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post interferon syndrome

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https://www.readbyqxmd.com/read/29882085/transcriptional-profiles-of-pbmcs-from-pigs-infected-with-three-genetically-diverse-porcine-reproductive-and-respiratory-syndrome-virus-strains
#1
Marzena Rola-Łuszczak, Magdalena Materniak-Kornas, Aneta Pluta, Katarzyna Podgórska, Jens Nielsen, Tomasz Stadejek, Jacek Kuźmak
Porcine reproductive and respiratory syndrome virus is the cause of reproductive failure in sows and respiratory disease in young pigs, which has been considered as one of the most costly diseases to the worldwide pig industry for almost 30 years. This study used microarray-based transcriptomic analysis of PBMCs from experimentally infected pigs to explore the patterns of immune dysregulation after infection with two East European PRRSV strains from subtype 2 (BOR and ILI) in comparison to a Danish subtype 1 strain (DAN)...
June 7, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/29880387/azithromycin-fails-to-prevent-accelerated-airway-obliteration-in-t-bet-mouse-lung-allograft-recipients
#2
E A Lendermon, J M Dodd-O, T A Coon, X Wang, C R Ensor, N Cardenes, C L Koodray, H L Heusey, M F Bennewitz, P Sundd, G C Bullock, I Popescu, L Guo, C P O'Donnell, M Rojas, J F McDyer
BACKGROUND: Cellular and molecular mechanisms of acute and chronic lung allograft rejection have yet to be clearly defined, and obliterative bronchiolitis (OB) remains the primary limitation to survival in lung transplant recipients (LTRs). We have previously shown that T-bet-deficient recipients of full major histocompatibility complex (MHC)-mismatched, orthotopic left lung transplants develop accelerated obliterative airway disease (OAD) in the setting of acute cellular rejection characterized by robust alloimmune CD8+ interleukin (IL)-17 and interferon (IFN)-γ responses that are attenuated with neutralization of IL-17...
June 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29754448/periodontal-infection-with-porphyromonas-gingivalis-induces-preterm-birth-and-lower-birth-weight-in-rats
#3
Shanshan Liang, Hongyu Ren, Haiying Guo, Wenyan Xing, Chang Liu, Yaoting Ji, Han Jiang, Ping Zhang, Minquan Du
Preterm birth (PTB), accompanied by low birth weight (LBW) or not, is a syndrome with tremendous risk factors and long-term health consequences for children. In recent decades, overwhelming studies have shown that periodontitis contributes to prematurity and LBW. This study was conducted to determine the link between maternal periodontitis and the pathogenesis of PTB and/or LBW through a rat infection model induced by Porphyromonas gingivalis, an important periodontopathic bacterium. The murine model was established by surgically ligating the left mandibular 1st molars and inoculating with P...
May 13, 2018: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/29651287/neutralizing-anti-cytokine-autoantibodies-against-interferon-%C3%AE-in-immunodysregulation-polyendocrinopathy-enteropathy-x-linked
#4
Jacob M Rosenberg, Maria E Maccari, Federica Barzaghi, Eric J Allenspach, Claudio Pignata, Giovanna Weber, Troy R Torgerson, Paul J Utz, Rosa Bacchetta
Anti-cytokine autoantibodies (ACAAs) have been described in a growing number of primary immunodeficiencies with autoimmune features, including autoimmune polyendocrine syndrome type I (APS-1), a prototypical disease of defective T cell-mediated central tolerance. Whether defects in peripheral tolerance lead to similar ACAAs is unknown. Immunodysregulation polyendocrinopathy enteropathy X-linked (IPEX) is caused by mutations in FOXP3 , a master regulator of T regulatory cells (Treg ), and consequently results in defective T cell-mediated peripheral tolerance...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29619588/autoimmune-inflammatory-syndrome-induced-by-mineral-oil-a-health-problem
#5
Olga Vera-Lastra, Gabriela Medina, María Pilar Cruz-Domínguez, Gabriel Medrano Ramírez, Raymundo Benjamin Priego Blancas, Ana Lilia Peralta Amaro, Anabel Villanueva Martínez, Jesús Sepúlveda Delgado, Luis J Jara
Autoimmune/inflammatory syndrome induced by adjuvant (ASIA) includes the following conditions: siliconosis, Gulf War syndrome, macrophagic myofasciitis syndrome, and post-vaccination phenomena. Afterward, other syndromes have been recognized, such as in ASIA by mineral oil (ASIA-MO). These conditions are triggered by adjuvants and they are the result of the interplay of genetic and environmental factors. ASIA-MO is defined as the infiltration of oily type modeling substances for cosmetic purposes. It has been reported in many countries and used surreptitiously...
June 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29581859/a-pilot-study-on-primary-cultures-of-human-respiratory-tract-epithelial-cells-to-predict-patients-responses-to-h7n9-infection
#6
Chung-Guei Huang, Li-Ang Lee, Yi-Cheng Wu, Mei-Jen Hsiao, Jim-Tong Horng, Rei-Lin Kuo, Chih-Heng Huang, Ya-Chu Lin, Kuo-Chien Tsao, Min-Chi Chen, Tse-Ching Chen, Shin-Ru Shih
Avian influenza A(H7N9) virus infections frequently lead to acute respiratory distress syndrome and death in humans. We aimed to investigate whether primary cultures of human respiratory tract epithelial cells are helpful to understand H7N9 virus pathogenesis and tissue tropism, and to evaluate how patient-related characteristics can affect the host's response to infection. Normal human bronchial epithelial cells (isolated from two different donors) and primary epithelial cells (harvested from 27 patients undergoing airway surgery) were experimentally infected with H7N9 and/or H1N1pdm for 72 h...
March 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29475453/whole-transcriptome-analysis-reveals-differential-gene-expression-profile-reflecting-macrophage-polarization-in-response-to-influenza-a-h5n1-virus-infection
#7
Na Zhang, Yun-Juan Bao, Amy Hin-Yan Tong, Scott Zuyderduyn, Gary D Bader, J S Malik Peiris, Si Lok, Suki Man-Yan Lee
BACKGROUND: Avian influenza A H5N1 virus can cause lethal disease in humans. The virus can trigger severe pneumonia and lead to acute respiratory distress syndrome. Data from clinical, in vitro and in vivo suggest that virus-induced cytokine dysregulation could be a contributory factor to the pathogenesis of human H5N1 disease. However, the precise mechanism of H5N1 infection eliciting the unique host response are still not well understood. METHODS: To obtain a better understanding of the molecular events at the earliest time points, we used RNA-Seq to quantify and compare the host mRNA and miRNA transcriptomes induced by the highly pathogenic influenza A H5N1 (A/Vietnam/3212/04) or low virulent H1N1 (A/Hong Kong/54/98) viruses in human monocyte-derived macrophages at 1-, 3-, and 6-h post infection...
February 23, 2018: BMC Medical Genomics
https://www.readbyqxmd.com/read/29426834/value-of-circulating-cytokine-profiling-during-submaximal-exercise-testing-in-myalgic-encephalomyelitis-chronic-fatigue-syndrome
#8
Kegan J Moneghetti, Mehdi Skhiri, Kévin Contrepois, Yukari Kobayashi, Holden Maecker, Mark Davis, Michael Snyder, Francois Haddad, Jose G Montoya
Myalgic Encephalomyelitis or Chronic Fatigue Syndrome (ME/CFS) is a heterogeneous syndrome in which patients often experience severe fatigue and malaise following exertion. Immune and cardiovascular dysfunction have been postulated to play a role in the pathophysiology. We therefore, examined whether cytokine profiling or cardiovascular testing following exercise would differentiate patients with ME/CFS. Twenty-four ME/CFS patients were matched to 24 sedentary controls and underwent cardiovascular and circulating immune profiling...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29387185/porcine-reproductive-and-respiratory-syndrome-virus-suppresses-post-transcriptionally-the-protein-expression-of-ifn-%C3%AE-by-upregulating-cellular-micrornas-in-porcine-alveolar-macrophages-in-vitro
#9
Lilin Wang, Lei Zhou, Dongmei Hu, Xinna Ge, Xin Guo, Hanchun Yang
Porcine reproductive and respiratory syndrome virus (PRRSV) has been recognized to inhibit the response of type I interferon (IFN) both in vivo and in vitro . However, the post-transcriptional mechanism by which PRRSV suppresses type I IFN induction in virus-infected host cells remains unclear. The present study first demonstrated that PRRSV inhibited post-transcriptionally the protein induction of IFN-β in primary porcine alveolar macrophages (PAMs) during early infection, and the inhibition effect mediated by the Chinese highly pathogenic (HP)-PRRSV was stronger...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29382967/comparison-of-3-vaccination-strategies-against-porcine-reproductive-and-respiratory-syndrome-virus-mycoplasma-hyopneumoniae-and-porcine-circovirus-type-2-on-a-3-pathogen-challenge-model
#10
Jiwoon Jeong, Ikjae Kang, Seeun Kim, Kee Hwan Park, Changhoon Park, Chanhee Chae
The objective of this study was to compare clinical, microbiologic, immunologic, and pathologic parameters in pigs each concurrently administered porcine reproductive and respiratory syndrome virus (PRRSV), Mycoplasma hyopneumoniae, and porcine circovirus type 2 (PCV2) vaccine from 1 of 2 commercial sources at 21 days of age and challenged with field strains of each of the 3 pathogens. Pigs were challenged with PRRSV and M. hyopneumoniae at 42 days of age (-14 days post-challenge, dpc) followed by a challenge with PCV2 at 56 days of age (0 dpc)...
January 2018: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/29365277/interferon-%C3%AE-improves-sepsis-related-alveolar-macrophage-dysfunction-and-post-septic-ards-related-mortality
#11
Takahiro Hiruma, Hitoshi Tsuyuzaki, Kanji Uchida, Bruce C Trapnell, Yoshiro Yamamura, Yoshiomi Kusakabe, Tokie Totsu, Takuji Suzuki, Shigeki Morita, Kent Doi, Eisei Noiri, Kensuke Nakamura, Susumu Nakajima, Naoki Yahagi, Naoto Morimura, Kyungho Chang, Yoshitsugu Yamada
Interferon-β (IFNβ) is reported to improve survival in patients with acute respiratory distress syndrome (ARDS), possibly by preventing sepsis-induced immunosuppression, but its therapeutic nature in ARDS pathogenesis is poorly understood. We investigated the therapeutic effects of IFNβ for post-septic ARDS to better understand its pathogenesis in mice. Post-septic ARDS was reproduced in mice by cecal ligation and puncture to induce sepsis followed 4 days later by intratracheal instillation of Pseudomonas aeruginosa to cause pneumonia with or without subcutaneous administration of IFNβ 1 day earlier...
January 24, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29281106/delayed-interferon-type-1-induced-antiviral-state-is-a-potential-factor-for-hemorrhagic-fever-with-renal-syndrome-severity
#12
Katarina Resman Rus, Miša Korva, Petra Bogovic, Emil Pal, Franc Strle, Tatjana Avšic-Županc
Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) in Europe and Asia. Interferon (IFN) responses play an important role in HFRS pathogenesis and early IFN-β response is delayed by pathogenic hantaviruses. The severity of HFRS caused by Dobrava virus (DOBV) and Puumala virus (PUUV) varies. Our aim was to determine whether differences in early activation of IFN type 1-induced antiviral state influence HFRS severity. Peripheral blood mononuclear cells (PBMCs) from healthy donors and HFRS patients were stimulated with DOBV or PUUV and expression of selected genes was measured...
March 5, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29162707/cd4-t-cells-orchestrate-lethal-immune-pathology-despite-fungal-clearance-during-cryptococcus-neoformans-meningoencephalitis
#13
Lori M Neal, Enze Xing, Jintao Xu, Jessica L Kolbe, John J Osterholzer, Benjamin M Segal, Peter R Williamson, Michal A Olszewski
Cryptococcus neoformans is a major fungal pathogen that disseminates to the central nervous system (CNS) to cause fatal meningoencephalitis, but little is known about immune responses within this immune-privileged site. CD4+ T cells have demonstrated roles in anticryptococcal defenses, but increasing evidence suggests that they may contribute to clinical deterioration and pathology in both HIV-positive (HIV+) and non-HIV patients who develop immune reconstitution inflammatory syndrome (IRIS) and post-infectious inflammatory response syndrome (PIIRS), respectively...
November 21, 2017: MBio
https://www.readbyqxmd.com/read/29106401/irf3-and-type-i-interferons-fuel-a-fatal-response-to-myocardial-infarction
#14
Kevin R King, Aaron D Aguirre, Yu-Xiang Ye, Yuan Sun, Jason D Roh, Richard P Ng, Rainer H Kohler, Sean P Arlauckas, Yoshiko Iwamoto, Andrej Savol, Ruslan I Sadreyev, Mark Kelly, Timothy P Fitzgibbons, Katherine A Fitzgerald, Timothy Mitchison, Peter Libby, Matthias Nahrendorf, Ralph Weissleder
Interferon regulatory factor 3 (IRF3) and type I interferons (IFNs) protect against infections and cancer, but excessive IRF3 activation and type I IFN production cause autoinflammatory conditions such as Aicardi-Goutières syndrome and STING-associated vasculopathy of infancy (SAVI). Myocardial infarction (MI) elicits inflammation, but the dominant molecular drivers of MI-associated inflammation remain unclear. Here we show that ischemic cell death and uptake of cell debris by macrophages in the heart fuel a fatal response to MI by activating IRF3 and type I IFN production...
December 2017: Nature Medicine
https://www.readbyqxmd.com/read/29103685/cholesterol-25-hydroxylase-is-an-interferon-inducible-factor-that-protects-against-porcine-reproductive-and-respiratory-syndrome-virus-infection
#15
Zhongbao Song, Qiaoya Zhang, Xuewei Liu, Juan Bai, Yongxiang Zhao, Xianwei Wang, Ping Jiang
Porcine reproductive and respiratory syndrome virus (PRRSV), a single-stranded, positive-sense RNA virus of the Arteriviridae family, has become a global health threat for swine. Cholesterol 25-hydroxylase (CH25H) is an enzyme that catalyzes oxidation of cholesterol to 25-hydroxycholesterol (25HC). The purpose of this study was to explore the antiviral activity of CH25H against PRRSV infection. We found that CH25H was induced by interferon-α and PRRSV in Marc-145 monkey kidney cells. In addition, CH25H and 25HC significantly inhibited PRRSV infection by preventing virus entry...
October 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29070690/genotype-2-strains-of-porcine-reproductive-and-respiratory-syndrome-virus-dysregulate-alveolar-macrophage-cytokine-production-via-the-unfolded-protein-response
#16
Wei-Yu Chen, William M Schniztlein, Gabriela Calzada-Nova, Federico A Zuckermann
Porcine reproductive and respiratory syndrome virus (PRRSV) infects alveolar macrophages (AMΦ) causing dysregulated interferon (IFN)-α and tumor necrosis factor (TNF)-α production through a mechanism(s) yet to be resolved. Here, we show that AMΦ infected with PRRSV secreted a reduced quantity of IFN-α following the cell exposure to synthetic dsRNA. This reduction did not correlate with reduced IFNA1 gene transcription. Rather, it coincided with two events that occurred late during infection and were indicative of translational attenuation, specifically, the activation of eukaryotic translation initiation factor 2α (eIF2α), and the appearance of stress granules...
October 25, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28912779/v%C3%AE-4-%C3%AE-%C3%AE-t-cells-aggravate-severe-h1n1-influenza-virus-infection-induced-acute-pulmonary-immunopathological-injury-via-secreting-interleukin-17a
#17
Chunxue Xue, Mingjie Wen, Linlin Bao, Hui Li, Fengdi Li, Meng Liu, Qi Lv, Yunqing An, Xulong Zhang, Bin Cao
The influenza A (H1N1) pdm09 virus remains a critical global health concern and causes high levels of morbidity and mortality. Severe acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the major outcomes among severely infected patients. Our previous study found that interleukin (IL)-17A production by humans or mice infected with influenza A (H1N1) pdm09 substantially contributes to ALI and subsequent morbidity and mortality. However, the cell types responsible for IL-17A production during the early stage of severe influenza A (H1N1) pdm09 infection remained unknown...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28836962/microrna-expression-profiling-of-porcine-mammary-epithelial-cells-after-challenge-with-escherichia-coli-in-vitro
#18
A Jaeger, F Hadlich, N Kemper, A Lübke-Becker, E Muráni, K Wimmers, S Ponsuksili
BACKGROUND: Coliform mastitis is a symptom of postpartum dysgalactia syndrome (PDS), a multifactorial infectious disease of sows. Our previous study showed gene expression profile change after bacterial challenge of porcine mammary epithelial cells (PMECs). These mRNA expression changes may be regulated through microRNAs (miRNAs) which play critical roles in biological processes. Therefore, miRNA expression profile was investigated in PMECs. RESULTS: PMECs were isolated from three lactating sows and challenged with heat-inactivated potential mastitis-causing pathogen Escherichia coli (E...
August 24, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28802661/efficacy-of-isolated-limb-perfusion-ilp-in-patients-with-merkel-cell-carcinoma-mcc-a-multicenter-experience
#19
MULTICENTER STUDY
L M van Veenendaal, M F Madu, M E T Tesselaar, C Verhoef, D J Grünhagen, A C J van Akkooi
BACKGROUND: Merkel cell carcinoma (MCC) is a rare and potentially aggressive neuroendocrine tumor of the skin, with a propensity for locoregional metastases. In two expert referral centers, isolated limb perfusion (ILP) is used to obtain locoregional control in selected locoregionally advanced MCC patients. This study describes our experience. METHOD: Patients who underwent ILP for MCC were analyzed. ILP was performed with melphalan and tumor necrosis factor (TNF) combination therapy...
November 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28766554/campylobacter-jejuni-impairs-sodium-transport-and-epithelial-barrier-function-via-cytokine-release-in-human-colon
#20
R Bücker, S M Krug, V Moos, C Bojarski, M R Schweiger, M Kerick, A Fromm, S Janßen, M Fromm, N A Hering, B Siegmund, T Schneider, C Barmeyer, J D Schulzke
Campylobacter jejuni is the most prevalent cause of foodborne bacterial enteritis worldwide. Patients present with diarrhea and immune responses lead to complications like arthritis and irritable bowel syndrome. Although studies exist in animal and cell models, we aimed at a functional and structural characterization of intestinal dysfunction and the involved regulatory mechanisms in human colon. First, in patients' colonic biopsies, sodium malabsorption was identified as an important diarrheal mechanism resulting from hampered epithelial ion transport via impaired epithelial sodium channel (ENaC) β- and γ-subunit...
March 2018: Mucosal Immunology
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