. Although many techniques have been proposed, the risks of posterior capsular rupture and corneal endothelium damage persist. In theory, damage to the corneal endothelium is minimised by delivering the lowest phaco energy only in the direction necessary to emulsify the lens nucleus. Hence, it is believed that the bevel of the needle should be turned towards the nucleus or the nuclear fragment (ie, bevel-down...
2016: BMJ Open
Abdul Fattah Memon, Pir Salim Mahar, Muhammad Saleh Memon, Seema N Mumtaz, Sikander Ali Shaikh, Muhammad Faisal Fahim
OBJECTIVE: To determine the frequency and types of age-related cataract in type 2 diabetic patients compared to non-diabetics. METHODS: This comparative, cross-sectional study was carried out at Al-Ibrahim Eye Hospital, Karachi, from July 2014 to June 2015, and comprised both diabetics and non-diabetics. All patients were selected from the out-patient department and had their full ocular examination done, including retinal screening of diabetic patients with non-mydriatic fundus camera...
October 2016: JPMA. the Journal of the Pakistan Medical Association
Soon-Phaik Chee, Melissa H Y Wong, Aliza Jap
PURPOSE: To assess the role of femtosecond laser technology in the management of severely subluxated cataracts DESIGN: Retrospective, interventional case series METHODS: All eyes with subluxated cataract seen between July 2012 and June 2015 were assessed for suitability for femtosecond laser assisted cataract surgery, with the use of capsular tension devices. Participants with subluxated cataracts of at least 6 clock hours of zonular weakness were included in the study. Data collected included patient demographics, pre and post-operative best corrected visual acuity (BCVA), nuclear density, extent of zonular weakness, completeness of capsulotomy and complications...
September 23, 2016: American Journal of Ophthalmology
You Na Kim, Jin Hyoung Park, Hungwon Tchah
Purpose. To quantify whole lens and nuclear lens densities using anterior-segment optical coherence tomography (OCT) with a liquid optics interface and evaluate their correlation with Lens Opacities Classification System III (LOCS III) lens grading and corrected distance visual acuity (BCVA). Methods. OCT images of the whole lens and lens nucleus of eyes with age-related nuclear cataract were analyzed using ImageJ software. The lens grade and nuclear density were represented in pixel intensity units (PIU) and correlations between PIU, BCVA, and LOCS III were assessed...
2016: Journal of Ophthalmology
Anirbaan Mukherjee, Richard A Bone
BACKGROUND: Cataract, a leading cause of vision impairment, is due to the lens becoming excessively optically dense. Change in the lens optical density (LOD) could be a useful indicator of incipient nuclear cataract and would necessitate the development of accurate measurement techniques. Mapcat sf™ is a heterochromatic flicker photometer for measuring macular pigment optical density (MPOD) under photopic conditions. In the process, it also measures LOD that is needed in the calculation of MPOD...
2016: Eye and Vision (London, England)
Haiyan Zhou, Hong Yan, Weijia Yan, Xinchuan Wang, Yong Ma, Jianping Wang
PURPOSE: The goal of this study was to identify and quantify the differentially expressed proteins in human nuclear cataract with different axial lengths. METHODS: Thirty-six samples of human lens nuclei with hardness grade III or IV were obtained during cataract surgery with extracapsular cataract extraction (ECCE). Six healthy transparent human lens nuclei were obtained from fresh healthy cadaver eyes during corneal transplantation surgery. The lens nuclei were divided into seven groups (six lenses in each group) according to the optic axis: Group A (mean axial length 28...
2016: Molecular Vision
Robert William Andrew Machuk, Sourabh Arora, Morley Kutzner, Karim F Damji
OBJECTIVE: Wet labs are an important part of ophthalmology residency training in order to develop intraocular surgical proficiency. The purpose of this study was to compare the effectiveness of formalin versus microwave treatment to produce porcine cadaveric cataracts. DESIGN: This study was a comparative observational study at a single centre. METHODS: Cataracts were created through the injection of 0.1 mL of 100% ethanol into the anterior chamber followed by the infiltration of 0...
August 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Olatz Barandika, Maitane Ezquerra-Inchausti, Ander Anasagasti, Ainara Vallejo-Illarramendi, Irantzu Llarena, Lucia Bascaran, Txomin Alberdi, Giacomo De Benedetti, Javier Mendicute, Javier Ruiz-Ederra
In this work we have analyzed the expression levels of the main aquaporins (AQPs) expressed in human lens epithelial cells (HLECs) using 112 samples from patients treated with cataract surgery and 36 samples from individuals treated with refractive surgery, with transparent lenses as controls. Aquaporin-1 (AQP1) is the main AQP, representing 64.1% of total AQPs in HLECs, with aquaporin-5 (AQP5) representing 35.9% in controls. A similar proportion of each AQP in cataract was found. Although no differences were found at the mRNA level compared to controls, a significant 1...
October 2016: Biochimica et Biophysica Acta
Lingam Vijaya, Rashima Asokan, Manish Panday, Ronnie George
BACKGROUND: To report the risk of cataract progression among primary angle closure suspects (PACS) 6 years after they underwent laser peripheral iridotomy (LPI). METHODS: In the Chennai Eye Disease Incidence Study, 6 years after their baseline evaluation, 4421 subjects were examined again. As part of a detailed evaluation cataract was graded using the Lens Opacities Classification System II; progression was defined as change of cataract by two or more grades or history of cataract surgery in the 6-year period...
August 2, 2016: British Journal of Ophthalmology
Gian Marco Tosi, Angelo Balestrazzi, Stefano Baiocchi, Antonio Tarantello, Gabriele Cevenini, Davide Marigliani, Francesco Simi
PURPOSE: To assess the impact of phacoemulsification performed one week before pars plana vitrectomy versus combined phacovitrectomy on postoperative anterior segment status and final functional and anatomical outcomes in phakic patients affected by complex rhegmatogenous retinal detachment. METHODS: The authors retrospectively reviewed the records of 59 phakic patients affected by complex rhegmatogenous retinal detachment. Twenty-nine patients underwent cataract surgery 7 days before vitrectomy (preemptive cataract surgery-Group 1), whereas 30 patients underwent combined phacovitrectomy (Group 2)...
July 26, 2016: Retina
Yan Shenshen, Wang Minshu, Yuan Qing, Liu Yang, Zhai Suodi, Wang Wei
Blue light plays an important role in circadian photoentrainment by stimulating the melanopsin-expressing photosensitive retinal ganglion cells. Age-related cataract causes progressive loss of blue light transmission, which may lead to changes in circadian rhythm and sleep quality. In theory, increased light transmission by cataract surgery may improve circadian misalignment and sleep quality, while the effect of cataract surgery on circadian rhythm is not well understood. In this study, we assessed 30 binocular age-related nuclear cataract patients (aged 72...
2016: Chronobiology International
Xiaohang Wu, Erping Long, Haotian Lin, Yizhi Liu
Congenital cataract (CC) is the primary cause of treatable childhood blindness worldwide. The establishment of reliable, epidemiological estimates is an essential first step towards management strategies. We undertook an initial systematic review and meta-analysis to estimate the prevalence and other epidemiological characteristics of CC. PubMed, Medline, Web of Science, Embase, and Cochrane Library were searched before January 2015. A meta-analysis with random-effects model based on a proportions approach was performed to determine the population-based prevalence of CC and to describe the data regarding the laterality, morphology, associated comorbidities and etiology...
2016: Scientific Reports
Viviana M Berthoud, Peter J Minogue, Paul A Lambert, Joseph I Snabb, Eric C Beyer
Mice expressing connexin50D47A (Cx50D47A) exhibit nuclear cataracts and impaired differentiation. Cx50D47A does not traffic properly, and homozygous mutant lenses show increased levels of the stress-responsive αB-crystallins. Therefore, we assessed whether expression of Cx50D47A led to endoplasmic reticulum (ER) stress in the lens in vivo Although pharmacologic induction of ER stress can be transduced by three different pathways, we found no evidence for activation of the IRE1α or ATF6 pathways in Cx50D47A-expressing lenses...
August 19, 2016: Journal of Biological Chemistry
Ivan Tanev, Vesselin Tanev, Anastasios John Kanellopoulos
PURPOSE: To evaluate corneal endothelial cell density (ECD) and morphology after cataract surgery using coaxial ultrasound (US) phacoemulsification or a recently introduced coaxial nanosecond laser technique. SETTING: Department of Ophthalmology, Medical University of Sofia, Sofia, Bulgaria. DESIGN: Prospective cohort study. METHODS: Coaxial US phacoemulsification was performed in 1 eye (US group) and coaxial nanosecond laser-assisted cataract surgery in the contralateral eye (laser group) of the same patient...
May 2016: Journal of Cataract and Refractive Surgery
Yong Wang, Fei Li, Guowei Zhang, Lihua Kang, Huaijin Guan
BACKGROUND: Ultraviolet-B (UVB) exposure attributes to the formation of age-related nuclear cataract (ARNC), which is mediated with DNA damage. DNA damage, an important factor for pathogenesis of ARNC, is induced by UVB, and is generally resolved by the nucleotide excision repair (NER) repair mechanism. Cockayne syndrome complementation group B (CSB) protein coded by ERCC6 is a vital component for NER. However, we found no association between selected ERCC6 polymorphisms and ARNC. In this study, we investigated whether UVB exposure could alter ERCC6 expression and the process could involve epigenetic changes of DNA methylation and/or histone acetylation of ERCC6 in the lens epithelial cells (LECs)...
2016: Clinical Epigenetics
Thulasiraj D Ravilla, Sanjeev Gupta, Ravilla D Ravindran, Praveen Vashist, Tiruvengada Krishnan, Giovanni Maraini, Usha Chakravarthy, Astrid E Fletcher
BACKGROUND: Biomass cooking fuels are commonly used by Indian households especially the poorest. Cataract is highly prevalent in India and the major cause of vision loss. The evidence on biomass fuels and cataract is limited. OBJECTIVES: To examine the association of biomass cooking fuels with cataract and type of cataract. METHODS: We conducted a population-based study in north and south India using randomly sampled clusters to identify people aged 60 and over...
May 25, 2016: Environmental Health Perspectives
Hye Jin Chung, Jeong Hoon Choi, Young-Chun Lee, Su-Young Kim
PURPOSE: To determine the effect of cataract opacity type and glaucoma severity on the visual field index (VFI). METHODS: A total of 152 eyes of 152 patients were analyzed. Patients with glaucoma, previous evaluation with the Swedish Interactive Threshold Algorithm-standard 24-2 VFs, visually significant cataracts, and VFs before surgery were included in this study. Cataract opacity was classified as cortical, nuclear sclerotic, or posterior subcapsular. The patients underwent phacoemulsification cataract extraction surgery...
June 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Sarah Perez-Roustit, Virginie Marquette, Béatrice Bocquet, Josseline Kaplan, Isabelle Perrault, Isabelle Meunier, Christian P Hamel
PURPOSE: To describe a patient with mutations in KCNJ13 presenting particular clinical features. METHODS: Standard ophthalmic examination, fundus autofluorescence, spectral domain optical coherence tomography, full-field electroretinography. The 3 exons of KCNJ13 were polymerase chain reaction amplified and Sanger sequenced. PATIENTS: A 31-year-old man with Leber congenital amaurosis. RESULTS: Patient had nystagmus since childhood, best-corrected visual acuity limited to 20/400 OD and 20/200 OS, and had cataracts extracted in both eyes...
May 19, 2016: Retinal Cases & Brief Reports
Ho Sik Hwang, Jee Hye Lee, Soo Ji Jeon, Bo Young Lee, Yang Kyung Cho
PURPOSE: To compare the outcomes of two nuclear fracture techniques used in phacoemulsification (stop-chop vs. retro-chop). METHODS: A total of 131 eyes from 111 patients with severe cataracts and nucleosclerosis (of grades 4-5) were included. The patients were randomly assigned to undergo stop-chop or retro-chop nucleotomy during phacoemulsification. The Drysdale manipulator was used as the chopping instrument in both groups. The intraocular phacoemulsification parameters including phacoemulsification power and phacoemulsification time were compared across the two groups...
May 9, 2016: Current Eye Research
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