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enteropathic arthritis

Maurizio Benucci, Francesca Li Gobbi, Francesca Bandinelli, Arianna Damiani, Maria Infantino, Valentina Grossi, Mariangela Manfredi, Simone Parisi, Enrico Fusaro, Alberto Batticciotto, Piercarlo Sarzi-Puttini, Fabiola Atzeni, Francesca Meacci
Biosimilar infliximab (INX) was recently approved by the European Medicine Agency for the treatment of rheumatoid arthritis, ankylosing spondylitis (AS), Crohn's disease, ulcerative colitis, psoriatic arthritis (PsA), and psoriasis on the grounds that its pharmacokinetics, safety, and efficacy were comparable to those of innovator INX. The aim of this study was to investigate the real-life efficacy, safety, and immunogenicity of switching from innovator to biosimilar INX in patients with spondyloarthritis (SpA)...
July 23, 2016: Immunologic Research
Yuki Nanke, Tsuyoshi Kobashigawa, Hisashi Yamanaka, Shigeru Kotake
  We report a 36-year-old male patient who suffered from polyarthritis after the remission of ulcerative colitis. He was diagnosed with enteropathic arthritis type 2, against which methotrexate was effective.
2016: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
Takanori Asakura, Makoto Ishii, Taku Kikuchi, Kaori Kameyama, Ho Namkoong, Noboru Nakata, Kayoko Sugita, Sadatomo Tasaka, Takayuki Shimizu, Yoshihiko Hoshino, Shinichiro Okamoto, Tomoko Betsuyaku, Naoki Hasegawa
Mycobacterium marinum is a ubiquitous waterborne organism that mainly causes skin infection in immunocompetent patients, and its disseminated infection is rare. Extranodal NK/T cell lymphoma, nasal type (ENKL) usually localizes at the nasal and/or paranasal area, but occasionally disseminates into the skin/soft tissue and gastrointestinal tract. Compromised immunity is a risk factor for developing nontuberculous mycobacterial (NTM) infection and malignant lymphoma, and the 2 diseases may share similar clinical presentation; however, only a few reports have described NTM infection mimicking malignant lymphoma...
March 2016: Medicine (Baltimore)
Mark J Soloski, Eleanor S Metcalf
A clear etiological link has been established between infection with several gram-negative enteric pathogens, including Salmonella spp., and the incidence of reactive arthritis (ReA), an autoimmune disease that largely affects the joints. ReA is sometimes referred to as Reiter's syndrome, particularly when accompanied by uveitis and urethritis. This review reviews the evidence etiologically linking Salmonella infection with autoimmune disease and addresses the roles that bacterial and host elements play in controlling disease outcome...
April 2007: EcoSal Plus
Matthew A Brown, Tony Kenna, B Paul Wordsworth
Ankylosing spondylitis (AS), an immune-mediated arthritis, is the prototypic member of a group of conditions known as spondyloarthropathies that also includes reactive arthritis, psoriatic arthritis and enteropathic arthritis. Patients with these conditions share a clinical predisposition for spinal and pelvic joint dysfunction, as well as genetic associations, notably with HLA-B(*)27. Spondyloarthropathies are characterized by histopathological inflammation in entheses (regions of high mechanical stress where tendons and ligaments insert into bone) and in the subchondral bone marrow, and by abnormal osteoproliferation at involved sites...
February 2016: Nature Reviews. Rheumatology
Elena Generali, Angela Ceribelli, Marco Massarotti, Luca Cantarini, Carlo Selmi
Spondyloarthritidies represent a group of conditions affecting the axial and peripheral muscoloskeletal apparatus and are often associated with psoriasis, infections, and inflammatory bowel diseases. Other diseases included in this category are psoriatic arthritis, ankylosing spondylitis, and enteropathic arthritis. Reactive arthritis is an elusive spondyloarthritis, commonly occurring 1 to 3 weeks after a digestive or a genitourinary tract infection, in which microorganisms do not infect the joint directly...
September 2015: Clinics in Dermatology
Periklis Vounotrypidis, Periklis Pappas, Vasilios Vrangalas, Anthimos Pehlivanidis
Chronic wounds develop when the sequence of healing events are disrupted, usually in patients with underlying diseases such as diabetes mellitus, venous insufficiency, peripheral artery disease, and neuropathies and they affect most often the lower extremities. We present a 68-year-old woman with plantar ulceration, lasting for approximately 18 months, resistant to healing with conventional therapy and various modalities we used. The patient had a long history of seronegative enteropathic arthritis, Crohn's disease, secondary fibrillar amyloidosis, multiplex neuropathy, and small vessel vasculitis, the latter being the trigger event for the ulceration of her right foot...
September 2015: International Journal of Lower Extremity Wounds
Rosario García-Vicuña, Pedro Zarco, Carlos M González, Francisco Vanaclocha, Ignacio Marín-Jiménez, Luis Cea-Calvo
OBJECTIVES: To describe the 2-year incidence of new extra-articular manifestations (uveitis, psoriasis, inflammatory bowel disease) in a cohort of patients with spondyloarthritis included in the AQUILES study. PATIENTS: Over a period of 2 years, 513 patients with spondyloarthritis (62.5% males, mean age 48 years) diagnosed with ankylosing spondylitis (AS) (55.6%), psoriatic arthritis (25.3%), undifferentiated spondyloarthritis (16.2%), enteropathic arthritis (2...
January 2016: Reumatología Clinica
Julia Manasson, Jose U Scher
The human microbiome, which represents the total collection of microorganisms (and their genes) inhabiting the human body, has increasingly been recognized as a potential key factor in the development of autoimmune disease. Multiple studies suggest that the microbiome has significant influence on immune homeostasis, while disruptions in local microbiome composition can result in a heightened systemic inflammatory response. The intestinal microbiome, in particular, harbors the densest assembly of bacteria and appears to influence the immune system in the context of inflammatory arthropathies...
February 2015: Current Rheumatology Reports
Pedro Zarco, Carlos M González, Arturo Rodríguez de la Serna, Enriqueta Peiró, Isabel Mateo, Luis Linares, Jerusalem Calvo, Luis Cea-Calvo, María J Arteaga, Francisco Vanaclocha, Ignacio Marín-Jiménez, Rosario García-Vicuña
OBJECTIVES: To describe the prevalence of extra-articular disease (uveitis, psoriasis and inflammatory bowel disease [IBD]), in a cohort of patients with spondyloarthritis (SpA). PATIENTS AND METHODS: AQUILES is an observational, prospective and multicentric study of three cohorts of patients with one of the following immune-mediated inflammatory diseases (IMID): SpA, psoriasis, or IBD. In the present cohort, patients ≥18 years of age with SpA were enrolled from Rheumatology clinics...
March 2015: Reumatología Clinica
Amir Kashani, Morteza Chitsazan, Kendrick Che, Roger C Garrison
Patients with inflammatory bowel disease (IBD) are a high risk population for bacteremia. Derangement in the mucosal architecture of the gastrointestinal (GI) tract and frequent endoscopic interventions in immunocompromised individuals are considered primary causes. Isolation of opportunistic microorganisms from the bloodstream of IBD patients has been increasingly reported in recent years. Leclercia adecarboxylata is a ubiquitous, aerobic, motile, gram-negative bacillus. The human GI tract is known to harbor this rarely pathogenic microorganism...
2014: Case Reports in Gastrointestinal Medicine
Reza Eslami, Mahmud Momenzadeh, Ahmad Ebadi
Rheumatologic diseases are a challenging diagnosis when it comes to air medical disposition decision making because many of these diseases overlap and their initial presentation is insidious and relapsing remitting in future scope. Many rheumatologic diseases have musculoskeletal and other organ complications. One of these diagnoses is spondyloarthritides. These disorders include ankylosing spondylitis (AS), reactive arthritis, psoriatic arthritis and spondylitis, enteropathic arthritis and spondylitis, juvenile-onset spondyloarthritis, and undifferentiated spondyloarthritis...
May 2014: Air Medical Journal
Gustavo G Resende, Cristina C D Lanna, Adriana B Bortoluzzo, Célio R Gonçalves, José Antonio Braga da Silva, Antonio Carlos Ximenes, Manoel B Bértolo, Sandra L E Ribeiro, Mauro Keiserman, Rita Menin, Thelma L Skare, Sueli Carneiro, Valderílio F Azevedo, Walber P Vieira, Elisa N Albuquerque, Washington A Bianchi, Rubens Bonfiglioli, Cristiano Campanholo, Hellen M S Carvalho, Izaias P Costa, Angela P Duarte, Charles L Kohem, Nocy Leite, Sonia A L Lima, Eduardo S Meirelles, Ivânio A Pereira, Marcelo M Pinheiro, Elizandra Polito, Francisco Airton C Rocha, Mittermayer B Santiago, Maria de Fátima L C Sauma, Valeria Valim, Percival D Sampaio-Barros
UNLABELLED: Inflammatory bowel diseases (Crohn's disease and ulcerative rectocolitis) have extraintestinal manifestations 25% of the patients, with the most common one being the enteropathic arthritis. METHODS: Prospective, observational, multicenter study with patients from 29 reference centers participating in the Brazilian Registry of Spondyloarthritis (RBE), which incorporates the RESPONDIA (Ibero-American Registry of Spondyloarthritis) group. Demographic and clinical data were collected from 1472 patients and standardized questionnaires for the assessment of axial mobility, quality of life, enthesitic involvement, disease activity and functional capacity were applied...
November 2013: Revista Brasileira de Reumatologia
Tamer A Gheita, Iman I El Gazzar, Hussein S El-Fishawy, Mohamed A Aboul-Ezz, Sanaa A Kenawy
The role of interleukin (IL)-23 in the pathogenesis of inflammatory bowel disease (IBD) remains unclear. The aim of this work was to study the serum level of IL-23 in IBD with and without arthritis and determine its relation to the subsets and clinical features of the disease. Thirty-seven patients with IBD including 11 with arthritis were included in the study with a mean age of 30.86 ± 4.66 years. Twenty healthy subjects served as control. Seronegative spondyloarthropathy was present in 11 (29.73 %) of the IBD patients; Crohn's disease (CD) was present in 23 and 14 had ulcerative colitis (UC)...
May 2014: Clinical Rheumatology
Francesco Paparo, Matteo Revelli, Alessia Semprini, Dario Camellino, Alessandro Garlaschi, Marco Amedeo Cimmino, Gian Andrea Rollandi, Antonio Leone
Inflammatory involvement of the spine and sacroiliac joints is the most peculiar feature of seronegative spondyloarthropathies (SpA), which include ankylosing spondylitis, psoriatic arthritis, reactive arthritis (Reiter's syndrome), enteropathic spondylitis (related to inflammatory bowel diseases) and undifferentiated spondyloarthropathies. SAPHO syndrome may also be considered a SpA, but there is no clear agreement in this respect. Imaging, along with clinical and laboratory evaluation, is an important tool to reach a correct diagnosis and to provide a precise grading of disease progression, influencing both clinical management and therapy...
March 2014: La Radiologia Medica
Mauro Scarpelli, Giuseppe Kenneth Ricciardi, Alberto Beltramello, Isabella Zocca, Francesca Calabria, Anna Russignan, Francesca Zappini, Maria Sofia Cotelli, Alessandro Padovani, Giuliano Tomelleri, Massimiliano Filosto, Paola Tonin
Leukoencephalopathy is a hallmark of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) a devastating disorder characterized by ptosis, ophthalmoparesis, gastrointestinal dysfunction and polyneuropathy. To characterize MNGIE-associated leukoencephalopathy and to correlate it with clinical, biochemical and molecular data, four MNGIE patients with heterogeneous clinical phenotypes (enteropathic arthritis, exercise intolerance, CIDP-like phenotype and typical presentation) were studied by magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS)...
October 2013: Neuroradiology Journal
Sueli Carneiro, Adriana Bortoluzzo, Celio Gonçalves, José Antonio Braga da Silva, Antonio C Ximenes, Manoel Bértolo, Sandra Lúcia Ribeiro, Mauro Keiserman, Thelma Skare, Rita Menin, Valderilio Azevedo, Walber Vieira, Elisa Albuquerque, Washington Bianchi, Rubens Bonfiglioli, Cristiano Campanholo, Hellen Mary de Carvalho, Izaias da Costa, Angela Duarte, Charles Kohem, Nocy Leite, Sonia A L Lima, Eduardo S Meirelles, Ivânio A Pereira, Marcelo M Pinheiro, Elizandra Polito, Gustavo G Resende, Francisco Airton C Rocha, Mittermayer B Santiago, Maria de Fátima L C Sauma, Valéria Valim, Percival D Sampaio-Barros
OBJECTIVE: To analyze the clinical effect of enthesitis in a large Brazilian cohort of patients with spondyloarthritis (SpA). METHODS: A common protocol of investigation was prospectively applied to 1505 patients with SpA in 29 centers in Brazil. Clinical and demographic variables and disease indexes were investigated. The Maastricht Ankylosing Spondylitis Enthesitis Score was used to investigate the enthesitis component. Ankylosing spondylitis was the most frequent disease in the group (65...
October 2013: Journal of Rheumatology
Rosario Peluso, Matteo Nicola Dario Di Minno, Salvatore Iervolino, Francesco Manguso, Giuseppina Tramontano, Pasquale Ambrosino, Carmela Esposito, Antonella Scalera, Fabiana Castiglione, Raffaele Scarpa
Enteropathic arthritis (EA) is a spondyloarthritis (SpA) which occurs in patients with inflammatory bowel diseases (IBDs) and other gastrointestinal diseases. Diagnosis is generally established on the medical history and physical examination. It was, generally, made according to the European Spondyloarthropathy Study Group (ESSG) criteria. Rheumatic manifestations are the most frequent extraintestinal findings of IBD with a prevalence between 17% and 39%, and IBD is associated, less frequently, with other rheumatic disease such as rheumatoid arthritis, Sjogren syndrome, Takayasu arteritis, and fibromyalgia...
2013: Clinical & Developmental Immunology
Rosario Peluso, Matteo Nicola Dario DI Minno, Vincenzo Bruner, Ernesto Soscia, Fabiana Castiglione, Francesco Manguso, Salvatore Iervolino, Raffaele Scarpa
OBJECTIVE: Magnetic resonance imaging (MRI) is considered the modality of choice for the diagnosis of spondyloarthropathy (SpA)-related spondylodiscitis, or discovertebral erosions (DE). Our aim was to analyze the prevalence and the clinical features of DE in patients with enteropathic SpA (EA) using MRI. METHODS: We evaluated 72 patients with EA and 43 controls for the study. All patients and controls underwent rheumatological and gastroenterological clinical examinations, and demographic features were recorded...
December 2012: Journal of Rheumatology
T L Skare, N Leite, A B Bortoluzzo, C R Gonçalves, J A B da Silva, A C Ximenes, M B Bértolo, S L E Ribeiro, M Keiserman, R Menin, S Carneiro, V F Azevedo, W P Vieira, E das N Albuquerque, W A Bianchi, R Bonfiglioli, C Campanholo, H M S Carvalho, I P Costa, A P Duarte, M B O Gavi, C L Kohem, S A L Lima, E S Meirelles, I A Pereira, M M Pinheiro, E Polito, G G Resende, F A C Rocha, M B Santiago, M de F L C Sauma, P D Sampaio-Barros
OBJECTIVES: To analyse demographic and clinical variables in patients with disease onset before and after 40, 45 and 50 years in a large series of Brazilian SpA patients. METHODS: A common protocol of investigation was prospectively applied to 1424 SpA patients in 29 centres distributed through the main geographical regions in Brazil. The mean age at disease onset was 28.56 ± 12.34 years, with 259 patients (18.2%) referring disease onset after 40 years, 151 (10...
May 2012: Clinical and Experimental Rheumatology
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